8,361 results match your criteria Biomacromolecules[Journal]


Thermogelling Inclusion Complex System for Fine-Tuned Osteochondral Differentiation of Mesenchymal Stem Cells.

Biomacromolecules 2020 Jul 8. Epub 2020 Jul 8.

How to control osteochondral differentiation of mesenchymal stem cells at a proper stage is a key issue for articular cartilage regeneration. To solve this problem, injectable scaffolds with different chemical functional groups were designed by introducing one equivalent of α-cyclodextrin (α-CD) carboxylate and α-CD phosphate along poly(ethylene glycol)-poly(L-alanine) (PEG-L-PA) block copolymers. Dynamic light scattering, transmission electron microscopy images, and two dimensional NMR spectra indicated that the PEG-L-PA block copolymers formed inclusion complexes with α-CD derivatives. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00623DOI Listing

Poly(2-ethyl-2-oxazoline) Conjugates with Salicylic Acid via Degradable Modular Ester Linkages.

Biomacromolecules 2020 Jul 8. Epub 2020 Jul 8.

Conjugation of drugs to polymers is a widely used approach to gain control over the release of therapeutics. In this contribution, salicylic acid, a multipurpose model drug, is conjugated to the biocompatible poly(2-ethyl-2-oxazoline) (PEtOx). The drug is attached to the side chains of a polymer carrier trough a hydrolytically cleavable ester linker, via a sequential post-polymerization modification. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00659DOI Listing

Polyhydroxybutyrate bioresins with high thermal stability by crosslinking with resorcinol diglycidyl ether.

Biomacromolecules 2020 Jul 7. Epub 2020 Jul 7.

The development of sustainable materials employing natural and non-toxic resources has been attracting much attention in the last years. In this work, we discuss in premiere the chemical combination between resorcinol diglycidyl ether (RDGE), an aromatic biobased thermosetting monomer, and polyhydroxybutyrate (PHB), a bio-derived and biodegradable thermoplastic polyester. By this combination we searched to associate the high thermal stability of RDGE with a toughening effect by aliphatic chains of PHB. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00876DOI Listing

Lignin-Bimetallic Nanoconjugate Doped pH-Responsive Hydrogels for Laser-Assisted Antimicrobial Photodynamic Therapy.

Biomacromolecules 2020 Jul 6. Epub 2020 Jul 6.

Bioinspired nano-antimicrobials stand out in terms of cost effectiveness and scalability when compared to their chemically synthesized counterparts. There is limited efficacy of current antibiotics due to their interference with the immune system as well as development of antibiotic resistance. Lignin which is a naturally abundant polyphenol-rich biopolymer, can be utilized for the fabrication of sustainable antimicrobial materials. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00695DOI Listing

Monodisperse and polydisperse PEGylation of peptides and proteins: a comparative study.

Biomacromolecules 2020 Jul 6. Epub 2020 Jul 6.

Although PEGylation is widely used in biomedicine with great success, it suffers many drawbacks, such as polydispersity, non-biodegradability, and loss of precursor potency. Recently, the search for polyethylene glycols (PEGs) substitutes has attracted considerable attention. Some of the substitutes partially address the drawbacks of PEGs, but sacrifice the "stealth" effect of PEGs and bring in new issues. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00517DOI Listing

Theoretical rationalization of self-assembly of cellulose nanocrystals: effect of surface modifications and counterions.

Biomacromolecules 2020 Jul 3. Epub 2020 Jul 3.

The hierarchical self-assembly of cellulose nanocrystals (CNCs) is an important phenomenon occurring naturally in plant cell walls. Utilization of this assembly for advanced applications requires a fundamental theoretical understanding of interactions between the CNCs, which is still incomplete. Hence, in this work we used molecular dynamics simulations to study the effect of surface modification on the interactions between the CNCs and the resulting bundling process. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00469DOI Listing

Study of interactions between antigens and polymeric adjuvants in vaccines by frontal analysis continuous capillary electrophoresis.

Biomacromolecules 2020 Jul 1. Epub 2020 Jul 1.

Vaccine adjuvants are used to enhance the immune response induced by antigens that have insufficient immunostimulatory capabilities. The present work aims at developing frontal analysis continuous capillary electrophoresis (FACCE) methodology for the study of antigen-adjuvant interactions in vaccine products. After method optimization using three cationic model proteins, namely lysozyme, cytochrome C and ribonuclease A, FACCE was successfully implemented to quantify the free antigen and thus to determine the interaction parameters (stoichiometry and binding constant) between an anionic polymeric adjuvant (polyacrylic acid, SPA09), and a cationic vaccine antigen in development for the treatment of Staphylococcus aureus. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00782DOI Listing

A Lamellar Structure in Alanine-Glycine Copolypeptides Studied by Solid-State NMR Spectroscopy: A Model for the Crystalline Domain of Silk Fibroin in Silk II Form.

Biomacromolecules 2020 Jun 30. Epub 2020 Jun 30.

silk fibroin (SF) fibers with excellent mechanical properties have attracted widespread attention as new biomaterials. However, the structural details are still not conclusive. We propose here a lamellar structure for the crystalline domain of SF fiber based on structural analyses of the Ala Cβ peaks in the C cross polarization/magic angle spinning NMR spectra of (Ala-Gly) (m = 9, 12, 15 and 25) and C selectively labeled (Ala-Gly) model peptides. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00486DOI Listing

Engineering nanogels for drug delivery to pathogenic fungi Aspergillus fumigatus by tuning polymer amphiphilicity.

Biomacromolecules 2020 Jun 30. Epub 2020 Jun 30.

Invasive aspergillosis (IA) is a serious threat to immunodeficient and critically ill patients caused mainly by the fungus Aspergillus fumigatus. Here, poly(glycidol) based nanogels (NGs) are proposed as delivery vehicles for antifungal agents for sustained drug release. NGs are formed by simple self-assembly of random copolymers followed by oxidative crosslinking of thiol functionalities. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00489DOI Listing

"Dumb" pH-Independent and Biocompatible Hydrogels Formed by Copolymers of Long-Chain Alkyl Glycidyl Ethers and Ethylene Oxide.

Biomacromolecules 2020 Jun 30. Epub 2020 Jun 30.

The formation and rheological properties of hydrogels based on amphiphilic ABA triblock polyether copolymers are described, relying solely on the hydrophobic interaction of long-chain alkyl glycidyl ether based A-blocks that are combined with a hydrophilic poly(ethylene glycol) midblock. Via anionic ring-opening copolymerization (AROP) ethylene oxide (EO) and long-chain alkyl glycidyl ethers (AlkGE) were copolymerized, using deprotonated poly(ethylene glycol) (PEG) macroinitiators (Mn of 10 kg mol-1, 20 kg mol-1). The polymerization afforded amphiphilic ABA triblock copolymers with molar masses in the range of 21 to 32 kg mol-1 and dispersities (Ð) of Ð = 1. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00576DOI Listing

Solubilization and stabilization of membrane proteins by cycloalkane-modified amphiphilic polymers.

Biomacromolecules 2020 Jun 30. Epub 2020 Jun 30.

Membrane proteins need to be extracted from biological membranes and purified in their native state for most structural and functional in vitro investigations. Amphiphilic copolymers, such as amphipols (APols), have emerged as very useful alternatives to detergents for keeping membrane proteins water-soluble under their native form. However, classical APols, i. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00929DOI Listing

PBS-based green copolymer as efficient compatibilizer in Thermoplastic inedible Wheat Flour/Poly (Butylene Succinate) Blends.

Biomacromolecules 2020 Jun 30. Epub 2020 Jun 30.

Considering the current context of researches aiming at proposing new bioplastics with low costs and properties similar to fossil-based commodities currently on the market, in the present work, a hybrid blend containing a prevalent amount of a cheap inedible cereal flour (70% wt.) and poly (butylene succinate) (PBS) (30% wt.) has been prepared by using a simple, eco-friendly and low cost processing methodology. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00701DOI Listing

Tuning Cellular Interactions of Carboxylic Acid Side Chain Containing Polyacrylates: The Role of Cyanine Dye Label and Side Chain Type.

Biomacromolecules 2020 Jun 29. Epub 2020 Jun 29.

Cellular uptake and intracellular targeting to specific organelles are key events in the cellular processing of nanomaterials. Herein, we perform a detailed structure-property relationship study on carboxylic acid side chain bearing polyacrylates in order to provide design criteria for the manipulation of their cellular interactions. Redox-initiated RAFT polymerization of three tert-butyl protected N-acylated amino ester based acrylate monomers of different substitution and degree of polymerization (DP) yielded defined and pH-responsive carboxylic acid side chain polymers upon deprotection (N-acetyl, DP 1: P(M1); N-propionyl, DP 1: P(E1), DP 2: P(E2)). Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00244DOI Listing

Synthesis and Properties of Mono- or Diamine Initiated Imidazolium-Based Cationic Polypeptides.

Biomacromolecules 2020 Jun 29. Epub 2020 Jun 29.

A series of cationic polypeptide imidazolium conjugates were prepared by ring-opening polymerization (ROP) of γ-4-(3-chloropropoxycarbonyl)benzyl-L- glutamic acid based N-carboxyanhydride (CPBLG-NCA) initiated by various mono- or diamine initiators and subsequent side-chain modification with high grafting efficiency. Rapid and controlled ROP was achieved by polymerize the CPBLG-NCA in dichloromethane/NaHCO3/H2O solvent mixture with the amine initiators. The resulting polypeptides bearing imidazolium iodide pendants showed reversible upper critical solution temperature (UCST)-type thermoresponsive properties in both ethanol and DI water while the polypeptides with tetrafluoroborate counter-anions showed a UCST in phosphate buffer saline (PBS). Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00953DOI Listing

Spontaneous self-assembly of thermo-responsive vesicles using a zwitterionic and an anionic surfactant.

Biomacromolecules 2020 Jun 29. Epub 2020 Jun 29.

Spontaneous formation of vesicles from the self-assembly of two specific surfactants - one zwitterionic (oleyl amidopropyl betaine, OAPB) and the other anionic (Aerosol-OT, AOT) - is explored in water using small-angle scattering techniques. Two factors were found to be critical in the formation of vesicles: surfactant ratio, as AOT concentrations less than equimolar with OAPB result in cylindrical micelles or mixtures of micellar structures, and salt concentration, whereby increasing the amount of NaCl promotes vesicle formation by reducing head-group repulsions. Small-angle neutron scattering measurements reveal that the vesicles are approximately 30-40~nm in diameter depending on sample composition. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00672DOI Listing

Polymersome Formation by Amphiphilic Polyglycerol-b-Polydisulfide-b-Polyglycerol and Glutathione Triggered Intracellular Drug Delivery.

Biomacromolecules 2020 Jun 26. Epub 2020 Jun 26.

This article reports synthesis, spontaneous self-assembly, highly efficient drug encapsulation and glutathione (GSH)-triggered intra-cellular sustained drug delivery of an ABA-type amphiphilic triblock copolymer namely polyglycerol-b-poly(disulfide)-b-polyglycerol (PG-b-PDS-b-PG). The bio-reducible PDS block with reactive pyridyldisulfide groups present at the chain terminals was attached with thiol terminated heterotelechelic PG by thiol-disulfide exchange reaction producing the amphiphilic PG-b-PDS-b-PG. It formed stable polymersome in aqueous medium with critical aggregation concentration of 0. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00775DOI Listing

Introducing Porosity in Colloidal Biocoatings to Increase Bacterial Viability.

Biomacromolecules 2020 Jun 25. Epub 2020 Jun 25.

A biocoating confines non-growing, metabolically-active bacteria within a synthetic colloidal polymer (i.e. latex) film. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00649DOI Listing

Adhesive Sponge Based on Supramolecular Dimers Interactions as Scaffolds for Neural Stem Cells.

Biomacromolecules 2020 Jun 25. Epub 2020 Jun 25.

Improving cell-material interactions of non-adhesive scaffolds is crucial for the success of biomaterials in tissue engineering. Due to their high surface area and open pore structure, sponges are widely reported as absorbent materials for biomedical engineering. The biocompatibility and biodegradability of polysaccharides sponges, coupled with the chemical functionalities of supramolecular dimers, make them promising combinations for the development of adhesive scaffolds. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00825DOI Listing

Dual antioxidant properties and organic radical stabilization in cellulose nanocomposite films functionalized by polymerization of coniferyl alcohol.

Biomacromolecules 2020 Jun 25. Epub 2020 Jun 25.

A new biobased material based on an original strategy using lignin model compounds as natural grafting additive on a nanocellulose surface through in situ polymerization of coniferyl alcohol by the Fenton reaction at two pH values was investigated. The structural and morphological properties of the materials at the nanoscale were characterized by a combination of analytical methods, including Fourier transform infrared (FTIR) spectroscopy, liquid chromatography combined with mass spectrometry (LC-MS), nuclear molecular resonance (NMR) spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, water sorption capacity by dynamic vapor sorption (DVS) and atomic force microscopy (AFM, topography and indentation modulus measurements). Finally, the usage properties, such as antioxidant properties, were evaluated in solution and from the nanostructured casted films by radical 2,2'-diphenyl-1-picrylhydrazyl (DPPH°) scavenging tests. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00583DOI Listing

Functional Hybrid Glyconanocapsules by a One-Pot Nanoprecipitation Process.

Biomacromolecules 2020 Jun 24. Epub 2020 Jun 24.

Herein, we report on one-pot fabrication of oil-filled nanocapsules wrapped with both RAFT-made glycopolymers and neutral polysaccharides (dextran and pullulan). We have made use of the nanoprecipitation technique, relying on coprecipitation of both oil and polymers in conditions thoroughly established from phase diagrams' interpretation. Mixed mono- or multi-layered nanocapsules were obtained through simultaneous or sequential nanoprecipitation, respectively. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00697DOI Listing

Natural Multimerization Rules the Performance of Affinity-Based Physical Hydrogels for Stem Cell Encapsulation and Differentiation.

Biomacromolecules 2020 Jul 7. Epub 2020 Jul 7.

UCIBIO, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus Caparica, 2829-516 Caparica, Portugal.

Tissue engineering and stem cell research greatly benefit from cell encapsulation within hydrogels as it promotes cell expansion and differentiation. Affinity-triggered hydrogels, an appealing solution for mild cell encapsulation, rely on selective interactions between the ligand and target and also on the multivalent presentation of these two components. Although these hydrogels represent a versatile option to generate dynamic, tunable, and highly functional materials, the design of hydrogel properties based on affinity and multivalency remains challenging and unstudied. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00473DOI Listing

Hydrogel-Colloid Composite Bioinks for Targeted Tissue-Printing.

Biomacromolecules 2020 Jun 22. Epub 2020 Jun 22.

Université Grenoble Alpes, Centre de Recherches sur les Macromolécules Végétales (CERMAV)-CNRS, 601, rue de la Chimie, BP 53, 38041 CEDEX 9 Grenoble, France.

The development of extrusion-based bioprinting for tissue engineering is conditioned by the design of bioinks displaying adequate printability, shape stability, and postprinting bioactivity. In this context, simple bioink formulations, made of cells supported by a polymer matrix, often lack the necessary versatility. To address this issue, intense research work has been focused on introducing colloidal particles into the ink formulation. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00305DOI Listing

Recent Advances of Polycationic siRNA Vectors for Cancer Therapy.

Biomacromolecules 2020 Jul 7. Epub 2020 Jul 7.

Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, PR China.

Small interfering RNAs (siRNAs) have recently emerged as a new class of biopharmaceuticals for the treatment of various diseases, including genetic diseases, viral infections, heritable disorders, and most prominently, cancer. However, clinical applications of siRNA-based therapeutics through intravenous administration have been limited due to their rapid degradation and renal clearance, poor cellular uptake, low cytoplasmic release by escaping endocytic uptake, and off-target effects. The success of siRNA-based therapeutics depends upon the design and creation of efficient delivery vectors that should be able to protect siRNA from degradation and specifically deliver siRNA to cytosol of target cells. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00438DOI Listing

Stabilizing Enzymes within Polymersomes by Co-Encapsulation of Trehalose.

Biomacromolecules 2020 Jun 22. Epub 2020 Jun 22.

Enzymes are essential biocatalysts and very attractive as therapeutics. However, their functionality is strictly related to their stability, which is significantly affected by the environmental changes occurring during their usage or long-term storage. Therefore, maintaining the activity of enzymes is essential when they are exposed to high temperature during usage, or when they are stored at room temperature or elevated temperature for extended periods of time. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00824DOI Listing

Thiolated chitosans - a multi-talented class of polymers for various applications.

Biomacromolecules 2020 Jun 22. Epub 2020 Jun 22.

Various properties of chitosan can be customized by thiolation for very specific needs in a wide range of application areas. Since the discovery of thiolated chitosans, many studies have proven their advantageous characteristics such as adhesion to biological surfaces, adjustable crosslinking and swelling behavior, controllable drug release, permeation as well as cellular uptake enhancement, inhibition of efflux pumps and enzymes, complexation of metal ions, antioxidative properties and radical scavenging activity. Simultaneously, these polymers remain biodegradable without increased toxicity. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00663DOI Listing

Determining How Human Mesenchymal Stem Cells Change Their Degradation Strategy in Response to Microenvironmental Stiffness.

Biomacromolecules 2020 Jul 6. Epub 2020 Jul 6.

Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, Pennsylvania 18015, United States.

During the wound healing process, human mesenchymal stem cells (hMSCs) are recruited to the injury where they regulate inflammation and initiate healing and tissue regeneration. To aid in healing, synthetic cell-laden hydrogel scaffolds are being designed to deliver additional hMSCs to wounds to enhance or restart the healing process. These scaffolds are being designed to mimic native tissue environments, which include physical cues, such as scaffold stiffness. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00432DOI Listing

Photodegradable Hydrogels for Rapid Screening, Isolation, and Genetic Characterization of Bacteria with Rare Phenotypes.

Biomacromolecules 2020 Jul 6. Epub 2020 Jul 6.

Division of Biology, Kansas State University, Manhattan, Kansas 66506, United States.

Screening mutant libraries (MLs) of bacteria for strains with specific phenotypes is often a slow and laborious process that requires assessment of tens of thousands of individual cell colonies after plating and culturing on solid media. In this report, we develop a three-dimensional, photodegradable hydrogel interface designed to dramatically improve the throughput of ML screening by combining high-density cell culture with precision extraction and the recovery of individual, microscale colonies for follow-up genetic and phenotypic characterization. ML populations are first added to a hydrogel precursor solution consisting of polyethylene glycol (PEG) -nitrobenzyl diacrylate and PEG-tetrathiol macromers, where they become encapsulated into 13 μm thick hydrogel layers at a density of 90 cells/mm, enabling parallel monitoring of 2. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00543DOI Listing

RAFT Emulsion Polymerization: MacroRAFT Agent Self-Assembly Investigated Using a Solvachromatic Dye.

Biomacromolecules 2020 Jul 6. Epub 2020 Jul 6.

Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, The University of New South Wales, Sydney, New South Wales 2052, Australia.

Polymerization-induced self-assembly (PISA) and amphiphilic-macroRAFT-mediated emulsion polymerization are commonly used approaches for synthesis of well-defined polymers and sophisticated particle morphologies. One aspect of these systems that remains relatively unexplored is the conformational state of macroRAFT agents in aqueous solution. To redress this deficiency, we have used fluorescence spectrometry experiments to conduct detailed investigations of the coil conformation across a wide range of pH values for a series of poly(acrylic acid) (PAA) and poly(methacrylic acid) (PMAA) macroRAFT agents with different Z-groups (-S-(CH)-COOH, -S-(CH)-CH, and -S-(CH)-CH), as well as amphiphilic macroRAFT agents (PMAA--poly(methyl methacrylate)(PMMA) and PAA--polystyrene(PS)). Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00685DOI Listing

Enzymatic Polymerization of Poly(glycerol-1,8-octanediol-sebacate): Versatile Poly(glycerol sebacate) Analogues that Form Monocomponent Biodegradable Fiber Scaffolds.

Biomacromolecules 2020 Jul 7. Epub 2020 Jul 7.

Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.

A family of poly(glycerol sebacate) (PGS) analogues were synthesized by lipase B (CALB) catalysis to tailor biomaterial properties. Different fractions of glycerol (G) units in PGS were replaced by 1,8-octanediol (O) units. Poly(glycerol-1,8-octanediol-sebacate), PGOS, synthesized by CALB catalysis with a 1:3 molar ratio of G to O units has and values of 9500 and 92,000, respectively. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00641DOI Listing

Plasmonic Enhancement of Two-Photon Excitation Fluorescence by Colloidal Assemblies of Very Small AuNPs Templated on M13 Phage.

Biomacromolecules 2020 Jul 1. Epub 2020 Jul 1.

EMT Research Center, Institut National de la Recherche Scientifique (INRS), Varennes, Quebec J3X 1S2, Canada.

In this study, an engineered M13 bacteriophage was examined as a biological template to create a well-defined spacing between very small gold nanoparticles (AuNPs 3-13 nm). The effect of the AuNP particle size on the enhancement of the nonlinear process of two-photon excitation fluorescence (2PEF) was investigated. Compared to conventional (one-photon) microscopy techniques, such nonlinear processes are less susceptible to scattering given that the density of background-scattered photons is too low to generate a detectable signal. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00401DOI Listing

Synergetic Effect of Water-Soluble PEG-Based Macromonomers and Cellulose Nanocrystals for the Stabilization of PMMA Latexes by Surfactant-Free Emulsion Polymerization.

Biomacromolecules 2020 Jul 6. Epub 2020 Jul 6.

Univ Lyon, Université Claude Bernard Lyon 1, CPE Lyon, CNRS, UMR 5265, Chemistry, Catalysis, Polymers and Processes (C2P2), 43 Bd du 11 Novembre 1918, 69616 Villeurbanne, France.

The combination of cellulose nanocrystals (CNCs) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) was evaluated to synthesize stable latexes by surfactant-free emulsion polymerization of methyl methacrylate (MMA). Cellulose-particle interaction was provided due to the dual role of PEGMA, acting as water-soluble comonomer with MMA under emulsion polymerization conditions and able to interact with CNCs, recovered from sulfuric acid hydrolysis (HSO-CNCs). After preliminary experiments designed to validate the affinity between CNCs and PEG-stabilized PMMA particles obtained by MMA/PEGMA emulsion copolymerization, the effect of the PEGMA content and molar mass and also of the content of CNCs on the kinetics of the polymerization and the stability of the latexes were investigated. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00439DOI Listing

Lipase-Catalyzed Ring-Opening Polymerization of Benzyl Malolactonate: An Unusual Mechanism?

Biomacromolecules 2020 Jun 30. Epub 2020 Jun 30.

Univ Rennes, ENSCR, CNRS, ISCR (Institut des Sciences Chimiques de Rennes) - UMR 6226, F-35000 Rennes, France.

The use of safe natural catalyst such as enzymes for ring opening polymerization (ROP) of β-substituted β-lactones such as benzyl malolactonate (MLABe) is an important objective considering the biomedical applications of the resulting (co)polymers. However, the preparation of well-defined polymeric materials using such systems requires an understanding of enzyme-substrate interactions. In this context, we investigated the mechanism of lipase-catalyzed ROP of MLABe, because it appears that it is probably not the same as the one widely described for other lactones such ε-caprolactone, propiolactone. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00593DOI Listing

Structural Diversity of Native Major Ampullate, Minor Ampullate, Cylindriform, and Flagelliform Silk Proteins in Solution.

Biomacromolecules 2020 Jul 8. Epub 2020 Jul 8.

Pure and Applied Biochemistry, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden.

The foundations of silk spinning, the structure, storage, and activation of silk proteins, remain highly debated. By combining solution small-angle neutron and X-ray scattering (SANS and SAXS) alongside circular dichroism (CD), we reveal a shape anisotropy of the four principal native spider silk feedstocks from . We show that these proteins behave in solution like elongated semiflexible polymers with locally rigid sections. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00819DOI Listing

Bio-Based Lignin Nanocarriers Loaded with Fungicides as a Versatile Platform for Drug Delivery in Plants.

Biomacromolecules 2020 Jun 30. Epub 2020 Jun 30.

Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany.

Lignin-based nano- and microcarriers are a promising biodegradable drug delivery platform inside of plants. Many wood-decaying fungi are capable of degrading the wood component lignin by segregated lignases. These fungi are responsible for severe financial damage in agriculture, and many of these plant diseases cannot be treated today. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00487DOI Listing

Review on Magnetic Natural Polymer Constructed Hydrogels as Vehicles for Drug Delivery.

Biomacromolecules 2020 Jun 28. Epub 2020 Jun 28.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.

Hydrogels prepared from natural polymers have captured extensive attention over the past decades because of their exceptional biocompatibility and nontoxicity, ease of gelation, and functionalization. Thus, natural polymer hydrogels are considered as promising biomaterials that show great potential in the biomedical field. In drug-delivery systems, the extent and the rate with which the drugs reach their targets are highly carrier-dependent, so the demand for intelligent drug-delivery systems is gradually increasing. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00566DOI Listing

Biological Route to Fabricate Silica on Cellulose Using Immobilized Silicatein Fused with a Carbohydrate-Binding Module.

Biomacromolecules 2020 Jun 26. Epub 2020 Jun 26.

Division of Sustainable Resources Engineering, Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-Ku, Sapporo 060-8628, Japan.

Silicatein is an enzyme capable of catalyzing silica formation under mild conditions and is a promising catalyst for the fabrication of biohybrid materials. However, unfavorable aggregation of silicatein makes it unsuitable for use in material fabrication. In this study, a soluble protein tag (ProS2) and a carbohydrate-binding module (CBM) were used to develop a soluble and cellulose-binding fusion silicatein, ProS2-Sil-CBM, which can be efficiently immobilized on cellulose to form silica on it. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00730DOI Listing

Temperature-Switchable Glycopolymers and Their Conformation-Dependent Binding to Receptor Targets.

Biomacromolecules 2020 Jun 25. Epub 2020 Jun 25.

Institute of Organic and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf, Universitätsstraße 1, Dusseldorf 40225, Germany.

The temperature-dependent binding of copolymers from poly(-isopropylacrylamide) (PNIPAM) and mannose ligands to and concanavalin A (ConA) is determined. Through polymer analogous reactions using poly(-acryloxysuccinimide) and amine-linked mannose residues with different linkers, glycopolymers are prepared with the variation of the mannose density. Quantitative adhesion inhibition assays show the inhibitory potential of the glycopolymers as a function of the mannose/NIPAM ratio and linker type above and below their lower critical solution temperature (LCST). Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00676DOI Listing

Fundamentals of Emulsion Polymerization.

Biomacromolecules 2020 Jun 16. Epub 2020 Jun 16.

A comprehensive overview of the fundamentals of emulsion polymerization and related processes is presented with the object of providing theoretical and practical understanding to researchers considering use of these methods for synthesis of polymer colloids across a wide range of applications. Hence, the overview has been written for a general scientific audience with no prior knowledge assumed. Succinct introductions are given to key topics of background science to assist the reader. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00769DOI Listing

Biodegradable Polymer Theranostic Fluorescent Nanoprobe for Direct Visualization and Quantitative Determination of Antimicrobial Activity.

Biomacromolecules 2020 Jun 30. Epub 2020 Jun 30.

We report a biodegradable fluorescent theranostic nanoprobe design strategy for simultaneous visualization and quantitative determination of antibacterial activity for the treatment of bacterial infections. Cationic-charged polycaprolactone (PCL) was tailor-made through ring-opening polymerization methodology, and it was self-assembled into well-defined tiny 5.0 ± 0. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00653DOI Listing

2,5-Anhydro-d-Mannose End-Functionalized Chitin Oligomers Activated by Dioxyamines or Dihydrazides as Precursors of Diblock Oligosaccharides.

Biomacromolecules 2020 Jun 26. Epub 2020 Jun 26.

NOBIPOL, Department of Biotechnology and Food Science, NTNU - Norwegian University of Science and Technology, Sem Saelands veg 6/8, NO-7491 Trondheim, Norway.

Diblock oligosaccharides based on renewable resources allow for a range of new but, so far, little explored biomaterials. Coupling of blocks through their reducing ends ensures retention of many of their intrinsic properties that otherwise are perturbed in classical lateral modifications. Chitin is an abundant, biodegradable, bioactive, and self-assembling polysaccharide. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00620DOI Listing

Short- and Long-Term Effects of X-ray Synchrotron Radiation on Cotton Paper.

Biomacromolecules 2020 Jun 30. Epub 2020 Jun 30.

Centre de Recherche sur la Conservation des Collections (CRC, CNRS USR 3224), Muséum National d'Histoire Naturelle, 36 rue Geoffroy St Hilaire, 75005 Paris, France.

X-ray analytical techniques are increasingly being used to study manuscripts and works of art on paper, whether with laboratory equipment or synchrotron sources. However, it is difficult to anticipate the impact of X-ray photons on paper- and cellulose-based artifacts, particularly due to the large variety of their constituents and degradation levels, and the subsequent material multiscale heterogeneity. In this context, this work aims at developing an analytical approach to study the modifications in paper upon synchrotron radiation (SR) X-ray radiation using analytical techniques, which are fully complementary and highly sensitive, yet not frequently used together. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00512DOI Listing

Synthesis and Characterization of Silk Ionomers for Layer-by-Layer Electrostatic Deposition on Individual Mammalian Cells.

Biomacromolecules 2020 Jun 24. Epub 2020 Jun 24.

Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, United States.

Nanocoating of individual mammalian cells with polymer layers has been of increasing interest in biotechnology and biomedical engineering applications. Electrostatic layer-by-layer (LbL) deposition of polyelectrolytes on negatively charged cell surfaces has been utilized for cell nanocoatings using synthetic or natural polymers with a net charge at physiological conditions. Here, our previous synthesis of silk-based ionomers through modification of silk fibroin (SF) with polyglutamate (PG) and polylysine (PL) was exploited for the nanocoating of mammalian cells. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00523DOI Listing

Polysaccharide-Based pH-Responsive Nanocapsules Prepared with Bio-Orthogonal Chemistry and Their Use as Responsive Delivery Systems.

Biomacromolecules 2020 Jun 24. Epub 2020 Jun 24.

Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany.

Bio-orthogonal reactions have become an essential tool to prepare biomaterials; for example, in the synthesis of nanocarriers, bio-orthogonal chemistry allows circumventing common obstacles related to the encapsulation of delicate payloads or the occurrence of uncontrolled side reactions, which significantly limit the range of potential payloads to encapsulate. Here, we report a new approach to prepare pH-responsive nanocarriers using dynamic bio-orthogonal chemistry. The reaction between a poly(hydrazide) crosslinker and functionalized polysaccharides was used to form a pH-responsive hydrazone network. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00492DOI Listing

Hydroxamic Acid: An Underrated Moiety? Marrying Bioinorganic Chemistry and Polymer Science.

Biomacromolecules 2020 Jun 29. Epub 2020 Jun 29.

Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, D-55124 Mainz, Germany.

Even 150 years after their discovery, hydroxamic acids are mainly known as the starting material for the Lossen rearrangement in textbooks. However, hydroxamic acids feature a plethora of existing and potential applications ranging from medical purposes to materials science, based on their excellent complexation properties. This underrated functional moiety can undergo a broad variety of organic transformations and possesses unique coordination properties for a large variety of metal ions, for example, Fe(III), Zn(II), Mn(II), and Cr(III). Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00449DOI Listing

Second-Generation Dendrimers with Chondroitin Sulfate Type-E Disaccharides as Multivalent Ligands for Langerin.

Biomacromolecules 2020 Jun 24. Epub 2020 Jun 24.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Centro de Investigaciones Científicas Isla de La Cartuja, CSIC and Universidad de Sevilla, Américo Vespucio, 49, 41092 Sevilla, Spain.

Chondroitin sulfate type-E (CS-E) is a sulfated polysaccharide that shows several interesting biological activities, such as modulation of the neuronal growth factor signaling and its interaction with langerin, a C-type lectin with a crucial role in the immunological system. However, applications of CS-E are hampered by the typical heterogeneous structure of the natural polysaccharide. Well-defined, homogeneous CS-E analogues are highly demanded. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00476DOI Listing

Vesicle-Templated Polymerization, a Review.

Biomacromolecules 2020 Jun 19. Epub 2020 Jun 19.

Institute of Chemical and Engineering Sciences, Singapore 627833.

Vesicle-templated polymerization has developed into a mature research area over the last 35 years. The main purpose of this approach was to produce hollow polymeric nanocapsules from low-cost chemicals, utilizing a simple emulsion-polymerization-like process. Over the years, understanding of the different varieties of the approach has grown. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00558DOI Listing

Radical Aqueous Emulsion Copolymerization of Eugenol-Derived Monomers for Adhesive Applications.

Biomacromolecules 2020 Jun 24. Epub 2020 Jun 24.

ICGM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.

Biobased monomers derived from eugenol were copolymerized by emulsion polymerization to produce latexes for adhesive applications. Stable latexes containing ethoxy dihydroeugenyl methacrylate and ethoxy eugenyl methacrylate with high total solids content of 50 wt % were obtained and characterized. Latexes synthesis was carried out using a semibatch process, and latexes with particle diameters in the range of 159-178 nm were successfully obtained. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00461DOI Listing

Exploring the Impact of Morphology on the Properties of Biodegradable Nanoparticles and Their Diffusion in Complex Biological Medium.

Biomacromolecules 2020 Jun 26. Epub 2020 Jun 26.

Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600 MB Eindhoven, The Netherlands.

Nanoparticle morphology (size, shape, and composition) and surface chemistry are the determining factors underpinning the efficacy of such materials in therapeutic applications. The size, shape, and surface chemistry of a nanoparticle can strongly influence key properties such as interactions with diverse biological fluids and interfaces and, in turn, impact the delivery of bioactive cargo, modulating therapeutic performance. This is exemplified in ocular drug delivery, where potential therapeutics must navigate complex biological media such as the gel-like vitreal fluid and the retina. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00726DOI Listing

Welcome to Our New Associate Editors.

Biomacromolecules 2020 Jun;21(6):1963-1965

Univ. Bordeaux, CNRS, Bordeaux INP, LCPO, UMR 5629, Pessac, F-33600, France.

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http://dx.doi.org/10.1021/acs.biomac.0c00577DOI Listing