60,891 results match your criteria Biology of mood & anxiety disorders[Journal]


Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization.

Phys Biol 2019 Apr 23;16(4):046004. Epub 2019 Apr 23.

The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London WC1 6BT, United Kingdom.

Active networks composed of filaments and motor proteins can self-organize into a variety of architectures. Computer simulations in two or three spatial dimensions and including or omitting steric interactions between filaments can be used to model active networks. Here we examine how these modelling choices affect the state space of network self-organization. Read More

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http://dx.doi.org/10.1088/1478-3975/ab0fb1DOI Listing

Nandrolone decanoate and resistance exercise affect prostate morphology and hormone receptor interface in adult rats with implications for the aging process.

Andrology 2019 Apr 22. Epub 2019 Apr 22.

Department of Anatomy, Institute of Biosciences, University of Estadual Paulista (UNESP), Botucatu, SP, Brazil.

Background: Nandrolone decanoate (ND) is an anabolic-androgenic steroid, and its indiscriminate use leads to subclinical alterations in the hypothalamic-pituitary-gonadal axis and androgen-dependent organs.

Objectives: To evaluate the effects of ND, either alone or in combination with resistance exercise (RE), on the levels of sex hormones, converting enzymes, and steroid receptors and the morphology of the ventral prostate (VP) in adult and aged rats.

Methods: Forty Sprague-Dawley adult and aged rats were divided into four groups each, sedentary and trained with and without ND. Read More

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http://dx.doi.org/10.1111/andr.12626DOI Listing

Metagenome to phenome approach enables isolation and genomics characterization of Kalamiella piersonii gen. nov., sp. nov. from the International Space Station.

Appl Microbiol Biotechnol 2019 Apr 23. Epub 2019 Apr 23.

Jet Propulsion Laboratory, Biotechnology and Planetary Protection Group, M/S 89-2, California Institute of Technology, 4800 Oak Grove Dr, Pasadena, CA, 91109, USA.

Several evolutionarily distinct, near full-length draft metagenome-resolved genomes (MRG), were assembled from sequences recovered from the International Space Station (ISS) environments. The retrieval of MRGs facilitated the exploration of a large collection of archived strains (~ 500 isolates) and assisted in isolating seven related strains. The whole genome sequences (WGS) of seven ISS strains exhibited 100% identity to the 4. Read More

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http://dx.doi.org/10.1007/s00253-019-09813-zDOI Listing

Improvement of growth and yield of soybean plants through the application of non-thermal plasmas to seeds with different health status.

Heliyon 2019 Apr 13;5(4):e01495. Epub 2019 Apr 13.

Instituto de Investigaciones en Biociencias Agrícolas y Ambientales (INBA), Facultad de Agronomía, Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, 4453, Buenos Aires, Argentina.

Soybean ( (L.) Merrill) is a globally important crop, providing oil and protein. complex includes seed-borne pathogens that affect this legume. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183899
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http://dx.doi.org/10.1016/j.heliyon.2019.e01495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462543PMC
April 2019
1 Read

Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer.

Mol Ther Oncolytics 2019 Sep 20;14:57-65. Epub 2019 Mar 20.

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA.

Oral radiotoxicity is often a limiting factor in cancer treatment. Previously, we demonstrated that transfer of cell-permeable, TAT-fusion Tousled-like kinase 1B (TLK1B) protein in salivary glands effectively mitigates radiation-induced salivary dysfunction. However, similar to most radioprotectors, TLK1B can carry the risk of limiting cancer treatment efficacy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23727705193001
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http://dx.doi.org/10.1016/j.omto.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463741PMC
September 2019
1 Read

Antibodies against Angiotensin II Type 1 and Endothelin A Receptors: Relevance and pathogenicity.

Hum Immunol 2019 Apr 19. Epub 2019 Apr 19.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Antibodies against two G-protein coupled receptors (GPCRs), angiotensin II type 1 receptor (AT1R) and endothelin A receptor (ETAR) are among a growing number of autoantibodies that are found to be associated with allograft dysfunction. AT1R antibodies (AT1Rabs) and ETAR antibodies (ETARabs) have been shown to activate their target receptors and affect signaling pathways. Multiple single center reports have shown an association between presence of these antibodies and acute or chronic rejection and graft loss in kidney, heart, liver, lung and composite tissue transplantations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01988859193013
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http://dx.doi.org/10.1016/j.humimm.2019.04.012DOI Listing
April 2019
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Crystal structure of phyllogen, a phyllody-inducing effector protein of phytoplasma.

Biochem Biophys Res Commun 2019 Apr 17. Epub 2019 Apr 17.

Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.

Phytoplasmas are plant pathogenic bacteria that often induce unique phyllody symptoms in which the floral organs are transformed into leaf-like structures. Recently, a novel family of bacterial effector genes, called phyllody-inducing genes (phyllogens), was identified as being involved in the induction of phyllody by degrading floral MADS-domain transcription factors (MTFs). However, the structural characteristics of phyllogens are unknown. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.060DOI Listing

Silencing FOXO1 attenuates dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells.

Biochem Biophys Res Commun 2019 Apr 19. Epub 2019 Apr 19.

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Department of Bone Metabolism, School of Stomatology Shandong University, Jinan, 250012, China. Electronic address:

Dexamethasone (DEX), a widely used glucocorticoid with strong anti-inflammatory and immunosuppressive activities, has been reported to induce apoptosis in osteoblasts, but the underlying mechanisms are still not comprehensively investigated. FOXO1 plays an important role in the regulation of cell proliferation and apoptosis. Our study aims to explore the role of FOXO1 in DEX-induced apoptosis of osteoblastic MC3T3-E1 cells through bioinformatics and experiments. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.112DOI Listing

Contrasting responses of the coral Acropora tenuis to moderate and strong light limitation in coastal waters.

Mar Environ Res 2019 Apr 12. Epub 2019 Apr 12.

Australian Institute of Marine Science, PMB #3, Townsville MC, QLD, 4810, Australia.

Coastal water quality and light attenuation can detrimentally affect coral health. This study investigated the effects of light limitation and reduced water quality on the physiological performance of the coral Acropora tenuis. Branches of individual colonies were collected in 2 m water depth at six inshore reefs at increasing distances from major river sources in the Great Barrier Reef, along a strong water quality gradient in the Burdekin and a weak gradient in the Whitsunday region. Read More

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http://dx.doi.org/10.1016/j.marenvres.2019.04.003DOI Listing

Plasma-Coated Polycaprolactone Nanofibers with Covalently Bonded Platelet-Rich Plasma Enhance Adhesion and Growth of Human Fibroblasts.

Nanomaterials (Basel) 2019 Apr 19;9(4). Epub 2019 Apr 19.

Scientific Institute of Clinical and Experimental Lymphology-Branch of the ICG SB RAS, 2 Timakova str., 630060 Novosibirsk, Russia.

Biodegradable nanofibers are extensively employed in different areas of biology and medicine, particularly in tissue engineering. The electrospun polycaprolactone (PCL) nanofibers are attracting growing interest due to their good mechanical properties and a low-cost structure similar to the extracellular matrix. However, the unmodified PCL nanofibers exhibit an inert surface, hindering cell adhesion and negatively affecting their further fate. Read More

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http://dx.doi.org/10.3390/nano9040637DOI Listing

Oncogenic Role of ZFAS1 lncRNA in Head and Neck Squamous Cell Carcinomas.

Cells 2019 Apr 21;8(4). Epub 2019 Apr 21.

Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, 15 Garbary Street, 61-866 Poznan, Poland.

Background: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with high mortality. The identification of specific HNSCC biomarkers will increase treatment efficacy and limit the toxicity of current therapeutic strategies. Long non-coding RNAs (lncRNAs) are promising biomarkers. Read More

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http://dx.doi.org/10.3390/cells8040366DOI Listing

A 2-year Double-Blind RCT Follow-up Study with Fermented Papaya Preparation (FPP) Modulating Key Markers in Middle-Age Subjects with Clustered Neurodegenerative Disease-Risk Factors.

Clin Pharmacol Biopharm 2017 18;6. Epub 2017 May 18.

Department of Internal Medicine, University of Catania, Catania, Italy.

In recent years a number of studies have reported the significant relationship between metabolic syndrome and neurodegenerative disease. There is accumulating evidence that the interplay of combined genetic and environmental risk factors (from diet to life style to pollutants) to intrinsic age-related oxi-inflammatory changes may be advocated for to explain the pandemic of neurodegenerative diseases. In recent years a specific Fermented Papaya Preparation (FPP) has been shown to significantly affect a number of redox signalling abnormalities in a variety of chronic diseases and as well in aging mechanisms either on experimental and on clinical ground. Read More

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http://dx.doi.org/10.4172/2167-065X.1000170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474671PMC

Socio-environmental consideration of phosphorus flows in the urban sanitation chain of contrasting cities.

Reg Environ Change 2018 19;18(5):1387-1401. Epub 2017 Dec 19.

11Department of Earth Sciences, Geochemistry, Faculty of Geosciences, Utrecht University, Utrecht, The Netherlands.

Understanding how cities can transform organic waste into a valuable resource is critical to urban sustainability. The capture and recycling of phosphorus (P), and other essential nutrients, from human excreta is particularly important as an alternative organic fertilizer source for agriculture. However, the complex set of socio-environmental factors influencing urban human excreta management is not yet sufficiently integrated into sustainable P research. Read More

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http://dx.doi.org/10.1007/s10113-017-1257-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448357PMC
December 2017

Functional microglia neurotransmitters in amyotrophic lateral sclerosis.

Semin Cell Dev Biol 2019 Apr 19. Epub 2019 Apr 19.

Fondazione Santa Lucia IRCCS, Preclinical Neuroscience, Via Del Fosso di Fiorano 64, 00143, Rome, Italy. Electronic address:

Today neuroscience is dominated by the perspective that microglia are essential elements in any integrated view of the nervous system. A number of different neuroinflammatory conditions affect the CNS where microglia involvement, and particularly microgliosis, is not only a prominent feature, but also a pathogenic key mechanism of disease. On the other side, microglia can also constitute an important trigger of neuronal protection during neurodegenerative disorders. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.04.014DOI Listing
April 2019
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Untargeted LC-MS-based metabonomics revealed that aristolochic acid I induces testicular toxicity by inhibiting amino acids metabolism, glucose metabolism, β-oxidation of fatty acids and the TCA cycle in male mice.

Toxicol Appl Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Chinese Academy of Inspection and Quarantine, Institute of Chemicals Safety, Beijing, China. Electronic address:

As the main toxic component of aristolochic acid, aristolochic acid I (AAI) is primarily found in Aristolochiaceae plants such as Aristolochia, Aristolochia fangchi and Caulis aristolochiae manshuriensis. AAI has been proven to be carcinogenic, mutagenic and nephrotoxic. Although the role of AAI in testicular toxicity has been reported, its mechanism of action is unknown. Read More

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http://dx.doi.org/10.1016/j.taap.2019.04.014DOI Listing

Altering the levels of nuclear import factors in early Xenopus laevis embryos affects later development.

PLoS One 2019 22;14(4):e0215740. Epub 2019 Apr 22.

Department of Molecular Biology, University of Wyoming, Laramie, Wyoming, United States of America.

More than just a container for DNA, the nuclear envelope carries out a wide variety of critical and highly regulated cellular functions. One of these functions is nuclear import, and in this study we investigate how altering the levels of nuclear transport factors impacts developmental progression and organismal size. During early Xenopus laevis embryogenesis, the timing of a key developmental event, the midblastula transition (MBT), is sensitive to nuclear import factor levels. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215740PLOS

Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy.

Authors:
Aaron DiAntonio

Pain 2019 May;160 Suppl 1:S17-S22

Department of Developmental Biology, Washington University Medical School Saint Louis, Saint Louis, MO, United States.

Peripheral neuropathy is the most common neurodegenerative disease affecting hundreds of millions of patients worldwide and is an important cause of chronic pain. Typical peripheral neuropathies are characterized by dysesthesias including numbness, crawling skin, a sensation of "pins and needles," and burning and stabbing pain. In addition, peripheral neuropathy can affect the motor and autonomic systems leading to symptoms such as weakness, constipation, and dysregulation of blood pressure. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001528DOI Listing

Response of photosynthesis, growth and water relations of a savannah-adapted tree and grass grown across high to low CO2.

Ann Bot 2019 Apr 22. Epub 2019 Apr 22.

Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK.

Background And Aims: By the year 2100, atmospheric CO2 concentration ([CO2]a) could reach 800 ppm, having risen from ~200 ppm since the Neogene, beginning ~24 Myr ago. Changing [CO2]a affects plant carbon-water balance, with implications for growth, drought tolerance and vegetation shifts. The evolution of C4 photosynthesis improved plant hydraulic function under low [CO2]a and preluded the establishment of savannahs, characterized by rapid transitions between open C4-dominated grassland with scattered trees and closed forest. Read More

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http://dx.doi.org/10.1093/aob/mcz048DOI Listing

AXL knockdown gene signature reveals a drug repurposing opportunity for a class of antipsychotics to reduce growth and metastasis of triple-negative breast cancer.

Oncotarget 2019 Mar 12;10(21):2055-2067. Epub 2019 Mar 12.

Montreal Clinical Research Institute (IRCM), Montréal, QC, H2W 1R7, Canada.

Triple-Negative Breast Cancer (TNBC) is an aggressive cancer subtype that is associated with a poor prognosis due to its propensity to form metastases. The receptor tyrosine kinase AXL plays a role in tumor cell dissemination and its expression in breast cancers correlates with poor patient survival. Here, we explored whether already used drugs might elicit a gene signature similar to that seen with AXL knockdown in TNBC cells and which could, therefore, offer an opportunity for drug repurposing. Read More

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http://dx.doi.org/10.18632/oncotarget.26725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459349PMC

Web-based application for threatened woodland caribou population modeling.

Wildl Soc Bull 2019 Mar 5;43(1):167-177. Epub 2019 Mar 5.

Alberta Environment and Parks - Operations Division 1601 Provincial Building, 10320-99 Street Grande Prairie AB T8V 6J4 Canada.

Woodland caribou () are threatened in Canada, with population and distribution declines evident in most regions of the country. Causes of declines are linked to landscape change from forest fires and human development, notably forestry oil and gas activities, which result in caribou habitat loss and affect ecosystem food webs. The Federal Species at Risk Act requires effective protection and restoration of caribou habitat, with actions to increase caribou survival. Read More

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http://dx.doi.org/10.1002/wsb.950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472330PMC

Tropical Vegetable Oils Do Not Alter Growth Performance in African Catfish through a High n-6 Polyunsaturated Fatty Acids Biosynthesis Capacity.

Lipids 2019 Apr 22. Epub 2019 Apr 22.

University of Namur, Institute of Life, Earth and Environment (ILEE), Research Unit in Environmental and Evolutionary Biology (URBE), Rue de Bruxelles 61, B-5000, Namur, Belgium.

The main objective of this study was to determine the best vegetable oils (VO) for nutrition of African catfish by assessing the effects of a complete replacement of fish oil (FO) by different VO sources on its growth performance, fatty acid composition, and elongase-desaturase gene expression levels. Fish (16.2 g of initial body weight) were fed with five experimental isonitrogenous, isolipidic, and isoenergetic diets in which FO was totally replaced by cottonseed oil (CO), palm oil (PO), desert date oil (DO), or Shea butter (SB). Read More

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http://dx.doi.org/10.1002/lipd.12145DOI Listing

MORC3 Is a Target of the Influenza A Viral Protein NS1.

Structure 2019 Mar 29. Epub 2019 Mar 29.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

Microrchidia 3 (MORC3), a human ATPase linked to several autoimmune disorders, has been characterized both as a negative and positive regulator of influenza A virus. Here, we report that the CW domain of MORC3 (MORC3-CW) is targeted by the C-terminal tail of the influenza H3N2 protein NS1. The crystal structure of the MORC3-CW:NS1 complex shows that NS1 occupies the same binding site in CW that is normally occupied by histone H3, a physiological ligand of MORC3-CW. Read More

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http://dx.doi.org/10.1016/j.str.2019.03.015DOI Listing

Demographic senescence and effects on population dynamics of a perennial plant.

Ecology 2019 Apr 21:e02742. Epub 2019 Apr 21.

Department of Biology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.

Demographic rates in plants are usually assumed to be more stage or size dependent than age dependent, and aging is therefore not considered in demographic models. However, little is known about the effect of age on demographic rates, as there still are few studies based on long-term individual-based plant population data that consider both individual age and size. In addition, little is known about how aging of individuals may affect population dynamics. Read More

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http://dx.doi.org/10.1002/ecy.2742DOI Listing
April 2019
2 Reads

The involvement of ventral hippocampal microglial cells, but not cannabinoid CB1 receptors, in morphine-induced analgesia in rats.

Acta Neurol Belg 2019 Apr 20. Epub 2019 Apr 20.

Department of Animal Biology, School of Biology, College of Science, University of Tehran, 4155-6455, Tehran, Iran.

It is well known that glial cells are involved in pain processing. The purpose of the present study was to investigate the possible involvement of the ventral hippocampal (VH) glial cells in morphine-induced analgesia. A tail-flick apparatus was used to measure pain sensitivity in male Wistar rats that were bilaterally cannulated in the VH by stereotaxic surgery. Read More

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http://dx.doi.org/10.1007/s13760-019-01144-0DOI Listing

Lead toxicity in seawater teleosts: A morphofunctional and ultrastructural study on the gills of the Ornate wrasse (Thalassoma pavo L.).

Aquat Toxicol 2019 Apr 12;211:193-201. Epub 2019 Apr 12.

Department of Biology, Ecology and Earth Science, University of Calabria, Via P. Bucci 4/B, Rende, Cosenza, 87036, Italy. Electronic address:

Lead is one of the most alarming toxic pollutants for the environment due to its acute toxicity and high bioaccumulation tendency. Despite legislative efforts, world lead production has more than doubled since the early 1970s to 2016. Due to extensive exploitation and human activity, the coastal and estuarine regions belong to marine environments that are mostly and more rapidly deteriorated by pollutants including lead. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.04.009DOI Listing
April 2019
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Absence of mitochondrial DNA methylation in mouse oocyte maturation, aging and early embryo development.

Biochem Biophys Res Commun 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, PR China; University of Chinese Academy of Sciences, Beijing, 100101, PR China. Electronic address:

Mitochondrial DNA (mtDNA) is important for oxidative phosphorylation; dysfunctions can play a role in many mitochondrial diseases and can also affect the aging of cells and individuals. DNA methylation is an important epigenetic modification that plays a critical role in regulating gene expression. While recent studies have revealed the existence of mtDNA methylation there are still controversies about mtDNA methylation due to the special structure of mtDNA. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.100DOI Listing
April 2019
3 Reads

Genetic effects of welding fumes on the development of respiratory system diseases.

Comput Biol Med 2019 Apr 8;108:142-149. Epub 2019 Apr 8.

Bone Biology Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; Discipline of Pathology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia. Electronic address:

Background: The welding process releases potentially hazardous gases and fumes, mainly composed of metallic oxides, fluorides and silicates. Long term welding fume (WF) inhalation is a recognized health issue that carries a risk of developing chronic health problems, particularly respiratory system diseases (RSDs). Aside from general airway irritation, WF exposure may drive direct cellular responses in the respiratory system which increase risk of RSD, but these are not well understood. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.04.004DOI Listing
April 2019
2 Reads

Learn to segment single cells with deep distance estimator and deep cell detector.

Comput Biol Med 2019 Apr 8;108:133-141. Epub 2019 Apr 8.

Department of Computational and System Biology, University of Pittsburgh, Pittsburgh, PA, 15260, USA; UPMC-Hillman Cancer Center, University of Pittsburgh, Pittsburgh, 15232, PA, USA. Electronic address:

Single cell segmentation is a critical and challenging step in cell imaging analysis. Traditional processing methods require time and labor to manually fine-tune parameters and lack parameter transferability between different situations. Recently, deep convolutional neural networks (CNN) treat segmentation as a pixel-wise classification problem and have become a general and efficient method for image segmentation. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.04.006DOI Listing
April 2019
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Salicylic acid alleviates glyphosate-induced oxidative stress in Hordeum vulgare L.

J Environ Manage 2019 Apr 17;241:226-234. Epub 2019 Apr 17.

GreenUPorto - Centro de Investigação Em Produção Agroalimentar Sustentável, BiologyDepartment, FacultyofSciences, University of Porto, Rua Campo Alegre S/n, 4169-007, Porto, Portugal; Plant Stress Lab, Biology Department, Faculty of Sciences, University of Porto, Rua Campo Alegre S/n, 4169-007, Porto, Portugal.

Glyphosate (GLY) is considered the most used herbicide in the world and has been associated with several environmental contamination risks. Despite being partially degraded by soil microorganisms, its residues can negatively affect the growth of valuable non-target plants. Thus, there is a need to find new strategies that minimize its impacts and enhance crop tolerance to GLY, allowing a more advantageous and safer, use of this herbicide. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03014797193049
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http://dx.doi.org/10.1016/j.jenvman.2019.04.035DOI Listing
April 2019
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Glucosidase activity in dental biofilms in adolescent patients with fixed orthodontic appliances - a putative marker for white spot lesions - a clinical exploratory trial.

Arch Oral Biol 2019 Apr 8;102:122-127. Epub 2019 Apr 8.

Department of Oral Biology, Faculty of Odontology, Malmö University, Malmö, Sweden.

Objectives: Approximately 25% of the adolescents in the Scandinavian population are treated with a fixed orthodontic appliance (FOA). Adverse effects such as enamel decalcification (white spot lesions - WSL), seem to affect over 30% of patients. WSL have only a limited ability to improve, thus seriously jeopardising the treatment outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039969183091
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http://dx.doi.org/10.1016/j.archoralbio.2019.04.003DOI Listing
April 2019
2 Reads

Synergism of open chromatin regions involved in regulating genes in Bombyx mori.

Insect Biochem Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

Biological Science Research Center, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing 400715, China. Electronic address:

The dynamic variability of transcription factors (TFs) and their binding sites makes it challenging to conduct genome-wide transcription regulation research. The silkworm Bombyx mori, which produces silk, is one of the most valuable model insects in the order Lepidoptera. The "opening" and "closing" of chromatin in different silk yield strains is associated with changes in silk production, making this insect a good model for studying the transcriptional regulation of genes. Read More

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http://dx.doi.org/10.1016/j.ibmb.2019.04.014DOI Listing
April 2019
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Variations in Core Packing of GP2 from Old World Mammarenaviruses in their Post-Fusion Conformations Affect Membrane-Fusion Efficiencies.

J Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel. Electronic address:

Lassa virus (LASV) is a notorious human pathogen in West Africa. Its class-I trimeric spike complex displays a distinct architecture, and its cell entry mechanism involves unique attributes not shared by other related viruses. We determined the crystal structure of the GP2 fusion glycoprotein from the spike complex of LASV (GP2) in its post-fusion conformation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00222836193020
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http://dx.doi.org/10.1016/j.jmb.2019.04.012DOI Listing
April 2019
1 Read

Sex allocation conflict and sexual selection throughout the lifespan of eusocial colonies.

Evolution 2019 Apr 20. Epub 2019 Apr 20.

Department of Ecology and Evolution, University of Lausanne, Biophore, 1015, Lausanne, Switzerland.

Models of sex allocation conflict are central to evolutionary biology but have mostly assumed static decisions, where resource allocation strategies are constant over colony lifespan. Here, we develop a model to study how the evolution of dynamic resource allocation strategies is affected by the queen-worker conflict in annual eusocial insects. We demonstrate that the time of dispersal of sexuals affects the sex allocation ratio through sexual selection on males. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/evo.13746
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http://dx.doi.org/10.1111/evo.13746DOI Listing
April 2019
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Bayesian inference of evolutionary histories under time-dependent substitution rates.

Mol Biol Evol 2019 Apr 19. Epub 2019 Apr 19.

Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven - University of Leuven, Leuven, Belgium.

Many factors complicate the estimation of time-scales for phylogenetic histories, requiring increasingly complex evolutionary models and inference procedures. The widespread application of molecular clock dating has led to the insight that evolutionary rate estimates may vary with the time frame of measurement. This is particularly well-established for rapidly evolving viruses that can accumulate sequence divergence over years or even months. Read More

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https://academic.oup.com/mbe/advance-article/doi/10.1093/mol
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http://dx.doi.org/10.1093/molbev/msz094DOI Listing
April 2019
3 Reads

The Role of Mutation Bias in Adaptive Evolution.

Trends Ecol Evol 2019 May;34(5):422-434

Department of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, Norrbyvägen 18D, SE-752 36 Uppsala, Sweden.

Mutational input is the ultimate source of genetic variation, but mutations are not thought to affect the direction of adaptive evolution. Recently, critics of standard evolutionary theory have questioned the random and non-directional nature of mutations, claiming that the mutational process can be adaptive in its own right. We discuss here mutation bias in adaptive evolution. Read More

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http://dx.doi.org/10.1016/j.tree.2019.01.015DOI Listing

Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

Transplant Immunology, Department of Pathology & Laboratory Medicine & Biesecker Center for Study of Pediatric Liver Diseases, Children's Hospital of Philadelphia, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Functions of the GCN5-related N-acetyltransferase (GNAT) family of histone/protein acetyltransferases (HATs) in Foxp3+ T-regulatory (Treg) cells are unexplored, despite the general importance of these enzymes in cell biology. We now show that two prototypical GNAT family members, GCN5 (general control nonrepressed-protein 5, lysine acetyltransferase (KAT)2a) and p300/CBP-associated factor (p300/CBP-associated factor (PCAF), Kat2b) contribute to Treg functions through partially distinct and partially overlapping mechanisms. Deletion of Gcn5 or PCAF did not affect Treg development or suppressive function in vitro, but did affect inducible Treg (iTreg) development, and in vivo, abrogated Treg-dependent allograft survival. Read More

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http://dx.doi.org/10.3390/cancers11040554DOI Listing

Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

Laboratory of Molecular and Cellular Cancer Biology, Azrieli Faculty of Medicine, Bar-Ilan University, 1311502 Safed, Israel.

SMURF2, an E3 ubiquitin ligase and suggested tumor suppressor, operates in normal cells to prevent genomic instability and carcinogenesis. However, the mechanisms underlying SMURF2 inactivation in human malignancies remain elusive, as is rarely found mutated or deleted in cancers. We hypothesized that SMURF2 might have a distinct molecular biodistribution in cancer versus normal cells and tissues. Read More

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https://www.mdpi.com/2072-6694/11/4/556
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http://dx.doi.org/10.3390/cancers11040556DOI Listing
April 2019
1 Read

Terrestrial organic matter increases zooplankton methylmercury accumulation in a brown-water boreal lake.

Sci Total Environ 2019 Mar 29;674:9-18. Epub 2019 Mar 29.

Department of Bioscience, University of Oslo, Blindernveien 31, 0371 Oslo, Norway. Electronic address:

Increases in terrestrial organic matter (tOM) transport from catchments to boreal lakes can affect methylmercury (MeHg) accumulation in aquatic biota both directly by increasing concentrations of aqueous MeHg, and indirectly through effects on MeHg bioavailability and on energy pathways in the lower food web. We carried out a detailed seasonal study of water chemistry, zooplankton diet, and MeHg accumulation in zooplankton in two lakes with contrasting tOM concentrations. Between-lake differences explained 51% of the variability in our water chemistry data, with no observed effect of season or sampling depth, contrary to our expectations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.446DOI Listing

Determinants of phthalate exposure and risk assessment in children from Poland.

Environ Int 2019 Apr 16;127:742-753. Epub 2019 Apr 16.

Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine (NIOM), Lodz, Poland.

Phthalates are a group of widely used chemicals and humans are exposed to them in their daily life. Some phthalates may affect the hormonal balance in both children and adults. The aim of this study was to assess the phthalate exposure and its determinants among children at age of 7 years from the Polish Mother and Child Cohort Study (REPRO_PL). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120193065
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http://dx.doi.org/10.1016/j.envint.2019.04.011DOI Listing
April 2019
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The circadian clock gene is required to control the timing of retinal neurogenesis and lamination of Müller glia in the mouse retina.

FASEB J 2019 Apr 19:fj201801832RR. Epub 2019 Apr 19.

Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

A single pool of multipotent retinal progenitor cells give rise to the diverse cell types within the mammalian retina. Such cellular diversity is due to precise control of various cellular processes like cell specification, proliferation, differentiation, and maturation. Circadian clock genes can control the expression of key regulators of cell cycle progression and therefore can synchronize the cell cycle state of a heterogeneous population of cells. Read More

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http://dx.doi.org/10.1096/fj.201801832RRDOI Listing
April 2019
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Specific amino acid substitutions in β strand S2 of FtsZ cause spiraling septation and impair assembly cooperativity in Streptomyces spp.

Mol Microbiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Biology, Lund University, 223 62, Lund, Sweden.

Bacterial cell division is orchestrated by the Z ring, which is formed by single-stranded treadmilling protofilaments of FtsZ. In Streptomyces, during sporulation, multiple Z rings are assembled and lead to formation of septa that divide a filamentous hyphal cell into tens of prespore compartments. We describe here mutant alleles of ftsZ in Streptomyces coelicolor and Streptomyces venezuelae that perturb cell division in such a way that constriction is initiated along irregular spiral-shaped paths rather than as regular septa perpendicular to the cell length axis. Read More

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http://dx.doi.org/10.1111/mmi.14262DOI Listing

The Brassicaceae-specific secreted peptides, STMPs, function in plant growth and pathogen defense.

J Integr Plant Biol 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai'an, Shandong 271018, China.

Low molecular weight secreted peptides have recently been shown to affect multiple aspects of plant growth, development, and defense responses. Here, we performed stepwise BLAST filtering to identify unannotated peptides from the Arabidopsis thaliana protein database and uncovered a novel secreted peptide family, secreted transmembrane peptides (STMPs). These low molecular weight peptides, which consist of an N-terminal signal peptide and a transmembrane domain, were primarily localized to extracellular compartments but were also detected in the endomembrane system of the secretory pathway, including the endoplasmic reticulum and Golgi. Read More

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http://dx.doi.org/10.1111/jipb.12817DOI Listing

The transcription factors ActR and SoxR differentially affect the phenazine tolerance of Agrobacterium tumefaciens.

Mol Microbiol 2019 Apr 19. Epub 2019 Apr 19.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

Bacteria in soils encounter redox-active compounds, such as phenazines, that can generate oxidative stress, but the mechanisms by which different species tolerate these compounds are not fully understood. Here, we identify two transcription factors, ActR and SoxR, that play contrasting yet complementary roles in the tolerance of the soil bacterium Agrobacterium tumefaciens to phenazines. We show that ActR promotes phenazine tolerance by proactively driving expression of a more energy-efficient terminal oxidase at the expense of a less-efficient alternative, which may affect the rate at which phenazines abstract electrons from the electron transport chain and thereby generate reactive oxygen species. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/mmi.14263
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http://dx.doi.org/10.1111/mmi.14263DOI Listing
April 2019
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Field Testing Integrated Interventions for Schistosomiasis Elimination in the People's Republic of China: Outcomes of a Multifactorial Cluster-Randomized Controlled Trial.

Front Immunol 2019 3;10:645. Epub 2019 Apr 3.

Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Despite significant progress, China faces the challenge of re-emerging schistosomiasis transmission in currently controlled areas due, in part, to the presence of a range of animal reservoirs, notably water buffalo and cattle, which can harbor infections. Environmental, ecological and social-demographic changes in China, shown to affect the distribution of oncomelanid snails, can also impact future schistosomiasis transmission. In light of their importance in the , lifecycle, vaccination has been proposed as a means to reduce the excretion of egg from cattle and buffalo, thereby interrupting transmission from these reservoir hosts to snails. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456715PMC
April 2019
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Transcriptome and Proteome Response of Tick Vector to Infection.

Front Physiol 2019 2;10:318. Epub 2019 Apr 2.

Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.

A system biology approach was used to gain insight into tick biology and interactions between vector and pathogen. is one of the main vectors of which has a massive impact on animal health. It is vital to obtain more information about this relationship, to better understand tick and pathogen biology, pathogen transmission dynamics, and new potential control approaches. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00318
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http://dx.doi.org/10.3389/fphys.2019.00318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454348PMC
April 2019
2 Reads

Abiotic and biotic factors controlling fine root biomass, carbon and nutrients in closed-canopy hybrid poplar stands on post-agricultural land.

Sci Rep 2019 Apr 18;9(1):6296. Epub 2019 Apr 18.

Fiducie de recherche sur la forêt des Cantons-de-l'Est/Eastern Townships Forest Research Trust, 1 rue Principale, Saint-Benoît-du-Lac, Qc, J0B 2M0, Canada.

Fine roots (diameter <2 mm) have a pivotal role in resource acquisition, symbiosis development, and for elemental cycling in forests. Various abiotic and biotic factors affect their biomass and nutrient content. Understanding the effect of these factors on root traits could improve biogeochemical modelling, nutrient management and ecosystem services provision in planted forests. Read More

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http://dx.doi.org/10.1038/s41598-019-42709-6DOI Listing

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.

Science 2019 Apr 18;364(6437):286-289. Epub 2019 Apr 18.

Innovative Genomics Institute, University of California Berkeley, Berkeley, CA 94704, USA.

CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct detection in vivo. We developed DISCOVER-Seq (discovery of in situ Cas off-targets and verification by sequencing), a universally applicable approach for unbiased off-target identification that leverages the recruitment of DNA repair factors in cells and organisms. Read More

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http://dx.doi.org/10.1126/science.aav9023DOI Listing

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase.

Proc Natl Acad Sci U S A 2019 Apr 18. Epub 2019 Apr 18.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921;

Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes Chikungunya fever. Nonstructural protein 2 (nsP2) exhibits the protease and RNA helicase activities that are required for viral RNA replication and transcription. Unlike for the C-terminal protease, the structure of the N-terminal RNA helicase (nsP2h) has not been determined. Read More

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http://dx.doi.org/10.1073/pnas.1900656116DOI Listing
April 2019
2 Reads

Rethinking sex determination of non-gonadal tissues.

Authors:
Arthur P Arnold

Curr Top Dev Biol 2019 12;134:289-315. Epub 2019 Feb 12.

Department of Integrative Biology & Physiology, Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, United States. Electronic address:

Evolution of genetic mechanisms of sex determination led to two processes causing sex differences in somatic phenotypes: gonadal differentiation and sex chromosome dosage inequality. In species with heteromorphic sex chromosomes, the sex of the individual is established at the time of formation of the zygote, leading to inherent sex differences in expression of sex chromosome genes beginning as soon as the embryonic transcriptome is activated. The inequality of sex chromosome gene expression causes sexual differentiation of the gonads and of non-gonadal tissues. Read More

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http://dx.doi.org/10.1016/bs.ctdb.2019.01.003DOI Listing
February 2019

Effect of stem cell transplantation on patients with ischemic heart failure: a systematic review and meta-analysis of randomized controlled trials.

Stem Cell Res Ther 2019 Apr 18;10(1):125. Epub 2019 Apr 18.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.

Stem cell transplantation (SCT) has become a promising way to treat ischemic heart failure (IHF). We performed a large-scale meta-analysis of randomized clinical trials to investigate the efficacy and safety of SCT in IHF patients. Randomized controlled trials (RCTs) involving stem cell transplantation for the treatment of IHF were identified by searching the PubMed, EMBASE, SpringerLink, Web of Science, and Cochrane Systematic Review databases as well as from reviews and the reference lists of relevant articles. Read More

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http://dx.doi.org/10.1186/s13287-019-1214-0DOI Listing