14,329 results match your criteria Biology of Reproduction[Journal]


Assisted Reproductive Technologies for Endangered Species Conservation: Developing sophisticated protocols with limited access to animals with unique reproductive mechanisms.

Authors:
Jason R Herrick

Biol Reprod 2019 Feb 16. Epub 2019 Feb 16.

Assisted reproductive technologies (ARTs) have been proposed as a means of overcoming the significant challenges of managing small, isolated populations of endangered species in zoos. However, efficient protocols for ARTs do not exist for most endangered species. This review will focus on research efforts to characterize unique reproductive mechanisms and develop species-specific ARTs. Read More

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http://dx.doi.org/10.1093/biolre/ioz025DOI Listing
February 2019
1 Read

Autoimmune Regulator (AIRE) is required in female mice for optimal embryonic development and implantation1.

Biol Reprod 2019 Feb 16. Epub 2019 Feb 16.

Dept. Pathobiology & Diagnostic Investigation, and.

Autoimmune Regulator (AIRE) regulates central immune tolerance by inducing expression of tissue-restricted antigens in thymic medullary epithelial cells, thereby ensuring elimination of autoreactive T cells. Aire mutations in humans and targeted Aire deletion in mice results in multi-organ autoimmune disease, known in humans as Autoimmune Polyglandular Syndrome Type 1 (APS-1). APS-1 is characterized by presence of adrenal insufficiency, chronic mucosal candidiasis, and/or hypoparathyroidism. Read More

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http://dx.doi.org/10.1093/biolre/ioz023DOI Listing
February 2019

MicroRNA-30a-3p regulates epithelial-mesenchymal transition to affect embryo implantation by targeting Snai2.

Biol Reprod 2019 Feb 11. Epub 2019 Feb 11.

Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, P. R. China.

Objective: To study the potential role of miR-30a-3p in embryo implantation and explore underlying mechanisms.

Methods: We first established normal pregnancy, pseudopregnancy, delayed implantation, and artificial decidualization mouse models. Next, we detected miR-30a-3p expression profiles of these models with real-time reverse transcription PCR(qRT-PCR), then predicted potential target genes through a dual-luciferase assay. Read More

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http://dx.doi.org/10.1093/biolre/ioz022DOI Listing
February 2019

A high-throughput method for unbiased quantitation and categorisation of nuclear morphology.

Biol Reprod 2019 Feb 11. Epub 2019 Feb 11.

School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK.

The physical arrangement of chromatin in the nucleus is cell type and species specific; a fact particularly evident in sperm, in which most of the cytoplasm has been lost. Analysis of the characteristic falciform ("hook shaped") sperm in mice is important in studies of sperm development, hybrid sterility, infertility and toxicology. However, quantification of sperm shape differences typically relies on subjective manual assessment, rendering comparisons within and between samples difficult. Read More

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http://dx.doi.org/10.1093/biolre/ioz013DOI Listing
February 2019

Luteinizing hormone signaling is involved in synchronization of Leydig cell clock and is crucial for rhythm robustness of testosterone production.

Biol Reprod 2019 Feb 4. Epub 2019 Feb 4.

Laboratory for Chronobiology and Aging; Laboratory for Reproductive Endocrinology and Signaling, Faculty of Sciences University of Novi Sad, Novi Sad, Serbia.

In mammals, circadian clock regulates concentration of many reproductive hormones including testosterone. Previously, we characterized pattern of circadian transcription of core clock genes in testosterone-producing Leydig cells. Here the potential role of luteinizing hormone receptor (LHR)-cAMP signaling in synchronization of Leydig cell's circadian clock and rhythmic testosterone production were examined. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioz020DOI Listing
February 2019
2 Reads
3.318 Impact Factor

LncRNAs and paraspeckles predict cell fate in early mouse embryo.

Biol Reprod 2019 Feb 4. Epub 2019 Feb 4.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.

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http://dx.doi.org/10.1093/biolre/ioz021DOI Listing
February 2019

microRNAs in endometriosis: Biological function and emerging biomarker candidates.

Biol Reprod 2019 Feb 4. Epub 2019 Feb 4.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06520, USA.

MicroRNAs (miRNAs), a class of small non-coding RNA molecules, have been recognized as key post-transcriptional regulators associated with a multitude of human diseases. Global expression profiling studies have uncovered hundreds of miRNAs that are dysregulated in several diseases, and yielded many candidate biomarkers. This review will focus on miRNAs in endometriosis, a common chronic disease affecting nearly 10% of reproductive-aged women, which can cause pelvic pain, infertility, and a myriad of other symptoms. Read More

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http://dx.doi.org/10.1093/biolre/ioz014DOI Listing
February 2019
2 Reads

Clinical application of embryo aneuploidy testing by NGS.

Biol Reprod 2019 Feb 4. Epub 2019 Feb 4.

Igenomix Foundation/Instituto de Investigación Sanitaria Hospital Clínico (INCLIVA), Valencia, Spain.

We review here the evolution in the field of embryo aneuploidy testing over the last 20 years, from the analysis of a subset of chromosomes by fluorescence in situ hybridisation (FISH) to the transition toward a more comprehensive analysis of all 24 chromosomes. This current comprehensive aneuploidy testing most commonly employs next-generation sequencing (NGS). We present our experience in over 130,000 embryo biopsies using this technology. Read More

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http://dx.doi.org/10.1093/biolre/ioz019DOI Listing
February 2019
1 Read
3.318 Impact Factor

Membrane raft-mediated regulation of glucose signaling pathway leading to acrosome reaction in chicken sperm.

Biol Reprod 2019 Feb 4. Epub 2019 Feb 4.

Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572 JAPAN.

Despite knowledge that glucose metabolism is essential for the regulation of signaling cascades in the sperm that are pre-assembled into specific areas and function at multistage for fertilization, the physiological roles of glucose in avian sperm are poorly understood. Accumulated results of studies conducted in our laboratory and others indicate that sperm possess membrane microdomains, or membrane rafts, which play important roles in several processes, including the induction of acrosome reaction (AR). When characterizing proteomes associated with chicken sperm rafts, we observed marked enrichment of glucose transporter 3 (GLUT3). Read More

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http://dx.doi.org/10.1093/biolre/ioz015DOI Listing
February 2019

Analysis of metabolic flux in felid spermatozoa using metabolomics and 13C-based fluxomics.

Biol Reprod 2019 Jan 30. Epub 2019 Jan 30.

Department of Animal & Avian Sciences, University of Maryland, College Park, MD 20742, USA.

Spermatozoa from three feline species-domestic cats (Felis catus), cheetahs (Acinonyx jubatus), and clouded leopards (Neofelis nebulosa)-were analyzed using metabolomic profiling and 13C-based fluxomics to address questions raised regarding their energy metabolism. Metabolic profiles and utilization of 13C-labeled energy substrates were detected and quantified using gas chromatography-mass spectrometry (GC-MS). Spermatozoa were collected by electroejaculation and incubated in media supplemented with 1. Read More

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http://dx.doi.org/10.1093/biolre/ioz010DOI Listing
January 2019

Investigation into the presence and functional significance of proinsulin C-peptide in the female germline.

Biol Reprod 2019 Jan 30. Epub 2019 Jan 30.

Priority Research Centre for Reproductive Science, Discipline of Biological Sciences. The Hunter Medical Research Institute, New Lambton Heights and the University of Newcastle, Callaghan, NSW 2308, Australia.

Diabetes is associated with poor oocyte quality and the dysregulation of ovarian function and is thus a leading contributor to the increasing prevalence of female reproductive pathologies. Accordingly, it is well-established that insulin fulfils a key role in the regulation of several facets of female reproduction. What remains less certain is whether proinsulin C-peptide, which has recently been implicated in cellular signaling cascades, holds any functional role in the female germline. Read More

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http://dx.doi.org/10.1093/biolre/ioz008DOI Listing
January 2019

Distinct dormancy progression depending on embryonic regions during mouse embryonic diapause.

Biol Reprod 2019 Feb 1. Epub 2019 Feb 1.

Division of Embryology, National Institute for Basic Biology, Okazaki, Japan.

Many mammalian species undergo embryonic diapause and suspend development at the blastocyst stage before implantation, which is also known as delayed implantation. We studied the process of how mouse embryos enter a dormancy status at a cellular level. Immunofluorescent analysis of differentiation markers for epiblast, primitive endoderm and trophectoderm suggested that cell differentiation status was maintained during 7days in diapause. Read More

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http://dx.doi.org/10.1093/biolre/ioz017DOI Listing
February 2019

Endometriosis biomarkers: Will co-development in academia-industry partnerships result in new and robust noninvasive diagnostic tests?

Biol Reprod 2019 Feb 1. Epub 2019 Feb 1.

Department of Development and Regeneration, Biomedical Sciences Group, KU Leuven (University of Leuven), Belgium.

Endometriosis is an important gynecological disease, affecting 10% of reproductive age women, and associated with pain, infertility, reduced quality of life and high health economic cost. Except for ultrasound detection of ovarian endometriotic cysts, the gold standard for diagnosis is laparoscopy, leading to diagnostic delays of 5-10 years. Accurate noninvasive biomarkers are needed, especially for symptomatic women with a normal gynecological ultrasound, to triage them towards medical or surgical treatment and to monitor their treatment outcome. Read More

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http://dx.doi.org/10.1093/biolre/ioz016DOI Listing
February 2019
2 Reads

In Memoriam of Professor John A. McCracken, Ph.D., 1935-2019.

Authors:
Fuller W Bazer

Biol Reprod 2019 Feb 1. Epub 2019 Feb 1.

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http://dx.doi.org/10.1093/biolre/ioz018DOI Listing
February 2019

A story of birth and death: mRNA translation and clearance at the onset of Maternal-to-Zygotic transition in mammals.

Biol Reprod 2019 Jan 31. Epub 2019 Jan 31.

MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

In mammals, maternal-to-zygotic transition (MZT), or oocyte-to-embryo transition, begins with oocyte meiotic resumption due to the sequential translational activation and destabilization of dormant maternal transcripts stored in the ooplasm. It then continues with the elimination of maternal transcripts during oocyte maturation and fertilization and ends with the full transcriptional activation of the zygotic genome during embryonic development. A hallmark of MZT in mammals is its reliance on translation and the utilization of stored RNAs and proteins, rather than de novo transcription of genes, to sustain meiotic maturation and early development. Read More

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http://dx.doi.org/10.1093/biolre/ioz012DOI Listing
January 2019

Intra-follicular growth differentiation factor 9: Bone morphogenetic 15 ratio determines litter size in mammals.

Biol Reprod 2019 Jan 29. Epub 2019 Jan 29.

School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand.

We previously showed that rat, pig, sheep and red deer oocytes express species-specific ratios of GDF9: BMP15 mRNA (3.7, 0.5, 1. Read More

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http://dx.doi.org/10.1093/biolre/ioz011DOI Listing
January 2019

Lean maternal hyperglycemia alters offspring lipid metabolism and susceptibility to Diet-Induced obesity in mice.

Biol Reprod 2019 Jan 29. Epub 2019 Jan 29.

Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, MO, USA.

We previously developed a model of gestational diabetes mellitus (GDM) in which dams exhibit glucose intolerance, insulin resistance and reduced insulin response to glucose challenge only during pregnancy, without accompanying obesity. Here, we aimed to determine how lean gestational glucose intolerance affects offspring risk of metabolic dysfunction. One cohort of offspring was sacrificed at 19 weeks, and one at 31 weeks, with half of the second cohort placed on a high fat high sucrose diet (HFHS) at 23 weeks. Read More

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http://dx.doi.org/10.1093/biolre/ioz009DOI Listing
January 2019
1 Read

Next milestone in understanding early life-blastoids mimic embryogenesis in vitro.

Biol Reprod 2019 Jan;100(1):11-12

German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), 10589 Berlin, Germany.

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http://dx.doi.org/10.1093/biolre/ioy182DOI Listing
January 2019
1 Read

Contributions of Ryuzo Yanagimachi to the field of reproductive biology.

Biol Reprod 2019 Jan;100(1):1-7

Institute for Biogenesis Research, Department of Anatomy, Biochemistry & Physiology, Department of Obstetrics, Gynecology and Women's Health, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.

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http://dx.doi.org/10.1093/biolre/ioy191DOI Listing
January 2019
1 Read

An interview with Dr Richard Behringer.

Authors:
T Rajendra Kumar

Biol Reprod 2019 Jan;100(1):8-10

Department of Obstetrics and Gynecology, Division of Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1093/biolre/ioy189DOI Listing
January 2019
1 Read

Synergistic effects of estradiol and 11-ketotestosterone on vitellogenin physiology in the shortfinned eel (Anguilla australis).

Biol Reprod 2019 Jan 17. Epub 2019 Jan 17.

Department of Zoology, University of Otago, PO Box 56, Dunedin 9054, New Zealand.

Estradiol-17β (E2) and 11-ketotestosterone (11KT) have been implicated in vitellogenesis and in regulating expression of the follicle-stimulating hormone receptor (fshr), respectively. To override the captivity-induced reproductive block in shortfinned eel, Anguilla australis, we hypothesised that in combination, 11KT and E2 would stimulate ovarian uptake of vitellogenin (Vtg). Early pubertal eels received hormone implants containing varying concentrations of E2 (0, 0. Read More

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http://dx.doi.org/10.1093/biolre/ioz007DOI Listing
January 2019
1 Read

Reducing time to pregnancy and facilitating the birth of healthy children through functional analysis of embryo physiology.

Biol Reprod 2019 Jan 16. Epub 2019 Jan 16.

School of BioSciences, University of Melbourne, VIC 3010, Australia.

An ever-increasing number of couples rely on assisted reproductive technologies (ART) in order to conceive a child. Although advances in embryo culture have led to increases in the success rates of clinical ART, it often takes more than one treatment cycle to conceive a child. Ensuring patients conceive as soon as possible with a healthy embryo is a priority for reproductive medicine. Read More

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http://dx.doi.org/10.1093/biolre/ioz005DOI Listing
January 2019
3 Reads

The orientation of a decellularized uterine scaffold determines the tissue topology and architecture of the regenerated uterus in rats.

Biol Reprod 2019 Jan 14. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo.

A decellularized uterine scaffold (DUS) prepared from rats permits recellularization and regeneration of uterine tissues when placed onto a partially excised uterus and supports pregnancy in a fashion comparable to the intact uterus. The underlying extracellular matrix (ECM) together with an acellular, perfusable vascular architecture preserved in DUS is thought to be responsible for appropriate regeneration of the uterus. To investigate this concept, we examined the effect of the orientation of the DUS-preserving ECM and the vascular architecture on uterine regeneration through placement of a DUS onto a partially defective uterine area in the reversed orientation such that the luminal face of the DUS was outside and the serosal face was inside. Read More

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http://dx.doi.org/10.1093/biolre/ioz004DOI Listing
January 2019
2 Reads

RNF216 is essential for spermatogenesis and male fertility.

Biol Reprod 2019 Jan 15. Epub 2019 Jan 15.

Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA.

Ring finger protein 216 (RNF216) belongs to the RING family of E3 ubiquitin ligases that are involved in cellular protein degradation. Mutations in human Rnf216 gene have been identified in Gordon Holmes syndrome, which is defined by ataxia, dementia and hypogonadotropism. However, the gene function of Rnf216 in mammalian species remains unknown. Read More

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http://dx.doi.org/10.1093/biolre/ioz006DOI Listing
January 2019
2 Reads
3.318 Impact Factor

The Wilms tumor gene (WT1) (+ / - KTS) isoforms regulate steroidogenesis by modulating the PI3K/AKT and ERK1/2 pathways in bovine granulosa cells.

Biol Reprod 2019 Jan 14. Epub 2019 Jan 14.

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.

The Wilms' tumor (WT) gene WT1 encodes the splicing variants WT1(+ KTS) and WT1(- KTS). Recent data suggest that WT1 plays an important role in the development of mice follicles. However, the mechanism through which WT1 influences ovarian steroidogenesis remains unknown. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioz003DOI Listing
January 2019
7 Reads

ATRX is downstream of PKA in the meiotic cell cycle signaling cascade in Xenopus oocytes and is dynamically regulated in response to DNA damage.

Biol Reprod 2019 Jan 14. Epub 2019 Jan 14.

UCD School of Bimolecular and Biomedical Science, University College Dublin, Dublin, Ireland.

ATRX is a chromatin remodeling protein that belongs to the SWI2/SNF2 family of helicase/ATPases. During meiosis ATRX is necessary for heterochromatin formation and maintenance of chromosome stability in order to ensure proper assembly of the metaphase II spindle. Previously we established ATRX as a novel progesterone regulated protein during bovine meiotic maturation, in addition to being dynamically regulated in response to DNA damage in oocytes. Read More

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http://dx.doi.org/10.1093/biolre/ioz001DOI Listing
January 2019
1 Read

Effects of macrophage depletion on characteristics of cervix remodeling and pregnancy in CD11b-dtr mice.

Biol Reprod 2019 Jan 9. Epub 2019 Jan 9.

MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, Scotland EH16 4TJ United Kingdom.

To test the hypothesis that macrophages are essential for remodeling the cervix in preparation for birth, pregnant homozygous CD11b-dtr mice were injected with diphtheria toxin (DT) on days 14 and 16 postbreeding. On day 15 postbreeding, macrophages (F4/80 + ) were depleted in cervix, kidney, but not liver, ovary, or other non-reproductive tissues in DT- compared to saline-treated dtr mice or wildtype controls given DT or saline. Within 24h of DT-treatment, the density of cell nuclei and macrophages declined in cervix stroma in dtr mice versus controls, but birefringence of collagen, as an indication of extracellular cross-linked structure, remained unchanged. Read More

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http://dx.doi.org/10.1093/biolre/ioz002DOI Listing
January 2019
2 Reads

Bone marrow-derived endothelial progenitor cells contribute to vasculogenesis of pregnant mouse uterus.

Biol Reprod 2019 Jan 2. Epub 2019 Jan 2.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.

Angiogenesis is essential for cyclic endometrial growth, implantation and pregnancy maintenance. Vasculogenesis, the formation of new blood vessels by bone marrow (BM)-derived endothelial progenitor cells (EPCs), has been shown to contribute to endometrial vasculature. However, it is unknown whether vasculogenesis occurs in neovascularization of the decidua during pregnancy. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy265DOI Listing
January 2019
2 Reads

Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine model.

Biol Reprod 2018 Dec 28. Epub 2018 Dec 28.

Stem Cell Therapy Unit, Jesús Usón Minimally Invasive Surgery Centre (JUMISC), Cáceres, Spain.

Advanced age is a risk factor undermining women´s fertility. Hence, the optimization of assisted reproduction techniques is an interdisciplinary challenge that requires the improvement of in vitro culture systems. Here, we hypothesize that supplementation of embryo culture medium with extracellular vesicles from endometrial-derived mesenchymal stem cells (EV-endMSCs) may have a positive impact on the embryo competence of aged oocytes. Read More

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http://dx.doi.org/10.1093/biolre/ioy263DOI Listing
December 2018
3 Reads
3.318 Impact Factor

Maternal high-fat diet alters angiotensin ii receptors and causes changes in fetal and neonatal rats.

Biol Reprod 2018 Dec 28. Epub 2018 Dec 28.

Department of Pharmacology, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China.

Maternal high-fat diet (HFD) during pregnancy is linked to cardiovascular diseases in postnatal life. The current study tested the hypothesis that maternal HFD causes myocardial changes through angiotensin II receptor (AGTR) expression modulation in fetal and neonatal rat hearts. The control group of pregnant rats were fed a normal diet and the treatment group of pregnant rats was on a HFD (60% kcal fat). Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy262DOI Listing
December 2018
2 Reads

Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth and adverse neonatal outcomes.

Biol Reprod 2018 Dec 28. Epub 2018 Dec 28.

Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.

Preterm labor is a syndrome of multiple pathological processes that commonly leads to preterm birth, the leading cause of perinatal morbidity and mortality worldwide. Sterile intra-amniotic inflammation is commonly observed in patients with preterm labor. However, the mechanisms that lead to sterile intra-amniotic inflammation are poorly understood and there is no treatment for this clinical condition. Read More

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http://dx.doi.org/10.1093/biolre/ioy264DOI Listing
December 2018
3 Reads

Inflammation-Induced Intra-Amniotic inflammation induces preterm birth by Activating the NLRP3 inflammasome.

Biol Reprod 2018 Dec 24. Epub 2018 Dec 24.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA.

Intra-amniotic inflammation/infection is strongly associated with spontaneous preterm labor and birth, the leading cause of perinatal mortality and morbidity worldwide. Previous studies have suggested a role for the NLRP3 (NLR family pyrin domain-containing protein 3) inflammasome in the mechanisms that lead to preterm labor and birth. However, a causal link between the NLRP3 inflammasome and preterm labor/birth induced by intra-amniotic inflammation has not been established. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy261DOI Listing
December 2018
4 Reads
3.318 Impact Factor

An interview with Dr Patricia A. Martin-DeLeon.

Authors:
Romana A Nowak

Biol Reprod 2018 Nov;99(5):899-902

Department of Animal Sciences, University of Illinois, Urbana-Champaign, Illinois, USA.

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http://dx.doi.org/10.1093/biolre/ioy103DOI Listing
November 2018
1 Read

Chemotherapeutic agent doxorubicin alters uterine gene expression in response to estrogen in ovariectomized CD-1 adult mice.

Biol Reprod 2018 Dec 17. Epub 2018 Dec 17.

Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.

Chemotherapy can potentially impair fertility in premenopausal cancer patients. Female fertility preservation has been mainly focused on the ovarian aspects and benefited greatly from assisted reproductive technologies, such as in vitro fertilization (IVF). The rate-limiting step for the success of IVF is embryo implantation in the uterus. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy259DOI Listing
December 2018
14 Reads

Disruption of Usp26 gene causes male subfertility associated with spermatogenesis defects in mice.

Biol Reprod 2018 Dec 18. Epub 2018 Dec 18.

Research Center of Reproductive Medicine, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.

Ubiquitin-specific protease 26 (USP26) is an X-linked gene exclusively expressed in the testis and codes for the USP26, a peptidase enzyme that belongs to the deubiquitinating enzyme (DUB) family. Recent studies have indicated that mutations in USP26 affect spermatogenesis and are associated with male infertility in humans and mice. However, the exact role of USP26 in spermatogenesis and how it affects male reproduction remains unknown. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy258DOI Listing
December 2018
11 Reads

Heterosis extends the reproductive ability in aged female mice.

Biol Reprod 2018 Dec 18. Epub 2018 Dec 18.

Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan.

Heterosis is the beneficial effect of genetical heterozygosity in animals and plants. Although heterosis induces changes in the cells and individual abilities, few reports have described the effect of heterosis on the female reproductive ability during aging. In the present study, we investigated the reproductive capability of genetically heterozygous (HET) mice established by the four-way crossing of C57BL/6N, BALB/c, C3H/He, and DBA/2. Read More

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http://dx.doi.org/10.1093/biolre/ioy260DOI Listing
December 2018
2 Reads

In vitro breeding: application of embryonic stem cells to animal production.

Biol Reprod 2018 Dec 14. Epub 2018 Dec 14.

Department of Animal Science, University of California, Davis, CA.

Embryonic stem cells (ESCs) are derived from the inner cell mass of preimplantation blastocysts. For decades, attempts to efficiently derive ESCs in animal livestock species have been unsuccessful, but this goal has recently been achieved in cattle. Together with the recent reconstitution of the germ cell differentiation processes from ESCs in mice, these achievements open new avenues for the development of promising technologies oriented toward improving health, animal production and the environment. Read More

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http://dx.doi.org/10.1093/biolre/ioy256DOI Listing
December 2018
2 Reads

Production of donor-derived offspring by allogeneic transplantation of spermatogonia in Chinese rosy bitterling.

Biol Reprod 2018 Nov 15. Epub 2018 Nov 15.

Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Tokyo, Japan.

Many bitterling species are facing extinction because of habitat destruction. Since cryopreservation of fish eggs is still not available to date due to their large size and high yolk content, long-term and stable storage of bitterling genetic resources is currently not possible. We recently discovered that cryopreservation of early-stage germ cells is possible in several fish species and that functional gametes derived from the frozen materials can be produced through their transplantation to embryonic recipients. Read More

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http://dx.doi.org/10.1093/biolre/ioy236DOI Listing
November 2018
1 Read

Uterine microbiome-low biomass and high expectations.

Biol Reprod 2018 Dec 13. Epub 2018 Dec 13.

Igenomix Foundation, Instituto de Investigación Sanitaria Hospital Clínico (INCLIVA), Valencia, Spain.

The existence of different bacterial communities throughout the female reproductive tract has challenged the traditional view of human fetal development as a sterile event. There is still no consensus on what physiological microbiota exists in the upper reproductive tract of the vast majority of women who are not in periods of infection or pregnancy, and the role of bacteria that colonize the upper reproductive tract in uterine diseases or pregnancy outcomes is not well established. Despite published studies and advances in uterine microbiome sequencing, some study aspects-such as study design, sampling method, DNA extraction, sequencing methods, downstream analysis, and assignment of taxa-have not yet been improved and standardized. Read More

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http://dx.doi.org/10.1093/biolre/ioy257DOI Listing
December 2018
1 Read

DNA demethylation facilitates the specific transcription of the mouse X-linked Tsga8 gene in round spermatids.

Biol Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Genetics and Division of Human Morbid Genomics, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan Province, China.

Some X-linked genes necessary for spermiogenesis are specifically activated in the post-meiotic germ cells. However, the regulatory mechanism about this activation is not clearly understood. Here, we examined the potential mechanism controlling the transcriptional activation of the mouse testis specific gene A8 (Tsga8) gene in round spermatids. Read More

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http://dx.doi.org/10.1093/biolre/ioy255DOI Listing
December 2018
3 Reads

Inhibition of SCF complexes during bovine oocyte maturation and preimplantation development leads to delayed development of embryos.

Biol Reprod 2018 Dec 7. Epub 2018 Dec 7.

Laboratory of Developmental Biology, Institute of Animal Physiology and Genetics Academy of Science of Czech Republic, v.v.i., Libechov, Czech Republic.

The mechanism of maternal protein degradation during preimplantation development has not been clarified yet. It is thought that a lot of maternal proteins are degraded by ubiquitin-proteasome system. In this study, we focused on the role of the SCF (Skp1-Cullin-F-box) complexes during early bovine embryogenesis. Read More

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http://dx.doi.org/10.1093/biolre/ioy254DOI Listing
December 2018
1 Read

Expression profiles and characteristics of human lncRNA in normal and asthenozoospermia sperm.

Biol Reprod 2018 Dec 4. Epub 2018 Dec 4.

Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China.

Increasing studies have shown that specific mRNAs and miRNAs expressed in mature sperm may be related to sperm motility. However, the expression profiles and roles of lncRNAs in sperm remain unknown. In the present study, numerous lncRNAs were identified in human sperm, and some lncRNAs were expressed exclusively in sperm and testis. Read More

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http://dx.doi.org/10.1093/biolre/ioy253DOI Listing
December 2018
6 Reads

Recombinant adiponectin alleviates abortion in mice by regulating Th17/Treg imbalance via p38MAPK-STAT5 pathway.

Biol Reprod 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, the First affiliated hospital, Chongqing Medical University, Chongqing, China.

Recurrent spontaneous abortion (RSA) is associated with abnormal maternal tolerance to the semi-allogenic fetus, wherein the Th17/Treg axis plays a crucial role. Adiponectin (APN) is an adipocytokine that is shown to be a novel negative T-cell regulator and induce immune tolerance. The CBA/J × DBA/2 mating was used as an abortion-prone model to investigate whether the addition of recombinant adiponectin (rAPN) improves the pregnancy outcome. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy251DOI Listing
November 2018
13 Reads

Knockdown of long non-coding RNA CCDC144NL-AS1 attenuates migration and invasion phenotypes in endometrial stromal cells from endometriosis.

Biol Reprod 2018 Nov 28. Epub 2018 Nov 28.

Center of Gynecologic Oncology, Peking University People's Hospital, Beijing, China.

Endometriosis (EM) is a mysterious and complicated disease that has been found to be multifactorial. Recent studies demonstrated that long noncoding RNAs (lncRNAs) play an important role in the pathogenesis of EM. However, the functional and biological mechanisms of lncRNAs in EM remain unknown. Read More

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http://dx.doi.org/10.1093/biolre/ioy252DOI Listing
November 2018
3 Reads
3.318 Impact Factor

Calcium signaling and expression of voltage-gated calcium channels in the mouse ovary throughout the estrous cycle.

Biol Reprod 2018 Nov 28. Epub 2018 Nov 28.

Departamento Neurociencia Cognitiva.

The estrous cycle is an iterative change in the anatomy, endocrinology, physiology, and behavior to provide maximum fecundity. Ovarian steroid production involves gonadotrophin-induced [Ca2+]i raises due in part to voltage-gated Ca2+ channels (VGCC) whose identity and tissue distribution in situ is largely unknown. Using fluorescence Ca2+ imaging and confocal microscopy, we recorded both spontaneous and depolarization induced Ca2+ signals in living mouse ovarian slices. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy250DOI Listing
November 2018
17 Reads

Prostacyclin synthesis and prostacyclin receptor expression in the porcine corpus luteum: evidence for a luteotropic role in vitro.

Biol Reprod 2019 Jan;100(1):162-174

Department of Hormonal Action Mechanisms, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland.

The prostacyclin (prostaglandin I2) signaling system is an essential regulator of vascular homeostasis. Since the corpus luteum is a highly vascularized gland, prostacyclin seems to be crucial for luteal development and function. Although progress has been made in understanding the luteotropic action of prostacyclin in mammals, its role in the porcine corpus luteum remains to be determined. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy178DOI Listing
January 2019
6 Reads

Novel Roles of mTOR Signaling in Regulating Fetal Growth.

Biol Reprod 2018 Nov 21. Epub 2018 Nov 21.

Department of Obstetrics and Gynecology, Division of Reproductive Sciences, University of Colorado | Anschutz Medical Campus, Aurora, USA.

Mechanistic target of rapamycin (mTOR) signaling functions as a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. mTOR is therefore critical for the growth of most fetal organs and global mTOR deletion is embryonic lethal. This review discusses emerging evidence suggesting that mTOR signaling also has a role as a critical hub in the overall, homeostatic control of fetal growth, adjusting the fetal growth trajectory according to the ability of the maternal supply line to support fetal growth. Read More

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http://dx.doi.org/10.1093/biolre/ioy249DOI Listing
November 2018
3 Reads

Valosin-containing protein is associated with maintenance of meiotic arrest in mouse oocytes.

Biol Reprod 2018 Nov 21. Epub 2018 Nov 21.

College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R. China.

Valosin-containing protein (VCP) is a member of the highly conserved AAA (ATPase associated with a variety of cellular activities) superfamily. A previous study has shown that targeted deletion of Vcp in mice results in early embryonic lethality. The aim of the present study was to analyze the expression and localization of VCP and its function in meiotic arrest of mouse oocytes. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioy244DOI Listing
November 2018
9 Reads

Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans.

Biol Reprod 2018 Nov 24. Epub 2018 Nov 24.

Colorado Center for Reproductive Medicine, Lone Tree, Colorado, USA.

The objective of this work was to determine the role of mitochondria in the loss of oocyte quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number and function are reduced in eggs from aged mice after both in vivo and in vitro maturation. Higher incidences of spindle abnormalities were observed in old eggs. Read More

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http://dx.doi.org/10.1093/biolre/ioy248DOI Listing
November 2018
2 Reads

Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency.

Biol Reprod 2018 Nov 18. Epub 2018 Nov 18.

Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China.

Mechanism underlying premature ovarian insufficiency remains incompletely understood. Here we report that mice with Per1m/m; Per2m/m double mutations display a decrease in female fertility starting approximately at 20-week-old, with significantly less pups born from 32-week-old onwards. Histological analysis revealed that a significant reduction of ovarian follicles was observed in the Per1/Per2 mutants compared with the littermate controls examined at 26- and 52-week-old while the difference was not statistically significant between the two groups at 3- and 8-week-old. Read More

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http://dx.doi.org/10.1093/biolre/ioy245DOI Listing
November 2018
11 Reads
3.320 Impact Factor