1,679,506 results match your criteria Biology Bulletin[Journal]


Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam.

Gut Liver 2019 Apr 23. Epub 2019 Apr 23.

Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Oita, Japan.

Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug in Vietnam. We searched the PubMed, EMBASE, Vietnamese National Knowledge Infrastructure, and Vietnamese Biomedical databases from January 2000 to December 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5009/gnl18137DOI Listing
April 2019
1 Read

Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

St. Vincent's Institute of Medical Research.

Mutations in subunits of the cilia-specific cytoplasmic Dynein-2 (CD2) complex cause short-rib thoracic dystrophy syndromes (SRTDs), characterized by impaired bone growth and life-threatening perinatal respiratory complications. Different SRTD mutations result in varying disease severities. It remains unresolved whether this reflects the extent of retained hypomorphic protein functions or relative importance of the affected subunits for the activity of the CD2 holoenzyme. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddz083DOI Listing

Targeted Knock-In Mice with a Human Mutation in GRTH/DDX25 Reveals the Essential Role of Phosphorylated GRTH in Spermatid Development during Spermatogenesis.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Section on Molecular Endocrinology, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) is a testis specific member of the DEAD-box family of RNA helicases expressed in meiotic and haploid germ cells which plays an essential role in spermatogenesis. There are two species of GRTH the 56 kDa non-phospho and 61 kDa phospho forms. Our early studies revealed a missense mutation (R242H) of GRTH in azoospermic men that when expressed in COS1-cells lack the phospho-form of GRTH. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
Publisher Site
http://dx.doi.org/10.1093/hmg/ddz079DOI Listing

Postnatal Development of Mice with Combined Genetic Depletions of Lamin A/C, Emerin and Lamina-associated Polypeptide 1.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine.

Mutations in LMNA encoding lamin A/C and EMD encoding emerin cause cardiomyopathy and muscular dystrophy. Lmna null mice develop these disorders and have a lifespan of 7-8 weeks. Emd null mice show no overt pathology and have normal skeletal muscle but with regeneration defects. Read More

View Article

Download full-text PDF

Source
http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
Publisher Site
http://dx.doi.org/10.1093/hmg/ddz082DOI Listing
April 2019
1 Read

Synthesis and immunological studies of β-1,2-mannan-peptide conjugates as antifungal vaccines.

Eur J Med Chem 2019 Apr 5;173:250-260. Epub 2019 Apr 5.

Department of Chemistry, University of Florida, 214 Leigh Hall, Gainesville, FL, 32611, USA. Electronic address:

Fungal cell surface carbohydrates and proteins are useful antigens for the development of antifungal vaccines. In this study, glycopeptides consisting of the β-1,2-mannan and N-terminal peptide epitopes of Candida albicans (C. albicans) cell wall phosphomannan complex and Als1p (rAls1p-N) protein, respectively, were synthesized and covalently conjugated with keyhole limpet hemocyanin (KLH) and human serum albumin (HSA) through homobifunctional disuccinimidyl glutarate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.04.001DOI Listing

Design, synthesis and biological evaluation of novel neuchromenin analogues as potential antifungal agents.

Eur J Med Chem 2019 Apr 14;173:228-239. Epub 2019 Apr 14.

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi Province, China. Electronic address:

In continuation of our program to discover new potential antifungal agents, thirty-two neuchromenin analogues were synthesized and characterized by the spectroscopic analysis. By using the mycelium growth rate method, the target compounds were evaluated systematically for antifungal activities in vitro against six plant pathogenic fungi, and structure-activity relationships (SAR) were derived. Compounds 6b-c, and 6l showed obvious inhibition activity on each of the fungi at 50 μg/mL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.04.029DOI Listing

Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.

Eur J Med Chem 2019 Apr 6;173:213-227. Epub 2019 Apr 6.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an, 710069, China. Electronic address:

TMCA (3,4,5-trimethoxycinnamic acid) ester and amide are privileged structural scaffolds in drug discovery which are widely distributed in natural products and consequently produced diverse therapeutically relevant pharmacological functions. Owing to the potential of TMCA ester and amide analogues as therapeutic agents, researches on chemical syntheses and modifications have been carried out to drug-like candidates with broad range of medicinal properties such as antitumor, antiviral, CNS (central nervous system) agents, antimicrobial, anti-inflammatory and hematologic agents for a long time. At the same time, SAR (structure-activity relationship) studies have draw greater attention among medicinal chemists, and many of the lead compounds were derived for various disease targets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.04.009DOI Listing

A selectivity study of benzenesulfonamide derivatives on human carbonic anhydrase II/IX by 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation.

Comput Biol Chem 2019 Apr 4;80:234-243. Epub 2019 Apr 4.

School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China; Chongqing Key Laboratory of Targeted Drug Screening and Activity Evaluation, Chongqing, 400054, China; Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing, 400054, China. Electronic address:

Nowadays, different approaches have been pursued with the intent to develop sulfonamide-like carbonic anhydrase inhibitors that possess better selectivity profiles toward the different human isoforms of the enzyme. Here, we used conventional 3D-QSAR methods, including comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA), and Topomer CoMFA, to construct three-dimensional quantitative structure-activity relationship (3D-QSAR) models for benzenesulfonamide derivatives as human carbonic anhydrase (hCA) II/IX inhibitors. The theoretical models had good reliability (R>0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiolchem.2019.03.005DOI Listing

Protein corona variation in nanoparticles revisited: A dynamic grouping strategy.

Colloids Surf B Biointerfaces 2019 Apr 3;179:505-516. Epub 2019 Apr 3.

Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Bio-nano interface investigation models are mainly based on the type of proteins present on corona, bio-nano interaction responses and the evaluation of final outcomes. Due to the extensive diversity in correlative models for investigation of nanoparticles biological responses, a comprehensive model considering different aspects of bio-nano interface from nanoparticles properties to protein corona fingerprints appeared to be essential and cannot be ignored. In order to minimize divergence in studies in the era of bio-nano interface and protein corona with following therapeutic implications, a useful investigation model on the basis of RADAR concept is suggested. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2019.04.003DOI Listing

Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses.

Phytomedicine 2018 Nov 28;59:152774. Epub 2018 Nov 28.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address:

Background: Diabetes mellitus is a well-known risk factor for the development of heart failure. Inflammation and oxidative stress play a key role in the development of diabetic cardiomyopathy (DCM), and this nexus represents an attractive target to combat this disease. Naturally occurring flavonoid luteolin exhibits both anti-inflammatory and antioxidant activities in various systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2018.11.034DOI Listing
November 2018

Copper nanoparticles modify the blood plasma antioxidant status and modulate the vascular mechanisms with nitric oxide and prostanoids involved in Wistar rats.

Pharmacol Rep 2019 Feb 15;71(3):509-516. Epub 2019 Feb 15.

Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

Background: We aimed to analyze whether a diet supplemented with a standard dose of copper (Cu) in the form of nanoparticles, as an alternative to carbonate, exerts beneficial effects within the vasculature and improves the blood antioxidant status.

Methods: Male Wistar rats were fed for 8 weeks with a diet supplemented with Cu (6.5 mg Cu/kg in the diet) either as nanoparticles (40 nm diameter) or carbonate - the control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharep.2019.02.007DOI Listing
February 2019

Tip of the trichome: evolution of acylsugar metabolic diversity in Solanaceae.

Curr Opin Plant Biol 2019 Apr 19;49:8-16. Epub 2019 Apr 19.

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA; Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA. Electronic address:

Acylsugars are insecticidal plant specialized metabolites produced in the Solanaceae (nightshade family). Despite having simple constituents, these compounds are unusually structurally diverse. Their structural variations in phylogenetically closely related species enable comparative biochemical approaches to understand acylsugar biosynthesis and pathway diversification. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbi.2019.03.005DOI Listing

Salvianolic acid B inhibits Ang II-induced VSMC proliferation in vitro and intimal hyperplasia in vivo by downregulating miR-146a expression.

Phytomedicine 2018 Nov 12;58:152754. Epub 2018 Nov 12.

Department of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University, Shijiazhuang, Hebei 050017, China. Electronic address:

Background: Salvianolic acid B (Sal B), a water-soluble compound extracted from Salvia miltiorrhiza that has been widely used to treat cardiovascular diseases for hundreds of years in China, exerts cardiovascular protection by multiple mechanisms. miR-146a is involved in vascular smooth muscle cell (VSMC) phenotypic modulation and proliferation. However, it has yet to be investigated whether the cardiovascular protective effect of Sal B is mediated by miR-146a. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2018.11.014DOI Listing
November 2018

PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair.

DNA Repair (Amst) 2019 Apr 6;78:114-127. Epub 2019 Apr 6.

Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic; Laboratory of Genome Integrity, Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic; Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21, Stockholm, Sweden. Electronic address:

The bulk of DNA damage caused by ionizing radiation (IR) is generally repaired within hours, yet a subset of DNA lesions may persist even for long periods of time. Such persisting IR-induced foci (pIRIF) co-associate with PML nuclear bodies (PML-NBs) and are among the characteristics of cellular senescence. Here we addressed some fundamental questions concerning the nature and determinants of this co-association, the role of PML-NBs at such sites, and the reason for the persistence of DNA damage in human primary cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2019.04.001DOI Listing

In vitro susceptibility of Plasmodium falciparum isolates from the China-Myanmar border area to artemisinins and correlation with K13 mutations.

Int J Parasitol Drugs Drug Resist 2019 Apr 10;10:20-27. Epub 2019 Apr 10.

Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, Yunnan Province, 650500, China. Electronic address:

Mutations in the Kelch domain of the K13 gene (PF3D7_1343700) were previously associated with artemisinin resistance in Plasmodium falciparum. This study followed the dynamics of the K13 polymorphisms in P. falciparum parasites from the China-Myanmar border area obtained in 2007-2016, and their in vitro sensitivities to artesunate (AS) and dihydroartemisinin (DHA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpddr.2019.04.002DOI Listing

The value of manure - Manure as co-product in life cycle assessment.

J Environ Manage 2019 Apr 19;241:293-304. Epub 2019 Apr 19.

Innovation Center for U.S. Dairy, USA.

Livestock production is important for food security, nutrition, and landscape maintenance, but it is associated with several environmental impacts. To assess the risk and benefits arising from livestock production, transparent and robust indicators are required, such as those offered by life cycle assessment. A central question in such approaches is how environmental burden is allocated to livestock products and to manure that is re-used for agricultural production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.03.059DOI Listing

Identification and bioactivity of a granulocyte colony-stimulating factor b homologue from large yellow croaker (Larimichthys crocea).

Fish Shellfish Immunol 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, 361005, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address:

Granulocyte colony-stimulating factor (GCSF) is a pleiotropic cytokine that plays a key role in regulation of hematopoiesis, innate and adaptive immune responses in mammals. However, bioactivity of GCSF in teleost fish remains largely unknown. In this study, a GCSFb homologue from large yellow croaker (Larimichthys crocea) (LcGCSFb) was cloned by RACE-PCR techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fsi.2019.04.048DOI Listing

Comparative proteomic analysis of two sesame genotypes with contrasting salinity tolerance in response to salt stress.

J Proteomics 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China. Electronic address:

Sesame is one of the most important oilseed crops and has high nutritional value. The yield and quality of sesame are severely affected by high salinity in coastal and semi-arid/arid regions. In this study, the phenotypic, physiological, and proteomic changes induced by salt treatment were analyzed in salt-tolerant (G441) and salt-sensitive (G358) seedlings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jprot.2019.04.017DOI Listing

Metabolic and epigenetic reprogramming in the arsenic-induced cancer stem cells.

Semin Cancer Biol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, 48201, USA. Electronic address:

At present, the belief that genetic mutations control every aspect of tumorigenesis is still very popular. Even for the highly debated "bad luck" theory of cancers, it ascertained that random mutation of genes during the self-renewal of somatic stem cells is responsible for cancer initiation. Logically, most of the new therapeutic strategies so far, from molecular targeting to precision medicine or personalized medicine, are genome-obsessed and focused on identifying and targeting these mutated genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcancer.2019.04.003DOI Listing

Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapy.

Drug Discov Today 2019 Apr 19. Epub 2019 Apr 19.

Centre for Biosystems and Genome Network Medicine, Ioannina University, Ioannina, Greece; Department of Surgery, Ioannina University Hospital, Ioannina, Greece; Department of Systems Biology, Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens, Greece. Electronic address:

Progress in understanding and overcoming fatal intrinsic and acquired resistance is slow, with only a few exceptions. Despite advances in modern genome and transcriptome analysis, the controversy of the three different theories on drug resistance and tumor progression, namely dynamic intratumor heterogeneity, pre-existing minor genomic clones and tumor ecosystem, is unresolved. Moreover, evidence on transcriptional heterogeneity suggests the necessity of a drug bank for individualized, precise drug-sensitivity prediction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2019.04.008DOI Listing

Functional microglia neurotransmitters in amyotrophic lateral sclerosis.

Semin Cell Dev Biol 2019 Apr 19. Epub 2019 Apr 19.

Fondazione Santa Lucia IRCCS, Preclinical Neuroscience, Via Del Fosso di Fiorano 64, 00143, Rome, Italy. Electronic address:

Today neuroscience is dominated by the perspective that microglia are essential elements in any integrated view of the nervous system. A number of different neuroinflammatory conditions affect the CNS where microglia involvement, and particularly microgliosis, is not only a prominent feature, but also a pathogenic key mechanism of disease. On the other side, microglia can also constitute an important trigger of neuronal protection during neurodegenerative disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2019.04.014DOI Listing

A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent.

Mitochondrion 2019 Apr 19. Epub 2019 Apr 19.

Department of Inborn Errors of Metabolism, FSBI 'Research Centre for Medical Genetics', Moscow, Russia.

We present a 14-year-old girl with loss of motor functions, tetraplegia, epilepsy and nystagmus, caused by a novel heteroplasmic m.641A>T transition in an evolutionary conserved region of mitochondrial genome, affecting the aminoacyl stem of mitochondrial tRNA-Phe. In silico prediction, respirometry, Western blot and enzymatic analyses in skin fibroblasts support the pathogenicity of the m. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mito.2019.04.004DOI Listing

Functional implementation of a linear glycolysis for sugar catabolism in Pseudomonas putida.

Metab Eng 2019 Apr 19. Epub 2019 Apr 19.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kongens Lyngby, Denmark. Electronic address:

The core metabolism for glucose assimilation of the soil bacterium and platform strain Pseudomonas putida KT2440 has been reshaped from the native, cyclically-operating Entner-Doudoroff (ED) pathway to a linear Embden-Meyerhof-Parnas (EMP) glycolysis. The genetic strategy deployed to obtain a suitable host for the synthetic EMP route involved not only eliminating enzymatic activities of the ED pathway, but also erasing peripheral reactions for glucose oxidation that divert carbon skeletons into the formation of organic acids in the periplasm. Heterologous glycolytic enzymes, recruited from Escherichia coli, were genetically knocked-in in the mutant strain to fill the metabolic gaps for the complete metabolism of glucose to pyruvate through a synthetic EMP route. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymben.2019.04.005DOI Listing

Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: A redox signaling perspective.

Nitric Oxide 2019 Apr 19. Epub 2019 Apr 19.

New York University School of Medicine, New York, NY, USA.

Cancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammatory tumor microenvironment play an essential role in directly influencing intercellular and intracellular signaling. These reactive species originating in the cancer cell or its microenvironment, mediate the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.niox.2019.04.009DOI Listing

A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model.

J Ethnopharmacol 2019 Apr 19:111897. Epub 2019 Apr 19.

Pharmacen™, Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230, Odense M, Denmark; Celvivo IVS, Blommenslyst, Denmark. Electronic address:

Ethnopharmacology Relevance: Traditional herbal medicines are utilized by 27 million South Africans. Xysmalobium undulatum (Uzara) is one of the most widely used traditional medicinal plants in Southern Africa. A false belief in the safety of herbal medicine may result in liver injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.111897DOI Listing

Cost-effective care in eosinophilic esophagitis.

Authors:
Evan S Dellon

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2019.04.010DOI Listing

Interaction Between Microfilament and Microtubule- Dependent Tensions and Ischemia/Hypoxic-Induced Alteration of Structural Tension in Neuronal Cells.

Brain Res Bull 2019 Apr 19. Epub 2019 Apr 19.

Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing, PR China. Electronic address:

Intracellular mechanical tension plays a vital role in maintaining neuronal function and is generated steerablely by motor proteins along microfilaments (MFs) and microtubules (MTs). To explore the interaction between these subcellular tensions and elucidate their underlying mechanisms, we constructed MF- and MT-dependent tension probes using the Förster resonance energy transfer technique. Hypotonic stress activated MF and MT tensions in calcium-dependent manner, which antagonized outward expansion of cells synergistically; conversely, hypertonic stress attenuated MF and MT tensions in a calcium-independent manner and their interaction is antagonistical. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainresbull.2019.04.007DOI Listing

Untargeted LC-MS-based metabonomics revealed that aristolochic acid I induces testicular toxicity by inhibiting amino acids metabolism, glucose metabolism, β-oxidation of fatty acids and the TCA cycle in male mice.

Toxicol Appl Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Chinese Academy of Inspection and Quarantine, Institute of Chemicals Safety, Beijing, China. Electronic address:

As the main toxic component of aristolochic acid, aristolochic acid I (AAI) is primarily found in Aristolochiaceae plants such as Aristolochia, Aristolochia fangchi and Caulis aristolochiae manshuriensis. AAI has been proven to be carcinogenic, mutagenic and nephrotoxic. Although the role of AAI in testicular toxicity has been reported, its mechanism of action is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2019.04.014DOI Listing

Megaviruses: An involvement in phytohormone receptor gene transfer in brown algae?

Gene 2019 Apr 19. Epub 2019 Apr 19.

Groupe d'Etude des Interactions Hôte-Pathogène, GEIHP, EA3142, Univ Angers, SFR 4208 ICAT, Angers, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.04.055DOI Listing

Novel association of SNP rs479200 in EGLN1 gene with predisposition to preeclampsia.

Gene 2019 Apr 19. Epub 2019 Apr 19.

Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India. Electronic address:

Objectives: Placental hypoxia is a hallmark of preeclampsia. SNP rs479200 in the EGLN1 gene is associated with reduced responsiveness to hypoxia. Whether this translates into an association between SNP rs479200 and preeclampsia is not known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.04.049DOI Listing

Genome-wide annotation and comparative analysis of cuticular protein genes in the noctuid pest Spodoptera litura.

Insect Biochem Mol Biol 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing, 400716, China; Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing, 400716, China. Electronic address:

Insect cuticle is considered an adaptable and versatile building material with roles in the construction and function of exoskeleton. Its physical properties are varied, as the biological requirements differ among diverse structures and change during the life cycle of the insect. Although the bulk of cuticle consists basically of cuticular proteins (CPs) associated with chitin, the degree of cuticular sclerotization is an important factor in determining its physical properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ibmb.2019.04.012DOI Listing

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders.

Free Radic Biol Med 2019 Apr 19. Epub 2019 Apr 19.

Institute of Life Science, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK. Electronic address:

Cholestane-3β,5α,6β-triol (3β,5α,6β-triol) is formed from cholestan-5,6-epoxide (5,6-EC) in a reaction catalysed by cholesterol epoxide hydrolase, following formation of 5,6-EC through free radical oxidation of cholesterol. 7-Oxocholesterol (7-OC) and 7β-hydroxycholesterol (7β-HC) can also be formed by free radical oxidation of cholesterol. Here we investigate how 3β,5α,6β-triol, 7-OC and 7β-HC are metabolised to bile acids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.020DOI Listing

Differential expression patterns of sodium potassium ATPase alpha and beta subunit isoforms in mouse brain during postnatal development.

Neurochem Int 2019 Apr 19. Epub 2019 Apr 19.

Ruhr University Bochum, Faculty of Chemistry and Biochemistry, Biochemistry II, Bochum, Germany; Ruhr University Bochum, International Graduate School for Neuroscience, Germany. Electronic address:

The sodium potassium ATPase (Na/K ATPase) is essential for the maintenance of a low intracellular Na and a high intracellular K concentration. Loss of function of the Na/K ATPase due to mutations in Na/K ATPase genes, anoxic conditions, depletion of ATP or inhibition of the Na/K ATPase function using cardiac glycosides such as digitalis, causes a depolarization of the resting membrane potential. While in non-excitable cells, the uptake of glucose and amino acids is decreased if the function of the Na/K ATPase is compromised, in excitable cells the symptoms range from local hyper-excitability to inactivating depolarization. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01970186183045
Publisher Site
http://dx.doi.org/10.1016/j.neuint.2019.04.009DOI Listing
April 2019
1 Read

Oral gavage of capsaicin causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity in the mouse.

Physiol Behav 2019 Apr 19. Epub 2019 Apr 19.

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. Electronic address:

Capsaicin (CAP), the pungent ingredient of hot red pepper, is a selective ligand for the heat-sensitive transient receptor potential V1 cation channel 1 (TRPV1). Although CAP has been traditionally used as the ingredient of spices for various foods in the world, the effect of oral intake of CAP on thermoregulation and locomotor activity, and CAP-induced activation of brain neural circuits are not well understood. In this study, therefore, we examined the effects of oral gavage of CAP on core body and tail surface temperature, locomotor activity, and Fos expression in thermoregulation- and sensory information-associated hypothalamic and medullary brain regions using freely moving mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physbeh.2019.04.015DOI Listing

The sensilla trichodea-biased EoblPBP1 binds sex pheromones and green leaf volatiles in Ectropis obliqua Prout, a geometrid moth pest that uses Type-II sex pheromones.

J Insect Physiol 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Tea Quality and Safety Control, Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, 310008, China. Electronic address:

Pheromone-binding proteins (PBPs) are considered to play critical roles in sex pheromone detection. Lepidopteran moths can be divided into two taxa, those that use Type-I sex pheromones, such as C10-C18 unsaturated aldehydes, alcohols and acetates, and those that use Type-II pheromones, which are C17-C23 polyunsaturated hydrocarbons and their epoxide derivatives. To date, nearly all the characterized PBPs have been reported in moths with Type-I sex pheromones, and the physiological functions of PBPs in moths that use Type-II sex pheromones remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinsphys.2019.04.005DOI Listing

Metabolic and Behavioral Responses of Predators to Prey Nutrient Content.

J Insect Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Integrative Biology, Oklahoma State University, 501 Life Science West, Stillwater, Oklahoma, 74075, USA.

Predators feed on a diversity of prey that can vary widely in nutrient content. While prey nutrient content is known to have important consequences for life history traits, less is known about how it affects physiology and behavior. The purpose of this study was to test how diet affected the physiology and behavior of the wolf spider Hogna carolinensis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinsphys.2019.04.006DOI Listing

Development of lacrimal gland inflammation in the mouse model of herpes stromal keratitis.

Exp Eye Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA; Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

Herpes stromal keratitis (HSK) is a chronic immunoinflammatory condition which develops in response to recurrent herpes simplex virus-1 (HSV-1) infection of the cornea. Patients with HSK often demonstrate the concurrence of corneal desiccation and the loss of blink reflex. However, the relationship between severity of HSK, level of basal tears and inflammation of the lacrimal gland is mostly unexplored. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144835193013
Publisher Site
http://dx.doi.org/10.1016/j.exer.2019.04.022DOI Listing
April 2019
1 Read

Computational model of the dual action of PTH - Application to a rat model of osteoporosis.

J Theor Biol 2019 Apr 19. Epub 2019 Apr 19.

St Vincent's Department of Surgery, The University of Melbourne, Clinical Science Building, 29 Regent Street, Fitzroy VIC 3065, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, 2 George Street, Brisbane QLD 4000, Australia.

This paper presents a pharmacokinetic/pharmacodynamic (PK/PD) model of the action of PTH(1-34) on bone modelling and remodelling, developed for quantitatively investigating the dose- and administration pattern-dependency of the bone tissue response to this drug. Firstly, a PK model of PTH(1-34) was developed, accounting for administration via subcutaneous injections. Subsequently, the PK model was coupled to a (mechanistic) bone cell population model of bone modelling and remodelling, taking into account the effects of PTH(1-34) on the differentiation of lining cells into active osteoblasts, on the apoptosis of active osteoblasts, and on proliferation of osteoblast precursors, as well as on the key regulatory pathways of bone cell activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtbi.2019.04.020DOI Listing

A path to cooperation between China and Mongolia towards the control of echinococcosis under the Belt and Road Initiative.

Acta Trop 2019 Apr 19. Epub 2019 Apr 19.

London School of Hygiene and Tropical Medicine, United Kingdom.

Health is the core of development. Health cooperation between countries plays a pivotal role under the 'Belt and Road' Initiative. In 2013, China launched its Belt and Road Initiative to improve the international cooperation of which health was an important component. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0001706X183108
Publisher Site
http://dx.doi.org/10.1016/j.actatropica.2019.04.022DOI Listing
April 2019
1 Read

Refractive Laser-Assisted Cataract Surgery vs. Conventional Manual Surgery: Comparing Efficacy and Safety in 3144 Eyes.

Am J Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada; Uptown Eye Specialists, Vaughan, Canada. Electronic address:

Purpose: To report on outcomes of efficacy and safety in one of the largest series of eyes undergoing either conventional manual cataract surgery (MCS) or refractive femtosecond laser-assisted cataract surgery (ReLACS).

Design: Retrospective, consecutive, interventional comparative case series.

Methods: This study included 3144 consecutive eyes of which 1580 were treated via MCS and 1564 were treated via ReLACS at Uptown Surgical Centre in Vaughan, Canada. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2019.04.010DOI Listing

Tissue Clearing and Its Application to Bone and Dental Tissues.

J Dent Res 2019 Apr 22:22034519844510. Epub 2019 Apr 22.

1 Department of Restorative Sciences, School of Dentistry, Texas A&M University, Dallas, TX, USA.

Opaqueness of animal tissue can be attributed mostly to light absorption and light scattering. In most noncleared tissue samples, confocal images can be acquired at no more than a 100-µm depth. Tissue-clearing techniques have emerged in recent years in the neuroscience field. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0022034519844510DOI Listing

The Role of Exopolysaccharides in Oral Biofilms.

J Dent Res 2019 Apr 22:22034519845001. Epub 2019 Apr 22.

1 Department of Oral Biology, Center for Oral Biology Research, Rutgers School of Dental Medicine, Newark, NJ, USA.

The oral cavity contains a rich consortium of exopolysaccharide-producing microbes. These extracellular polysaccharides comprise a major component of the oral biofilm. Together with extracellular proteins, DNA, and lipids, they form the biofilm matrix, which contributes to bacterial colonization, biofilm formation and maintenance, and pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0022034519845001DOI Listing

Time for a change: patterns of sex expression, health and mortality in a sex-changing tree.

Ann Bot 2019 Apr 22. Epub 2019 Apr 22.

Department of Ecology, Evolution, & Natural Resources, Rutgers University, New Brunswick, NJ, USA.

Background And Aims: The ability of individuals to change sex during their lifetime is known as environmental sex determination (ESD). This represents a unique life history trait, allowing plants to allocate resources differentially to male and female functions across lifetimes, potentially maximizing fitness in response to changing environmental or internal cues. In this study, Acer pensylvanicum, a species with an unconfirmed sex determination system, was investigated to see what patterns in sex expression existed across multiple years, if there were sex-based differences in growth and mortality, and whether this species conformed to theoretical predictions that females are larger and in better condition. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/aob/advance-article/doi/10.1093/aob
Publisher Site
http://dx.doi.org/10.1093/aob/mcz037DOI Listing
April 2019
1 Read

A 4-Yr Survey of the Range of Ticks and Tick-Borne Pathogens in the Lehigh Valley Region of Eastern Pennsylvania.

J Med Entomol 2019 Apr 23. Epub 2019 Apr 23.

Suppan LLC, 3870 Kreidersville Road, Northampton, PA.

Questing ticks were surveyed by dragging in forested habitats within the Lehigh Valley region of eastern Pennsylvania for four consecutive summers (2015-2018). A high level of inter-annual variation was found in the density of blacklegged tick nymphs, Ixodes scapularis Say, with a high density of host-seeking nymphs (DON) in summer 2015 and 2017 and a relatively low DON in summer 2016 and 2018. Very few American dog ticks (Dermacentor variabilis Say) and Ixodes cookei Packard were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jme/tjz043DOI Listing

Six Month Abstinence Heterogeneity in the Best Quit Study.

Ann Behav Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background: Understanding the characteristics of smokers who are successful in quitting may help to increase smoking cessation rates.

Purpose: To examine heterogeneity in cessation outcome at 6 months following smoking cessation behavioral counseling with or without weight management counseling.

Methods: 2,540 smokers were recruited from a large quitline provider and then randomized to receive proactive smoking cessation behavioral counseling without or with two versions of weight management counseling. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/abm/advance-article/doi/10.1093/abm
Publisher Site
http://dx.doi.org/10.1093/abm/kaz014DOI Listing
April 2019
1 Read

Altering the levels of nuclear import factors in early Xenopus laevis embryos affects later development.

PLoS One 2019 22;14(4):e0215740. Epub 2019 Apr 22.

Department of Molecular Biology, University of Wyoming, Laramie, Wyoming, United States of America.

More than just a container for DNA, the nuclear envelope carries out a wide variety of critical and highly regulated cellular functions. One of these functions is nuclear import, and in this study we investigate how altering the levels of nuclear transport factors impacts developmental progression and organismal size. During early Xenopus laevis embryogenesis, the timing of a key developmental event, the midblastula transition (MBT), is sensitive to nuclear import factor levels. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215740PLOS

Tempol treatment shows phenotype improvement in mdx mice.

PLoS One 2019 22;14(4):e0215590. Epub 2019 Apr 22.

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Considering potential Tempol effects on mdx muscle fibers, in this study we evaluated its effects on relevant dystrophic phenotypic characteristics, such as muscle degeneration, inflammatory process and angiogenesis, which as yet have not been investigated. Mdx mice were randomly assigned into three groups: mdxS, the control group receiving intraperitoneal (i.p. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215590PLOS

Predicting childhood obesity using electronic health records and publicly available data.

PLoS One 2019 22;14(4):e0215571. Epub 2019 Apr 22.

NYU Langone Comprehensive Program on Obesity, NYU School of Medicine, New York, New York, United States of America.

Background: Because of the strong link between childhood obesity and adulthood obesity comorbidities, and the difficulty in decreasing body mass index (BMI) later in life, effective strategies are needed to address this condition in early childhood. The ability to predict obesity before age five could be a useful tool, allowing prevention strategies to focus on high risk children. The few existing prediction models for obesity in childhood have primarily employed data from longitudinal cohort studies, relying on difficult to collect data that are not readily available to all practitioners. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215571PLOS

Pupylated proteins are subject to broad proteasomal degradation specificity and differential depupylation.

PLoS One 2019 22;14(4):e0215439. Epub 2019 Apr 22.

Institute of Molecular Biology and Biophysics, Department of Biology, ETHZ, Zurich, Switzerland.

In actinobacteria, post-translational modification of proteins with prokaryotic ubiquitin-like protein Pup targets them for degradation by a bacterial proteasome assembly consisting of the 20S core particle (CP) and the mycobacterial proteasomal ATPase (Mpa). Modification of hundreds of cellular proteins with Pup at specific surface lysines is carried out by a single Pup-ligase (PafA, proteasome accessory factor A). Pupylated substrates are recruited to the degradative pathway by binding of Pup to the N-terminal coiled-coil domains of Mpa. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215439PLOS

A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection.

PLoS Negl Trop Dis 2019 Apr 22;13(4):e0007345. Epub 2019 Apr 22.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

Background: Human hookworms (Necator americanus, Ancylostoma duodenale, and Ancylostoma ceylanicum) are intestinal blood-feeding parasites that infect ~500 million people worldwide and are among the leading causes of iron-deficiency anemia in the developing world. Drugs are useful against hookworm infections, but hookworms rapidly reinfect people, and the parasites can develop drug resistance. Therefore, having a hookworm vaccine would be of tremendous benefit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0007345DOI Listing
  • Page 1 of 33591