1,831,497 results match your criteria Biology And Environment-proceedings Of The Royal Irish Academy[Journal]


Why is arabica coffee visited by so few non-Apis bees in its native range?

Ecology 2020 May 26:e03103. Epub 2020 May 26.

Department of Biology, Lund University, 223 62, Lund, Sweden.

The current knowledge about pollinators in sub-Saharan Africa is extremely scarce. General pollinator distributions and resource usages are mainly unknown, as are the main pollinators of different crops (Timberlake and Morgan 2018). In early 2011, I travelled to an Afromontane area of Ethiopia, where arabica coffee, Coffea arabica L. Read More

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http://dx.doi.org/10.1002/ecy.3103DOI Listing

Full lifetime perspectives on the costs and benefits of lay date variation in tree swallows.

Ecology 2020 May 26. Epub 2020 May 26.

Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, TN, 37996, USA.

Animals must balance various costs and benefits when deciding when to breed. The costs and benefits of breeding at different times have received much attention, but most studies have been limited to investigating short-term season-to-season fitness effects. However, breeding early, versus late, in a season may influence lifetime fitness over many years, trading off in complex ways across the breeder's lifepan. Read More

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http://dx.doi.org/10.1002/ecy.3109DOI Listing

Historical comparisons of body size are sensitive to data availability and ecological context.

Ecology 2020 May 26. Epub 2020 May 26.

Hopkins Marine Station, Stanford University, 120 Ocean View Blvd, Pacific Grove, CA, 93940, USA.

Historical comparisons of body size often lack pertinent details, including information on the sampling protocol and relevant ecological covariates that influence body size. Moreover, historical estimates of body size that rely on museum specimens may be biased towards larger size classes due to collector preferences, and thus size thresholds have been used to focus attention on maximum body size. We tested the consequences of sampling design, ecological covariates, and size thresholds on inferences of body size change using field-contextualized historical records, rather than museum specimens. Read More

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http://dx.doi.org/10.1002/ecy.3101DOI Listing

Changes in stream food-web structure across a gradient of acid mine drainage increases local community stability.

Ecology 2020 May 26. Epub 2020 May 26.

School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.

Understanding what makes food webs stable has long been a goal of ecologists. Topological structure and the distribution and magnitude of interaction strengths in food webs have been shown to confer important stabilizing properties. However, our understanding of how variable species interactions affect food-web structure and stability is still in its infancy. Read More

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http://dx.doi.org/10.1002/ecy.3102DOI Listing

Warming acts through earlier snowmelt to advance but not extend alpine community flowering.

Ecology 2020 May 26. Epub 2020 May 26.

Energy and Resources Group, University of California Berkeley, 310 Barrows Hall, Berkeley, CA, 94720-3050, USA.

Large-scale warming will alter multiple local climate factors in alpine tundra, yet very few experimental studies examine the combined yet distinct influences of earlier snowmelt, higher temperatures and altered soil moisture on alpine ecosystems. This limits our ability to predict responses to climate change by plant species and communities. To address this gap, we used infrared heaters and manual watering in a fully factorial experiment to determine the relative importance of these climate factors on plant flowering phenology, and response differences among plant functional groups. Read More

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http://dx.doi.org/10.1002/ecy.3108DOI Listing

Does Formation of Multicellular Colonies by Choanoflagellates Affect Their Susceptibility to Capture by Passive Protozoan Predators?

J Eukaryot Microbiol 2020 May 26. Epub 2020 May 26.

Department of Integrative Biology, University of California, Berkeley, California, 94720-3140, USA.

Microbial eukaryotes, critical links in aquatic food webs, are unicellular, but some, such as choanoflagellates, form multicellular colonies. Are there consequences to predator avoidance of being unicellular versus forming larger colonies? Choanoflagellates share a common ancestor with animals and are used as model organisms to study the evolution of multicellularity. Escape in size from protozoan predators is suggested as a selective factor favoring evolution of multicellularity. Read More

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http://dx.doi.org/10.1111/jeu.12808DOI Listing

Year effects: Inter-annual variation as a driver of community assembly dynamics.

Ecology 2020 May 26. Epub 2020 May 26.

Department of Plant Sciences, University of California, Davis, CA, 95616, USA.

Environmental conditions that vary from year-to-year can be strong drivers of ecological dynamics, including the composition of newly assembled communities. However, ecologists often chalk such dynamics up to "noise" in ecological experiments. Our lack of attention to such "year effects" hampers our understanding of contingencies in ecological assembly mechanisms and limits the generalizability of research findings. Read More

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http://dx.doi.org/10.1002/ecy.3104DOI Listing

Superior haplotypes for haplotype-based breeding for drought tolerance in pigeonpea (Cajanus cajan L.).

Plant Biotechnol J 2020 May 26. Epub 2020 May 26.

Center of Excellence in Genomics & Systems Biology (CEGSB), International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, 502324, Telangana State, India.

Haplotype-based breeding, a recent promising breeding approach to develop tailored made crop varieties deals with identification of superior haplotypes and their deployment in breeding programs. In this context, whole genome re-sequencing data of 292 genotypes from pigeonpea reference set was mined to identify the superior haplotypes for 10 drought-responsive candidate genes. A total of 83, 132 and 60 haplotypes were identified in breeding lines, landraces and wild species, respectively. Read More

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http://dx.doi.org/10.1111/pbi.13422DOI Listing

Quantitative Redox Biology of Exercise.

Int J Sports Med 2020 May 26. Epub 2020 May 26.

Centre for Atherothrombotic & Metabolic Disease, Hull York Medical School, Hull, United Kingdom of Great Britain and Northern Ireland.

Biology is rich in claims that reactive oxygen and nitrogen species are involved in every biological process and disease. However, many quantitative aspects of redox biology remain elusive. The important quantitative parameters you need to address the feasibility of redox reactions in vivo are: rate of formation and consumption of a reactive oxygen and nitrogen species, half-life, diffusibility and membrane permeability. Read More

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http://dx.doi.org/10.1055/a-1157-9043DOI Listing

Cell shape, and not 2D migration, predicts extracellular matrix-driven 3D cell invasion in breast cancer.

APL Bioeng 2020 Jun 5;4(2):026105. Epub 2020 May 5.

Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, USA.

Metastasis, the leading cause of death in cancer patients, requires the invasion of tumor cells through the stroma in response to migratory cues, in part provided by the extracellular matrix (ECM). Recent advances in proteomics have led to the identification of hundreds of ECM proteins, which are more abundant in tumors relative to healthy tissue. Our goal was to develop a pipeline to easily predict which ECM proteins are more likely to have an effect on cancer invasion and metastasis. Read More

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http://dx.doi.org/10.1063/1.5143779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202897PMC

Anti-inflammatory, Antiplatelet Aggregation, and Antiangiogenesis Polyketides from : Toward an Understating of Its Biological Activities and Potential Applications.

ACS Omega 2020 May 6;5(19):11092-11099. Epub 2020 May 6.

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

The ethyl acetate extract of an endophyte exhibited anti-inflammatory activity at a concentration of <10 μg/mL. By bioassay-guided fractionation, one new compound, named epicorepoxydon A (), and one unusual bioactive compound, 6-(hydroxymethyl)benzene-1,2,4-triol (), together with six known compounds, were isolated from . The structures of all isolates were established by spectroscopic analyses. Read More

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http://dx.doi.org/10.1021/acsomega.0c01000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241018PMC

Draft Genome of the Liver Fluke .

ACS Omega 2020 May 6;5(19):11084-11091. Epub 2020 May 6.

Molecular and Structural Biophysics Laboratory, Department of Biochemistry, North-Eastern Hill University, Shillong 793022, India.

Fascioliasis, a neglected foodborne disease caused by liver flukes (genus ), affects more than 200 million people worldwide. Despite technological advances, little is known about the molecular biology and biochemistry of these flukes. We present the draft genome of for the first time. Read More

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http://dx.doi.org/10.1021/acsomega.0c00980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241025PMC

Preparation of Highly Porous Graphitic Activated Carbon as Electrode Materials for Supercapacitors by Hydrothermal Pretreatment-Assisted Chemical Activation.

ACS Omega 2020 May 6;5(19):11058-11067. Epub 2020 May 6.

Key Laboratory of Straw Biology and Utilization, The Ministry of Education, Jilin Agricultural University, Changchun 130118, China.

The obstruction of traditional chemical activation lies in the addition of excessive catalysts to prepare the highly porous graphitic activated carbon (HPGAC), we propose the hydrothermal pretreatment-assisted chemical activation method to synthesize HPGAC as electrode materials using a small amount of Na-based catalysts (20 wt %). Hydrolysis accompanied by the strong depolymerization and reorganization of the coal framework is beneficial to the removal of different kinds of oxygen-containing structures (including cross-linking bonds, functional groups, and heterocycles) from lignite; thus, the deoxidization effect of hydrothermal carbonization (HTC) on hydrochar gradually strengthens with the increase in pretreatment temperature from 180 to 300 °C, resulting in the formation of a lot of disordered nanostructures and a smooth and compact surface. In the subsequent chemical activation stage, the microstructure of hydrochar is beneficial to the formation of a lot of graphene-like sheets and developed micropores even under a small amount of Na-based catalysts (20 wt %). Read More

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http://dx.doi.org/10.1021/acsomega.0c00938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241011PMC

Total Synthesis of Naturally Occurring 5,7,8-Trioxygenated Homoisoflavonoids.

ACS Omega 2020 May 6;5(19):11043-11057. Epub 2020 May 6.

College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.

Homoisoflavonoids are in the subclass of the larger family of flavonoids but have one more alkyl carbon than flavonoids. Among them, 5,7,8-trioxygenated homoisoflavonoids have not been extensively studied for synthesis and biological evaluation. Our current objective is to synthesize 2 5,7,8-trioxygenated chroman-4-ones and 12 5,7,8-trioxygenated homoisoflavonoids that have been isolated from the plants , , , , , , , , and . Read More

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http://dx.doi.org/10.1021/acsomega.0c00932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241036PMC

Tungsten Oxide Nanodots Exhibit Mild Interactions with WW and SH3 Modular Protein Domains.

ACS Omega 2020 May 8;5(19):11005-11012. Epub 2020 May 8.

Institute of Quantitative Biology, Zhejiang University, Hangzhou 310027, China.

Tungsten oxide nanodot (WO ) is an active photothermal nanomaterial that has recently been discovered as a promising candidate for tumor theranostics and treatments. However, its potential cytotoxicity remains elusive and needs to be evaluated to assess its biosafety risks. Herein, we investigate the interactions between WO and two ubiquitous protein domains involved in protein-protein interactions, namely, WW and SH3 domains, using atomistic molecular dynamics simulations. Read More

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http://dx.doi.org/10.1021/acsomega.0c00822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241039PMC

Ginsenoside Rg1 Regulates Liver Lipid Factor Metabolism in NAFLD Model Rats.

ACS Omega 2020 May 5;5(19):10878-10890. Epub 2020 May 5.

Department of Human Anatomy, College of Basic Medical Sciences, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541004, P. R. China.

To establish the molecular mechanism of ginsenoside Rg1 in nonalcoholic fatty liver disease (NAFLD), Sprague Dawley (SD) rats (180-220 g) were randomly divided into a control group, model group, ginsenoside Rg1 low-dose group (30 mg/(kg day)), high-dose (60 mg/(kg day)) group, and simvastatin group (1 mg/(kg day)), with 10 SD rats in each group. The control group was given a normal diet. The model group rats were given high-sugar and high-fat diets for 14 weeks. Read More

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http://dx.doi.org/10.1021/acsomega.0c00529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241038PMC

HyperQuant-A Computational Pipeline for Higher Order Multiplexed Quantitative Proteomics.

ACS Omega 2020 May 7;5(19):10857-10867. Epub 2020 May 7.

Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad 121001, Haryana, India.

Quantitative proteomics has evolved considerably over the last decade with the advent of higher order multiplexing (HOM) techniques. With the development of methods such as-multitagging, cPILOT, hyperplexing, BONPlex, and MITNCAT, the HOM technique is rapidly taking the center stage in multiplexed quantitative proteomics. These studies combined MS and MS labels in a single experiment enabling higher sample throughput. Read More

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http://dx.doi.org/10.1021/acsomega.0c00515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240821PMC

Influence of Binding Site Affinity Patterns on Binding of Multivalent Polymers.

ACS Omega 2020 May 6;5(19):10774-10781. Epub 2020 May 6.

Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

Using inspiration from biology, we can leverage multivalent binding interactions to enhance weak, monovalent binding between molecules. While most previous studies have focused on multivalent binders with uniform binding sites, new synthetic polymers might find it desirable to have multiple binding moieties along the chain. Here, we probe how patterning of heterogeneous binding sites along a polymer chain controls the binding affinity of a polymer using a reactive Brownian dynamics scheme. Read More

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http://dx.doi.org/10.1021/acsomega.0c00334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240832PMC

Cytotoxic effect of selected wild orchids on two different human cancer cell lines.

Heliyon 2020 May 17;6(5):e03991. Epub 2020 May 17.

Central Department of Botany, Tribhuvan University, Kirtipur, Kathmandu, Nepal.

Majority of the orchid species are used in the traditional medicines for the treatment of several diseases. They are the sources of polysaccharides, phenanthrenes, bibenzyl derivatives, revesteral, stilbenoids and polyphenol compounds. This study explored the cytotoxic activity of seven wild orchid species and identification of medicinally active compounds. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235618PMC

Effects of light intensities and varying watering intervals on growth, tissue nutrient content and antifungal activity of hydroponic cultivated L. under greenhouse conditions.

Heliyon 2020 May 17;6(5):e03906. Epub 2020 May 17.

Department of Horticulture Sciences, Faculty of Applied Sciences, Cape Peninsula University of Technology, Symphony Way, Bellville, 7535, Cape Town, South Africa.

Optimization of the quality and quantity of medicinal materials during cultivation could improve the value of medicinal plants. Light intensity and water availability affect physiological processes and growth of plants. L. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235940PMC

The ubiquitous role of mitochondria in Parkinson and other neurodegenerative diseases.

AIMS Neurosci 2020 25;7(1):43-65. Epub 2020 Mar 25.

Department of Informatics, Ionian University, Plateia Tsirigoti 7, 49100, Corfu, Greece.

Orderly mitochondrial life cycle, plays a key role in the pathology of neurodegenerative diseases. Mitochondria are ubiquitous in neurons as they respond to an ever-changing demand for energy supply. Mitochondria constantly change in shape and location, feature of their dynamic nature, which facilitates a quality control mechanism. Read More

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http://dx.doi.org/10.3934/Neuroscience.2020004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242057PMC

Gut neurotoxin p-cresol induces differential expression of GLUN2B and GLUN2A subunits of the NMDA receptor in the hippocampus and nucleus accumbens in healthy and audiogenic seizure-prone rats.

AIMS Neurosci 2020 10;7(1):30-42. Epub 2020 Mar 10.

Institute of Chemical Biology, Ilia State University, 3/5 Cholokashvili av, Tbilisi, 0162, Georgia.

Mislocalization and abnormal expression of N-methyl-D-aspartate glutamate receptor (NMDAR) subunits is observed in several brain disorders and pathological conditions. Recently, we have shown that intraperitoneal injection of the gut neurotoxin p-cresol induces autism-like behavior and accelerates seizure reactions in healthy and epilepsy-prone rats, respectively. In this study, we evaluated the expression of GLUN2B and GLUN2A NMDAR subunits, and assessed the activity of cAMP-response element binding protein (CREB) and Rac1 in the hippocampi and nucleus accumbens of healthy and epilepsy-prone rats following p-cresol administration. Read More

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http://dx.doi.org/10.3934/Neuroscience.2020003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242059PMC

The many faces of thyroxine.

AIMS Neurosci 2020 3;7(1):17-29. Epub 2020 Mar 3.

Biology Department, Center for Computational and Integrative Biology, Rutgers University, 315 Penn St., Camden, NJ 08102, USA.

Hönes et al. have recently shown that interference with the apparatus of the nuclear receptor-mediated, gene-driven mechanism of triiodothyronine (T3) actions fails to eliminate all actions of T3. However, the investigators conducting that study provided little information regarding the mechanisms that might be responsible for conferring those implied gene-independent effects. Read More

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http://dx.doi.org/10.3934/Neuroscience.2020002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242060PMC

DNA Vaccine Treatment in Dogs Experimentally Infected with .

J Immunol Res 2020 5;2020:9794575. Epub 2020 May 5.

Department of Molecular Biology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano No. 1, Col. Sección XVI, Tlalpan, 14080 Mexico City, Mexico.

Chagas disease is a chronic and potentially lethal disorder caused by the parasite , and an effective treatment has not been developed for chronic Chagas disease. The objective of this study was to determine the effectiveness of a therapeutic DNA vaccine containing genes in dogs with experimentally induced Chagas disease through clinical, pathological, and immunological analyses. Infection of Beagle dogs with the H8 strain was performed intraperitoneally with 3500 metacyclic trypomastigotes/kg body weight. Read More

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http://dx.doi.org/10.1155/2020/9794575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222601PMC

Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors.

J Immunol Res 2020 6;2020:7471380. Epub 2020 May 6.

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, USA 29425.

An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs). To evaluate microbial translocation in HIV, we assessed lipopolysaccharide (LPS) immunohistochemistry staining in lymph nodes. Read More

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http://dx.doi.org/10.1155/2020/7471380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225845PMC

Identification of Susceptibility Modules and Genes for Cardiovascular Disease in Diabetic Patients Using WGCNA Analysis.

J Diabetes Res 2020 10;2020:4178639. Epub 2020 May 10.

Department of Endocrinology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objective: To identify susceptibility modules and genes for cardiovascular disease in diabetic patients using weighted gene coexpression network analysis (WGCNA).

Methods: The raw data of GSE13760 were downloaded from the Gene Expression Omnibus (GEO) website. Genes with a false discovery rate < 0. Read More

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http://dx.doi.org/10.1155/2020/4178639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238331PMC

Effect of Essential Oil Supplementation on the Advanced Parameters of Mobility and on the Integrity of Human Sperm DNA.

Int J Reprod Med 2020 13;2020:1230274. Epub 2020 May 13.

Laboratory of Physiopathology, Genetics Molecular and Biotechnology (PGMB), Faculty of Sciences Ain Chock, Research Center Health and Biotechnology, University Hassan II of Casablanca, Morocco.

The reduced sperm mobility is one of the most important causes of male infertility. Several reports have indicated that the treatment of subnormal sperm samples with certain agents prior to artificial insemination significantly improves the fertilizing potential of sperm. We have among others some stimulants such as pentoxifylline, relaxin, prostaglandin E, and diltiazem. Read More

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http://dx.doi.org/10.1155/2020/1230274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243007PMC

Genome-Wide Analysis, Characterization, and Expression Profile of the Basic Leucine Zipper Transcription Factor Family in Pineapple.

Int J Genomics 2020 11;2020:3165958. Epub 2020 May 11.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian Province, China.

This study identified 57 basic leucine zipper (bZIP) genes from the pineapple genome, and the analysis of these bZIP genes was focused on the evolution and divergence after multiple duplication events in relation to the pineapple genome fusion. According to bioinformatics analysis of a phylogenetic tree, the bZIP gene family was divided into 11 subgroups in pineapple, , and rice; gene structure and conserved motif analyses showed that bZIP genes within the same subgroup shared similar intron-exon organizations and motif composition. Further synteny analysis showed 17 segmental duplication events with 27 bZIP genes. Read More

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http://dx.doi.org/10.1155/2020/3165958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238347PMC

Multiple umbilical cord-derived MSCs administrations attenuate rat osteoarthritis progression via preserving articular cartilage superficial layer cells and inhibiting synovitis.

J Orthop Translat 2020 Jul 23;23:21-28. Epub 2020 Apr 23.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.

Background/objectives: Articular cartilage erosion probably plays a substantial role in osteoarthritis (OA) initiation and development. Studies demonstrated that umbilical cord-derived mesenchymal stem cells (UCMSCs) could delay chondrocytes apoptosis and ameliorate OA progression in patients, but the detailed mechanisms are largely uncharacterised. In this study, we aimed to study the effects of UCMSCs on monosodium iodoacetate (MIA)-induced rat OA model, and explore the cellular mechanism of this effect. Read More

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http://dx.doi.org/10.1016/j.jot.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235619PMC

Branch point control at malonyl-CoA node: A computational framework to uncover the design principles of an ideal genetic-metabolic switch.

Authors:
Peng Xu

Metab Eng Commun 2020 Jun 24;10:e00127. Epub 2020 Apr 24.

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, Baltimore, MD 21250, USA.

Living organism is an intelligent system coded by hierarchically-organized information to perform precisely-controlled biological functions. Biophysical models are important tools to uncover the design rules underlying complex genetic-metabolic circuit interactions. Based on a previously engineered synthetic malonyl-CoA switch (Xu et al. Read More

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http://dx.doi.org/10.1016/j.mec.2020.e00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236061PMC

Argonaute proteins: Structural features, functions and emerging roles.

J Adv Res 2020 Jul 29;24:317-324. Epub 2020 Apr 29.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, China.

Argonaute proteins are highly conserved in almost all organisms. They not only involve in the biogenesis of small regulatory RNAs, but also regulate gene expression and defend against foreign pathogen invasion via small RNA-mediated gene silencing pathways. As a key player in these pathways, the abnormal expression and/or mis-modifications of Argonaute proteins lead to the disorder of small RNA biogenesis and functions, thus influencing multiply biological processes and disease development, especially cancer. Read More

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http://dx.doi.org/10.1016/j.jare.2020.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235612PMC

Long-term response to Olaparib in carcinomatous meningitis of a mutated ovarian cancer: A case report.

Mol Clin Oncol 2020 Jul 27;13(1):73-75. Epub 2020 Apr 27.

Department of Medical Oncology, Georges-François Leclerc Anticancer Center, UNICANCER, F-21079 Dijon, France.

PARP inhibitors are considered as a treatment revolution in ovarian cancer management. Leptomeningeal metastasis is a rare event with poor prognosis. The present report presents an exceptional history of long term survival for a young patient treated with olaparib for carcinomatous meningitis. Read More

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http://dx.doi.org/10.3892/mco.2020.2035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241237PMC

Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development.

Oxid Med Cell Longev 2020 12;2020:7191080. Epub 2020 May 12.

Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany.

CNS inflammation is a major driver of MS pathology. Differential immune responses, including the adaptive and the innate immune system, are observed at various stages of MS and drive disease development and progression. Next to these immune-mediated mechanisms, other mediators contribute to MS pathology. Read More

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http://dx.doi.org/10.1155/2020/7191080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240663PMC

Paternal Resistance Training Induced Modifications in the Left Ventricle Proteome Independent of Offspring Diet.

Oxid Med Cell Longev 2020 4;2020:5603580. Epub 2020 May 4.

Laboratory of Molecular Analysis, Graduate Program of Sciences and Technology of Health, Universidade de Brasília, Distrito Federal, Brazil.

Ancestral obesogenic exposure is able to trigger harmful effects in the offspring left ventricle (LV) which could lead to cardiovascular diseases. However, the impact of the father's lifestyle on the offspring LV is largely unexplored. The aim of this study was to investigate the effects of 8 weeks of paternal resistance training (RT) on the offspring left ventricle (LV) proteome exposed to control or high-fat (HF) diet. Read More

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http://dx.doi.org/10.1155/2020/5603580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218999PMC

Implications of NAD Metabolism in the Aging Retina and Retinal Degeneration.

Oxid Med Cell Longev 2020 9;2020:2692794. Epub 2020 May 9.

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Nicotinamide adenine dinucleotide (NAD) plays an important role in various key biological processes including energy metabolism, DNA repair, and gene expression. Accumulating clinical and experimental evidence highlights an age-dependent decline in NAD levels and its association with the development and progression of several age-related diseases. This supports the establishment of NAD as a critical regulator of aging and longevity and, relatedly, a promising therapeutic target to counter adverse events associated with the normal process of aging and/or the development and progression of age-related disease. Read More

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http://dx.doi.org/10.1155/2020/2692794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238357PMC

Association of , , , and Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome.

Dis Markers 2020 5;2020:6076274. Epub 2020 May 5.

Department of Biological Sciences, Faculty of Science, Beirut Arab University, Lebanon.

Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and RSA remains uncertain. Read More

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http://dx.doi.org/10.1155/2020/6076274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232732PMC

UNaProd: A Universal Natural Product Database for of Iranian Traditional Medicine.

Evid Based Complement Alternat Med 2020 13;2020:3690781. Epub 2020 May 13.

Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Iranian traditional medicine (ITM) is a holistic medical system that uses a wide range of medicinal substances to treat disease. Reorganization and standardization of the data on ITM concepts is a necessity for optimal use of this rich source. In an initial step towards this goal, we created a database of ITM . Read More

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http://dx.doi.org/10.1155/2020/3690781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243028PMC

Styrene Oxide Caused Cell Cycle Arrest and Abolished Myogenic Differentiation of C2C12 Myoblasts.

J Toxicol 2020 11;2020:1807126. Epub 2020 May 11.

Department of Anatomy, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand.

Contaminations of chemicals in foods and drinks are raising public concerns. Among these, styrene, a monomer for plastic production, receives increasing interest due to its ability to leach from the packaging and contaminate in foods and drinks causing many health problems. The present study was designed to investigate the effects of styrene monomer (STR) and its metabolite styrene oxide (STO) on C2C12 myoblast proliferation and differentiation. Read More

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http://dx.doi.org/10.1155/2020/1807126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238348PMC

Abundance, Diversity, and Distribution of Primates at Welel Mountain, Kellem Wollega Zone, Oromia Region, Ethiopia.

ScientificWorldJournal 2020 11;2020:5691324. Epub 2020 May 11.

Department of Biology, College of Natural and Computational Sciences, Raya University, P.O. Box 92, Maichew, Ethiopia.

Primates are the mammals of the order Primate that is characterized by advanced development of binocular vision and enlargement of the cerebral hemispheres. The aim of this study was to investigate the abundance, diversity, and distribution of primates on Welel Mountain. From August 2017 to February 2018, we collected data from different parts of Welel Mountain during wet and dry seasons of the year and analyzed them using SPSS version 20. Read More

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http://dx.doi.org/10.1155/2020/5691324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238318PMC

Macrophylloflavone: A New Biflavonoid from Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities.

ScientificWorldJournal 2020 12;2020:2983129. Epub 2020 May 12.

Department of Chemistry Education, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.

Investigations of antibacterial, antioxidant, and anti-type 2 diabetes mellitus activities have been carried out on Mart. plant extract fractions. An isolate from a fraction of ethyl acetate extract was characterized with spectroscopic data. Read More

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http://dx.doi.org/10.1155/2020/2983129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240784PMC

Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD.

Mediators Inflamm 2020 8;2020:4260204. Epub 2020 May 8.

Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, China.

Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). Read More

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http://dx.doi.org/10.1155/2020/4260204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231193PMC

Ethnobotanical Study of Medicinal Plants in Aziziye District (Erzurum, Turkey).

Turk J Pharm Sci 2020 Apr 24;17(2):211-220. Epub 2020 Apr 24.

Atatürk University, Faculty of Science, Department of Biology, Erzurum, Turkey.

Objectives: The present research was conducted to document the usage of medicinal plants, plant parts utilized, and methods of preparation by the people living in Aziziye district, situated in the western part of Erzurum.

Materials And Methods: The medicinal plant species utilized by local public for remedial aims were collected and identified. The related knowledge about conventional herbal medicine was collected, herbarium materials were prepared, and they were deposited in the Herbarium of the Faculty of Science, Atatürk University. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2019.24392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227921PMC

Assessment of Antigenotoxic Effect of Oil.

Turk J Pharm Sci 2020 Feb 19;17(1):115-118. Epub 2020 Feb 19.

Lokman Hekim University, Department of Medical Biology, Ankara, Turkey.

Objectives: Cyclophosphamide (CP) is an alkylating agent widely used as an antineoplastic and immunosuppressive agent. The genotoxicity of CP has been studied in a variety of and systems and is routinely used as a positive control in genotoxicity tests. Traditional medicine (), Ranunculaceae family, especially in the Eastern Mediterranean countries, especially in many countries, and is widely used in many countries as a spice and folk medicine since the time of Dioscorides used as a plant. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2020.09471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227873PMC
February 2020

Considering the Effect of Mill. Essential Oil on Oxidative Stress and Gene Expression in the Liver of Septic Rats.

Turk J Pharm Sci 2019 Dec 11;16(4):416-424. Epub 2019 Nov 11.

Payame-e-Noor University, Faculty of Sciences, Department of Biochemistry, Tehran, Iran.

Objectives: Sepsis is a clinical illness with a high rate of mortality all over the world. Oxidative stress is considered the main phenomenon that occurs in sepsis. Mill. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.58815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227890PMC
December 2019

Macrophage Nitric Oxide and Interleukin-1 Beta Suppression by Seed.

Turk J Pharm Sci 2019 Sep 10;16(3):362-365. Epub 2019 Jul 10.

University of Baghdad, Faculty of Science, Department of Biology, Baghdad, Iraq.

Objectives: has long been used in folk medicine to treat diseases including fever, headache, burns, constipation, gut pains, and inflammation. Nitric oxide (NO) and interleukin-1β (IL-1β) play an important role in the pathophysiology of inflammation. The objectives of this study were to determine the effect of seed ethanolic extract (MPSE) on the viability of and NO and IL-1β production by lipopolysaccharide (LPS)-activated macrophage (J774A. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.52244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227941PMC
September 2019

Effect of Extracts of the Aerial Parts and Roots from Four Species on Erectile Dysfunction in Rats with Streptozotocin-Induced Diabetes.

Turk J Pharm Sci 2019 Sep 10;16(3):317-325. Epub 2019 Jul 10.

Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Ankara, Turkey.

Objectives: The extracts of species are used as aphrodisiacs in Turkey and so we aimed to demonstrate and the relaxant effect of four species' extracts on the corpus cavernosum (CC).

Materials And Methods: A total of 30 adult male Sprague Dawley rats were divided into control and diabetic groups. Diabetes was induced by a single intraperitoneal injection of 40 mg/kg streptozotocin. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.26879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227944PMC
September 2019

The Anticancer and Anti-inflammatory Effects of Extract on Human Cancer Cell Lines.

Turk J Pharm Sci 2019 Sep 10;16(3):273-281. Epub 2019 Jul 10.

Muğla Sıtkı Koçman University, Department of Biology, Division of Molecular Biology and Biotechnology, Muğla, Turkey.

Objectives: Natural products originating from plants have been used for many years in the treatment of various diseases, including cancer. subsp. is used in Turkish folk medicine. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.27146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227956PMC
September 2019

Essential Oil and Fatty Acid Composition of Endemic Schreb. from Turkey.

Turk J Pharm Sci 2019 Jun 27;16(2):220-226. Epub 2019 Mar 27.

Yıldız Technical University, Faculty of Arts and Science, Department of Molecular Biology and Genetics, İstanbul, Turkey.

Objectives: species have very high medicinal and commercial importance and contain interesting natural substances. However, there is no report on the essential oil or fatty acid composition of any species. This prompted us to investigate the essential oil and fatty acid composition of Schreb. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.49140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227973PMC

Optimization of Immobilized Aldose Reductase Isolated from Bovine Liver.

Turk J Pharm Sci 2019 Jun 27;16(2):206-210. Epub 2019 Mar 27.

Ankara University, Faculty of Science, Department of Biology, Ankara, Turkey.

Objectives: Isolation of enzymes and experiments on them require great effort and cost and are time-consuming. Therefore, it is important to extend the usability of the enzymes by immobilizing them. In this study our purpose was to immobilize the enzyme aldose reductase (AR) and to optimize the experimental conditions of the immobilized AR and compare them to those of free AR. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.81894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227960PMC

Investigation of the Polyphenol Composition, Biological Activities, and Detoxification Properties of Some Medicinal Mushrooms from Turkey.

Turk J Pharm Sci 2019 Jun 27;16(2):155-160. Epub 2019 Mar 27.

Ankara University, Faculty of Science, Department of Biology, Ankara, Turkey.

Objectives: Ethanolic extracts of the mushroom species , and were investigated for their polyphenolic contents and biological activities.

Materials And Methods: The radical scavenging activity of the extracts was evaluated by 2,2-diphenyl-1-(2,4,6-trinitrophenyl) (DPPH) method and their polyphenolic compounds were determined by high performance liquid chromatography (HPLC) analysis. Furthermore, the activity effects of mushroom extracts on the enzyme glutathione-S-transferase (GST) were also examined. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.03274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227972PMC
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