277 results match your criteria Biologie aujourd'hui[Journal]


[Neural circuits and neurotransmitters involved in the effects of psychoactive drugs - State of the art with a focus on cocaine].

Authors:
Florence Noble

Biol Aujourdhui 2019 12;213(3-4):141-145. Epub 2019 Dec 12.

CNRS ERL3649, Inserm U1124, Université Paris Descartes, Pharmacologie et thérapie des addictions, 45 rue des Saints-Pères, 75006 Paris, France.

Addiction is a chronic disease that has serious consequences, both in terms of public health and economy. Clear characteristics distinguish recreational and controlled use from addiction. Thus, today, addiction includes the notions of compulsive drug use, associated with a loss of control over consumption, leading to craving. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019013DOI Listing

[New therapeutic avenues for neurosteroids in psychiatric diseases].

Authors:
Nicolas Froger

Biol Aujourdhui 2019 12;213(3-4):131-140. Epub 2019 Dec 12.

MAPREG SAS, CHU Bicêtre, 94270 Le Kremlin-Bicêtre, France.

Discovered in the eighties by Pr Baulieu and colleagues, neurosteroids are a class of neuroactive brain-born steroids, which comprises the steroid hormones, their biosynthesis precursors and their metabolites. They can act through genomic as well as non-genomic pathways. Genomic pathways, only triggered by the neurosteroid hormones, are, in the brain, the same as those largely described in the periphery: the binding of these steroid hormones to nuclear receptors leads to transcription regulations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019023DOI Listing

[Neurotrophic mechanisms of psychedelic therapy].

Biol Aujourdhui 2019 12;213(3-4):121-129. Epub 2019 Dec 12.

CNRS ERL 3649 « Neuroplasticité et thérapies des addictions », UMR-S 1124, Université Paris Descartes, 4, avenue de l'Observatoire, 75006 Paris, France.

Psychedelic drugs, often referred to as hallucinogens, are quite distinct from other classes of psychotropic drugs. Although the subjective and behavioral effects they induce are quite dramatic, they possess little addictive potential when compared to nicotine, alcohol or opiates. Since the discovery of ketamine antidepressant effects, there has been growing interest for these molecules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019015DOI Listing
May 2020
5 Reads

[PET imaging for better understanding of normal and pathological neurotransmission].

Authors:
Luc Zimmer

Biol Aujourdhui 2019 12;213(3-4):109-120. Epub 2019 Dec 12.

Centre de Recherche en Neurosciences de Lyon (CNRS - INSERM - Université Claude Bernard Lyon 1), Lyon, France - CERMEP-Imagerie du Vivant, Hospices Civils de Lyon, Bron, France - Institut National des Sciences et Techniques Nucléaires, CEA, Saclay, France.

Positron emission tomography imaging is still an expanding field of preclinical and clinical investigations exploring the brain and its normal and pathological functions. In addition to technological improvements in PET scanners, the availability of suitable radiotracers for unexplored pharmacological targets is a key factor in this expansion. Many radiotracers (or radiopharmaceuticals, when administered to humans) have been developed by multidisciplinary teams to visualize and quantify a growing numbers of brain receptors, transporters, enzymes and other targets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019025DOI Listing

[Narcolepsy: From the discovery of a wake promoting peptide to autoimmune T cell biology and molecular mimicry with flu epitopes].

Biol Aujourdhui 2019 12;213(3-4):87-108. Epub 2019 Dec 12.

Stanford Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Medicine, Stanford University, 3615 Porter Drive, Palo Alto, CA, USA.

Narcolepsy-cataplexy was first described in the late 19th century in Germany and France. Prevalence was established to be 0.05 % and a canine model was discovered in the 1970s. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019026DOI Listing

[Michel Jouvet, from the discovery of paradoxical sleep and muscle atonia to the role of neuropeptides].

Biol Aujourdhui 2019 12;213(3-4):81-86. Epub 2019 Dec 12.

Inserm, U1028; CNRS, UMR5292 Lyon Neuroscience Research Center, Team "SLEEP", Faculté de Médecine RTH Laennec, 7, rue Guillaume Paradin, 69372 Lyon cedex 08, France - Université Lyon 1, Lyon, France.

This article focuses on the contributions made by Michel Jouvet about the neurons responsible for generating the muscle atonia of paradoxical sleep (REM sleep). He was the first to describe the neurons responsible for muscle atonia during paradoxical sleep using "pontine" cats (in which the forebrain has been removed down to the pons) and localized pontine lesions. Also discussed is the research going on in the 1980s, when Michel Jouvet was hunting for the hypnogenic factor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019024DOI Listing

Bernard Kerdelhué.

Authors:
William Rostène

Biol Aujourdhui 2019;213(1-2):79-80. Epub 2019 Jul 5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019018DOI Listing
January 2020

Pierre Godeau.

Authors:
Claude Jaffiol

Biol Aujourdhui 2019;213(1-2):77. Epub 2019 Jul 5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019012DOI Listing
January 2020

Georges David.

Authors:
Pierre Jouannet

Biol Aujourdhui 2019;213(1-2):75. Epub 2019 Jul 5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019016DOI Listing
January 2020

Jacques-Paul Borel.

Biol Aujourdhui 2019;213(1-2):73-74. Epub 2019 Jul 5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019017DOI Listing
January 2020
1 Read

[New horizons for acute and prophylactic treatments of migraine].

Authors:
Dominique Valade

Biol Aujourdhui 2019 5;213(1-2):59-64. Epub 2019 Jul 5.

Service de Neurochirurgie, Hôpital Pitié-Salpétrière, 75013 Paris, France.

The current treatment of migraine attacks is triptans and NSAIDs, but the calcitonin gene-related peptide (CGRP) has emerged as a key neuropeptide target for migraine therapy. Despite an off target class effect on liver enzymes, two CGRP receptor antagonists, ubrogepant and rimegepant, remain in development, together with a 5-HT receptor agonist (lasmiditan), for which cardiovascular contraindications that limit the utility of triptans do not exist. Importantly, to avoid an excessive use of acute medication with the risk of medication overuse, prophylactic therapeutics are the best choice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019021DOI Listing
January 2020

[Two-pore-domain potassium channels and molecular mechanisms underlying migraine].

Biol Aujourdhui 2019 5;213(1-2):51-57. Epub 2019 Jul 5.

Université Côte d'Azur, CNRS, INSERM, Institut de Biologie Valrose, Parc Valrose, 06108 Nice, France - Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France.

Migraine is a common, disabling neurological disorder with genetic, environmental and hormonal components and a prevalence estimated at ∼15%. Migraine episodes are notably related, among several factors, to electric hyperexcitability in sensory neurons. Their electrical activity is controlled by ion channels that generate current, specifically by the two-pore-domain potassium, K2P, channels, which inhibit electrical activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019020DOI Listing
January 2020
2 Reads

[Brain network dysfunctions as substrates of primary headaches].

Biol Aujourdhui 2019 5;213(1-2):43-49. Epub 2019 Jul 5.

Institut de Psychiatrie et Neurosciences de Paris (IPNP), Inserm U1261, 102-108, rue de la Santé, 75014 Paris, France.

A large body of clinical and pre-clinical evidence has shown complex interactions between bottom-up and top-down mechanisms that are essential for the discrimination of noxious information and pain perception. These endogenous systems, mainly originating from the brainstem, hypothalamus and cerebral cortex, are strongly influenced by behavioral, cognitive and emotional factors that are relevant for the survival of the individual. Under pathological conditions, however, dysfunctional engagement of these descending pathways certainly contributes to the transformation from acute into chronic pain states. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019022DOI Listing
January 2020
5 Reads

[Migraine epidemiological, clinical and therapeutic data].

Authors:
Caroline Roos

Biol Aujourdhui 2019 5;213(1-2):35-41. Epub 2019 Jul 5.

Centre d'Urgence des Céphalées, AP-HP, Hôpital Lariboisière, 75010 Paris, France.

Burden of disease study ranks headache disorders as the second leading cause of years lived with disability worldwide. Migraine has an estimated prevalence of 10 to 14% and is therefore the most common neurological pathology. It concerns young populations, with a female/male ratio of 3/1, and its impact in economic terms is mainly related to indirect costs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019019DOI Listing
January 2020
2 Reads

[Metamorphosis of marine fish larvae and thyroid hormones].

Biol Aujourdhui 2019 5;213(1-2):27-33. Epub 2019 Jul 5.

Observatoire Océanologique de Banyuls-sur-Mer, UMR CNRS 7232 Biologie Intégrative des Organismes Marins, Sorbonne Université, 1 avenue Pierre Fabre, 66650 Banyuls-sur-Mer, France.

Life history transitions are critical for many animal species and often correspond to concomitant developmental and ecological shifts. However, to date, little is known on how internal and external cues act together during these events. The life cycle of most teleostean reef fish includes a major developmental and ecological transition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019010DOI Listing
January 2020

[Thyroid disruptors and their consequences on brain development and behavior].

Biol Aujourdhui 2019 5;213(1-2):17-26. Epub 2019 Jul 5.

Muséum National d'Histoire Naturelle, CNRS UMR 7221, Laboratoire Physiologie moléculaire de l'adaptation, 7 rue Cuvier, 75005 Paris, France.

An increase in the prevalence of many diseases affecting the nervous system in both children and adults has been reported. Some of these diseases are related to endocrine dysfunction, notably of the thyroid axis. Examples in children are attention deficit/hyperactivity disorders and Autism Spectrum Disorders, diagnosed but most often affecting the whole life, and multiple sclerosis or Alzheimer's disease in adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019009DOI Listing
January 2020

[Thyroid hormones regulate neural stem cell fate].

Biol Aujourdhui 2019 5;213(1-2):7-16. Epub 2019 Jul 5.

Muséum National d'Histoire Naturelle, CNRS UMR 7221, Laboratoire Physiologie moléculaire de l'adaptation, 7 rue Cuvier 75005 Paris, France.

Thyroid hormones (THs) are vital for vertebrate brain function throughout life, from early development to ageing. Epidemiological studies show an adequate supply of maternal TH during pregnancy to be necessary for normal brain development, and this from the first trimester of onwards. Maternal TH deficiency irreversibly affects fetal brain development, increasing the risk of offspring cognitive disorders and IQ loss. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019007DOI Listing
January 2020
2 Reads

[Epidemiology of congenital hypothyroidism in France: recent data].

Authors:
Juliane Léger

Biol Aujourdhui 2019 5;213(1-2):1-5. Epub 2019 Jul 5.

AP-HP, Hôpital Universitaire Robert Debré, Service d'Endocrinologie Diabétologie Pédiatrique, Centre de Référence des Maladies Endocriniennes Rares de la Croissance et du Développement, Unité d'Epidémiologie Clinique, Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR 1141, DHU Protect, 48 boulevard Sérurier, 75019 Paris, France.

Congenital hypothyroidism (CH) is the leading cause of preventable mental retardation. It is mainly due to thyroid dysgenesis or dyshormonogenesis with normally located gland, and detected at birth in developed countries, by mass biochemical screening of newborns. An increase in the incidence of congenital hypothyroidism with a normally located gland has been reported worldwide over the last three decades. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019005DOI Listing
January 2020

Diplôme Mérite et Dévouement Français à la Société de Biologie.

Authors:
William Rostène

Biol Aujourdhui 2018 26;212(1-2):53. Epub 2018 Oct 26.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2018021DOI Listing
April 2019
2 Reads

[Endosomal control of intracellular signaling].

Biol Aujourdhui 2018 26;212(1-2):45-51. Epub 2018 Oct 26.

Institut Curie - Centre de Recherche, PSL Research University, Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, 75248 Paris Cedex 05, France - Institut National de la Santé et de la Recherche Médicale (INSERM), U1143, Paris, France - Centre National de la Recherche Scientifique (CNRS), UMR 3666, Paris, France.

Membrane receptors control essential processes such as cell growth, adhesion, differentiation and metabolism through the activation of specific signaling pathways. Nowadays, these receptors are not only known to signal from the plasma membrane but also from intracellular compartments. Indeed, after being internalized with their ligands via different endocytic pathways, some membrane receptors can initiate signal only after reaching the sorting endosome where they associate with specific protein partners. Read More

View Article

Download full-text PDF

Source
https://www.biologie-journal.org/10.1051/jbio/2018023
Publisher Site
http://dx.doi.org/10.1051/jbio/2018023DOI Listing
April 2019
17 Reads

[Traffic and signalisation of the leptin receptor].

Authors:
Julie Dam

Biol Aujourdhui 2018 26;212(1-2):35-43. Epub 2018 Oct 26.

Institut Cochin, Inserm U1016, CNRS UMR 8104, Université Paris Descartes, Sorbonne Paris Cité, 22 Rue Méchain, 75014 Paris, France.

Receptors are the master regulators conveying the information provided by the hormone from the extracellular environment to the intracellular milieu. As a result, the level of receptors at the cell surface can determine the signaling strength. Regulation of receptor trafficking to the cell surface or receptor retention processes in intracellular compartments are key mechanisms for leptin receptor (ObR) activity. Read More

View Article

Download full-text PDF

Source
https://www.biologie-journal.org/10.1051/jbio/2018020
Publisher Site
http://dx.doi.org/10.1051/jbio/2018020DOI Listing
April 2019
2 Reads

[Nuclear EGFR: a new mode of oncogenic signalling in cancer].

Authors:
Sylvie Gazzeri

Biol Aujourdhui 2018 26;212(1-2):27-33. Epub 2018 Oct 26.

« Epigénétique, maladies chroniques et cancer », INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Institut pour l'Avancée des Biosciences (IAB), Allée des Alpes, 38700 La Tronche Cedex 09, France.

EGFR (Epidermal Growth Factor Receptor) is one of the most studied molecules in biology. From its early identification and cloning to the discovery of its role in cancer, it has been at the forefront of our understanding of Receptor Tyrosine Kinase (RTK) and cell signals that induce homeostasis, but when overexpressed, facilitate tumorigenesis. While the biological functions of EGFR traditionally involve the activation of a signaling network from the plasma membrane that includes activation of the RAS/MAPK/ERK, PI3K/AKT and STATS pathways, a new mode of EGFR signaling has been progressively decoded in which membrane-associated EGFR is transported after endocytosis from cell surface to the nucleus through endocytosis, retrograde trafficking to the Golgi, the endoplasmic reticulum and the inner nuclear membrane through a series of proteic interactions. Read More

View Article

Download full-text PDF

Source
https://www.biologie-journal.org/10.1051/jbio/2018016
Publisher Site
http://dx.doi.org/10.1051/jbio/2018016DOI Listing
April 2019
21 Reads

[Mitochondrial signaling of G protein-coupled receptors].

Biol Aujourdhui 2018 26;212(1-2):21-26. Epub 2018 Oct 26.

Inserm, U1016, Institut Cochin, 22 rue Méchain, 75014 Paris, France - CNRS UMR 8104, Paris, France - Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

G protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with 800 members in humans that are expressed at the cell surface responding to a large panel of extracellular stimuli. Recent advances indicate that GPCRs are also expressed in intracellular compartments where they fulfil important functions. Here, we will report on the mitochondrial localization and function of GPCRs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2018024DOI Listing
April 2019
6 Reads

[Internalized receptor for glucose-dependent insulinotropic peptide stimulates adenylyl cyclase on early endosomes].

Biol Aujourdhui 2018 26;212(1-2):13-19. Epub 2018 Oct 26.

Laboratoire de Physique et Chimie des Nano-objets (LPCNO), équipe RTTC, Université de Toulouse, CNRS, INSA, INSERM, Université Paul Sabatier, 1 avenue Jean Poulhès, 31432 Toulouse cedex, France - INSERM ERL1226, Receptors and Therapeutic Targeting of Cancers, Toulouse, France.

G-protein coupled receptors represent the largest family of membrane receptors. G-protein dependent signal of GPCR is classically thought to originate exclusively from the plasma membrane and, until very recently, internalized GPCRs were considered silent. At present, experimental proofs exist showing that GPCR can continue to signal via G proteins after internalization. Read More

View Article

Download full-text PDF

Source
https://www.biologie-journal.org/10.1051/jbio/2018018
Publisher Site
http://dx.doi.org/10.1051/jbio/2018018DOI Listing
April 2019
27 Reads

[Understanding chronic ocular pain].

Biol Aujourdhui 2018 26;212(1-2):1-11. Epub 2018 Oct 26.

Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.

Dry eye disease (DED) is a common chronic condition with multifactorial etiologies that is increasing in prevalence worldwide, up to 20% in the elderly. The economic burden and impact of DED on vision, quality of life, work productivity, psychological and physical impact of pain, are considerable. Chronic ocular pain is the most common symptom of DED and there is currently no topical ocular analgesic therapy available to treat this debilitating disease. Read More

View Article

Download full-text PDF

Source
https://www.biologie-journal.org/10.1051/jbio/2018017
Publisher Site
http://dx.doi.org/10.1051/jbio/2018017DOI Listing
April 2019
33 Reads

[From sequence variability to structural and functional prediction: modeling of homologous protein families].

Biol Aujourdhui 2017 7;211(3):239-244. Epub 2018 Feb 7.

Sorbonne Universités, UPMC Université Paris 06, CNRS, Biologie Computationnelle et Quantitative, Institut de Biologie Paris Seine, 75005 Paris, France.

Thanks to next-generation sequencing, the number of sequenced genomes grows rapidly, providing in particular ample examples for the sequence variability between homologous proteins. This article discusses data-driven probabilistic sequence models, which are able to extract a multitude of information from sequence data alone, including (i) structural features like residue-residue contacts, which are formed in the folded protein, (ii) protein-protein interaction interfaces and (iii) phenotypic effects of amino-acid substitutions in proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017030DOI Listing
August 2018
1 Read

[Nextflow, an efficient tool to improve computation numerical stability in genomic analysis].

Biol Aujourdhui 2017 7;211(3):233-237. Epub 2018 Feb 7.

Comparative Bioinformatics Group, Bioinformatics and Genomics Programme, Center for Genomic Regulation (CRG), Dr Aiguader, 88, 08003 Barcelona, Spain - Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Reproducing routine bioinformatics analysis is challenging owing to a combination of factors hard to control for. Nextflow is a flow management framework that uses container technology to insure efficient deployment and reproducibility of computational analysis pipelines. Third party pipelines can be ported into Nextflow with minimum re-coding. Read More

View Article

Download full-text PDF

Source
https://www.biologie-journal.org/10.1051/jbio/2017029
Publisher Site
http://dx.doi.org/10.1051/jbio/2017029DOI Listing
August 2018
3 Reads

[IGoR: a tool for learning and simulating the random generation of antigen receptors].

Authors:
Thierry Mora

Biol Aujourdhui 2017 7;211(3):229-231. Epub 2018 Feb 7.

Laboratoire de physique statistique, École Normale Supérieure, CNRS, UPMC et UPD, 24 rue Lhomond, 75005 Paris, France.

Antigen receptors, which form the base of the adaptive immune system, are created stochastically by a DNA editing process called V(D)J recombination. As high-throughput sequencing enables to study the repertoire of these receptors, it is now possible to learn the probabilistic laws of this random process, and to use them to analyse receptors of interest, generate synthetic repertoires to create controls, or aid the identification of receptors that are specific to diseases, with possible applications for medical diagnostics. This article describes how these tasks can be performed using the IGoR software, which can learn statistical models from data, annotate existing sequences, or generate new synthetic ones with the same laws as the recombination process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017033DOI Listing
August 2018
3 Reads

[Protein-protein interacting networks, their structures and disease-related mutations].

Biol Aujourdhui 2017 7;211(3):223-228. Epub 2018 Feb 7.

Randall Division of Cellular and Molecular Biology, King's College, London, UK.

In recent years, the comparison of protein interactomes has identified conserved modules, that could represent functional nuclei with a common ancestry. Within this context, recent analyses of protein-protein interacting networks have led to a debate on the influence of the experimental method on the quality and biological pertinence of these data. It is crucial to understand the measure in which divergence between networks of different species reflect sampling biases in respective experimental methods, as opposed to topological features dictated by biological functionality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017031DOI Listing
August 2018
1 Read

[Stretch-induced axon growth: a universal, yet poorly explored process].

Biol Aujourdhui 2017 7;211(3):215-222. Epub 2018 Feb 7.

Institut de Biologie Paris-Seine (IBPS), Laboratoire de Biologie du Développement, CNRS UMR7622, INSERM U1156, 75005 Paris, France - Sorbonne Universités, UPMC Université Paris 06, 75005 Paris, France.

The growth of axons is a key step in neuronal circuit assembly. The axon starts elongating with the migration of its growth cone in response to molecular signals present in the surrounding embryonic tissues. Following the formation of a synapse between the axon and the target cell, the distance which separates the cell body from the synapse continues to increase to accommodate the growth of the organism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017028DOI Listing
August 2018
2 Reads

[CRISPR-Cas9, germinal cells and human embryo].

Authors:
Pierre Jouannet

Biol Aujourdhui 2017 7;211(3):207-213. Epub 2018 Feb 7.

Université Paris Descartes, 12 Rue de l'École de Médecine, 75006 Paris, France.

The performance of the molecular tool using CRISPR-Cas9, which makes it possible to induce targeted modifications of the DNA, has found numerous applications in research and open promising prospects in human clinic. CRISPR-Cas9 has been widely used to generate transgenic animals after targeted modification of the genome at the zygotic stage. It was also tested on human embryos on an experimental basis. Read More

View Article

Download full-text PDF

Source
https://www.biologie-journal.org/10.1051/jbio/2017032
Publisher Site
http://dx.doi.org/10.1051/jbio/2017032DOI Listing
August 2018
4 Reads

[Usefulness of CGH-array and SNP-array for the etiological diagnosis of premature ovarian insufficiency].

Authors:
Capucine Hyon

Biol Aujourdhui 2017 7;211(3):199-205. Epub 2018 Feb 7.

AP-HP, GHUEP, Hôpital Armand Trousseau, Département de Génétique Médicale, Paris, France - INSERM, UMRS 933, Hôpital Armand Trousseau, Paris, France - Sorbonne Universités, UPMC Univ Paris 06, Paris, France.

Premature ovarian insufficiency (POI) defined by the cessation of ovarian function before the age of 40 years and the increase of gonadotropins (> 25 UI/l) occurs in approximately 1-5% of women. Different mechanisms are responsible for POI: chemotherapy, radiotherapy, environmental factors or genetic causes but most frequently no cause is identified. In order to determine the etiology of POI, cytogenetic analyses such as karyotype are performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017025DOI Listing
August 2018
1 Read

[Next-generation vector control].

Biol Aujourdhui 2018 11;212(3-4):137-145. Epub 2019 Apr 11.

MIVEGEC (Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle), UMR IRD-CNRS-Université de Montpellier, 911 avenue Agropolis, 34080 Montpellier, France.

Vector control is a cornerstone of vector-borne infectious disease control, a group of emerging and re-emerging diseases of major public health concern at a global scale. The history and evolution of mosquito disease vectors control, mainly based on the use of chemical insecticides, is emblematic of the successes, failures, lessons learned and experiences gained in setting-up and implementing vector control, and of the challenges that pave the way to sustainable disease vector management. This paper provides a non-exhaustive and non-exclusive overview of some of the most promising cutting-edge technical and strategic innovations that are committed to this endeavour, assessing the strength of scientific evidences for proof of concept, perspectives for scaling-up, and expected impact and outcomes in a rapidly changing world. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019006DOI Listing
August 2019
2 Reads

[Mosquito microbiota and its influence on disease vectorial transmission].

Biol Aujourdhui 2018 11;212(3-4):119-136. Epub 2019 Apr 11.

Groupe « Microbiote des Insectes Vecteurs », Institut Pasteur de la Guyane, Cayenne, Guyane, France - Département « Parasites et Insectes Vecteurs », Institut Pasteur, Paris, France.

Mosquitoes (Diptera: Culicidae) are found worldwide. Around 100 among 3500 mosquito species are known to be vectors of parasites and viruses, responsible for infectious diseases including malaria and dengue. Mosquitoes host diverse microbial communities that influence disease transmission, either by direct interference or via affecting host immunity and physiology. Read More

View Article

Download full-text PDF

Source
https://www.biologie-journal.org/10.1051/jbio/2019003
Publisher Site
http://dx.doi.org/10.1051/jbio/2019003DOI Listing
August 2019
14 Reads

[Immunomodulatory effect of tick saliva in pathogen transmission].

Biol Aujourdhui 2018 11;212(3-4):107-117. Epub 2019 Apr 11.

EA7290, Virulence Bactérienne Précoce, Groupe Borrelia, Facultés de Pharmacie et Médecine, Université de Strasbourg, Institut de bactériologie, 3 rue Koeberlé, 67000 Strasbourg, France - Centre National de Référence Borrelia, Plateau technique de Microbiologie, CHRU Strasbourg, 1 rue Koeberlé, 67000 Strasbourg, France.

Ticks are the most important vectors of pathogens in human and veterinary medicine. These strictly haematophagous acarines produce a saliva containing a variety of bioactive molecules affecting host pharmacology and immunity. This process is vital for hard ticks to prevent rejection by the host during the blood meal that lasts several days. Read More

View Article

Download full-text PDF

Source
https://www.biologie-journal.org/10.1051/jbio/2019001
Publisher Site
http://dx.doi.org/10.1051/jbio/2019001DOI Listing
August 2019
2 Reads

[Insects: An exceptional reservoir for viruses and antiviral genes].

Biol Aujourdhui 2018 11;212(3-4):101-106. Epub 2019 Apr 11.

CNRS UPR9022, INSERM U1257, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 15, rue René Descartes, 67084 Strasbourg, France.

Insects are the most diverse group of animals. They can be infected by an extraordinary diversity of viruses. Among them, arthropod-borne viruses (arboviruses) can be transmitted to humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019008DOI Listing
August 2019
3 Reads

[Mosquitoes as vectors of arboviruses: an endless story].

Biol Aujourdhui 2018 11;212(3-4):89-99. Epub 2019 Apr 11.

Institut Pasteur, Département de Virologie, Arbovirus et Insectes Vecteurs, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.

The recent emergence or re-emergence of vector-borne diseases (VBD) and, more specifically, VBD associated with arboviruses such as dengue, chikungunya, Zika or yellow fever are not new events. The globalization of trade and travels as well as the unplanned urbanization of many tropical and subtropical cities have created the conditions suitable for the establishment of vector mosquitoes offering opportunities for arbovirus introduction. This review describes the major arboviruses important for human health and their epidemic vectors, and the conditions leading to their emergence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2018026DOI Listing
August 2019
2 Reads

[Treatment of the advanced HCC: A second revolution by using immunotherapy].

Biol Aujourdhui 2018 11;212(3-4):85-87. Epub 2019 Apr 11.

Service d'Hépato-Gastro-Entérologie, Hôpital de la Pitié-Salpêtrière, 83 boulevard de l'Hôpital, 75013, Paris, France.

The treatment of advanced hepatocellular carcinoma has long been hopeless due to an absence of effective molecules and an underlying cirrhosis, compromising tolerance to conventional chemotherapy. A targeted anti-angiogenic therapy, sorafenib, has been the only option for a decade before new oral molecules have been finally validated. Immunotherapy, intended to correct the immunosuppressive context frequently associated with this tumor, has shown very promising results and could profoundly challenge the therapeutic algorithm of advanced hepatocellular carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2018027DOI Listing
August 2019
3 Reads

[Immunotherapy and bladder cancer].

Biol Aujourdhui 2018 11;212(3-4):81-84. Epub 2019 Apr 11.

Service d'Urologie, Sorbonne Université, GRC n° 5, ONCOTYPE-URO, AP-HP, Hôpital Pitié-Salpêtrière, 83 Boulevard de l'Hôpital, 75013 Paris, France.

Immunotherapy as a treatment of solid malignancy is based on the activation of the immune system against tumor cells. Since 1976, intravesical instillation of Bacillus Calmette-Guérin (BCG) has been used widely for the treatment of non muscle invasive bladder cancer and is nowadays recommended by all scientific guidelines. New targeted systemic immunotherapies and particularly checkpoints inhibitors are now widely used in several different cancers and notably in onco-urology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2018028DOI Listing
August 2019
18 Reads

[Combinations of chemotherapy or radiotherapy with checkpoint inhibitors].

Biol Aujourdhui 2018 11;212(3-4):77-79. Epub 2019 Apr 11.

Université de Bourgogne Franche-Comté, Dijon, France - Centre Georges-François Leclerc, Département d'Oncologie Médicale, 1 rue Pr Marion, BP77980, 21079 Dijon, France - INSERM LNC U1231, Dijon, France.

Recent advances in cancer immunotherapy with the development of anti-PD1/PD-L1 antibodies are revolutionizing cancer care. Nevertheless, the efficacy of these treatments in monotherapy is limited to a subpopulation representing about 25-30% of patients in most indications. The development of new strategies is based on combinations between standard treatments (cytotoxic chemotherapy and radiotherapy) and immunotherapy in order to find synergistic combinations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019004DOI Listing
August 2019
3 Reads

[Anti-cancer vaccines: What future in anti-cancer immunotherapy strategies?]

Authors:
Eric Tartour

Biol Aujourdhui 2018 11;212(3-4):69-76. Epub 2019 Apr 11.

Inserm U970 PARCC, Université Paris Descartes, Hôpital européen Georges-Pompidou, Service d'immunologie biologique, 20, rue Leblanc, 75015 Paris, France.

Tumor cells can be recognized by the immune system and in particular by cytotoxic CD8T cells. From this observation was derived the concept that vaccination targeting these tumor-associated molecules was feasible. Preventive cancer vaccines targeting oncogenic papillomavirus or hepatitis B virus do exist and are efficient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019002DOI Listing
August 2019
1 Read

[New frontiers in the fight against cancer].

Biol Aujourdhui 2018 11;212(3-4):61-67. Epub 2019 Apr 11.

Innate Pharma Research Labs, Innate Pharma, 117 avenue de Luminy, 13009 Marseille, France - Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France - Service d'Immunologie, Marseille Immunopôle, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, 278 rue Saint-Pierre, 13005 Marseille, France.

After many years of research, recent advances shed a new light on the role of the immune system in cancer. New therapeutic antibodies, such as anti-PD-1/L1, that block the interactions of inhibitory receptors (immune checkpoint inhibitors, ICI) with their ligands, have revolutionized the management of cancer patients. Nevertheless, they only affect a small part of the patient population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2019011DOI Listing
August 2019
2 Reads

[Circadian proteomics].

Biol Aujourdhui 2018 11;212(3-4):55-59. Epub 2019 Apr 11.

Institut de Bioingénierie, Faculté des Sciences de la Vie, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Suisse - Département de Pharmacologie et Toxicologie, Université de Lausanne, 1005 Lausanne, Suisse.

Recent development in the proteomic technologies offers new perspectives in circadian biology and in particular the possibility to study post-translational modifications such as phosphorylation and acetylation. Applying in vivo proteomics on whole liver or on nuclear extracts, we were able to characterize the rhythmic liver proteome with unprecedented coverage. It allows the characterization of new rhythmic processes such as protein secretion, ribosome biogenesis, DNA repair, and polyploidy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2018025DOI Listing
August 2019
2 Reads

Note de correction : Le déterminisme du sexe chez les cucurbitacées.

Biol Aujourdhui 2017 13;211(2):197. Epub 2017 Dec 13.

Inra-CNRS, UMR 1165, Unité de Recherche en Génomique Végétale, 91057 Évry cedex, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017017DOI Listing
December 2017
5 Reads

[Insulinoresistancy in Man: from mechanisms to nutritional interference].

Authors:
Ariane Sultan

Biol Aujourdhui 2017 13;211(2):189-196. Epub 2017 Dec 13.

Équipe Nutrition-Diabète, CHU Montpellier, Montpellier, France - PHYMEDEXP INSERM U1046, CNRS UMR9214, Université de Montpellier, Montpellier, France.

Obesity is presently regarded as the "the first non-infectious epidemic outbreak" in the history of Humanity. It is a multifactorial pathology, that contributes to the emergence of insulinoresistancy. Some obese individuals display an obesity qualified as metabolically sound, i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017026DOI Listing
October 2018
6 Reads

[Optically dissecting brain nicotinic receptor function with photo-controllable designer receptors].

Biol Aujourdhui 2017 13;211(2):173-188. Epub 2017 Dec 13.

Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005 Paris, France.

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels widely expressed in the central nervous system and the periphery. They play an important modulatory role in learning, memory and attention, and have been implicated in various diseases such as Alzheimer's disease, Parkinson's disease, epilepsy, schizophrenia and addiction. These receptors are activated by the endogenous neurotransmitter acetylcholine, or by nicotine, the alkaloid found in tobacco leaves. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017022DOI Listing
October 2018
5 Reads

[Claude Bernard and nicotinic receptors: from the neuromuscular junction to tobacco weaning].

Biol Aujourdhui 2017 13;211(2):169-172. Epub 2017 Dec 13.

Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Fédération de Médecine Translationnelle, Université et CHU de Strasbourg, 11 rue Humann, 67085 Strasbourg, France.

Claude Bernard (1813-1878) was fascinated by the pharmacological mechanisms of poisons. In particular, using a huge amount of ingenious and robust experiments, he demonstrated the peripheral toxic action of the natural compound curare. His work generated controversies in a period where scientific methodology and technical development followed the progression of concepts and ideas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017024DOI Listing
October 2018
2 Reads

[Diabetes: What are the key targets and the objectives? Preserving and protecting a functional pancreatic beta cell mass].

Authors:
Stéphane Dalle

Biol Aujourdhui 2017 13;211(2):165-168. Epub 2017 Dec 13.

Institut de Génomique Fonctionnelle, Inserm U1191, UMR CNRS 5203, Université de Montpellier, 141 rue de la Cardonille, 34094 Montpellier, France.

Diabetes is characterized by chronic hyperglycemia. Type 2 diabetes, which represents 90% of diabetes cases, is the consequence of an insulin resistance and pancreatic beta cell dysfunction combination. Since the beta cells are the only cells of the organism to synthesize and to secrete insulin, it is essential to maintain and to protect their function and survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017018DOI Listing
October 2018
7 Reads

[Louis Pasteur and Claude Bernard: about a posthumous controversy].

Authors:
Patrice Debré

Biol Aujourdhui 2017 13;211(2):161-164. Epub 2017 Dec 13.

Département d'immunologie, CIMI Paris, UPMC/INSERM, U1135, hôpital Pitié-Salpêtrière, bâtiment CERVI, 83 boulevard de l'Hôpital, 75013 Paris, France.

Claude Bernard and Louis Pasteur will meet on various occasions, scientific prizes were awarded by Claude Bernard to Louis Pasteur, Claude Bernard's lessons were followed by Louis Pasteur at the Faculty of Science or at the College de France, and friendly relationship were established. But the essential lies in a posthumous controversy where Claude Bernard, denying the role of microbes in the fermentation, seems to criticize Pasteur's assertions and, later, his method and vision. We shall report here the exchanges which concern these two scientists and, beyond that, the scientific approach. Read More

View Article

Download full-text PDF

Source
http://www.biologie-journal.org/10.1051/jbio/2017019
Publisher Site
http://dx.doi.org/10.1051/jbio/2017019DOI Listing
October 2018
8 Reads

[Claude Bernard - then and now].

Authors:
Peter Wise

Biol Aujourdhui 2017 13;211(2):157-160. Epub 2017 Dec 13.

Department of Endocrinology, Charing Cross Hospital and Imperial College School of Medicine, Londres, Royaume-Uni.

The early life of Claude Bernard - dreamer and frustrated playwright - reveals no indication of his future scientific aptitude. Cartesian doubt, a principle that he would adhere to lifelong, clouded a failed pharmacy apprenticeship that led to medical studies in Paris - but without great success. Research was his only aim, it was made possible only by a lucrative but unsuccessful arranged marriage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/jbio/2017023DOI Listing
October 2018
6 Reads