591,888 results match your criteria Biologics in Therapy [Journal]


Pediatric Dermatology - critical approach to the new treatments.

Dermatol Ther 2018 Dec 7:e12801. Epub 2018 Dec 7.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health.

The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. Read More

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December 2018
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Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers.

Chem Rec 2018 Dec 10. Epub 2018 Dec 10.

Epigenetic Chemical Biology, Institut Pasteur, CNRS UMR3523, 28 rue du Docteur Roux, 75724, Paris cedex 15, France.

DNA methylation and histone acetylation are widely studied epigenetic modifications. They are involved in numerous pathologies such as cancer, neurological disease, inflammation, obesity, etc. Since the discovery of the epigenome, numerous compounds have been developed to reverse DNA methylation and histone acetylation aberrant profile in diseases. Read More

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December 2018

Anti-proliferative and anti-malarial activities of spiroisoxazoline analogues of artemisinin.

Arch Pharm (Weinheim) 2018 Dec 10:e1800192. Epub 2018 Dec 10.

Department of Chemistry, School of Chemical and Life Science, Jamia Hamdard, New Delhi, India.

A series of spiroisoxazoline analogues of artemisinin was synthesized by employing 1,3-dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All the synthesized compounds were tested for their anti-proliferative and anti-malarial activities. Among the compounds tested, compound 11a was found to be potent against the HCT-15 cancer cell line with IC  = 4. Read More

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December 2018
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Bioaccessibility of carotenoids from plant and animal foods.

J Sci Food Agric 2018 Dec 7. Epub 2018 Dec 7.

Institute of Food Science and Biotechnology, Chair Plant Foodstuff Technology and Analysis, University of Hohenheim, Garbenstrasse 25, D-70599 Stuttgart, Germany.

The frequent consumption of carotenoid-rich foods has been associated with numerous health benefits such as the supply of provitamin A. In order to exert these health benefits, carotenoids need to be efficiently liberated from the food matrix, micellized in the small intestine, taken up by the enterocytes, and absorbed to the human blood stream. Enormous efforts have been made to better understand these processes. Read More

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December 2018

RhoB antibody alters retinal vascularization in models of murine retinopathy.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

Neovascularization in cancer or retinopathy is driven by pathological changes that foster abnormal sprouting of endothelial cells. Mouse genetic studies indicate that the stress-induced small GTPase RhoB is dispensable for normal physiology but required for pathogenic angiogenesis. In diabetic retinopathy, retinopathy of prematurity (ROP) or age-related wet macular degeneration (AMD), progressive pathologic anatomic changes and ischemia foster neovascularization are characterized by abnormal sprouting of endothelial cells. Read More

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December 2018

Synthesis and biological evaluation of substituted indole and its analogs as influenza A virus inhibitors.

Chem Biodivers 2018 Dec 9. Epub 2018 Dec 9.

: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China, CHINA.

Influenza A virus (IAV), a highly pathogenic virus to human beings, is most susceptible to mutation and thus causes rapid, severe global pandemics resulting in millions of fatalities worldwide. Since resistance to the existing anti-influenza drugs is developing, innovative inhibitors with a different mode of action are urgently needed. The lead compound 6092B-E5 has proven to be an effective antiviral reagent in our previous work. Read More

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December 2018

Assuring immune globulin potency in a world of changing pathogen challenges.

Authors:
Dorothy E Scott

Transfusion 2018 Dec;58 Suppl 3:3121-3124

Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.

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December 2018

Immune globulin potency: challenges and opportunities.

Authors:
Dorothy E Scott

Transfusion 2018 Dec;58 Suppl 3:3051-3053

Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.

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December 2018

Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance.

Pharm Res 2018 Dec 10;36(1):24. Epub 2018 Dec 10.

Biologics Development, Bristol-Myers Squibb, 311 Pennington Rocky Hill Road, Pennington, NJ, 08534, USA.

Purpose: Tryptophan's (Trp) unique hydrophobic and structural properties make it an important antigen binding motif when positioned in complementarity-determining regions (CDRs) of monoclonal antibodies (mAbs). Oxidation of Trp residues within the CDR can deleteriously impact antigen binding, particularly if the CDR conformation is altered. The goal of this study was to evaluate the conformational and functional impact of Trp oxidation for two mAb subtypes, which is essential in determining the structure-function relationship and establishing appropriate analytical control strategies during protein therapeutics development. Read More

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December 2018

Surgical outcomes of patients treated with ustekinumab vs. vedolizumab in inflammatory bowel disease: a matched case analysis.

Int J Colorectal Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Colorectal Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.

Aim: The association between preoperative use of monoclonal antibodies in inflammatory bowel disease (IBD) patients and postoperative complications is controversial, especially for the latest approved biologics, ustekinumab and vedolizumab, where data is limited. We hypothesized that ustekinumab-treated patients would have a similar overall postoperative complication rate as vedolizumab-treated patients. The aim of this study was to compare postoperative complications in patients receiving preoperative ustekinumab vs. Read More

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December 2018

Genome of the small hive beetle (Aethina tumida, Coleoptera: Nitidulidae), a worldwide parasite of social bee colonies, provides insights into detoxification and herbivory.

Gigascience 2018 Dec 7. Epub 2018 Dec 7.

Institute of Bee Health, Vetsuisse Faculty, University of Bern, Schwarzenburgstrasse 161, CH-3097, Liebefeld, Switzerland.

Background: The small hive beetle (Aethina tumida, ATUMI) is an invasive parasite of bee colonies. ATUMI feeds on both fruits and bee nest products, facilitating its spread and increasing its impact on honey bees and other pollinators. We have sequenced and annotated the ATUMI genome, providing the first genomic resources for this species and for the Nitidulidae, a beetle family that is closely related to the extraordinarily species-rich clade of beetles known as the Phytophaga. Read More

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December 2018

The Qualified Presumption of Safety assessment and its role in EFSA risk evaluations: fifteen years past.

FEMS Microbiol Lett 2018 Dec 10. Epub 2018 Dec 10.

Unit of Biological Hazards and Contaminants (BIOCONTAM), European Food Safety Authority (EFSA), via Carlo Magno 1A, 43126 Parma, Italy.

Microorganisms (food or feed additive, novel food or plant protection product) are intentionally added at different stages of the food and feed chain and are subjected to regulation and safety assessment by the European Food Safety Authority (EFSA). Safety evaluation is based on application dossiers for market authorisation to the European Commission. The qualified presumption of safety (QPS) concept was developed in 2003 to provide a harmonised generic safety pre-appraisal of the above microorganisms. Read More

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December 2018

Decoding the Ocean's Microbiological Secrets for Marine Enzyme Biodiscovery.

FEMS Microbiol Lett 2018 Dec 5. Epub 2018 Dec 5.

School of Natural Sciences, Bangor University, Bangor, LL57 2UW, United Kingdom.

A global census of marine microbial life has been underway for several decades. During this time there have been scientific breakthroughs in estimating microbial diversity and understanding microbial functioning and ecology. It is estimated that the ocean, covering 71% of the earth's surface with its estimated volume of about 2 × 1018 m3 and an average depth of 3800 m, hosts the largest population of microbes on Earth. Read More

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December 2018

Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques.

ESCAPE 2018 4;43:421-426. Epub 2018 Jul 4.

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, 77843, USA.

The ultimate goal of the Texas A&M Superfund program is to develop comprehensive tools and models for addressing exposure to chemical mixtures during environmental emergency-related contamination events. With that goal, we aim to design a framework for optimal grouping of chemical mixtures based on their chemical characteristics and bioactivity properties, and facilitate comparative assessment of their human health impacts through read-across. The optimal clustering of the chemical mixtures guides the selection of sorption material in such a way that the adverse health effects of each group are mitigated. Read More

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Leptin Functions in Infectious Diseases.

Front Immunol 2018 26;9:2741. Epub 2018 Nov 26.

Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

Leptin, a pleiotropic protein has long been recognized to play an important role in the regulation of energy homeostasis, metabolism, neuroendocrine function, and other physiological functions through its effects on the central nervous system (CNS) and peripheral tissues. Leptin is secreted by adipose tissue and encoded by the obese () gene. Leptin acts as a central mediator which regulates immunity as well as nutrition. Read More

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November 2018

Exploratory evaluation of pharmacodynamics, pharmacokinetics and safety of rivaroxaban in children and adolescents: an EINSTEIN-Jr phase I study.

Thromb J 2018 4;16:31. Epub 2018 Dec 4.

11Clinical Development, Bayer AG, Pharmaceuticals, Wuppertal, Germany.

Background: The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults.

Methods: This was a multinational, single-dose, open-label, phase I study to describe the pharmacodynamics (PD), pharmacokinetics (PK) and safety of a single bodyweight-adjusted rivaroxaban dose in children aged 0.5-18 years. Read More

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December 2018

Genomic Alterations of Staphylococcus aureus ATCC 25923 after Prolonged Passage in the Laboratory.

Microbiol Resour Announc 2018 Nov 8;7(18). Epub 2018 Nov 8.

Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Staphylococcus aureus reference strain ATCC 25923 has been maintained for more than a decade in our laboratory. Genomic study revealed that the resulting strain AFIPCBER_B_8.4 has lost a 37-kb genomic fragment of the ATCC 25923 parental strain. Read More

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November 2018

Synthesis, Purification, and Mass Spectrometric Characterization of Stable Isotope-Labeled Amadori-Glycated Phospholipids.

ACS Omega 2018 Nov 19;3(11):15725-15733. Epub 2018 Nov 19.

Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina 28081, United States.

Nonenzymatic glycation of lipids plays an important role in several physiological and pathological processes, such as normal aging and complications of diabetes mellitus. To develop liquid chromatography coupled with mass spectrometric (LC-MS) methods for accurate analysis of Amadori compound-glycated lipids from biological samples, it is essential to obtain isotope-labeled Amadori-lipid standards. Herein, we report optimized methods for the preparation of six stable isotope-labeled Amadori-glycated lipid standards covering four types of lipids, including [C]Amadori-phosphatidyl ethanolamine (PE), -phosphatidyl serine (PS), -LysoPE, and -LysoPS. Read More

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November 2018

Protective Role of Nuclear Factor-Erythroid 2-Related Factor 2 Against Radiation-Induced Lung Injury and Inflammation.

Front Oncol 2018 23;8:542. Epub 2018 Nov 23.

Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University, Wuhan, China.

Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy. Inflammatory cell infiltration, imbalance of inflammatory cytokines, and oxidative damage were reported to be involved during RILI pathogenesis, especially in the early phase of RILI. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator of antioxidative cascades, and regulates life span of mice after administration of thoracic irradiation. Read More

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November 2018

Analysis of bone osteometry, mineralization, mechanical and histomorphometrical properties of tibiotarsus in broiler chickens demonstrates a influence of dietary chickpea seeds (Cicer arietinum L.) inclusion as a primary protein source.

PLoS One 2018 11;13(12):e0208921. Epub 2018 Dec 11.

Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.

This study was focused on analyzing the effects of dietary inclusion of raw chickpea seed as a replacement of soybean meal as a primary protein source on bone structure in broiler chickens. Broiler chickens (n = 160) received in their diet either soybean meal (SBM) or raw chickpea seeds (CPS) as a primary protein source throughout the whole rearing period (n = 80 in each group). On the 42th day randomly selected chickens from each group (n = 8) were slaughtered. Read More

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December 2018

and Spore Inactivation by Low Energy Electron Beam Technology: Resistance and Influencing Factors.

Front Microbiol 2018 23;9:2720. Epub 2018 Nov 23.

Sustainable Food Processing Laboratory, Institute of Food, Nutrition and Health, Department of Health Science and Technology, ETH Zurich, Zurich, Switzerland.

Low energy electron beam (LEEB) treatment is an emerging non-thermal technology that performs surface decontamination with a minimal influence on food quality. Bacterial spore resistance toward LEEB treatment and its influencing factors were investigated in this study. Spores from and species were treated with a lab-scale LEEB at energy levels of 80 and 200 keV. Read More

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November 2018

Genetic resistance of eight native Egyptian chicken breeds having chicken B-cell marker 6 gene post-challenge with field strain of Marek's disease-induced tumor virus.

Vet World 2018 Nov 29;11(10):1510-1515. Epub 2018 Oct 29.

Department of Virology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Aim: The aim of this work was to detect chicken B-cell marker 6 () gene in some native breeds in Egypt and find the relationship between founded genes in these different breeds to determine the resistance of native Egyptian breeds of chicken to Marek's disease (MD).

Materials And Methods: A total of 14 different chicken breeds (30 each) including ten native breeds in addition to SPF Lohmann, High Line, Bovans, and Roodiland were used. Blood samples were collected for the detection of () by polymerase chain reaction (PCR) assay and sequenced to determine the presence or absence of 6 gene. Read More

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November 2018

GC-MS application in determination of volatile profiles emitted by infected and uninfected human tissue.

J Breath Res 2018 Dec 7. Epub 2018 Dec 7.

Nicolaus Copernicus University, Torun, POLAND.

Volatile organic compounds (VOCs) released into the headspace air over human tissues infected with different bacteria were investigated in this work. The above-mentioned VOCs result both from bacterial metabolic processes (pathogen-specific signals) and from the matrix (tissue samples themselves). The objective of this study was to investigate whether one could reliably identify various microorganism strains that exist inside infected tissue samples by direct monitoring of the headspace atmosphere above their cultures. Read More

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December 2018

Apoptosis and apoptotic body: disease message and therapeutic target potentials.

Biosci Rep 2018 Dec 7. Epub 2018 Dec 7.

Nanjing University, nanjing, China

Apoptosis is widely known as programmed cell death eliciting no inflammatory responses. The intricacy of apoptosis has been a focus of an array of researches, accumulating a wealth of knowledge which led to not only a better understanding of the fundamental process, but also potent therapeutic measures of diseases. The classic intrinsic and extrinsic signaling pathways of apoptosis, along with regulatory factors have been well delineated. Read More

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December 2018

Genomic and phenotypic diversity among ten laboratory isolates of PAO1.

J Bacteriol 2018 Dec 10. Epub 2018 Dec 10.

Department of Microbial Pathogenesis, University of Maryland - Baltimore, Baltimore, MD, 21201.

is an opportunistic pathogen, found ubiquitously in the environment and commonly associated with airway infection in patients with cystic fibrosis. strain PAO1 is one of the most commonly used laboratory-adapted research strains and is a standard laboratory-adapted strain in multiple laboratories and strain banks worldwide. Due to potential isolate-to-isolate variability, we investigated the genomic and phenotypic diversity among ten PAO1 strains (henceforth called sublines) obtained from multiple research laboratories and commercial sources. Read More

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December 2018

Development and evaluation of a WeChat-based life review programme for patients with cancer: protocol for a randomised controlled trial.

BMJ Open 2018 Dec 6;8(12):e020239. Epub 2018 Dec 6.

School of Nursing, Fujian Medical University, Fuzhou, China.

Introduction: Patients with cancer often suffer from considerable distress. Life review is a process of recalling, evaluating and integrating life experiences to alleviate a sense of despair and achieve self-integrity. Empirical data have supported the fact that life review is an effective psychological intervention, but it is not always accessible to patients with cancer. Read More

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December 2018

Understanding Protein Networks using Vester's Sensitivity Model.

IEEE/ACM Trans Comput Biol Bioinform 2018 Dec 10. Epub 2018 Dec 10.

Magnesium-based biomaterials belong to the third generation of biomaterials that are also bioactive. These smart materials combine bioactivity and biodegradability, and elicit specific cellular responses at the molecular level. In fact, osteoinductive properties have been observed in mesenchymal stem cells in the presence of Magnesium. Read More

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December 2018

Transforming phosphorus use on the island of Ireland: A model for a sustainable system.

Sci Total Environ 2018 Nov 29;656:852-861. Epub 2018 Nov 29.

School of Biological Sciences and the Institute for Global Food Security, The Queen's University of Belfast, United Kingdom.

Phosphorus is an essential part of the world food web and a non-substitutable nutrient in all biological systems. Losses of phosphorus occur along the food-supply chain and cause environmental degradation and eutrophication. A key global challenge is to meet rising worldwide food demand while protecting water and environmental quality, and seeking to manage uncertainty around potential future phosphorus price or supply shocks. Read More

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November 2018

Perspectives on defining cell types in the brain.

Curr Opin Neurobiol 2018 Dec 6;56:61-68. Epub 2018 Dec 6.

Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, QB3 Functional Genomics Laboratory, University of California, Berkeley, CA 94720, United States. Electronic address:

The diversity of brain cell types was one of the earliest observations in modern neuroscience and continues to be one of the central concerns of current neuroscience research. Despite impressive recent progress, including single cell transcriptome and epigenome profiling as well as anatomical methods, we still lack a complete census or taxonomy of brain cell types. We argue this is due partly to the conceptual difficulty in defining a cell type. Read More

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December 2018

Multi-target inhibitors against Alzheimer disease derived from 3-hydrazinyl 1,2,4-triazine scaffold containing pendant phenoxy methyl-1,2,3-triazole: Design, synthesis and biological evaluation.

Bioorg Chem 2018 Nov 29;84:363-371. Epub 2018 Nov 29.

Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Alzheimer's disease (AD) is a complex neurological disorder with diverse underlying pathological processes. Several lines of evidence suggest that BACE1 is a key enzyme in the pathogenesis of AD and its inhibition is of particular importance in AD treatment. Ten new 3-hydrazinyl-1,2,4-triazines bearing pendant aryl phenoxy methyl-1,2,3-triazole were synthesized as multifunctional ligands against AD. Read More

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November 2018

Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes.

J Colloid Interface Sci 2018 Dec 3;538:404-419. Epub 2018 Dec 3.

Department of Pharmacy, University of Copenhagen, DK-2100 Copenhagen, Denmark; Department of Pharmacy, University of Uppsala, SE-75123 Uppsala, Sweden. Electronic address:

The exposure of biological membranes to reactive oxygen species (ROS) plays an important role in many pathological conditions such as inflammation, infection, or sepsis. ROS also modulate signaling processes and produce markers for damaged tissue. Lipid peroxidation, mainly affecting polyunsaturated phospholipids, results in a complex mixture of oxidized products, which may dramatically alter membrane properties. Read More

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December 2018
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Clotrimazole multiple W/O/W emulsion as anticandidal agent: Characterization and evaluation on skin and mucosae.

Colloids Surf B Biointerfaces 2018 Nov 29;175:166-174. Epub 2018 Nov 29.

Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, University Campus of Cartuja, 18071 Granada, Spain; Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, 645 Diagonal Ave., 08028 Barcelona, Spain. Electronic address:

Clotrimazole (CLT) was formulated in a multiple W/O/W emulsion (ME) with the aim of evaluating its potential as topical anticandidal agent and comparing with marketed products. A previously evaluated CLT-ME was selected and physicochemically characterized. The in vitro release behavior and the ex vivo permeation profiles were assessed using Franz diffusion cells using three different types of biological membranes: human skin and porcine buccal, sublingual and vaginal mucosae. Read More

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November 2018

Assessment of silt from sand and gravel processing as a suitable sub-soil material in land restoration: A glasshouse study.

Chemosphere 2018 Dec 1;219:58-65. Epub 2018 Dec 1.

School of Water, Energy and Environment, Cranfield University, Building 52a, Cranfield Bedfordshire, MK43 0AL, UK. Electronic address:

Annually, sand and gravel processing generates approximately 20 million tonnes of non-commercial by-product as fine silt particles (<63 μm) which constitutes approximately 20% of quarry production in the UK. This study is significant as it investigated the use of quarry silt as a sub-soil medium to partially substitute soil-forming materials whilst facilitating successful post-restoration crop establishment. In a glasshouse pot experiment, top-soil and sub-soil layering was simulated, generating an artificial sub-soil medium by mixing two quarry non-commercial by-products, i. Read More

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December 2018

Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies.

J Pharm Biomed Anal 2018 Nov 24;165:119-128. Epub 2018 Nov 24.

Centre of Marine Sciences, University of Algarve, Faculty of Sciences and Technology, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal. Electronic address:

In this study, ethyl acetate, acetone, ethanol and water extracts from flowers, stems and roots of Cistanche phelypaea (L.) Cout were appraised for radical scavenging activity (RSA) towards 1,1-diphenyl-2-picrylhydrazyl,2,2-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) and superoxide free radicals, and for metal chelating activities on iron and copper ions. The water extracts had the highest antioxidant activity, especially those from roots and flowers, and were further appraised for in vitro inhibition of enzymes implicated on the onset of human ailments, namely acetyl- (AChE) and butyrylcholinesterase (BuChE) for Alzheimer's disease, α-glucosidase and α-amylase for diabetes, and tyrosinase for skin hyperpigmentation disorders. Read More

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November 2018

Quantifying proteins at microgram levels integrating gel electrophoresis and smartphone technology.

J Proteomics 2018 Dec 6. Epub 2018 Dec 6.

Spectrometry, Sample Preparation and Mechanization Group - GEPAM, Institute of Chemistry, University of Campinas - UNICAMP, Campinas, Brazil; National Institute of Science and Technology for Bioanalytics, Brazil. Electronic address:

A combination between gel electrophoresis and smartphone technology is applied for quantifying proteins in a serum sample. Electrophoresis not only allows one to separate different proteins but also to build-up a calibration curve for those proteins. To expand its applicability, a smartphone allows one to capture a gel image, through its camera. Read More

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December 2018

Clinical evidence for the immunogenicity and immune persistence of vaccination with yellow fever virus strain 17D in Chinese peacekeepers deployed to Africa.

Antiviral Res 2018 Dec 6. Epub 2018 Dec 6.

Jinan Military Region Center for Disease Control and Prevention, 36 Wenhua Road East, Lixia District, Jinan, Shandong, China.

Yellow fever is a serious disease caused by infection with the yellow fever virus (YFV). A live-attenuated YFV vaccine strain, 17D (YFV-17D) is the only virus strain available for the production of the YFV vaccine. This study evaluated the immunogenicity and immune persistence of vaccination with YFV-17D and identified their influencing factors in Chinese peacekeepers deployed to Africa. Read More

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December 2018

Physicochemical properties of polysaccharides separated from Camellia oleifera Abel seed cake and its hypoglycemic activity on streptozotocin-induced diabetic mice.

Int J Biol Macromol 2018 Dec 5. Epub 2018 Dec 5.

Engineering Research Center of Bio-process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, Anhui, China. Electronic address:

Two homogeneous polysaccharide fractions named SCP-1 (7.16 × 10 Da) and SCP-2 (2.00 × 10 Da) were purified by DEAE-52 cellulose and Sephadex G-200 column chromatography successively from Camellia oleifera Abel seed cake. Read More

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December 2018

Antiadhesion effect of the C17 glycerin ester of isoprenoid-type lipid forming a nonlamellar liquid crystal.

Acta Biomater 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Biomaterials, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan. Electronic address:

Postoperative adhesion is a relevant clinical problem that causes a variety of clinical complications after abdominal surgery. The objective of this study is to develop a liquid-type antiadhesion agent and evaluate its efficacy in preventing tissue adhesion in a rat peritoneal adhesion model. The liquid-type agent was prepared by submicron-sized emulsification of C17 glycerin ester (C17GE), squalene, pluronic F127, ethanol, and water with a high-pressure homogenizer. Read More

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December 2018

Physicochemical and biological properties of longan pulp polysaccharides modified by Lactobacillus fermentum fermentation.

Int J Biol Macromol 2018 Dec 6. Epub 2018 Dec 6.

Sericultural & Agri-food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, PR China. Electronic address:

Longan polysaccharides are valuable compounds with many biological activities. Lactobacillus fermentum was selected to ferment longan pulp and the polysaccharides from unfermented and fermented longan pulp (denoted as LP and LP-F, respectively) were isolated. Their physicochemical, immunomodulatory and prebiotic activities were investigated. Read More

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December 2018

Physical and enzymatic properties of a new manganese peroxidase from the white-rot fungus Trametes pubescens strain i8 for lignin biodegradation and textile-dyes biodecolorization.

Int J Biol Macromol 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Microbial Biotechnology and Engineering Enzymes (LMBEE), Centre of Biotechnology of Sfax (CBS), University of Sfax, Road of Sidi Mansour Km 6, PO Box 1177, Sfax 3018, Tunisia; Biotech ECOZYM Start-up, Business Incubator, Centre of Biotechnology of Sfax (CBS), University of Sfax, Road of Sidi Mansour Km 6, P.O. Box 1177, Sfax 3018, Tunisia. Electronic address:

A new manganese peroxidase-producing white-rot basidiomycete fungus was isolated from symptomatic wood of the camphor trees Cinnamomum camphora (L.) at the Hamma Botanical Garden (Algeria) and identified as Trametes pubescens strain i8. The enzyme was purified (MnP TP55) to apparent electrophoretic homogeneity and biochemically characterized. Read More

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December 2018

Integrated assessment of sediment contaminant levels and biological responses in sentinel fish species Atherinella brasiliensis from a sub-tropical estuary in south Atlantic.

Chemosphere 2018 Dec 1;219:15-27. Epub 2018 Dec 1.

Department of Pharmacology, Federal University of Paraná, P.O. Box 19031, 81530-980, Curitiba, Paraná, Brazil. Electronic address:

This study combined data of the concentrations of metals, polycyclic aromatic hydrocarbons (PAHs) and pharmaceuticals and personal hygiene products (PPCPs) in the sediments and the biological responses of the Atherinella brasiliensis fish in two different sites and climate seasons in the Estuarine-Lagoon Complex of Iguape-Cananéia, Southeast Brazil. The presence of metals, PAHs, and PPCPs were observed in the sediments demonstrating the contamination throughout the system with contributions of sewage and residues disposal, oil and combustion of biomass and fossil fuels. Higher contaminations were identified in the point of greater human presence (C - Cananéia City), especially during the cold-dry season. Read More

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December 2018

Expectations for Phase-Appropriate Drug Substance and Drug Product Specifications for Early-Stage Protein Therapeutics.

J Pharm Sci 2018 Dec 6. Epub 2018 Dec 6.

NBE Development, AbbVie Inc, 1 N Waukegan Road, North Chicago, IL 60064, USA. Electronic address:

Early phase specifications are established to ensure that materials used in clinical studies have appropriate product quality, reducing the risk of harm to patients. Currently, guidance is available for specification setting practices at commercial phase. With very limited data and manufacturing experience available, it is not possible to fully align to these expectations at the start of clinical trials. Read More

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December 2018
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Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology.

J Allergy Clin Immunol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany.

Providers caring for patients with mastocytosis are tasked with the decision to consider therapeutic options. This may come with some trepidation since the information available in the public domain lists numerous mast cell activators based on data that does not discriminate between primates, rodents and mast cell lines, does not consider dosage and does not take into account previous exposure and resultant clinical findings. This being said, there is support in the literature for an enhanced mast cell response in some patients with mastocytosis and where there is higher incidence of adverse reactions associated with certain antigens such as venoms as well as drugs. Read More

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December 2018

Integrated Product Recovery Will Boost Industrial Cyanobacterial Processes.

Trends Biotechnol 2018 Dec 5. Epub 2018 Dec 5.

Bioprocess Engineering, AlgaePARC, Wageningen University, P.O. Box 16, 6700 AA Wageningen, The Netherlands; Nord University, Faculty of Biosciences and Aquaculture, N-8049 Bodø, Norway; https://www.wur.nl/en/Research-Results/Chair-groups/Agrotechnology-and-Food-Sciences/Bioprocess-Engineering.htm. Electronic address:

Cyanobacteria promise to be an important industrial platform for the production of a variety of biobased products such as fuels, plastics, and isoprenoids. Recent advances in synthetic biology have resulted in various cyanobacterial strain improvements. Nevertheless, these new strains are still hampered by product inhibition, resulting in low volumetric productivities, product concentrations, and yields on light. Read More

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December 2018

Modulating the Tumor Microenvironment via Oncolytic Viruses and CSF-1R Inhibition Synergistically Enhances Anti-PD-1 Immunotherapy.

Mol Ther 2018 Nov 17. Epub 2018 Nov 17.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China. Electronic address:

Immunotherapy based on the immune checkpoint blockade has emerged as the most promising approach for cancer therapy. However, the proportion of colorectal cancer patients who benefit from immunotherapy is small due to the immunosuppressive tumor microenvironment. Hence, combination immunotherapy is an ideal strategy to overcome this limitation. Read More

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November 2018

Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus.

Best Pract Res Clin Rheumatol 2018 04 27;32(2):188-205. Epub 2018 Sep 27.

Rheumatology, Clinical Immunology and Allergy, University of Crete, Medical School, Iraklio, Greece. Electronic address:

Obtaining an updated view of the epidemiology, risk factors, and prognosis of systemic lupus erythematosus (SLE) is pivotal to our understanding of the disease burden. Recent community-based studies with comprehensive methodology provided more accurate disease occurrence estimates and suggested that SLE may be more frequent than previously thought. Gender, race, and socioeconomic status are important disease determinants, and there is increasing appreciation of the contribution of family history and environmental exposures in SLE susceptibility. Read More

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April 2018
2.603 Impact Factor

Conventional and biological immunosuppressants in vasculitis.

Best Pract Res Clin Rheumatol 2018 02 22;32(1):94-111. Epub 2018 Aug 22.

Norwich Medical School, University of East Anglia, Norwich Research Park, BCRE Floor 2, NR4 7UQ, UK. Electronic address:

The following chapter outlines the main findings from clinical trials, which provide information on the current best evidence-based management of the myriad of conditions that comprise vasculitis. Glucocorticoids (GCs) have been the mainstay of treatment of large-vessel vasculitis since Birkhead et al. used intramuscular cortisone daily and obtained good results in patients with giant cell arteritis. Read More

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February 2018

The U.N. celebrates a regulatory debacle.

GM Crops Food 2018 Dec 10:1-4. Epub 2018 Dec 10.

b Law & Economics Center, George Mason University , Arlington , USA.

During the early 2000s, delegates to the U.N.-sponsored Convention on Biological Diversity negotiated a "biosafety protocol" to regulate the international movement of organisms genetically modified with the newest, most precise techniques, which they dubbed "living modified organisms," or LMOs. Read More

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December 2018

Ion channels as therapeutic antibody targets.

MAbs 2018 Dec 10:1-32. Epub 2018 Dec 10.

a TetraGenetics Inc , Arlington Massachusetts , USA.

It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may facilitate the discovery of antibody therapeutics to ion channels. Additionally, we discuss the potential targeting opportunities in the anti-ion channel antibody landscape, along with a number of case studies where functional antibodies that target ion channels have been reported. Read More

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December 2018

Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation.

Int J Radiat Biol 2018 Dec 7:1-43. Epub 2018 Dec 7.

a Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy.

Purpose: Radiation-induced gastrointestinal injury or radiation enteropathy is an imminent risk during radiation therapy of abdominal or pelvic tumors. Despite remarkable technological advancements in image-guided radiation delivery techniques, the risk of intestinal injury after radiotherapy for abdominal or pelvic cancers has not been completely eliminated. The irradiated intestine undergoes varying degrees of adverse structural and functional changes, which can result in transient or long-term complications. Read More

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December 2018
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