636,824 results match your criteria Biologics in Therapy [Journal]


Phase I trial of alpelisib in combination with concurrent cisplatin-based chemoradiotherapy in patients with locoregionally advanced squamous cell carcinoma of the head and neck.

Oral Oncol 2020 May 25;108:104753. Epub 2020 May 25.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre/University of Toronto, Toronto, ON, Canada. Electronic address:

Background: Deregulation of the PI3K signalling pathway is frequent in squamous cell carcinoma of the head and neck (SCCHN) and may be implicated in radioresistance. We report on the results from a phase I 3 + 3 dose escalation study of alpelisib, a class I α-specific PI3K inhibitor in combination with concurrent cisplatin-based chemoradiation (CRT) in patients with locoregionally advanced SCCHN (LA-SCCHN).

Methods: Eligible patients had previously untreated LA-SCCHN and were candidates for CRT. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104753DOI Listing

Does salinity variation increase synergistic effects of triclosan and carbon nanotubes on Mytilus galloprovincialis? Responses on adult tissues and sperms.

Sci Total Environ 2020 May 5;734:138837. Epub 2020 May 5.

Interuniversity Consortium of Marine Biology of Leghorn "G. Bacci", 57128 Livorno, Italy; Department of Veterinary Sciences, University of Pisa, San Piero a Grado, 56122 Pisa, Italy.

The use of carbon nanotubes (CNTs) is rapidly increasing and several scientific studies have addressed their toxicological properties. However, only a very small number of publications have deal with the interaction between CNTs and other molecules. Triclosan (TCS) is an antibacterial agent used in personal care and household products. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138837DOI Listing

Maternal treatment with oral intestinal alkaline phosphatase mitigates high fat diet-induced cognitive disorders in offspring mice.

Behav Brain Res 2020 May 25:112701. Epub 2020 May 25.

Synthetic Biologics, Inc. Maryland, USA.

Intestinal alkaline phosphatase (IAP) is an endogenous enzyme that promotes gastrointestinal homeostasis by detoxifying inflammatory mediators, tightening the gut barrier and promoting a healthy microbiome. Oral IAP administration was efficacious in ameliorating diabetes in a high fat diet (HFD) induced murine model. In humans, maternal obesity and diabetes during pregnancy has been associated with an increased risk of autism spectrum disorders (ASD). Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112701DOI Listing

Comparison of two acid hydrotropes for sustainable fractionation of birch wood.

ChemSusChem 2020 May 28. Epub 2020 May 28.

USDA Forest Service, Forest Products Lab, 1 Gifford Pinchot Dr, 53726, Madison, UNITED STATES.

This study reports on a comparative study of acid hydrotropic fractionation (AHF) of birch wood using maleic acid (MA) and p-toluenesulfonic acid (p-TsOH). Under the same level of delignification, lignin dissolved by MA is much less condensed with a higher content of ether aryl β-O-4 linkages. Lignin depolymerization dominated in MA hydrotropic fractionation (MAHF) and resulted in a single lower Mw peak, in contrast to the competitive depolymerization and repolymerization in p-TsOH HF with a bimodal distribution. Read More

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http://dx.doi.org/10.1002/cssc.202001120DOI Listing

Treatment Pathways Leading to Biologic Therapies for Ulcerative Colitis and Crohn's Disease in the United States.

Clin Transl Gastroenterol 2020 Feb;11(2):e00128

Celgene Corporation, Summit, New Jersey, USA.

Objectives: Biologic therapies have been available for inflammatory bowel disease for >20 years, but patient outcomes have not changed appreciably over this time period. To better understand medication utilization for this disease, we evaluated a novel technique for visualizing treatment pathways, including initial treatment, switching, and combination therapies.

Methods: This retrospective, observational study used administrative claims data from the Truven Health MarketScan Commercial and Medicare Database. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000128DOI Listing
February 2020

Effects of the apple matrix on the postprandial bioavailability of flavan-3-ols and nutrigenomic response of apple polyphenols in minipigs challenged with a high fat meal.

Food Funct 2020 May 28. Epub 2020 May 28.

Université Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, France.

Food matrix interactions with polyphenols can affect their bioavailability and as a consequence may modulate their biological effects. The aim of this study was to determine if the matrix and its processing would modulate the bioavailability and the postprandial nutrigenomic response to a dietary inflammatory stress of apple flavan-3-ol monomers. We carried out an acute randomized controlled study in minipigs challenged with a high fat meal (HFM) supplemented with raw fruit, puree, or apple phenolic extract with matched content of flavan-3-ol monomers. Read More

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http://dx.doi.org/10.1039/d0fo00346hDOI Listing

The immune-enhancing potential of peptide fractions from fermented Spirulina platensis by mixed probiotics.

J Food Biochem 2020 May 27:e13245. Epub 2020 May 27.

Beijing Key Laboratory of Forest Food Processing and Safety, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing, China.

Mixed fermentation with different microorganisms can facilitate fermentation metabolism and increase the low molecular metabolites accumulation, thereby enhancing the bioactive activity. In this study, we evaluated the immune-stimulating activities of Spirulina platensis and different extracts from fermented S. platensis (FS) by mixed probiotics in vitro, by measuring the proliferation and Th1/Th2 immunomodulatory potential on murine primary splenic lymphocytes. Read More

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http://dx.doi.org/10.1111/jfbc.13245DOI Listing

Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis.

Biomed Res Int 2020 3;2020:8797284. Epub 2020 May 3.

Department of Biological Sciences, Faculty of Science, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.

Inflammatory diseases are a real public health problem worldwide. Many synthetic drugs used in the treatment of inflammatory diseases such as steroidal anti-inflammatory drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressive drugs have harmful side effects. However, there are natural products like propolis, which is traditionally used in the treatment of pain. Read More

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http://dx.doi.org/10.1155/2020/8797284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222486PMC

Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis.

Exp Mol Med 2020 May 27. Epub 2020 May 27.

Department of Biomedicine and Health Sciences, The Catholic University of Korea, Seoul, Korea.

Angiogenesis and synoviocyte hyperplasia, called 'pannus,' are pathologic hallmarks of rheumatoid arthritis (RA). To determine the clinical significance of angiogenic cytokines in RA, the levels of pro-angiogenic cytokines, including VEGF, placenta growth factor (PlGF), and IL-6, were measured in the synovial fluid (SF, n = 54) and sera of RA patients (n = 157) using ELISA. Patients (n = 103) with disease activity score 28 (DAS28) > 3. Read More

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http://dx.doi.org/10.1038/s12276-020-0443-8DOI Listing

Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications.

Korean J Intern Med 2020 May 29. Epub 2020 May 29.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncontrolled or partially controlled status despite intensive treatment. Read More

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http://dx.doi.org/10.3904/kjim.2020.022DOI Listing

Recent advances in dissecting the demethylation reactions in natural product biosynthesis.

Curr Opin Chem Biol 2020 May 24;59:47-53. Epub 2020 May 24.

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address:

Demethylation is a chemical process widely distributed in nature to remove a methyl group from an organic molecule, which is a key aspect of diverse biological processes including biosynthesis of natural products, degradation of plant biomass and epigenetic regulation. This process is facilitated by diverse demethylases via distinct mechanisms. Recent studies have disclosed some novel demethylation reactions as well as their underlying demethylases in the biosynthesis of bacterial sterols, fungal terpenoids, and plant alkaloids. Read More

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http://dx.doi.org/10.1016/j.cbpa.2020.04.014DOI Listing

Genetically modified entomopathogenic bacteria, recent developments, benefits and impacts: A review.

Sci Total Environ 2020 May 11;734:139169. Epub 2020 May 11.

Department of Crop and Animal Production, Safiye Cikrikcioglu Vocational College, Kayseri University, Kayseri, Turkey.

Entomopathogenic bacteria (EPBs), insect pathogens that produce pest-specific toxins, are environmentally-friendly alternatives to chemical insecticides. However, the most important problem with EPBs application is their limited field stability. Moreover, environmental factors such as solar radiation, leaf temperature, and vapor pressure can affect the pathogenicity of these pathogens and their toxins. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139169DOI Listing

Process type is the key driver of the fate of organic micropollutants during industrial scale treatment of organic wastes.

Sci Total Environ 2020 May 11;734:139108. Epub 2020 May 11.

INRAE, Univ Montpellier, LBE, 102 Avenue des étangs, 11100 Narbonne, France. Electronic address:

Organic micropollutants (OMPs) such as polycyclic aromatic hydrocarbons, nonylphenols and pharmaceutical products are ubiquitous in organic wastes generated by most human activities. Those wastes are mainly recycled by land spreading, most often after treatments, such as liming, dewatering, composting or anaerobic digestion. It has been shown essentially at lab scales that biological treatments have an effect on the removal of some OMPs. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139108DOI Listing

A Neurotrophic Mechanism Directs Sensory Nerve Transit in Cranial Bone.

Cell Rep 2020 May;31(8):107696

Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:

The flat bones of the skull are densely innervated during development, but little is known regarding their role during repair. We describe a neurotrophic mechanism that directs sensory nerve transit in the mouse calvaria. Patent cranial suture mesenchyme represents an NGF (nerve growth factor)-rich domain, in which sensory nerves transit. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107696DOI Listing

Matrix Metalloproteinases as New Targets in Alzheimer's Disease: Opportunities and Challenges.

J Med Chem 2020 May 27. Epub 2020 May 27.

Although matrix metalloproteinases (MMPs) are implicated in the regulation of numerous physiological processes, evidence of their pathological roles have also been obtained in the last decades, making MMPs attractive therapeutic targets for several diseases. Recent discoveries of their involvement in central nervous system (CNS) disorders, and in particular in Alzheimer's disease (AD), have paved the way to consider MMP modulators as promising therapeutic strategies. Over the past few decades, diverse approaches have been undertaken in the design of therapeutic agents targeting MMPs for various purposes, leading, more recently, to encouraging developments. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.0c00352DOI Listing

[Physiological effects, mechanisms of action and application of lactulose].

Vopr Pitan 2020 16;89(2):5-20. Epub 2020 Mar 16.

North-Caucasus Federal University, 355009, Stavropol, Russian Federation.

The discovery of lactulose as a bifidogenic factor became the background for the appearance of the prebiotics concept. Currently, lactulose is the most studied in terms of medical use oligosaccharide with a high prebiotic index. The exact mechanisms of action of lactulose remain largely unknown despite a number of new researches based on modern methods of molecular biology, genetics, and bioinformatics. Read More

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http://dx.doi.org/10.24411/0042-8833-2020-10012DOI Listing

NASPGHAN Position Paper: Plant-Based Milks.

J Pediatr Gastroenterol Nutr 2020 May 26. Epub 2020 May 26.

Associate Professor, Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Alberta, Alberta, Edmonton, Canada, Potential Conflict of Interest, Research funding from VectiveBio AG, for the NASPGHAN Committee on Nutrition.

Parents and caretakers are increasingly feeding infants and young children plant-based "milk" alternatives to cow milk. The US Food and Drug Administration currently defines "milk" and related milk products by the product source and the inherent nutrients provided by bovine milk. Substitution of a milk that does not provide a similar nutritional profile to cow milk can be deleterious to a child's nutritional status, growth and development. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002799DOI Listing

Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility.

Org Lett 2020 May 27. Epub 2020 May 27.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.

A synthesis program for structurally complex macrocycles is very challenging. Herein, we propose a biosynthesis pathway of the pyranylated cyclodepsipeptide verucopeptin to make enough supply and to diversify verucopeptin by genetic manipulation and one-step semisynthesis. The synthesis relies on the intrinsic reactivity of the interchangeable hemiketal pyrane and opened keto along with adjacent alkene. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01387DOI Listing

Pathogenesis-Based Therapy With Repurposed Biologics for Monogenic Inflammatory Skin Disorders.

Authors:
Amy S Paller

JAMA Dermatol 2020 May 27. Epub 2020 May 27.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamadermatol.2020.1018DOI Listing

Anti-inflammatory effect of omega unsaturated fatty acids and dialysable leucocyte extracts on collagen-induced arthritis in DBA/1 mice.

Int J Exp Pathol 2020 May 27. Epub 2020 May 27.

Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.

Rheumatoid arthritis is a disabling autoimmune disease with a high global prevalence. Treatment with disease-modifying anti-arthritic drugs (DIMARDs) has been routinely used with beneficial effects but with adverse long-term consequences; novel targeted biologics and small-molecule inhibitors are promising options. In this study, we investigated whether purified omega unsaturated fatty acids (ω-UFAs) and dialysable leukocyte extracts (DLEs) prevented the development of arthritis in a model of collagen-induced arthritis (CIA) in mice. Read More

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http://dx.doi.org/10.1111/iep.12348DOI Listing

Diving into the world of marine 2,11-cyclized cembranoids: a summary of new compounds and their biological activities.

Nat Prod Rep 2020 May 27. Epub 2020 May 27.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China. and University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.

Covering: 2010 to 2020The class of 2,11-cyclized cembranoids is particularly widespread in marine Octocorallia, especially Alcyonacea and Gorgonacea, and has been extensively studied. Following a previous review published in 2010, the accumulated knowledge from the past decade will be presented here. All 2,11-cyclized cembranoids share a bicyclo[8. Read More

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http://dx.doi.org/10.1039/d0np00016gDOI Listing

Surfactant and oil formulations for monodisperse droplet emulsion PCR.

Lab Chip 2020 May 27. Epub 2020 May 27.

Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China. and Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing 100871, China and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China and College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China and Institute for Cell Analysis, Shenzhen Bay Laboratory, Guangdong 518132, China and Chinese Institute for Brain Research, Beijing 102206, China.

Emulsion PCR has become a popular and widely applied method in biological research and clinical diagnostics to provide evenly amplified products and perform highly quantitative counting of target sequences. However, there is still a lack of information to support further development of appropriate water-in-oil emulsion formulations, which need to be both thermally and mechanically stable for digital amplification reactions. Here, we present a systematic survey of the oil and surfactant components of stable monodisperse w/o emulsions suitable for use with our previously developed micro-capillary array (MiCA)-based centrifugal emulsion generation method. Read More

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http://dx.doi.org/10.1039/d0lc00052cDOI Listing

Is insulin intoxication still the perfect crime? Analysis and interpretation of postmortem insulin: review and perspectives in forensic toxicology.

Crit Rev Toxicol 2020 May 27:1-24. Epub 2020 May 27.

Laboratoire de Toxicologie, ISPB-Faculté de Pharmacie, Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France.

Insulin is an anabolic hormone essential to glucose homeostasis. Insulin therapy, comprising human insulin (HI) or biosynthetic analogs, is critical for the management of type-1 diabetes and many of type-2 diabetes. However, medication error including non-adapted dose and confusion of insulin type, and misuse, such as massive self-administration or with criminal intent, can have lethal consequences. Read More

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http://dx.doi.org/10.1080/10408444.2020.1762540DOI Listing

Evaluation of the Biological Efficiency of Silver Nanoparticles Biosynthesized Using Croton tiglium L. Seeds Extract against Azoxymethane Induced Colon Cancer in Rats.

Asian Pac J Cancer Prev 2020 May 1;21(5):1369-1389. Epub 2020 May 1.

Animal Reproduction and Artificial Insemination Department, Veterinary Division, National Research Centre, Dokki, Giza, Egypt .

Background: Colorectal cancer (CRC) is considered as the most common type of gastrointestinal cancers. Chemotherapy became limited due to the adverse side effects. Therefore, the most effective Croton tiglium extract was selected to be incorporated by silver nanoparticles (Ag-NPs) then evaluated against colon cancer induced by azoxymethane (AOM) in rats. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1369DOI Listing

Evolutionary links between intra- and extracellular acid-base regulation in fish and other aquatic animals.

J Exp Zool A Ecol Integr Physiol 2020 May 26. Epub 2020 May 26.

Department of Zoology, University of British Columbia, Vancouver, Canada.

The acid-base relevant molecules carbon dioxide (CO ), protons (H ), and bicarbonate (HCO ) are substrates and end products of some of the most essential physiological functions including aerobic and anaerobic respiration, ATP hydrolysis, photosynthesis, and calcification. The structure and function of many enzymes and other macromolecules are highly sensitive to changes in pH, and thus maintaining acid-base homeostasis in the face of metabolic and environmental disturbances is essential for proper cellular function. On the other hand, CO , H , and HCO have regulatory effects on various proteins and processes, both directly through allosteric modulation and indirectly through signal transduction pathways. Read More

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http://dx.doi.org/10.1002/jez.2367DOI Listing

Biological characterization of dehydrated amniotic membrane allograft: Mechanisms of action and implications for wound care.

J Biomed Mater Res B Appl Biomater 2020 May 26. Epub 2020 May 26.

J. Crayton Pruitt Family Department of Biomedical Engineering , University of Florida, Gainesville, Florida, USA.

There is a growing clinical demand in the wound care market to treat chronic wounds such as diabetic foot ulcers. Advanced cell and tissue-based products (CTPs) are often used to address challenging chronic wounds where healing has stalled. These products contain active biologics such as growth factors and cytokines as well as structural components that support and stimulate cell growth and assist in tissue regeneration. Read More

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http://dx.doi.org/10.1002/jbm.b.34635DOI Listing

Considerations for Safety in the Use of Systemic Medications for Psoriasis and Atopic Dermatitis during the COVID-19 pandemic.

Dermatol Ther 2020 May 27. Epub 2020 May 27.

Department of Dermatology, Weill Cornell Medicine, NY, NY.

Coronavirus disease 2019 (COVID-19), is responsible for at least 2,546,527 cases and 175,812 deaths as of April 21, 2020. Psoriasis and atopic dermatitis are common, chronic, inflammatory skin conditions, with immune dysregulation as a shared mechanism; therefore, mainstays of treatment include systemic immunomodulating therapies. It is unknown whether these therapies are associated with increased to COVID-19 susceptibility or worse outcomes in infected patients. Read More

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http://dx.doi.org/10.1111/dth.13687DOI Listing

The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion.

Mol Neurobiol 2020 May 26. Epub 2020 May 26.

I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Str., Moscow, Russia, 119991.

Oxidative stress associated with chronic cerebral hypoperfusion is one of the fundamental factors leading to neurodegenerative diseases. To prevent oxidative stress, physical activity is effective. Physical exercise enables development of rehabilitation techniques that can progressively increase patients' stress resistance. Read More

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http://dx.doi.org/10.1007/s12035-020-01930-5DOI Listing

Botanical insecticide-based nanosystems for the control of Aedes (Stegomyia) aegypti larvae.

Environ Sci Pollut Res Int 2020 May 27. Epub 2020 May 27.

School of Pharmaceutical Sciences, São Paulo State University-UNESP, Rodovia Araraquara Jaú, Km 01, s/n, Campos Ville, Araraquara, SP, 14800-903, Brazil.

Aedes (Stegomyia) aegypti is a cosmopolitan species that transmits arbovirus of medical importance as dengue, Zika, and chikungunya. The main strategy employed for the control of this mosquito is the use of larvicidal agents. However, the overuse of synthetic chemical larvicides has led to an increase in resistant insects, making management difficult. Read More

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http://dx.doi.org/10.1007/s11356-020-09278-yDOI Listing

Nano-bio interactions: the implication of size-dependent biological effects of nanomaterials.

Sci China Life Sci 2020 May 25. Epub 2020 May 25.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.

Due to their many advantageous properties, nanomaterials (NMs) have been utilized in diverse consumer goods, industrial products, and for therapeutic purposes. This situation leads to a constant risk of exposure and uptake by the human body, which are highly dependent on nanomaterial size. Consequently, an improved understanding of the interactions between different sizes of nanomaterials and biological systems is needed to design safer and more clinically relevant nano systems. Read More

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http://dx.doi.org/10.1007/s11427-020-1725-0DOI Listing

Microbiome characterization and re-design by biologic agents for inflammatory bowel disease insights.

Bioprocess Biosyst Eng 2020 May 26. Epub 2020 May 26.

Department of Gastrointestinal Surgery, Zhujiang Hospital, Southern Medical University, GuangZhou, 510280, China.

The therapeutic effect of inflammatory bowel disease has improved in the past decades, but most of patients cannot tolerate, do not respond to drugs, or relapse after treating with conventional therapy. Therefore, new and more effective treatment methods are still needed in treatment of IBD. In this review, we will discuss the relevant mechanisms and the latest research progress of biologics (anti-TNF treatments, interleukin inhibitors, integrin inhibitors, antisense oligonucleotide, and JAK inhibitors) for IBD, focus on the efficacy and safety of drugs for moderate-to-severe IBD, and summarize the clinical status and future development direction of biologics in IBD. Read More

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http://dx.doi.org/10.1007/s00449-020-02380-yDOI Listing

Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity.

Front Immunol 2020 8;11:832. Epub 2020 May 8.

Departments of Oncology Research, Amgen Research, South San Francisco, CA, United States.

Inhibitors that block the programmed cell death-1 (PD-1) pathway can potentiate endogenous antitumor immunity and have markedly improved cancer survival rates across a broad range of indications. However, these treatments work for only a minority of patients. The efficacy of anti-PD-1 inhibitors may be extended by cytokines, however, the incorporation of cytokines into therapeutic regimens has significant challenges. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225340PMC

Complete Mitochondrial Genome of the Fungal Biocontrol Agent : Genomic Features, Comparative Analysis and Insight Into the Mitochondrial Evolution in .

Authors:
Yunyoung Kwak

Front Microbiol 2020 28;11:785. Epub 2020 Apr 28.

Écologie, Systématique et Évolution, CNRS, Université Paris Sud (Paris XI), Université Paris Saclay, AgroParisTech, Orsay, France.

The improvement of biopesticides for use in the agriculture industry requires an understanding of the biological- and ecological principles underlying their behavior in natural environments. The nuclear genomes of members of the genus , which are representative fungal biocontrol agents, have been actively studied in relation to the unique characteristics of these species as effective producers of CAZymes/secondary metabolites and biopesticides, but their mitochondrial genomes have received much less attention. In this study, the mitochondrial genome of (Hypocreales, Sordariomycetes), which targets wood-decaying fungal pathogens and has the ability to degrade chemical fungicides, was assembled . Read More

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http://dx.doi.org/10.3389/fmicb.2020.00785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228111PMC

Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.

Sci Rep 2020 May 26;10(1):8691. Epub 2020 May 26.

Plant Genomic Network Research Team, RIKEN Center for Sustainable Resource Science (CSRS), Yokohama, 230-0045, Japan.

Chemical priming is an attractive and promising approach to improve abiotic stress tolerance in a broad variety of plant species. We screened the RIKEN Natural Products Depository (NPDepo) chemical library and identified a novel compound, FSL0260, enhancing salinity-stress tolerance in Arabidopsis thaliana and rice. Through transcriptome analysis using A. Read More

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http://dx.doi.org/10.1038/s41598-020-65614-9DOI Listing

Assessment of computed tomography perfusion software in predicting spatial location and volume of infarct in acute ischemic stroke patients: a comparison of Sphere, Vitrea, and RAPID.

J Neurointerv Surg 2020 May 26. Epub 2020 May 26.

Biomedical Engineering, University at Buffalo-The State University of New York, Buffalo, New York, USA

Background: CT perfusion (CTP) infarct and penumbra estimations determine the eligibility of patients with acute ischemic stroke (AIS) for endovascular intervention. This study aimed to determine volumetric and spatial agreement of predicted RAPID, Vitrea, and Sphere CTP infarct with follow-up fluid attenuation inversion recovery (FLAIR) MRI infarct.

Methods: 108 consecutive patients with AIS and large vessel occlusion were included in the study between April 2019 and January 2020 . Read More

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http://dx.doi.org/10.1136/neurintsurg-2020-015966DOI Listing

Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an -prenyltransferase.

Proc Natl Acad Sci U S A 2020 May 26. Epub 2020 May 26.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093;

Prenylation is a common biological reaction in all domains of life wherein prenyl diphosphate donors transfer prenyl groups onto small molecules as well as large proteins. The enzymes that catalyze these reactions are structurally distinct from ubiquitous terpene cyclases that, instead, assemble terpenes via intramolecular rearrangements of a single substrate. Herein, we report the structure and molecular details of a new family of prenyltransferases from marine algae that repurposes the terpene cyclase structural fold for the -prenylation of glutamic acid during the biosynthesis of the potent neurochemicals domoic acid and kainic acid. Read More

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http://dx.doi.org/10.1073/pnas.2001325117DOI Listing

Development and Evaluation of an Inactivated Lumpy Skin Disease Vaccine for Cattle.

Vet Microbiol 2020 Jun 18;245:108689. Epub 2020 Apr 18.

Research and development Virology, Multi-Chemical Industry, Lot. 157, ZI Sud-Ouest (ERAC) B.P: 278, Mohammedia 28810, Morocco.

Lumpy skin disease (LSD) of cattle is caused by a virus within Capripoxvirus genus. It leads to huge economic losses in addition to trade and animal movement limitation. Vaccination is the only economically feasible way to control this vector-borne disease. Read More

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http://dx.doi.org/10.1016/j.vetmic.2020.108689DOI Listing

Hemp ( L.) Protein Hydrolysates Promote Anti-Inflammatory Response in Primary Human Monocytes.

Biomolecules 2020 May 22;10(5). Epub 2020 May 22.

Department of Food & Health, Instituto de la Grasa, CSIC, 41013 Seville, Spain.

Hemp seeds have a wide variety of chemical compounds which present biological activity. Specifically, the focus on proteins and bioactive peptides are increasing as alternative sources of nutraceutical uses. In the literature, hemp protein products (HPPs) have reported antioxidant and anti-inflammatory properties. Read More

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http://dx.doi.org/10.3390/biom10050803DOI Listing

Characterization of Enriched Meat-Based Pâté Manufactured with Oleogels as Fat Substitutes.

Gels 2020 May 22;6(2). Epub 2020 May 22.

International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal.

Nowadays, one of the strongest factors affecting consumers' choice at the moment of purchasing food products is their nutritional features. The population is increasingly aware of the diet-health relationship and they are opting for a healthy lifestyle. Concerns with the increasing number of heart-related diseases, which are associated to the consumption of fats, are placing the functional food market in a relevant growth position. Read More

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http://dx.doi.org/10.3390/gels6020017DOI Listing

Light Microscopy as a Tool to Evaluate the Functionality of Starch in Food.

Foods 2020 May 22;9(5). Epub 2020 May 22.

Department of Biotechnology and Food Microbiology, Poznań University of Life Sciences, 48 Wojska Polskiego St., 60-627 Poznań, Poland.

Light microscopy (LM) is commonly used in the study of biological materials to determine the morphology of cells and tissues. The potential of this technique for studying the structure of food products is also recognized but less known. Especially rare are information regarding LM studies of the supramolecular structure of starch. Read More

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http://dx.doi.org/10.3390/foods9050670DOI Listing

Northern Sea Cucumber (): A Potential Candidate for Functional Food, Nutraceutical, and Pharmaceutical Sector.

Mar Drugs 2020 May 22;18(5). Epub 2020 May 22.

Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1B 3X9, Canada.

Sea cucumber () is the most abundant and widely distributed species in the cold waters of North Atlantic Ocean. contains a wide range of bioactive compounds, mainly collagen, cerebrosides, glycosaminoglycan, chondroitin sulfate, saponins, phenols, and mucopolysaccharides, which demonstrate unique biological and pharmacological properties. In particular, the body wall of this marine invertebrate is the major edible part and contains most of the active constituents, mainly polysaccharides and collagen, which exhibit numerous biological activities, including anticancer, anti-hypertensive, anti-angiogenic, anti-inflammatory, antidiabetic, anti-coagulation, antimicrobial, antioxidation, and anti- osteoclastogenic properties. Read More

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http://dx.doi.org/10.3390/md18050274DOI Listing

Polish Propolis-Chemical Composition and Biological Effects in Tongue Cancer Cells and Macrophages.

Molecules 2020 May 22;25(10). Epub 2020 May 22.

Department of Engineering and Technology of Chemical Processes, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.

The purpose of this study was to compare the chemical composition and biological properties of Polish propolis. Ethanol, ethanol-hexane, hexane and hexane-ethanol extracts of propolis from three different regions of Poland were prepared. On the basis of the evaluation of their chemical composition as well as the extraction yield and free radical scavenging activity, the ethanol and hexane-ethanol extractions were proposed as the most effective methods. Read More

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http://dx.doi.org/10.3390/molecules25102426DOI Listing

Microbial Transglutaminase as a Tool to Improve the Features of Hydrocolloid-Based Bioplastics.

Int J Mol Sci 2020 May 22;21(10). Epub 2020 May 22.

Department of Chemical Sciences, University of Naples "Federico II", 80126 Naples, Italy.

Several proteins from animal and plant origin act as microbial transglutaminase substrate, a crosslinking enzyme capable of introducing isopeptide bonds into proteins between the aminoacids glutamines and lysines. This feature has been widely exploited to modify the biological properties of many proteins, such as emulsifying, gelling, viscosity, and foaming. Besides, microbial transglutaminase has been used to prepare bioplastics that, because made of renewable molecules, are able to replace the high polluting plastics of petrochemical origin. Read More

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http://dx.doi.org/10.3390/ijms21103656DOI Listing

A Review on: Phase '0' Clinical Trials or Exploratory Investigational New Drug.

Turk J Pharm Sci 2017 Apr 15;14(1):84-89. Epub 2017 Apr 15.

Anuradha College Of Pharmacy, Department Of Pharmaceutical Chemistry, Maharashtra, India.

In a move to speed up the development of new medicines, the Food and Drug Administration announced in January 2006 the creation of the exploratory Investigational New Drug (IND), the so-called phase '0' clinical trials. This guidance is intended to clarify what preclinical and clinical approaches, as well as chemistry, manufacturing, and controls information, should be considered when planning exploratory studies in humans, including studies of closely related drugs or therapeutic biological products, under an IND application (21 CFR 312). Existing regulations allow a great deal of flexibility in the amount of data that needs to be submitted with an IND application, depending on the goals of the proposed investigation, the specific human testing proposed, and the expected risks. Read More

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http://dx.doi.org/10.4274/tjps.63935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227998PMC

Anti-inflammatory, Antiplatelet Aggregation, and Antiangiogenesis Polyketides from : Toward an Understating of Its Biological Activities and Potential Applications.

ACS Omega 2020 May 6;5(19):11092-11099. Epub 2020 May 6.

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

The ethyl acetate extract of an endophyte exhibited anti-inflammatory activity at a concentration of <10 μg/mL. By bioassay-guided fractionation, one new compound, named epicorepoxydon A (), and one unusual bioactive compound, 6-(hydroxymethyl)benzene-1,2,4-triol (), together with six known compounds, were isolated from . The structures of all isolates were established by spectroscopic analyses. Read More

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http://dx.doi.org/10.1021/acsomega.0c01000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241018PMC

Total Synthesis of Naturally Occurring 5,7,8-Trioxygenated Homoisoflavonoids.

ACS Omega 2020 May 6;5(19):11043-11057. Epub 2020 May 6.

College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.

Homoisoflavonoids are in the subclass of the larger family of flavonoids but have one more alkyl carbon than flavonoids. Among them, 5,7,8-trioxygenated homoisoflavonoids have not been extensively studied for synthesis and biological evaluation. Our current objective is to synthesize 2 5,7,8-trioxygenated chroman-4-ones and 12 5,7,8-trioxygenated homoisoflavonoids that have been isolated from the plants , , , , , , , , and . Read More

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http://dx.doi.org/10.1021/acsomega.0c00932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241036PMC

Comparison of Transcriptomics Changes Induced by TCS and MTCS Exposure in Human Hepatoma HepG2 Cells.

ACS Omega 2020 May 6;5(19):10715-10724. Epub 2020 May 6.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

Triclosan (TCS) has been a widely used antibacterial agent in medical and personal care products in the last few decades. Methyl TCS (MTCS) is the major biotransformation product of TCS through replacement of the hydroxyl group with methoxy. Previous studies revealed that MTCS showed reduced toxicity but enhanced environmental persistence, when compared with TCS. Read More

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http://dx.doi.org/10.1021/acsomega.0c00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240827PMC

The Anticancer and Anti-inflammatory Effects of Extract on Human Cancer Cell Lines.

Turk J Pharm Sci 2019 Sep 10;16(3):273-281. Epub 2019 Jul 10.

Muğla Sıtkı Koçman University, Department of Biology, Division of Molecular Biology and Biotechnology, Muğla, Turkey.

Objectives: Natural products originating from plants have been used for many years in the treatment of various diseases, including cancer. subsp. is used in Turkish folk medicine. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.27146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227956PMC
September 2019

3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.

Environ Pollut 2020 May 7;265(Pt B):114697. Epub 2020 May 7.

State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China. Electronic address:

3-Acetyldeoxynivalenol (3-Ac-DON), the acetylated derivative of deoxynivalenol (DON), has been reported to be coexisted with DON in various cereal grains. Ingestion of grain-based food products contaminated by 3-Ac-DON might exert deleterious effects on the health of both humans and animals. However, the biological toxicity of 3-Ac-DON on macrophages and the underlying mechanisms remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114697DOI Listing
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