3,949,579 results match your criteria Biologicals : journal of the International Association of Biological Standardization[Journal]


Lifetime Psychosocial Stress Exposure Associated with Hypertensive Disorders of Pregnancy.

Am J Perinatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Obstetrics and Gynecology, NorthShore University Health System, Center for Healthcare Studies, Institute for Public Health and Medicine, University of Chicago Pritzker School of Medicine, Northwestern University, Evanston, Illinois.

Objective:  Hypertensive disorders of pregnancy (HDP) complicate 5 to 10% of all pregnancies and are a major cause of pregnancy-related morbidity. Exposure to psychosocial stress has been associated with systemic inflammation and adverse birth outcomes in pregnant women. Thus, it is probable that psychosocial stress and inflammation play a role in the development of HDP. Read More

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http://dx.doi.org/10.1055/s-0040-1713368DOI Listing

[Non-inflammatory muscle pain].

Dtsch Med Wochenschr 2020 Jul 2;145(13):887-894. Epub 2020 Jul 2.

Muscle pain as a common symptom in daily practice frequently occurs as a non-specific accompanying symptom in multiple internal and neurological diseases. Primarily inflammatory or autoimmune muscular diseases are causing muscle pain. However, a number of non-inflammatory causes of pain can also be considered for differential diagnosis. Read More

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http://dx.doi.org/10.1055/a-1068-5210DOI Listing

Simultaneous quantification of endocannabinoids, oleoylethanolamide and steroid hormones in human plasma and saliva.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 20;1152:122252. Epub 2020 Jun 20.

Central Science Laboratory, University of Tasmania, Australia.

Endogenous cannabinoids are an increasingly intriguing target for biological research, given the changing legal status of medicinal cannabinoid-based products throughout the world. However, studying the endogenous cannabinoid system is a relatively new field, with few research teams attempting to develop quantitative methods for these important modulatory analytes in human matrices, other than blood. Here we develop and validate simultaneous methods for quantifying arachidonoyl-ethanolamide, 2-arachidonoyl glycerol, oleoylethanolamide, cortisol and progesterone in human plasma and saliva using liquid-liquid extraction combined with ultra-high performance liquid chromatography coupled to tandem mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122252DOI Listing

Maternal cigarette use during pregnancy and school readiness: An analysis of preschool age children in São Paulo, Brazil.

Early Hum Dev 2020 Jun 5;148:105103. Epub 2020 Jun 5.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, United States of America.

Background: Barriers to early childhood development (ECD) are a global concern. Limited research exists on prenatal smoking and ECD in vulnerable populations, especially as it relates to school readiness (SR).

Aims: To examine how maternal cigarette use during pregnancy is associated with SR in a sample of Brazilian preschool-age children. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2020.105103DOI Listing

Bioconversion of swine manure into high-value products of medium chain fatty acids.

Waste Manag 2020 Jun 29;113:478-487. Epub 2020 Jun 29.

Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China; Key Laboratory of Energy Conservation and Waste Treatment of Agricultural Structures, Ministry of Agriculture, Beijing 100081, China.

This research proposes and demonstrates, for the first time, the utilization of swine manure as a complex feedstock to produce high-value medium chain fatty acids (MCFA). The two-stage anaerobic digestion (AD) carboxylates platform was adopted for the conversion of swine manure to short chain fatty acids (SCFAs) and then SCFAs to MCFA (n-caproate, n-heptanoate, and n-caprylate) with ethanol supplementation. We defined the appropriate initial pH of 10. Read More

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http://dx.doi.org/10.1016/j.wasman.2020.06.021DOI Listing

Rapid diagnostic tests to address challenges for global measles surveillance.

Curr Opin Virol 2020 Jun 29;41:77-84. Epub 2020 Jun 29.

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Recently, a lateral flow rapid diagnostic test (RDT) with good accuracy has been described. This test enables measles specific IgM antibody detection in serum, capillary blood and oral fluid. RDTs have the potential to transform measles surveillance by allowing real-time case confirmation outside of central/regional laboratories and by facilitating a timely public health response. Read More

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http://dx.doi.org/10.1016/j.coviro.2020.05.007DOI Listing

Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice.

Int Immunopharmacol 2020 Jun 29;86:106723. Epub 2020 Jun 29.

School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China. Electronic address:

Diclofenac (DCF) is a widely used nonsteroidal anti-inflammatory drug, but it comes with a high risk of drug-induced liver injury (DILI). Despite the quinone-imine adduct pathways, the immunotoxicity is recently considered as another factor for DILI. However, such immune responses are still elusive. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106723DOI Listing

A novel cold biorefinery approach for isolation of high quality fish oil in parallel with gel-forming proteins.

Food Chem 2020 Jun 11;332:127294. Epub 2020 Jun 11.

Department of Biology and Biological Engineering-Food and Nutrition Science, Chalmers University of Technology, SE 412 96 Gothenburg, Sweden.

The pH-shift process for isolation of gel-forming proteins from fish processing by-products was extended to allow parallel isolation of fish oil. Subjecting the floating emulsion layer formed during pH-shift processing of salmon by-products to pH-adjustment or freeze/thawing efficiently released the emulsified oil at 4 °C. However, for herring by-products higher temperature (10 °C) and a combination of the emulsion-breaking techniques was required for efficient oil release. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127294DOI Listing

Development and validation of immunoassays for monitoring of guselkumab and anti-guselkumab antibodies in patients with moderate-to-severe psoriasis.

J Pharm Biomed Anal 2020 Jun 18;189:113433. Epub 2020 Jun 18.

Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. Electronic address:

Therapeutic drug monitoring, which is the measurement of drug concentrations in the blood, is a useful tool to guide clinical decision-making and treatment adjustments, on the condition that drug concentrations are correlated with treatment response. For guselkumab, an anti-IL-23 monoclonal antibody for the treatment of moderate-to-severe psoriasis, such a concentration-response relationship could not yet be determined as no commercial assays for the quantification of this drug or antibodies against this drug are available. Therefore, the aim of this study was to develop and validate immunoassays for the quantification of guselkumab and anti-guselkumab antibodies according to the guidelines of the European Medicines Agency (EMA). Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113433DOI Listing

Human phase I in vitro liver metabolism of two bisphenolic diglycidyl ethers BADGE and BFDGE.

Toxicol Lett 2020 Jun 29. Epub 2020 Jun 29.

Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. Electronic address:

Root canal sealers are commonly used to endodontically treat teeth with periapical infections. Some root canal sealers based on epoxy resin contain bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE). The presence of these chemicals is of concern due to the close contact to the blood stream at the apex and the long setting times of up to 24 hours. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.06.022DOI Listing

Development, characterization and in vitro antioxidant activity of chitosan-coated alginate microcapsules entrapping Viola odorata Linn. extract.

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

Food Safety Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Viola odorata Linn or sweet violet has several biological activities due to the presence of flavonoids, tannins, alaloid, glycoside, and saponins. However, susceptibility of these compounds to harsh conditions and low solubility is a great challenge for their incorporation into food products. Therefore, encapsulation can be an effective approach in this respect. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.250DOI Listing

Increased putrescine levels due to ODC1 overexpression prevents mitochondrial dysfunction-related apoptosis induced by methylmercury.

Life Sci 2020 Jun 29:118031. Epub 2020 Jun 29.

Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan; Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. Electronic address:

Aims: We had previously reported that addition of putrescine to the culture medium was reported to reduce methylmercury toxicity in C17.2 neural stem cells. Here, we have examined the inhibition of methylmercury-induced cytotoxicity by putrescine using ODC1-overexpressing C17. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118031DOI Listing

Prevalence and risk factors associated with human cystic echinococcosis in rural areas, Mongolia.

PLoS One 2020 2;15(7):e0235399. Epub 2020 Jul 2.

Department of Biology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.

Cystic echinococcosis is a chronic, complex and neglected zoonotic disease with considerable socio-economic impact on the affected population. Even though Mongolia is included in the list of high cystic echinococcosis risk countries, there has been very limited research and evidence on the prevalence or prevention of cystic echinococcosis. This field-based cross-sectional study to investigate the prevalence of cystic echinococcosis and its potential risk factors in Mongolia was conducted from April 2016 to March 2018. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235399PLOS

An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research.

Altern Lab Anim 2020 Jul 2:261192920929701. Epub 2020 Jul 2.

Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.

Prostate cancer is one of the most commonly diagnosed cancers worldwide, particularly in elderly populations. To mitigate the expected increase in prostate cancer-related morbidity and mortality as a result of an expanding aged population, safer and more effective therapeutics are required. To this end, plenty of research is focusing on the mechanisms underlying cancer initiation and development, the metastatic process and on the discovery of new therapies. Read More

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http://dx.doi.org/10.1177/0261192920929701DOI Listing

Male-Specific Metabolic Considerations Concerning the Prescription of Second-Generation Antipsychotics to Adolescents.

J Child Adolesc Psychopharmacol 2020 Jun 30. Epub 2020 Jun 30.

Clinical Psychology and Psychotherapy, University of Zurich, Zurich, Switzerland.

Although males and females gain comparable weight when prescribed second-generation antipsychotics (SGAs), males may be uniquely vulnerable to an array of endocrinological, inflammatory, and psychosocial adverse drug effects. This opinion piece reviews work in each of these three areas for consideration. Androgens may decrease both through hypothalamic-pituitary-gonadal axis dysregulation and as a consequence of increased adiposity. Read More

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http://dx.doi.org/10.1089/cap.2020.0052DOI Listing

Combination treatment with secukinumab and dimethyl fumarate in a patient with psoriasis and recent diagnosis of multiple sclerosis.

Dermatol Ther 2020 Jul 2:e13943. Epub 2020 Jul 2.

Dermatology Unit; Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine; University of Modena and Reggio Emilia, Modena, Italy.

The therapeutic approach to patients with psoriasis and concomitant multiple sclerosis is challenging. We report the clinical case of a 44-year-old man affected by psoriasis and psoriatic arthritis treated with secukinumab for 2 years, who received also dimethyl fumarate because of a recent diagnosis of relapsing remitting multiple sclerosis. Moreover, a mini-review of the available literature regarding the use of secukinumab in patients with psoriasis or ankylosing spondylitis and coexisting central nervous system demyelinating diseases was performed. Read More

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http://dx.doi.org/10.1111/dth.13943DOI Listing

Computational Identification of Kinases That Control Axon Growth in Mouse.

SLAS Discov 2020 Jul 2:2472555220930697. Epub 2020 Jul 2.

Department of Computer Science, University of Miami, Miami, FL, USA.

The determination of signaling pathways and transcriptional networks that control various biological processes is a major challenge from both basic science and translational medicine perspectives. Because such analysis can point to critical disease driver nodes to target for therapeutic purposes, we combined data from phenotypic screening experiments and gene expression studies of mouse neurons to determine information flow through a molecular interaction network using a network propagation approach. We hypothesized that differences in information flow between control and injured conditions prioritize relevant driver nodes that cause this state change. Read More

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http://dx.doi.org/10.1177/2472555220930697DOI Listing

Risk factors of postoperative delayed wound healing in patients with rheumatoid arthritis treated with a biological agent.

Mod Rheumatol 2020 Jul 2:1-14. Epub 2020 Jul 2.

Department of Orthopedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Objectives: This retrospective study aimed to investigate the risk factors associated with delayed wound healing (DWH) after orthopedic surgery in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs).

Methods: We reviewed medical records of 276 orthopedic procedures for 187 RA patients treated with bDMARDs. As a preoperative nutritional status assessment, we evaluated body mass index (BMI), prognostic nutritional index (PNI), and controlling nutritional status (CONUT). Read More

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http://dx.doi.org/10.1080/14397595.2020.1790138DOI Listing

Density Functional Theory Based Methods for the Calculation of X-ray Spectroscopy.

Acc Chem Res 2020 Jul 2. Epub 2020 Jul 2.

School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.

ConspectusThe availability of new light sources combined with the realization of the unique capabilities of spectroscopy in the X-ray region has driven tremendous advances in the field of X-ray spectroscopy. Currently, these techniques are emerging as powerful analytical tools for the study of a wide range of problems encompassing liquids, materials, and biological systems. Time-resolved measurements add a further dimension to X-ray spectroscopy, opening up the potential to resolve ultrafast chemical processes at an atomic level. Read More

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http://dx.doi.org/10.1021/acs.accounts.0c00171DOI Listing

Purple Tulip Extract improves signs of skin aging through dermal structural modulation as shown by genomic, protein expression and skin appearance of volunteers studied.

J Cosmet Dermatol 2020 Jul 2. Epub 2020 Jul 2.

D.I.V.A. Expertise, Toulouse, France.

Background: Purple tulip extract is a rich source of flavonoids which are powerful antioxidants and can hence be considered as an ideal candidate for use in skin care products.

Objectives: We aimed to evaluate the effects of purple tulip extract on skin quality and to determine its molecular modes of interaction.

Methods: A pangenomic study on human skin fibroblasts was carried out to analyse multiple changes in gene expression. Read More

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http://dx.doi.org/10.1111/jocd.13583DOI Listing

Structural studies on the endocrine-disrupting role of polybrominated diphenyl ethers (PBDEs) in thyroid diseases.

Environ Sci Pollut Res Int 2020 Jul 1. Epub 2020 Jul 1.

King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah, 21589, Saudi Arabia.

Polybrominated diphenyl ethers (PBDEs) are synthetic brominated flame retardants with extensive applications in daily-life consumer products. However, PBDEs have become ubiquitous environmental contaminants due to their leach-out capability. The hazardous human health effects and endocrine-disrupting activity of PBDEs have led many governmental organizations to impose ban on their manufacture, causing their gradual phase out from commercial products. Read More

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http://dx.doi.org/10.1007/s11356-020-09913-8DOI Listing

Botanical preparation HX109 inhibits macrophage-mediated activation of prostate epithelial cells through the CCL4-STAT3 pathway: implication for the mechanism underlying HX109 suppression of prostate hyperplasia.

Heliyon 2020 Jun 23;6(6):e04267. Epub 2020 Jun 23.

Helixmith Co. Ltd., 21, Magokjungang 8-ro 7-gil, Gangseo-gu, Seoul, 07794, Republic of Korea.

Benign prostatic hyperplasia (BPH) is one of the most frequently observed diseases in the elderly male population worldwide. A variety of factors such as aging, hormonal imbalance, chronic inflammation, and oxidative stress play an important role in its pathogenesis. We have previously shown that HX109, an ethanol extract prepared from 3 plants (, , and ), alleviates prostate hyperplasia in the BPH rat model and suppresses AR signaling by upregulating Ca/CAMKKβ and ATF3. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322056PMC

RIPK3: A New Player in Renal Fibrosis.

Front Cell Dev Biol 2020 16;8:502. Epub 2020 Jun 16.

Kolling Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

Chronic kidney disease (CKD) is the end result of a plethora of renal insults, including repeated episodes of acute or toxic kidney injury, glomerular, or diabetic kidney disease. It affects a large number of the population worldwide, resulting in significant personal morbidity and mortality and economic cost to the community. Hence it is appropriate to focus on treatment strategies that interrupt the development of kidney fibrosis, the end result of all forms of CKD, in addition to upstream factors that may be specific to certain diseases. Read More

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http://dx.doi.org/10.3389/fcell.2020.00502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308494PMC

A novel bacterial β--acetyl glucosaminidase from possessing transglycosylation and reverse hydrolysis activities.

Biotechnol Biofuels 2020 29;13:115. Epub 2020 Jun 29.

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211800 People's Republic of China.

Background: -Acetyl glucosamine (GlcNAc) and -Acetyl chitooligosaccharides (-Acetyl COSs) exhibit many biological activities, and have been widely used in the pharmaceutical, agriculture, food, and chemical industries. Particularly, higher -Acetyl COSs with degree of polymerization from 4 to 7 ((GlcNAc)-(GlcNAc)) show good antitumor and antimicrobial activity, as well as possessing strong stimulating activity toward natural killer cells. Thus, it is of great significance to discover a β--acetyl glucosaminidase (NAGase) that can not only produce GlcNAc, but also synthesize -Acetyl COSs. Read More

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http://dx.doi.org/10.1186/s13068-020-01754-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324980PMC

Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice.

Stem Cells Int 2020 13;2020:9054514. Epub 2020 Jun 13.

Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss. However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare. ADSCs exert biological functions via the paracrine actions of various growth factors and cytokines. Read More

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http://dx.doi.org/10.1155/2020/9054514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306841PMC

Microvesicles from Human Immortalized Cell Lines of Endothelial Progenitor Cells and Mesenchymal Stem/Stromal Cells of Adipose Tissue Origin as Carriers of Bioactive Factors Facilitating Angiogenesis.

Stem Cells Int 2020 15;2020:1289380. Epub 2020 Jun 15.

Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland.

Endothelial progenitor cells (EPCs) and mesenchymal stem/stromal cells (MSCs) are associated with maintaining tissue homeostasis and tissue repair. Both types of cells contribute to tissue regeneration through the secretion of trophic factors (alone or in the form of microvesicles). This study investigated the isolation and biological properties of microvesicles (MVs) derived from human immortalized MSC line HATMSC1 of adipose tissue origin and EPC line. Read More

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http://dx.doi.org/10.1155/2020/1289380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312709PMC

Boundary line models for soil nutrient concentrations and wheat yield in national-scale datasets.

Eur J Soil Sci 2020 May 15;71(3):334-351. Epub 2019 Nov 15.

British Geological Survey Nottingham UK.

In boundary line analysis a biological response (e.g., crop yield) is assumed to be a function of a variable (e. Read More

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http://dx.doi.org/10.1111/ejss.12891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318209PMC

Rheumatoid Arthritis as a Risk Factor for Coronary Artery Calcification and Obstructive Coronary Artery Disease in Patients with Chest Pain: A Registry Based Cross-Sectional Study.

Clin Epidemiol 2020 24;12:679-689. Epub 2020 Jun 24.

Department of Cardiology, Hospital Unit West, Herning, Denmark.

Purpose: To examine the occurrence and severity of coronary artery disease (CAD) in patients with rheumatoid arthritis (RA) compared to non-RA patients in a population referred for coronary computed tomography angiography (CTA) due to chest pain.

Patients And Methods: In this cross-sectional study, 46,210 patients from a national CTA database were included. Patients with RA were stratified on serology, treatment with conventional synthetic or biological disease-modifying antirheumatic drugs (DMARDs), and the need for relapse or flare treatment with intraarticular or -muscular glucocorticoid injections (GCIs). Read More

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http://dx.doi.org/10.2147/CLEP.S251168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322143PMC

Multigenerational exposure to elevated temperatures leads to a reduction in standard metabolic rate in the wild.

Funct Ecol 2020 Jun 19;34(6):1205-1214. Epub 2020 Feb 19.

Institute of Biodiversity, Animal Health, and Comparative Medicine University of Glasgow Glasgow UK.

In light of global climate change, there is a pressing need to understand and predict the capacity of populations to respond to rising temperatures. Metabolic rate is a key trait that is likely to influence the ability to cope with climate change. Yet, empirical and theoretical work on metabolic rate responses to temperature changes has so far produced mixed results and conflicting predictions. Read More

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http://dx.doi.org/10.1111/1365-2435.13538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318562PMC

Seasons of .

Limnol Oceanogr 2020 May 19;65(5):1085-1102. Epub 2019 Nov 19.

Biology Department Woods Hole Oceanographic Institution Woods Hole Massachusetts.

is a widespread and important marine primary producer. Time series provide critical information for identifying and understanding the factors that determine abundance patterns. Here, we present the results of analysis of a 16-yr hourly time series of at the Martha's Vineyard Coastal Observatory, obtained with an automated, in situ flow cytometer. Read More

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http://dx.doi.org/10.1002/lno.11374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319482PMC

Leveraging preclinical models for the development of Alzheimer disease therapeutics.

Nat Rev Drug Discov 2020 Jul 8;19(7):447-462. Epub 2020 Apr 8.

Denali Therapeutics, South San Francisco, CA, USA.

A large number of mouse models have been engineered, characterized and used to advance biomedical research in Alzheimer disease (AD). Early models simply damaged the rodent brain through toxins or lesions. Later, the spread of genetic engineering technology enabled investigators to develop models of familial AD by overexpressing human genes such as those encoding amyloid precursor protein (APP) or presenilins (PSEN1 or PSEN2) carrying mutations linked to early-onset AD. Read More

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http://dx.doi.org/10.1038/s41573-020-0065-9DOI Listing

Novel candidate drugs in anti-tumor necrosis factor refractory Crohn's diseases: in silico study for drug repositioning.

Sci Rep 2020 Jul 1;10(1):10708. Epub 2020 Jul 1.

Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, 892 Dongnam-ro, Gandong-gu, Seoul, 05278, Republic of Korea.

Biologicals like anti-tumor necrosis factor (TNF) therapy for Crohn's disease (CD) are safe and effective but there is a significant rate of primary and secondary nonresponse in the patients. In this study, we applied a computational approach to discover novel drug therapies for anti-TNF refractory CD in silico. We use a transcriptome dataset (GSE100833) for the anti-TNF refractory CD patients from NCBI GEO. Read More

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http://dx.doi.org/10.1038/s41598-020-67801-0DOI Listing

Impact of immune-mediated diseases in inflammatory bowel disease and implications in therapeutic approach.

Sci Rep 2020 Jul 1;10(1):10731. Epub 2020 Jul 1.

Gastroenterology Department, Marques de Valdecilla University Hospital - IDIVAL, Santander, Cantabria, Spain.

Inflammatory bowel diseases (IBD) belong to the group of immune-mediated diseases (IMIDs). The effect of associated IMIDs in the prognosis in IBD is nowadays unknown. To describe IMIDs associated to IBD patients and evaluate differences linked to the presence or absence of IMIDs. Read More

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http://dx.doi.org/10.1038/s41598-020-67710-2DOI Listing

Dual Roles of PU.1 in the Expression of PD-L2: Direct Transactivation with IRF4 and Indirect Epigenetic Regulation.

J Immunol 2020 Jul 1. Epub 2020 Jul 1.

Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; and

PD-L2, which has been identified as a PD-1 ligand, is specifically expressed in dendritic cells (DCs) and macrophages. The transcription factors that determine the cell type-specific expression of PD-L2 are largely unknown, although PD-1 and its ligands, which have been shown to play important roles in T cell suppression, have been vigorously analyzed in the field of cancer immunology. To reveal the mechanism by which gene expression is regulated, we focused on DCs, which play key roles in innate and acquired immunity. Read More

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http://dx.doi.org/10.4049/jimmunol.1901008DOI Listing

Trauma and violent offending among adolescents: a birth cohort study.

J Epidemiol Community Health 2020 Jul 1. Epub 2020 Jul 1.

Population Research Unit, Faculty of Social Science, University of Helsinki, Helsinki, Finland.

Background: Earlier studies, based on data collected among juvenile court clients or prisoners, suggest that there is an association between trauma and adolescent-onset offending. However, there is a lack of large-scale data on juvenile violence and clinical mental health observations with unselected participants, and a risk-factor-oriented research combining multiple variables affecting violent behaviour.

Methods: We analyse the effect of trauma on violent offending using longitudinal register-linkage population data. Read More

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http://dx.doi.org/10.1136/jech-2020-214188DOI Listing

RNA polymerase III transcription as a disease factor.

Genes Dev 2020 Jul;34(13-14):865-882

Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.

RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in eukaryotic cells, whose RNA products have well-defined functions in translation and other biological processes for some, and functions that remain to be defined for others. For all of them, however, new functions are being described. For example, Pol III products have been reported to regulate certain proteins such as protein kinase R (PKR) by direct association, to constitute the source of very short RNAs with regulatory roles in gene expression, or to control microRNA levels by sequestration. Read More

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http://dx.doi.org/10.1101/gad.333989.119DOI Listing

Validation of a new software eAT24 used to assess dietary intake in the adult Portuguese population.

Public Health Nutr 2020 Jul 2:1-11. Epub 2020 Jul 2.

Faculty of Nutrition and Food Sciences, University of Porto, 4200-465Porto, Portugal.

Objective: The aim of the current study was to evaluate the accuracy of the new software eAT24 used to assess dietary intake in the National Food, Nutrition and Physical Activity Survey (IAN-AF) against urinary biomarkers: N (nitrogen), K (potassium) and Na (sodium).

Design: We conducted a cross-sectional study. Two non-consecutive 24-h dietary recalls (24-HDR) were applied, and a 24-h urine sample was collected. Read More

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http://dx.doi.org/10.1017/S1368980020001044DOI Listing

A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment.

J Neuroinflammation 2020 Jul 1;17(1):200. Epub 2020 Jul 1.

Department of Neural Engineering and Biological Interdisciplinary Studies, Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, 27 Taiping Road, Haidian District, Beijing, 100850, China.

Background: Astrocytes are crucial regulators in the central nervous system. Abnormal activation of astrocytes contributes to some behavior deficits. However, mechanisms underlying the effects remain unclear. Read More

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http://dx.doi.org/10.1186/s12974-020-01871-9DOI Listing

Glutantβase: a database for improving the rational design of glucose-tolerant β-glucosidases.

BMC Mol Cell Biol 2020 Jul 1;21(1):50. Epub 2020 Jul 1.

Laboratory of Bioinformatics and Systems. Department of Computer Science, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil.

Β-glucosidases are key enzymes used in second-generation biofuel production. They act in the last step of the lignocellulose saccharification, converting cellobiose in glucose. However, most of the β-glucosidases are inhibited by high glucose concentrations, which turns it a limiting step for industrial production. Read More

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http://dx.doi.org/10.1186/s12860-020-00293-yDOI Listing

Biopolymeric, Nanopatterned, Fibrous Carriers for Wound Healing Applications.

Curr Pharm Des 2020 Jul 1. Epub 2020 Jul 1.

Chitkara College of Pharmacy, Chitkara University, Punjab. India.

Background: Any sort of wound injury leads to skin integrity and further leads to the wound formation. Million of deaths are reported every year which contributes as an economical hamper world widely, this accounts for 10% of death rate that insight into various diseases. Current methodology: Rapid wound healing plays an important role for effective health care. Read More

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http://dx.doi.org/10.2174/1381612826666200701152217DOI Listing

Bioprospecting of Nitrogenous Heterocyclic Scaffolds with Potential Action for Neglected Parasitosis: A Review.

Curr Pharm Des 2020 Jul 1. Epub 2020 Jul 1.

Universidade Estadual da Paraíba, R. Baraúnas, 351, Cidade Universitária, Campina Grande, Paraíba, 58429-500. Brazil.

Neglected parasitic diseases are a group of infections currently considered as a worldwide concern. This fact can be attributed to the migration of these diseases to developed and developing countries, associated with therapeutic insufficiency resulted from the low investment in the research and development of new drugs. In order to overcome this situation, bioprospecting supports medicinal chemistry in the identification of new scaffolds with therapeutically appropriate physicochemical and pharmacokinetic properties. Read More

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http://dx.doi.org/10.2174/1381612826666200701160904DOI Listing

Biological investigations on therapeutic effect of chitosan encapsulated nano resveratrol against gestational diabetes mellitus rats induced by streptozotocin.

Drug Deliv 2020 Dec;27(1):953-963

Center of Prenatal Diagnosis, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, PR China.

The chitosan encapsulation with bioactive compounds (resveratrol) is a significant method that can be used to raise the stability and effectiveness of substances in gestational diabetes management. In this study, the resveratrol-zinc oxide complex is encapsulated with chitosan (CS-ZnO-RS). The synthesized CS-ZnO-RS could be used to deliver the resveratrol with minimized side effects and also improved bioavailability. Read More

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http://dx.doi.org/10.1080/10717544.2020.1775722DOI Listing
December 2020

Introduction to Focus Issue: Symmetry and optimization in the synchronization and collective behavior of complex systems.

Chaos 2020 Jun;30(6):060401

Clarkson Center for Complex Systems Science, Potsdam, New York 13699, USA.

Synchronization phenomena and collective behavior are commonplace in complex systems with applications ranging from biological processes such as coordinated neuron firings and cell cycles to the stability of alternating current power grids. A fundamental pursuit is the study of how various types of symmetry-e.g. Read More

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http://dx.doi.org/10.1063/5.0016491DOI Listing

Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis.

Org Lett 2020 Jul 17;22(13):4970-4973. Epub 2020 Jun 17.

Laboratory of Organometallic Synthesis, Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland.

The synthesis of functionalized α,β-unsaturated sulfonamides by means of cross-metathesis of vinyl sulfonamides and olefins has been developed. The reaction proceeds smoothly in the presence of Hoveyda-Grubbs catalyst and its nitro analogue, providing a wide range of substituted products. The usefulness of this methodology has been proven in the preparation of new derivatives of biologically active ingredients, moxifloxacin and naratriptan. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01471DOI Listing

Global Transcriptomic Responses of Strain RA in Media Supplemented with Beechwood Xylan.

Microorganisms 2020 Jun 29;8(7). Epub 2020 Jun 29.

Faculty of Science, Universiti Teknologi Malaysia, Johor 81310, Malaysia.

The majority of the members in order are underexplored prokaryotic extremophiles. , a new genus within , was first described in 2019. is the only species in this genus. Read More

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http://dx.doi.org/10.3390/microorganisms8070976DOI Listing

Critical Factors Involved in Primordia Building in : A Review.

Molecules 2020 Jun 29;25(13). Epub 2020 Jun 29.

Plant Breeding, Wageningen University and Research, PO Box 386. 6700AJ Wageningen, The Netherlands.

The button mushroom is an economically important crop worldwide. Many aspects of its cultivation are well known, except for the precise biological triggers for its fructification. By and large, for most basidiomycete species, nutrient availability, light and a drop in temperature are critical factors for fructification. Read More

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http://dx.doi.org/10.3390/molecules25132984DOI Listing

Genetic Variants in the and Genes Mapping in the Beta and Gamma Nodules of the Fibrinogen Molecule in Congenital Quantitative Fibrinogen Disorders Associated with a Thrombotic Phenotype.

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

National Center of Hemostasis and Thrombosis, Department of Hematology and Transfusiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, 03601 Martin, Slovakia.

Fibrinogen is a hexameric plasmatic glycoprotein composed of pairs of three chains (Aα, Bβ, and γ), which play an essential role in hemostasis. Conversion of fibrinogen to insoluble polymer fibrin gives structural stability, strength, and adhesive surfaces for growing blood clots. Equally important, the exposure of its non-substrate thrombin-binding sites after fibrin clot formation promotes antithrombotic properties. Read More

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http://dx.doi.org/10.3390/ijms21134616DOI Listing

HMGB1-Mediated Neuroinflammatory Responses in Brain Injuries: Potential Mechanisms and Therapeutic Opportunities.

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

Neuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor 47500, Malaysia.

Brain injuries are devastating conditions, representing a global cause of mortality and morbidity, with no effective treatment to date. Increased evidence supports the role of neuroinflammation in driving several forms of brain injuries. High mobility group box 1 (HMGB1) protein is a pro-inflammatory-like cytokine with an initiator role in neuroinflammation that has been implicated in Traumatic brain injury (TBI) as well as in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Read More

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http://dx.doi.org/10.3390/ijms21134609DOI Listing

Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity.

Cancers (Basel) 2020 Jun 29;12(7). Epub 2020 Jun 29.

Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.

Plants are an important source of chemically diverse natural products that target microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel, and vinca alkaloids are the earliest plant-derived microtubule-targeting agents (MTAs), and paclitaxel and vinca alkaloids are currently important drugs used in the treatment of cancer. Several additional plant-derived compounds that act on microtubules with improved anticancer activity are at varying stages of development. Read More

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http://dx.doi.org/10.3390/cancers12071721DOI Listing

Heterologous Expression of Dehydration-Inducible of Confers Drought and Salt Tolerance in .

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

Department of Plant Sciences, University of California Davis, Davis, CA 95616, USA.

As the only woody resurrection plant, Myrothamnus flabellifolia has a strong tolerance to drought and can survive long-term in a desiccated environment. However, the molecular mechanisms related to the stress tolerance of are largely unknown, and few tolerance-related genes previously identified had been functionally characterized. WRKYs are a group of unique and complex plant transcription factors, and have reported functions in diverse biological processes, especially in the regulation of abiotic stress tolerances, in various species. Read More

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http://dx.doi.org/10.3390/ijms21134603DOI Listing
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