3,764,699 results match your criteria Biologicals : journal of the International Association of Biological Standardization[Journal]


Synergistic antibacterial mechanism of BiTe nanoparticles combined with the ineffective β-lactam antibiotic cefotaxime against methicillin-resistant Staphylococcus aureus.

J Inorg Biochem 2019 Apr 12;196:110687. Epub 2019 Apr 12.

Research Center for Environmental Ecology and Engineering, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, No. 206, Guanggu First Road, Wuhan 430073, PR China. Electronic address:

Methicillin-resistant Staphylococcus aureus (MRSA) infections have become a serious threat to public health because traditional antibiotics are less efficient. Here, we developed a simple and efficient combination of BiTe nanoparticles (NPs) with β-lactam antibiotics cefotaxime (CTX), which presented significant synergistic antibacterial activity against MRSA. The minimal inhibitory concentration of CTX decreased from 256 to 32 μg/mL in the presence of 8 μg/mL BiTe NPs. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.04.001DOI Listing

A Microparticle Approach for Non-viral Gene Delivery within 3D Human Mesenchymal Stromal Cell Aggregates.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706, USA; Materials Science Program, University of Wisconsin, Madison, WI 53706, USA; Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI 53705, USA; AO Foundation Collaborative Research Center, Davos, Switzerland. Electronic address:

Three-dimensional (3D) multicellular aggregates, in comparison to two-dimensional monolayer culture, can provide tissue culture models that better recapitulate the abundant cell-cell and cell-matrix interactions found in vivo. In addition, aggregates are potentially useful building blocks for tissue engineering. However, control over the interior aggregate microenvironment is challenging due to inherent barriers for diffusion of biological mediators (e. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.038DOI Listing

Synergism of open chromatin regions involved in regulating genes in Bombyx mori.

Insect Biochem Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

Biological Science Research Center, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing 400715, China. Electronic address:

The dynamic variability of transcription factors (TFs) and their binding sites makes it challenging to conduct genome-wide transcription regulation research. The silkworm Bombyx mori, which produces silk, is one of the most valuable model insects in the order Lepidoptera. The "opening" and "closing" of chromatin in different silk yield strains is associated with changes in silk production, making this insect a good model for studying the transcriptional regulation of genes. Read More

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http://dx.doi.org/10.1016/j.ibmb.2019.04.014DOI Listing

Dual role of autophagy/mitophagy in chronic obstructive pulmonary disease.

Pulm Pharmacol Ther 2019 Apr 17. Epub 2019 Apr 17.

Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Chronic obstructive pulmonary disease (COPD) is a common lung disease characterised by progressive, irreversible airflow limitation. Multiple regulatory pathways are involved in COPD pathogenesis. Emerging evidence from clinical and basic medical research has suggested that autophagy-a highly conserved catabolic process mediated under various cellular stress conditions-plays a role in the development and prognosis of COPD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10945539183024
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http://dx.doi.org/10.1016/j.pupt.2019.04.002DOI Listing
April 2019
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Role of astrocytes-derived D-serine in PFOS-induced neurotoxicity through NMDARs in the rat primary hippocampal neurons.

Toxicology 2019 Apr 17. Epub 2019 Apr 17.

Department of Environmental Health and Toxicology, School of Public Health, Dalian Medical University, Dalian 116044, China; Dalian Key Laboratory of Hematology, Liaoning Hematopoietic Stem Cell Transplantation Medical Center, Department of Environmental Health and Toxicology, School of Public Health, Dalian Medical University. Dalian, Liaoning, 116044, China. Electronic address:

Perfluorooctane sulfonate (PFOS) is one of the perfluorinated compounds (PFCs), and has been used in industrial and consumer products. It has already been shown that PFOS could be detected in the environmental media and biological species including humans, due to its resistance to environmental degradation. PFOS is known to induce a series of adverse impacts on human health, e. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.007DOI Listing

An optimized cocktail of chitinolytic enzymes to produce N,N'-diacetylchitobiose and N-acetyl-d-glucosamine from defatted krill by-products.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Fine Chemical Engineering and School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China; Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:

Defatted krill powder (DKP), the byproduct of krill oil industry, is a resource of biological macromolecules. Here, one bacterial protease, three bacterial chitinases and one insect N-acetyl-d-hexosaminidase were integratively used to produce peptide, N,N'-diacetylchitobiose [(GlcNAc)] and N-acetyl-d-glucosamine (GlcNAc) from DKP. First, alkaline protease was found to outperform neutral protease in deproteinizing DKP and the resultant krill peptides were rich in essential amino acids (41. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.114DOI Listing

Phytoplankton growth and stoichiometric responses to warming, nutrient addition and grazing depend on lake productivity and cell size.

Glob Chang Biol 2019 Apr 20. Epub 2019 Apr 20.

Department of Aquatic Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB, Wageningen, Netherlands.

Global change involves shifts in multiple environmental factors that act in concert to shape ecological systems in ways that depend on local biotic and abiotic conditions. Little is known about the effects of combined global change stressors on phytoplankton communities, and particularly how these are mediated by distinct community properties such as productivity, grazing pressure and size distribution. Here, we tested for the effects of warming and eutrophication on phytoplankton net growth rate and C:N:P stoichiometry in two phytoplankton cell size fractions (<30μm and >30μm) in the presence and absence of grazing in microcosm experiments. Read More

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http://dx.doi.org/10.1111/gcb.14660DOI Listing

Clinical response correlates with 4-week post injection ustekinumab concentrations in moderate-to-severe psoriasis patients.

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, Ghent University Hospital, Ghent, Belgium.

Background: Cost-effective use of biologicals is becoming increasingly important. Monitoring drug concentrations has emerged as a valuable tool to guide clinical decision-making as drug concentrations have been linked to clinical outcomes. The presence of a concentration-response relationship for ustekinumab at trough is uncertain due to the contradictory results reported. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18016
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http://dx.doi.org/10.1111/bjd.18016DOI Listing
April 2019
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Rapid detection of Escherichia coli in beverages using genetically engineered bacteriophage T7.

AMB Express 2019 Apr 19;9(1):55. Epub 2019 Apr 19.

Department of Food Science and Technology, University of California, Davis, CA, USA.

Foodborne illness due to bacterial contamination is a significant issue impacting public health that demands new technology which is practical to implement by food industry. Detection of bacteria in food products and production facilities is a crucial strategy supporting food safety assessments. Bacteriophages were investigated as a tool for bacterial detection due to their ability to infect specific strain of host bacteria in order to improve sensitivity, specificity, and rapidity of bacterial detection. Read More

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https://amb-express.springeropen.com/articles/10.1186/s13568
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http://dx.doi.org/10.1186/s13568-019-0776-7DOI Listing
April 2019
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Vapor Phase Hydrogen Peroxide Uptake by Silicone Tubing and Primary Packaging Components during Protein Drug Product Aseptic Filling: Impact by Pre-treatment and Sterilization Process.

PDA J Pharm Sci Technol 2019 Apr 19. Epub 2019 Apr 19.

Genentech.

In the vapor phase hydrogen peroxide (VPHP)-sanitized environment, VPHP uptake by product-contacting components could eventually lead to undesired oxidation of biological drug products. Silicone tubing and primary packaging materials are prominent examples of such product-contacting surfaces that are typically processed/sterilized prior to use. This study investigated the VPHP-uptake tendency of these components and how their respective processing/sterilization methods affect uptake behaviors. Read More

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http://dx.doi.org/10.5731/pdajpst.2019.009928DOI Listing

A Clinical Applicable Gene Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Molecular Biology, Genentech Inc.

Purpose: Four consensus molecular subtypes (CMS1-4) of colorectal cancer (CRC) were identified in primary tumors and found to be associated with distinctive biological features and clinical outcomes. Given that distant metastasis largely accounts for CRC-related mortality, we examined the molecular and clinical attributes of CMS in metastatic CRC (mCRC).

Experimental Design: We developed a CRC-focused Nanostring based CMS classifier that is ideally suited to interrogate archival tissues. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3032DOI Listing
April 2019
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Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model.

ASN Neuro 2019 Jan-Dec;11:1759091419843393

1 Department of Pediatrics, Biological Sciences Division, The University of Chicago, IL, USA.

In humans, homozygous mutations in the TPP1 gene results in loss of tripeptidyl peptidase 1 (TPP1) enzymatic activity, leading to late infantile neuronal ceroid lipofuscinoses disease. Using a mouse model that targets the Tpp1 gene and recapitulates the pathology and clinical features of the human disease, we analyzed end-stage (4 months) transcriptional changes associated with lack of TPP1 activity. Using RNA sequencing technology, Tpp1 expression changes in the forebrain/midbrain and cerebellum of 4-month-old homozygotes were compared with strain-related controls. Read More

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http://dx.doi.org/10.1177/1759091419843393DOI Listing
April 2019
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Shedding New Light on The Role of ανβ3 and α5β1 Integrins in Rheumatoid Arthritis.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

The Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu Province, China Pharmaceutical University, Nanjing 210009, China.

ανβ3 and α5β1 are essential glycoproteins involved in the pathogenesis of rheumatoid arthritis (RA). Understanding of the role these integrins play in disease have been analyzed via description of cells-expressing ανβ3 and α5β1 and their mediators to trigger inflammation. ανβ3 and α5β1 facilitate cells-ECM and cell-cell communication, producing pro-inflammatory factors. Read More

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https://www.mdpi.com/1420-3049/24/8/1537
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http://dx.doi.org/10.3390/molecules24081537DOI Listing
April 2019
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Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community.

Metabolites 2019 Apr 18;9(4). Epub 2019 Apr 18.

Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E8, Canada.

The use of multiple omics techniques (i.e., genomics, transcriptomics, proteomics, and metabolomics) is becoming increasingly popular in all facets of life science. Read More

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https://www.mdpi.com/2218-1989/9/4/76
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http://dx.doi.org/10.3390/metabo9040076DOI Listing
April 2019
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Hierarchical Virtual Screening of Potential Insectides Inhibitors of Acetylcholinesterase and Juvenile Hormone from Temephos.

Pharmaceuticals (Basel) 2019 Apr 18;12(2). Epub 2019 Apr 18.

Postgraduate Program in-Network in Pharmaceutical Innovation, Federal University of Amapá, Macapá, AP 68902-280, Brazil.

(Linnaeus, 1762; Diptera: Culicidae) is the main vector transmitting viral diseases such as dengue fever, dengue haemorrhagic fever, urban yellow fever, zika and chikungunya. Worldwide, especially in the Americas and Brazil, many cases of dengue have been reported in recent years, which have shown significant growth. The main control strategy is the elimination of the vector, carried out through various education programs, to change human habits, but the most usual is biological control, together with environmental management and chemical control. Read More

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http://dx.doi.org/10.3390/ph12020061DOI Listing

Heritability estimates of individual psychological distress symptoms from genetic variation.

J Affect Disord 2019 Apr 8;252:413-420. Epub 2019 Apr 8.

Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea. Electronic address:

Background: Psychological distress symptoms are associated with an increased risk of psychiatric disorders and medical illness. Although psychological distress is influenced by environmental factors, such as socioeconomic status, lifetime events, or interpersonal relationships, substantial interindividual variation also exists. However, heritability and genetic determinants of distress are poorly understood. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.011DOI Listing

Removal of triclosan in a Fenton-like system mediated by graphene oxide: Reaction kinetics and ecotoxicity evaluation.

Sci Total Environ 2019 Mar 25;673:726-733. Epub 2019 Mar 25.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China. Electronic address:

As a typical nanomaterial, graphene oxide (GO) can be easily dispersed in water and may affect the aqueous environment. In this paper, the degradation of triclosan (TCS) in a Fenton-like system Fe/HO in GO aqueous solution was investigated. Interestingly, it was observed that GO at low concentration (2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193135
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http://dx.doi.org/10.1016/j.scitotenv.2019.03.354DOI Listing
March 2019
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3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages.

Acta Biomater 2019 Apr 16. Epub 2019 Apr 16.

i3S - Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

Chitosan (Ch) is used in different biomedical applications to promote tissue repair. However, tissue injury caused by biomaterial implantation lead to the release of danger signals that engage different inflammatory pathways on the host. Different implanted materials activate the inflammasome leading to the modulation of the immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193027
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http://dx.doi.org/10.1016/j.actbio.2019.04.035DOI Listing
April 2019
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Maternal hyperuricemia superimposed on maternal hypertension aggravates the risk of small-for-gestational-age fetus.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong 250021, China. Electronic address:

Aims: Small-for-gestational-age (SGA) fetus is an important public health issue because of its high mortality and long-term effects on health. Maternal hyperuricemia is associated with diverse adverse pregnant outcomes and neonatal disturbance. We aimed to evaluate whether maternal hyper-uric acid (HUA) is associated with the risk of SGA fetus and to explore whether it can modify the association between maternal hyper-blood pressure (HBP) and SGA fetus. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.033DOI Listing

Presence of actin binding motif in VgrG-1 toxin of Vibrio cholerae reveals the molecular mechanism of actin cross-linking.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, Nadia, West Bengal, India. Electronic address:

Type VI secretion systems (T6SS) plays a crucial role in Vibrio cholerae mediated pathogenicity. Tip of T6SS is homologous to gp27/gp5 complex or tail spike of T4 bacteriophage. VgrG-1 of V. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193115
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.026DOI Listing
April 2019
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Molecular impacts of photobiomodulation on bone regeneration: A systematic review.

Prog Biophys Mol Biol 2019 Apr 16. Epub 2019 Apr 16.

School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia. Electronic address:

Photobiomodulation (PBM) encompasses a light application aimed to increase healing process, tissue regeneration, and reducing inflammation and pain. PBM is specifically aimed to modify the expression of cellular molecules; however, PBM impacts on cellular and molecular pathways especially in bone regenerative medicine have been investigated in scattered different studies. The purpose of the current study is to systematically review evidence on molecular impact of PBM on bone regeneration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00796107193001
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http://dx.doi.org/10.1016/j.pbiomolbio.2019.04.005DOI Listing
April 2019
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Hypoxia alters splicing of the cancer associated Fas gene.

Exp Cell Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Immunology and Cell Biology, Vilnius University, Institute of Biotechnology, Vilnius, Lithuania. Electronic address:

The removal of introns from mRNA precursors (pre-mRNAs) is an essential step in eukaryotic gene expression. The splicing machinery heavily contributes to biological complexity and especially to the ability of cells to adapt to altered cellular conditions. Hypoxia also plays a key role in the pathophysiology of many disease states. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.04.015DOI Listing

Vacuum Induced Surface Freezing for the Freeze-Drying of the Human Growth Hormone: How does Nucleation Control Affect Protein Stability?

J Pharm Sci 2019 Apr 16. Epub 2019 Apr 16.

Standardisation Science, National Institute for Biological Standards and Control, Blanche Lane, Medicines & Healthcare products Agency, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK. Electronic address:

In the present work, the effect of controlled nucleation on the stability of human growth hormone (hGH) during freeze-drying has been investigated. More specifically, the vacuum induced surface freezing technique has been compared to conventional freezing, both with and without an annealing step. Size exclusion chromatography and cell-based potency assays have been used to characterize the formation of soluble aggregates and the biological activity of hGH, respectively. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.04.014DOI Listing

Isolation of ceramides from Tagetes patula L. yellow flowers and nematicidal activity of the fractions and pure compounds against cyst nematode, Heterodera zeae.

Chem Biodivers 2019 Apr 19. Epub 2019 Apr 19.

University of Karachi International Center for Chemical and Biological Sciences, International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry,, International Centre for Chemical and, Biological Sciences (ICCBS),, University of Karachi, Karachi -75270, 75270, Karachi, PAKISTAN.

Investigation of yellow flower extract of Tagetes patula L. led to the identification of an aggregate of five phytoceramides. Among them, (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxyeicosanoylamino]-8-en-1, 3, 4-eicosenetriol; (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxyheneicosanoylamino]-8-en-1, 3, 4-eicosenetriol; (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxydocosanoyl- amino]-8-en-1, 3, 4-eicosenetriol and (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxytricosanoylamino]-8-en-1, 3, 4-eicosenetriol were identified as new compounds and termed as tagetceramides, whereas (2S, 3S, 4R, 8E)-2-[(R)-2'-hydroxytetracosanoylamino]-8-en-1,3,4-eicosenetriol was a known ceramide. Read More

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http://dx.doi.org/10.1002/cbdv.201900092DOI Listing

Genetic landscape and macro-evolution of co-circulating Coxsackieviruses A and Vaccine-derived Polioviruses in the Democratic Republic of Congo, 2008-2013.

PLoS Negl Trop Dis 2019 Apr 19;13(4):e0007335. Epub 2019 Apr 19.

Biology of Enteric Viruses Unit, Institut Pasteur, Paris, France.

Enteroviruses (EVs) are among the most common viruses infecting humans worldwide but only a few Non-Polio Enterovirus (NPEV) isolates have been characterized in the Democratic Republic of Congo (DR Congo). Moreover, circulating vaccine-derived polioviruses (PVs) [cVDPVs] isolated during multiple outbreaks in DR Congo from 2004 to 2018 have been characterized so far only by the sequences of their VP1 capsid coding gene. This study was carried to i) investigate the circulation and genetic diversity of NPEV and polio vaccine isolates recovered from healthy children and Acute Flaccid Paralysis (AFP) patients, ii) evaluate the occurrence of genetic recombination among EVs belonging to the Enterovirus C species (including PVs) and iii) identify the virological factors favoring multiple emergences of cVDPVs in DR Congo. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007335DOI Listing

Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats.

Int J Med Mushrooms 2019 ;21(4):381-392

Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China.

We studied Phellinus lonicerinus to determine the cytotoxic effect and the dual estrogenic activities of methyl-hispolon and their relation to estrogen signals in vivo and in vitro. The Glide scores of methyl-hispolon-estrogen receptor α (ERα) and methyl-hispolon-ERβ docked complexes were -7.29 kcal/mol and -6. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030355DOI Listing
January 2019

Asymmetric synthesis of natural and unnatural dibenzylbutane lignans from a common intermediate.

J Org Chem 2019 Apr 19. Epub 2019 Apr 19.

Lignans are a structurally diverse class of natural products with extensive pharmacological effects. Here we report the syntheses of both natural and unnatural dibenzylbutane lignans from a common intermediate which is prepared in five steps from known materials. Derivatization of this intermediate affords lignans featuring contiguous stereocenters in high diastereomeric purity after chromatography. Read More

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http://dx.doi.org/10.1021/acs.joc.9b00633DOI Listing

Responses of soil carbon sequestration to climate smart agriculture practices: A meta-analysis.

Glob Chang Biol 2019 Apr 19. Epub 2019 Apr 19.

Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY, 40546, USA.

Climate-smart agriculture (CSA) management practices (e.g., conservation tillage, cover crops, and biochar applications) have been widely adopted to enhance soil organic carbon (SOC) sequestration and to reduce greenhouse gas emissions while ensuring crop productivity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/gcb.14658
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http://dx.doi.org/10.1111/gcb.14658DOI Listing
April 2019
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Effect of electrochemotherapy with betulinic acid or cisplatin on regulation of heat shock proteins in metastatic human carcinoma cells in vitro.

Oncol Rep 2019 Apr 8. Epub 2019 Apr 8.

Department of Molecular and Cellular Biology, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, 50‑556 Wroclaw, Poland.

Betulinic acid (BTA) is naturally occurring triterpene that has received interest as a novel therapeutic substance with cytotoxicity towards a number of cancer cell lines. Despite the wide spectrum of biological and pharmacological effects, its effect may be limited its lipophobic properties. Therefore, strategies to improve the access of BTA to the cells are required to enhance the anticancer effects. Read More

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http://dx.doi.org/10.3892/or.2019.7103DOI Listing

miR‑145‑5p is associated with pathological complete response to neoadjuvant chemotherapy and impairs cell proliferation by targeting TGFβR2 in breast cancer.

Oncol Rep 2019 Apr 5. Epub 2019 Apr 5.

Genomics Sciences Program, Autonomous University of Mexico City, Mexico City 03100, Mexico.

Cancer patients who better benefit from neoadjuvant chemotherapy (NeoCh) are those who achieve a successful pathological complete response (pCR) represented by the absence of residual disease. Unfortunately, no highly sensitive and specific tumor biomarkers for predicting the clinical response to NeoCh have yet been defined. The aim of the present study was to ascertain whether miR‑145‑5p could discriminate between pCR and no‑pCR in triple‑negative breast cancer patients that received a cisplatin/doxorubicin‑based neoadjuvant treatment. Read More

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http://dx.doi.org/10.3892/or.2019.7102DOI Listing

Impact of Changing Treatment Strategies on Outcomes in Pediatric Ulcerative Colitis.

Inflamm Bowel Dis 2019 Apr 19. Epub 2019 Apr 19.

Department of Gastroenterology & Clinical Nutrition, The Royal Children's Hospital Melbourne, Australia.

Background: In recent years, treatment strategies for ulcerative colitis have evolved with an early step-up approach, the availability of biologicals, and therapeutic drug monitoring.We carried out this study to evaluate the effect of these changes on disease outcomes.

Methods: In this retrospective review, 2 time periods were defined: Group 1 (2005-2010) and Group 2 (2011-2016). Read More

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https://academic.oup.com/ibdjournal/advance-article/doi/10.1
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http://dx.doi.org/10.1093/ibd/izz072DOI Listing
April 2019
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Association of Peritumoral Radiomics With Tumor Biology and Pathologic Response to Preoperative Targeted Therapy for HER2 (ERBB2)-Positive Breast Cancer.

JAMA Netw Open 2019 Apr 5;2(4):e192561. Epub 2019 Apr 5.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

Importance: There has been significant recent interest in understanding the utility of quantitative imaging to delineate breast cancer intrinsic biological factors and therapeutic response. No clinically accepted biomarkers are as yet available for estimation of response to human epidermal growth factor receptor 2 (currently known as ERBB2, but referred to as HER2 in this study)-targeted therapy in breast cancer.

Objective: To determine whether imaging signatures on clinical breast magnetic resonance imaging (MRI) could noninvasively characterize HER2-positive tumor biological factors and estimate response to HER2-targeted neoadjuvant therapy. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2561DOI Listing

Association of Occupational Pesticide Exposure With Immunochemotherapy Response and Survival Among Patients With Diffuse Large B-Cell Lymphoma.

JAMA Netw Open 2019 Apr 5;2(4):e192093. Epub 2019 Apr 5.

Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology, Nîmes University Hospital, University of Montpellier, Montpellier, France.

Importance: Professional use of pesticides is a risk factor for non-Hodgkin lymphoma. The main biological mechanisms of pesticides and chemotherapy are genotoxicity and reactive oxygen species generation. Cellular adaptation among patients exposed to low doses of genotoxic and oxidative compounds might hinder chemotherapy efficiency in patients with lymphoma. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2093DOI Listing

Southeast Asia Strategic Multilateral Dialogue on Biosecurity.

Emerg Infect Dis 2019 May;25(5)

A strategic multilateral dialogue related to biosecurity risks in Southeast Asia, established in 2014, now includes participants from Singapore, Malaysia, Indonesia, Thailand, Philippines, and the United States. This dialogue is conducted at the nonministerial level, enabling participants to engage without the constraints of operating in their official capacities. Participants reflect on mechanisms to detect, mitigate, and respond to biosecurity risks and highlight biosecurity issues for national leadership. Read More

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http://wwwnc.cdc.gov/eid/article/25/5/18-1659_article.htm
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http://dx.doi.org/10.3201/eid2505.181659DOI Listing
May 2019
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[Progress in vaccine development based on baculovirus expression vector system].

Sheng Wu Gong Cheng Xue Bao 2019 Apr;35(4):577-588

National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian, China.

Baculovirus expression vector system (BEVS) has been successfully applied to the over-expression of various proteins, thus providing sufficient materials for vaccine research. Compared to other systems, BEVS has many advantages: baculovirus solely being parasitic in invertebrates, the resultant products conferring high safety to mammalian, high expression level of recombinant proteins, preferable folding for eukaryotic protein, proper post-translational modification required for biological function, suitable for multiple genes co-expression and large-scale production with serum-free culture media. To better understand the advantages and prospective of BEVS for the vaccine research, this article will review the development of BEVS and its application on vaccine research. Read More

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http://dx.doi.org/10.13345/j.cjb.180301DOI Listing

Genome-wide expression profiling-based copy number variations and colorectal cancer risk in Chinese.

Mol Carcinog 2019 Apr 18. Epub 2019 Apr 18.

Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Genetic factors play important roles in colorectal carcinogenesis. This study was aimed to evaluate the effects of gene expression-related copy number variations (CNVs) on the risk of colorectal cancer in Chinese. Expression Quantitative Trait Locus (eQTL) mapping was conducted to explore the most regulatable gene expressions by CNVs among the whole genome based on publicly available data. Read More

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http://dx.doi.org/10.1002/mc.23015DOI Listing
April 2019
2 Reads

Biochemical diversity of glycosphingolipid biosynthesis as a driver of Coccolithovirus competitive ecology.

Environ Microbiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Marine and Coastal Sciences, Rutgers University, New Brunswick, NJ 08901, USA.

Coccolithoviruses (EhVs) are large, double-stranded DNA-containing viruses that infect the single-celled, marine coccolithophore Emiliania huxleyi. Given the cosmopolitan nature and global importance of E. huxleyi as a bloom-forming, calcifying, photoautotroph, E. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1462-2920.14
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http://dx.doi.org/10.1111/1462-2920.14633DOI Listing
April 2019
2 Reads

The transcription factors ActR and SoxR differentially affect the phenazine tolerance of Agrobacterium tumefaciens.

Mol Microbiol 2019 Apr 19. Epub 2019 Apr 19.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

Bacteria in soils encounter redox-active compounds, such as phenazines, that can generate oxidative stress, but the mechanisms by which different species tolerate these compounds are not fully understood. Here, we identify two transcription factors, ActR and SoxR, that play contrasting yet complementary roles in the tolerance of the soil bacterium Agrobacterium tumefaciens to phenazines. We show that ActR promotes phenazine tolerance by proactively driving expression of a more energy-efficient terminal oxidase at the expense of a less-efficient alternative, which may affect the rate at which phenazines abstract electrons from the electron transport chain and thereby generate reactive oxygen species. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/mmi.14263
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http://dx.doi.org/10.1111/mmi.14263DOI Listing
April 2019
1 Read

Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134.

Appl Microbiol Biotechnol 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Halogen substituents are important for biological activity in many compounds. Genome-based mining of halogenase along with its biosynthetic gene cluster provided an efficient approach for the discovery of naturally occurring organohalogen compounds. Analysis of the genome sequence of a phytopathogenic fungus Bipolaris sorokiniana 11134 revealed a polyketide gene cluster adjacent to a flavin-dependent halogenase capable of encoding halogenated polyketides, which are rarely reported in phytopathogenic fungi. Read More

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http://dx.doi.org/10.1007/s00253-019-09821-zDOI Listing

Comparative RNA-seq analysis of the drought-sensitive lentil (Lens culinaris) root and leaf under short- and long-term water deficits.

Funct Integr Genomics 2019 Apr 18. Epub 2019 Apr 18.

Department of Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, Istanbul, Turkey.

Drought stress is one of the main environmental factors that affects growth and productivity of crop plants, including lentil. To gain insights into the genome-wide transcriptional regulation in lentil root and leaf under short- and long-term drought conditions, we performed RNA-seq on a drought-sensitive lentil cultivar (Lens culinaris Medik. cv. Read More

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http://link.springer.com/10.1007/s10142-019-00675-2
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http://dx.doi.org/10.1007/s10142-019-00675-2DOI Listing
April 2019
1 Read

High temperature and drought stress cause abscisic acid and reactive oxygen species accumulation and suppress seed germination growth in rice.

Protoplasma 2019 Apr 18. Epub 2019 Apr 18.

Collaborative Innovation Center of Henan Grain Crops, Henan Key Laboratory of Rice Biology, Henan Agricultural University, Zhengzhou, China.

Seed germination is one of the most important biological processes in the life cycle of plants, and temperature and water are the two most critical environmental factors that influence seed germination. In the present study, we investigated the roles of the plant hormone abscisic acid (ABA) and reactive oxygen species (ROS) in high temperature (HT) and drought-induced inhibition of rice seed germination. HT and drought stress caused ABA accumulation in seeds and inhibited seed germination and seedling establishment. Read More

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http://link.springer.com/10.1007/s00709-019-01354-6
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http://dx.doi.org/10.1007/s00709-019-01354-6DOI Listing
April 2019
1 Read

[Tight control-Demand for short term control of rheumatoid arthritis].

Z Rheumatol 2019 Apr 18. Epub 2019 Apr 18.

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

The prognosis of rheumatoid arthritis (RA) has been significantly improved in recent decades. This is mainly due to earlier detection, better diagnostics and new treatment options, such as the optimized use of classical disease-modifying antirheumatic drugs (DMARD) and biologicals. Other factors involved were earlier intervention, improved availability of information and analyses and certainly also standardization of care (e. Read More

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http://link.springer.com/10.1007/s00393-019-0631-x
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http://dx.doi.org/10.1007/s00393-019-0631-xDOI Listing
April 2019
1 Read

A systematic review and meta-analysis of environmental, lifestyle and health factors associated with DNA methylation age.

J Gerontol A Biol Sci Med Sci 2019 Apr 17. Epub 2019 Apr 17.

School of Public Health and Preventive Medicine, Monash University, Melbourne, 3004, Victoria, Australia.

DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an individual's chronological age, and can predict of their risk of age-related disease and mortality. This study reviewed the evidence that environmental, lifestyle and health factors are associated with the Horvath and Hannum epigenetic clocks. A systematic search identified 61 studies. Read More

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https://academic.oup.com/biomedgerontology/advance-article/d
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http://dx.doi.org/10.1093/gerona/glz099DOI Listing
April 2019
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Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells.

J Immunol Res 2019 14;2019:9678098. Epub 2019 Mar 14.

Subdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), México City, Mexico.

Valproic acid (VPA) is widely recognized for its use in the control of epilepsy and other neurological disorders in the past 50 years. Recent evidence has shown the potential of VPA in the control of certain cancers, owed in part to its role in modulating epigenetic changes through the inhibition of histone deacetylases, affecting the expression of genes involved in the cell cycle, differentiation, and apoptosis. The direct impact of VPA in cells of the immune system has only been explored recently. Read More

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https://www.hindawi.com/journals/jir/2019/9678098/
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http://dx.doi.org/10.1155/2019/9678098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437734PMC
March 2019
1 Read

The Complex Etiology of Childhood Obesity in Arabs Is Highlighted by a Combination of Biological and Socio-Economic Factors.

Front Public Health 2019 2;7:72. Epub 2019 Apr 2.

Department of Clinical Services, Dasman Diabetes Institute, Kuwait City, Kuwait.

To identify predictors of childhood and adolescent obesity in Kuwaitis with Arab ethnicity. A cross-sectional sample of 6-18 year-old schoolchildren was randomly selected from 244 public schools across all six governorates in the State of Kuwait. Anthropometric data were measured from 6,574 Arab Kuwaiti schoolchildren, and a structured questionnaire was used to collect information on possible risk factors associated with obesity. Read More

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https://www.frontiersin.org/article/10.3389/fpubh.2019.00072
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http://dx.doi.org/10.3389/fpubh.2019.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455072PMC
April 2019
1 Read

Activity of a Synthetic Peptide Targeting MgtC on Intramacrophage Survival and Biofilm Formation.

Front Cell Infect Microbiol 2019 2;9:84. Epub 2019 Apr 2.

Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université Montpellier, Montpellier, France.

Antivirulence strategies aim to target pathogenicity factors while bypassing the pressure on the bacterium to develop resistance. The MgtC membrane protein has been proposed as an attractive target that is involved in the ability of several major bacterial pathogens, including , to survive inside macrophages. In liquid culture, MgtC acts negatively on biofilm formation. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00084
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http://dx.doi.org/10.3389/fcimb.2019.00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454036PMC
April 2019
1 Read

Continuous Use of Combined Hormonal Contraceptive and the Effect on Blood Coagulation Factors in Female Capuchin Monkeys ().

Int J Endocrinol 2019 13;2019:2047803. Epub 2019 Mar 13.

Laboratory of Neuroscience and Behaviour, University of Brasilia, Brasilia, Brazil.

This study aimed at evaluating the availability of the primate as an animal model for research assessing the physiological effects of the continuous use of combined hormonal contraceptives. In order to do this, six reproductively active female from the Primate Research Center of the University of Brasília were selected to take part in this experiment. Every 21 days or so, each female received a single dose of combined hormonal contraceptive (algestone acetophenide and 17-enanthate estradiol) in a total of five doses throughout the experiment. Read More

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http://dx.doi.org/10.1155/2019/2047803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436371PMC

Mutations From Whole Exome Sequencing in Neurodevelopmental and Psychiatric Disorders: From Discovery to Application.

Front Genet 2019 3;10:258. Epub 2019 Apr 3.

Shanghai Mental Health Center, School of Biomedical Engineering, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Neurodevelopmental and psychiatric disorders are a highly disabling and heterogeneous group of developmental and mental disorders, resulting from complex interactions of genetic and environmental risk factors. The nature of multifactorial traits and the presence of comorbidity and polygenicity in these disorders present challenges in both disease risk identification and clinical diagnoses. The genetic component has been firmly established, but the identification of all the causative variants remains elusive. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2019.00258
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http://dx.doi.org/10.3389/fgene.2019.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456656PMC
April 2019
1 Read

Conserved MicroRNA Act Boldly During Sprout Development and Quality Formation in Pingyang Tezaocha ().

Front Genet 2019 28;10:237. Epub 2019 Mar 28.

Qingdao Key Laboratory of Genetic Improvement and Breeding in Horticultural Plants, College of Horticulture, Qingdao Agricultural University, Qingdao, China.

Tea tree [ (L.) O. Kuntze] is an important leaf (sometimes tender stem)-using commercial plant with many medicinal uses. Read More

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http://dx.doi.org/10.3389/fgene.2019.00237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455055PMC

Flax ( L.) Fibers for Composite Reinforcement: Exploring the Link Between Plant Growth, Cell Walls Development, and Fiber Properties.

Front Plant Sci 2019 3;10:411. Epub 2019 Apr 3.

IRDL, UMR CNRS 6027, Université de Bretagne Sud, Lorient, France.

Due to the combination of high mechanical performances and plant-based origin, flax fibers are interesting reinforcement for environmentally friendly composite materials. An increasing amount of research articles and reviews focuses on the processing and properties of flax-based products, without taking into account the original key role of flax fibers, namely, reinforcement elements of the flax stem ( L.). Read More

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http://dx.doi.org/10.3389/fpls.2019.00411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456768PMC
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