3,712,740 results match your criteria Biologicals [Journal]


Unravel a neuroactive sHA sulfation pattern with neurogenesis activity by a library of defined oligosaccharides.

Eur J Med Chem 2018 Dec 4;163:583-596. Epub 2018 Dec 4.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, 100191, Haidian District, Beijing, China. Electronic address:

Sulfated hyaluronic acid (sHA) is chemically synthetic mimetic of glycosaminoglycan (GAG) presenting promising biological functions. Specific sulfation pattern, termed as sulfation code plays critical roles in regulating the binding mode between GAG and proteins. As a structural analogue of chondroitin sulfate (CS), sHA bears much higher molecular weight and is nearly free of other proteoglycan contaminants. Read More

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December 2018

Ecological improvement assessment of a passive remediation technology for acid mine drainage: Water quality biomonitoring using bivalves.

Chemosphere 2018 Dec 6;219:695-703. Epub 2018 Dec 6.

UNESCO UNITWIN/WiCop Department of Physical-Chemistry, University of Cádiz, Campus Río de San Pedro, 11510, Puerto Real, Cádiz, Spain.

A passive treatment plant, located in the Iberian Pyrite Belt (Huelva, Southwest Spain), was designed for acid mine drainage remediation. Since its installation, the improvement of water quality in terms of hydrochemical composition has been demonstrated successfully. However, according to the Water Framework Directive, the treated effluent must have ecological values for potential living. Read More

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December 2018

Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults.

Neuroimage 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224, USA.

White matter microstructure can be measured with diffusion tensor imaging (DTI). While increasing age is a predictor of white matter (WM) microstructure changes, roles of other possible modifiers, such as cardiovascular risk factors, APOE ε4 allele status and biological sex have not been clarified. We investigated 665 cognitively normal participants from the Baltimore Longitudinal Study of Aging (age 50-95, 56. Read More

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December 2018

Exploration of sexual dimorphism and inter-individual variability in multivariate parameter spaces for a pharmacokinetic compartment model.

Math Biosci 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854; Department of Biomedical Engineering, Rutgers The State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854. Electronic address:

Pharmacokinetic models are particularly useful to study the underlying and complex physiological mechanisms contributing to clinical differences across patient subgroups or special populations. Unfortunately, the inherent variability of biological systems and knowledge gaps in physiological data limit confidence in model predictions for special populations. Sourcing data to reflect the desired physiologies can be resource intensive, particularly for a larger model. Read More

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December 2018

Rooting of eucalypt cuttings as a problem-solving oriented model in plant biology.

Prog Biophys Mol Biol 2018 Dec 14. Epub 2018 Dec 14.

Center for Biotechnology and Department of Botany, Federal University of Rio Grande do Sul (UFRGS), P.O. Box 15005, Porto Alegre, RS, 91501-970, Brazil. Electronic address:

Species of Eucalyptus are some of the most planted trees in the world, providing fiber, cellulose, energy, and wood for construction and furniture in renewable fashion, with the added advantage of fixing large amounts of atmospheric carbon. The efficiency of eucalypts in forestry relies mostly on the clonal propagation of selected genotypes both as pure species and interspecific hybrids. The formation of new roots from cambium tissues at the base of cuttings, referred to as adventitious rooting (AR), is essential for accomplishing clonal propagation successfully. Read More

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December 2018
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Systematic in vitro comparison of decellularization protocols for blood vessels.

PLoS One 2018 17;13(12):e0209269. Epub 2018 Dec 17.

Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

Decellularization of native blood vessels is a promising technology to generate 3D biological scaffolds for vascular grafting. Blood vessel decellularization has been performed in previous studies under various experimental conditions, that complicates comparison and optimization of suitable protocols. The goal of this work was to systematically compare the decellularization and recellularization efficacy of 5 different protocols utilizing the detergents sodium dodecyl sulfate (SDS), sodium deoxycholate (SDC), CHAPS and TritonX-100 together with DNA-removing enzymes on porcine vena cava in a perfusion bioreactor setup. Read More

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December 2018
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Public acceptability of development in the Northern Forest of Vermont, USA-The influence of wildlife information, recreation involvement, and demographic characteristics.

PLoS One 2018 17;13(12):e0203515. Epub 2018 Dec 17.

Vermont Department of Fish and Wildlife, Barre, Vermont, United States of America.

Increasing development such as roads and houses will alter future landscapes and result in biological, social, and economic trade-offs. Managing development requires information on the public's acceptability of development and understanding which factors shape acceptability. In this study, we examined three questions: 1) What is the public's acceptability of development? 2) Is acceptability of development influenced by wildlife information? and 3) Is the maximum amount of acceptable development influenced by views about wildlife, involvement in outdoor recreation, and demographic factors? We conducted a visual-preference survey of 9,000 households in Vermont, USA that asked about acceptable levels of development, acceptability of wildlife, involvement in recreation, and individual and town demographics. Read More

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December 2018

regQTLs: Single nucleotide polymorphisms that modulate microRNA regulation of gene expression in tumors.

PLoS Genet 2018 Dec 17;14(12):e1007837. Epub 2018 Dec 17.

Biostatistics Division, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.

Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet their functional properties often remain unclear. It has been hypothesized that SNPs in microRNA binding sites may disrupt gene regulation by microRNAs (miRNAs), short non-coding RNAs that bind to mRNA and downregulate the target gene. While several studies have predicted the location of SNPs in miRNA binding sites, to date there has been no comprehensive analysis of their impact on miRNA regulation. Read More

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December 2018

Fibrosis-4 index at diagnosis can predict all-cause mortality in patients with rheumatoid arthritis: a retrospective monocentric study.

Mod Rheumatol 2018 Dec 17:1-16. Epub 2018 Dec 17.

c Division of Rheumatology, Department of Internal Medicine , Yonsei University College of Medicine , Seoul , Republic of Korea.

Objectives Comorbidities and conventional risk factors influence the prognosis of patients with rheumatoid arthritis (RA). We investigated whether liver fibrosis burden is associated with all-cause mortality in patients with RA. Methods A total of 2812 patients with RA were retrospectively selected and reviewed. Read More

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December 2018

PRENYLATED CURCUMIN ANALOGUES AS MULTIPOTENT TOOLS TO TACKLE ALZHEIMER'S DISEASE.

ACS Chem Neurosci 2018 Dec 17. Epub 2018 Dec 17.

Alzheimer's disease is likely to be caused by copathogenic factors including aggregation of Aβ peptides into oligomers and fibrils, neuroinflammation and oxidative stress. To date, no effective treatments are available and because of the multifactorial nature of the disease, it emerges the need to act on different and simultaneous fronts. Despite the multiple biological activities ascribed to curcumin as neuroprotector, its poor bioavailability and toxicity limit the success in clinical outcomes. Read More

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December 2018

Using OmicsNet for Network Integration and 3D Visualization.

Curr Protoc Bioinformatics 2018 Dec 17:e69. Epub 2018 Dec 17.

Institute of Parasitology, McGill University, Sainte Anne de Bellevue, Quebec, Canada.

OmicsNet is a novel web-based tool for creating and visualizing complex biological networks in 3D space. By coupling a comprehensive knowledgebase with the powerful WebGL technology, OmicsNet allows researchers to intuitively explore molecular interactions and regulatory relationships among genes, transcription factors, microRNAs, and metabolites. OmicsNet fills an important gap by facilitating multi-omics integration and systems biology. Read More

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December 2018
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Morphological variation and covariation in mandibular molars of platyrrhine primates.

J Morphol 2019 Jan;280(1):20-34

Department of Evolutionary Biology, Ecology and Environmental Sciences, University of Barcelona, Barcelona, Spain.

Molars are highly integrated biological structures that have been used for inferring evolutionary relationships among taxa. However, parallel and convergent morphological traits can be affected by developmental and functional constraints. Here, we analyze molar shapes of platyrrhines in order to explore if platyrrhine molar diversity reflects homogeneous patterns of molar variation and covariation. Read More

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January 2019
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Long non-coding RNA LINC00675 inhibits tumorigenesis and EMT via repressing Wnt/β-catenin signaling in esophageal squamous cell carcinoma.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8288-8297

Emergency Department, Shenzhen People's Hospital, the Second Medical College of Jinan University, Shenzhen, Guangdong, China.

Objective: Long noncoding RNA LINC00675 (LINC00675) seems to play an anti-oncogenic role in cancers, though its exact function remains unknown. Up to date, little is known about the role of LINC00675 in esophageal squamous cell carcinoma (ESCC). In this study, we aimed to explore the expression pattern, clinical significance and biological function of LINC00675 in ESCC. Read More

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December 2018

Tropolone natural products.

Nat Prod Rep 2018 Dec 17. Epub 2018 Dec 17.

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Beutenbergstraße 11a, 07745 Jena, Germany.

Covering: 2008 to 2018This review provides a comprehensive overview of newly discovered natural products containing a tropolonoid motif covering 2008 up to 2018 and depicts the ecological context in which they have been isolated. This review has a strong focus on describing the different analytical tools and molecular biological approaches used to identify the underlying biosynthetic pathways. Read More

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December 2018

Sowing confusion in the field: the interchangeable use of biosimilar terminology.

Curr Med Res Opin 2018 Dec 17:1-6. Epub 2018 Dec 17.

a Pfizer Inc.

The Biologics Price Competition and Innovation Act of 2009 (BPCI Act) created an abbreviated licensure pathway in the United States that allows for the development and approval of biologic products shown to be biosimilar to or interchangeable with a US Food and Drug Administration (FDA)-licensed reference product. FDA released the draft guidance for industry on Demonstrating Interchangeability with a Reference Product (hereafter referred to as the Draft Interchangeability Guidance) in January 2017.1 Despite FDA's efforts, there continues to be a great deal of confusion and misinformation surrounding the topic of interchangeability. Read More

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December 2018

Determination of acidic drugs in biological and environmental matrices by membrane-based dual emulsification liquid-phase microextraction followed by high performance liquid chromatography.

J Sep Sci 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemistry, Semnan University, Semnan, Iran.

A simple method is introduced providing a highly clean microextraction for the determination of some anti-inflammatory drugs as the model analytes in human urine and environmental matrices. This method is based upon the implementation of two consecutive emulsification liquid-phase microextractions, which are separated by a syringe filtration step. In this method, the organic extraction solvent (dihexyl ether) is dispersed into the aqueous sample solution (20 mL), and the resulting cloudy mixture is passed through a hydrophilic polytetrafluoroethylene syringe filter. Read More

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December 2018

4"-O-Alkylated α-Galactosylceramide Analogues as iNKT-Cell Antigens: Synthetic, Biological, and Structural Studies.

ChemMedChem 2018 Dec 17. Epub 2018 Dec 17.

Laboratory for Medicinal Chemistry, Department of Pharmaceutics (FFW), Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.

Invariant natural killer T-cells (iNKT) are a glycolipid-responsive subset of T-lymphocytes that fulfill a pivotal role in the immune system. The archetypical synthetic glycolipid, α-galactosylceramide (α-GalCer), whose molecular framework is inspired by a group of amphiphilic natural products, remains the most studied antigen for iNKT-cells. Nonetheless, the potential of α-GalCer as an immunostimulating agent is compromised by the fact that this glycolipid elicits simultaneous secretion of Th1- and Th2-cytokines. Read More

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December 2018

Overview of the blood compatibility of nanomedicines: A trend analysis of in vitro and in vivo studies.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2018 Dec 17:e1546. Epub 2018 Dec 17.

Consumer Products Safety Unit, Directorate F - Health, Consumers and Reference Materials, European Commission Joint Research Centre (JRC), Ispra (VA), Italy.

As nanomedicines have the potential to address many currently unmet medical needs, the early identification of regulatory requirements that could hamper a smooth translation of nanomedicines from the laboratory environment to clinical applications is of utmost importance. The blood system is especially relevant as many nanomedicinal products that are currently under development are designed for intravenous administration and cells of the blood system will be among the first biological systems exposed to the injected nanomedicine. This review collects and summarizes the current knowledge related to the blood compatibility of nanomedicines and nanomaterials with a potential use in biomedical applications. Read More

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December 2018

ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.

Mol Oncol 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Medicine, University of Freiburg, Germany.

A disintegrin and a metalloprotease (ADAM) 9 is a metzincin cell-surface protease with strongly elevated expression in solid tumors, including pancreatic ductal adenocarcinoma (PDAC). In this study, we performed immunohistochemistry (IHC) of a tissue microarray (TMA) to examine the expression of ADAM9 in a cohort of > 100 clinically-annotated PDAC cases. We report that ADAM9 is prominently expressed by PDAC tumor cells, and increased ADAM9 expression levels correlate with poor tumor grading (p = 0. Read More

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December 2018

Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity.

Nat Prod Rep 2018 Dec 17. Epub 2018 Dec 17.

Retired Chief, Natural Products Branch, NCI/NIH, NIH Special Volunteer, Wayne, Pennsylvania 19087, USA.

Covering: 1957 to 2017Algae constitute a heterogeneous group of eukaryotic photosynthetic organisms, mainly found in the marine environment. Algae produce numerous metabolites that help them cope with the harsh conditions of the marine environment. Because of their structural diversity and uniqueness, these molecules have recently gained a lot of interest for the identification of medicinally useful agents, including those with potential anticancer activities. Read More

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December 2018

Multi-Target Drugs Against Metabolic Disorders.

Endocr Metab Immune Disord Drug Targets 2018 Dec 17. Epub 2018 Dec 17.

Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa - PB. Brazil.

In silico studies are increasingly being applied by researchers due to reductions in time and costs for new prototype synthesis; obtaining substances that present better therapeutic profiles. In the present work, in addition to discussing multi-target drug discovery and the contributions of in silico studies to rational bioactive planning against metabolic disorders such as diabetes and obesity, we review various in silico study contributions to the fight against human metabolic pathologies. Read More

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December 2018

Cardiovascular risk profiling of long-lived people shows peculiar associations with mortality compared with younger individuals.

Geriatr Gerontol Int 2018 Dec 16. Epub 2018 Dec 16.

Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.

Aim: Centenarians represent a biological model of successful aging because they escaped/postponed most invalidating age-related diseases, such as cardiovascular diseases. The aim of the present study was to clarify whether a favorable cardiovascular risk profile increases the survival chances in long-lived people.

Methods: A total of 355 community-dwelling nonagenarians and centenarians living in Southern Italy were recruited in the study. Read More

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December 2018

Characterization of LRL5 as a key regulator of root hair growth in maize.

Plant J 2018 Dec 17. Epub 2018 Dec 17.

State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.

Root hair, the special type of tubular-shaped cell, outgrows from root epidermal cell and plays important roles in the acquisition of nutrient and water, as well as the interactions with biotic and abiotic stresses. Studies in the model plant Arabidopsis have revealed that the root-hair initiation and elongation are hierarchically regulated by a group of basic helix-loop-helix (bHLH) transcription factors (TFs). However, knowledge regarding the regulatory pathways of these bHLH-TFs in controlling root hair growth remains limited. Read More

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December 2018
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Elongation of Müllerian ducts and connection to urogenital sinus determine the borderline of uterine and vaginal development.

Biochem Biophys Rep 2019 Mar 30;17:44-50. Epub 2018 Nov 30.

Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan.

In female mice, proximal, middle and caudal Müllerian ducts (MDs) differentiate into oviduct, uterus and vagina, respectively. The fates of female reproductive tract epithelia are determined by the mesenchyme. However, the mesenchymal fate determination system is still unclear. Read More

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Effects of Nonionic Surfactants on Xanthan Gum Production: a Survey on Cellular Interactions.

Iran J Biotechnol 2018 Apr 18;16(1):e1483. Epub 2018 Apr 18.

Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Tehran, Iran.

Background: is a biopolymer producing gram negative bacterium. Production of xanthan biopolymer can be affected by different extrinsic factors as well as surfactants. Hitherto, effects of nonionic surfactants on xanthan production have been studied in a limited number of articles. Read More

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Infant Feeding Practices in China and Ireland: Ireland Chinese Mother Survey.

Front Public Health 2018 28;6:351. Epub 2018 Nov 28.

School of Biological Sciences, Dublin Institute of Technology, Dublin, Ireland.

Migration to another country may induce changes in infant feeding practices especially where such practices differ considerably between the two countries. This study was undertaken to compare the infant feeding practices between Chinese mothers who gave birth in Ireland (CMI) with immigrant Chinese mothers who gave birth in China (CMC), and to examine the factors that influence these practices. A cross-sectional self-administrated survey was conducted among a convenience sample of 322 Chinese mothers living in Ireland. Read More

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November 2018

Immune cell counts and signaling in body fluids of cows vaccinated against .

J Biol Res (Thessalon) 2018 Dec 10;25:20. Epub 2018 Dec 10.

Chair of Animal Physiology and Immunology, Technical University of Munich (TUM), Weihenstephaner Berg 3, 85354 Freising, Germany.

Background: New treatment options are needed to prevent relapses following failed antibiotic therapies of infections (CDI) in humans. The concomitant therapy with an anti- IgA containing whey protein concentrate can support the sustainable recovery of CDI patients. For 31 weeks, nine dairy cows were continuously vaccinated with several anti- vaccines by certain routes of administration to produce anti- IgA enriched milk. Read More

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December 2018

Polysialic acid is released by human umbilical vein endothelial cells (HUVEC) in vitro.

Cell Biosci 2018 11;8:64. Epub 2018 Dec 11.

1Institute of Biochemistry, Faculty of Medicine, Justus-Liebig-University, Friedrichstrasse 24, 35392 Giessen, Germany.

Background: Sialic acids represent common terminal residues on numerous mammalian glycoconjugates, thereby influencing e.g. lumen formation in developing blood vessels. Read More

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December 2018

Conversion of Sugars and Biomass to Furans Using Heterogeneous Catalysts in Biphasic Solvent Systems.

ChemCatChem 2018 Nov 13;10(21):4805-4816. Epub 2018 Sep 13.

Department of Chemical and Biological Engineering Montana State University Bozeman 59717-2220 MT USA.

Within the last decade, interest in using biphasic systems for producing furans from biomass has grown significantly. Biphasic systems continuously extract furans into the organic phase, which prevents degradation reactions and potentially allows for easier separations of the products. Several heterogeneous catalyst types, including zeolites, ion exchange resins, niobium-based, and others, have been used with various organic solvents to increase furan yields from sugar dehydration reactions. Read More

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November 2018

Injection of Adipose-Derived Stromal Cells in the Knee of Patients with Severe Osteoarthritis has a Systemic Effect and Promotes an Anti-Inflammatory Phenotype of Circulating Immune Cells.

Theranostics 2018 5;8(20):5519-5528. Epub 2018 Nov 5.

IRMB, INSERM, Université Montpellier, Montpellier, France.

Recent studies confirmed that osteoarthritis (OA) is associated with systemic inflammation. Adipose-derived stromal cells (ASCs) could become the most promising cell-based therapy in OA, based not only on their differentiation capacities and trophic and paracrine effects on the existing cartilage, but also on their immunomodulatory properties. Here, we wanted to determine the biological effect of autologous ASC intra-articular (IA) injection. Read More

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November 2018

Molecular Control by Non-coding RNAs During Fruit Development: From Gynoecium Patterning to Fruit Ripening.

Front Plant Sci 2018 30;9:1760. Epub 2018 Nov 30.

Laboratory of Molecular Genetics of Plant Development, Department of Biological Sciences (LCB), Escola Superior de Agricultura "Luiz de Queiroz" (ESALQ), University of São Paulo, São Paulo, Brazil.

Fruits are originated from the transition of a quiescent ovary to a fast-growing young fruit. The evolution of reproductive structures such as ovary and fruit has made seed dispersal easier, which is a key process for reproductive success in flowering plants. The complete fruit development and ripening are characterized by a remarkable phenotypic plasticity which is orchestrated by a myriad of genetic factors. Read More

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November 2018

Extracellular Vesicle-Mediated Immune Regulation of Tissue Remodeling and Angiogenesis After Myocardial Infarction.

Front Immunol 2018 29;9:2799. Epub 2018 Nov 29.

Immunology Service, Hospital de la Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, Madrid, Spain.

Myocardial ischemia-related disorders constitute a major health problem, being a leading cause of death in the world. Upon ischemia, tissue remodeling processes come into play, comprising a series of inter-dependent stages, including inflammation, cell proliferation and repair. Neovessel formation during late phases of remodeling provides oxygen supply, together with cellular and soluble components necessary for an efficient myocardial reconstruction. Read More

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November 2018
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Uncovering Biologically Coherent Peripheral Signatures of Health and Risk for Alzheimer's Disease in the Aging Brain.

Front Aging Neurosci 2018 29;10:390. Epub 2018 Nov 29.

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, CA, United States.

Brain aging is a multifaceted process that remains poorly understood. Despite significant advances in technology, progress toward identifying reliable risk factors for suboptimal brain health requires realistically complex analytic methods to explain relationships between genetics, biology, and environment. Here we show the utility of a novel unsupervised machine learning technique - Correlation Explanation (CorEx) - to discover how individual measures from structural brain imaging, genetics, plasma, and CSF markers can jointly provide information on risk for Alzheimer's disease (AD). Read More

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November 2018

The jasmonate-responsive transcription factor regulates terpenoid biosynthetic genes to promote saponin biosynthesis in H. Lév.

J Genet 2018 Dec;97(5):1379-1388

College of life Science, Sichuan Agricultural University, No. 46, XinKang Road, Ya'an 625014, Sichuan, People's Republic of China.

H. Lév., the most effective component is saponin, is a biennial medicinal material that needs to be overwintered. Read More

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December 2018

Hybrid corn and the unsettled question of heterosis.

J Genet 2018 Dec;97(5):1075-1082

Directeur de Recherche (retired), INRA, 2 place Pierre Viala, 34000 Montpellier, France.

George Shull's 1908 seminal article 'The composition of a field of maize' marked the 'exploitation of heterosis in plant breeding, surely one of genetics' greatest triumphs'. Hybrid corn became a 'symbol of American agriculture' and 'the paradigm for all developments of F hybrid crop varieties and more generally breeding. But there is still no consensus on the definition of heterosis while its biological basis, causal factors and genetic mechanisms remain 'unknown', or at best 'poorly understood'. Read More

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December 2018

Decision Making About Pathways Through Care for Racially and Ethnically Diverse Young Adults With Early Psychosis.

Psychiatr Serv 2018 Dec 17:appips201700459. Epub 2018 Dec 17.

Department of Anthropology, Southern Methodist University, Dallas (Myers, Fox); Department of Psychiatry, University of Texas Southwestern Medical School, Dallas (Myers, Sood); Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York (Compton). Ms. Myers was with the Department of Biological Sciences and the Department of Anthropology, Southern Methodist University, Dallas, at the time of this study.

Objective:: This study elicited factors that shaped treatment decision making for young adults and their key supporters after an initial hospitalization for psychosis to generate hypotheses about how to improve service engagement.

Methods:: This prospective, longitudinal, ethnographic study (using home visits, interviews, and hospital-based fieldwork) asked what mattered to 18 young adults primarily from racial-ethnic minority groups and 19 of their self-identified key supporters (N=37) as they made decisions about treatment during the 12-week critical period after an initial hospitalization for psychosis. The analytical approach used inductive coding and constructivist grounded theory methods to analyze interview transcripts and field notes from home visits and generate hypotheses about key factors that seemed to affect treatment decision making. Read More

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December 2018

Soil organic carbon stability in forests: distinct effects of tree species identity and traits.

Glob Chang Biol 2018 Dec 16. Epub 2018 Dec 16.

Chair of Soil Science, Technical University Munich (TUM), Emil-Ramann-Str. 2, D-85354, Freising, Germany.

Rising atmospheric CO concentrations have increased interest in the potential for forest ecosystems and soils to act as carbon (C) sinks. While soil organic C contents often vary with tree species identity, little is known about if, and how, tree species influence the stability of C in soil. Using a 40-year-old common garden experiment with replicated plots of eleven temperate tree species, we investigated relationships between soil organic matter (SOM) stability in mineral soils and 17 ecological factors (including tree tissue chemistry, magnitude of organic matter inputs and their turnover, microbial community descriptors, and soil physico-chemical properties). Read More

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December 2018

Comparative analysis of intracellular metabolites, proteins and their molecular functions in a flor yeast strain under two enological conditions.

World J Microbiol Biotechnol 2018 Dec 15;35(1). Epub 2018 Dec 15.

Department of Microbiology, Severo Ochoa (C6) building, Agrifood Campus of International Excellence ceiA3, University of Córdoba, Córdoba, Spain.

Flor yeasts confer a wide range of organoleptic properties to Sherry-type wines during a process called "biological aging" that takes place after alcoholic fermentation. These kinds of yeasts adapt to a biological aging condition by forming a biofilm known as "flor velum" and by changing from fermentative to oxidative metabolism. It has been reported that some functions such as increase of cell surface hydrophobicity or changes to lipid metabolism are enhanced when yeasts switch to biofilm lifestyle. Read More

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December 2018

Incorporating non-biological factors into the TNM staging system for better prognostication and decision-making in testicular cancer.

World J Urol 2018 Dec 15. Epub 2018 Dec 15.

Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Background: We combined county-level socioeconomic status (SES), marital status and insurance status to introduce NBF-stage, which were further incorporated into the American Joint Committee on Cancer (AJCC) TNM staging system to generate an integrated staging system for better prognostication and decision-making for testicular cancer patients.

Methods: 15,324 eligible patients diagnosed with primary testicular cancer between January 1, 2007 and December 31, 2015 were strictly selected from the Surveillance, Epidemiology, and End Results (SEER) database. Independent survival predictors were determined based on Cox proportional hazards model. Read More

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December 2018
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Liquid Biopsy for the Management of Patients with Colorectal Cancer.

Digestion 2018 Dec 14;99(1):39-45. Epub 2018 Dec 14.

Background: Liquid biopsy is a collective term that refers to the analysis of tumor-derived biomarkers isolated from biological fluids of cancer patients. Recently, many authors reported the usefulness of liquid biopsy for the management of malignancy. Summary and Key Messages: The peripheral blood of cancer patients is a pool of cells and/or cell products derived from the primary or metastatic tumor, including circulating tumor cells (CTCs), circulating free (cf) DNA or RNA, and exosomes containing proteins, nucleic acids, and lipids. Read More

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December 2018

Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice.

Gut 2018 Dec 15. Epub 2018 Dec 15.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Objective: Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we propose that toll-like receptor 4 (TLR4)-mediated intestinal dysfunction could contribute to intestinal and central inflammation in PD-related neurodegeneration.

Design: To test this hypothesis we performed studies in both human tissue and a murine model of PD. Read More

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December 2018

Physical activity less than the recommended amount may prevent the onset of major biological risk factors for cardiovascular disease: a cohort study of 198 919 adults.

Br J Sports Med 2018 Dec 15. Epub 2018 Dec 15.

IMDEA Food Institute, CEI UAM+CSIC, Madrid, Spain.

Objectives: We examined the dose-response relationship between physical activity (PA) and incidence of cardiovascular disease (CVD) risk factors in adults in Taiwan.

Methods: This study included 1 98 919 participants, aged 18-97 years, free of CVD, cancer and diabetes at baseline (1997-2013), who were followed until 2016. At baseline, participants were classified into five PA levels: inactive' (0 metabolic equivalent of task (MET)-h/week), 'lower insufficiently active' (0. Read More

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December 2018

Risk factors for childhood violence and polyvictimization: A cross-country analysis from three regions.

Child Abuse Negl 2018 Dec 13;88:348-361. Epub 2018 Dec 13.

UNICEF Office of Research-Innocenti, Piazza SS Annunziata 12, 50121, Florence, Italy.

Understanding risk factors is important to ending childhood violence and meeting Sustainable Development Goal 16.2. To date, no study has examined patterns of risk factors across countries comprehensively for different types of childhood violence, and there is a dearth of evidence of polyvictimization in lower- and middle-income settings. Read More

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December 2018
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Heparan Sulfate Proteoglycan Synthesis is Dysregulated in Human Osteoarthritic Cartilage.

Am J Pathol 2018 Dec 13. Epub 2018 Dec 13.

Arthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford, OX3 7FY, UK. Electronic address:

Osteoarthritis (OA) is a common degenerative joint disease, characterized by cartilage loss and subchondral bone remodelling in response to abnormal mechanical load. Heparan sulfate (HS) proteoglycans bind to many proteins that regulate cartilage homeostasis, including growth factors, morphogens, proteases, and their inhibitors, and modulate their localization, retention, and biological activity. Changes in HS expression and structure may thus have important consequences for joint health. Read More

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December 2018

Interpersonal-Level Discrimination Indices, Sociodemographic Factors, and Telomere Length in African-Americans and Whites.

Biol Psychol 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD, USA.

Objective: Studies have linked self-reported discrimination to telomere attrition, a biological marker of accelerated cellular aging. However, it is unknown whether intersections between social categories-race, socioeconomic status (SES), sex, and age-influence the association of varying forms of discrimination with telomere length. We examined these associations in a socioeconomically and racially/ethnically diverse urban sample. Read More

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December 2018

Δ-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPARα induction: A possible evidence for the cancellation of PPARβ/δ-mediated inhibition of PPARα in MDA-MB-231 cells.

Arch Biochem Biophys 2018 Dec 13. Epub 2018 Dec 13.

Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka, 815-8511, Japan.

Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear transcription factors, with three characterized subtypes: PPARα, PPARβ/δ, and PPARγ. The biological correlation between the two PPAR subtypes PPARα and γ and carcinogenesis is well-characterized; however, substantially less is known about the biological functions of PPARβ/δ. PPARβ/δ has been reported to repress transcription when PPARβ/δ and PPARα or PPARγ are simultaneously expressed in some cells, and MDA-MB-231 cells express functional levels of PPARβ/δ. Read More

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December 2018

Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.

Bioorg Med Chem Lett 2018 Dec 10. Epub 2018 Dec 10.

Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, MD 21702, United States; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States. Electronic address:

Two new cassaine-type diterpenoids, namely erythrofordins D (1) and E (2), sourced from a Cameroon collection of Erythrophleum suaveolens were isolated and assessed for anti-tumor activity. In the NCI-60 cancer cell assay, erythrofordins D (1) and E (2) were found to be cytotoxic in the low micro molar ranges with a mean GI value of 2.45 and 0. Read More

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December 2018

Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems.

Chem Biol Interact 2018 Dec 13. Epub 2018 Dec 13.

Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia; Faculty of Science, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia.

Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. Read More

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December 2018

Interlaboratory comparison about feasibility of insoluble particulate matter test for injections with reduced test volume in light obscuration method.

Biologicals 2018 Dec 12. Epub 2018 Dec 12.

Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tonomachi 3-25-26, Kawasaki-ku, Kanagawa, 210-9501, Japan.

Insoluble particulate matter test for injections in pharmacopoeia is mandatory for parenteral drug products. In this test using light obscuration, four measurements of at least 5-mL are required. Since therapeutic protein injections of low dosage volumes are getting more popular, reduction of test volumes is desired. Read More

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December 2018

Comparison of different PCR protocols and respective primer sets from pool of TAMS 1 gene for diagnosis of calf theileriosis from semi arid India.

Biologicals 2018 Dec 12. Epub 2018 Dec 12.

U P Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, 281001, India.

The polymorphic nature of Theileria annulata merozoite surface antigen (TAMS 1) attributes to limitation in PCR based detection of various T. annulata genotypes present in different geographical domains across the globe. Multiple reports of failure of detection of tropical theileriosis using classical N516/517 primer set in the studied area were noticed. Read More

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December 2018
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