79,521 results match your criteria Biologically Inspired Cognitive Architectures[Journal]


Highly Enantioselective Cross-Electrophile Aryl-Alkenylation of Unactivated Alkenes.

J Am Chem Soc 2019 Apr 19. Epub 2019 Apr 19.

Enantioselective cross-electrophile reactions remain challenging subject in metal catalysis, and, to data, studies have mainly focused on stereoconvergent reactions of racemic alkyl electrophiles. Here, we report an enantioselective cross-electrophile aryl-alkenylation reaction of unactivated alkenes. This method provides access to a number of biologically important chiral molecules such as dihydrobenzofurans, indolines and indanes. Read More

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http://dx.doi.org/10.1021/jacs.9b03863DOI Listing
April 2019
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On Water Cp*Ir(III)-Catalyzed C-H Functionalization for the Synthesis of Chromones through Annulation of Salicylaldehydes with Diazo-Ketones.

J Org Chem 2019 Apr 19. Epub 2019 Apr 19.

A high-valent Ir(III)-catalyzed C-H bond functionalization is carried out for the first time on water for the synthesis of biologically relevant chromone moiety. The C-H activation and annulation of salicylaldehydes with diazo-compounds provided the desired chromones. The synthesis of C3-substitution free chromones has also been demonstrated by a one-pot decarboxylation by employing tert. Read More

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http://dx.doi.org/10.1021/acs.joc.9b00418DOI Listing

Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus.

J Nat Prod 2019 Apr 19. Epub 2019 Apr 19.

Department of Microbial Drugs , Helmholtz Centre for Infection Research (HZI), and German Centre for Infection Research (DZIF) , Partner Site Hannover/Braunschweig, Inhoffenstrasse 7 , 38124 Braunschweig , Germany.

During the course of searching for new anti-infective and other biologically active secondary metabolites from Kenyan basidiomycetes, 13 previously undescribed metabolites, (6 R,7 S,10 R)-7,10-epoxy-7,11-dimethyldodec-1-ene-6,11-diol (1) and 12 sesquiterpenes named elgonenes A-L (2-13), and the known compound P-coumaric acid (14) were isolated from a basidiomycete collected in Mount Elgon Natural Reserve. The producing organism represents a new species of the genus Sanghuangporus, which is one of the segregates of the important traditional Asian medicinal mushrooms that were formerly known as the " Inonotus linteus" complex. The structure elucidation of compounds 1-13, based on 2D NMR spectroscopy, high-resolution mass spectrometry, and other spectral methods, and their antibacterial, antifungal, and cytotoxic activities are reported. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b01086DOI Listing

Inconvenient Truths About Human Longevity.

J Gerontol A Biol Sci Med Sci 2019 Apr 17. Epub 2019 Apr 17.

University of Oklahoma.

The rise in human longevity is one of humanity's crowning achievements. While advances in public health beginning in the 19th century initiated the rise in life expectancy, recent gains have been achieved by reducing death rates at middle and older ages. A debate about the future course of life expectancy has been ongoing for the last quarter century. Read More

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http://dx.doi.org/10.1093/gerona/glz098DOI Listing
April 2019
2 Reads

Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate.

Front Chem 2019 27;7:172. Epub 2019 Mar 27.

Department of Biology, Chemistry, and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.

Interest in biologically active materials that can be used as cell culture substrates for medicinal applications has increased dramatically over the last decade. The design and development of biomaterials mimicking the natural environment of different cell types, the so-called extracellular matrix (ECM), is the focus of research in this field. The ECM exists as an ensemble of several adhesion proteins with different functionalities that can be presented to the embedded cells. Read More

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http://dx.doi.org/10.3389/fchem.2019.00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455064PMC
March 2019
1 Read

Biologically Inspired and Rehabilitation Robotics.

Appl Bionics Biomech 2019 13;2019:2428707. Epub 2019 Mar 13.

Khalifa University Center for Autonomous Robotics Systems and Department of Mechanical Engineering, Khalifa University of Science and Technology, PO Box, 127788 Abu Dhabi, UAE.

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http://dx.doi.org/10.1155/2019/2428707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436330PMC

Preliminary Research: Description of Lip Print Patterns in Children and Their Parents among Deutero-Malay Population in Indonesia.

Int J Dent 2019 13;2019:7629146. Epub 2019 Mar 13.

Lecturer and Researcher in Oral Medicine Department-Forensic Odontology, Fakultas Kedokteran Gigi, Universitas Padjadjaran, Bandung, West Java, Indonesia.

Introduction: Human identification is vital not only in legal medicine but also in criminal inquiries and identification. Cheiloscopy is the study of lip prints which are unique, individual, and heritable that is used for personal identification purposes in forensic odontology.

Objective: The aim of this study is to identify the possibility of the child to inherit the lip print patterns from their parents and also to describe the lip print patterns in children and their parents among the Deutero-Malay population. Read More

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http://dx.doi.org/10.1155/2019/7629146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436370PMC

Transporter-Mediated Subcellular Distribution in the Metabolism and Signaling of Jasmonates.

Front Plant Sci 2019 2;10:390. Epub 2019 Apr 2.

Department of Ecology, College of Resources and Environmental Sciences, China Agricultural University, Beijing, China.

Jasmonates (jasmonic acid and its relatives) are a group of oxylipin phytohormones that are implicated in the regulation of a range of developmental processes and responses to environmental stimuli in plants. The biosynthesis of JAs occur sequentially in various subcellular compartments including the chloroplasts, peroxisomes and the cytoplasm. The biologically active jasmonoyl-isoleucine (JA-Ile) activates the core JA signaling in the nucleus by binding with its coreceptor, SCF-JAZ. Read More

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http://dx.doi.org/10.3389/fpls.2019.00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454866PMC

The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach.

Sci Rep 2019 Apr 18;9(1):983. Epub 2019 Apr 18.

Department of Clinical & Biological Psychology, Institute of Psychology and Education, Ulm University, Albert-Einstein-Allee 47, Ulm, 89081, Germany.

While biological alterations associated with childhood maltreatment (CM) have been found in affected individuals, it remains unknown to what degree these alterations are biologically transmitted to the next generation. We investigated intergenerational effects of maternal CM on DNA methylation and gene expression in N = 113 mother-infant dyads shortly after parturition, additionally accounting for the role of the FKBP5 rs1360780 genotype. Using mass array spectrometry, we assessed the DNA methylation of selected stress-response-associated genes (FK506 binding protein 51 [FKBP5], glucocorticoid receptor [NR3C1], corticotropin-releasing hormone receptor 1 [CRHR1]) in isolated immune cells from maternal blood and neonatal umbilical cord blood. Read More

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http://dx.doi.org/10.1038/s41598-018-36689-2DOI Listing

Clinical, immunophenotypic, and genomic findings of acute undifferentiated leukemia and comparison to acute myeloid leukemia with minimal differentiation: a study from the bone marrow pathology group.

Mod Pathol 2019 Apr 18. Epub 2019 Apr 18.

Department of Pathology and Laboratory Medicine, University of Chicago, Chicago, IL, USA.

Acute undifferentiated leukemia is a rare type of acute leukemia that shows no evidence of differentiation along any lineage. Clinical, immunophenotypic and genetic data is limited and it is uncertain if acute undifferentiated leukemia is biologically distinct from acute myeloid leukemia with minimal differentiation, which also shows limited myeloid marker expression and has been reported to have a poor prognosis. We identified 92 cases initially diagnosed as acute undifferentiated leukemia or acute myeloid leukemia with minimal differentiation from pathology databases of nine academic institutions with available diagnostic flow cytometric data, cytogenetic findings, mutational and clinical data. Read More

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http://dx.doi.org/10.1038/s41379-019-0263-3DOI Listing

Is Atrial Natriuretic Peptide (ANP) and Natriuretic Peptide Receptor-A (NPR-A) Expression in Human Placenta and Decidua Normal?

Med Sci Monit 2019 Apr 19;25:2868-2878. Epub 2019 Apr 19.

Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood pressure and the salt-water balance in the blood. It acts through natriuretic peptide receptors (NPR), and the major biologically active ANP receptor is natriuretic peptide receptor-A (NPR-A). Aberrant forms of ANP and its receptors have been reported in patients with preeclampsia. Read More

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http://dx.doi.org/10.12659/MSM.915449DOI Listing

Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies.

Science 2019 Apr 18. Epub 2019 Apr 18.

Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA 02215, USA.

Eukaryotic genes are regulated by multivalent transcription factor complexes. Through cooperative self-assembly, these complexes perform non-linear regulatory operations involved in cellular decision-making and signal processing. Here, we apply this design principle to synthetic networks, testing whether engineered cooperative assemblies can program non-linear gene circuit behavior in yeast. Read More

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http://dx.doi.org/10.1126/science.aau8287DOI Listing

Early-onset emphysema in a large French-Canadian family: a genetic investigation.

Lancet Respir Med 2019 Apr 15. Epub 2019 Apr 15.

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec, Canada.

Background: Inherited mutations in SERPINA1 coding for the alpha-1 antitrypsin (A1AT) protein is the only well established cause of hereditary emphysema. We aimed to identify the genetic ecause of early-onset emphysema in a five-generation French-Canadian family free of A1AT deficiency.

Methods: Between Dec 1, 2014, and April 1, 2017, we investigated 63 individuals from a single pedigree, including 55 with DNA available. Read More

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http://dx.doi.org/10.1016/S2213-2600(19)30056-6DOI Listing

Mineral Metabolism Disturbances and Arteriovenous Fistula Maturation.

Eur J Vasc Endovasc Surg 2019 Apr 15. Epub 2019 Apr 15.

Kidney Research Institute, University of Washington, Seattle, WA, USA.

Background: The arteriovenous fistula (AVF) is central to haemodialysis treatment, but up to half of surgically created AVF fail to mature. Chronic kidney disease often leads to mineral metabolism disturbances that may interfere with AVF maturation through adverse vascular effects. This study tested associations between mineral metabolism markers and vein histology at AVF creation and unassisted and overall clinical AVF maturation. Read More

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http://dx.doi.org/10.1016/j.ejvs.2019.01.022DOI Listing

Structure-activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis.

Bioorg Med Chem Lett 2019 Apr 12. Epub 2019 Apr 12.

Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP 09210-580, Brazil. Electronic address:

Chagas disease represents one of several neglected diseases with a reduced number of chemotherapeutical drugs including the highly toxic compounds benznidazole and nifurtimox. In this sense, natural products represent an import scaffold for the discovery of new biologically active compounds, in which chalcones are promising representatives due to their antitrypanosomal potential. In this work, a series of 36 chalcone derivatives were synthesized and tested against trypomastigotes of Trypanosoma cruzi. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X193024
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http://dx.doi.org/10.1016/j.bmcl.2019.04.020DOI Listing
April 2019
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Ventricular Arrhythmias in Ischemic Cardiomyopathy: Is Imaging-Based Entropy a Biologically Relevant Risk Marker?

JACC Clin Electrophysiol 2019 Apr;5(4):490-492

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.jacep.2018.11.017DOI Listing

Sero-epidemiological status and risk factors of toxoplasmosis in pregnant women in Northern Vietnam.

BMC Infect Dis 2019 Apr 18;19(1):329. Epub 2019 Apr 18.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

Background: In Vietnam, few studies have determined the epidemiological status of toxoplasmosis in pregnant women and no routine prenatal screening is in place. This study was conducted to evaluate the seroprevalence of this zoonotic parasitic infection in pregnant women in Northern Vietnam and to assess the association with awareness, risk factors and congenital toxoplasmosis.

Methods: Approximately 800 pregnant women were included in the study from two hospitals, one in Hanoi and one in Thai Binh province, which is known to have a dense cat population. Read More

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http://dx.doi.org/10.1186/s12879-019-3885-7DOI Listing

Lonely SARTs: loneliness and sustained attention in the Irish longitudinal study of aging.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 Apr 18:1-10. Epub 2019 Apr 18.

c School of Nursing, School of Medicine, and School of Medical Gerontology , Trinity College , Dublin 2 , Ireland.

Based on biologically plausible mechanisms and previous research, it is possible to hypothesize a reciprocal association between sustained attention and loneliness. We investigated this association using a cross-lagged modeling approach. Using data from 6,239 participants aged over 50 in TILDA, a nationally representative study of aging, we used structural equation models to investigate potential cross-lagged associations between sustained attention and loneliness, measured at baseline and again after four years. Read More

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https://www.tandfonline.com/doi/full/10.1080/13825585.2019.1
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http://dx.doi.org/10.1080/13825585.2019.1602705DOI Listing
April 2019
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The Influence of Diet on MicroRNAs that Impact Cardiovascular Disease.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Institute of Cardiovascular Sciences and the Canadian Centre for Agri-food Research in Health and Medicine (CCARM), Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB R2H2A6, Canada.

Food quality and nutritional habits strongly influence human health status. Extensive research has been conducted to confirm that foods rich in biologically active nutrients have a positive impact on the onset and development of different pathological processes, including cardiovascular diseases. However, the underlying mechanisms by which dietary compounds regulate cardiovascular function have not yet been fully clarified. Read More

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https://www.mdpi.com/1420-3049/24/8/1509
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http://dx.doi.org/10.3390/molecules24081509DOI Listing
April 2019
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Computational identification of RNA-Seq based miRNA-mediated prognostic modules in cancer.

IEEE J Biomed Health Inform 2019 Apr 16. Epub 2019 Apr 16.

Systematic identification of miRNA prognostic signature can help decipher the effects of biomarkers in cancer treatment. A number of previous studies have only characterized a single miRNA as a promising prognostic biomarker. There is currently a trend towards combining several miRNAs as a panel of prognostic signatures, but few attempt to explain the mechanism of miRNA combination. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2911528DOI Listing

Responsive Porous Microcarriers With Controllable Oxygen Delivery for Wound Healing.

Small 2019 Apr 17:e1901254. Epub 2019 Apr 17.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.

Microcarriers with oxygen-delivering capacity have attracted increasing interest in the field of tissue regeneration. Here, a kind of molybdenum disulfide quantum dots (MoS QDs) integrated responsive porous microcarriers with controllable oxygen-delivering ability for wound healing is presented. The specific gelatin methacryloyl (GelMa) porous microcarriers are derived from inverse opal microparticles which can be decorated with the oxygen-carrying protein hemoglobin. Read More

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http://dx.doi.org/10.1002/smll.201901254DOI Listing

Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells.

Inflammation 2019 Apr 17. Epub 2019 Apr 17.

Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8504, Japan.

Sudachitin, a polymethoxylated flavonoid found in the skin of Citrus sudachi, is a biologically active substance. The aim of this study was to examine whether sudachitin could be used to inhibit the expression of matrix metalloproteinase (MMP)-1 and MMP-3, which are involved in the destruction of periodontal tissues in periodontal lesions, in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Sudachitin suppressed TNF-α-induced MMP-1 and MMP-3 production in HPDLC. Read More

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http://dx.doi.org/10.1007/s10753-019-01007-zDOI Listing

Droplet-based single cell RNAseq tools: a practical guide.

Lab Chip 2019 Apr 18. Epub 2019 Apr 18.

St Vincent's School of Medicine, Faculty of Medicine, University of New South Wales Sydney, Sydney, NSW, Australia and Tumour Development, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia.

Droplet based scRNA-seq systems such as Drop-seq, inDrop and Chromium 10X have been the catalyst for the wide adoption of high-throughput scRNA-seq technologies in the research laboratory. In order to understand the capabilities of these systems to deeply interrogate biology; here we provide a practical guide through all the steps involved in a typical scRNA-seq experiment. Through comparing and contrasting these three main droplet based systems (and their derivatives), we provide an overview of all critical considerations in obtaining high quality and biologically relevant data. Read More

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http://xlink.rsc.org/?DOI=C8LC01239C
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http://dx.doi.org/10.1039/c8lc01239cDOI Listing
April 2019
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Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes.

Chem Commun (Camb) 2019 Apr 18. Epub 2019 Apr 18.

Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan. and Frontier Research Institute for Material Science, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.

The enantioselective conjugate addition reaction of an α,α-dithioacetonitrile with nitroalkenes was catalysed by chiral bis(imidazoline)-palladium pincer-type complexes. The reaction was applicable to various nitroalkenes to afford products in good yield with high enantioselectivity. The obtained products can be converted to γ-lactam and biologically active rolipram. Read More

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http://dx.doi.org/10.1039/c9cc02443cDOI Listing

Selective C-C bond formation from rhodium-catalyzed C-H activation reaction of 2-arylpyridines with 3-aryl-2-azirines.

Chem Sci 2019 Mar 8;10(9):2678-2686. Epub 2019 Jan 8.

National Creative Research Initiative Center for Catalytic Organic Reactions , Department of Chemistry , Kangwon National University , Chuncheon 24341 , Republic of Korea . Email:

A novel method for the synthesis of acylmethyl-substituted 2-arylpyridine derivatives using 3-aryl-2-azirines was developed by exploring a prototype reaction using DFT-calculations and carrying out targeted experiments guided by the calculated mechanism. 2-Azirine was initially hypothesized to ring-open at the metal center to furnish familiar metal nitrene complexes that may undergo C-N coupling. Computational studies quickly revealed and prototype experimental work confirmed that neither the formation of the expected metal nitrene complexes nor the C-N coupling were viable. Read More

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http://dx.doi.org/10.1039/c8sc05142aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419924PMC

Metal-free alkene carbooxygenation following tandem intramolecular alkoxylation/Claisen rearrangement: stereocontrolled access to bridged [4.2.1] lactones.

Chem Sci 2019 Mar 24;10(10):3123-3129. Epub 2019 Jan 24.

State Key Laboratory of Physical Chemistry of Solid Surfaces , Key Laboratory for Chemical Biology of Fujian Province , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email:

Alkene carbooxygenation has attracted considerable attention over the past few decades as this approach provides an efficient access to various oxygen-containing molecules, especially the valuable O-heterocycles. However, examples of catalytic alkene carbooxygenation a direct C-O cleavage are quite scarce, and the C-O cleavage in these cases is invariably initiated by transition metal-catalyzed oxidative addition. We report here a novel Brønsted acid-catalyzed intramolecular alkoxylation-initiated tandem sequence, which represents the first metal-free intramolecular alkoxylation/Claisen rearrangement. Read More

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http://dx.doi.org/10.1039/c9sc00079hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429610PMC

Isatin and its derivatives: a survey of recent syntheses, reactions, and applications.

Medchemcomm 2019 Mar 15;10(3):351-368. Epub 2019 Jan 15.

Department of Chemistry , University of Delhi , India . Email:

Isatin (1-indole-2,3-dione) and its derivatives represent an important class of heterocyclic compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of research work has been done regarding the synthesis, chemical properties, and biological and industrial applications of isatin. In this review, we have reported several novel methods for the synthesis of -, C2-, and C3-substituted and spiro derivatives of isatin. Read More

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http://xlink.rsc.org/?DOI=C8MD00585K
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http://dx.doi.org/10.1039/c8md00585kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438150PMC
March 2019
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Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.

ACS Med Chem Lett 2019 Apr 23;10(4):558-563. Epub 2019 Jan 23.

Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124 Parma, Italy.

We have recently discovered a family of 2,6-diaminopurine derivatives acting as DENV inhibitors by targeting an allosteric pocket on the thumb of the viral NS5 polymerase. Although the following target-based optimization allowed conversion of the hits into broad-spectrum DENV/ZIKV inhibitors, no improvement of the antiviral potency was reached. Herein, we applied a phenotypic scaffold-morphing approach to explore additional biologically relevant chemical space around the original hits by converting the flat purine derivatives into more complex chemotypes characterized by a higher degree of saturation. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466831PMC

Cannabinoids from L.: A New Tool Based on HPLC-DAD-MS/MS for a Rational Use in Medicinal Chemistry.

ACS Med Chem Lett 2019 Apr 29;10(4):539-544. Epub 2019 Jan 29.

Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.

L. represents one of the most widely used source of drugs and drugs of abuse worldwide. Its biologically active compounds are mainly cannabinoids, including Δ-tetrahydrocannabinol (THC), which is responsible for the psychoactive effects, tetrahydrocannabinolic acid (THCA), cannabinol (CBN), cannabidiol (CBD), and cannabidiolic acid (CBDA). Read More

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00571
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http://dx.doi.org/10.1021/acsmedchemlett.8b00571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466817PMC
April 2019
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Investigation on 2',3'--Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists.

ACS Med Chem Lett 2019 Apr 26;10(4):493-498. Epub 2018 Dec 26.

School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, via S. Agostino 1, 62032 Camerino, MC, Italy.

Antagonists of the purinergic P2X3 receptors represent promising drugs for the treatment of inflammation and pain. The ATP derivative 2',3'--(2,4,6-trinitrophenyl)-ATP (TNP-ATP) has been described as a potent competitive inhibitor of this receptor. In this work, the design and synthesis of novel TNP-ATP analogues bearing alkyl groups in the 2',3'-position are reported. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466514PMC

Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury.

Stem Cell Res Ther 2019 Apr 17;10(1):119. Epub 2019 Apr 17.

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.

Stem cell-based therapy appears to be a promising new candidate for acute kidney injury (AKI) management. Traditionally, it has been accepted that the mechanism underlying the regenerative effect of stem cells is based on their paracrine/endocrine activity, including release of bioactive factors that act on injured renal cells and presentation of proangiogenic, antiapoptotic, antioxidative, and immunomodulatory effects. Recently, multiple studies have confirmed that extracellular vesicles (EVs) are a kind of vesicle rich in a broad variety of biologically active molecules, including lipids, proteins, and, in particular, nucleic acids. Read More

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http://dx.doi.org/10.1186/s13287-019-1227-8DOI Listing
April 2019
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Self-supervised learning of the biologically-inspired obstacle avoidance of hexapod walking robot.

Bioinspir Biomim 2019 Apr 17. Epub 2019 Apr 17.

dept. of Computer Science, Ceske Vysoke Uceni Technicke Fakulta elektrotechnicka, Prague, CZECH REPUBLIC.

In this paper, we propose an integrated biologically inspired visual collision avoidance approach that is deployed on a real hexapod walking robot. The proposed approach is based on the Lobula Giant Movement Detector (LGMD) that is a neural network for looming stimuli detection that can be found in visual pathways of insects, such as locusts. Although a superior performance of the LGMD in the detection of intercepting objects has been shown in many collision avoiding scenarios, its direct integration with motion control is an unexplored topic. Read More

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http://iopscience.iop.org/article/10.1088/1748-3190/ab1a9c
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http://dx.doi.org/10.1088/1748-3190/ab1a9cDOI Listing
April 2019
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Mercury and methylmercury concentrations, sources and distribution in submarine canyon sediments (Capbreton, SW France): Implications for the net methylmercury production.

Sci Total Environ 2019 Apr 10;673:511-521. Epub 2019 Apr 10.

CNRS/ UNIV PAU & PAYS ADOUR/ E2S UPPA, Institut des Sciences Analytiques et de Physicochimie pour l'Environnement et les Matériaux - MIRA, UMR 5254, 64600 Anglet, France. Electronic address:

Submarine canyons are important stocks of commercial interest fish, whose consumption is one of the main monomethymercury (MeHg) exposure to humans. Currently, biogeochemistry of mercury in those biologically productive system is unknown. In this work, inorganic mercury (Hg(II)) and organic mercury (MeHg) distributions were measured in sedimentary accumulative zones (slopes and terraces) against adjacent continental shelf sediments. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.111DOI Listing

Self-assembly of graphene oxide/PEDOT:PSS nanocomposite as a novel adsorbent for uranium immobilization from wastewater.

Environ Pollut 2019 Apr 11;250:196-205. Epub 2019 Apr 11.

MOE Key Lab of Resources and Environmental System Optimization, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, PR China.

In recent years, water pollution caused by radionuclides has become a rising concern, among which uranium is a representative class of actinide element. Since hexavalent uranium, i.e. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.020DOI Listing
April 2019
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LIMPRINT: A Sociological Perspective on "Chronic Edema".

Lymphat Res Biol 2019 Apr;17(2):168-172

5 School of Social Sciences, Nottingham Trent University, Nottingham, United Kingdom.

Chronic edema is a condition that is biologically complex, distressing for patients and sociopolitically weak. Like many other complex and chronic conditions, it has a low status within health care. The result is that it has a low priority in health policy and consequently is undervalued and undertreated. Read More

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https://www.liebertpub.com/doi/10.1089/lrb.2018.0082
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http://dx.doi.org/10.1089/lrb.2018.0082DOI Listing
April 2019
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Implementing Abbreviated MRI Screening Into a Breast Imaging Practice.

AJR Am J Roentgenol 2019 Apr 17:1-4. Epub 2019 Apr 17.

1 Department of Radiology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH 44106.

The purpose of this article is to describe steps for implementing abbreviated breast MRI into a breast imaging practice. Mammographic screening for breast cancer has been the standard of care. However, breast cancer remains a leading cause of death of women. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20396
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http://dx.doi.org/10.2214/AJR.18.20396DOI Listing
April 2019
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Ultrasensitive on-site detection of biological active ricin in complex food matrices based on immunomagnetic enrichment and fluorescence switch-on nanoprobe.

Anal Chem 2019 Apr 17. Epub 2019 Apr 17.

Ricin is a highly toxic protein largely existed in castor bean, which could be used as a warfare agent due to its unique properties. As a deadenylase, inactivation of ricin means loss of toxic threat. Therefore, developing simple, accurate and sensitive on-site detection of biologically active ricin in wide types of complex matrices is more valuable. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b04458DOI Listing

Quantification of biological age as a determinant of age-related diseases in the Rotterdam Study: a structural equation modeling approach.

Eur J Epidemiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

Chronological age alone is not a sufficient measure of the true physiological state of the body. The aims of the present study were to: (1) quantify biological age based on a physiological biomarker composite model; (2) and evaluate its association with death and age-related disease onset in the setting of an elderly population. Using structural equation modeling we computed biological age for 1699 individuals recruited from the first and second waves of the Rotterdam study. Read More

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http://dx.doi.org/10.1007/s10654-019-00497-3DOI Listing

Environmentally Benign Carbon Nanodots Prepared from Lemon for the Sensitive and Selective Fluorescence Detection of Fe(III) and Tannic Acid.

J Fluoresc 2019 Apr 16. Epub 2019 Apr 16.

Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, 625021, India.

Photoluminescent carbon nanodots (CNDs) were prepared using a biocarbon source of lemon extract. The obtained CNDs are of spherical shape and are enriched with the carboxylic acid fucntionalities. CNDs exhibited a fluorescence emission at 445 nm and unveiled blue luminescence in ultraviolet excitation. Read More

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http://dx.doi.org/10.1007/s10895-019-02360-wDOI Listing
April 2019
1.927 Impact Factor

Evaluating the impacts of amino acids in the second and outer coordination spheres of Rh-bis(diphosphine) complexes for CO hydrogenation.

Faraday Discuss 2019 Apr 17. Epub 2019 Apr 17.

Physical and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.

To explore the influence of a biologically inspired second and outer coordination sphere on Rh-bis(diphosphine) CO2 hydrogenation catalysts, a series of five complexes were prepared by varying the substituents on the pendant amine in the P(Et)2CH2NRCH2P(Et)2 ligands (PEtNRPEt), where R consists of methyl ester modified amino acids, including three neutral (glycine methyl ester (GlyOMe), leucine methyl ester (LeuOMe), and phenylalanine methyl ester (PheOMe)), one acidic (aspartic acid dimethyl ester (AspOMe)) and one basic (histidine methyl ester (MeHisOMe)) amino acid esters. The turnover frequencies (TOFs) for CO2 hydrogenation for each of these complexes were compared to those of the non-amino acid containing [Rh(depp)2]+ (depp) and [Rh(PEtNMePEt)2]+ (NMe) complexes. Each complex is catalytically active for CO2 hydrogenation to formate under mild conditions in THF. Read More

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http://xlink.rsc.org/?DOI=C8FD00164B
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http://dx.doi.org/10.1039/c8fd00164bDOI Listing
April 2019
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Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population.

J Cancer Prev 2019 Mar 30;24(1):26-32. Epub 2019 Mar 30.

Department of Medicine, Hanyang University College of Medicine, Seoul, Korea.

Background: This study was conducted to explore the effect of known risk factors, focusing on risk factors including age at menarche, age at menopause, number of children, family history of breast cancer, and age at first birth according to breast density, in consideration of interaction among East-Asian women.

Methods: Case-control study with 2,123 cases and 2,121 controls with mammographic density was conducted. Using the mammographic film, breast density was measured using Breast Imaging-Reporting and Data System. Read More

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http://dx.doi.org/10.15430/JCP.2019.24.1.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453588PMC

Osteonecrosis of the femoral head: pathophysiology and current concepts of treatment.

EFORT Open Rev 2019 Mar 15;4(3):85-97. Epub 2019 Mar 15.

Clinic of Orthopaedics and Trauma Surgery, Geneva University Hospitals, Geneva, Switzerland.

Osteonecrosis of the femoral head is a disabling pathology affecting a young population (average age at treatment, 33 to 38 years) and is the most important cause of total hip arthroplasty in this population. It reflects the endpoint of various disease processes that result in a decrease of the femoral head blood flow.The physiopathology reflects an alteration of the vascularization of the fine blood vessels irrigating the anterior and superior part of the femoral head. Read More

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https://online.boneandjoint.org.uk/doi/10.1302/2058-5241.4.1
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http://dx.doi.org/10.1302/2058-5241.4.180036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440301PMC
March 2019
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Synthesis of acylglycerol derivatives by mechanochemistry.

Beilstein J Org Chem 2019 29;15:811-817. Epub 2019 Mar 29.

Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany.

In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. Read More

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https://www.beilstein-journals.org/bjoc/articles/15/78
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http://dx.doi.org/10.3762/bjoc.15.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444433PMC
March 2019
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Biologically inspired approaches to enhance human organoid complexity.

Development 2019 Apr 16;146(8). Epub 2019 Apr 16.

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

Organoids are complex three-dimensional organ-like model systems. Human organoids, which are derived from human pluripotent stem cells or primary human donor tissue, have been used to address fundamental questions about human development, stem cell biology and organ regeneration. Focus has now shifted towards implementation of organoids for biological discovery and advancing existing systems to more faithfully recapitulate the native organ. Read More

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http://dev.biologists.org/lookup/doi/10.1242/dev.166173
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http://dx.doi.org/10.1242/dev.166173DOI Listing
April 2019
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Biomimetic synthetic studies on meroterpenoids from the marine sponge Aka coralliphaga: Divergent total syntheses of siphonodictyal B, liphagal and corallidictyals A-D.

Bioorg Med Chem 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia. Electronic address:

The marine sponge Aka coralliphaga is a rich source of biologically active and structurally interesting meroterpenoids. Inspired by these natural products, we have used biosynthetic speculation to devise biomimetic syntheses of siphonodictyal B, liphagal and corallidictyals A-D from sclareolide. This work resulted in the development of new cascade reactions in the synthesis of liphagal, the reassignment of the structure of siphonodictyal B, and the realisation that corallidictyals A and B are possibly isolation artefacts. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.02.038DOI Listing
February 2019

A gestational vulnerability window for smoking exposure and the increased risk of preterm birth: how timing and intensity of maternal smoking matter.

Reprod Health 2019 Apr 16;16(1):43. Epub 2019 Apr 16.

School of Public Health, Department of Family Science, University of Maryland, 4200 Valley Drive, College Park, MD, 20742, USA.

Background: Reducing the incidence of preterm birth is a national priority. Maternal cigarette smoking is strongly and consistently associated with preterm birth. The objective of this study was to examine prenatal exposure based on combined measures of timing (by trimester) and intensity level (the number of cigarettes smoked per day) of maternal smoking to identify a pregnancy period with the highest risk of preterm birth. Read More

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https://reproductive-health-journal.biomedcentral.com/articl
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http://dx.doi.org/10.1186/s12978-019-0705-xDOI Listing
April 2019
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In vitro cytotoxicity, cellular uptake, reactive oxygen species and cell cycle arrest studies of novel ruthenium(II) polypyridyl complexes towards A549 lung cancer cell line.

Drug Chem Toxicol 2019 Apr 17:1-11. Epub 2019 Apr 17.

b School of Food Science and Environmental Health, Technological University Dublin , Dublin , Ireland.

Ruthenium(II) polypyridyl complexes have displayed some promising biological responses against a variety of cancers and have emerged as a potential candidate that can show significant antitumor activity. Three ruthenium(II) polypyridyl complexes were biologically evaluated in vitro against the A549 cancer cell line. The complexes were selected based on initial DNA intercalation studies and MTT viability screening and were selected based on the most promising candidates, the [Ru(bpy)o-CPIP]. Read More

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http://dx.doi.org/10.1080/01480545.2019.1589492DOI Listing

Treatment train for mature landfill leachates: Optimization studies.

Sci Total Environ 2019 Apr 4;673:470-479. Epub 2019 Apr 4.

Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials (LSRE-LCM), Departamento de Engenharia Química, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. Electronic address:

In the current study, a treatment train strategy for urban mature leachates, comprising biological and physicochemical processes, was tested for full legal compliance. The leachate presents a high organic and nitrogen content (1.1 g C/L; 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193154
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.027DOI Listing
April 2019
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Glucosamine-6-phosphate synthase inhibiting C3-β-cholesterol tethered spiro heterocyclic conjugates: Synthesis and their insight of DFT and docking study.

Bioorg Chem 2019 Apr 9;88:102920. Epub 2019 Apr 9.

Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. Electronic address:

A series of novel covalent cholesterol-spiro pyrrolidine/pyrrolizidine heterocyclic hybrids possessing biologically active oxindole, indanedione, and acenaphthylene-1-one have been synthesized by the reaction of C3-β-cholesteroalacrylate with heterocyclic di- and tri-ketones. All the sixteen compounds were obtained as a single isomer in good yield through a stereo- and regio- selective 1,3-dipolar cycloaddition methodology. Stereochemistry of the spiranic cycloadducts has been established by spectroscopic analysis and the regioselectivity outcome of the spiro adducts has been accomplished by DFT calculations at B3LYP/6-31G (d,p) level study. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102920DOI Listing

Effects of UV disinfection on phenotypes and genotypes of antibiotic-resistant bacteria in secondary effluent from a municipal wastewater treatment plant.

Water Res 2019 Mar 29;157:546-554. Epub 2019 Mar 29.

Agricultural Clean Watershed Research Group, Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, 100081, PR China. Electronic address:

To elucidate the effects of UV disinfection on antibiotic resistance in biologically-treated wastewater, we investigated the antibiotic resistance profiles, species of cultivable heterotrophic bacteria, and antibiotic-resistance genes (ARGs) in antibiotic-resistant bacteria before and after treatment. UV disinfection greatly changed the bacterial community structure and the antibiotic resistance in wastewater. The antibiotic resistance in wastewater samples was strongly associated with the bacterial community. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00431354193019
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http://dx.doi.org/10.1016/j.watres.2019.03.079DOI Listing
March 2019
3 Reads