84,539 results match your criteria Biologically Inspired Cognitive Architectures[Journal]


[Spinach and quinoa - prospective food sources of biologically active substances].

Vopr Pitan 2020 16;89(2):100-106. Epub 2020 Mar 16.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.

Formally, phytoadaptogens extracted mainly from medicinal plants are not food substances, and their use in preventive nutrition is significantly limited. However, screening studies can detect phytoadaptogens in food plants, however in much smaller quantities. For example, phytoecdysteroids are biologically active substances (BAS), used to relieve chronic fatigue syndrome, reduce nervous and muscle fatigue, improve memory and attention processes. Read More

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http://dx.doi.org/10.24411/0042-8833-2020-10020DOI Listing

[The content of essential and toxic microelements in the organs of mice of various lines receiving a high-carb high-fat diet and supplemented with quercetin].

Vopr Pitan 2020 16;89(2):28-45. Epub 2020 Mar 16.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.

Quercetin (Q) is known to be a powerful chelating agent for metal ions. Due to this property, Q, when ingested, is able to intervene actively in microelement homeostasis. The assessment of the possible significance of these effects for the dietary use of Q in obesity is complicated by the fact that in obese patients there are numerous changes in mineral metabolism and microelement homeostasis due to the pathogenesis of the disease. Read More

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http://dx.doi.org/10.24411/0042-8833-2020-10014DOI Listing

Complementary Role of Co- and Post-Translational Events in Protein Biogenesis.

J Phys Chem B 2020 May 26. Epub 2020 May 26.

The relation between co- and post-translational protein folding and aggregation in the cell is poorly understood. Here, we employ a combination of fluorescence anisotropy decays in the frequency domain, fluorescence-detected solubility assays and NMR spectroscopy to explore the role of the ribosome in protein folding within a biologically relevant context. First, we find that a primary function of the ribosome is to promote cotranslational nascent-protein solubility, thus supporting cotranslational folding even in the absence of molecular chaperones. Read More

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http://dx.doi.org/10.1021/acs.jpcb.0c03039DOI Listing

Viridistratins A-C, Antimicrobial and Cytotoxic Benzo[]fluoranthenes from Stromata of (Hypoxylaceae, Ascomycota).

Biomolecules 2020 May 23;10(5). Epub 2020 May 23.

Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.

During the course of our search for novel biologically active metabolites from tropical fungi, we are using chemotaxonomic and taxonomic methodology for the preselection of interesting materials. Recently, three previously undescribed benzo[]fluoranthenes (-) together with the known derivatives truncatones A and C (, ) were isolated from the stromata of the recently described species collected in Thailand. Their chemical structures were elucidated by means of spectral methods, including nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HR-MS). Read More

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http://dx.doi.org/10.3390/biom10050805DOI Listing

The Influence of Different Forms of Silver on Selected Pathogenic Bacteria.

Materials (Basel) 2020 May 23;13(10). Epub 2020 May 23.

Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University in Torun, Wileńska 4, 87-100 Torun, Poland.

The application of silver nanoparticles as an antibacterial agent is becoming more common. Unfortunately, their effect on microorganisms is still not fully understood. Therefore, this paper attempts to investigate the influence of silver ions, biologically synthesized silver nanoparticles and nanoparticles functionalized with antibiotics on molecular bacteria profiles. Read More

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http://dx.doi.org/10.3390/ma13102403DOI Listing

Temporary Membrane Permeabilization via the Pore-Forming Toxin Lysenin.

Toxins (Basel) 2020 May 22;12(5). Epub 2020 May 22.

Department of Physics, Boise State University, Boise, ID 83725, USA.

Pore-forming toxins are alluring tools for delivering biologically-active, impermeable cargoes to intracellular environments by introducing large conductance pathways into cell membranes. However, the lack of regulation often leads to the dissipation of electrical and chemical gradients, which might significantly affect the viability of cells under scrutiny. To mitigate these problems, we explored the use of lysenin channels to reversibly control the barrier function of natural and artificial lipid membrane systems by controlling the lysenin's transport properties. Read More

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http://dx.doi.org/10.3390/toxins12050343DOI Listing

Chemical Profile and Antioxidant Activity of the Kombucha Beverage Derived from White, Green, Black and Red Tea.

Antioxidants (Basel) 2020 May 22;9(5). Epub 2020 May 22.

Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 24 Broniewskiego Street, 71-460 Szczecin, Poland.

Kombucha is a fermented tea beverage prepared as a result of the symbiotic nature of bacterial cultures and yeast, the so-called SCOBY (). Kombucha is characterised by rich chemical content and healthy properties. It includes organic acids, minerals and vitamins originating mainly from tea, amino acids, and biologically active compounds-polyphenols in particular. Read More

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http://dx.doi.org/10.3390/antiox9050447DOI Listing

Isolation, Characterization and Chemical Synthesis of Large Spectrum Antimicrobial Cyclic Dipeptide (l-leu-l-pro) from V16R3Y1 Bacteria Extracts. A Novel H NMR Metabolomic Approach.

Antibiotics (Basel) 2020 May 21;9(5). Epub 2020 May 21.

LR03ES03, Laboratoire de Microorganismes et Biomolécules Actives, Faculté des Sciences de Tunis, Université Tunis Manar, Tunis 2092, Tunisia.

Streptomyces is the most frequently described genus of Actinomycetes, a producer of biologically active secondary metabolites. Indeed, the Streptomyces species produces about 70% of antibiotics and 60% of antifungal molecules used in agriculture. Our study was carried out with the goal of isolating and identifying antimicrobial secondary metabolites from V16R3Y1 isolated from the date palm rhizosphere (southern Tunisia). Read More

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http://dx.doi.org/10.3390/antibiotics9050270DOI Listing

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner.

Int J Mol Sci 2020 May 21;21(10). Epub 2020 May 21.

Department of Medicine and Surgery-DIMEC, Unit of Biomedical, Biotechnological and Translational Sciences (S.BI.BI.T.), Laboratory of Regenerative Morphology and Bioartificial Structures (Re.Mo.Bio.S. Lab.), University of Parma, 43121 Parma, Italy.

Endocrine disruptors (EDs) are chemicals that contribute to health problems by interfering with the physiological production and target effects of hormones, with proven impacts on a number of endocrine systems including the thyroid gland. Exposure to EDs has also been associated with impairment of the reproductive system and incidence in occurrence of obesity, type 2 diabetes, and cardiovascular diseases during ageing. SCREENED aims at developing in vitro assays based on rodent and human thyroid cells organized in three different three-dimensional (3D) constructs. Read More

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http://dx.doi.org/10.3390/ijms21103648DOI Listing

Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole.

Int J Mol Sci 2020 May 21;21(10). Epub 2020 May 21.

Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland.

Two novel silver(I) complexes of the biologically active ligand miconazole in the form of Ag(MCZ)X (MCZ = 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1-imidazole]; X = NO (), ClO ()) were synthesized and fully characterized. The complexes were obtained by reactions of Ag(I) salts with miconazole (MCZ). Silver(I) complexes were characterized by elemental analysis, H-NMR and infrared (IR) spectroscopy, electrospray ionization (ESI)-MS spectrometry, and X-ray-crystallography. Read More

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http://dx.doi.org/10.3390/ijms21103629DOI Listing

Bayesian Non-linear Support Vector Machine for High-Dimensional Data with Incorporation of Graph Information on Features.

Proc IEEE Int Conf Big Data 2019 Dec 24;2019:4874-4882. Epub 2020 Feb 24.

Department of Biostatistics, Epidemiology and Informatics The University of Pennsylvania, Philadelphia, PA, 19104.

Support vector machine (SVM) is a popular classification method for analysis of high dimensional data such as genomics data. Recently a number of linear SVM methods have been developed to achieve feature selection through either frequentist regularization or Bayesian shrinkage, but the linear assumption may not be plausible for many real applications. In addition, recent work has demonstrated that incorporating known biological knowledge, such as those from functional genomics, into the statistical analysis of genomic data offers great promise of improved predictive accuracy and feature selection. Read More

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http://dx.doi.org/10.1109/bigdata47090.2019.9006473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243270PMC
December 2019

Anti-inflammatory, Antiplatelet Aggregation, and Antiangiogenesis Polyketides from : Toward an Understating of Its Biological Activities and Potential Applications.

ACS Omega 2020 May 6;5(19):11092-11099. Epub 2020 May 6.

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

The ethyl acetate extract of an endophyte exhibited anti-inflammatory activity at a concentration of <10 μg/mL. By bioassay-guided fractionation, one new compound, named epicorepoxydon A (), and one unusual bioactive compound, 6-(hydroxymethyl)benzene-1,2,4-triol (), together with six known compounds, were isolated from . The structures of all isolates were established by spectroscopic analyses. Read More

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http://dx.doi.org/10.1021/acsomega.0c01000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241018PMC

High-Throughput and Sensitive Analysis of Free and Total 8-Isoprostane in Urine with Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry.

ACS Omega 2020 May 11;5(19):10919-10926. Epub 2020 May 11.

Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, Georgia 30341, United States.

Oxidative stress (OS) plays a major role in the pathogenesis of various diseases in humans. OS is a result of an imbalance between reactive oxygen species (ROS) and the biologically available antioxidants that prevent or repair damage that ROS inflict on the host cells. ROS are naturally generated during normal mitochondrial respiration and by oxidative burst during the immune response. Read More

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http://dx.doi.org/10.1021/acsomega.0c00661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241033PMC

Stereotactic body radiation therapy for salvage treatment of recurrent non-small cell lung cancer.

Pract Radiat Oncol 2020 May 23. Epub 2020 May 23.

University of Virginia / Riverside, Radiosurgery Center, , Newport News, VA, USA.

Purpose/objectives: This study analyzes the outcomes and toxicity of stereotactic body radiation therapy (SBRT) as salvage treatment for recurrent non-small cell lung cancer (NSCLC).

Materials/methods: This retrospective analysis considered patients treated with thoracic SBRT and a history of prior external beam radiation therapy (EBRT), SBRT, or surgical resection for NSCLC. Follow-up included PET and CT imaging at 2-3 month intervals. Read More

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http://dx.doi.org/10.1016/j.prro.2020.05.005DOI Listing

Mismatch repair deficiency in metastatic prostate cancer: Response to PD-1 blockade and standard therapies.

PLoS One 2020 26;15(5):e0233260. Epub 2020 May 26.

Division of Oncology, Department of Medicine, University of Washington, Seattle, WA, United States of America.

Background: While response rates to anti-PD1 therapy are low in unselected metastatic castration resistant prostate cancer (mCRPC) patients, those with inactivating mutations in mismatch repair (MMR) genes (i.e. MMR deficiency; MMRd) or microsatellite instability (MSI) are thought likely to respond favorably. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233260PLOS

Catalytic Asymmetric [3 + 2] Annulation via Indolyl Copper-Allenylidene Intermediates: Diastereo- and Enantioselective Assembly of Pyrrolo[1,2-]indoles.

Org Lett 2020 May 26. Epub 2020 May 26.

School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

A catalytic asymmetric decarboxylative [3 + 2] annulation via indolyl copper-allenylidene amphiphilic intermediates has been developed. This protocol offers a straightforward method for the synthesis of biologically important pyrrolo[1,2-]indoles bearing contiguous quaternary and tertiary stereogenic centers with excellent diastereo- and enantioselectivities (up to >20:1 dr and >99% ee). In addition, the diversity-oriented synthesis of pyrrolo[1,2-]indoles was achieved via versatile transformations of the alkyne-containing cycloadducts. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01594DOI Listing

Kratom (Mitragyna speciosa): worldwide issues.

Curr Opin Psychiatry 2020 Jul;33(4):312-318

Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

Purpose Of Review: To inform readers about the increasingly popular Western dietary supplement, kratom (Mitragyna speciosa) and how the products are available in the Western world compared with traditional Southeast Asian use. Kratom has been traditionally used for increasing stamina of outdoor laborers (farmers), mood enhancement, pain, and opium addiction. Interestingly, kratom has been reported to have a paradoxical effect in that stimulant feelings, and sedative feelings can be obtained depending on the amount utilized. Read More

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http://dx.doi.org/10.1097/YCO.0000000000000621DOI Listing

Aerobic Acylarylation of α,β-Unsaturated Amides with Aldehydes.

Org Lett 2020 May 26. Epub 2020 May 26.

School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India.

Herein, we illustrate that molecular oxygen (O) is capable of promoting oxidative radical acylarylation of olefins with aliphatic aldehydes to afford acylated oxindoles in good yield (up to 97%). The key aspect of the process is the utilization of aldehyde auto-oxidation in developing aerobic radical olefin acylarylation. Kinetic studies confirm a lag phase for the reaction. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c01336DOI Listing

Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides.

J Org Chem 2020 May 26. Epub 2020 May 26.

5-Cyanoimidazole was identified as a new ligand for nickel-catalyzed cross-electrophile couplings by screening a diverse set of pharmaceutical compound library. A strategic screening approach led to the discovery of this novel ligand; which was successfully applied in the preparation of various alkylated arene products with good to high yields. Furthermore, the properties of this ligand allowed expanding the scope of reductive couplings to challenging substrates, such as sterically hindered neopentyl halides, which are known to generate motifs that are prevalent in biologically active molecules. Read More

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http://dx.doi.org/10.1021/acs.joc.0c00549DOI Listing

Establishment of Murine Infection Models with Biological Clones of Dengue Viruses Derived from a Single Clinical Viral Isolate.

Virol Sin 2020 May 25. Epub 2020 May 25.

CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 200031, Shanghai, China.

Dengue virus (DENV) is a single-stranded RNA virus transmitted by mosquitoes in tropical and subtropical regions. It causes dengue fever, dengue hemorrhagic fever and dengue shock syndrome in patients. Each year, 390 million people are estimated to be infected by four serotypes of dengue virus, creating a great burden on global public health and local economy. Read More

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http://dx.doi.org/10.1007/s12250-020-00229-yDOI Listing

Antitumor efficacy of BAFF-R targeting CAR T cells manufactured under clinic-ready conditions.

Cancer Immunol Immunother 2020 May 25. Epub 2020 May 25.

Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.

B-cell malignancies can potentially be cured by CD19 chimeric antigen receptor (CAR) T-cell therapy. Although clinical response rates can be up to 93% in acute lymphoblastic leukemia, treatment-related antigen loss and lack of therapeutic persistence contribute to disease relapse. These shortcomings of current CAR T-cell therapy indicate the need for biologically relevant target selection and for improving the efficacy and persistence of the CAR T cells, which we have addressed by developing a novel B-cell activating factor receptor (BAFF-R) CAR T-cell therapy with improved therapeutic persistence. Read More

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http://dx.doi.org/10.1007/s00262-020-02614-8DOI Listing

Illumination guidelines for ultrafast pump-probe experiments by serial femtosecond crystallography.

Nat Methods 2020 May 25. Epub 2020 May 25.

Max-Planck-Institut für Medizinische Forschung, Heidelberg, Germany.

Time-resolved crystallography with X-ray free-electron lasers enables structural characterization of light-induced reactions on ultrafast timescales. To be biologically and chemically relevant, such studies must be carried out in an appropriate photoexcitation regime to avoid multiphoton artifacts, a common issue in recent studies. We describe numerical and experimental approaches to determine how many photons are needed for single-photon excitation in microcrystals, taking into account losses by scattering. Read More

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http://dx.doi.org/10.1038/s41592-020-0847-3DOI Listing

Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.

Nat Protoc 2020 May 25. Epub 2020 May 25.

European Molecular Biology Laboratory (EMBL) Grenoble, Grenoble, France.

Long noncoding RNAs (lncRNAs) are recently discovered transcripts that regulate vital cellular processes, such as cellular differentiation and DNA replication, and are crucially connected to diseases. Although the 3D structures of lncRNAs are key determinants of their function, the unprecedented molecular complexity of lncRNAs has so far precluded their 3D structural characterization at high resolution. It is thus paramount to develop novel approaches for biochemical and biophysical characterization of these challenging targets. Read More

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http://dx.doi.org/10.1038/s41596-020-0323-7DOI Listing

Accounting for cell type hierarchy in evaluating single cell RNA-seq clustering.

Authors:
Zhijin Wu Hao Wu

Genome Biol 2020 May 25;21(1):123. Epub 2020 May 25.

Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, 30322, GA, USA.

Cell clustering is one of the most common routines in single cell RNA-seq data analyses, for which a number of specialized methods are available. The evaluation of these methods ignores an important biological characteristic that the structure for a population of cells is hierarchical, which could result in misleading evaluation results. In this work, we develop two new metrics that take into account the hierarchical structure of cell types. Read More

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http://dx.doi.org/10.1186/s13059-020-02027-xDOI Listing

Endocrine, Metabolic and Pharmacological Effects of Thyronamines (TAM), Thyroacetic Acids (TA) and Thyroid Hormone Metabolites (THM) - Evidence from in vitro, Cellular, Experimental Animal and Human Studies.

Exp Clin Endocrinol Diabetes 2020 May 25. Epub 2020 May 25.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany Institut für Experimentelle Endokrinologie, Berlin, Germany.

Thyroid hormone metabolites (THM) with few or no iodine substituents such as 3,5-T2, the thyronamines 3-T1AM and T0AM, and their oxidation products, the thyroacetic acids (TA) formed by monoamine oxidases, have recently attracted major interest due to their metabolic actions which are in part distinct from those of the classical thyromimetic hormone T3, the major ligand of T3 receptors. This review compiles and discusses effects of 3,5-T2, TAM and TA reported for thyrocytes, pancreatic islets and hepatocytes as well as findings from studies in mouse models after single or repeated administration of pharmacological doses of these agents. Comparison of the 3,5-T2 effects on the transcriptome with not yet published proteome data in livers of obese mice on high fat diet indicate a distinct anti-steatotic effect of this THM. Read More

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http://dx.doi.org/10.1055/a-1139-9200DOI Listing

A natural cyanobacterial protein C-phycoerythrin as an HS selective optical probe in aqueous systems.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 12;239:118469. Epub 2020 May 12.

Applied Phycology and Biotechnology Division, CSIR - Central Salt and Marine Chemicals Research Institute, Gijubhai Badheka Marg, Bhavnagar 364002, Gujarat, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India. Electronic address:

A naturally fluorescent cyanobacterial protein C-phycoerythrin (CPE) was investigated as a fluorescent probe for biologically and environmentally important hydrosulphide (HS) ion. It was selective for HS amongst a large anion screen and the optical response was rapid. Sequential UV-visible titration showed considerable peak shift and attenuation with increasing [HS] while fluorescence titration proved that HS quenched CPE fluorescence in a concentration dependent manner. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118469DOI Listing

Catalytic Enantiodivergent Michael Addition by Subtle Adjustment of Achiral Amino Moiety of Dipeptide Phosphines.

iScience 2020 May 6;23(6):101138. Epub 2020 May 6.

Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200438, P. R. China; Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, P. R. China. Electronic address:

Over the past decades, asymmetric catalysis has been intensely investigated as a powerful tool for the preparation of numerous chiral biologically active compounds. However, developing general and practical strategies for preparation of both enantiomers of a chiral molecule via asymmetric catalysis is still a challenge, particularly when the two enantiomers of a chiral catalyst are not easily prepared from natural chiral sources. Inspired by the biologic system, we report herein an unprecedented catalytic enantiodivergent Michael addition of pyridazinones to enones by subtle adjustment of achiral amino moiety of dipeptide phosphine catalysts. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101138DOI Listing

Operating during COVID-19: Is there a risk of viral transmission from surgical smoke during surgery?

Can J Surg 2020 05 25;63(3):E299-E301. Epub 2020 May 25.

From the Department of General Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ont.

Summary: The World Health Organization declared a pandemic when coronavirus disease 2019 (COVID-19) started to sweep the globe. Growing concerns for the safety of health care workers was raised when up to 80% of people with COVID-19 showed mild or no symptoms at all. Some surgical procedures will be inevitable during the pandemic, and proper safety measures must be in place to avoid transmission risks. Read More

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http://dx.doi.org/10.1503/cjs.007020DOI Listing

Evoked-potential audiogram variability in a group of wild Yangtze finless porpoises (Neophocaena asiaeorientalis asiaeorientalis).

J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2020 May 24. Epub 2020 May 24.

Key Laboratory of Aquatic Biodiversity and Conservation of the Chinese Academy of Sciences, Institute of Hydrobiology of the Chinese Academy of Sciences, 7 South Donghu Road, Wuhan, 430072, China.

Hearing is considered the primary sensory modality of cetaceans and enables their vital life functions. Information on the hearing sensitivity variability within a species obtained in a biologically relevant wild context is fundamental to evaluating potential noise impact and population-relevant management. Here, non-invasive auditory evoked-potential methods were adopted to describe the audiograms (11. Read More

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http://dx.doi.org/10.1007/s00359-020-01426-6DOI Listing

Short communication: Menaquinone-4 (vitamin K) induces proliferation responses in bovine peripheral blood mononuclear cells.

J Dairy Sci 2020 May 21. Epub 2020 May 21.

Laboratory of Animal Breeding and Reproduction, Research Faculty of Agriculture, Hokkaido University, Kita-ku Kita 9 Nishi 9, Sapporo 060-8589, Japan; Global Station for Food, Land and Water Resources, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo 060-0815, Japan.

The effects of vitamin K (VK) on immune cells in ruminants are yet to be fully investigated. The objective of this study was to examine the effects of VK on peripheral blood mononuclear cells (PBMC) in Holstein dairy cows. A cell proliferation assay was performed to evaluate the effect of menaquinone-4 (MK-4, the biologically active form of VK) on immune response of PBMC. Read More

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http://dx.doi.org/10.3168/jds.2019-17987DOI Listing

Increased Vascularity in the Neonatal versus Adult Meniscus: Evaluation with Magnetic Resonance Imaging.

Cartilage 2020 May 23:1947603520923143. Epub 2020 May 23.

Miami Orthopedics and Sports Medicine Institute, Baptist Health South Florida, Miami, FL, USA.

. Quantification of meniscus vascularity has been limited with previous techniques, and minimal data exist describing differential vascular zones in the skeletally immature meniscus. The objective of this study is to use quantitative contrast-enhanced magnetic resonance imaging (MRI) to compare meniscal vascularity in neonatal specimens with adults. Read More

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http://dx.doi.org/10.1177/1947603520923143DOI Listing

St. John's Wort Herbal Teas - Biological Potential and Chemometric Approach to Quality Control.

Plant Foods Hum Nutr 2020 May 24. Epub 2020 May 24.

Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, 21000, Serbia.

St. John's wort has been used for centuries in traditional medicine of many cultures, and nowadays it is well-known as a clinically important antidepressant drug. Considering the rising market demand for Hyperici herba, quality control of crude drug is of paramount importance. Read More

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http://dx.doi.org/10.1007/s11130-020-00823-1DOI Listing

Chemoenzymatic conversion of Sorghum durra stalk into furoic acid by a sequential microwave-assisted solid acid conversion and immobilized whole-cells biocatalysis.

Bioresour Technol 2020 May 5;311:123474. Epub 2020 May 5.

Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, PR China.

In this study, chemoenzymatic conversion of Sorghum durra stalk (SDS) into furoic acid was developed by a sequential microwave-assisted solid acid conversion and immobilized whole-cells biocatalysis method. Dry dewaxed SDS (75 g/L) was catalyzed into furfural at 57.8% yield with heterogeneous Sn-argil (2. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123474DOI Listing

Staphylococcus xylosus VITURAJ10: Pyrrolo [1,2α] pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl) (PPDHMP) producing, potential probiotic strain with antibacterial and anticancer activity.

Microb Pathog 2020 May 21:104259. Epub 2020 May 21.

School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India. Electronic address:

In the present study bacterial strain (VITURAJ10), isolated from goat milk was characterised for its probiotic potential. The various probiotic traits included tolerance to acidic pH (up to pH 3), bile salts (0.3%) and transit gut environment (simulated with digestive juices such as pepsin, Oxgall and pancreatin). Read More

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http://dx.doi.org/10.1016/j.micpath.2020.104259DOI Listing

Factor analyses of metabolic syndrome: A systematic review with special reference to Asian Indians.

Diabetes Metab Syndr 2020 May 11;14(4):697-705. Epub 2020 May 11.

Biomedical Research Laboratory, Department of Anthropology, Visva-Bharati (A Central University and an Institution of National Importance), Santiniketan, West Bengal, India. Electronic address:

Background: Metabolic syndrome is the constellation of cardiovascular disease risk factors and a growing public health issue affecting more than 20% of world population. Factor analysis is a powerful mathematical tool in exploring the underlying factors of any chronic diseases. Although it is most often criticized for its contrasting results for a common expression differently interpreted by the researchers yet fit the original data equally well. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.05.014DOI Listing

The conjugation of targeted therapy and image-guided phototdynamic therapy of cancer in vitro and in vivo.

Bioorg Chem 2020 May 4;100:103822. Epub 2020 May 4.

Beijing National Laboratory for Molecular Science, CAS Research/Education Center for Excellence in Molecule Science. Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address:

Integration of multi-functional diagnosis and treatment competencies can improve effect of the drug and its visual distribution to the location of tumor focus site, and play a pivotal role by visualizing the tumor size in the assessment of chemotherapy. With the objective of developing integrated multi-therapeutic and diagnostic agent that could target the kinase receptor with high expression in tumor cells, herein, a biologically releasable drug-drug conjugate compound 9 with dual therapeutic and diagnostic effects was designed, synthesized and evaluated for pharmacodynamics and diagnostic functions in vitro and in vivo. The results of antitumor effects evaluations and compound 9 visual imaging indicated that compound 9 not only improved the anti-proliferative activity of chemotherapy and photodynamic treatment (PDT) in vitro and in vivo compared with those of compound 8 and PpIX but also allowed the photodynamic diagnosis (PDD). Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103822DOI Listing

Effect of biocrusts on bacterial community composition at different soil depths in Mediterranean semi-arid ecosystems.

Sci Total Environ 2020 May 4;733:138613. Epub 2020 May 4.

Department of Agronomy, University of Almeria, E-04120 Almería, Spain; Center for Intensive Mediterranean Agrosystems and Agri-food Biotechnology (CIAIMBITAL), University of Almeria, E-04120 Almería, Spain.

This study analyzed the influence of biocrusts on the chemical properties and bacterial diversity and community composition in the underlying soils along a depth gradient (the biocrust (C1), middle (S2) and deep (S3) soil layers) in two semi-arid Mediterranean ecosystems. Organic carbon, pH, electric conductivity and calcium carbonate content were estimated by wet oxidation, potentiometrically (pHmeter), with a conductivity-meter and volumetrically with a Bernard calcimeter, respectively. Bacterial diversity and community composition were estimated by 16S rRNA gene high-throughput amplicon sequencing. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138613DOI Listing

Selected edible medicinal mushrooms from Pleurotus genus as an answer for human civilization diseases.

Food Chem 2020 May 16;327:127084. Epub 2020 May 16.

Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland. Electronic address:

Edible mushrooms are classified as a functional food. The study aimed to initiate in vitro cultures of selected species of Pleurotus: P. citrinopileatus, P. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127084DOI Listing

Large-scale Discovery of Non-conventional Peptides in Maize and Arabidopsis Through an Integrated Peptidogenomic Pipeline.

Mol Plant 2020 May 20. Epub 2020 May 20.

National Key Laboratory of Wheat and Maize Crop Science, Collaborative Innovation Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University, Zhengzhou 450002, China. Electronic address:

Non-conventional peptides (NCPs), which include small open reading frame-encoded peptides, play critical roles in fundamental biological processes. Here we developed an integrated peptidogenomic pipeline using high-throughput mass spectra to probe a customized six-frame translation database and applied it to large-scale identification of NCPs in plants. Altogether, 1,993 and 1,860 NCPs were unambiguously identified in maize and Arabidopsis, respectively. Read More

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http://dx.doi.org/10.1016/j.molp.2020.05.012DOI Listing

Antiproliferative activity of side-chain truncated vitamin D analogs (PRI-1203 and PRI-1204) against human malignant melanoma cell lines.

Eur J Pharmacol 2020 May 20:173170. Epub 2020 May 20.

Department of Histology, Faculty of Medicine, Medical University of Gdańsk, 1a Debinki, Gdańsk, 80-211, Poland. Electronic address:

Vitamin D compounds are versatile molecules widely considered as promising agents in cancer prevention and treatment, including melanoma. Previously we investigated series of double point modified vitamin D analogs as well as non-calcemic 20S-hydroxyvitamin D and 21-hydroxypregnacalciferol as to their anti-melanoma activity. Surprisingly, short side-chain vitamin D analogs were found to be biologically active compounds. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173170DOI Listing

Biocompatible nanovesicular drug delivery systems with targeting potential for autoimmune diseases.

Curr Pharm Des 2020 May 23. Epub 2020 May 23.

Delhi Pharmaceutical Sciences and Research University, New Delhi. India.

Autoimmune diseases are collectively addressed as chronic conditions initiated by loss of one's immunological tolerance, where body treats its own cells as foreigners or self-antigens. These hay-wired antibodies or immunologically capable cells lead to variety of disorders like rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, multiple sclerosis and recently included neurodegenerative diseases like Alzheimer's, Parkinsonism and testicular cancer triggered T-cells induced autoimmune response in testes and brain. Conventional treatments for autoimmune diseases possess several downsides due to unfavourable pharmacokinetic behaviour of drug, reflected by low bioavailability, rapid clearance, offsite toxicity, restricted targeting ability and poor therapeutic outcomes. Read More

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http://dx.doi.org/10.2174/1381612826666200523174108DOI Listing

Linked patterns of biological and environmental covariation with brain structure in adolescence: a population-based longitudinal study.

Mol Psychiatry 2020 May 22. Epub 2020 May 22.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Adolescence is a period of major brain reorganization shaped by biologically timed and by environmental factors. We sought to discover linked patterns of covariation between brain structural development and a wide array of these factors by leveraging data from the IMAGEN study, a longitudinal population-based cohort of adolescents. Brain structural measures and a comprehensive array of non-imaging features (relating to demographic, anthropometric, and psychosocial characteristics) were available on 1476 IMAGEN participants aged 14 years and from a subsample reassessed at age 19 years (n = 714). Read More

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http://dx.doi.org/10.1038/s41380-020-0757-xDOI Listing

A cysteine selenosulfide redox switch for protein chemical synthesis.

Nat Commun 2020 May 22;11(1):2558. Epub 2020 May 22.

Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59000, Lille, France.

The control of cysteine reactivity is of paramount importance for the synthesis of proteins using the native chemical ligation (NCL) reaction. We report that this goal can be achieved in a traceless manner during ligation by appending a simple N-selenoethyl group to cysteine. While in synthetic organic chemistry the cleavage of carbon-nitrogen bonds is notoriously difficult, we describe that N-selenoethyl cysteine (SetCys) loses its selenoethyl arm in water under mild conditions upon reduction of its selenosulfide bond. Read More

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http://dx.doi.org/10.1038/s41467-020-16359-6DOI Listing

[Lysozyme-induced nephropathy: A rare cause of renal failure in chronic myelomonocytic leukemia].

Ann Pathol 2020 May 19. Epub 2020 May 19.

Service d'anatomie et cytologie pathologiques, CHU Pontchaillou, 2, rue Henri le Guilloux, 35033 Rennes cedex 9, France.

Introduction: Lysozyme-induced nephropathy is a rare and unknown complication of chronic myelomonocytic leukemia with overproduction of lysozyme by tumoral cells leading to proximal tubular cells injuries. The present case reports a lysozyme nephropathy secondary to chronic myelomonocytic leukemia.

Observation: We reported a case of a 82-years-old woman who presented an acute renal failure in a context of diarrhea and vomiting. Read More

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http://dx.doi.org/10.1016/j.annpat.2020.04.001DOI Listing

Lectins from the Edible Mushroom and Their Therapeutic Potentials.

Molecules 2020 May 20;25(10). Epub 2020 May 20.

School of Pharmacy, Bandung Institute of Technology, Ganesha 10, Bandung 40132, Indonesia.

The mushroom secretes biologically active compounds and proteins with benefits for human health. Most reported proteins from are tyrosinases and lectins. Lectins are of therapeutic or pharmaceutical interest. Read More

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http://dx.doi.org/10.3390/molecules25102368DOI Listing

Functional Polymers Structures for (Bio)Sensing Application-A Review.

Polymers (Basel) 2020 May 18;12(5). Epub 2020 May 18.

Faculty of Chemistry, Wrocław University of Science and Technology, 50-137 Wrocław, Poland.

In this review we present polymeric materials for (bio)sensor technology development. We focused on conductive polymers (conjugated microporous polymer, polymer gels), composites, molecularly imprinted polymers and their influence on the design and fabrication of bio(sensors), which in the future could act as lab-on-a-chip (LOC) devices. LOC instruments enable us to perform a wide range of analysis away from the stationary laboratory. Read More

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http://dx.doi.org/10.3390/polym12051154DOI Listing

Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications.

Int J Mol Sci 2020 May 18;21(10). Epub 2020 May 18.

Department of Ophthalmology and Eye Rehabilitation, Medical University of Bialystok, Kilinskiego 1, 15-089 Białystok, Poland.

The World Health Organization (WHO) has recognized obesity as one of the top ten threats to human health. It is estimated that the number of obese and overweight people worldwide exceeds the number of those who are undernourished. Obesity is not only a state of abnormally increased adipose tissue in the body, but also of increased release of biologically active adipokines. Read More

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http://dx.doi.org/10.3390/ijms21103570DOI Listing

Electrochemical ELISA Protein Biosensing in Undiluted Serum Using a Polypyrrole-Based Platform.

Sensors (Basel) 2020 May 18;20(10). Epub 2020 May 18.

Department of Electronic & Electrical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK.

An electrochemical enzyme-linked immunosorbent assay (ELISA) biosensor platform using electrochemically prepared ~11 nm thick carboxylic functionalized popypyrrole film has been developed for bio-analyte measurement in undiluted serum. Carboxyl polypyrrole (PPy-COOH) film using 3-carboxy-pyrrol monomer onto comb-shaped gold electrode microarray (Au) was prepared via cyclic voltammetry (CV). The prepared Au/PPy-COOH was then utilized for electrochemical ELISA platform development by immobilizing analyte-specific antibodies. Read More

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http://dx.doi.org/10.3390/s20102857DOI Listing

Controlling the Implementation of Transgenic Microbes: Are We Ready for What Synthetic Biology Has to Offer?

Mol Cell 2020 May;78(4):614-623

Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Warren Alpert 536, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, 5th Floor, Boston, MA 02115, USA. Electronic address:

Synthetic biology has promised and delivered on an impressive array of applications based on genetically modified microorganisms. While novel biotechnology undoubtedly offers benefits, like all new technology, precautions should be considered during implementation to reduce the risk of both known and unknown adverse effects. To achieve containment of transgenic microorganisms, confidence to a near-scientific certainty that they cannot transfer their transgenic genes to other organisms, and that they cannot survive to propagate in unintended environments, is a priority. Read More

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http://dx.doi.org/10.1016/j.molcel.2020.03.034DOI Listing

[Experimental study of the effectiveness of local anesthetic activity of a new dimethylphenylacetamide-containing pharmaceutical composition in chronic periodontitis].

Stomatologiia (Mosk) 2020 ;99(2):11-16

First Moscow State Medical University named after I.M. Sechenov (Sechenov University), Moscow, Russia.

Novel anaesthetic formulation LHT-15-32 was studied. The experimental study involved 66 white mice, 15 Rana radibunda frogs and 50 male Sprague Dawley rats. Its acute intravenous and subcutaneous toxicity was determined in mice. Read More

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http://dx.doi.org/10.17116/stomat20209902111DOI Listing