1,209 results match your criteria Biological research[Journal]


PELI3 mediates pro-tumor actions of down-regulated miR-365a-5p in non-small cell lung cancer.

Biol Res 2019 Apr 17;52(1):24. Epub 2019 Apr 17.

Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang, 050000, Hebei, China.

Background: To analyze the relative expression of PELI3 and its mechanistic involvement in the non-small cell lung cancer (NSCLC).

Methods: PELI3 expression in NSCLC tissue samples was determined by the immunohistochemistry. The transcripts abundance of PELI3 was measured with real-time PCR. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-019-0230-yDOI Listing
April 2019
1 Read

Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts.

Biol Res 2019 Apr 16;52(1):23. Epub 2019 Apr 16.

Department of Ophthalmology, The First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, 150001, Heilongjiang Province, People's Republic of China.

Background: Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodeling, fibrosis and tissue damage repairing. This study aimed to investigate the role of Cygb in anti-scarring during excessive conjunctival wound healing after glaucoma filtration surgery. Read More

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http://dx.doi.org/10.1186/s40659-019-0229-4DOI Listing

Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells.

Biol Res 2019 Apr 16;52(1):22. Epub 2019 Apr 16.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Tumor microenvironment (TME) plays a vital role in determining the outcomes of radiotherapy. As an important component of TME, vascular endothelial cells are involved in the perivascular resistance niche (PVRN), which is formed by inflammation or cytokine production induced by ionizing radiation (IR). Protein kinase CK2 is a constitutively active serine/threonine kinase which plays a vital role in cell proliferation and inflammation. Read More

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http://dx.doi.org/10.1186/s40659-019-0231-xDOI Listing

Methylation profile of the ADRB3 gene and its association with lipid profile and nutritional status in adults.

Biol Res 2019 Apr 6;52(1):21. Epub 2019 Apr 6.

Graduate Program in Nutrition, CCS, Federal University of Paraíba - UFPB), João Pessoa, Brazil.

Background: Defects in DNA methylation have been shown to be associated with metabolic diseases such as obesity, dyslipidemia, and hypercholesterolemia. To analyze the methylation profile of the ADRB3 gene and correlate it with lipid profile, lipid intake, and oxidative stress based on malondialdehyde (MDA) and total antioxidant capacity (TAC), homocysteine and folic acid levels, nutritional status, lifestyle, and socioeconomic variables in an adult population. A cross-sectional epidemiological study representative of the East and West regions of the municipality of João Pessoa, Paraíba state, Brazil, enrolled 265 adults of both genders. Read More

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http://dx.doi.org/10.1186/s40659-019-0226-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451774PMC
April 2019
1 Read

Molecular cloning and subcellular localization of six HDACs and their roles in response to salt and drought stress in kenaf (Hibiscus cannabinus L.).

Biol Res 2019 Apr 6;52(1):20. Epub 2019 Apr 6.

Key Laboratory of Plant Genetics and Breeding, College of Agriculture, Guangxi University, Nanning, 530005, People's Republic of China.

Background: Histone acetylation is an important epigenetic modification that regulates gene activity in response to stress. Histone acetylation levels are reversibly regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). The imperative roles of HDACs in gene transcription, transcriptional regulation, growth and responses to stressful environment have been widely investigated in Arabidopsis. Read More

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http://dx.doi.org/10.1186/s40659-019-0227-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451785PMC
April 2019
1 Read
1.480 Impact Factor

Identification and characterization of CircRNAs involved in the regulation of wheat root length.

Biol Res 2019 Apr 4;52(1):19. Epub 2019 Apr 4.

College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.

Background: Recent studies indicate that circular RNAs (circRNAs) may play important roles in the regulation of plant growth and development. Plant roots are the main organs of nutrient and water uptake. However, whether circRNAs involved in the regulation of plant root growth remains to be elucidated. Read More

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http://dx.doi.org/10.1186/s40659-019-0228-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448277PMC

MicroRNA-663 facilitates the growth, migration and invasion of ovarian cancer cell by inhibiting TUSC2.

Biol Res 2019 Apr 3;52(1):18. Epub 2019 Apr 3.

Department of Gynaecology, the 2nd Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Background: MicroRNAs (miRNAs) have emerged as the critical modulators of the tumorigenesis and tumor progression.

Methods: The levels of miR-663 in ovarian cancer cell lines and clinical tissues were detected using qRT-PCR assays. The Transwell invasion and wound healing assay were conducted to assess the roles of miR-663 in the migration and invasion of ovarian cancer cell in vitro. Read More

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http://dx.doi.org/10.1186/s40659-019-0219-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448305PMC
April 2019
4 Reads

Plant morphology, physiological characteristics, accumulation of secondary metabolites and antioxidant activities of Prunella vulgaris L. under UV solar exclusion.

Biol Res 2019 Apr 1;52(1):17. Epub 2019 Apr 1.

Rice Research Institute, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.

Background: Prunella vulgaris L. has been an important medicinal plant for the treatment of thyroid gland malfunction and mastitis in China for over 2000 years. There is an urgent need to select effective wavelengths for greenhouse cultivation of P. Read More

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http://dx.doi.org/10.1186/s40659-019-0225-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442409PMC

Effects of glutamine deprivation on oxidative stress and cell survival in breast cell lines.

Biol Res 2019 Mar 27;52(1):15. Epub 2019 Mar 27.

Department of Physiology, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Arcadia, Pretoria, 0007, South Africa.

Background: Tumourigenic cells modify metabolic pathways in order to facilitate increased proliferation and cell survival resulting in glucose- and glutamine addiction. Previous research indicated that glutamine deprivation resulted in potential differential activity targeting tumourigenic cells more prominently. This is ascribed to tumourigenic cells utilising increased glutamine quantities for enhanced glycolysis- and glutaminolysis. Read More

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http://dx.doi.org/10.1186/s40659-019-0224-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437944PMC

In vitro transplantation of spermatogonial stem cells isolated from human frozen-thawed testis tissue can induce spermatogenesis under 3-dimensional tissue culture conditions.

Biol Res 2019 Mar 27;52(1):16. Epub 2019 Mar 27.

Department of Andrology and Embryology, Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.

Background: Sperm production is one of the most complex biological processes in the body. In vitro production of sperm is one of the most important goals of researches in the field of male infertility treatment, which is very important in male cancer patients treated with gonadotoxic methods and drugs. In this study, we examine the progression of spermatogenesis after transplantation of spermatogonial stem cells under conditions of testicular tissue culture. Read More

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http://dx.doi.org/10.1186/s40659-019-0223-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438003PMC
March 2019
1 Read

Knock-down the expression of TaH2B-7D using virus-induced gene silencing reduces wheat drought tolerance.

Biol Res 2019 Mar 21;52(1):14. Epub 2019 Mar 21.

College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.

Background: Drought is a major abiotic stress affecting global wheat (Triticum aestivum L.) production. Exploration of drought-tolerant genes is essential for the genetic improvement of drought tolerance in wheat. Read More

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http://dx.doi.org/10.1186/s40659-019-0222-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427858PMC
March 2019
1 Read

Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line.

Biol Res 2019 Mar 21;52(1):13. Epub 2019 Mar 21.

Laboratorio de Patología Molecular, Centro de Excelencia en Medicina Traslacional-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Avenida Alemania #0478, 3th Floor, Temuco, Chile.

Background: Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. Read More

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http://dx.doi.org/10.1186/s40659-019-0220-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427839PMC
March 2019
1 Read

CoCl simulated hypoxia induce cell proliferation and alter the expression pattern of hypoxia associated genes involved in angiogenesis and apoptosis.

Biol Res 2019 Mar 15;52(1):12. Epub 2019 Mar 15.

Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, U. P., 221005, India.

Background/aims: Hypoxia microenvironment plays a crucial role during tumor progression and it tends to exhibit poor prognosis and make resistant to various conventional therapies. HIF-1α acts as an important transcriptional regulator directly or indirectly associated with genes involved in cell proliferation, angiogenesis, apoptosis and energy metabolism during tumor progression in hypoxic microenvironment. This study was aimed to investigate the expression pattern of the hypoxia associated genes and their association during breast cancer progression under hypoxic microenvironment in breast cancer cells. Read More

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http://dx.doi.org/10.1186/s40659-019-0221-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419504PMC
March 2019
1.480 Impact Factor

IRF2-INPP4B-mediated autophagy suppresses apoptosis in acute myeloid leukemia cells.

Biol Res 2019 Mar 15;52(1):11. Epub 2019 Mar 15.

Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, No. 287 Changhuai Road, Bengbu, 233004, Anhui, People's Republic of China.

Background: The present study aimed to investigate the underlying role of interferon-regulatory factor 2 (IRF2)-inositol polyphosphate-4-phosphatase, type-II (INPP4B) axis in the regulation of autophagy in acute myeloid leukemia (AML) cells.

Methods: Quantitative real time PCR (QRT-PCR) and western blot were performed to determine the expression levels of IRF2, INPP4B and autophagy-related markers in AML cell lines. Autophagy was assessed by elevated Beclin-1 expression, the conversion of light chain 3 (LC3)-I to LC3-II, downregulated p62 expression and green fluorescent protein (GFP)-LC3 puncta formation. Read More

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http://dx.doi.org/10.1186/s40659-019-0218-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419480PMC
March 2019
3 Reads

Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways.

Biol Res 2019 Mar 13;52(1):10. Epub 2019 Mar 13.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.

Background: Non-canonical Wnt pathways play important roles in liver fibrosis. Notum is a newly discovered inhibitor to Wnt proteins. This study was to investigate anti-fibrotic effects of Notum. Read More

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http://dx.doi.org/10.1186/s40659-019-0217-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419342PMC
March 2019
2 Reads

Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice.

Biol Res 2019 Mar 1;52(1). Epub 2019 Mar 1.

Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, 571199, China.

Background: Fava beans (FBs) have long been used as food, and their principal disadvantage is derived from their haemotoxicity. We hypothesized that FB ingestion alters the intestinal gene expression pattern, thereby inducing an immune response.

Results: In-depth sequence analysis identified 769 differentially expressed genes (DEGs) associated with the intestine in FB-treated DBA/1 mouse intestines. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-019-0216-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396536PMC
March 2019
7 Reads

Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway.

Biol Res 2019 Feb 27;52(1). Epub 2019 Feb 27.

Department of Gynecologic Oncology, Shandong Tumor Hospital and Institute, No. 440, Yan Ji Road, Jinan, 250117, Shandong, China.

Background: Cervical cancer (CC) ranks third in the morbidity and mortality of female cancer around the world. Derlin1 has been found to be overexpressed in several human cancers. However, it is still unclear about its roles in CC. Read More

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http://dx.doi.org/10.1186/s40659-019-0215-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391802PMC
February 2019
1 Read
1.480 Impact Factor

Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells.

Biol Res 2019 Feb 23;52(1). Epub 2019 Feb 23.

Department of Integrated Chinese and Western Medicine, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, No. 127 Dongming Road, Zhengzhou City, 450008, Henan Province, People's Republic of China.

Background: Currently, the prognosis of patients with non-small cell lung cancer (NSCLC) remains dismal; hence, it is critical to identify effective anti-NSCLC agents with limited side effects. This study aimed to evaluate the therapeutic potential of flavonoid compound vitexin in human NSCLC cells and the underlying mechanisms.

Results: The experimental results indicated that vitexin reduced the viability of A549 cells in a dose-dependent manner with nearly no toxicity against normal human bronchial epithelial 16HBE cells. Read More

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http://dx.doi.org/10.1186/s40659-019-0214-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387544PMC
February 2019
1 Read

RNA editing analysis of ATP synthase genes in the cotton cytoplasmic male sterile line H276A.

Biol Res 2019 Feb 6;52(1). Epub 2019 Feb 6.

Key Laboratory of Plant Genetic and Breeding, College of Agriculture, Guangxi University, Nanning, 530005, People's Republic of China.

Background: Pollen development is an energy-consuming process that particularly occurs during meiosis. Low levels of adenosine triphosphate (ATP) may cause cell death, resulting in CMS (cytoplasmic male sterility). DNA sequence differences in ATP synthase genes have been revealed between the N- and S-cytoplasms in the cotton CMS system. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-019-0212-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364438PMC
February 2019
11 Reads

Identification of the targets of hematoporphyrin derivative in lung adenocarcinoma using integrated network analysis.

Authors:
Hongtao Yin Yan Yu

Biol Res 2019 Feb 4;52(1). Epub 2019 Feb 4.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin, 150081, Heilongjiang, China.

Background: Hematoporphyrin derivative (HPD) has a sensibilization effect in lung adenocarcinoma. This study was conducted to identify the target genes of HPD in lung adenocarcinoma.

Methods: RNA sequencing was performed using the lung adenocarcinoma cell line A549 after no treatment or treatment with X-ray or X-ray + HPD. Read More

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http://dx.doi.org/10.1186/s40659-019-0213-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360726PMC
February 2019
4 Reads

Isolation and partial characterization of a new moderate thermophilic Albidovulum sp. SLM16 with transaminase activity from Deception Island, Antarctica.

Biol Res 2019 Feb 4;52(1). Epub 2019 Feb 4.

Fundación Científica y Cultural Biociencia, José Domingo Cañas 2280, Santiago, Chile.

Background: A moderately thermophilic, slightly halophilic, aerobic, Gram-stain negative, bacterial strain, SLM16, was isolated from a mixed of seawater-sand-sediment sample collected from a coastal fumarole located in Whalers Bay, Deception Island, Antarctica. The aim was to screen for thermophilic microorganisms able to degrade primary amines and search for amine transaminase activity for potential industrial application.

Results: Identification and partial characterization of the microorganism SLM16 were carried out by means of morphological, physiological and biochemical tests along with molecular methods. Read More

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http://dx.doi.org/10.1186/s40659-018-0210-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360757PMC
February 2019

De novo in vitro shoot morphogenesis from shoot tip-induced callus cultures of Gymnema sylvestre (Retz.) R.Br. ex Sm.

Authors:
Tasiu Isah

Biol Res 2019 Jan 19;52(1). Epub 2019 Jan 19.

Department of Botany, School of Chemical and Life Sciences, Hamdard University, New Delhi, 110 062, India.

Background: Gymnema sylvestre is a medicinal woody perennial vine known for its sweetening properties and anti-diabetic therapeutic uses in the modern and traditional medicines. Its over-exploitation for the therapeutic uses and to meet the demand of pharmaceutical industry in raw materials supply for the production of anti-diabetic drugs has led to considerable decline in its natural population.

Results: An efficient system of shoot bud sprouting from nodal segment explants and indirect plant regeneration from apical meristem-induced callus cultures of G. Read More

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http://dx.doi.org/10.1186/s40659-019-0211-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339694PMC
January 2019
1 Read
1.480 Impact Factor

ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer.

Biol Res 2019 Jan 8;52(1). Epub 2019 Jan 8.

Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separately in gastric cancer, there is not any report about the probable correlation between ErbB1 and ErbB3 co-expression and gastric cancer prognosis. In present study, we assessed the correlation between ErbB1 and ErbB3 co-overexpression (in the level of mRNA and protein expression) and gastric cancer prognosis for the first time. Read More

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http://dx.doi.org/10.1186/s40659-018-0208-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323733PMC
January 2019
1 Read

Isolation of dihydrobenzofuran derivatives from ethnomedicinal species Polygonum barbatum as anticancer compounds.

Biol Res 2019 Jan 7;52(1). Epub 2019 Jan 7.

Department of Pharmacy, University of Malakand, Dir (L), Chakdara, 18000, KP, Pakistan.

Background: Ethnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of this family have been reported with anticancer potentials. This study was designed to isolate anticancer compounds from ethnomedicinally important species Polygonum barbatum. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0209-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322347PMC
January 2019
12 Reads

Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling.

Biol Res 2018 Dec 29;51(1):58. Epub 2018 Dec 29.

Reproductive Medical Center, Department of Gynecology and Obstetrics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Studies have demonstrated that transforming growth factor beta-1 (TGF-β1) exhibits oncogenic activity in different types of cancer, including ovarian cancer (OC). However, its regulatory mechanism in OC and whether TGF-β1 is involved in chemosensitivity regulation remains unclear. Thus, the aim of this study was to investigate the role of TGF-β1 in OC. Read More

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http://dx.doi.org/10.1186/s40659-018-0205-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310971PMC
December 2018
2 Reads

Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits.

Biol Res 2018 Dec 20;51(1):57. Epub 2018 Dec 20.

Laboratorio de Neurobiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it's impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial blood pressure, heart rate and heart rate variability (HRV) in rabbits subjected to chronic normobaric hypoxia (CNH; PB ~ 719 mmHg; FO ~ 9.2%) for 14 days and assess the effect of autonomic control by acute bilateral vagal denervation. Read More

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http://dx.doi.org/10.1186/s40659-018-0207-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300919PMC
December 2018
1 Read
1.480 Impact Factor

MicroRNA-153-3p enhances cell radiosensitivity by targeting BCL2 in human glioma.

Biol Res 2018 Dec 11;51(1):56. Epub 2018 Dec 11.

Department of Neurosurgery, Liaoning Cancer Hospital & Institute, No.44 Xiao Heyan Street, Shenyang, 110042, Liaoning, China.

Background: Glioma is the most prevalent malignant tumor in human central nervous systems. Recently, the development of resistance to radiotherapy in glioma patients markedly vitiates the therapy outcome. MiR-153-3p has been reported to be closely correlated with tumor progression, but its effect and molecular mechanism underlying radioresistance remains unclear in glioma. Read More

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http://dx.doi.org/10.1186/s40659-018-0203-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288870PMC
December 2018
1 Read

A thermophilic microorganism from Deception Island, Antarctica with a thermostable glutamate dehydrogenase activity.

Biol Res 2018 Dec 8;51(1):55. Epub 2018 Dec 8.

Fundación Científica y Cultural Biociencia, José Domingo Cañas 2280, Santiago, 7750132, Chile.

Background: The Antarctic continent is a source of extreme microorganisms. Millions of years of isolation have produced unique biodiversity with adaptive responses to its extreme environment. Although the Antarctic climate is mainly cold, the presence of several geothermal sites, including thermal springs, fumaroles, hot soils and hydrothermal vents, provides ideal environments for the development of thermophilic and hyperthermophilic microorganisms. Read More

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http://dx.doi.org/10.1186/s40659-018-0206-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286571PMC
December 2018
2 Reads

The deubiquitinase USP38 affects cellular functions through interacting with LSD1.

Biol Res 2018 Nov 29;51(1):53. Epub 2018 Nov 29.

College of Health Sciences and Nursing, Wuhan Polytechnic University, No. 68 Southern Xuefu Road, Wuhan, 430023, Hubei, China.

Background: Deubiquitination is a posttranslational protein modification prevalent in mammalian cells. Deubiquitinases regulate the functions of the target protein by removing its ubiquitin chain. In this study, the effects of the deubiquitinase USP38's functions on the LSD1 protein and on cell physiology were investigated. Read More

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http://dx.doi.org/10.1186/s40659-018-0201-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263071PMC
November 2018
2 Reads
1.480 Impact Factor

Effect of urea-extracted sericin on melanogenesis: potential applications in post-inflammatory hyperpigmentation.

Biol Res 2018 Nov 29;51(1):54. Epub 2018 Nov 29.

Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Ratchawithi Road, Ratchathewi, Bangkok, 10400, Thailand.

Background: Hyperpigmentation disorders such as post-inflammatory hyperpigmentation are major concerns not only in light-skinned people but also in Asian populations with darker skin. The anti-tyrosinase and immunomodulatory effects of sericin have been known for decades. However, the therapeutic effects of sericin on hyperpigmentation disorders have not been well documented. Read More

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http://dx.doi.org/10.1186/s40659-018-0204-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262948PMC
November 2018
11 Reads

Overexpression of PIK3R1 promotes hepatocellular carcinoma progression.

Biol Res 2018 Nov 29;51(1):52. Epub 2018 Nov 29.

The Key Laboratory of Medical Molecular Biology, Guizhou Medical University, Guiyang, 550002, China.

Background: Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could regulate cancer cell proliferation important for cancer cell proliferation; however, its role in Hepatocellular carcinoma (HCC) remains largely unknown. Here, we investigated the role of PIK3R1 in HCC and examined the underlying molecular mechanisms.

Methods: The expression of PIK3R1 was evaluated by immunohistochemistry and qRT-PCR in a series of HCC tissues. Read More

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http://dx.doi.org/10.1186/s40659-018-0202-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264640PMC
November 2018
11 Reads

MiR-219-5p inhibits growth and metastasis of ovarian cancer cells by targeting HMGA2.

Biol Res 2018 Nov 24;51(1):50. Epub 2018 Nov 24.

Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, No 301 Middle Yan Chang Road, Shanghai, 200072, China.

Background: Accumulating studies have demonstrated that high-mobility group A2 (HMGA2), an oncofetal protein, plays a role in tumor development and progression. However, the molecular role of HMGA2 in ovarian carcinoma is yet to be established. MicroRNAs (miRNAs), a group of small noncoding RNAs, negatively regulate gene expression and their dysregulation has been implicated in tumorigenesis. Read More

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http://dx.doi.org/10.1186/s40659-018-0199-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260846PMC
November 2018
4 Reads

MicroRNA-382 inhibits cell growth and migration in colorectal cancer by targeting SP1.

Biol Res 2018 Nov 24;51(1):51. Epub 2018 Nov 24.

Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, NO.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, People's Republic of China.

Background: Emerging evidence showed that microRNAs (miRs) play critical roles in human cancers by functioning as either tumor suppressor or oncogene. MIR-382 was found to function as tumor suppressor in certain cancers. However, the role of MIR-382 in colorectal cancer (CRC) is largely unknown. Read More

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http://dx.doi.org/10.1186/s40659-018-0200-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260849PMC
November 2018
2 Reads

Photoprotection enhanced by red cell wall pigments in three East Antarctic mosses.

Biol Res 2018 Nov 21;51(1):49. Epub 2018 Nov 21.

Centre for Sustainable Ecosystem Solutions, School of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia.

Background: Antarctic bryophytes (mosses and liverworts) are resilient to physiologically extreme environmental conditions including elevated levels of ultraviolet (UV) radiation due to depletion of stratospheric ozone. Many Antarctic bryophytes synthesise UV-B-absorbing compounds (UVAC) that are localised in their cells and cell walls, a location that is rarely investigated for UVAC in plants. This study compares the concentrations and localisation of intracellular and cell wall UVAC in Antarctic Ceratodon purpureus, Bryum pseudotriquetrum and Schistidium antarctici from the Windmill Islands, East Antarctica. Read More

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http://dx.doi.org/10.1186/s40659-018-0196-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247747PMC
November 2018
14 Reads

Coping with drought: stress and adaptive mechanisms, and management through cultural and molecular alternatives in cotton as vital constituents for plant stress resilience and fitness.

Biol Res 2018 Nov 14;51(1):47. Epub 2018 Nov 14.

The Key Laboratory of Oasis Eco-agriculture, Xinjiang Production and Construction Group, Shihezi University, Shihezi, 832003, People's Republic of China.

Increased levels of greenhouse gases in the atmosphere and associated climatic variability is primarily responsible for inducing heat waves, flooding and drought stress. Among these, water scarcity is a major limitation to crop productivity. Water stress can severely reduce crop yield and both the severity and duration of the stress are critical. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0198-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234603PMC
November 2018
23 Reads
1.480 Impact Factor

Copper stress induces antioxidant responses and accumulation of sugars and phytochelatins in Antarctic Colobanthus quitensis (Kunth) Bartl.

Biol Res 2018 Nov 14;51(1):48. Epub 2018 Nov 14.

Laboratorio de Fisiología y Biotecnología Vegetal, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, L.B. O'Higgins #3363, Estación Central, Santiago, Chile.

Background: In field, C. quitensis is subjected to many abiotic extreme environmental conditions, such as low temperatures, high UV-B, salinity and reduced water potentials, but not metal or metalloid high concentrations in soil, however, other members of Caryophyllaceae family have tolerance to high concentrations of metals, this is the case of Silene genre. In this work, we hypothesize that C. Read More

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http://dx.doi.org/10.1186/s40659-018-0197-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234666PMC
November 2018
10 Reads

The physiological and molecular mechanism of brassinosteroid in response to stress: a review.

Biol Res 2018 Nov 12;51(1):46. Epub 2018 Nov 12.

The Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

The negative effects of environmental stresses, such as low temperature, high temperature, salinity, drought, heavy metal stress, and biotic stress significantly decrease crop productivity. Plant hormones are currently being used to induce stress tolerance in a variety of plants. Brassinosteroids (commonly known as BR) are a group of phytohormones that regulate a wide range of biological processes that lead to tolerance of various stresses in plants. Read More

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http://dx.doi.org/10.1186/s40659-018-0195-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231256PMC
November 2018
25 Reads

Identification of key genes and miRNAs markers of papillary thyroid cancer.

Biol Res 2018 Nov 10;51(1):45. Epub 2018 Nov 10.

Otolaryngology Head and Neck Surgery, Qingdao Municipal Hospital, No. 5 Donghai Road, Qingdao, 266071, Shandong, China.

Objective: In this study, crucial genes and microRNAs (miRNAs) associated with the progression, staging, and prognosis of papillary thyroid cancer (PTC) were identified.

Methods: Four PTC datasets, including our own mRNA-sequencing (mRNA-seq) dataset and three public datasets downloaded from Gene Expression Omnibus and The Cancer Genome Atlas, were used to analyze differentially expressed genes (DEGs) and miRNAs (DEMs) between PTC tumor tissues and paired normal tissues (control). Gene ontology (GO) terms and pathways associated with these DEGs were identified, and protein-protein interactions (PPIs) were analyzed. Read More

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http://dx.doi.org/10.1186/s40659-018-0188-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230289PMC
November 2018
18 Reads

Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer.

Biol Res 2018 Nov 3;51(1):44. Epub 2018 Nov 3.

Department of Gastrointestinal and Colorectal Surgery, China-Japan Union Hospital, Jilin University, No.126, Xiantai Street, Changchun, 130033, China.

Background: Emerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the molecular mechanisms of GC by comprehensive analysis of mRNAs and miRNA expression profiles.

Methods: The mRNA and miRNA expression profiles of GSE79973 and GSE67354 downloaded from Gene Expression Omnibus were used to analyze the differentially expressed genes (DEGs) and DE-miRNAs among GC tissues and normal tissues. Read More

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http://dx.doi.org/10.1186/s40659-018-0192-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215350PMC
November 2018
2 Reads

Identification and characterization of circRNAs involved in the regulation of low nitrogen-promoted root growth in hexaploid wheat.

Biol Res 2018 Nov 3;51(1):43. Epub 2018 Nov 3.

College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.

Background: CircRNAs are widespread in plants and play important roles in response to abiotic stresses. Low nitrogen (LN) promotes the growth of plant root system, allowing it to explore more nitrogen. However, whether circRNAs involved in the response to LN stress and the regulation of LN-promoted root growth in wheat remains unclear. Read More

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http://dx.doi.org/10.1186/s40659-018-0194-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215338PMC
November 2018
15 Reads

Priming stem cells with protein kinase C activator enhances early stem cell-chondrocyte interaction by increasing adhesion molecules.

Biol Res 2018 Nov 1;51(1):41. Epub 2018 Nov 1.

Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea.

Background: Osteoarthritis (OA) can be defined as degradation of articular cartilage of the joint, and is the most common degenerative disease. To regenerate the damaged cartilage, different experimental approaches including stem cell therapy have been tried. One of the major limitations of stem cell therapy is the poor post-transplantation survival of the stem cells. Read More

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http://dx.doi.org/10.1186/s40659-018-0191-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211543PMC
November 2018
2 Reads

Development and characterization of microsatellite markers in Gaultheria pumila Lf. (Ericaceae).

Biol Res 2018 Nov 1;51(1):42. Epub 2018 Nov 1.

Verdant BioScience Pte. Ltda, 18, Duxton Hill, Singapore, 089601, Singapore.

Background: Polymorphic microsatellite markers were developed for Gaultheria pumila (Ericaceae) to evaluate genetic diversity and population structure within its native range in Chile. This is a very important Ericaceae endemic to Chile with a large commercial potential. Its resistance to different abiotic conditions makes it a valuable target for genetic improvement. Read More

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http://dx.doi.org/10.1186/s40659-018-0193-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211410PMC
November 2018
15 Reads

High-throughput micro-phenotyping measurements applied to assess stalk lodging in maize (Zea mays L.).

Biol Res 2018 Oct 27;51(1):40. Epub 2018 Oct 27.

Beijing Key Lab of Digital Plant, Beijing Research Center for Information Technology in Agriculture, Beijing Academy of Agriculture and Forestry Sciences, Shuguang Huayuan Middle Road, Haidian District, No. 11, Beijing, 100097, People's Republic of China.

Background: The biomechanical properties of maize stalks largely determine their lodging resistance, which affects crop yield per unit area. However, the quantitative and qualitative relationship between micro-phenotypes and the biomechanics of maize stalks is still under examined. In particular, the roles of the number, geometry, and distribution of vascular bundles of stalks in maize lodging resistance remain unclear. Read More

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http://dx.doi.org/10.1186/s40659-018-0190-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203980PMC
October 2018
16 Reads

Knockdown of SETDB1 inhibits breast cancer progression by miR-381-3p-related regulation.

Biol Res 2018 Oct 11;51(1):39. Epub 2018 Oct 11.

Department of Oncology, The Affiliated Hospital of Qinghai University, No. 29, Tongren Rd, Xining, 810001, Qinghai, China.

Background: SET domain bifurcated 1 (SETDB1) has been widely considered as an oncogene playing a critical role in many human cancers, including breast cancer. Nevertheless, the molecular mechanism by which SETDB1 regulates breast cancer tumorigenesis is still unknown.

Methods: qRT-PCR assay or western blot analysis was performed to assess the expression level of SETDB1 mRNA or protein, respectively. Read More

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http://dx.doi.org/10.1186/s40659-018-0189-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180515PMC
October 2018
2 Reads
1.480 Impact Factor

ADAR1-mediated RNA-editing of 3'UTRs in breast cancer.

Biol Res 2018 Oct 5;51(1):36. Epub 2018 Oct 5.

Center of Excellence in Precision Medicine, Pfizer Chile, Obispo Arturo Espinoza Campos 2526, 7810305, Santiago, Chile.

Background: Whole transcriptome RNA variant analyses have shown that adenosine deaminases acting on RNA (ADAR) enzymes modify a large proportion of cellular RNAs, contributing to transcriptome diversity and cancer evolution. Despite the advances in the understanding of ADAR function in breast cancer, ADAR RNA editing functional consequences are not fully addressed.

Results: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. Read More

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http://dx.doi.org/10.1186/s40659-018-0185-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172785PMC
October 2018
4 Reads

Biotechnological applications of archaeal enzymes from extreme environments.

Biol Res 2018 Oct 5;51(1):37. Epub 2018 Oct 5.

Fundación Científica y Cultural Biociencia, José Domingo Cañas, 2280, Santiago, Chile.

To date, many industrial processes are performed using chemical compounds, which are harmful to nature. An alternative to overcome this problem is biocatalysis, which uses whole cells or enzymes to carry out chemical reactions in an environmentally friendly manner. Enzymes can be used as biocatalyst in food and feed, pharmaceutical, textile, detergent and beverage industries, among others. Read More

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http://dx.doi.org/10.1186/s40659-018-0186-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172850PMC
October 2018
2 Reads

Involvement of K and Ca channels in hydrogen sulfide-suppressed ageing of porcine oocytes.

Biol Res 2018 Oct 5;51(1):38. Epub 2018 Oct 5.

Institute of Animal Science, Uhrineves, Prague 10, Czech Republic.

Background: Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydrogen sulfide in gametes and embryos remains unknown. Our observations confirmed the hypothesis that the K and L-type Ca ion channels play roles in porcine oocyte ageing and revealed a plausible contribution of hydrogen sulfide to the modulation of ion channel activity. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0187-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172760PMC
October 2018
24 Reads

Thiamine deficiency contributes to synapse and neural circuit defects.

Biol Res 2018 Sep 19;51(1):35. Epub 2018 Sep 19.

Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Background: The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer's disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitive impairment. The reduction of thiamine diphosphate may contribute to the dysfunction of synapses and neural circuits, finally leading to cognitive decline.

Results: To demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density. Read More

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http://dx.doi.org/10.1186/s40659-018-0184-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145320PMC
September 2018
4 Reads

Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice.

Biol Res 2018 Sep 15;51(1):34. Epub 2018 Sep 15.

Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay #362 - 4º, Piso, 8330024, Santiago, Chile.

Background And Aims: Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been proposed as atheroprotective agents for cardiovascular disease management. However, their effects and benefits on high density lipoprotein function and remodeling are unknown. Read More

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http://dx.doi.org/10.1186/s40659-018-0183-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138920PMC
September 2018
3 Reads

Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis.

Biol Res 2018 Sep 5;51(1):33. Epub 2018 Sep 5.

Laboratory of Translational Physiology, Health Sciences Center, Federal University of Espirito Santo (UFES), Vitoria, Brazil.

Background: New evidence demonstrates that aging and dyslipidemia are closely associated with oxidative stress, DNA damage and apoptosis in some cells and extravascular tissues. However, in monocytes, which are naturally involved in progression and/or resolution of plaque in atherosclerosis, this concurrence has not yet been fully investigated. In this study, we evaluated the influence of aging and hypercholesterolemia on serum pro-inflammatory cytokines, oxidative stress, DNA damage and apoptosis in monocytes from apolipoprotein E-deficient (apoE) mice compared with age-matched wild-type C57BL/6 (WT) mice. Read More

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http://dx.doi.org/10.1186/s40659-018-0182-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123971PMC
September 2018
2 Reads