1,268 results match your criteria Biological research[Journal]


Genome-wide characterization of the abscisic acid-, stress- and ripening-induced (ASR) gene family in wheat (Triticum aestivum L.).

Biol Res 2020 May 24;53(1):23. Epub 2020 May 24.

Jinan Yongfeng Seed Industry Co., Ltd, 3620 Pingannan Road, Jinan, 250100, China.

Background: Abscisic acid-, stress-, and ripening-induced (ASR) genes are a class of plant specific transcription factors (TFs), which play important roles in plant development, growth and abiotic stress responses. The wheat ASRs have not been described in genome-wide yet.

Methods: We predicted the transmembrane regions and subcellular localization using the TMHMM server, and Plant-mPLoc server and CELLO v2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00291-6DOI Listing

Engraftment of human induced pluripotent stem cell-derived myogenic progenitors restores dystrophin in mice with duchenne muscular dystrophy.

Biol Res 2020 May 19;53(1):22. Epub 2020 May 19.

Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: Duchenne muscular dystrophy (DMD) is a devastating genetic muscular disorder with no effective treatment that is caused by the loss of dystrophin. Human induced pluripotent stem cells (hiPSCs) offer a promising unlimited resource for cell-based therapies of muscular dystrophy. However, their clinical applications are hindered by inefficient myogenic differentiation, and moreover, the engraftment of non-transgene hiPSC-derived myogenic progenitors has not been examined in the mdx mouse model of DMD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00288-1DOI Listing

Development of nuclear SSR and chloroplast genome markers in diverse Liriodendron chinense germplasm based on low-coverage whole genome sequencing.

Biol Res 2020 May 14;53(1):21. Epub 2020 May 14.

State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, China.

Background: Liriodendron chinense ranges widely in subtropical China and northern Vietnam; however, it inhabits several small, isolated populations and is now an endangered species due to its limited seed production. The objective of this study was to develop a set of nuclear SSR (simple sequence repeats) and multiple chloroplast genome markers for genetic studies in L. chinense and their characterization in diverse germplasm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00289-0DOI Listing

Analysis of the role of the interleukins in colon cancer.

Biol Res 2020 May 7;53(1):20. Epub 2020 May 7.

Department of General Surgery, Shanghai Pudong Hospita, Fudan University Pudong Medical Center, 2800 Gongwei Road, Huinan Town, Pudong, 201399, Shanghai, China.

Background: The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients.

Methods: A total of 15 differentially expressed interleukins between the colon cancer tissue and normal colon tissue were evaluated from the Cancer Genome Atlas (TCGA) database with R software and only interleukin-7 (IL-7) was significantly associated with survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00287-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203842PMC
May 2020
1.480 Impact Factor

miR-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting Bcl2.

Biol Res 2020 May 4;53(1):19. Epub 2020 May 4.

Biotechnology Institute, Ankara University, Keçiören, 06135, Ankara, Turkey.

Background: Breast cancer is the most common cancer types among women. Recent researches have focused on determining the efficiency of alternative molecules and miRNAs in breast cancer treatment. The aim of this study was to determine the effect of usnic acid response-miR-185-5p on proliferation in the breast cancer cell and to determine its relationship with apoptosis pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00285-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197166PMC

Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1.

Biol Res 2020 Apr 29;53(1):18. Epub 2020 Apr 29.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinzhou Medical University, No. 2, Section 5, Renmin Street, Jinzhou, 121001, Liaoning, People's Republic of China.

Background: Cisplatin resistance (DDP-resistance) remains one of the major causes of poor prognosis in females with ovarian cancer. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of cellular processes, including chemoresistance. The aim of this study was to explore the role of HOX transcript antisense RNA (HOTAIR) in DDP-resistant ovarian cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00286-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191713PMC

Inhibition of miR-19a-3p decreases cerebral ischemia/reperfusion injury by targeting IGFBP3 in vivo and in vitro.

Biol Res 2020 Apr 20;53(1):17. Epub 2020 Apr 20.

Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310003, China.

Background: Inflammation and apoptosis are considered to be two main factors affecting ischemic brain injury and the subsequent reperfusion damage. MiR-19a-3p has been reported to be a possible novel biomarker in ischemic stroke. However, the function and molecular mechanisms of miR-19a-3p remain unclear in cerebral ischemia/reperfusion (I/R) injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00280-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171820PMC

Correction to: Identification of the targets of hematoporphyrin derivative in lung adenocarcinoma using integrated network analysis.

Authors:
Hongtao Yin Yan Yu

Biol Res 2020 Apr 19;53(1):16. Epub 2020 Apr 19.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin, 150081, Heilongjiang, China.

The Fig. 1b is wrongly published in the original publication of the article. The correct version of Fig. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00281-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168872PMC

Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.

Biol Res 2020 Apr 15;53(1):13. Epub 2020 Apr 15.

Department of Pathology, Faculty of Medicine, Millennium Institute of Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Gallbladder cancer (GBC) is the most common tumor of the biliary tract. The incidence of GBC shows a large geographic variability, being particularly frequent in Native American populations. In Chile, GBC represents the second cause of cancer-related death among women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00282-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158131PMC

LncRNA LINC00483 promotes gastric cancer development through regulating MAPK1 expression by sponging miR-490-3p.

Biol Res 2020 Apr 15;53(1):14. Epub 2020 Apr 15.

Departments of Gastroenterology, The Second Xiangya Hospital of Central South University, No. 139 RenMin Road, Changsha, 410011, Hunan, China.

Background: Previous studies have shown that long noncoding RNA (lncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this lncRNA in gastric cancer remains largely unknown. The present study aimed to investigate the effect of LINC00483 on gastric cancer development and explore the potential regulatory network of LINC00483/microRNA (miR)-490-3p/mitogen-activated protein kinase 1 (MAPK1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00283-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158027PMC

Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells.

Biol Res 2020 Mar 24;53(1):12. Epub 2020 Mar 24.

Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.

Background: Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. However, the function of MCs in IBD remains to be fully elucidated.

Results: In our study, we used exosomes isolated from human mast cells-1 (HMCs-1) to culture with NCM460, HT-29 or CaCO2 of intestinal epithelial cells (IECs) to investigate the communication between MCs and IECs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00279-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092522PMC
March 2020
1.480 Impact Factor

MicroRNA-107 is a novel tumor suppressor targeting POU3F2 in melanoma.

Biol Res 2020 Mar 14;53(1):11. Epub 2020 Mar 14.

Department of Dermatology, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, No. 5 Shipping Warehouse, Dongcheng District, Beijing, 100700, China.

Background: Melanoma is one of the major types of skin cancer. The metastatic melanoma is among the most lethal forms of malignant skin tumors. We hereby aimed to characterize a novel microRNA (miR) in the metastatic melanoma model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00278-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071777PMC

Mir-30b-3p affects the migration and invasion function of ovarian cancer cells by targeting the CTHRC1 gene.

Biol Res 2020 Mar 10;53(1):10. Epub 2020 Mar 10.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, 215006, Jiangsu, People's Republic of China.

Background: The aim of this study was to investigate the effect role and mechanism of miR-30b-3p on ovarian cancer cells biological function.

Methods: The expression of miR-30b-3p was detected in ovarian cancer cell lines and normal ovarian epithelial cell line by qRT-PCR. Mir-30b-3p mimic was transfected into OVCAR3 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00277-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063805PMC
March 2020
1.480 Impact Factor

Studies on the cold tolerance of ratoon 'Chaling' common wild rice.

Biol Res 2020 Feb 18;53(1). Epub 2020 Feb 18.

State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, 430072, China.

Background: Rice is the staple food of many people around the world. However, most rice varieties, especially widely grown indica varieties and hybrids, are sensitive to cold stress. In order to provide a basis for the utilization of a common wild rice (CWR, Oryza rufipogon Griff. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00276-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027047PMC
February 2020

LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthritis.

Biol Res 2020 Feb 17;53(1). Epub 2020 Feb 17.

Department of Foot and Ankle Surgery, Honghui Hospital Affiliated to Xi'an Jiaotong University, No. 555 East Youyi Road, Xi'an, 710054, Shaanxi, China.

Background: Osteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients' daily life. It was reported that non-coding RNAs play vital roles in OA. However, the regulation mechanism of ncRNA in OA pathogenesis has not been fully elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00275-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027214PMC
February 2020

CtpB is a plasma membrane copper (I) transporting P-type ATPase of Mycobacterium tuberculosis.

Biol Res 2020 Feb 13;53(1). Epub 2020 Feb 13.

Chemistry Department, Faculty of Sciences, Universidad Nacional de Colombia, Carrera 30  N° 45-03, Ciudad Universitaria, Bogotá, Colombia.

Background: The intracellular concentration of heavy-metal cations, such as copper, nickel, and zinc is pivotal for the mycobacterial response to the hostile environment inside macrophages. To date, copper transport mediated by P-type ATPases across the mycobacterial plasma membrane has not been sufficiently explored.

Results: In this work, the ATPase activity of the putative Mycobacterium tuberculosis P-type ATPase CtpB was associated with copper (I) transport from mycobacterial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-00274-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017476PMC
February 2020

Linc-OIP5 in the breast cancer cells regulates angiogenesis of human umbilical vein endothelial cells through YAP1/Notch/NRP1 signaling circuit at a tumor microenvironment.

Biol Res 2020 Feb 11;53(1). Epub 2020 Feb 11.

Department of Pathology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, People's Republic of China.

Background: LincRNAs have been revealed to be tightly associated with various tumorigeneses and cancer development, but the roles of specific lincRNA on tumor-related angiogenesis was hardly studied. Here, we aimed to investigate whether linc-OIP5 in breast cancer cells affects the angiogenesis of HUVECs and whether the linc-OIP5 regulations are involved in angiogenesis-related Notch and Hippo signaling pathways.

Methods: A trans-well system co-cultured HUVECs with linc-OIP5 knockdown breast cancer cell MDA-MB-231 was utilized to study the proliferation, migration and tube formation abilities of HUVECs and alterations of related signaling indicators in breast cancer cells and their conditioned medium through a series of cell and molecular experiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-0273-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014737PMC
February 2020

The comprehensive detection of miRNA, lncRNA, and circRNA in regulation of mouse melanocyte and skin development.

Biol Res 2020 Feb 3;53(1). Epub 2020 Feb 3.

College of Life Science, Shanxi Agricultural University, Taigu, 030801, China.

Background: Pigmentation development, is a complex process regulated by many transcription factors during development. With the development of the RNA sequencing (RNA-seq), non-coding RNAs, such as miRNAs, lncRNAs, and circRNAs, are found to play an important role in the function detection of related regulation factors. In this study, we provided the expression profiles and development of ncRNAs related to melanocyte and skin development in mice with black coat color skin and mice with white coat color skin during embryonic day 15 (E15) and postnatal day 7 (P7). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-0272-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998077PMC
February 2020
1.480 Impact Factor

Comparison of protein profiles of the pellicle, gingival crevicular fluid, and saliva: possible origin of pellicle proteins.

Biol Res 2020 Jan 15;53(1). Epub 2020 Jan 15.

Department of Periodontology, Showa University School of Dentistry, Tokyo, Japan.

Background: The pellicle, the acellular organic material deposited on the surface of tooth enamel, has been thought to be derived from saliva. In this study, protein compositions of the pellicle, gingival crevicular fluid, and saliva collected from healthy adults were compared to elucidate the origin of pellicle proteins.

Results: The pellicle, gingival crevicular fluid, and saliva from the parotid gland or mixed gland were collected; subsequently, protein expression in samples from the respective individual was compared by SDS-PAGE and mass spectrometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-020-0271-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964095PMC
January 2020

Disentangling the genetic bases of Saccharomyces cerevisiae nitrogen consumption and adaptation to low nitrogen environments in wine fermentation.

Biol Res 2020 Jan 9;53(1). Epub 2020 Jan 9.

Departamento de Ciencia y Tecnología de los Alimentos, Universidad de Santiago de Chile (USACH), Santiago, Chile.

The budding yeast Saccharomyces cerevisiae has been considered for more than 20 years as a premier model organism for biological sciences, also being the main microorganism used in wide industrial applications, like alcoholic fermentation in the winemaking process. Grape juice is a challenging environment for S. cerevisiae, with nitrogen deficiencies impairing fermentation rate and yeast biomass production, causing stuck or sluggish fermentations, thus generating sizeable economic losses for wine industry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0270-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950849PMC
January 2020

SNHG1 promotes MPP-induced cytotoxicity by regulating PTEN/AKT/mTOR signaling pathway in SH-SY5Y cells via sponging miR-153-3p.

Biol Res 2020 Jan 6;53(1). Epub 2020 Jan 6.

Department of Neurology, Huaihe Hospital of Henan University, No. 357 Ximen Street, Kaifeng, 475000, China.

Background: Long non-coding RNA small molecule RNA host gene 1 (SNHG1) was previously identified to be relevant with Parkinson's disease (PD) pathogenesis. This work aims to further elucidate the regulatory networks of SNHG1 involved in PD.

Methods: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-hydrochloride (MPTP)-induced mice and 1-methyl-4-phenylpyridinium (MPP)-treated SH-SY5Y cells were respectively constructed as the in vivo and in vitro PD models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0267-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943908PMC
January 2020

LncRNA LINC00460 promotes the papillary thyroid cancer progression by regulating the LINC00460/miR-485-5p/Raf1 axis.

Biol Res 2019 Dec 23;52(1):61. Epub 2019 Dec 23.

Department of Oncology, The Affiliated Hospital of Jining Medical University, No. 89, Gutun Road, Jining, 272029, Shandong, China.

Background: Papillary thyroid cancer (PTC) is the most common malignancy of all thyroid cancers. LncRNA LINC00460 has been proved to play roles in the oncogenesis and progression of various tumors, including papillary thyroid cancer. However, the potential molecular mechanism of LINC00460 in PTC is poorly investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0269-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929379PMC
December 2019

RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway.

Biol Res 2019 Dec 17;52(1):60. Epub 2019 Dec 17.

Department of General Surgery, Shandong Provincial Hospital Affiliated to Shandong University, 324 JingwuWeiqi Road, Jinan, Shandong, 250021, People's Republic of China.

Background: Recent studies have confirmed that RASAL1 has an antitumor effect in many cancers, but its functional role and the molecular mechanism underlying in colon cancer has not been investigated.

Results: We collected human colon cancer tissues and adjacent non-tumor tissues, human colon cancer cell lines LoVo, CaCo2, SW1116, SW480 and HCT-116, and normal colonic mucosa cell line NCM460. RT-qPCR was used to detect the RASAL1 level in the clinical tissues and cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0268-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918686PMC
December 2019

FOXC2-AS1 regulates phenotypic transition, proliferation and migration of human great saphenous vein smooth muscle cells.

Biol Res 2019 Dec 4;52(1):59. Epub 2019 Dec 4.

Department of Vascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450002, Henan, China.

Objectives: In varicose veins, vascular smooth muscle cells (VSMCs) often shows phenotypic transition and abnormal proliferation and migration. Evidence suggests the FOXC2-Notch pathway may be involved in the pathogenesis of varicose veins. Here, this study aimed to explore the role of long non-coding RNA FOXC2-AS1 (FOXC2 antisense RNA 1) in phenotypic transition, proliferation, and migration of varicose vein-derived VSMCs and to explore whether the FOXC2-Notch pathway was involved in this process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0266-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894326PMC
December 2019

Long non-coding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy inhibition by regulating TSC2-mTOR signaling.

Biol Res 2019 Nov 29;52(1):58. Epub 2019 Nov 29.

Department of Cardiovascular, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 1 Swan Lake Road, Hefei, 230001, Anhui, People's Republic of China.

Background: Our previous study showed that knockdown of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) attenuated myocardial apoptosis in mouse acute myocardial infarction (AMI). This study aims to explore whether MALAT1 enhanced cardiomyocyte apoptosis via autophagy regulation and the underlying mechanisms of MALAT1 regulating autophagy.

Methods: Cardiomyocytes were isolated from neonatal mice and then stimulated with hypoxia/reoxygenation (H/R) injury to mimic AMI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0265-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883637PMC
November 2019

Gramicidin inhibits human gastric cancer cell proliferation, cell cycle and induced apoptosis.

Biol Res 2019 Nov 25;52(1):57. Epub 2019 Nov 25.

Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research (Bengbu Medical College), 287 Changhuai Road, Bengbu, 233004, Anhui Province, People's Republic of China.

Background: Gastric cancer is a common malignant tumor with high morbidity and mortality worldwide, which seriously affects human health. Gramicidin is a short peptide antibiotic which could be used for treating infection induced by bacteria or fungi. However, the anti-cancer effect of gramicidin on gastric cancer cells and its underlying mechanism remains largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0264-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878685PMC
November 2019
1.480 Impact Factor

PDIL1-2 can indirectly and negatively regulate expression of the AGPL1 gene in bread wheat.

Biol Res 2019 Nov 7;52(1):56. Epub 2019 Nov 7.

The National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, #15 Longzihu College District, Zhengzhou, 450046, China.

Background: ADP-glucose pyrophosphorylase (AGPase), the key enzyme in plant starch biosynthesis, is a heterotetramer composed of two identical large subunits and two identical small subunits. AGPase has plastidial and cytosolic isoforms in higher plants, whereas it is mainly detected in the cytosol of grain endosperms in cereal crops. Our previous results have shown that the expression of the TaAGPL1 gene, encoding the cytosolic large subunit of wheat AGPase, temporally coincides with the rate of starch accumulation and that its overexpression dramatically increases wheat AGPase activity and the rate of starch accumulation, suggesting an important role. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0263-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839113PMC
November 2019

Epanorin, a lichen secondary metabolite, inhibits proliferation of MCF-7 breast cancer cells.

Biol Res 2019 Oct 10;52(1):55. Epub 2019 Oct 10.

Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Av. Gran Bretaña 1093, Playa Ancha, CP 2360102, Valparaiso, Chile.

Background: Epanorin (EP) is a secondary metabolite of the Acarospora lichenic species. EP has been found in lichenic extracts with antimicrobial activity, and UV-absorption properties have been described for closely related molecules; however, its antiproliferative activity in cancer cells has not yet been explored. It has been hypothesized that EP inhibits cancer cell growth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0261-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786276PMC
October 2019
1 Read

IcarisideII facilitates the differentiation of ADSCs to SCs via let-7i/STAT3 axis to preserve erectile function.

Biol Res 2019 Oct 3;52(1):54. Epub 2019 Oct 3.

Department of Urology Surgery, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71, Baoshan North Road, Guiyang, 550001, Guizhou, China.

Background: IcarisideII (ICAII) could promote the differentiation of adipose tissue-derived stem cells (ADSCs) to Schwann cells (SCs), leading to improvement of erectile function (EF) and providing a realistic therapeutic option for the treatment of erectile dysfunction (ED). However, the underlying molecular mechanisms of ADSCs and ICAII in this process remain largely unclear.

Methods: ADSCs were treated with different concentrations of ICAII. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0262-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777035PMC
October 2019

Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells.

Biol Res 2019 Sep 21;52(1):53. Epub 2019 Sep 21.

Department of Endocrinology, The Six Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510655, People's Republic of China.

Background: Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0258-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754858PMC
September 2019

LncRNA XIST promotes extracellular matrix synthesis, proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury.

Biol Res 2019 Sep 20;52(1):52. Epub 2019 Sep 20.

Department of Plastic Surgery, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Rd, Wuhan, 430030, China.

Background: Long noncoding RNAs (lncRNAs) have been reported to be associated with dermis process during burn wound healing. This study aimed to investigate the role of lncRNA X-inactive specific transcript (XIST) in human skin fibroblasts (HSF) and extracellular matrix (ECM) as well as the regulatory network of XIST/microRNA-29b-3p (miR-29b-3p)/collagen 1 alpha 1 (COL1A1).

Methods: The wound samples were collected from 25 patients with deep partial thickness burn at day 5 after burn. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0260-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754631PMC
September 2019
3 Reads

Spores of Beauveria bassiana and Trichoderma lignorum as a bioinsecticide for the control of Atta cephalotes.

Biol Res 2019 Sep 17;52(1):51. Epub 2019 Sep 17.

Biotechnology Group, Universidad de San Buenaventura-Cali, Av 122# 6-65, Cali, 76001, Colombia.

Background: The leafcutter ant (Atta cephalotes) is associated with losses in the agricultural sector, due to its defoliating activity; for its control, biological, mechanical and chemical methods have been developed, the latter associated with adverse effects on human and environmental health. This research validated in the field for the control of the leafcutter ant (A. cephalotes) using a mixture of Beauveria bassiana and Trichoderma lignorum spores. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0259-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749709PMC
September 2019
1 Read

Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats.

Biol Res 2019 Sep 6;52(1):50. Epub 2019 Sep 6.

Renal Division, Department of Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.

Background: Ureteral obstruction causes injury of the renal tissues and can irreversibly progress to renal fibrosis, with atrophy and apoptosis of tubular cells. The goal of the current study was to examine the effects of rhein on the apoptosis o renal tubular cells as well as renal fibrosis using a rodent model of unilateral ureteral obstruction (UUO).

Methods: UUO was induced through ureteral ligation, then animals received treatments with rhein or vehicle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0257-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728983PMC
September 2019

Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease.

Biol Res 2019 Sep 6;52(1):49. Epub 2019 Sep 6.

Department of Mongolian Pharmacy, School of Mongol Medicine, Inner Mongolia University for Nationalities, 536 West of Huolinhe Street, Tongliao, 028000, Inner Mongolia, People's Republic of China.

Background: Psoriasis is a common and intractable skin disease affecting the physical and mental health of patients. The accumulation of ROS is involved in the pathogenesis of psoriasis and antioxidants are believed to be therapeutic. This study aimed to investigate the therapeutic efficacy of astilbin on ROS accumulation in psoriasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0255-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729080PMC
September 2019

Light-induced injury in mouse embryos revealed by single-cell RNA sequencing.

Biol Res 2019 Aug 29;52(1):48. Epub 2019 Aug 29.

Department of Regenerative Medicine, School of Medicine, Tongji University, Shanghai, 200092, China.

Background: Light exposure is a common stress factor in in vitro manipulation of embryos in the reproductive center. Many studies have shown the deleterious effects of high-intensity light exposure in different animal embryos. However, no transcriptomic studies have explored the light-induced injury and response in preimplantation embryos. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0256-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716870PMC
August 2019
2 Reads

Molecular aspects of the teratogenesis of rubella virus.

Biol Res 2019 Aug 28;52(1):47. Epub 2019 Aug 28.

Diagnostic Virology Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune, Maharashtra, 411001, India.

Rubella or German measles is an infection caused by rubella virus (RV). Infection of children and adults is usually characterized by a mild exanthematous febrile illness. However, RV is a major cause of birth defects and fetal death following infection in pregnant women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0254-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712747PMC
August 2019
3 Reads

Desiccation tolerance in the Antarctic moss Sanionia uncinata.

Biol Res 2019 Aug 21;52(1):46. Epub 2019 Aug 21.

Laboratorio de Fisiología y Biotecnología Vegetal, Departamento de Biología, Facultad de Química y Biología, and CEDENNA, Universidad de Santiago de Chile, Av. Libertador Bernardo O'Higgins 3363, Estación Central, Santiago, Chile.

Background: One of the most extreme environments on our planet is the Maritime Antarctic territory, due to its low-water availability, which restricts the development of plants. Sanionia uncinata Hedw. (Amblystegiaceae), the main colonizer of the Maritime Antarctic, has effective mechanisms to tolerate this environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0251-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704725PMC

Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells.

Biol Res 2019 Aug 19;52(1):44. Epub 2019 Aug 19.

Microbiology & Immunology Department, Dasman Diabetes Institute, P. O. Box 1180, 15462, Dasman, Kuwait.

Background: Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty acids (FFAs). Once activated, it promotes glucose-stimulated insulin secretion (GSIS). However, increased levels of FFAs lead to lipotoxicity, inducing loss of β-cell function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0253-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699284PMC
August 2019
2 Reads

Resveratrol reduces store-operated Ca entry and enhances the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats model via targeting ORAI1-STIM1 complex.

Biol Res 2019 Aug 19;52(1):45. Epub 2019 Aug 19.

Department of Histology and Embryology, Anhui Medical University, Meishan Road No. 81, Hefei, 230032, China.

Background: Resveratrol was reported to trigger the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats but the subcellular mechanism remains unclear. Since ER stress, mitochondrial dysfunction and oxidative stress were involved in the effects of resveratrol with imbalance of calcium bio-transmission, store operated calcium entry (SOCE), a novel intracellular calcium regulatory pathway, may also participate in this process.

Results: In the present study, Resveratrol was found to suppress ORAI1 expression of a dose dependent manner while have no evident effects on STIM1 expressive level. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0250-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699118PMC
August 2019
1 Read

Effects of deficit irrigation and kaolin application on vegetative growth and fruit traits of two early ripening apple cultivars.

Biol Res 2019 Aug 12;52(1):43. Epub 2019 Aug 12.

Department of Irrigation and Reclamation Engineering, College of Agriculture and Natural Resources, University of Tehran, Karaj, 31587, Iran.

Background: Drought is one of the main serious problems for agriculture production which its intensity is increasing in many parts of the world, hence, improving water use efficiency is a main goal for sustainable agriculture.

Results: Growth indices including relative shoot length growth (SL), relative stem diameter increase (SD) and relative trunk cross sectional area growth (TCSA) measured at the start and end of the season decreased by reducing the irrigation level. Chlorophyll index (CI) was decreased at 70% crop evapotranspiration, however water use efficiency (WUE), leaf and fruit total phenolic content (TPC), and fruit anthocyanin content (AC) were among the traits that showed increment by water deficit stress in both cultivars. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0252-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691532PMC
August 2019
1 Read

Protein expression profiles and clinicopathologic characteristics associate with gastric cancer survival.

Biol Res 2019 Aug 9;52(1):42. Epub 2019 Aug 9.

Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.

Background: Prognosis remains one of most crucial determinants of gastric cancer (GC) treatment, but current methods do not predict prognosis accurately. Identification of additional biomarkers is urgently required to identify patients at risk of poor prognoses.

Methods: Tissue microarrays were used to measure expression of nine GC-associated proteins in GC tissue and normal gastric tissue samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0249-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689162PMC
August 2019
1 Read
1.480 Impact Factor

A novel hydrazide compound exerts anti-metastatic effect against breast cancer.

Biol Res 2019 Aug 6;52(1):40. Epub 2019 Aug 6.

Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.

Background: There are currently a number of barriers hindering the successful treatment of breast cancer, including the metastatic spread of cancer cells. In looking for new anticancer agents, we reported two novel hydrazide derivatives with anti-cancer activity in human breast cancer cells. The current study aims to explore the therapeutic potential of the most effective one, N'-((5-nitrothiophen-2-yl)methylene)-2-(phenylthio)benzohydrazide (compound B), on metastatic breast cancer, which is resistant to available chemotherapeutics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0247-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683344PMC
August 2019
1.480 Impact Factor

Role of JNK and ERK1/2 MAPK signaling pathway in testicular injury of rats induced by di-N-butyl-phthalate (DBP).

Biol Res 2019 Aug 6;52(1):41. Epub 2019 Aug 6.

School of Public Health, Beihua University, Jilin, 132013, China.

Background: Di-N-butyl-phthalate (DBP) is an endocrine disrupting substance. We investigated the adverse effect of DBP on testis of male rat and reveal its potential mechanism of MAPK signaling pathway involved this effect in vivo and in vitro. Gonadal hormone, sperm quality, morphological change and the activation status of JNK, ERK1/2 and p38 was determined in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0248-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685163PMC
August 2019
2 Reads

Stress and defense responses in plant secondary metabolites production.

Authors:
Tasiu Isah

Biol Res 2019 Jul 29;52(1):39. Epub 2019 Jul 29.

Department of Botany, School of Chemical and Life Sciences, Hamdard University, New Delhi, 110 062, India.

In the growth condition(s) of plants, numerous secondary metabolites (SMs) are produced by them to serve variety of cellular functions essential for physiological processes, and recent increasing evidences have implicated stress and defense response signaling in their production. The type and concentration(s) of secondary molecule(s) produced by a plant are determined by the species, genotype, physiology, developmental stage and environmental factors during growth. This suggests the physiological adaptive responses employed by various plant taxonomic groups in coping with the stress and defensive stimuli. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0246-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661828PMC
July 2019
1.480 Impact Factor

miR-29b-3p promotes progression of MDA-MB-231 triple-negative breast cancer cells through downregulating TRAF3.

Biol Res 2019 Jul 26;52(1):38. Epub 2019 Jul 26.

School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510640, People's Republic of China.

Background: Breast cancer is the second common malignant cancer among females worldwide. Accumulating studies have indicated that deregulation of miRNA expression in breast cancer will contribute to tumorigenesis and form different cancer subtypes. However, the reported studies on miR-29b-3p-regulated breast cancer are limited so far. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0245-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659300PMC
July 2019
8 Reads

Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells.

Biol Res 2019 Jul 18;52(1):37. Epub 2019 Jul 18.

Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University, 301 Yanchang Road, Shanghai, 200072, China.

Background: Berberine (BBR), a compound extracted from a variety of medicinal herbs, has been shown multiple pharmacological effects against cancer cells of different origins. Cisplatin (DDP) is known as an effective chemotherapeutic agent against cancer by inducing DNA damage and cell apoptosis. However, the effect of the combined used of BBR and DDP on cell necroptosis in ovarian cancer has not been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0243-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637630PMC
July 2019
4 Reads

Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity.

Biol Res 2019 Jul 12;52(1):36. Epub 2019 Jul 12.

Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, 3 Xueyuan Road, Longhua District, Haikou, 571199, Hainan, People's Republic of China.

Background: Recent evidences indicated that some local anaesthetic agents played a role in inhibiting the proliferation of cancer cells; Whether ropivacaine is able to promote apoptosis of hepatocellular carcinoma (HCC) cells is still unclear. The aim of this study was to investigate the effect of ropivacaine on the apoptosis of HCC cells.

Methods: In the present study, we treated the HCC cell lines, Bel7402 and HLE with ropivacaine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0242-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625015PMC
July 2019
11 Reads
1.480 Impact Factor

TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells.

Biol Res 2019 Jul 11;52(1):35. Epub 2019 Jul 11.

Department of Science Education, Korea National University of Education, Cheongju-si, Chungbuk, 28173, Republic of Korea.

Background: Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. NSCLC diagnosed at an early stage can be highly curable with a positive prognosis, but biomarker limitations make it difficult to diagnose lung cancer at an early stage. To identify biomarkers for lung cancer development, we previously focused on the oncogenic roles of transcription factor TFAP2C in lung cancers and revealed the molecular mechanism of several oncogenes in lung tumorigenesis based on TFAP2C-related microarray analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0244-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625030PMC
July 2019
1 Read

Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells.

Biol Res 2019 Jul 5;52(1):34. Epub 2019 Jul 5.

Basic Medical School of Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.

Background: Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. However, the antitumor mechanism of psoralen is not fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0241-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612100PMC
July 2019
3 Reads