1,191 results match your criteria Biological research[Journal]


RNA editing analysis of ATP synthase genes in the cotton cytoplasmic male sterile line H276A.

Biol Res 2019 Feb 6;52(1). Epub 2019 Feb 6.

Key Laboratory of Plant Genetic and Breeding, College of Agriculture, Guangxi University, Nanning, 530005, People's Republic of China.

Background: Pollen development is an energy-consuming process that particularly occurs during meiosis. Low levels of adenosine triphosphate (ATP) may cause cell death, resulting in CMS (cytoplasmic male sterility). DNA sequence differences in ATP synthase genes have been revealed between the N- and S-cytoplasms in the cotton CMS system. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-019-0212-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364438PMC
February 2019
2 Reads

Identification of the targets of hematoporphyrin derivative in lung adenocarcinoma using integrated network analysis.

Authors:
Hongtao Yin Yan Yu

Biol Res 2019 Feb 4;52(1). Epub 2019 Feb 4.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin, 150081, Heilongjiang, China.

Background: Hematoporphyrin derivative (HPD) has a sensibilization effect in lung adenocarcinoma. This study was conducted to identify the target genes of HPD in lung adenocarcinoma.

Methods: RNA sequencing was performed using the lung adenocarcinoma cell line A549 after no treatment or treatment with X-ray or X-ray + HPD. Read More

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http://dx.doi.org/10.1186/s40659-019-0213-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360726PMC
February 2019

Isolation and partial characterization of a new moderate thermophilic Albidovulum sp. SLM16 with transaminase activity from Deception Island, Antarctica.

Biol Res 2019 Feb 4;52(1). Epub 2019 Feb 4.

Fundación Científica y Cultural Biociencia, José Domingo Cañas 2280, Santiago, Chile.

Background: A moderately thermophilic, slightly halophilic, aerobic, Gram-stain negative, bacterial strain, SLM16, was isolated from a mixed of seawater-sand-sediment sample collected from a coastal fumarole located in Whalers Bay, Deception Island, Antarctica. The aim was to screen for thermophilic microorganisms able to degrade primary amines and search for amine transaminase activity for potential industrial application.

Results: Identification and partial characterization of the microorganism SLM16 were carried out by means of morphological, physiological and biochemical tests along with molecular methods. Read More

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http://dx.doi.org/10.1186/s40659-018-0210-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360757PMC
February 2019

De novo in vitro shoot morphogenesis from shoot tip-induced callus cultures of Gymnema sylvestre (Retz.) R.Br. ex Sm.

Authors:
Tasiu Isah

Biol Res 2019 Jan 19;52(1). Epub 2019 Jan 19.

Department of Botany, School of Chemical and Life Sciences, Hamdard University, New Delhi, 110 062, India.

Background: Gymnema sylvestre is a medicinal woody perennial vine known for its sweetening properties and anti-diabetic therapeutic uses in the modern and traditional medicines. Its over-exploitation for the therapeutic uses and to meet the demand of pharmaceutical industry in raw materials supply for the production of anti-diabetic drugs has led to considerable decline in its natural population.

Results: An efficient system of shoot bud sprouting from nodal segment explants and indirect plant regeneration from apical meristem-induced callus cultures of G. Read More

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http://dx.doi.org/10.1186/s40659-019-0211-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339694PMC
January 2019
1 Read
1.480 Impact Factor

ErbB1 and ErbB3 co-over expression as a prognostic factor in gastric cancer.

Biol Res 2019 Jan 8;52(1). Epub 2019 Jan 8.

Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. Although, there are various reports about the prognostic value of EGFR members separately in gastric cancer, there is not any report about the probable correlation between ErbB1 and ErbB3 co-expression and gastric cancer prognosis. In present study, we assessed the correlation between ErbB1 and ErbB3 co-overexpression (in the level of mRNA and protein expression) and gastric cancer prognosis for the first time. Read More

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http://dx.doi.org/10.1186/s40659-018-0208-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323733PMC
January 2019
1 Read

Isolation of dihydrobenzofuran derivatives from ethnomedicinal species Polygonum barbatum as anticancer compounds.

Biol Res 2019 Jan 7;52(1). Epub 2019 Jan 7.

Department of Pharmacy, University of Malakand, Dir (L), Chakdara, 18000, KP, Pakistan.

Background: Ethnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of this family have been reported with anticancer potentials. This study was designed to isolate anticancer compounds from ethnomedicinally important species Polygonum barbatum. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0209-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322347PMC
January 2019
7 Reads

Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling.

Biol Res 2018 Dec 29;51(1):58. Epub 2018 Dec 29.

Reproductive Medical Center, Department of Gynecology and Obstetrics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Studies have demonstrated that transforming growth factor beta-1 (TGF-β1) exhibits oncogenic activity in different types of cancer, including ovarian cancer (OC). However, its regulatory mechanism in OC and whether TGF-β1 is involved in chemosensitivity regulation remains unclear. Thus, the aim of this study was to investigate the role of TGF-β1 in OC. Read More

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http://dx.doi.org/10.1186/s40659-018-0205-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310971PMC
December 2018
2 Reads

Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits.

Biol Res 2018 Dec 20;51(1):57. Epub 2018 Dec 20.

Laboratorio de Neurobiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it's impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial blood pressure, heart rate and heart rate variability (HRV) in rabbits subjected to chronic normobaric hypoxia (CNH; PB ~ 719 mmHg; FO ~ 9.2%) for 14 days and assess the effect of autonomic control by acute bilateral vagal denervation. Read More

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http://dx.doi.org/10.1186/s40659-018-0207-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300919PMC
December 2018
1 Read
1.480 Impact Factor

MicroRNA-153-3p enhances cell radiosensitivity by targeting BCL2 in human glioma.

Biol Res 2018 Dec 11;51(1):56. Epub 2018 Dec 11.

Department of Neurosurgery, Liaoning Cancer Hospital & Institute, No.44 Xiao Heyan Street, Shenyang, 110042, Liaoning, China.

Background: Glioma is the most prevalent malignant tumor in human central nervous systems. Recently, the development of resistance to radiotherapy in glioma patients markedly vitiates the therapy outcome. MiR-153-3p has been reported to be closely correlated with tumor progression, but its effect and molecular mechanism underlying radioresistance remains unclear in glioma. Read More

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http://dx.doi.org/10.1186/s40659-018-0203-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288870PMC
December 2018
1 Read

A thermophilic microorganism from Deception Island, Antarctica with a thermostable glutamate dehydrogenase activity.

Biol Res 2018 Dec 8;51(1):55. Epub 2018 Dec 8.

Fundación Científica y Cultural Biociencia, José Domingo Cañas 2280, Santiago, 7750132, Chile.

Background: The Antarctic continent is a source of extreme microorganisms. Millions of years of isolation have produced unique biodiversity with adaptive responses to its extreme environment. Although the Antarctic climate is mainly cold, the presence of several geothermal sites, including thermal springs, fumaroles, hot soils and hydrothermal vents, provides ideal environments for the development of thermophilic and hyperthermophilic microorganisms. Read More

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http://dx.doi.org/10.1186/s40659-018-0206-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286571PMC
December 2018
2 Reads

The deubiquitinase USP38 affects cellular functions through interacting with LSD1.

Biol Res 2018 Nov 29;51(1):53. Epub 2018 Nov 29.

College of Health Sciences and Nursing, Wuhan Polytechnic University, No. 68 Southern Xuefu Road, Wuhan, 430023, Hubei, China.

Background: Deubiquitination is a posttranslational protein modification prevalent in mammalian cells. Deubiquitinases regulate the functions of the target protein by removing its ubiquitin chain. In this study, the effects of the deubiquitinase USP38's functions on the LSD1 protein and on cell physiology were investigated. Read More

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http://dx.doi.org/10.1186/s40659-018-0201-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263071PMC
November 2018
1 Read
1.480 Impact Factor

Effect of urea-extracted sericin on melanogenesis: potential applications in post-inflammatory hyperpigmentation.

Biol Res 2018 Nov 29;51(1):54. Epub 2018 Nov 29.

Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Ratchawithi Road, Ratchathewi, Bangkok, 10400, Thailand.

Background: Hyperpigmentation disorders such as post-inflammatory hyperpigmentation are major concerns not only in light-skinned people but also in Asian populations with darker skin. The anti-tyrosinase and immunomodulatory effects of sericin have been known for decades. However, the therapeutic effects of sericin on hyperpigmentation disorders have not been well documented. Read More

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http://dx.doi.org/10.1186/s40659-018-0204-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262948PMC
November 2018
9 Reads

Overexpression of PIK3R1 promotes hepatocellular carcinoma progression.

Biol Res 2018 Nov 29;51(1):52. Epub 2018 Nov 29.

The Key Laboratory of Medical Molecular Biology, Guizhou Medical University, Guiyang, 550002, China.

Background: Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could regulate cancer cell proliferation important for cancer cell proliferation; however, its role in Hepatocellular carcinoma (HCC) remains largely unknown. Here, we investigated the role of PIK3R1 in HCC and examined the underlying molecular mechanisms.

Methods: The expression of PIK3R1 was evaluated by immunohistochemistry and qRT-PCR in a series of HCC tissues. Read More

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http://dx.doi.org/10.1186/s40659-018-0202-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264640PMC
November 2018
6 Reads

MiR-219-5p inhibits growth and metastasis of ovarian cancer cells by targeting HMGA2.

Biol Res 2018 Nov 24;51(1):50. Epub 2018 Nov 24.

Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, No 301 Middle Yan Chang Road, Shanghai, 200072, China.

Background: Accumulating studies have demonstrated that high-mobility group A2 (HMGA2), an oncofetal protein, plays a role in tumor development and progression. However, the molecular role of HMGA2 in ovarian carcinoma is yet to be established. MicroRNAs (miRNAs), a group of small noncoding RNAs, negatively regulate gene expression and their dysregulation has been implicated in tumorigenesis. Read More

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http://dx.doi.org/10.1186/s40659-018-0199-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260846PMC
November 2018
4 Reads

MicroRNA-382 inhibits cell growth and migration in colorectal cancer by targeting SP1.

Biol Res 2018 Nov 24;51(1):51. Epub 2018 Nov 24.

Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, NO.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, People's Republic of China.

Background: Emerging evidence showed that microRNAs (miRs) play critical roles in human cancers by functioning as either tumor suppressor or oncogene. MIR-382 was found to function as tumor suppressor in certain cancers. However, the role of MIR-382 in colorectal cancer (CRC) is largely unknown. Read More

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http://dx.doi.org/10.1186/s40659-018-0200-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260849PMC
November 2018
2 Reads

Photoprotection enhanced by red cell wall pigments in three East Antarctic mosses.

Biol Res 2018 Nov 21;51(1):49. Epub 2018 Nov 21.

Centre for Sustainable Ecosystem Solutions, School of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia.

Background: Antarctic bryophytes (mosses and liverworts) are resilient to physiologically extreme environmental conditions including elevated levels of ultraviolet (UV) radiation due to depletion of stratospheric ozone. Many Antarctic bryophytes synthesise UV-B-absorbing compounds (UVAC) that are localised in their cells and cell walls, a location that is rarely investigated for UVAC in plants. This study compares the concentrations and localisation of intracellular and cell wall UVAC in Antarctic Ceratodon purpureus, Bryum pseudotriquetrum and Schistidium antarctici from the Windmill Islands, East Antarctica. Read More

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http://dx.doi.org/10.1186/s40659-018-0196-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247747PMC
November 2018
8 Reads

Coping with drought: stress and adaptive mechanisms, and management through cultural and molecular alternatives in cotton as vital constituents for plant stress resilience and fitness.

Biol Res 2018 Nov 14;51(1):47. Epub 2018 Nov 14.

The Key Laboratory of Oasis Eco-agriculture, Xinjiang Production and Construction Group, Shihezi University, Shihezi, 832003, People's Republic of China.

Increased levels of greenhouse gases in the atmosphere and associated climatic variability is primarily responsible for inducing heat waves, flooding and drought stress. Among these, water scarcity is a major limitation to crop productivity. Water stress can severely reduce crop yield and both the severity and duration of the stress are critical. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0198-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234603PMC
November 2018
13 Reads
1.480 Impact Factor

Copper stress induces antioxidant responses and accumulation of sugars and phytochelatins in Antarctic Colobanthus quitensis (Kunth) Bartl.

Biol Res 2018 Nov 14;51(1):48. Epub 2018 Nov 14.

Laboratorio de Fisiología y Biotecnología Vegetal, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, L.B. O'Higgins #3363, Estación Central, Santiago, Chile.

Background: In field, C. quitensis is subjected to many abiotic extreme environmental conditions, such as low temperatures, high UV-B, salinity and reduced water potentials, but not metal or metalloid high concentrations in soil, however, other members of Caryophyllaceae family have tolerance to high concentrations of metals, this is the case of Silene genre. In this work, we hypothesize that C. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0197-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234666PMC
November 2018
8 Reads

The physiological and molecular mechanism of brassinosteroid in response to stress: a review.

Biol Res 2018 Nov 12;51(1):46. Epub 2018 Nov 12.

The Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

The negative effects of environmental stresses, such as low temperature, high temperature, salinity, drought, heavy metal stress, and biotic stress significantly decrease crop productivity. Plant hormones are currently being used to induce stress tolerance in a variety of plants. Brassinosteroids (commonly known as BR) are a group of phytohormones that regulate a wide range of biological processes that lead to tolerance of various stresses in plants. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0195-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231256PMC
November 2018
12 Reads

Identification of key genes and miRNAs markers of papillary thyroid cancer.

Biol Res 2018 Nov 10;51(1):45. Epub 2018 Nov 10.

Otolaryngology Head and Neck Surgery, Qingdao Municipal Hospital, No. 5 Donghai Road, Qingdao, 266071, Shandong, China.

Objective: In this study, crucial genes and microRNAs (miRNAs) associated with the progression, staging, and prognosis of papillary thyroid cancer (PTC) were identified.

Methods: Four PTC datasets, including our own mRNA-sequencing (mRNA-seq) dataset and three public datasets downloaded from Gene Expression Omnibus and The Cancer Genome Atlas, were used to analyze differentially expressed genes (DEGs) and miRNAs (DEMs) between PTC tumor tissues and paired normal tissues (control). Gene ontology (GO) terms and pathways associated with these DEGs were identified, and protein-protein interactions (PPIs) were analyzed. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0188-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230289PMC
November 2018
12 Reads

Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer.

Biol Res 2018 Nov 3;51(1):44. Epub 2018 Nov 3.

Department of Gastrointestinal and Colorectal Surgery, China-Japan Union Hospital, Jilin University, No.126, Xiantai Street, Changchun, 130033, China.

Background: Emerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the molecular mechanisms of GC by comprehensive analysis of mRNAs and miRNA expression profiles.

Methods: The mRNA and miRNA expression profiles of GSE79973 and GSE67354 downloaded from Gene Expression Omnibus were used to analyze the differentially expressed genes (DEGs) and DE-miRNAs among GC tissues and normal tissues. Read More

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http://dx.doi.org/10.1186/s40659-018-0192-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215350PMC
November 2018
2 Reads

Identification and characterization of circRNAs involved in the regulation of low nitrogen-promoted root growth in hexaploid wheat.

Biol Res 2018 Nov 3;51(1):43. Epub 2018 Nov 3.

College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.

Background: CircRNAs are widespread in plants and play important roles in response to abiotic stresses. Low nitrogen (LN) promotes the growth of plant root system, allowing it to explore more nitrogen. However, whether circRNAs involved in the response to LN stress and the regulation of LN-promoted root growth in wheat remains unclear. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0194-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215338PMC
November 2018
11 Reads

Priming stem cells with protein kinase C activator enhances early stem cell-chondrocyte interaction by increasing adhesion molecules.

Biol Res 2018 Nov 1;51(1):41. Epub 2018 Nov 1.

Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, South Korea.

Background: Osteoarthritis (OA) can be defined as degradation of articular cartilage of the joint, and is the most common degenerative disease. To regenerate the damaged cartilage, different experimental approaches including stem cell therapy have been tried. One of the major limitations of stem cell therapy is the poor post-transplantation survival of the stem cells. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0191-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211543PMC
November 2018
2 Reads

Development and characterization of microsatellite markers in Gaultheria pumila Lf. (Ericaceae).

Biol Res 2018 Nov 1;51(1):42. Epub 2018 Nov 1.

Verdant BioScience Pte. Ltda, 18, Duxton Hill, Singapore, 089601, Singapore.

Background: Polymorphic microsatellite markers were developed for Gaultheria pumila (Ericaceae) to evaluate genetic diversity and population structure within its native range in Chile. This is a very important Ericaceae endemic to Chile with a large commercial potential. Its resistance to different abiotic conditions makes it a valuable target for genetic improvement. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0193-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211410PMC
November 2018
11 Reads

High-throughput micro-phenotyping measurements applied to assess stalk lodging in maize (Zea mays L.).

Biol Res 2018 Oct 27;51(1):40. Epub 2018 Oct 27.

Beijing Key Lab of Digital Plant, Beijing Research Center for Information Technology in Agriculture, Beijing Academy of Agriculture and Forestry Sciences, Shuguang Huayuan Middle Road, Haidian District, No. 11, Beijing, 100097, People's Republic of China.

Background: The biomechanical properties of maize stalks largely determine their lodging resistance, which affects crop yield per unit area. However, the quantitative and qualitative relationship between micro-phenotypes and the biomechanics of maize stalks is still under examined. In particular, the roles of the number, geometry, and distribution of vascular bundles of stalks in maize lodging resistance remain unclear. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0190-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203980PMC
October 2018
13 Reads

Knockdown of SETDB1 inhibits breast cancer progression by miR-381-3p-related regulation.

Biol Res 2018 Oct 11;51(1):39. Epub 2018 Oct 11.

Department of Oncology, The Affiliated Hospital of Qinghai University, No. 29, Tongren Rd, Xining, 810001, Qinghai, China.

Background: SET domain bifurcated 1 (SETDB1) has been widely considered as an oncogene playing a critical role in many human cancers, including breast cancer. Nevertheless, the molecular mechanism by which SETDB1 regulates breast cancer tumorigenesis is still unknown.

Methods: qRT-PCR assay or western blot analysis was performed to assess the expression level of SETDB1 mRNA or protein, respectively. Read More

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http://dx.doi.org/10.1186/s40659-018-0189-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180515PMC
October 2018
2 Reads
1.480 Impact Factor

ADAR1-mediated RNA-editing of 3'UTRs in breast cancer.

Biol Res 2018 Oct 5;51(1):36. Epub 2018 Oct 5.

Center of Excellence in Precision Medicine, Pfizer Chile, Obispo Arturo Espinoza Campos 2526, 7810305, Santiago, Chile.

Background: Whole transcriptome RNA variant analyses have shown that adenosine deaminases acting on RNA (ADAR) enzymes modify a large proportion of cellular RNAs, contributing to transcriptome diversity and cancer evolution. Despite the advances in the understanding of ADAR function in breast cancer, ADAR RNA editing functional consequences are not fully addressed.

Results: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. Read More

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http://dx.doi.org/10.1186/s40659-018-0185-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172785PMC
October 2018
3 Reads

Biotechnological applications of archaeal enzymes from extreme environments.

Biol Res 2018 Oct 5;51(1):37. Epub 2018 Oct 5.

Fundación Científica y Cultural Biociencia, José Domingo Cañas, 2280, Santiago, Chile.

To date, many industrial processes are performed using chemical compounds, which are harmful to nature. An alternative to overcome this problem is biocatalysis, which uses whole cells or enzymes to carry out chemical reactions in an environmentally friendly manner. Enzymes can be used as biocatalyst in food and feed, pharmaceutical, textile, detergent and beverage industries, among others. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0186-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172850PMC
October 2018
2 Reads

Involvement of K and Ca channels in hydrogen sulfide-suppressed ageing of porcine oocytes.

Biol Res 2018 Oct 5;51(1):38. Epub 2018 Oct 5.

Institute of Animal Science, Uhrineves, Prague 10, Czech Republic.

Background: Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydrogen sulfide in gametes and embryos remains unknown. Our observations confirmed the hypothesis that the K and L-type Ca ion channels play roles in porcine oocyte ageing and revealed a plausible contribution of hydrogen sulfide to the modulation of ion channel activity. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0187-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172760PMC
October 2018
16 Reads

Thiamine deficiency contributes to synapse and neural circuit defects.

Biol Res 2018 Sep 19;51(1):35. Epub 2018 Sep 19.

Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Background: The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer's disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitive impairment. The reduction of thiamine diphosphate may contribute to the dysfunction of synapses and neural circuits, finally leading to cognitive decline.

Results: To demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density. Read More

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http://dx.doi.org/10.1186/s40659-018-0184-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145320PMC
September 2018
2 Reads

Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice.

Biol Res 2018 Sep 15;51(1):34. Epub 2018 Sep 15.

Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay #362 - 4º, Piso, 8330024, Santiago, Chile.

Background And Aims: Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been proposed as atheroprotective agents for cardiovascular disease management. However, their effects and benefits on high density lipoprotein function and remodeling are unknown. Read More

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http://dx.doi.org/10.1186/s40659-018-0183-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138920PMC
September 2018
3 Reads

Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis.

Biol Res 2018 Sep 5;51(1):33. Epub 2018 Sep 5.

Laboratory of Translational Physiology, Health Sciences Center, Federal University of Espirito Santo (UFES), Vitoria, Brazil.

Background: New evidence demonstrates that aging and dyslipidemia are closely associated with oxidative stress, DNA damage and apoptosis in some cells and extravascular tissues. However, in monocytes, which are naturally involved in progression and/or resolution of plaque in atherosclerosis, this concurrence has not yet been fully investigated. In this study, we evaluated the influence of aging and hypercholesterolemia on serum pro-inflammatory cytokines, oxidative stress, DNA damage and apoptosis in monocytes from apolipoprotein E-deficient (apoE) mice compared with age-matched wild-type C57BL/6 (WT) mice. Read More

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http://dx.doi.org/10.1186/s40659-018-0182-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123971PMC
September 2018
2 Reads

miR-214 ameliorates acute kidney injury via targeting DKK3 and activating of Wnt/β-catenin signaling pathway.

Biol Res 2018 Sep 4;51(1):31. Epub 2018 Sep 4.

Department of Nephrology, Huaihe Hospital of Henan University, No. 8, Baobei Road, Gulou District, Kaifeng, 475000, China.

Background: miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury (AKI) and its underlying mechanism are still largely unknown.

Methods: In this study, an I/R-induced rat AKI model and a hypoxia-induced NRK-52E cell model were used to study AKI. Read More

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http://dx.doi.org/10.1186/s40659-018-0179-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122444PMC
September 2018
7 Reads

Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes.

Biol Res 2018 Sep 4;51(1):30. Epub 2018 Sep 4.

College of Biotechnology, Guilin Medical University, Guilin, 541100, Guangxi, People's Republic of China.

Background: Psoriasis is a complex, chronic inflammatory skin disease with substantial negative effects on patient quality of life. Long non-coding RNAs (lncRNAs) are able to be involved in multitudes of cellular processes in diverse human diseases. This study aimed to investigate the potential involvement of lncRNA MIR31HG in HaCaT keratinocytes proliferation. Read More

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http://dx.doi.org/10.1186/s40659-018-0181-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122774PMC
September 2018
2 Reads

Minimal residual disease in prostate cancer patients after primary treatment: theoretical considerations, evidence and possible use in clinical management.

Authors:
Nigel P Murray

Biol Res 2018 Sep 4;51(1):32. Epub 2018 Sep 4.

Circulating Tumor Cell Unit, Faculty of Medicine, University Finis Terrae, Av Pedro de Valdivia 1509, Providencia, Santiago, Chile.

Minimal residual disease is that not detected by conventional imaging studies and clinically the patient remains disease free. However, with time these dormant cells will awaken and disease progression occurs, resulting in clinically and radiological detectable metastatic disease. This review addresses the concept of tumor cell dissemination from the primary tumor, the micrometastatic niche and tumor cell survival and finally the clinical utility of detecting and characterizing these tumor cells in order to guide management decisions in treating patients with prostate cancer. Read More

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http://dx.doi.org/10.1186/s40659-018-0180-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122199PMC
September 2018
1 Read

Contributions to the bryological knowledge of ASPA 125, Fildes Peninsula, King George Island.

Biol Res 2018 Aug 30;51(1):29. Epub 2018 Aug 30.

Departamento de Botânica, Universidade de Brasília, Campos Universitário Darcy Ribeiro, Asa Norte, Brasília, Distrito Federal, 70910, Brazil.

Background: With 29 Km, the Fildes Peninsula is the largest ice free area in King George Island and probably in Antarctica. The region is house of six permanent bases including the only airport in the South Shetlands, which led to impacts on its original landscape and vegetation. In recognition for the need to protect natural values, an Antarctic Specially Protected Area (ASPA 125) was established in the region. Read More

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http://dx.doi.org/10.1186/s40659-018-0178-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116545PMC
August 2018
1 Read

Cold-active pectinolytic activity produced by filamentous fungi associated with Antarctic marine sponges.

Biol Res 2018 Aug 27;51(1):28. Epub 2018 Aug 27.

Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Alameda 3363, Estación Central, 9170022, Santiago, Chile.

Background: Pectinase enzymes catalyze the breakdown of pectin, a key component of the plant cell wall. At industrial level, pectinases are used in diverse applications, especially in food-processing industry. Currently, most of the industrial pectinases have optimal activity at mesophilic temperatures. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-018-0177-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109986PMC
August 2018
12 Reads

Bioinformatics analysis of microarray data to reveal the pathogenesis of diffuse intrinsic pontine glioma.

Biol Res 2018 Aug 20;51(1):26. Epub 2018 Aug 20.

Department of Rehabilitation, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, 200080, China.

Background: Diffuse intrinsic pontine glioma (DIPG) is the main cause of pediatric brain tumor death. This study was designed to identify key genes associated with DIPG.

Methods: The gene expression profile GSE50021, which consisted of 35 pediatric DIPG samples and 10 normal brain samples, was downloaded from the Gene Expression Omnibus database. Read More

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http://dx.doi.org/10.1186/s40659-018-0175-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100713PMC
August 2018
6 Reads
1.480 Impact Factor

Missing and overexpressing proteins in domestic cat oocytes following vitrification and in vitro maturation as revealed by proteomic analysis.

Biol Res 2018 Aug 20;51(1):27. Epub 2018 Aug 20.

Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.

Background: The domestic cat serves as an animal model for assisted reproductive studies of endangered felid species. To date, there are no data on the protein alterations following cryopreservation of oocytes in felid family.

Methods: Immature (germinal vesicle) domestic cat oocytes were vitrified in the vitrification solution containing 35% ethylene glycol, 20% DMSO and 0. Read More

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http://dx.doi.org/10.1186/s40659-018-0176-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100730PMC
August 2018
9 Reads

Identification of key genes and pathways involved in response to pain in goat and sheep by transcriptome sequencing.

Biol Res 2018 Aug 17;51(1):25. Epub 2018 Aug 17.

College of life Science, Inner Mongolia Agricultural University, No. 306 Zhaowuda Road, Saihan District, Hohhot, 010018, People's Republic of China.

Purpose: This aim of this study was to investigate the key genes and pathways involved in the response to pain in goat and sheep by transcriptome sequencing.

Methods: Chronic pain was induced with the injection of the complete Freund's adjuvant (CFA) in sheep and goats. The animals were divided into four groups: CFA-treated sheep, control sheep, CFA-treated goat, and control goat groups (n = 3 in each group). Read More

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http://dx.doi.org/10.1186/s40659-018-0174-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098572PMC
August 2018
6 Reads

Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.

Biol Res 2018 Aug 10;51(1):24. Epub 2018 Aug 10.

Department of Breast Surgery, The Affiliated Zhongshan Hospital of Xiamen University, No. 201, Hubin South Road, Xiamen, 361000, Fujian, China.

Background: Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), an enzyme required for de novo purine biosynthesis, is associated with and involved in tumorigenesis. This study aimed to evaluate the role of PAICS in human breast cancer, which remains the most frequently diagnosed cancer and the leading cause of cancer-related death among women in less developed countries.

Results: Lentivirus-based short hairpin RNA targeting PAICS specifically depleted its endogenous expression in ZR-75-30 and MDA-MB-231 breast cancer cells. Read More

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http://dx.doi.org/10.1186/s40659-018-0172-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086025PMC
August 2018
2 Reads

A Nexus model of cellular transition in cancer.

Biol Res 2018 Aug 7;51(1):23. Epub 2018 Aug 7.

Department of Pharmaceutical Sciences, Softvision College and Research Institute, Vijaynagar, Indore, MP, 452010, India.

The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the cause. The model of cancer proposed herein, provides a link between the cellular biochemistry and cellular genetics of cancer evolution. Read More

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http://dx.doi.org/10.1186/s40659-018-0173-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080350PMC
August 2018
2 Reads

Protective roles of autophagy in retinal pigment epithelium under high glucose condition via regulating PINK1/Parkin pathway and BNIP3L.

Biol Res 2018 Jul 16;51(1):22. Epub 2018 Jul 16.

Ophthalmology Hospital, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, 150001, China.

Background: Our study aimed to investigate the roles of autophagy against high glucose induced response in retinal pigment epithelium (ARPE-19 cells).

Methods: The morphological changes and reactive oxygen species (ROS) generation in ARPE-19 cells under high glucose treatment were respectively detected using the transmission electron microscopy and flow cytometry. The expression levels of Parkin, PINK1, BNIP3L, LC3-I and LC3-II in ARPE-19 cells received high glucose treatment were measured by western blot after pretreatment of carbonyl cyanide m-chlorophenylhydrazone (CCCP), 3-methyladenine (3-MA), N-acetyl cysteine (NAC) or cyclosporin A (CsA) followed by high glucose treatment. Read More

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http://dx.doi.org/10.1186/s40659-018-0169-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047129PMC
July 2018
15 Reads

Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice.

Biol Res 2018 Jul 6;51(1):21. Epub 2018 Jul 6.

College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, Fujian, People's Republic of China.

Objective: To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease.

Methods: N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot.

Results: EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. Read More

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http://dx.doi.org/10.1186/s40659-018-0166-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034239PMC
July 2018
24 Reads

Expression of Concern to: Knockdown of ZFR suppresses cell proliferation and invasion of human pancreatic cancer.

Biol Res 2018 06 22;51(1):20. Epub 2018 Jun 22.

Department of Laboratory Medicine, Chengdu Military General Hospital, Chengdu, 610083, China.

Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5'-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3') as a non-targeting control and similarities in text and formatting with other published articles. This is currently under investigation and appropriate editorial action will be taken once the investigation is concluded. The authors did not respond to our correspondence regarding this expression of concern. Read More

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http://dx.doi.org/10.1186/s40659-018-0171-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013993PMC
June 2018
3 Reads

Expression of Concern to: Lentivirus mediated silencing of Ubiquitin Specific Peptidase 39 inhibits cell proliferation of human hepatocellular carcinoma cells in vitro.

Biol Res 2018 06 22;51(1):19. Epub 2018 Jun 22.

The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China.

Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5'-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3') as a non-targeting control and similarities in text and formatting with other published articles. This is currently under investigation and appropriate editorial action will be taken once the investigation is concluded. The authors agree. Read More

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http://dx.doi.org/10.1186/s40659-018-0170-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013891PMC
June 2018
18 Reads

Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells.

Biol Res 2018 Jun 13;51(1):18. Epub 2018 Jun 13.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.

Background: Arsenic trioxide (AsO), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB). The tyrosine kinase receptor (Trk) family comprises three members, namely TrkA, TrkB and TrkC. Various studies have confirmed that TrkA and TrkC expression is associated with a good prognosis in NB, while TrkB overexpression can lead to tumor cell growth and invasive metastasis. Read More

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http://dx.doi.org/10.1186/s40659-018-0167-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998579PMC
June 2018
10 Reads

Melatonin ameliorates HO-induced oxidative stress through modulation of Erk/Akt/NFkB pathway.

Biol Res 2018 Jun 11;51(1):17. Epub 2018 Jun 11.

Fish Endocrinology Research Unit, Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, West Bengal, 700019, India.

Background: Improper control on reactive oxygen species (ROS) elimination process and formation of free radicals causes tissue dysfunction. Pineal hormone melatonin is considered a potent regulator of such oxidative damage in different vertebrates. Aim of the current communication is to evaluate the levels of oxidative stress and ROS induced damage, and amelioration of oxidative status through melatonin induced activation of signaling pathways. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
Publisher Site
http://dx.doi.org/10.1186/s40659-018-0168-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996524PMC
June 2018
18 Reads

The effect of downregulation of Stathmin gene on biological behaviors of U373 and U87-MG glioblastoma cells.

Biol Res 2018 Jun 8;51(1):16. Epub 2018 Jun 8.

Department of Oncology, Peace Hospital of Changzhi Medical College, Changzhi, 046000, Shanxi, China.

Background: Stathmin as a critical protein involved in microtubule polymerization, is necessary for survival of cancer cells. However, extremely little is known about Stathmin in glioblastoma. So, this study was designed to elucidate the function of Stathmin gene in the tumorigenesis and progression of glioblastoma cells. Read More

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http://dx.doi.org/10.1186/s40659-018-0160-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992777PMC
June 2018
10 Reads

Extracellular matrix and fibroblast injection produces pterygium-like lesion in rabbits.

Biol Res 2018 Jun 5;51(1):15. Epub 2018 Jun 5.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, 64710, Monterrey, NL, Mexico.

Background: Translational research to develop pharmaceutical and surgical treatments for pterygium requires a reliable and easy to produce animal model. Extracellular matrix and fibroblast are important components of pterygium. The aim of this study was to analyze the effect of the subconjunctival injection of fibroblast cells (NIH3T3 cell line) and exogenous extracellular matrix in rabbits in producing a pterygium-like lesion. Read More

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http://dx.doi.org/10.1186/s40659-018-0165-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987467PMC
June 2018
17 Reads