12,432 results match your criteria Biological psychiatry[Journal]


The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder.

Biol Psychiatry 2019 Mar 7. Epub 2019 Mar 7.

Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut; Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, Connecticut.

Background: Autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are associated with complex changes as revealed by functional magnetic resonance imaging. To date, neuroimaging-based models are not able to characterize individuals with sufficient sensitivity and specificity. Further, although evidence shows that ADHD traits occur in individuals with autism spectrum disorder, and autism spectrum disorder traits in individuals with ADHD, the neurofunctional basis of the overlap is undefined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193014
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http://dx.doi.org/10.1016/j.biopsych.2019.02.019DOI Listing
March 2019
1 Read

Fear Extinction Retention: Is It What We Think It Is?

Biol Psychiatry 2019 Feb 19. Epub 2019 Feb 19.

Institute of Neurosciences, Hospital Clínic, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.

There has been an explosion of research on fear extinction in humans in the past 2 decades. This has not only generated major insights, but also brought a new goal into focus: how to maintain extinction memory over time (i.e. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.011DOI Listing
February 2019
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M Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder.

Biol Psychiatry 2019 Mar 7. Epub 2019 Mar 7.

Department of Pharmacology, Vanderbilt University, Nashville, Tennessee; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee. Electronic address:

Background: The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In psychiatric disorders such as posttraumatic stress disorder, PFC hyperactivity is associated with inappropriate fear in safe situations. We previously reported a form of muscarinic acetylcholine receptor (mAChR)-dependent long-term depression in the PFC that we hypothesize is involved in appropriate fear responding and could serve to reduce cortical hyperactivity following stress. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.020DOI Listing

Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults.

Biol Psychiatry 2019 Mar 1. Epub 2019 Mar 1.

Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam.

Background: Previous studies have reported associations between attention-deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first epigenome-wide association study meta-analysis of adult attention-deficit/hyperactivity disorder symptoms, based on peripheral blood DNA methylation (Infinium HumanMethylation450K array) in three population-based adult cohorts.

Methods: An epigenome-wide association study was performed in the Netherlands Twin Register (N = 2258, mean age 37 years), Dunedin Multidisciplinary Health and Development Study (N = 800, age 38 years), and Environmental Risk Longitudinal Twin Study (N = 1631, age 18 years), and results were combined through meta-analysis (total sample size N = 4689). Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.016DOI Listing

Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts.

Biol Psychiatry 2019 Mar 13. Epub 2019 Mar 13.

Department of Genetics, Stanford University School of Medicine, Stanford, California. Electronic address:

Background: Major depressive disorder (MDD) is moderately heritable, with a high prevalence and a presumed high heterogeneity. Copy number variants (CNVs) could contribute to the heritable component of risk, but the two previous genome-wide association studies of rare CNVs did not report significant findings.

Methods: In this meta-analysis of four cohorts (5780 patients and 6626 control subjects), we analyzed the association of MDD to 1) genome-wide burden of rare deletions and duplications, partitioned by length (<100 kb or >100 kb) and other characteristics, and 2) individual rare exonic CNVs and CNV regions. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.022DOI Listing
March 2019
3 Reads

Measuring Electroencephalography: The Ups and Downs of Delta and Beta Bands as Biomarkers for 15q11-q13-Related Disorders.

Biol Psychiatry 2019 May;85(9):e45-e46

Department of Neuroscience and the ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.03.002DOI Listing

Toward Precision Medicine: Prediction of Deep Brain Stimulation Targets of the Ventral Internal Capsule for Obsessive-Compulsive Disorder.

Authors:
Valerie Voon

Biol Psychiatry 2019 May;85(9):708-710

Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.03.969DOI Listing

Will Deep Brain Stimulation Help Move Precision Medicine to the Clinic in Psychiatry?

Biol Psychiatry 2019 May;85(9):706-707

Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193112
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http://dx.doi.org/10.1016/j.biopsych.2019.03.970DOI Listing
May 2019
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Chemogenetic Silencing of the Locus Coeruleus-Basolateral Amygdala Pathway Abolishes Pain-Induced Anxiety and Enhanced Aversive Learning in Rats.

Biol Psychiatry 2019 Mar 5. Epub 2019 Mar 5.

Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Institute of Health Carlos III, Madrid, Spain; Biomedical Research Foundation of Cadiz, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain; Neuropsychopharmacology and Psychobiology Research Group, Department of Psychology, University of Cádiz, Cádiz, Spain. Electronic address:

Background: Pain affects both sensory and emotional aversive responses, often provoking anxiety-related diseases when chronic. However, the neural mechanisms underlying the interactions between anxiety and chronic pain remain unclear.

Methods: We characterized the sensory, emotional, and cognitive consequences of neuropathic pain (chronic constriction injury) in a rat model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193012
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http://dx.doi.org/10.1016/j.biopsych.2019.02.018DOI Listing
March 2019
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Novel Machine Learning Identifies Brain Patterns Distinguishing Diagnostic Membership of Human Immunodeficiency Virus, Alcoholism, and Their Comorbidity of Individuals.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Mar 1. Epub 2019 Mar 1.

Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford, California; Center for Biomedical Sciences, SRI International, Menlo Park, California. Electronic address:

The incidence of alcohol use disorder (AUD) in human immunodeficiency virus (HIV) infection is twice that of the rest of the population. This study documents complex radiologically identified, neuroanatomical effects of AUD+HIV comorbidity by identifying structural brain systems that predicted diagnosis on an individual basis. Applying novel machine learning analysis to 549 participants (199 control subjects, 222 with AUD, 68 with HIV, 60 with AUD+HIV), 298 magnetic resonance imaging brain measurements were automatically reduced to small subsets per group. Read More

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http://dx.doi.org/10.1016/j.bpsc.2019.02.003DOI Listing
March 2019
2 Reads

Reduced Amygdala-Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Feb 4. Epub 2019 Feb 4.

Child Study Center, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

Background: Disruptive behaviors are prevalent in children with autism spectrum disorder (ASD) and often cause substantial impairments. However, the underlying neural mechanisms of disruptive behaviors remain poorly understood in ASD. In children without ASD, disruptive behavior is associated with amygdala hyperactivity and reduced connectivity with the ventrolateral prefrontal cortex (vlPFC). Read More

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http://dx.doi.org/10.1016/j.bpsc.2019.01.009DOI Listing
February 2019
1 Read

Changing Views on the Salience Network in Response to Data on Exposure to Assault.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Apr;4(4):331-332

Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519022193004
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http://dx.doi.org/10.1016/j.bpsc.2019.02.002DOI Listing
April 2019
2 Reads

Neural Markers That Distinguish Bipolar Disorder From Major Depressive Disorder: Moving Closer to a Reality.

Authors:
Mary L Phillips

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Apr;4(4):328-330

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2019.01.010DOI Listing
April 2019
1 Read

Nucleus Accumbens Cholinergic Interneurons Oppose Cue-Motivated Behavior.

Biol Psychiatry 2019 Feb 25. Epub 2019 Feb 25.

Department of Psychology, University of California, Los Angeles, Los Angeles, California; Brain Research Institute, University of California, Los Angeles, Los Angeles, California. Electronic address:

Background: Environmental reward-predictive stimuli provide a major source of motivation for adaptive reward pursuit behavior. This cue-motivated behavior is known to be mediated by the nucleus accumbens (NAc) core. The cholinergic interneurons in the NAc are tonically active and densely arborized and thus well suited to modulate NAc function. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.014DOI Listing
February 2019
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The Selective RhoA Inhibitor Rhosin Promotes Stress Resiliency Through Enhancing D1-Medium Spiny Neuron Plasticity and Reducing Hyperexcitability.

Biol Psychiatry 2019 Feb 13. Epub 2019 Feb 13.

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address:

Background: Nucleus accumbens dopamine 1 receptor medium spiny neurons (D1-MSNs) play a critical role in the development of depression-like behavior in mice. Social defeat stress causes dendritic morphological changes on this MSN subtype through expression and activation of early growth response 3 (EGR3) and the Rho guanosine triphosphatase RHOA. However, it is unknown how RhoA inhibition affects electrophysiological properties underlying stress-induced susceptibility. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.007DOI Listing
February 2019

Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional Behavior.

Biol Psychiatry 2019 Feb 13. Epub 2019 Feb 13.

The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois. Electronic address:

Background: The endocannabinoid and neurosteroid systems regulate emotions and stress responses. Activation of peroxisome proliferator-activated receptor (PPAR)-α by the endocannabinoid congener N-palmitoylethanolamine (PEA) regulates pathophysiological systems (e.g. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.006DOI Listing
February 2019
1 Read

Oxytocin Selectively Improves Empathic Accuracy: A Replication in Men and Novel Insights in Women.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Feb 13. Epub 2019 Feb 13.

Department of Family Medicine, McGill University, Montreal, Quebec, Canada.

Background: Previously, oxytocin, a neuropeptide implicated in human social cognition and behavior, was shown to improve people's ability to dynamically track another's emotional state ("empathic accuracy") specifically for less socially proficient individuals-i.e., healthy adults who score higher on the Autism Spectrum Quotient (AQ); conversely, oxytocin had no effect on empathic accuracy for more socially proficient individuals, who performed well following oxytocin and placebo. Read More

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http://dx.doi.org/10.1016/j.bpsc.2019.01.014DOI Listing
February 2019

Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder.

Biol Psychiatry 2019 Apr 3. Epub 2019 Apr 3.

Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Posttraumatic stress disorder (PTSD) is a stress disorder that develops in only some individuals following a traumatic event. Data suggest that a substantial fraction of women recover after sexual violence. Thus, the investigation of stress and antistress neuropeptides in this sample has the potential to inform the neurochemistry of resilience following trauma. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.017DOI Listing
April 2019
2 Reads

Decreased Amygdala Reactivity to Parent Cues Protects Against Anxiety Following Early Adversity: An Examination Across 3 Years.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, Columbia University, New York, New York.

Background: The human brain remains highly plastic for a protracted developmental period. Thus, although early caregiving adversities that alter amygdala development can result in enduring emotion regulation difficulties, these trajectories should respond to subsequent enriched caregiving. Exposure to high-quality parenting can regulate (i. Read More

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http://dx.doi.org/10.1016/j.bpsc.2019.02.001DOI Listing
February 2019
4 Reads

Functional Connectivity of Corticostriatal Circuitry and Psychosis-like Experiences in the General Community.

Biol Psychiatry 2019 Feb 21. Epub 2019 Feb 21.

Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia; School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia; Monash Biomedical Imaging, Monash University, Victoria, Australia.

Background: Psychotic symptoms are proposed to lie on a continuum, ranging from isolated psychosis-like experiences (PLEs) in nonclinical populations to frank disorder. Here, we investigated the neurobiological correlates of this continuum by examining whether functional connectivity of dorsal corticostriatal circuitry, which is disrupted in psychosis patients and individuals at high risk for psychosis, is associated with the severity of subclinical PLEs.

Methods: A community sample of 672 adults with no history of psychiatric or neurological illnesses completed a battery of seven questionnaires spanning various PLE domains. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193011
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http://dx.doi.org/10.1016/j.biopsych.2019.02.013DOI Listing
February 2019
2 Reads

Gender Trends in Authorship in Psychiatry Journals From 2008 to 2018.

Biol Psychiatry 2019 Feb 19. Epub 2019 Feb 19.

Center for Quantitative Health, Division of Clinical Research, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Women are currently underrepresented in academic psychiatry. As publication activity reflects both leadership and participation in academia, we examined temporal trends in women's authorship by conducting a large-scale bibliometric study of psychiatry journals.

Methods: We examined changes in proportions of women in the first, last, and overall authorship positions over time; relationship to journal impact factor and editorial board makeup; and rates of transition to senior author status using original research articles published in the 24 highest-impact psychiatry journals between January 2008 and May 2018. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.010DOI Listing
February 2019
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Odds and Risk Ratios: When They Are Similar and When They Are Not.

Biol Psychiatry 2019 Mar 26. Epub 2019 Mar 26.

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.12.024DOI Listing

Reply to: Odds and Risk Ratios: When They Are Similar and When They Are Not.

Biol Psychiatry 2019 Mar 26. Epub 2019 Mar 26.

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2019.02.012DOI Listing

Concurrent Use of Buprenorphine, Methadone, or Naltrexone Does Not Inhibit Ketamine's Antidepressant Activity.

Biol Psychiatry 2019 Mar 26. Epub 2019 Mar 26.

Department of Psychiatry, University of California, San Francisco, California; Weill Institute for Neurosciences, University of California, San Francisco, California; Mental Health Service, San Francisco VA Health Care System, San Francisco, California.

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http://dx.doi.org/10.1016/j.biopsych.2019.02.008DOI Listing
March 2019
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Advanced Paternal Age and Early Onset of Schizophrenia in Sporadic Cases: Not Confounded by Parental Polygenic Risk for Schizophrenia.

Biol Psychiatry 2019 Feb 7. Epub 2019 Feb 7.

Institute of Epidemiology and Preventive Medicine, College of Public Health, Taipei, Taiwan; Department of Public Health, College of Public Health, Taipei, Taiwan; Centers of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background: Whether paternal age effect on schizophrenia is a causation or just an association due to confounding by selection into late parenthood is still debated. We investigated the association between paternal age and early onset of schizophrenia in offspring, controlling for both paternal and maternal predisposition to schizophrenia as empirically estimated using polygenic risk score (PRS) derived from the Psychiatric Genomics Consortium.

Methods: Among 2923 sporadic schizophrenia cases selected from the Schizophrenia Trio Genomic Research in Taiwan project, 1649 had parents' genotyping data. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193006
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http://dx.doi.org/10.1016/j.biopsych.2019.01.023DOI Listing
February 2019
5 Reads

Erratum.

Authors:

Biol Psychiatry 2019 Apr;85(8):703

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http://dx.doi.org/10.1016/j.biopsych.2019.01.016DOI Listing

Connecting With Resilience.

Biol Psychiatry 2019 Apr;85(8):621-622

Department of Psychiatry, University of Vermont, Burlington, Vermont.

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http://dx.doi.org/10.1016/j.biopsych.2019.02.004DOI Listing

From Stress Sensitization to Microglial Priming and Vice Versa: A New Era of Research in Biological Psychiatry.

Authors:
Robert Dantzer

Biol Psychiatry 2019 Apr;85(8):619-620

Department of Symptom Research, Unit 1450, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.02.002DOI Listing

Histone Crotonylation Makes Its Mark in Depression Research.

Biol Psychiatry 2019 Apr;85(8):616-618

Department of Neuroscience, Friedman Brain Institute, New York, New York; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.01.025DOI Listing

Involvement in Sports, Hippocampal Volume, and Depressive Symptoms in Children.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Feb 4. Epub 2019 Feb 4.

Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri; Department of Radiology, Washington University in St. Louis, St. Louis, Missouri.

Background: Recent studies have found that higher levels of exercise are associated with fewer symptoms of depression among young people. In addition, research suggests that exercise may modify hippocampal volume, a brain region that has been found to show reduced volume in depression. However, it is not clear whether this relationship emerges as early as preadolescence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519022193002
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http://dx.doi.org/10.1016/j.bpsc.2019.01.011DOI Listing
February 2019
13 Reads

Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study.

Biol Psychiatry 2019 Jan 21. Epub 2019 Jan 21.

Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Institute of Genetic Medicine, University of Newcastle, Newcastle upon Tyne, United Kingdom.

Background: Exposure to early-life adversity is known to predict DNA methylation (DNAm) patterns that may be related to psychiatric risk. However, few studies have investigated whether adversity has time-dependent effects based on the age at exposure.

Methods: Using a two-stage structured life course modeling approach, we tested the hypothesis that there are sensitive periods when adversity induces greater DNAm changes. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.023DOI Listing
January 2019

Age-Normative Pathways of Striatal Connectivity Related to Clinical Symptoms in the General Population.

Biol Psychiatry 2019 Feb 6. Epub 2019 Feb 6.

Department of Psychiatry, Zucker Hillside Hospital, Northwell Health System, Glen Oaks, New York; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York; Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.

Background: Altered striatal development contributes to core deficits in motor and inhibitory control, impulsivity, and inattention associated with attention-deficit/hyperactivity disorder and may likewise play a role in deficient reward processing and emotion regulation in psychosis and depression. The maturation of striatal connectivity has not been well characterized, particularly as it relates to clinical symptomatology.

Methods: Resting-state functional connectivity with striatal subdivisions was examined for 926 participants (8-22 years of age, 44% male) from the general population who had participated in two large cross-sectional studies. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.01.024DOI Listing
February 2019
3 Reads

Neuroligin-2 Determines Inhibitory Synaptic Transmission in the Lateral Septum to Optimize Stress-Induced Neuronal Activation and Avoidance Behavior.

Biol Psychiatry 2019 Feb 4. Epub 2019 Feb 4.

Department of Cell Biology and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address:

Background: Investigations in the neocortex have revealed that the balance of excitatory and inhibitory synaptic transmission (E/I ratio) is important for proper information processing. The disturbance of this balance underlies many neuropsychiatric illnesses, including autism spectrum disorder and schizophrenia. However, little is known about the contribution of E/I balance to the functioning of subcortical brain regions, such as the lateral septum (LS), a structure that plays important roles in regulating anxiety-related behavior. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.01.022DOI Listing
February 2019

Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children.

Biol Psychiatry 2019 Jan 30. Epub 2019 Jan 30.

Institute of Food and Health, UCD School of Agriculture and Food Science, Dublin, Ireland.

Background: The identification of early biomarkers of psychotic experiences (PEs) is of interest because early diagnosis and treatment of those at risk of future disorder is associated with improved outcomes. The current study investigated early lipidomic and coagulation pathway protein signatures of later PEs in subjects from the Avon Longitudinal Study of Parents and Children cohort.

Methods: Plasma of 115 children (12 years of age) who were first identified as experiencing PEs at 18 years of age (48 cases and 67 controls) were assessed through integrated and targeted lipidomics and semitargeted proteomics approaches. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.01.018DOI Listing
January 2019

Glutamatergic System and Neuroimaging Studies of Treatment-Resistant Schizophrenia.

Biol Psychiatry 2019 Apr;85(7):e31-e32

Psychotic Disorders Division, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.02.003DOI Listing

Found in Translation: Autism Genetics and the Quest for Its Rosetta Stone.

Biol Psychiatry 2019 Apr;85(7):e29-e30

Division of Child and Adolescent Psychiatry, Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193007
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http://dx.doi.org/10.1016/j.biopsych.2019.02.001DOI Listing
April 2019
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Leveraging Human Induced Pluripotent Stem Cell-Based Models Provides Biological Context to Genome-wide Association Study Findings.

Biol Psychiatry 2019 Apr;85(7):532-533

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.01.021DOI Listing
April 2019
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The Up and Down of the N-Methyl-D-Aspartate Receptor That Causes Autism.

Biol Psychiatry 2019 Apr;85(7):530-531

Consiglio Nazionale delle Ricerche Neuroscience Institute and Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.01.020DOI Listing
April 2019
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Reply to: Microglia, Monocytes, and the Recurrence of Anxiety in Stress-Sensitized Mice.

Biol Psychiatry 2019 Mar 8. Epub 2019 Mar 8.

Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio; Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, Ohio; Division of Biosciences, The Ohio State University College of Dentistry, Columbus, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.01.026DOI Listing
March 2019
2 Reads

Microglia, Monocytes, and the Recurrence of Anxiety in Stress-Sensitized Mice.

Biol Psychiatry 2019 Mar 8. Epub 2019 Mar 8.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie und Centrum für Schlaganfallforschung Berlin, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.11.027DOI Listing

A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects.

Biol Psychiatry 2019 May 30;85(9):726-734. Epub 2019 Jan 30.

Department of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, United Kingdom; The National Hospital for Neurology and Neurosurgery, London, United Kingdom. Electronic address:

Background: Deep brain stimulation (DBS) is an emerging treatment for severe obsessive-compulsive disorder (OCD). We compared the efficacy of ventral capsule/ventral striatal (VC/VS) and anteromedial subthalamic nucleus (amSTN) DBS in the same patients and tested for mechanistic differences on mood and cognitive flexibility and associated neural circuitry. The possible synergistic benefit of DBS at both sites and cognitive behavioral therapy was explored. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193006
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http://dx.doi.org/10.1016/j.biopsych.2019.01.017DOI Listing
May 2019
8 Reads

Association Between Duration of Untreated Psychosis and Frontostriatal Connectivity During Maintenance of Visuospatial Working Memory.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Jan 30. Epub 2019 Jan 30.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

Background: A longer duration of untreated psychosis (DUP) has been linked with poor clinical outcomes and variation in resting-state striatal connectivity with central executive regions. However, the link between DUP and task-based activation of executive neurocognition has not previously been examined. This functional magnetic resonance imaging study examined the association between DUP and both activation and frontostriatal functional connectivity during a visual working memory (WM) paradigm in patients with first-episode psychosis. Read More

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http://dx.doi.org/10.1016/j.bpsc.2019.01.007DOI Listing
January 2019
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Micro- and Macrostructural White Matter Integrity in Never-Treated and Currently Unmedicated Patients With Schizophrenia and Effects of Short-Term Antipsychotic Treatment.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Jan 23. Epub 2019 Jan 23.

Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama.

Background: Schizophrenia is associated with progressive white matter changes, but it is unclear whether antipsychotic medications contribute to these. Our objective was to characterize effects of short-term treatment with risperidone on white matter diffusion indices.

Methods: We recruited 42 patients with schizophrenia (30 never treated and 12 currently untreated) and 42 matched healthy control subjects in this prospective case-control neuroimaging study. Read More

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http://dx.doi.org/10.1016/j.bpsc.2019.01.002DOI Listing
January 2019

Resting-State Functional Connectivity and Psychotic-like Experiences in Childhood: Results From the Adolescent Brain Cognitive Development Study.

Biol Psychiatry 2019 Jan 26. Epub 2019 Jan 26.

Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri; Department of Radiology, Washington University School of Medicine in St Louis, St. Louis, Missouri; Department of Psychology, Washington University in St. Louis, St. Louis, Missouri.

Background: Psychotic-like experiences (PLEs) during childhood are associated with greater risk of developing a psychotic disorder (and other mental disorders), highlighting the importance of identifying neural correlates of childhood PLEs. Three major cortical networks-the cingulo-opercular network (CON), default mode network (DMN), and frontoparietal network-are consistently implicated in psychosis and PLEs in adults. However, it is unclear whether variation in functional connectivity is associated with PLEs in school-aged children. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.01.013DOI Listing
January 2019
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Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence.

Biol Psychiatry 2019 Jan 30. Epub 2019 Jan 30.

Norwegian Centre for Mental Disorders Research, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway.

Background: Accumulating evidence supports cerebellar involvement in mental disorders, such as schizophrenia, bipolar disorder, depression, anxiety disorders, and attention-deficit/hyperactivity disorder. However, little is known about the cerebellum in developmental stages of these disorders. In particular, whether cerebellar morphology is associated with early expression of specific symptom domains remains unclear. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.01.019DOI Listing
January 2019
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Subcortical Shape Abnormalities in Bulimia Nervosa.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Jan 4. Epub 2019 Jan 4.

Division of Child and Adolescent Psychiatry, Columbia University Medical Center and the New York State Psychiatric Institute, New York, New York.

Background: Bulimia nervosa (BN) is associated with functional abnormalities in frontostriatal and frontolimbic circuits. Although structural alterations in the frontal portions of these circuits have been observed, this is the first study of subcortical surface morphometry and the largest study of subcortical volume in BN.

Methods: Anatomical magnetic resonance scans were acquired from 62 female participants with full and subthreshold BN (mean age ± SD, 18. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519022183033
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http://dx.doi.org/10.1016/j.bpsc.2018.12.011DOI Listing
January 2019
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Amygdala-Hippocampal Connectivity Is Associated With Endogenous Levels of Oxytocin and Can Be Altered by Exogenously Administered Oxytocin in Adults With Autism.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Feb 4. Epub 2019 Feb 4.

Department of Health Sciences and Technology, Neural Control of Movement Lab, Eidgenössische Technische Hochschule, Zurich, Switzerland.

Background: Oxytocin (OT) plays a pivotal role in interpersonal bonding, affiliation, and trust, and its intranasal administration is increasingly considered as a potential treatment for autism spectrum disorder.

Methods: We explored whether variations in endogenous salivary OT concentration are related to interindividual differences in core autism symptoms and expressions of attachment in 38 male adults with autism spectrum disorder. Further, resting-state functional magnetic resonance imaging was adopted to specifically explore whether interindividual differences are reflected in the intrinsic network organization of key regions of the central oxytocinergic system. Read More

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http://dx.doi.org/10.1016/j.bpsc.2019.01.008DOI Listing
February 2019
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Synapse-to-Nucleus Signaling in Neurodegenerative and Neuropsychiatric Disorders.

Biol Psychiatry 2019 Jan 17. Epub 2019 Jan 17.

Institut de Neurociències, Department de Bioquímica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

Synapse-to-nucleus signaling is critical for converting signals received at synapses into transcriptional programs essential for cognition, memory, and emotion. This neuronal mechanism usually involves activity-dependent translocation of synaptonuclear factors from synapses to the nucleus resulting in regulation of transcriptional programs underlying synaptic plasticity. Acting as synapse-to-nucleus messengers, amyloid precursor protein intracellular domain associated-1 protein, cAMP response element binding protein (CREB)-regulated transcription coactivator-1, Jacob, nuclear factor kappa-light-chain-enhancer of activated B cells, RING finger protein 10, and SH3 and multiple ankyrin repeat domains 3 play essential roles in synapse remodeling and plasticity, which are considered the cellular basis of memory. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193003
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http://dx.doi.org/10.1016/j.biopsych.2019.01.006DOI Listing
January 2019
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Incubation of Cocaine Craving After Intermittent Access Self-administration: Sex Differences and Estrous Cycle.

Biol Psychiatry 2019 Jan 29. Epub 2019 Jan 29.

Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland. Electronic address:

Background: Studies using continuous-access drug self-administration showed that cocaine seeking increases during abstinence (incubation of cocaine craving). Recently, studies using intermittent-access self-administration showed increased motivation to self-administer and seek cocaine. We examined whether intermittent cocaine self-administration would potentiate incubation of craving in male and female rats and examined the estrous cycle's role in this incubation. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.01.015DOI Listing
January 2019