12,362 results match your criteria Biological psychiatry[Journal]


Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youths on the Psychosis Spectrum.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Dec 27. Epub 2018 Dec 27.

Department of Psychology, University of California, Los Angeles, Los Angeles, California. Electronic address:

Background: Psychosis onset typically occurs in adolescence, and subclinical psychotic experiences peak in adolescence. Adolescence is also a time of critical neural and cognitive maturation. Using cross-sectional data from the Philadelphia Neurodevelopmental Cohort, we examined whether regional white matter (WM) development is disrupted in youths with psychosis spectrum (PS) features and whether WM maturation mediates the relationship between age and cognition in typically developing (TD) youths and youths with PS features. Read More

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http://dx.doi.org/10.1016/j.bpsc.2018.12.008DOI Listing
December 2018

Accelerated Aging of Functional Brain Networks Supporting Cognitive Function in Psychotic Disorders.

Biol Psychiatry 2019 Jan 4. Epub 2019 Jan 4.

Department of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee.

Background: Across networks, connectivity within the frontoparietal network (FPN) and cingulo-opercular network (CON) exhibits reductions earliest during healthy aging, contributing to cognitive impairment. Individuals with psychotic disorders demonstrate evidence of accelerated aging across multiple biological systems. By leveraging a large sample of patients with psychosis from early to chronic illness stages, this study sought to determine whether the CON and FPN exhibit evidence of accelerated aging in psychotic disorders, confirm associations between network efficiency and cognition, and determine whether reduced network efficiency is observed in early-stage psychosis. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.016DOI Listing
January 2019
1 Read

Model-Free and Model-Based Influences in Addiction-Related Behaviors.

Biol Psychiatry 2019 Jan 4. Epub 2019 Jan 4.

Department of Psychiatry, Yale University, New Haven, Connecticut; Department of Psychology, Yale University, New Haven, Connecticut. Electronic address:

Background: Disruptions in the decision-making processes that guide action selection are a core feature of many psychiatric disorders, including addiction. Decision making is influenced by the goal-directed and habitual systems that can be computationally characterized using model-based and model-free reinforcement learning algorithms, respectively. Recent evidence suggests an imbalance in the influence of these reinforcement learning systems on behavior in individuals with substance dependence, but it is unknown whether these disruptions are a manifestation of chronic drug use and/or are a preexisting risk factor for addiction. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.017DOI Listing
January 2019
1 Read

Predicting Polygenic Risk of Psychiatric Disorders.

Biol Psychiatry 2018 Dec 28. Epub 2018 Dec 28.

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts.

Genetics provides two major opportunities for understanding human disease-as a transformative line of etiological inquiry and as a biomarker for heritable diseases. In psychiatry, biomarkers are very much needed for both research and treatment, given the heterogenous populations identified by current phenomenologically based diagnostic systems. To date, however, useful and valid biomarkers have been scant owing to the inaccessibility and complexity of human brain tissue and consequent lack of insight into disease mechanisms. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.015DOI Listing
December 2018

Chronic Stress Causes Projection-Specific Adaptation of Amygdala Neurons via Small-Conductance Calcium-Activated Potassium Channel Downregulation.

Biol Psychiatry 2018 Dec 20. Epub 2018 Dec 20.

Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, China; Department of Neurology, Second Affiliated Hospital, Nanchang University, Nanchang, China. Electronic address:

Background: The role of the amygdala in mediating stress coping has been long appreciated. However, basolateral amygdala (BLA) projection neurons (PNs) are organized into discrete output circuits, and it remains unclear whether stress differentially impacts these circuits.

Methods: Mice were exposed to acute restraint stress or chronic restraint stress (CRS), and c-fos expression was measured as a proxy for neuronal activation in Retrobead retrogradely labeled dorsomedial prefrontal cortex-targeting PNs (BLA→dmPFC) and non-dmPFC-targeting PNs (BLA↛dmPFC). Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.010DOI Listing
December 2018
1 Read

Understanding Personal Control and the Brain Reward System for Psychopathology Is Challenging but Important.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Feb;4(2):105-107

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Center for Depression, Anxiety and Stress Research, Belmont, Massachusetts; McLean Imaging Center, McLean Hospital, Belmont, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377248PMC
February 2019

Finding the Neural Basis of Pediatric Posttraumatic Stress Disorder.

Authors:
Joel Stoddard

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Feb;4(2):103-104

Pediatric Mental Health Institute, Department of Psychiatry, School of Medicine, University of Colorado, Aurora, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2018.12.009DOI Listing
February 2019
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Two Methodologies in "Amygdala Activation and Connectivity to Emotional Processing Distinguishes Asymptomatic Patients With Bipolar Disorders and Unipolar Depression" That Can Produce False-Positive Results and Some Statistical Recommendations.

Authors:
Simon N Vandekar

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Feb 4. Epub 2019 Feb 4.

Department of Biostatistics, Vanderbilt University, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2018.12.007DOI Listing
February 2019

Reply to: Two Methodologies in "Amygdala Activation and Connectivity to Emotional Processing Distinguishes Asymptomatic Patients With Bipolar Disorders and Unipolar Depression" That Can Produce False-Positive Results and Some Statistical Recommendations.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Feb 4. Epub 2019 Feb 4.

Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead; and Discipline of Psychiatry, University of Sydney School of Medicine, Sydney, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2018.12.006DOI Listing
February 2019

Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability.

Biol Psychiatry 2018 Dec 27. Epub 2018 Dec 27.

Institute for Neuroscience and Department of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC. Electronic address:

Background: The prevalence of neurodevelopmental disorders is biased toward male individuals, with male-to-female ratios of 2:1 in intellectual disability and 4:1 in autism spectrum disorder. However, the molecular mechanisms of such bias remain unknown. While characterizing a mouse model for loss of the signaling scaffold coiled-coil and C2 domain-containing protein 1A (CC2D1A), which is mutated in intellectual disability and autism spectrum disorder, we identified biochemical and behavioral differences between male and female mice, and explored whether CC2D1A controls male-specific intracellular signaling. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.013DOI Listing
December 2018
1 Read

Erratum.

Authors:

Biol Psychiatry 2019 Mar;85(5):434

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http://dx.doi.org/10.1016/j.biopsych.2019.01.003DOI Listing

Erratum.

Authors:

Biol Psychiatry 2019 Mar;85(5):434

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http://dx.doi.org/10.1016/j.biopsych.2019.01.005DOI Listing

Erratum.

Authors:

Biol Psychiatry 2019 Mar;85(5):434

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http://dx.doi.org/10.1016/j.biopsych.2019.01.004DOI Listing

Connections With Connections: Dopaminergic Correlates of Neural Network Properties.

Biol Psychiatry 2019 Mar;85(5):366-367

Clinical and Translational Neuroscience Branch, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.01.001DOI Listing

MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease.

Biol Psychiatry 2018 Dec 19. Epub 2018 Dec 19.

Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China; National Research Center for Geriatric Diseases, Xiangya Hospital, and Center for Medical Genetics, School of Life Science, Central South University, Changsha, Hunan, China. Electronic address:

Background: Death-associated protein kinase 1 (DAPK1) is a widely distributed serine/threonine kinase that is critical for cell death in multiple neurological disorders, including Alzheimer's disease and stroke. However, little is known about the role of DAPK1 in the pathogenesis of Parkinson's disease (PD), the second most common neurodegenerative disorder.

Methods: We used Western blot and immunohistochemistry to evaluate the alteration of DAPK1. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.008DOI Listing
December 2018
2 Reads

Pretreatment Rostral Anterior Cingulate Cortex Connectivity With Salience Network Predicts Depression Recovery: Findings From the EMBARC Randomized Clinical Trial.

Biol Psychiatry 2018 Dec 19. Epub 2018 Dec 19.

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts. Electronic address:

Background: Baseline rostral anterior cingulate cortex (rACC) activity is a well-replicated nonspecific predictor of depression improvement. The rACC is a key hub of the default mode network, which prior studies indicate is hyperactive in major depressive disorder. Because default mode network downregulation is reliant on input from the salience network and frontoparietal network, an important question is whether rACC connectivity with these systems contributes to depression improvement. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.007DOI Listing
December 2018

Neurotrophic and Antidepressant Actions of Brain-Derived Neurotrophic Factor Require Vascular Endothelial Growth Factor.

Biol Psychiatry 2018 Dec 27. Epub 2018 Dec 27.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

Background: Activity-dependent release of brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex (mPFC) is essential for the rapid and sustained antidepressant actions of ketamine, and a recent study shows a similar requirement for vascular endothelial growth factor (VEGF). Since BDNF is reported to stimulate VEGF expression and/or release in neuroblastoma cells, the present study tested the hypothesis that the actions of BDNF are mediated by VEGF.

Methods: The role of VEGF in the antidepressant behavioral actions of BDNF was tested by intra-mPFC coinfusion of a VEGF neutralizing antibody and by neuron-specific deletion of VEGF. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.014DOI Listing
December 2018
2 Reads

Alcohol Expectancy and Cerebral Responses to Cue-Elicited Craving in Adult Nondependent Drinkers.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut. Electronic address:

Background: Positive alcohol expectancy (AE) contributes to excessive drinking. Many imaging studies have examined cerebral responses to alcohol cues and how these regional processes related to problem drinking. However, it remains unclear how AE relates to cue response and whether AE mediates the relationship between cue response and problem drinking. Read More

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http://dx.doi.org/10.1016/j.bpsc.2018.11.012DOI Listing
December 2018

Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Dec 5. Epub 2018 Dec 5.

Department of Cognitive Neuroscience, Radboud University Medical Center, the Netherlands; Donders Institute for Brain, Cognition, and Behavior, Radboud University, the Netherlands; Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, the Netherlands.

Background: Resting-state functional magnetic resonance imaging-based studies on functional connectivity in autism spectrum disorder (ASD) have generated inconsistent results. Interpretation of findings is further hampered by small samples and a focus on a limited number of networks, with networks underlying sensory processing being largely underexamined. We aimed to comprehensively characterize ASD-related alterations within and between 20 well-characterized resting-state networks using baseline data from the EU-AIMS (European Autism Interventions-A Multicentre Study for Developing New Medications) Longitudinal European Autism Project. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519022183030
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http://dx.doi.org/10.1016/j.bpsc.2018.11.010DOI Listing
December 2018
2 Reads

Hyperperfusion of Frontal White and Subcortical Gray Matter in Autism Spectrum Disorder.

Biol Psychiatry 2018 Dec 21. Epub 2018 Dec 21.

Institute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, California; Keck School of Medicine, University of Southern California, Los Angeles, California.

Background: Our aim was to assess resting cerebral blood flow (rCBF) in children and adults with autism spectrum disorder (ASD).

Methods: We acquired pulsed arterial spin labeling magnetic resonance imaging data in 44 generally high-functioning participants with ASD simplex and 66 typically developing control subjects with comparable mean full-scale IQs. We compared rCBF values voxelwise across diagnostic groups and assessed correlations with symptom scores. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223183209
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http://dx.doi.org/10.1016/j.biopsych.2018.11.026DOI Listing
December 2018
11 Reads

Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen-Level Dependent Functional Magnetic Resonance Imaging.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, University of California, San Diego, La Jolla, California; Department of Neurosciences, University of California, San Diego, La Jolla, California; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown.

Background: Functional magnetic resonance imaging (fMRI) in awake behaving mice is well positioned to bridge the detailed cellular-level view of brain activity, which has become available owing to recent advances in microscopic optical imaging and genetics, to the macroscopic scale of human noninvasive observables. However, though microscopic (e.g. Read More

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http://dx.doi.org/10.1016/j.bpsc.2018.12.002DOI Listing
December 2018

Dynamic Causal Modeling of Insular, Striatal, and Prefrontal Cortex Activities During a Food-Specific Go/NoGo Task.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Jan 4. Epub 2019 Jan 4.

Brain and Creativity Institute, University of Southern California, Los Angeles, California; Department of Psychology, University of Southern California, Los Angeles, California.

Background: This study aimed to investigate the dynamic interactions among three neural systems that are implicated in substance and behavioral addictions in response to food cues in young adults. These include an impulsive system involving the striatum, a reflective system involving the prefrontal cortex, and a homeostasis sensing system involving the insular cortex.

Methods: College students (N = 45) with various levels of body mass index were recruited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519022183032
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http://dx.doi.org/10.1016/j.bpsc.2018.12.005DOI Listing
January 2019
3 Reads

Insula Functional Connectivity in Schizophrenia: Subregions, Gradients, and Symptoms.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Dec 13. Epub 2018 Dec 13.

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia; Centre for Neural Engineering, The University of Melbourne, Parkville, Victoria, Australia; Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia; Cooperative Research Centre for Mental Health, Carlton, Victoria, Australia.

Background: The insular cortex is connected to a diverse network of cortical and subcortical areas. This study aimed to investigate whether the diversity in functional connectivity across the insula's topography is altered in individuals with schizophrenia and relates to the clinical symptoms of the disorder.

Methods: Insula-to-whole-brain functional connectivity was mapped using resting-state functional magnetic resonance imaging at the resolution of voxels in individuals with schizophrenia (n = 49) and healthy comparison individuals (n = 52). Read More

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http://dx.doi.org/10.1016/j.bpsc.2018.12.003DOI Listing
December 2018

Specific Substantial Dysconnectivity in Schizophrenia: A Transdiagnostic Multimodal Meta-analysis of Resting-State Functional and Structural Magnetic Resonance Imaging Studies.

Biol Psychiatry 2018 Dec 11. Epub 2018 Dec 11.

Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Neuroimaging Center at the Technische Universität München, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Department of Psychiatry, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Background: This study investigated characteristic large-scale brain changes in schizophrenia. Numerous imaging studies have demonstrated brain changes in schizophrenia, particularly aberrant intrinsic functional connectivity (iFC) of ongoing brain activity, measured by resting-state functional magnetic resonance imaging, and aberrant gray matter volume (GMV) of distributed brain regions, measured by structural magnetic resonance imaging. It is unclear, however, which iFC changes are specific to schizophrenia compared with those of other disorders and whether such specific iFC changes converge with GMV changes. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.003DOI Listing
December 2018
2 Reads

Alterations in Systemic and Cognitive Glucocorticoid Sensitivity in Depression.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Dec 4. Epub 2018 Dec 4.

Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin. Electronic address:

Background: Decades of research point to cortisol insensitivity as a biomarker of depression. Despite a vast literature on cortisol's effects on memory, the role of cortisol insensitivity in core psychological features of depression, such as emotional memory biases, is unknown.

Methods: Sixty-five premenopausal women with varying levels of depression completed this study involving an at-home low-dose dexamethasone suppression test and four experimental sessions (i. Read More

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http://dx.doi.org/10.1016/j.bpsc.2018.11.007DOI Listing
December 2018

Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases.

Biol Psychiatry 2018 Dec 20. Epub 2018 Dec 20.

Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, New York, New York.

Background: Genetic risk for bipolar disorder (BD) is conferred through many common alleles, while a role for rare copy number variants (CNVs) is less clear. Subtypes of BD including schizoaffective disorder bipolar type (SAB), bipolar I disorder (BD I), and bipolar II disorder (BD II) differ according to the prominence and timing of psychosis, mania, and depression. The genetic factors contributing to the combination of symptoms among these subtypes are poorly understood. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.009DOI Listing
December 2018
1 Read
10.255 Impact Factor

Impaired Expected Value Computations in Schizophrenia Are Associated With a Reduced Ability to Integrate Reward Probability and Magnitude of Recent Outcomes.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Dec 7. Epub 2018 Dec 7.

Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland.

Background: Motivational deficits in people with schizophrenia (PSZ) are associated with an inability to integrate the magnitude and probability of previous outcomes. The mechanisms that underlie probability-magnitude integration deficits, however, are poorly understood. We hypothesized that increased reliance on "valueless" stimulus-response associations, in lieu of expected value (EV)-based learning, could drive probability-magnitude integration deficits in PSZ with motivational deficits. Read More

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http://dx.doi.org/10.1016/j.bpsc.2018.11.011DOI Listing
December 2018

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.

Biol Psychiatry 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, University of Minnesota, Minneapolis, Minnesota. Electronic address:

Background: Smoking and alcohol use have been associated with common genetic variants in multiple loci. Rare variants within these loci hold promise in the identification of biological mechanisms in substance use. Exome arrays and genotype imputation can now efficiently genotype rare nonsynonymous and loss of function variants. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.11.024DOI Listing
December 2018
1 Read
10.255 Impact Factor

Subgenual Functional Connectivity Predicts Antidepressant Treatment Response to Transcranial Magnetic Stimulation: Independent Validation and Evaluation of Personalization.

Biol Psychiatry 2019 Jan 19. Epub 2019 Jan 19.

Monash Alfred Psychiatry Research Centre, Monash University, Melbourne, Victoria; Epworth HealthCare, Epworth Clinic, Camberwell, Victoria, Australia.

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http://dx.doi.org/10.1016/j.biopsych.2018.12.002DOI Listing
January 2019

Chromodomain Y-like Protein-Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors.

Biol Psychiatry 2018 Dec 5. Epub 2018 Dec 5.

State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Beijing, China; Key Laboratory for Neuroscience, Ministry of Education and National Health Commission, Beijing, China. Electronic address:

Background: Major depressive disorder is a prevalent and life-threatening illness in modern society. The susceptibility to major depressive disorder is profoundly influenced by environmental factors, such as stressful lifestyle or traumatic events, which could impose maladaptive transcriptional program through epigenetic regulation. However, the underlying molecular mechanisms remain elusive. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.11.025DOI Listing
December 2018
2 Reads

Early Caregiving Intervention Holds Promise for Long-term Improvements in Neural Function Following Adversity.

Biol Psychiatry 2019 Feb;85(4):e15-e16

Department of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.12.005DOI Listing
February 2019

Interpreting New Evidence on Prenatal Infections and Mental Disorders.

Biol Psychiatry 2019 Feb;85(4):285-286

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York.

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http://dx.doi.org/10.1016/j.biopsych.2018.12.004DOI Listing
February 2019

DISC1 and Its Protein Interactomes for Mental Function.

Authors:
Akira Sawa

Biol Psychiatry 2019 Feb;85(4):283-284

Departments of Psychiatry, Neuroscience, Mental Health, and Biomedical Engineering, Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.12.011DOI Listing
February 2019

Common (Genetic) Links Between Clinics and the Community: New Evidence From a Tourette Syndrome Polygenic Score.

Authors:
Angelica Ronald

Biol Psychiatry 2019 Feb;85(4):281-282

Department of Psychological Sciences, Centre for Brain and Cognitive Development, University of London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.12.006DOI Listing
February 2019

Sex-Specific Regulation of Fear Memory by Targeted Epigenetic Editing of Cdk5.

Biol Psychiatry 2018 Dec 5. Epub 2018 Dec 5.

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Sex differences in the expression and prevalence of trauma- and stress-related disorders have led to a growing interest in the sex-specific molecular and epigenetic mechanisms underlying these diseases. Cyclin-dependent kinase 5 (CDK5) is known to underlie both fear memory and stress behavior in male mice. Given our recent finding that targeted histone acetylation of Cdk5 regulates stress responsivity in male mice, we hypothesized that such a mechanism may be functionally relevant in female mice as well. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.11.022DOI Listing
December 2018
3 Reads

Variations in Hippocampal White Matter Diffusivity Differentiate Response to Electroconvulsive Therapy in Major Depression.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Nov 14. Epub 2018 Nov 14.

Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California, Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California. Electronic address:

Background: Electroconvulsive therapy (ECT) is an effective treatment for severe depression and is shown to increase hippocampal volume and modulate hippocampal functional connectivity. Whether variations in hippocampal structural connectivity occur with ECT and relate to clinical response is unknown.

Methods: Patients with major depression (n = 36, 20 women, age 41. Read More

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http://dx.doi.org/10.1016/j.bpsc.2018.11.003DOI Listing
November 2018
2 Reads

Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories.

Biol Psychiatry 2018 Dec 19. Epub 2018 Dec 19.

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; Center for Information and Neural Networks, National Institute of Information and Communications Technology, Osaka, Japan.

Background: A method that promotes the retrieval of lost long-term memories has not been well established. Histamine in the central nervous system is implicated in learning and memory, and treatment with antihistamines impairs learning and memory. Because histamine H receptor inverse agonists upregulate histamine release, the inverse agonists may enhance learning and memory. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223183202
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http://dx.doi.org/10.1016/j.biopsych.2018.11.009DOI Listing
December 2018
14 Reads

From Structure to Behavior: Circuit Specificity of Stress-Induced Synaptic Plasticity in the Basolateral Amygdala Projection Neurons.

Authors:
Giulia Treccani

Biol Psychiatry 2019 Feb;85(3):e7-e9

Department of Psychiatry and Psychotherapy, Focus Program Translational Neurosciences, and German Resilience Center, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany, and the Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.11.017DOI Listing
February 2019
1 Read

The Parable of Panic: Suffocation, Social Attachment, and the Critical Role of an Integrative, Biopsychosocial Formulation.

Biol Psychiatry 2019 Feb;85(3):e5-e6

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.biopsych.2018.11.023DOI Listing
February 2019
1 Read

Biological Signatures of Brain Aging and Accelerated Aging by Early Life Threat.

Authors:
Carmen Sandi

Biol Psychiatry 2019 Feb;85(3):187-188

Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.11.020DOI Listing
February 2019
1 Read

Extinction Versus Epigenetic Intergenerational Inheritance: Who Wins?

Biol Psychiatry 2019 Feb;85(3):184-186

Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, Center for Addiction Neuroscience, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063223183204
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http://dx.doi.org/10.1016/j.biopsych.2018.11.016DOI Listing
February 2019
4 Reads

Diffusion Tensor Imaging Analysis of Mild Traumatic Brain Injury and Posttraumatic Stress Disorder.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Jan 29;4(1):81-90. Epub 2018 Oct 29.

School of Psychology, University of New South Wales, Sydney, Australia; Brain Dynamics Centre, Westmead Institute for Medical Research, Westmead, Australia. Electronic address:

Background: Debate exists over the extent to which dysfunctions arising from mild traumatic brain injury (mTBI) are distinct from posttraumatic stress disorder (PTSD).

Methods: This study investigated 1) the white matter integrity of participants with either mTBI or PTSD, and 2) the relationship between white matter integrity and postconcussive syndrome. The sample comprised 110 civilians (mTBI group = 40; PTSD group = 32; age- and sex-matched trauma-exposed control subjects = 38) recruited from community advertising. Read More

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http://dx.doi.org/10.1016/j.bpsc.2018.10.004DOI Listing
January 2019
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Toward Understanding Developmental Disruption of Default Mode Network Connectivity Due to Early Life Stress.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Jan;4(1):5-7

Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519022183030
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http://dx.doi.org/10.1016/j.bpsc.2018.11.008DOI Listing
January 2019
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Early Variations in Amygdala Development May Signal Divergent Behavioral Outcomes.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Jan;4(1):3-4

The MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, California.

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http://dx.doi.org/10.1016/j.bpsc.2018.11.009DOI Listing
January 2019
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Common Dysfunction of Large-Scale Neurocognitive Networks Across Psychiatric Disorders.

Biol Psychiatry 2019 Mar 23;85(5):379-388. Epub 2018 Nov 23.

National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China. Electronic address:

Background: Cognitive dysfunction is one of the most prominent characteristics of psychiatric disorders. Currently, the neural correlates of cognitive dysfunction across psychiatric disorders are poorly understood. The aim of this study was to investigate functional connectivity and structural perturbations across psychiatric diagnoses in three neurocognitive networks of interest: the default mode network (DMN), the frontoparietal network (FPN), and the salience network (SN). Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.11.011DOI Listing
March 2019
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Lack of Diagnostic Utility of "Amino Acid Dysregulation Metabotypes".

Biol Psychiatry 2018 Dec 27. Epub 2018 Dec 27.

Division of Epidemiology, Department of Health Research and Policy, Stanford University, Stanford, California. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.11.012DOI Listing
December 2018
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Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.

Biol Psychiatry 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.

Background: Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.11.010DOI Listing
November 2018
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Reply to: Lack of Diagnostic Utility of "Amino Acid Dysregulation Metabotypes".

Biol Psychiatry 2018 Dec 27. Epub 2018 Dec 27.

Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, Davis, California; Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.11.013DOI Listing
December 2018
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Neural Indicators of Anhedonia: Predictors and Mechanisms of Treatment Change in a Randomized Clinical Trial in Early Childhood Depression.

Biol Psychiatry 2018 Dec 4. Epub 2018 Dec 4.

Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.

Background: Early childhood depression is associated with anhedonia and reduced event-related potential (ERP) responses to rewarding or pleasant stimuli. Whether these neural measures are indicators of target engagement or treatment outcome is not yet known.

Methods: We measured ERP responses to win and loss feedback in a guessing task and to pleasant versus neutral pictures in young (4. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.11.021DOI Listing
December 2018
4 Reads