798 results match your criteria Biological Research For Nursing [Journal]


Potential Role of the Gut Microbiome in ALS: A Systematic Review.

Biol Res Nurs 2018 Jan 1:1099800418784202. Epub 2018 Jan 1.

1 Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.

Amyotrophic lateral sclerosis (ALS) etiology and pathophysiology are not well understood. Recent data suggest that dysbiosis of gut microbiota may contribute to ALS etiology and progression. This review aims to explore evidence of associations between gut microbiota and ALS etiology and pathophysiology. Read More

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January 2018

Dose of Early Therapeutic Mobility: Does Frequency or Intensity Matter?

Biol Res Nurs 2018 Jan 1:1099800418780492. Epub 2018 Jan 1.

8 Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Objective: Investigate the feasibility of a nurse-led mobility protocol and compare the effects of once- versus twice-daily episodes of early therapeutic mobility (ETM) and low- versus moderate-intensity ETM on serum biomarkers of inflammation and selected outcomes in critically ill adults.

Design: Randomized interventional study with repeated measures and blinded assessment of outcomes.

Setting: Four adult intensive care units (ICUs) in two academic medical centers. Read More

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January 2018
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Associations Between Secondhand Tobacco Smoke Exposure and Nicotine Dependence and Smoking Cessation Attempts Among Adult Tobacco Users With a Psychiatric Disorder.

Biol Res Nurs 2018 Jan 1:1099800418781914. Epub 2018 Jan 1.

1 University of Kentucky College of Nursing, Lexington, KY, USA.

Introduction: Secondhand smoke exposure (SHSe) is predictive of greater nicotine dependence (ND) and poor smoking cessation (SC) outcomes. SHSe and its impact on ND and SC attempts in people with psychiatric disorders (PD) remain poorly understood. Hence, the objectives of this study were to (1) quantify SHSe, (2) examine the association of SHSe with ND, and (3) assess the association between SHSe and SC among tobacco users with PD. Read More

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January 2018
1 Read

Chronic Stress in Children and Adolescents: A Review of Biomarkers for Use in Pediatric Research.

Authors:
Eileen M Condon

Biol Res Nurs 2018 Jan 1:1099800418779214. Epub 2018 Jan 1.

1 Yale School of Nursing, West Campus Drive, Orange, CT, USA.

Problem: Incorporating biomarkers of chronic stress into pediatric research studies may help to explicate the links between exposure to adversity and lifelong health, but there are currently very few parameters to guide nurse researchers in choosing appropriate biomarkers of chronic stress for use in research with children and adolescents.

Methods: Biomarkers of chronic stress are described, including primary mediators (glucocorticoids, catecholamines, and cytokines) and secondary outcomes (neurologic, immune, metabolic, cardiovascular, respiratory, and anthropometric) of the chronic stress response.

Results: Evidence of the use of each biomarker in pediatric research studies is reviewed. Read More

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January 2018

Eating Behavior, Stress, and Adiposity: Discordance Between Perception and Physiology.

Biol Res Nurs 2018 Jan 1:1099800418779460. Epub 2018 Jan 1.

2 Digestive Disorders Unit, Division of Intramural Research, Department of Health and Human Services (DHHS), National Institute of Nursing Research (NINR), National Institutes of Health (NIH), Bethesda, MD, USA.

The purpose of the study was to examine the interrelationships among stress, eating behavior, and adiposity in a cohort of normal- and overweight individuals. Clinical markers of physiological stress (fasting serum cortisol) and adiposity (body mass index [BMI] and percent body fat) were obtained from participants selected for a natural history protocol ( n = 107). Self-reported data on eating behavior (using the Three-Factor Eating Questionnaire subscales such as Cognitive Restraint, Disinhibition, and Hunger) and psychological stress (via the Perceived Stress Scale) were evaluated. Read More

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January 2018

Biological Sex Differences in Depression: A Systematic Review.

Biol Res Nurs 2018 Jul 14;20(4):383-392. Epub 2018 May 14.

1 Department of Basic Psychological Processes and their Development, University of the Basque Country, San Sebastián, Spain.

Depression is the leading cause of disability worldwide, and its prevalence is 2 times higher in women than in men. There is, however, a lack of data on sex-specific pathophysiology of this disorder. The purpose of this systematic review is to identify the biological sex differences found in major depressive disorder (MDD) in studies published in the last 10 years. Read More

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July 2018
1 Read

Impact of Positive Pressure Treatment of the Airway on Health-Related Quality of Life in Elderly Patients With Obstructive Sleep Apnea.

Biol Res Nurs 2018 Jul 3;20(4):452-461. Epub 2018 May 3.

1 Sleep Unit, Respiratory Department, University Hospital Reina Sofia, Córdoba, Spain.

Background: Obstructive sleep apnea (OSA) is a chronic illness that increases in prevalence with age. Treatment includes continuous positive airway pressure (CPAP) devices. Studies about the use of CPAP in the elderly are scarce. Read More

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Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment.

Biol Res Nurs 2018 Jul 1;20(4):403-409. Epub 2018 May 1.

1 School of Nursing, Duke University, Durham, NC, USA.

The focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reductions. Read More

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July 2018
1 Read

Mortality in Advanced Chronic Obstructive Pulmonary Disease and Heart Failure Following Cardiopulmonary Rehabilitation.

Biol Res Nurs 2018 Jul 29;20(4):429-439. Epub 2018 Apr 29.

2 Health Services Research and Development, VA Puget Sound Health Care System, Seattle, WA, USA.

Cardiopulmonary rehabilitation (CR) improves physical function and quality of life (QoL) in chronic obstructive pulmonary disease (COPD) and heart failure (HF), but it is unknown if CR improves outcomes in very severe disease. This study's purpose was to describe functional capacity (6-min walk distance [6MWD], steps/day), symptoms (dyspnea, depression), QoL (Short-Form Health Survey-Veterans [SF-36 V]) and cardiopulmonary function ( N-terminal pro-brain natriuretic peptide [NT-proBNP], forced expiratory volume in 1 s [FEV]), and derive predictors of mortality among patients with severe COPD and HF who participated in CR.

Methods And Results: In this secondary analysis of a randomized controlled trial comparing two CR methods in severe COPD and HF, 90 (COPD = 63, HF = 27) male veterans, mean age 66 ± 9. Read More

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Mechanisms and Measurement of Changes in Gene Expression.

Biol Res Nurs 2018 Jul 29;20(4):369-382. Epub 2018 Apr 29.

1 Department of Physiological Nursing, School of Nursing, University of California, San Francisco, CA, USA.

Research on gene expression (GE) provides insights into the physiology of a cell or group of cells at a given point in time. Studies of changes in GE can be used to identify patients at higher risk for various medical conditions, a higher symptom burden, and/or the adverse consequences associated with various treatments. The aims of this article are as follows: (1) to describe the different types of RNA transcripts, (2) to describe the processes involved in GE (i. Read More

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Primer in Genetics and Genomics Series: Final Remarks.

Biol Res Nurs 2018 May;20(3):253-254

1 International Society of Nurses in Genetics (ISONG), Pittsburgh, PA, USA.

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May 2018
1 Read

Negative Correlation of Serum Adiponectin Levels With Carotid-Femoral Pulse Wave Velocity in Patients Treated With Hemodialysis.

Biol Res Nurs 2018 Jul 10;20(4):462-468. Epub 2018 Apr 10.

1 Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.

Purpose: The aim of this study was to evaluate the relationship between serum adiponectin levels and carotid-femoral pulse wave velocity (cfPWV) in hemodialysis (HD) patients.

Method: Blood samples were obtained from 120 HD patients. cfPWV was measured with a validated tonometry system (SphygmoCor; AtCor Medical, West Ryde, Australia). Read More

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July 2018
1 Read

Integrative Review of the Relationship Between Sleep Disturbances and Episodic Memory in Older Adults.

Biol Res Nurs 2018 Jul 4;20(4):440-451. Epub 2018 Apr 4.

1 College of Nursing, The University of Nebraska Medical Center, Omaha, NE, USA.

Impaired episodic memory in older adults has been linked to many factors. One of these factors is sleep disturbances, which are reported by more than 50% of older adults. The relationship between episodic memory and sleep disturbances remains unclear, however, because of the multiple types of measures of sleep and episodic memory used in previous studies. Read More

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July 2018
1 Read

Relationships Between Glycemic Control and Cardiovascular Fitness.

Biol Res Nurs 2018 Jul 2;20(4):422-428. Epub 2018 Apr 2.

4 Department of Health Systems Science, College of Nursing, University of Illinois at Chicago, Chicago, IL, USA.

Introduction: Diabetes is a serious health problem affecting approximately 29.1 million individuals in the United States. Another 86 million have prediabetes. Read More

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July 2018
1 Read

A Systematic Review of Biological Mechanisms of Fatigue in Chronic Illness.

Biol Res Nurs 2018 Jul 14;20(4):410-421. Epub 2018 Mar 14.

1 School of Nursing, University of Pennsylvania, Philadelphia, PA, USA.

Fatigue, a commonly reported symptom, is defined as an overwhelming, debilitating, and sustained sense of exhaustion that decreases the ability to function and carry out daily activities. To date, cancer researchers have been in the forefront in investigating the possible biological mechanisms of fatigue, identifying inflammation, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and activation of the autonomic nervous system. The purpose of this systematic review is to describe fatigue and what is known about the biological mechanisms described in cancer in five chronic, noninfectious illnesses: heart failure, multiple sclerosis, chronic kidney disease, rheumatoid arthritis, and chronic obstructive pulmonary disease. Read More

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July 2018
3 Reads

Changes in Oxidant Defense, Apoptosis, and Cognitive Abilities During Treatment for Childhood Leukemia.

Biol Res Nurs 2018 Jul 7;20(4):393-402. Epub 2018 Mar 7.

4 Duke University School of Nursing, Durham, NC, USA.

Aggressive central nervous system (CNS)-directed treatment for acute lymphoblastic leukemia (ALL), the most prevalent cancer among children and adolescents, prevents metastasis of leukemia cells into the brain. Up to 60% of survivors experience cognitive problems, but knowledge about risk factors for and mechanisms of neurologic injury is lacking. Objectives of the present study were to (1) quantify changes in oxidant defense and apoptosis over the course of ALL therapy and (2) elucidate risk factors for long-term cognitive problems. Read More

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July 2018
2 Reads

Altered DNA Methylation Patterns Associated With Clinically Relevant Increases in PTSD Symptoms and PTSD Symptom Profiles in Military Personnel.

Biol Res Nurs 2018 May 7;20(3):352-358. Epub 2018 Mar 7.

1 National Institute of Nursing Research (NINR), National Institutes of Health, Bethesda, MD, USA.

Military personnel experience posttraumatic stress disorder (PTSD), which is associated with differential DNA methylation across the whole genome. However, the relationship between these DNA methylation patterns and clinically relevant increases in PTSD severity is not yet clearly understood. The purpose of this study was to identify differences in DNA methylation associated with PTSD symptoms and investigate DNA methylation changes related to increases in the severity of PTSD in military personnel. Read More

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May 2018
1 Read

Primer in Genetics and Genomics, Article 7-Multifactorial Concepts: Gene-Gene Interactions.

Biol Res Nurs 2018 May 7;20(3):359-364. Epub 2018 Mar 7.

2 Department of Genetics, Genomics, and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

Most common disorders affecting human health are not attributable to simple Mendelian (single-gene) inheritance patterns. Rather, the risk of developing a complex disease is often the result of interactions across genes, whereby one gene modifies the phenotype of another gene. These types of interactions can occur between two or more genes and are referred to as epistasis. Read More

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May 2018
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Comparison of Hair Cortisol Levels and Perceived Stress in Mothers Who Deliver at Preterm and Term.

Biol Res Nurs 2018 May 28;20(3):292-299. Epub 2018 Feb 28.

1 University of South Florida College of Nursing, Tampa, FL, USA.

Objective: To evaluate relationships between hair cortisol levels and perceived stress in mothers who deliver preterm and term. We hypothesized that the rate of change in cortisol levels would be greater in the preterm delivery group.

Methods: This preliminary study compared hair cortisol levels and Perceived Stress Scale (PSS) scores in predominately Caucasian mothers who delivered preterm ( n = 22) and term ( n = 30). Read More

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May 2018
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A Systematic Review of Placental Biomarkers Predicting Small-for-Gestational-Age Neonates.

Biol Res Nurs 2018 May 28;20(3):272-283. Epub 2018 Feb 28.

2 Department of Women, Children & Family Health Science, College of Nursing, University of Illinois at Chicago, Chicago, IL, USA.

Background: Neonates born small for gestational age (SGA) face increased risk of neonatal mortality, childhood developmental problems, and adult disease. The placenta is a key factor in SGA development because of its multiple biological processes that underlie fetal growth. However, valid and reliable placental biomarkers of SGA have not been determined. Read More

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May 2018
1 Read

Different Sickness Responses in Adult and Aged Rats Following Lipopolysaccharide Administration.

Biol Res Nurs 2018 May 25;20(3):335-342. Epub 2018 Feb 25.

3 School of Nursing, Adult Health Nursing, The University of North Carolina at Greensboro, Greensboro, NC, USA.

Objective: Immune challenges result in sickness responses such as decreased activity, fever, and spatial learning deficits. While these responses occur simultaneously, they are not usually evaluated concurrently or for an extended time. The purpose of this study was to examine how an immune challenge affected activity and temperature responses in animals tested concurrently in the Morris water maze (MWM) over 5 days and how aging interacts with such responses. Read More

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May 2018
1 Read

Positive Effects of a Short-Term Intense Elastic Resistance Training Program on Body Composition and Physical Functioning in Overweight Older Women.

Biol Res Nurs 2018 May 11;20(3):321-334. Epub 2018 Feb 11.

2 Research Group in Prevention and Health in Exercise and Sport, University of Valencia, Valencia, Spain.

The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices.

Methods: This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60-85 years, with no medical history of disease that would preclude them from engaging in physical exercise. Read More

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May 2018
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The Effects of Enriched Environmental Intervention on the Parturition Outcome and Filial Health of Pregnant Mice With Chronic Pain.

Biol Res Nurs 2018 May 6;20(3):264-271. Epub 2018 Feb 6.

1 School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Chronic pain (CP) adversely impacts people's health. However, the influence of CP on pregnant women and their fetuses remains unclear. Few reasonable interventions have been offered to these women. Read More

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May 2018
4 Reads

Perceived Stress, Its Physiological Correlates, and Quality of Life in Patients With Irritable Bowel Syndrome.

Biol Res Nurs 2018 May 5;20(3):312-320. Epub 2018 Feb 5.

2 Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.

Irritable bowel syndrome (IBS) is a chronic, common disorder of the gastrointestinal tract associated with high psychological comorbidity and diminished quality of life. Patients with IBS display a heightened sensitivity to stress, although the literature is inconsistent as to whether they have a dysregulated stress response. The purpose of the present investigation, a substudy of a larger research effort, was to examine physiological correlates of perceived stress in patients with IBS (cortisol and adrenocorticotropic hormone) and to explore associations between perceived stress and quality of life. Read More

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May 2018
2 Reads

Epigenetic Modifications Following Noxious Stimuli in Infants.

Biol Res Nurs 2018 Mar 30;20(2):137-144. Epub 2018 Jan 30.

5 University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: To recruit healthy full- and preterm infants into genetic research and determine the effectiveness of a noninvasive DNA sampling technique for comparing epigenetic modifications.

Background: Noxious stimuli during a vulnerable period of infant neuronal plasticity may trigger long-term epigenetic changes affecting neurodevelopment, pain modulation, and reactivity. Recognizing epigenetic pain findings is problematic because parents are reluctant to enroll newborns into genetic research. Read More

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March 2018
1 Read

Genetics and Genomics in Nursing Science.

Biol Res Nurs 2018 Mar 24;20(2):117. Epub 2018 Jan 24.

2 College of Nursing, University of Kentucky, Lexington, KY, USA.

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March 2018
1 Read

The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women.

Biol Res Nurs 2018 Mar 23;20(2):205-217. Epub 2018 Jan 23.

3 Service of Clinical Analysis, University Hospital Dr. Peset-FISABIO, University of Valencia, Valencia, Spain.

This study investigated effects of a 16-week progressive resistance training program (RTP) with elastic bands at two different intensities on systemic redox state, DNA damage, and physical function in healthy older women.

Methods: Participants were randomly assigned to the high-intensity group (HIGH; n = 39), moderate-intensity group (MOD; n = 31), or control group (CG; n = 23). The exercise groups performed an RTP twice a week with three to four sets of 6 (HIGH) or 15 (MOD) repetitions of six overall body exercises at a perceived exertion rate of 8-9 on the OMNI-Resistance Exercise Scale for use with elastic bands. Read More

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March 2018
1 Read

Associating Symptom Phenotype and Genotype in Preeclampsia.

Biol Res Nurs 2018 Mar 22;20(2):126-136. Epub 2018 Jan 22.

4 University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.

Preeclampsia is a complex genetic disorder with an incompletely understood pathogenesis. Its phenotype may be better elucidated by integrating symptoms. This study aimed to identify symptoms by gestational age and associations with novel preeclampsia candidate genes. Read More

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March 2018
1 Read

Delayed Onset of Sleep in Adolescents With PAX6 Haploinsufficiency.

Biol Res Nurs 2018 Mar 17;20(2):237-243. Epub 2018 Jan 17.

1 Unit on Metabolism and Neuroendocrinology, Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Objective: PAX6 haploinsufficiency ( +/-) can occur due to mutations involving only PAX6 in patients with isolated aniridia or as contiguous gene deletions in patients with Wilms tumor, aniridia, genitourinary anomalies, and range of developmental and intellectual disabilities syndrome. Given the role of PAX6 in pineal development and circadian regulation, adolescents with PAX6+/- may experience sleep-wake disturbances. The purpose of this observational study was to explore sleep-related phenotypes in adolescents with PAX6+/-. Read More

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March 2018
2 Reads

Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships.

Biol Res Nurs 2018 Mar 16;20(2):161-167. Epub 2018 Jan 16.

5 Rory Meyers College of Nursing, New York University, New York, NY, USA.

Introduction: Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Read More

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March 2018
3 Reads

Polymorphisms in Estrogen Synthesis Genes and Symptom Clusters During the Menopausal Transition and Early Postmenopause: Observations From the Seattle Midlife Women's Health Study.

Biol Res Nurs 2018 Mar 15;20(2):153-160. Epub 2018 Jan 15.

4 Department of Sociology, University of Washington, Seattle, WA, USA.

During the menopausal transition and early postmenopause, participants in the Seattle Midlife Women's Health Study (SMWHS) experienced one of the three symptom severity clusters identified through latent class analysis: severe hot flashes with moderate sleep, mood, cognitive, and pain symptoms (high-severity hot flash); low-severity hot flashes with moderate levels of all other symptom groups (moderate severity); and low levels of all symptom groups (low severity). In an effort to determine whether gene polymorphisms were associated with these symptom severity classes, we tested associations between gene polymorphisms in the estrogen synthesis pathways (cytochrome P450 19 [CYP 19] and 17 beta hydroxysteroid dehydrogenase [ 17HSDB1]) and the three symptom severity clusters. SMWHS participants ( N = 137) recorded symptoms monthly in diaries and provided buccal smears for genotyping. Read More

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March 2018
1 Read

Inherited Cancer in the Age of Next-Generation Sequencing.

Biol Res Nurs 2018 Mar 11;20(2):192-204. Epub 2018 Jan 11.

1 Counsyl, South San Francisco, CA, USA.

Next-generation sequencing (NGS) technology has led to the ability to test for multiple cancer susceptibility genes simultaneously without significantly increasing cost or turnaround time. With growing usage of multigene testing for inherited cancer, ongoing education for nurses and other health-care providers about hereditary cancer screening is imperative to ensure appropriate testing candidate identification, test selection, and posttest management. The purpose of this review article is to (1) provide an overview of how NGS works to detect germline mutations, (2) summarize the benefits and limitations of multigene panel testing, (3) describe risk categories of cancer susceptibility genes, and (4) highlight the counseling considerations for patients pursuing multigene testing. Read More

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March 2018
1 Read

Expression of Sestrin Genes in Radiotherapy for Prostate Cancer and Its Association With Fatigue: A Proof-of-Concept Study.

Biol Res Nurs 2018 Mar 11;20(2):218-226. Epub 2018 Jan 11.

5 Symptoms Biology Unit, NINR/NIH, Bethesda, MD, USA.

Genetic factors that influence inflammation and energy production/expenditure in cells may affect patient outcomes following treatment with external beam radiation therapy (EBRT). Sestrins, stress-inducible genes with antioxidant properties, have recently been implicated in several behaviors including fatigue. This proof-of-concept study explored whether the sestrin family of genes ( SESN1, SESN2, and SESN3) were differentially expressed from baseline to the midpoint of EBRT in a sample of 26 Puerto Rican men with nonmetastatic prostate cancer. Read More

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March 2018
3 Reads

Symptom Science: Omics Supports Common Biological Underpinnings Across Symptoms.

Biol Res Nurs 2018 Mar 11;20(2):183-191. Epub 2018 Jan 11.

1 University of Pittsburgh School of Nursing, Pittsburgh, PA, USA.

For precision health care to be successful, an in-depth understanding of the biological mechanisms for symptom development and severity is essential. Omics-based research approaches facilitate identification of the biological underpinnings of symptoms. We reviewed literature for omics-based approaches and exemplar symptoms (sleep disruption, cognitive impairment, fatigue, gastrointestinal [GI] distress, and pain) to identify genes associated with the symptom or symptoms across disease processes. Read More

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March 2018
1 Read

Effects of Gender-Specific Differences, Inflammatory Response, and Genetic Variation on the Associations Among Depressive Symptoms and the Risk of Major Adverse Coronary Events in Patients With Acute Coronary Syndrome.

Biol Res Nurs 2018 Mar 3;20(2):168-176. Epub 2018 Jan 3.

1 The University of Texas Health Science Center at Houston, Cizik School of Nursing, Houston, TX, USA.

Depressive symptoms independently contribute to major adverse coronary events (MACEs), with the biological immune response to depression being a likely mediator of this relationship. To determine whether genetic- and/or gender-specific phenotypic differences contribute to associations among depressive symptoms, inflammatory response, and risk of MACE in patients with acute coronary syndrome (ACS), we conducted a prospective study of 1,117 ACS patients to test a gender-specific model in which depressive symptoms (Beck Depression Inventory-II [BDI-II]) are associated with risk of MACE. Cox proportional hazards models were used to model time to incident MACE and determine whether single-nucleotide polymorphisms (SNPs) in specific inflammatory protein-coding genes and depressive symptoms interact to influence levels of inflammatory proteins or risk of MACE. Read More

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March 2018
3 Reads

Evaluation of APOE Genotype and Ability to Perform Activities of Daily Living Following Aneurysmal Subarachnoid Hemorrhage.

Biol Res Nurs 2018 Mar 19;20(2):177-182. Epub 2017 Dec 19.

1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.

Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the central nervous system and to moderate the inflammatory response, making functional variations in this gene likely candidate biomarkers to predict outcomes following aSAH. In the present work, we examined the relationship between APOE genotype and the ability to perform activities of daily living as measured by the Barthel Index (BI) score at 3 months ( n = 298) and 12 months ( n = 288) following aSAH. Read More

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March 2018
6 Reads

Perceived Racial Discrimination and DNA Methylation Among African American Women in the InterGEN Study.

Biol Res Nurs 2018 Mar 19;20(2):145-152. Epub 2017 Dec 19.

1 Yale School of Nursing, Orange, CT, USA.

Introduction: Experiences of racial discrimination have been associated with poor health outcomes. Little is known, however, about how perceived racial discrimination influences DNA methylation (DNAm) among African Americans (AAs). We examined the association of experiences of discrimination with DNAm among AA women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) study. Read More

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March 2018
5 Reads

Pilot Study of Metabolomics and Psychoneurological Symptoms in Women With Early Stage Breast Cancer.

Biol Res Nurs 2018 Mar 19;20(2):227-236. Epub 2017 Dec 19.

7 Virginia Commonwealth University, Richmond, VA, USA.

Many women with breast cancer experience symptoms of pain, fatigue, and depression, collectively known as psychoneurologic (PN) symptoms, during and after chemotherapy treatment. Evidence that inflammatory dysfunction related to cancer and its treatments contributes to the development and persistence of PN symptoms through several interrelated pathways is accumulating. However, a major limiting factor in more precisely identifying the biological mechanisms underlying these symptoms is the lack of biological measures that represent a holistic spectrum of biological responses. Read More

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March 2018
11 Reads

Primer in Genetics and Genomics, Article 6: Basics of Epigenetic Control.

Biol Res Nurs 2018 Jan 23;20(1):103-110. Epub 2017 Nov 23.

2 Rory Meyers College of Nursing, New York, NY, USA.

The epigenome is a collection of chemical compounds that attach to and overlay the DNA sequence to direct gene expression. Epigenetic marks do not alter DNA sequence but instead allow or silence gene activity and the subsequent production of proteins that guide the growth and development of an organism, direct and maintain cell identity, and allow for the production of primordial germ cells (PGCs; ova and spermatozoa). The three main epigenetic marks are (1) histone modification, (2) DNA methylation, and (3) noncoding RNA, and each works in a different way to regulate gene expression. Read More

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January 2018
2 Reads

An Exploration of the Determinants of Gestational Weight Gain in African American Women: Genetic Factors and Energy Expenditure.

Biol Res Nurs 2018 Mar 21;20(2):118-125. Epub 2017 Nov 21.

2 School of Nursing, University of Rochester, Rochester, NY, USA.

Background: Excessive gestational weight gain (GWG) has a long-term impact on women's body weight and contributes to the development of obesity in the mother and her child. Many risk factors for GWG have been identified, but to date, only 6-33.8% of the variance in GWG has been explained. Read More

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March 2018
2 Reads

Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.

Biol Res Nurs 2018 May 15;20(3):284-291. Epub 2017 Nov 15.

4 Mood and Anxiety Program, University of Maryland, Baltimore, MD, USA.

Objective: To evaluate relationships among obesity in pregnancy and plasma levels of tryptophan (TRP) and kynurenine (KYN), inflammatory markers, and depressed mood.

Methods: Pregnant women ( N = 374) were enrolled, and data were collected at a mean gestation of 20 weeks in this cross-sectional study. Plasma was analyzed for TRP, KYN, neopterin, and nitrite levels. Read More

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May 2018
3 Reads

Determining Psychoneuroimmunologic Markers of Yoga as an Intervention for Persons Diagnosed With PTSD: A Systematic Review.

Biol Res Nurs 2018 May 12;20(3):343-351. Epub 2017 Nov 12.

2 Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA, USA.

There is a growing body of research on yoga as a therapeutic intervention for psychological symptoms of post-traumatic stress disorder (PTSD) accompanied by speculations on underlying physiologic mechanisms. The purpose of this systematic review is to identify, qualitatively evaluate, and synthesize studies of yoga as an intervention for PTSD that measured physiologic outcomes in order to gain insights into potential mechanisms. The focus is on studies evaluating yoga as a therapeutic intervention for PTSD rather than for trauma exposure, PTSD prevention, or subclinical PTSD. Read More

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May 2018
2 Reads

The Role of Biomarkers in Research on Caregivers for Cancer Patients: A Scoping Review.

Biol Res Nurs 2018 May 12;20(3):300-311. Epub 2017 Nov 12.

1 National Institutes of Health Clinical Center, Bethesda, MD, USA.

Background: Biomarkers can be used as prognostic, predictive, or monitoring indicators of an associated outcome. The purpose of this review was to provide a comprehensive summary of the research examining the use of biomarkers as surrogate end points for clinical outcomes in family caregivers for cancer patients, identify gaps, and make recommendations for future research.

Methods: A scoping review, a process of mapping the existing literature, was conducted. Read More

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May 2018
2 Reads

Arterial Stiffness Is Associated With QTc Interval Prolongation in Patients With Heart Failure.

Biol Res Nurs 2018 May 26;20(3):255-263. Epub 2017 Oct 26.

4 University of Calgary in Qatar, Qatar.

Background: A prolonged corrected QT (QTc) interval is a known risk factor for adverse cardiac events. Understanding the determinants and physiologic correlates of QTc is necessary for selecting proper strategies to reduce the risk of adverse events in high-risk patients. We sought to evaluate the role of arterial stiffness in heart failure as a determinant of QTc prolongation. Read More

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May 2018
4 Reads

Serum BDNF Is Positively Associated With Negative Symptoms in Older Adults With Schizophrenia.

Biol Res Nurs 2018 Jan 19;20(1):63-69. Epub 2017 Oct 19.

2 Department of Physiological Nursing, University of California, San Francisco, CA, USA.

Objectives: Older adults with chronic schizophrenia are at greater risk for functional disability and poorer health outcomes than those without serious mental illness. These individuals comprise 1-2% of the elderly population in the United States and are projected to number approximately 15 million by 2030. The symptoms of schizophrenia can be disabling for individuals, significantly reducing quality of life. Read More

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January 2018
3 Reads

Increase in Oxytocin From Skin-to-Skin Contact Enhances Development of Parent-Infant Relationship.

Biol Res Nurs 2018 Jan 11;20(1):54-62. Epub 2017 Oct 11.

1 School of Nursing, University of Connecticut, Storrs, CT, USA.

Objective: To examine changes that occur in infant and parent salivary oxytocin (OT) and salivary cortisol (SC) levels during skin-to-skin contact (SSC) and whether SSC alleviates parental stress and anxiety while also supporting mother-father-infant relationships.

Methods: This randomized crossover study was conducted in the neonatal intensive care unit (NICU) with a sample of 28 stable preterm infants and their parents. Saliva samples were collected from infants, mothers, and fathers on Days 1 and 2 (1/parent) for OT and cortisol measurement pre-SSC, during a 60-min SSC session, and a 45-min post-SSC. Read More

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January 2018
6 Reads

Oxytocin Levels in Community-Collected Saliva Samples Transported by Dry Versus Wet Ice.

Biol Res Nurs 2018 Jan 11;20(1):49-53. Epub 2017 Oct 11.

1 Beyster Institute for Nursing Research, Hahn School of Nursing and Health Science, University of San Diego, San Diego, CA, USA.

Oxytocin (OT), a neuropeptide produced primarily in the hypothalamus, is associated with both critical physiological and psychological processes, particularly stress and feelings of affiliation. Increasingly, researchers are seeking ways to reliably incorporate OT as an outcome biomarker in clinical research. Previously, OT levels were measured in plasma or urine. Read More

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January 2018
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Clinical Relevance of Gastrointestinal Microbiota During Pregnancy: A Primer for Nurses.

Biol Res Nurs 2018 Jan 27;20(1):84-102. Epub 2017 Sep 27.

3 School of Nursing, University of Maryland, Baltimore, MD, USA.

Emerging evidence about the human microbiome, a collective term for all the microorganisms living in and on the human body, consistently demonstrates the critical influence it has on host physiology and disease risk. The microbiota in the gastrointestinal (GI) tract has the most significant and far-reaching effect on human physiology. The maternal GI microbiota can decrease the risk of adverse pregnancy outcomes by modulating energy extraction, glucose metabolism, vitamin production, and host immunity essential for optimal maternal and neonatal health. Read More

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January 2018
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Antidepressive Effects of Environmental Enrichment in Chronic Stress-Induced Depression in Rats.

Biol Res Nurs 2018 Jan 21;20(1):40-48. Epub 2017 Sep 21.

5 East-West Nursing Research Institute, College of Nursing Science, Kyung Hee University, Seoul, Republic of Korea.

Depression is caused by a variety of factors, especially stressful life events. Chronic stress-induced depression has detrimental effects on hippocampal integrity. Environmental enrichment (EE) is a beneficial intervention for improving anxiety, fear, and stress. Read More

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January 2018
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Characteristics of Tables for Disseminating Biobehavioral Results.

Biol Res Nurs 2018 Jan 20;20(1):70-76. Epub 2017 Sep 20.

1 School of Nursing, University of Nevada, Las Vegas, NV, USA.

Background: To report the complexity and richness of study variables within biological nursing research, authors often use tables; however, the ease with which consumers understand, synthesize, evaluate, and build upon findings depends partly upon table design.

Objectives: To assess and compare table characteristics within research and review articles published in Biological Research for Nursing and Nursing Research.

Method: A total of 10 elements in tables from 48 biobehavioral or biological research or review articles were analyzed. Read More

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January 2018
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