2,955,373 results match your criteria Biological Research For Nursing [Journal]


Possible involvement of Fas/FasL-dependent apoptotic pathway in α-bisabolol induced cardiotoxicity in zebrafish embryos.

Chemosphere 2018 Dec 8;219:557-566. Epub 2018 Dec 8.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China; Key Laboratory for Drug Screening Technology of Shandong Academy of Sciences, 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China. Electronic address:

α-Bisabolol, an unsaturated monocyclic sesquiterpene alcohol, is a common ingredient in many pharmaceuticals and personal care products (PPCPs). Despite being widely used, little is known about its toxic effects on organisms and aquatic environment. In this study, we investigated the developmental toxicity of α-Bisabolol, especially its effects on the cardiac development using zebrafish embryos as a model. Read More

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December 2018

Checkpoint-modulating immunotherapies in tumor treatment: Targets, drugs, and mechanisms.

Int Immunopharmacol 2018 Dec 12;67:160-175. Epub 2018 Dec 12.

Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Tumor immunotherapy, as a new treatment of cancer, has been developing on the basis of tumor immunology. Tumor immunotherapy stimulates and enhances the function of immune system in human bodies, in order to control and kill tumor cells. It is often used as an adjuvant therapy combined with surgery, chemotherapy, radiotherapy and other conventional methods. Read More

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December 2018

Primary cultured neuronal networks and type 2 diabetes model mouse fatty liver tissues in aqueous liquid observed by atmospheric SEM (ASEM): Staining preferences of metal solutions.

Micron 2018 Nov 23;118:9-21. Epub 2018 Nov 23.

Biomedical Research Institute, National Institute of Industrial Science and Technology (AIST), Higashi 1-1-1, Tsukuba, Ibaraki, 305-8566, Japan. Electronic address:

Neural networking, including axon targeting and synapse formation, is the basis of various brain functions, including memory and learning. Diabetes-mellitus affects peripheral nerves and is known to cause fatty liver disease. Electron microscopy (EM) provides the resolution required to observe changes in fine subcellular structures caused by such physiological and pathological processes, but samples are observed in vacuum. Read More

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November 2018

Detection and quantification of methicillin-resistant Staphylococcus aureus in fresh broiler meat at retail in Germany.

Int J Food Microbiol 2018 Nov 22;292:8-12. Epub 2018 Nov 22.

German Federal Institute for Risk Assessment (BfR), Department Biological Safety, Berlin, Germany. Electronic address:

The aim of this study was to detect, to quantify and to characterize MRSA in broiler meat samples with skin. Furthermore, we compared an isolation method using a second selective enrichment step (method A) with a simpler method omitting this step (method B). For quantification we used a direct plating method on selective agar plates and a "Most probable number" (MPN) technique for estimation of low numbers of MRSA. Read More

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November 2018
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Antibacterial properties of nanofibers containing chrysanthemum essential oil and their application as beef packaging.

Int J Food Microbiol 2018 Dec 8;292:21-30. Epub 2018 Dec 8.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:

This study was aimed to develop novel antibacterial packaging materials in order to reduce the microbial contamination of food surface. Chrysanthemum essential oil (CHEO) was successfully incorporated into chitosan nanofibers (CS/NF) through electrospinning which was demonstrated by SEM and AFM analysis. The antibacterial mechanism of CHEO against Listeria monocytogenes (L. Read More

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December 2018

Molecular alterations in meningiomas: Literature review.

Clin Neurol Neurosurg 2018 Dec 7;176:89-96. Epub 2018 Dec 7.

Departament of Neurology, Laboratory of Molecular and Cellular Biology, LIM15, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil.

Meningiomas, tumors that originate from meningothelial cells, account for approximately 30% of all new diagnoses of central nervous system neoplasms. According to the 2016 WHO classification of central nervous system tumors meningiomas are classified into three grades: I, II, and III. Past studies have shown that the risk of meningiomas recurrence is strongly correlated with the molecular profile of the tumor. Read More

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December 2018

Program implementer perspectives replicating evidence based sexual reproductive health programs.

Eval Program Plann 2018 Dec 6;73:80-87. Epub 2018 Dec 6.

The Johns Hopkins Center for Child & Community Health, Johns Hopkins Bayview Medical Center, 5200 Eastern Avenue, Suite 4200, Mason F. Lord Building, Center Tower, Baltimore, MD 21224, United States.

Purpose: Explore factors affecting implementation of evidence based adolescent sexual/reproductive health programs, from the perspectives of program implementers.

Methods: In-depth interviews were conducted with 18 program implementers delivering six sexual/reproductive health programs in New Jersey. Programs were delivered among 2698 primarily African American and Hispanic adolescents in school and community-based settings. Read More

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December 2018

Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis.

Mult Scler Relat Disord 2018 Nov 30;28:44-49. Epub 2018 Nov 30.

Department of Molecular Cell biology and Immunology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC - location VUmc, Amsterdam, The Netherlands.

Background: Multiple sclerosis (MS) lacks reliable biomarkers that reflect disease activity. Recent evidence suggests that an altered sphingolipid metabolism is associated with MS pathogenesis.

Objective: To explore acid sphingomyelinase (ASM) activity and altered sphingolipid metabolism as potential biomarkers in serum of MS patients, to predict active and progressive disease, and response to disease modifying therapy (DMT). Read More

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November 2018

Influence of the T to S mutation at the STMK motif on antibiotic resistance of penicillin binding protein 1A: A comprehensive computational study.

J Mol Graph Model 2018 Dec 7;87:185-191. Epub 2018 Dec 7.

Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

The emergence of antibiotic resistance has attracted the attention of scientists and scientific circles over the decades. β-Lactam antibiotics resistance is a worldwide therapeutic challenge in bacterial infections, mediated through several mechanisms of which mutations in Penicillin Binding Proteins (PBPs) are an important issue, making critical therapeutic problems in the human population. Accordingly, investigating the dynamic structures of mutant variants could result in a profound understanding of such a specific resistance. Read More

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December 2018

Molecular simulation of the structure of folate and antifolates at physiological conditions.

J Mol Graph Model 2018 Dec 4;87:172-184. Epub 2018 Dec 4.

Laboratory of Quantum and Computational Chemistry, Faculty of Chemistry and Pharmacy, University of Sofia, 1 James Bourchier Blvd, 1164, Sofia, Bulgaria. Electronic address:

The study is focused on description of folate and several antifolates at physiological conditions. Knowledge of the molecular structure and dynamics is important for understanding their biological activity and therapeutic application. They are modelled in saline by atomistic molecular dynamics simulations and characterized in detail. Read More

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December 2018

Excess copper promotes photoinhibition and modulates the expression of antioxidant-related genes in Zostera muelleri.

Aquat Toxicol 2018 Dec 5;207:91-100. Epub 2018 Dec 5.

Climate Change Cluster, University of Technology Sydney, NSW, Australia.

Copper (Cu) is an essential micronutrient for plants and as such is vital to many metabolic processes. Nevertheless, when present at elevated concentrations, Cu can exert toxic effects on plants by disrupting protein functions and promoting oxidative stress. Due to their proximity to the urbanised estuaries, seagrasses are vulnerable to chemical contamination via industrial runoff, waste discharges and leachates. Read More

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December 2018

Near-infrared excited cooperative upconversion in luminescent Ytterbium(ΙΙΙ) bioprobes as light-responsive theranostic agents.

Eur J Med Chem 2018 Dec 5;163:546-559. Epub 2018 Dec 5.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, UP, India. Electronic address:

Near-infrared (NIR) Ytterbium(ΙΙΙ) complexes namely [Yb(dpq)(DMF)Cl] (1), [Yb(dppz)(DMF)Cl] (2), [Yb(dpq)(ttfa)] (3) and [Yb(dppz)(ttfa)] (4) based on photosensitizing antenna: dipyrido-[3,2-d:2',3'-f]-quinoxaline (dpq), dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) and 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (Httfa), were designed as NIR bioimaging agents utilizing cooperative upconversion luminescence (CUCL) of Yb(III). Their structures, detailed photophysical properties, biological interactions, photo-induced DNA cleavage, NIR photocytotoxicity and cellular internalization and bioimaging properties were examined. Discrete mononuclear complexes adopt a seven-coordinated {LnNOCl} mono-capped octahedron (1, 2) and eight-coordinated {LnNO} distorted square antiprism geometry (3, 4) with bidentate N, N-donor dpq, dppz and O,O-donor ttfa ligands. Read More

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December 2018

The therapeutic potential of curcumin: A review of clinical trials.

Eur J Med Chem 2018 Dec 7;163:527-545. Epub 2018 Dec 7.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 11369, Iran; Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB, R3B 2G3, Canada. Electronic address:

Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Read More

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December 2018
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Effects of foliar application of zinc sulfate and zinc nanoparticles in coffee (Coffea arabica L.) plants.

Plant Physiol Biochem 2018 Dec 10;135:160-166. Epub 2018 Dec 10.

Department of Horticultural Sciences and Center for Coffee Research & Education, Texas A&M University, TAMU 2133, College Station, TX, 77843, USA.

A greenhouse study comparing the physiological responses and uptake of coffee (Coffea arabica L.) plants to foliar applications of zinc sulfate (ZnSO) and zinc nano-fertilizer (ZnO NPs) was conducted with the aim to understand their effects on plant physiology. One-year old coffee plants were grown in greenhouse conditions and treated with two foliar applications of 10 mg/L of Zn as either zinc sulfate monohydrate (ZnSO ‧ HO) or zinc oxide nanoparticle (ZnO NPs 20% w/t) and compared to untreated control plants over the course of 45 days. Read More

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December 2018

Cladophora glomerata methanolic extract decreases oxidative stress and improves viability and mitochondrial potential in equine adipose derived mesenchymal stem cells (ASCs).

Biomed Pharmacother 2018 Dec 12;111:6-18. Epub 2018 Dec 12.

Department of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Norwida 27B, 50-375 Wrocław, Poland; Faculty of Veterinary Medicine, Equine Clinic - Equine Surgery, Justus-Liebig-University, 35392 Gießen, Germany. Electronic address:

Reactive oxygen species (ROS) are key mediators of several cellular damage and thus associated with equine diseases such as inflammation and metabolic syndrome. This study aimed to evaluate the protective and antioxidant activities of methanolic extract prepared from Cladophora glomerata (C. glomerata) biomass, on equine adipose derived mesenchymal stem cells (EqASCs), under experimental oxidative stress induced by HO. Read More

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December 2018

Evidence based survey of the distribution volume of ethanol: Comparison of empirically determined values with anthropometric measures.

Forensic Sci Int 2018 Nov 13;294:124-131. Epub 2018 Nov 13.

Principal Forensic Services, Bromley, Kent, UK.

The Widmark equation is commonly used when blood alcohol calculations are required in forensic and legal medicine, such as in road-traffic cases and alcohol-related deaths. An important biological variable in this connection is the volume of distribution (V) of ethanol, which is commonly referred to as the rho-factor. Although a person's V can be determined empirically through controlled drinking experiments, this approach is not very practical in reality. Read More

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November 2018

Delignification overmatches hemicellulose removal for improving hydrolysis of wheat straw using the enzyme cocktail from Aspergillus niger.

Bioresour Technol 2018 Dec 10;274:459-467. Epub 2018 Dec 10.

Department of Biology, Lakehead University, Ontario P7B 5E1, Canada. Electronic address:

Based on a general understanding that hemicellulose removal is more efficient than delignification for biomass deconstruction, an Aspergillus niger strain producing high xylanase activity was screened out from seventeen strains by clear halo experiments. Low-cost enzyme cocktail with high xylanase activity was produced from wheat straw medium fermented by the Gyx086 strain. The enzyme cocktail with high xylanase activity could more effectively hydrolyze wheat straw than other biomasses. Read More

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December 2018

Performance and microbial community of an electric biological integration reactor (EBIR) for treatment of wastewater containing ibuprofen.

Bioresour Technol 2018 Dec 7;274:447-458. Epub 2018 Dec 7.

School of Civil Engineering and Architecture, University of Jinan, Jinan 250022, China; School of Civil Engineering and Architecture, Qilu Institute of Technology, Jinan 250022, China.

Electric biological integration reactor (EBIR) was designed and built for the treatment of wastewater containing ibuprofen. This study evaluates the removal performance of EBIR by comparison with biological aerated filter (BAF), while also discussing the optimal operational parameters of EBIR within the context of the response surface methodology. The results indicate that EBIR exhibits higher average removal rates of ibuprofen, chemical oxygen demand (COD) and NH-N, i. Read More

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December 2018

Enhanced volatile fatty acids production from waste activated sludge anaerobic fermentation by adding tofu residue.

Bioresour Technol 2018 Dec 7;274:430-438. Epub 2018 Dec 7.

College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China.

In this study, an economical and eco-friendly strategy (i.e., adding tofu residue (TR) into waste activated sludge (WAS)) to enhance volatile fatty acid (VFA) production was reported. Read More

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December 2018

Establishing a decision-support system for eco-design of biological wastewater treatment: A case study of bioaugmented constructed wetland.

Bioresour Technol 2018 Dec 7;274:425-429. Epub 2018 Dec 7.

Section of Sanitary Engineering, Department of Water Management, Delft University of Technology, Delft 2628CN, The Netherlands; Veolia Water Technologies Techno Center Netherlands B.V., Tanthofdreef 21, 2623 EW Delft, The Netherlands.

Deep treatment is a common approach to enhance pollutant removal for biological wastewater treatment technologies (BWTTs), and life cycle assessment (LCA) holds substantial advantages to support process optimization. However, there lacks of LCA-based benchmarks that cover human-nature nexuses and stakeholder involvement, which limits the guidance and eco-design of BWTTs. This study proposed a decision-support system (DSS) by linking LCA with Water Quality Model and Conjoint Analysis. Read More

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December 2018
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Meditation, stress processes, and telomere biology.

Curr Opin Psychol 2018 Nov 19;28:92-101. Epub 2018 Nov 19.

University of California, San Francisco, United States. Electronic address:

Both theoretical and empirical work support the notion that meditation training can improve telomere regulation, which may ultimately contribute to healthy aging. Yet, the psychological and biological mechanisms underlying these changes remain underspecified, as do the contexts and boundary conditions in which these changes occur. Here we summarize studies investigating the effects of various meditation-based interventions on telomere biology, making suggestions for future research. Read More

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November 2018

A decade of Nucleic Acid Programmable Protein Arrays (NAPPA) availability: News, actors, progress, prospects and access.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Proteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain; Department of Medicine and General Cytometry Service-Nucleus, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), 37007 Salamanca, Spain. Electronic address:

Understanding the dynamic of the proteome is a critical challenge because it requires high sensitive methodologies in high-throughput formats in order to decipher its modifications and complexity. While molecular biology provides relevant information about cell physiology that may be reflected in post-translational changes, High-Throughput (HT) experimental proteomic techniques are essential to provide valuable functional information of the proteins, peptides and the interconnections between them. Hence, many methodological developments and innovations have been reported during the last decade. Read More

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December 2018

Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 12. Epub 2018 Dec 12.

Department of Biology and Biotechnology "Charles Darwin", La Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.; Pasteur Institute-Cenci Bolognetti Foundation, Viale Regina Elena, 291, 00100 Rome, Italy.. Electronic address:

Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments. With the aim of studying organelle interactions, we discovered that Erg27p resides mainly in Lipid Droplets (LDs) in respiratory competent cells, while in absence of respiration, is found mostly in the ER. Read More

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December 2018

Glucocorticoid receptor (NR3C1) gene polymorphisms are associated with age and blood parameters in Polish Caucasian nonagenarians and centenarians.

Exp Gerontol 2018 Dec 12. Epub 2018 Dec 12.

Mossakowski Medical Research Centre, PAS, Pawinskiego 5, 02-106 Warsaw, Poland; Medical Centre of Postgraduate Education, Marymoncka 99/103, 01-813 Warsaw, Poland. Electronic address:

Introduction: Polymorphism of the glucocorticoid receptor gene (NR3C1) may modify protein abundance or function and therefore disturb human homeostasis.

Methods: Variant frequencies of the three NR3C1 polymorphisms, rs2963154, rs10515522 and rs2918418, selected in silico as associated with longevity, was analyzed in 552 DNA samples from 95 to 106-year-old individuals and in 284 samples of cord blood DNA from newborns.

Results: Frequencies of the TT genotypes of rs2963154 and rs10515522, and of the rs291841 CC genotype, were higher in the long-lived study subjects (p = 0. Read More

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December 2018

Alpha-synuclein is highly prone to distribution in the hippocampus and midbrain in tree shrews, and its fibrils seed Lewy body-like pathology in primary neurons.

Exp Gerontol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China; Medical Primate Research Center & Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100005, China; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Diseases, Kunming 650118, China. Electronic address:

The Chinese tree shrew (TS) has many unique advantages that make it suitable for use as an experimental animal model for human disease including moderate body size, low cost of feeding, short reproductive cycle and lifespan, and close phylogenetic relationship to primates. Our previous studies have shown that TS treated with the mitochondrial inhibitor MPTP displayed classic Parkinsonian symptoms. Additionally, the structure of TS alpha-synuclein (α-syn) is highly homologous to that found in humans. Read More

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December 2018

Biology of preeclampsia: Combined actions of angiogenic factors, their receptors and placental proteins.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 12. Epub 2018 Dec 12.

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria. Electronic address:

Although massive efforts have been undertaken to elucidate the etiology of the pregnancy syndrome preeclampsia, its developmental origin remains a mystery. Most efforts of the last decade have focused on biomarkers to predict and/or diagnose preeclampsia, including the anti-angiogenic factor sFlt-1 (soluble fms-like tyrosin kinase-1), the angiogenic factor PGF (placental growth factor) and PP13 (placental protein 13). The origins of these marker proteins are still under debate, and so far their actions have only been describe separate from each other. Read More

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December 2018

Clinical signs of meibomian gland dysfunction (MGD) are associated with changes in meibum sphingolipid composition.

Ocul Surf 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Anatomy and Neurobiology, University of Tennessee Health Sciences Center, Hamilton Eye Institute, 930 Madison Avenue, Memphis, TN, 38163, USA. Electronic address:

Purpose: Sphingolipids (SPL) play roles in cell signaling, inflammation, and apoptosis. Changes in SPL composition have been reported in individuals with MGD, but associations between clinical signs of MGD and compositional changes in meibum SPLs have not been examined.

Methods: Forty-three individuals underwent a tear film assessment. Read More

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December 2018
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Immuno-Spin Trapping of Macromolecules Free Radicals In Vitro and In Vivo - One Stop Shopping for Free Radical Detection.

Free Radic Biol Med 2018 Dec 12. Epub 2018 Dec 12.

Inflammation, Immunity and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Electronic address:

The only general technique that allows the unambiguous detection of free radicals is electron spin resonance (ESR). However, ESR spin trapping has severe limitations especially in biological systems. The greatest limitation of ESR is poor sensitivity relative to the low steady-state concentration of free radical adducts, which in cells and in vivo is much lower than the best sensitivity of ESR. Read More

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December 2018

The RNA helicase DHX33 is required for cancer cell proliferation in human glioblastoma and confers resistance to PI3K/mTOR inhibition.

Cell Signal 2018 Dec 12. Epub 2018 Dec 12.

Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China. Electronic address:

Human Glioblastoma is one deadly disease; the median survival time is reported to be 13.9 months after treatment. In the present study, we discovered that DHX33 is highly expressed in 84% of all Glioblastoma multiforme (GBM). Read More

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December 2018

Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Given the multifactorial state of autoimmune complex diseases such as multiple sclerosis (MS), it is not clear if different risk factors act jointly or independently. Despite intensive studies investigating multi aspects of MS risk factors, findings with regards to potential biomarkers that may link these risk factors remained largely inconclusive. System biology or data integration utilizes different validated datasets to extract meaningful information and map the plausible biological pathways and networks. Read More

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December 2018

Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance.

Prog Retin Eye Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

In the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing smooth muscle, blood vessels and peripheral nerves to the innermost and highly protected neural retina. The extravascular environment of the neural retina, like the brain parenchyma, is stringently controlled to maintain conditions required for neural transmission. The unique physiological nature of the neural retina can be attributed to the blood retinal barriers (BRB) of the retinal vasculature and the retinal pigment epithelium, which both tightly regulate the transport of small molecules and restrict passage of cells and macromolecules from the circulation into the retina in a similar fashion to the blood brain barrier (BBB). Read More

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December 2018

Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease.

Pharmacol Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Section of Pharmacology, University of Perugia, Italy.

Cannabinoids are known to possess anti-inflammatory and immunomodulatory properties, but the mechanisms involved are not fully understood. CB2 is the cannabinoid receptor that is expressed primarily on hematopoietic cells and mediates the immunoregulatory functions of cannabinoids. In order to study the effect of JTE907, a selective/inverse agonist of CB2 with anti-inflammatory properties, on the differentiation of T cell subtypes, we used an in vitro system of Th lineage-specific differentiation of naïve CD4 T lymphocytes isolated from the mouse spleen. Read More

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December 2018
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Sustained release of recombinant thrombomodulin from cross-linked gelatin/hyaluronic acid hydrogels potentiate wound healing in diabetic mice.

Eur J Pharm Biopharm 2018 Dec 12. Epub 2018 Dec 12.

nstitute of Clinical Pharmacy and Pharmaceutical Sciences, Southern Taiwan University of Science and Technology, Tainan, Taiwan. Electronic address:

Thrombomodulin (TM) is a type-I transmembrane glycoprotein expressed on the surfaces of endothelial cells and epidermal keratinocytes. It is known to regulate blood coagulation, inflammation, and cell-cell adhesion. A recombinant TM, which contains an epidermal growth factor - like domain and serine/threonine-riches domain, has been demonstrated to stimulate cell proliferation and migration of keratinocytes and wound healing. Read More

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December 2018

Biogenic nanomaterials: Synthesis, characterization, growth mechanism, and biomedical applications.

J Microbiol Methods 2018 Dec 12. Epub 2018 Dec 12.

School of Pharmacy, Sungkyunkwan University, 2066 Seoburo, Jangan-gu, Suwon, Gyeonggido 16419, Republic of Korea. Electronic address:

The biosynthesis of nanomaterials is a huge and intensifying field of research due to their application in various areas, in particular the biomedical and pharmaceutical fields. In this review, we focused on the biosynthesis of both metallic and semiconductor nanomaterials and their application in biomedicine and pharmaceutics. In order to meet an exponentially increasing need for nanostructured materials, the biological route for the synthesis of nanomaterials will have to be explored, offering advantages over chemical and physical methods as a simpler, more cost effective, and environmentally friendly method, and for which there is no need to use high pressure and temperatures or toxic chemicals. Read More

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December 2018

Ultra-high field magnetic resonance imaging parameter mapping in the posterior horn of ex vivo human menisci.

Osteoarthritis Cartilage 2018 Dec 12. Epub 2018 Dec 12.

Medical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden; Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden. Electronic address:

Objective: To investigate the relationship between meniscus magnetic resonance (MR) relaxation parameters and meniscus degradation through quantitative imaging of ex vivo posterior horns of menisci from subjects with and without knee osteoarthritis (OA).

Design: We sampled medial and lateral menisci from ten medial compartment knee OA patients (mean age 63 years) undergoing total knee replacement and from ten deceased donors (references, mean age 51 years). MR relaxation parameters T2*, T2 and T1 of the posterior horn were measured at a 9. Read More

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December 2018

Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring in- and out-of-field.

Int J Radiat Oncol Biol Phys 2018 Dec 12. Epub 2018 Dec 12.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland, UK.

Purpose: The aim of this study was to define the dose and dose-volume relationship of radiation induced pulmonary toxicities occurring in and out-of-field in mouse models of early inflammatory and late fibrotic response.

Materials And Methods: Early radiation induced inflammation and fibrosis were investigated in C3H/NeJ and C57BL/6J mice respectively. Animals were irradiated with 20 Gy delivered to the upper region of the right lung as a single fraction or as three consecutive fractions using the Small Animal Radiation Research Platform (SARRP, Xstrahl Inc. Read More

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December 2018

Altered α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function and expression in hippocampus in a rat model of attention-deficit/hyperactivity disorder (ADHD).

Behav Brain Res 2018 Dec 12. Epub 2018 Dec 12.

The Brain and Muscle Energy Group, Electron Microscopy Laboratory, Department of Oral Biology, University of Oslo, NO-0316, Oslo, Norway; Synaptic Neurochemistry and Amino Acid Transporters Labs, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences (IMB) and Healthy Brain Ageing Centre (SERTA), University of Oslo, NO-0317, Oslo, Norway; Center for Healthy Aging, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

Glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) carry the bulk of excitatory synaptic transmission. Their modulation plays key roles in synaptic plasticity, which underlies hippocampal learning and memory. A dysfunctional glutamatergic system may negatively affect learning abilities and underlie symptoms of attention-deficit/hyperactivity disorder (ADHD). Read More

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December 2018

Novel multifunctional nanocomposite for root caries restorations to inhibit periodontitis-related pathogens.

J Dent 2018 Dec 12. Epub 2018 Dec 12.

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

Objectives: The objectives of this study were to: (1) develop a novel multifunctional composite with nanoparticles of silver (NAg), 2-methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP); and (2) investigate biofilm-inhibition via the multifunctional nanocomposite against three species of periodontal pathogens for the first time.

Methods: The multifunctional nanocomposite was fabricated by incorporating NAg, MPC, DMAHDM and NACP into the resin consisting of pyromellitic glycerol dimethacrylate (PMDGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). Three species (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum) were tested for metabolic activity (MTT), live/dead staining, polysaccharide production and colony-forming units (CFU) of biofilms grown on resins. Read More

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December 2018

Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice.

Mol Cell Endocrinol 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

The role of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in browning and thermogenesis has not been fully elucidated. Thus, we meant to evaluate the effect of EPA and DHA, administered alone or combined, with the activation of browning markers in subcutaneous white adipose tissue (sWAT), and thermogenic markers in brown adipose tissue (BAT). C57BL/6 adult male mice received a control diet or a high-fructose diet (HFru) for eight weeks, but after the first three weeks, HFru was divided into new groups: HFru, HFru + EPA, HFru + DHA, and HFru-EPA + DHA. Read More

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December 2018

Superparamagnetic Iron Oxides as MPI Tracers: A Primer and Review of early applications.

Authors:
J W M Bulte

Adv Drug Deliv Rev 2018 Dec 12. Epub 2018 Dec 12.

Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Department of Chemical & Biomolecular Engineering, Department of Biomedical Engineering, and Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

Magnetic particle imaging (MPI) has recently emerged as a non-invasive, whole body imaging technique that detects superparamagnetic iron oxide (SPIO) nanoparticles similar as those used in magnetic resonance imaging (MRI). Based on tracer "hot spot" detection instead of providing contrast on MRI scans, MPI has already proven to be truly quantitative. Without the presence of endogenous background signal, MPI can also be used in certain tissues where the endogenous MRI signal is too low to provide contrast. Read More

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December 2018

Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond.

Adv Drug Deliv Rev 2018 Dec 12. Epub 2018 Dec 12.

MedImmune, Gaithersburg, MD 20878, United States. Electronic address:

CD40 is a TNF receptor superfamily member expressed on both immune and non-immune cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies. Non-hematopoietic cells expressing CD40 can also engage CD40L and trigger a pro-inflammatory response. Read More

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December 2018

Epinecidin-1: A marine fish antimicrobial peptide with therapeutic potential against Trichomonas vaginalis infection in mice.

Peptides 2018 Dec 12. Epub 2018 Dec 12.

Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan. Electronic address:

Trichomoniasis is caused by infection with the protozoan parasite Trichomonas vaginalis, and prolonged persistence may lead to serious ill effects in patients. Thus, the development of new therapeutic strategies to combat drug-resistant T. vaginalis would be clinically beneficial. Read More

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December 2018

A two-player iterated survival game.

Theor Popul Biol 2018 Dec 12. Epub 2018 Dec 12.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA; Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA; Department of Mathematics, Harvard University, Cambridge, MA 02138, USA.

We describe an iterated game between two players, in which the payoff is to survive a number of steps. Expected payoffs are probabilities of survival. A key feature of the game is that individuals have to survive on their own if their partner dies. Read More

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December 2018

The influence of the OPRM1 (A118G) polymorphism on behavioral and neural correlates of aggression in healthy males.

Neuropharmacology 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen University, 52074, Aachen, Germany; JARA Institute Brain Structure Function Relationship Institute for Neuroscience and Medicine (INM 10), Forschungszentrum Jülich, 52425 Jülich, Germany.

Current models of aggression suggest that in addition to personality traits and environmental factors, biological vulnerability associated with genetics substantially impacts aggressive behavior. In a functional imaging study, we investigated the influence of the single nucleotide polymorphism of the mu 1 subtype opioid receptor gene (OPRM1), implicated in sociability, on correlates of trait and state aggression to delineate the function of these influences in aggression. A key aim was further to differentiate different aspects of aggressive reactions - namely, the reaction to provocation and the decision to punish an opponent. Read More

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December 2018

Stimulation of TRPM3 channels increases the transcriptional activation potential of Elk-1 involving cytosolic Ca, extracellular signal-regulated protein kinase, and calcineurin.

Eur J Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Biochemistry and Molecular Biology Saarland University Medical Faculty D-66421 Homburg, Germany. Electronic address:

Stimulation of transient receptor potential M3 (TRPM3) channels with the steroid pregnenolone sulfate increases the transcriptional activation potential of Elk-1, a transcription factor that regulates serum response element-mediated transcription. Here, we show that an influx of Ca ions into the cells is essential for the activation of Elk-1 following stimulation of TRPM3. Using genetically encoded Ca buffers, we show that a rise in cytoplasmic Ca is required for the upregulation of the transcriptional activation potential of Elk-1, while buffering of Ca in the nucleus had no inhibitory effect on the transcriptional activity of Elk-1. Read More

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December 2018
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LeishInDB: a web-accessible resource for small molecule inhibitors against Leishmania sp.

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Department of Molecular Biology/Bioinformatics Centre, Rajendra Memorial Research Institute of Medical Science, Indian Council for Medical Research, Agamkuan, Patna, Bihar 800007. India.

Despite the availability of drugs to treat Leishmaniasis, various other factors including drug resistance and adverse side effects encourage the researchers to search for new strategies and alternatives for treating Leishmaniasis. Repurposing and devising combination therapy with the existing small molecules would serve as an alternative strategy to address the issue, especially the drug resistance. Hence, here we report LeishInDB, a web-accessible resource of small molecule inhibitors having a varying degree of activity towards Leishmania sp. Read More

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December 2018

Darpp-32 and t-Darpp protein products of PPP1R1B: old dogs with new tricks.

Biochem Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry and Biochemistry, California State University, Los Angeles, CA, USA. Electronic address:

The PPP1R1B gene is located on chromosome 17q12 (39,626,208-39,636,626[GRCh38/hg38]), which codes for multiple transcripts and two experimentally-documented proteins Darpp-32 and t-Darpp. Darpp-32 (Dopamine and cAMP Regulated Phosphoprotein), discovered in the early 1980s, is a protein whose phosphorylation is upregulated in response to cAMP in dopamine-responsive tissues in the brain. It's phosphorylation profile modulates its ability to bind and inhibit Protein Phosphatase 1 activity, which, in turn, controls the activity of hundreds of phosphorylated proteins. Read More

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December 2018
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Phage-based assay for rapid detection of bacterial pathogens in blood by Raman spectroscopy.

J Immunol Methods 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy. Electronic address:

Sepsis is a systemic inflammatory response ensuing from presence and persistence of microorganisms in the bloodstream. The possibility to identify them at low concentrations may improve the problem of human health and therapeutic outcomes. So, sensitive and rapid diagnostic systems are essential to evaluate bacterial infections during the time, also reducing the cost. Read More

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December 2018
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FGFR1 regulates trophectoderm development and facilitates blastocyst implantation.

Dev Biol 2018 Dec 12. Epub 2018 Dec 12.

Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029. Electronic address:

FGF signaling plays important roles in many aspects of mammalian development. Fgfr1 and Fgfr1Fgfr2 mouse embryos on a 129S4 co-isogenic background fail to survive past the peri-implantation stage, whereas Fgfr2 embryos die at midgestation and show defects in limb and placental development. To investigate the basis for the Fgfr1 and Fgfr1Fgfr2 peri-implantation lethality, we examined the role of FGFR1 and FGFR2 in trophectoderm (TE) development. Read More

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December 2018

Role of host genetics and heat tolerant algal symbionts in sustaining populations of the endangered coral Orbicella faveolata in the Florida Keys with ocean warming.

Glob Chang Biol 2018 Dec 15. Epub 2018 Dec 15.

Atlantic Oceanographic and Meteorological Laboratories (AOML), NOAA, 4301 Rickenbacker Cswy, Miami, FL, 33149 USA.

Identifying which factors lead to coral bleaching resistance is a priority given the global decline of coral reefs with ocean warming. During the second year of back-to-back bleaching events in the Florida Keys in 2014 and 2015, we characterized key environmental and biological factors associated with bleaching resilience in the threatened reef-building coral Orbicella faveolata. Ten reefs (five inshore, five offshore, 179 corals total) were sampled during bleaching (September 2015) and recovery (May 2016). Read More

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December 2018
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