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    760 results match your criteria Biological Research For Nursing [Journal]

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    Primer in Genetics and Genomics, Article 6: Basics of Epigenetic Control.
    Biol Res Nurs 2017 Jan 1:1099800417742967. Epub 2017 Jan 1.
    2 Rory Meyers College of Nursing, New York, NY, USA.
    The epigenome is a collection of chemical compounds that attach to and overlay the DNA sequence to direct gene expression. Epigenetic marks do not alter DNA sequence but instead allow or silence gene activity and the subsequent production of proteins that guide the growth and development of an organism, direct and maintain cell identity, and allow for the production of primordial germ cells (PGCs; ova and spermatozoa). The three main epigenetic marks are (1) histone modification, (2) DNA methylation, and (3) noncoding RNA, and each works in a different way to regulate gene expression. Read More

    An Exploration of the Determinants of Gestational Weight Gain in African American Women: Genetic Factors and Energy Expenditure.
    Biol Res Nurs 2017 Jan 1:1099800417743326. Epub 2017 Jan 1.
    2 School of Nursing, University of Rochester, Rochester, NY, USA.
    Background: Excessive gestational weight gain (GWG) has a long-term impact on women's body weight and contributes to the development of obesity in the mother and her child. Many risk factors for GWG have been identified, but to date, only 6-33.8% of the variance in GWG has been explained. Read More

    Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
    Biol Res Nurs 2017 Jan 1:1099800417738363. Epub 2017 Jan 1.
    4 Mood and Anxiety Program, University of Maryland, Baltimore, MD, USA.
    Objective: To evaluate relationships among obesity in pregnancy and plasma levels of tryptophan (TRP) and kynurenine (KYN), inflammatory markers, and depressed mood.

    Methods: Pregnant women ( N = 374) were enrolled, and data were collected at a mean gestation of 20 weeks in this cross-sectional study. Plasma was analyzed for TRP, KYN, neopterin, and nitrite levels. Read More

    Determining Psychoneuroimmunologic Markers of Yoga as an Intervention for Persons Diagnosed With PTSD: A Systematic Review.
    Biol Res Nurs 2017 Jan 1:1099800417739152. Epub 2017 Jan 1.
    2 Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA, USA.
    There is a growing body of research on yoga as a therapeutic intervention for psychological symptoms of post-traumatic stress disorder (PTSD) accompanied by speculations on underlying physiologic mechanisms. The purpose of this systematic review is to identify, qualitatively evaluate, and synthesize studies of yoga as an intervention for PTSD that measured physiologic outcomes in order to gain insights into potential mechanisms. The focus is on studies evaluating yoga as a therapeutic intervention for PTSD rather than for trauma exposure, PTSD prevention, or subclinical PTSD. Read More

    The Role of Biomarkers in Research on Caregivers for Cancer Patients: A Scoping Review.
    Biol Res Nurs 2017 Jan 1:1099800417740970. Epub 2017 Jan 1.
    1 National Institutes of Health Clinical Center, Bethesda, MD, USA.
    Background: Biomarkers can be used as prognostic, predictive, or monitoring indicators of an associated outcome. The purpose of this review was to provide a comprehensive summary of the research examining the use of biomarkers as surrogate end points for clinical outcomes in family caregivers for cancer patients, identify gaps, and make recommendations for future research.

    Methods: A scoping review, a process of mapping the existing literature, was conducted. Read More

    Arterial Stiffness Is Associated With QTc Interval Prolongation in Patients With Heart Failure.
    Biol Res Nurs 2017 Jan 1:1099800417737835. Epub 2017 Jan 1.
    4 University of Calgary in Qatar, Qatar.
    Background: A prolonged corrected QT (QTc) interval is a known risk factor for adverse cardiac events. Understanding the determinants and physiologic correlates of QTc is necessary for selecting proper strategies to reduce the risk of adverse events in high-risk patients. We sought to evaluate the role of arterial stiffness in heart failure as a determinant of QTc prolongation. Read More

    Serum BDNF Is Positively Associated With Negative Symptoms in Older Adults With Schizophrenia.
    Biol Res Nurs 2017 Jan 1:1099800417735634. Epub 2017 Jan 1.
    2 Department of Physiological Nursing, University of California, San Francisco, CA, USA.
    Objectives: Older adults with chronic schizophrenia are at greater risk for functional disability and poorer health outcomes than those without serious mental illness. These individuals comprise 1-2% of the elderly population in the United States and are projected to number approximately 15 million by 2030. The symptoms of schizophrenia can be disabling for individuals, significantly reducing quality of life. Read More

    Increase in Oxytocin From Skin-to-Skin Contact Enhances Development of Parent-Infant Relationship.
    Biol Res Nurs 2017 Jan 1:1099800417735633. Epub 2017 Jan 1.
    1 School of Nursing, University of Connecticut, Storrs, CT, USA.
    Objective: To examine changes that occur in infant and parent salivary oxytocin (OT) and salivary cortisol (SC) levels during skin-to-skin contact (SSC) and whether SSC alleviates parental stress and anxiety while also supporting mother-father-infant relationships.

    Methods: This randomized crossover study was conducted in the neonatal intensive care unit (NICU) with a sample of 28 stable preterm infants and their parents. Saliva samples were collected from infants, mothers, and fathers on Days 1 and 2 (1/parent) for OT and cortisol measurement pre-SSC, during a 60-min SSC session, and a 45-min post-SSC. Read More

    Oxytocin Levels in Community-Collected Saliva Samples Transported by Dry Versus Wet Ice.
    Biol Res Nurs 2017 Jan 1:1099800417735632. Epub 2017 Jan 1.
    1 Beyster Institute for Nursing Research, Hahn School of Nursing and Health Science, University of San Diego, San Diego, CA, USA.
    Oxytocin (OT), a neuropeptide produced primarily in the hypothalamus, is associated with both critical physiological and psychological processes, particularly stress and feelings of affiliation. Increasingly, researchers are seeking ways to reliably incorporate OT as an outcome biomarker in clinical research. Previously, OT levels were measured in plasma or urine. Read More

    Clinical Relevance of Gastrointestinal Microbiota During Pregnancy: A Primer for Nurses.
    Biol Res Nurs 2017 Jan 1:1099800417732412. Epub 2017 Jan 1.
    3 School of Nursing, University of Maryland, Baltimore, MD, USA.
    Emerging evidence about the human microbiome, a collective term for all the microorganisms living in and on the human body, consistently demonstrates the critical influence it has on host physiology and disease risk. The microbiota in the gastrointestinal (GI) tract has the most significant and far-reaching effect on human physiology. The maternal GI microbiota can decrease the risk of adverse pregnancy outcomes by modulating energy extraction, glucose metabolism, vitamin production, and host immunity essential for optimal maternal and neonatal health. Read More

    Antidepressive Effects of Environmental Enrichment in Chronic Stress-Induced Depression in Rats.
    Biol Res Nurs 2017 Jan 1:1099800417730400. Epub 2017 Jan 1.
    5 East-West Nursing Research Institute, College of Nursing Science, Kyung Hee University, Seoul, Republic of Korea.
    Depression is caused by a variety of factors, especially stressful life events. Chronic stress-induced depression has detrimental effects on hippocampal integrity. Environmental enrichment (EE) is a beneficial intervention for improving anxiety, fear, and stress. Read More

    Characteristics of Tables for Disseminating Biobehavioral Results.
    Biol Res Nurs 2017 Jan 1:1099800417724901. Epub 2017 Jan 1.
    1 School of Nursing, University of Nevada, Las Vegas, NV, USA.
    Background: To report the complexity and richness of study variables within biological nursing research, authors often use tables; however, the ease with which consumers understand, synthesize, evaluate, and build upon findings depends partly upon table design.

    Objectives: To assess and compare table characteristics within research and review articles published in Biological Research for Nursing and Nursing Research.

    Method: A total of 10 elements in tables from 48 biobehavioral or biological research or review articles were analyzed. Read More

    Primer in Genetics and Genomics, Article 5-Further Defining the Concepts of Genotype and Phenotype and Exploring Genotype-Phenotype Associations.
    Biol Res Nurs 2017 Oct;19(5):576-585
    2 Scientific Project Leader, Flatiron Health, New York, NY, USA.
    As nurses begin to incorporate genetic and genomic sciences into clinical practice, education, and research, it is essential that they have a working knowledge of the terms foundational to the science. The first article in this primer series provided brief definitions of the basic terms (e.g. Read More

    Spatial Learning Responses to Lipopolysaccharide in Adult and Aged Rats.
    Biol Res Nurs 2017 Jan 1:1099800417726875. Epub 2017 Jan 1.
    2 School of Nursing, University of Michigan, Ann Arbor, MI, USA.
    Sickness behaviors, adaptive responses to infections, include lethargy, depression, reduced eating and grooming, and concentration problems resulting from interactions between the immune and neuroendocrine systems. Detecting these responses is especially critical in the elderly, as the infections that cause them can lead to cognitive impairment. While deficits in spatial learning, a hippocampal-dependent form of learning, are part of the sickness response, directional heading errors (DHEs; an indicator of spatial-learning deficits) and their time trajectories need further examination. Read More

    Differences Between Sleep Logs and Actigraphy Combined With Electroencephalography in Adults With Sleep Disturbances.
    Biol Res Nurs 2017 Jan 1:1099800417725599. Epub 2017 Jan 1.
    4 Department of Nursing, Tzu Chi University, Hualien, Taiwan.
    Background: Actigraphy plus single-channel electroencephalography (EEG) has a high agreement with polysomnography and is considered a simple method for monitoring sleep at home. No studies, however, have evaluated its agreement with sleep logs.

    Purpose: A sleep log was compared to a single-channel EEG in adults with sleep disturbances. Read More

    Factors That Influence Blood Pressure in 3- to 5-Year-Old Children: A Pilot Study.
    Biol Res Nurs 2017 Jan 1:1099800417726598. Epub 2017 Jan 1.
    1 School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
    While incident elevations in blood pressure (BP) are apparent in preschool years, factors influencing BP in this population have received little attention. The purposes of this pilot study were to determine the feasibility of collecting data from preschoolers and their mothers and to determine effect sizes of relationships between BP and sex, race, birth status, body mass index (BMI), waist circumference (WC), geographic location, serum C-reactive protein (CRP), and salivary cortisol (morning, afternoon). A hypothesis-generating correlational design was used; 56 children, aged 3-5 years, were enrolled from six rural and urban Head Start programs in a southeastern state. Read More

    Searching for Evidence of an Anti-Inflammatory Diet in Children: A Systematic Review of Randomized Controlled Trials for Pediatric Obesity Interventions With a Focus on Leptin, Ghrelin, and Adiponectin.
    Biol Res Nurs 2017 Oct 26;19(5):511-530. Epub 2017 Jul 26.
    1 School of Nursing, The University of Texas at Austin, Austin, TX, USA.
    Problem: To address the complex phenomenon of pediatric obesity, one must understand the physiological mechanisms regulating energy intake and inflammation. The peptide hormones leptin, ghrelin, and adiponectin are involved in both, but their functions are dysregulated in obesity. The purpose of this systematic review is (1) to characterize studies of nutrition interventions for weight management in children who measure these peptides as outcomes, (2) to assess risk of bias in the studies, and (3) to determine the relationships between these peptides and body mass index (BMI). Read More

    Long-Term Effects of Prematurity, Cumulative Medical Risk, and Proximal and Distal Social Forces on Individual Differences in Diurnal Cortisol at Young Adulthood.
    Biol Res Nurs 2017 Jan 1:1099800417718955. Epub 2017 Jan 1.
    3 Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, USA.
    This study examined the effects of prematurity, cumulative medical risk, and proximal and distal social forces on individual differences in the activity of the hypothalamic-pituitary-adrenal (HPA) axis in young adulthood. A prospective sample of 149 infants born healthy preterm (PT; n = 22), sick PT ( n = 93, medical illness, neurological illness, small for gestational age), and full term ( n = 34) was recruited from a Level III neonatal intensive care unit in southern New England between 1985 and 1989 and followed to age 23 years. Cumulative medical risk was indexed across seven assessment waves (spanning 17 years) using medical and neurological health status at birth, toddlerhood (ages 18 and 30 months), childhood (ages 4 and 8 years), and adolescence (ages 12 and 17 years). Read More

    Quantitative Sensory Testing and Current Perception Threshold Testing in Patients With Chronic Pain Following Lower Extremity Fracture.
    Biol Res Nurs 2017 Jan 1:1099800417720725. Epub 2017 Jan 1.
    3 School of Nursing, University of Maryland, Baltimore, MD, USA.
    Background: Chronic pain is a significant problem for patients with lower extremity injuries. While pain hypersensitivity has been identified in many chronic pain conditions, it is not known whether patients with chronic pain following lower extremity fracture report pain hypersensitivity in the injured leg.

    Purpose: To quantify and compare peripheral somatosensory function and sensory nerve activation thresholds in persons with chronic pain following lower extremity fractures with a cohort of persons with no history of lower extremity fractures. Read More

    From Donor to Recipient: Considerations for Blood Transfusion Outcomes Research.
    Biol Res Nurs 2017 Oct 17;19(5):491-498. Epub 2017 Jul 17.
    1 School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
    Donated blood can be broken down into blood components for use in patient care. This article focuses primarily on packed red blood cells (PRBCs), as they experience breakdown during storage that may adversely impact patient outcomes. Patients require PRBC transfusions for a number of clinical reasons. Read More

    Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization.
    Biol Res Nurs 2017 Oct 12;19(5):549-558. Epub 2017 Jul 12.
    2 The Ohio State University College of Nursing, Columbus, OH, USA.
    Extremely premature infants are at great risk for poor neurodevelopmental outcomes, in part because neurologic structures designed to mature in the womb must now do so in the extrauterine environment. Reliable biomarkers of neurodevelopment are especially critical in this population, as behavioral measures can be unreliable due to immaturity of the premature infant nervous system. Oxytocin (OT) has the potential to be a marker of neurobiological processes that offer infant neuroprotection. Read More

    Genetic Basis of Positive and Negative Symptom Domains in Schizophrenia.
    Biol Res Nurs 2017 Oct 10;19(5):559-575. Epub 2017 Jul 10.
    2 Duke Center for Applied Genomics and Precision Medicine, Duke University School of Nursing, Durham, NC, USA.
    Schizophrenia is a highly heritable disorder, the genetic etiology of which has been well established. Yet despite significant advances in genetics research, the pathophysiological mechanisms of this disorder largely remain unknown. This gap has been attributed to the complexity of the polygenic disorder, which has a heterogeneous clinical profile. Read More

    The Relation Between Physical Activity and Cognitive Change in Older Latinos.
    Biol Res Nurs 2017 Oct 29;19(5):538-548. Epub 2017 Jun 29.
    2 Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
    Cognitive impairment in older Latinos is of concern due to the rapid growth of this population and their increased risk for dementia due to chronic disease. Evidence, primarily from studies of non-Latino Whites, suggests that physical activity (PA) may reduce cognitive decline. Few longitudinal studies have included older Latinos, objective measures of PA, or neurocognitive tests that assess domains of cognition. Read More

    Measuring Light at Night and Melatonin Levels in Shift Workers: A Review of the Literature.
    Biol Res Nurs 2017 Jul;19(4):365-374
    1 Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, USA.
    Shift work, especially that involving rotating and night shifts, is associated with an increased risk of diseases, including cancer. Attempts to explain the association between shift work and cancer in particular have focused on the processes of melatonin production and suppression. One hypothesis postulates that exposure to light at night (LAN) suppresses melatonin, whose production is known to slow the development of cancerous cells, while another proposes that circadian disruption associated with shift work, and not just LAN, increases health risks. Read More

    Hormonal and Neuromuscular Responses to Breastfeeding: A Pilot Study.
    Biol Res Nurs 2017 Jul 9;19(4):399-408. Epub 2017 Mar 9.
    5 School of Exercise and Nutritional Sciences, San Diego State University, CA, USA.
    Objectives: Difficult breastfeeding in the first weeks after birth may result in muscle tension in infants and activation of the maternal hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS). Our primary objective was to examine the feasibility of collecting neuroendocrine markers of maternal HPA axis and SNS activation (salivary cortisol and α-amylase [sAA]) and electromyographic (EMG) markers of infant distress during feeding in the first 2 weeks after birth. We also examined the relationships of these indices to each other and to mother-infant interactive behaviors during feeding. Read More

    Sleep Quality Associated With Different Work Schedules: A Longitudinal Study of Nursing Staff.
    Biol Res Nurs 2017 Jul 15;19(4):375-381. Epub 2017 Mar 15.
    1 School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
    Purpose: To explore the differences in sleep parameters between nurses working a slow, forward rotating shift and those working a fixed day shift.

    Method: A longitudinal parallel-group comparison design was used in this prospective study. Participants (female) were randomly assigned to a rotating shift or a fixed day shift group. Read More

    The Relationships Between BNP and Neurocardiac Injury Severity, Noninvasive Cardiac Output, and Outcomes After Aneurysmal Subarachnoid Hemorrhage.
    Biol Res Nurs 2017 Oct 19;19(5):531-537. Epub 2017 Jun 19.
    4 School of Nursing, University of Jordan, Amman, Jordan.
    Introduction: Neurocardiac injury, a type of myocardial dysfunction associated with neurological insult to the brain, occurs in 31-48% of aneurysmal subarachnoid hemorrhage (aSAH) patients. Cardiac troponin I (cTnI) is commonly used to diagnose neurocardiac injury. Brain natriuretic peptide (BNP), another cardiac marker, is more often used to evaluate degree of heart failure. Read More

    Measuring Stress in Young Children Using Hair Cortisol: The State of the Science.
    Biol Res Nurs 2017 Oct 15;19(5):499-510. Epub 2017 Jun 15.
    1 College of Nursing, The Ohio State University, Columbus, OH, USA.
    Extensive literature suggests that adverse experiences in early childhood may deleteriously impact later health. These effects are thought to be related to the impact of persistent or chronic stress on various biological processes, mediated by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and ultimately irregularities in cortisol levels. Ameliorating persistent stress in young children requires accurately measuring the chronicity of physiologic stress, which is difficult in young children because of unreliable self-report and the burden and inaccuracy associated with using invasive acute-stress biomeasures. Read More

    Primer in Genetics and Genomics, Article 4-Inheritance Patterns.
    Biol Res Nurs 2017 Jul 22;19(4):465-472. Epub 2017 May 22.
    1 College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA.
    Since the completion of the Human Genome Project, much has been uncovered about inheritance of various illnesses and disorders. There are two main types of inheritance: Mendelian and non-Mendelian. Mendelian inheritance includes autosomal dominant, autosomal recessive, X-linked, and Y-linked inheritance. Read More

    Conducting Biobehavioral Research in Patients With Advanced Cancer: Recruitment Challenges and Solutions.
    Biol Res Nurs 2017 Oct 16;19(5):481-490. Epub 2017 May 16.
    2 School of Nursing, University of Maryland, Baltimore, MD, USA.
    Despite significant advances in cancer treatment and symptom management interventions over the last decade, patients continue to struggle with cancer-related symptoms. Adequate baseline and longitudinal data are crucial for designing interventions to improve patient quality of life and reduce symptom burden; however, recruitment of patients with advanced cancer in longitudinal research is difficult. Our purpose is to describe challenges and solutions to recruitment of patients with advanced cancer in two biobehavioral research studies examining cancer-related symptoms. Read More

    A Randomized Controlled Trial of the Effects of Mindfulness-Based Stress Reduction (MBSR[BC]) on Levels of Inflammatory Biomarkers Among Recovering Breast Cancer Survivors.
    Biol Res Nurs 2017 Jul 1;19(4):456-464. Epub 2017 May 1.
    8 Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
    Purpose: The purpose of this substudy of a large randomized controlled trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction (Breast Cancer) (MBSR[BC]) program compared to usual care (UC) in normalizing blood levels of pro-inflammatory cytokines among breast cancer survivors (BCS).

    Method: A total of 322 BCS were randomized to either a 6-week MBSR(BC) program or a UC. At baseline and 6 and 12 weeks, 10 ml of venous blood and demographic and clinical data were collected and/or updated. Read More

    The Effect of Epidural Analgesia Alone and in Association With Other Variables on the Risk of Cesarean Section.
    Biol Res Nurs 2017 Jul 23;19(4):393-398. Epub 2017 Apr 23.
    3 Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain.
    Introduction: Epidural analgesia (EA) is the most widespread pharmacologic method of labor pain relief. There remains disagreement, however, regarding its adverse effects. The objective of this study was to determine the effect of EA administration on the risk of cesarean delivery and its causes (e. Read More

    Comparison of Hemodynamic Responses in the Prefrontal Cortex According to Differences in Self-Efficacy.
    Biol Res Nurs 2017 Jul 23;19(4):450-455. Epub 2017 Apr 23.
    1 Department of Occupational Therapy, School of Health Science and Social Welfare, Kibi International University, Takahashi, Okayama, Japan.
    Although self-efficacy has been used extensively in the field of nursing (e.g., as an outcome measure of nursing interventions), its underlying nature is poorly understood. Read More

    Association of Exclusive Breastfeeding Duration With Systemic Inflammation Markers in Adolescents: A Cross-Sectional Study.
    Biol Res Nurs 2017 Jul 21;19(4):419-427. Epub 2017 Apr 21.
    2 Instituto de la Grasa-CSIC, Campus Universidad Pablo de Olavide, Seville, Spain.
    Background: Breastfeeding duration has been associated with less low-grade inflammation in healthy adolescents, but there is scarce information regarding obese subjects. This study aimed to evaluate whether exclusive breastfeeding is related to serum concentrations of inflammatory markers in a population of Spanish adolescents.

    Method: A cross-sectional study was performed on 1,001 adolescents (13. Read More

    Primer in Genetics and Genomics, Article 3-Explaining Human Diversity: The Role of DNA.
    Biol Res Nurs 2017 May 14;19(3):350-356. Epub 2017 Mar 14.
    1 Boston College, William F. Connell School of Nursing, Chestnut Hill, MA, USA.
    Genetic variation lays the foundation for diversity and enables humans to adapt to changing environments. The order of the nucleotides adenine, guanine, cytosine, and thymine on the deoxyribonucleic acid (DNA) molecules of the nuclear chromosomes and mitochondrial DNA (mtDNA) plays an important role in normal cell division, tissue development, and reproduction but is susceptible to alteration from a large number of random, inherited, or environmental events. Variations can range from a change in a single nucleotide to duplication of entire chromosomes. Read More

    Glucose Variations and Activity Are Strongly Coupled in Sleep and Wake in Young Adults With Type 1 Diabetes.
    Biol Res Nurs 2017 May 20;19(3):249-257. Epub 2016 Dec 20.
    3 Department of Biobehavioral Health Science, University of Illinois at Chicago, Chicago, IL, USA.
    Background: Glucose variations are common throughout sleep and wakefulness in people with type 1 diabetes mellitus (T1DM). The objective of this investigation was to characterize the time-varying coupling between glucose and unstructured physical activity over a 60-hr period in young adults with T1DM. The hypothesis was that coupling would differ during sleep versus wakefulness and would exhibit circadian variations. Read More

    Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.
    Biol Res Nurs 2017 May 13;19(3):339-349. Epub 2017 Mar 13.
    1 College of Nursing, The University of Iowa, Iowa City, IA, USA.
    Objective: This study used a candidate gene approach to examine genomic variation associated with pain, anxiety, and distress in children undergoing a medical procedure.

    Study Design: Children aged 4-10 years having an IV catheter insertion were recruited from three Midwestern children's hospitals. Self-report measures of pain, anxiety, and distress were obtained as well as an observed measure of distress. Read More

    Associations of Maternal Testosterone and Cortisol Levels With Health Outcomes of Mothers and Their Very-Low-Birthweight Infants.
    Biol Res Nurs 2017 Jul 12;19(4):409-418. Epub 2017 Apr 12.
    1 School of Nursing, Duke University, Durham, NC, USA.
    Objective: Although the roles of testosterone and cortisol in various health problems have been extensively investigated, little is known about their associations with health outcomes in mothers and their very-low-birthweight (VLBW) infants when maternal testosterone and cortisol are examined together during the postpartum period.

    Method: The 101 mother-VLBW infant pairs were recruited from the neonatal intensive care unit of a tertiary medical center in the southeastern United States. Demographic information, pregnancy and labor complications of mothers, and health and growth outcomes of infants were obtained from medical records and interviews with mothers. Read More

    Cumulative Risk and Physiological Stress Responses in African American Adolescents.
    Biol Res Nurs 2017 Jul 4;19(4):428-439. Epub 2017 Apr 4.
    2 Department of Adult Health and Nursing Systems, School of Nursing, Virginia Commonwealth University, Richmond, VA, USA.
    Objective: To investigate associations between components of cumulative risk (CR) and physiological stress responses in African American adolescents and evaluate emotion regulation as a mediator and sex as a moderator of these associations.

    Methods: Cortisol and salivary alpha amylase (sAA) were collected in adolescents ( N = 205; 55% female; 12.1 ± 1. Read More

    Testing a Resilience Training Program in Police Recruits: A Pilot Study.
    Biol Res Nurs 2017 Jul 30;19(4):440-449. Epub 2017 Mar 30.
    1 College of Nursing, University of Iowa, Iowa City, IA, USA.
    Background: Stress from multiple sources is inherent in law enforcement. However, it is possible to modify responses to stress with resilience training that includes teaching techniques to modify emotional and physical responses to stress, interface with mental health professionals, and practice sessions to improve self-regulation of responses to stress including coherence, a measure of heart rate variability. A gap exists in the research, however, regarding evaluation of the duration of effects after the initial resilience training. Read More

    Oxytocin Augmentation in Spontaneously Laboring, Nulliparous Women: Multilevel Assessment of Maternal BMI and Oxytocin Dose.
    Biol Res Nurs 2017 Jul 28;19(4):382-392. Epub 2017 Mar 28.
    2 College of Nursing, University of Colorado, Aurora, CO, USA.
    Background: Synthetic oxytocin, the primary tool for labor augmentation, is less effective among obese women, leading to more unplanned cesarean deliveries for slow labor progress. It is not known if obese women require higher doses of oxytocin due to maternal, fetal, or labor factors related to maternal obesity.

    Objectives: This study had two main objectives: (1) examine the influence of maternal body mass index (BMI) on hourly doses of oxytocin from augmentation initiation until vaginal delivery in obese women; and (2) examine the influence of other maternal, fetal, and labor factors on hourly doses of oxytocin in obese women. Read More

    Variations in COMT and NTRK2 Influence Symptom Burden in Women Undergoing Breast Cancer Treatment.
    Biol Res Nurs 2017 May 16;19(3):318-328. Epub 2017 Feb 16.
    3 University of Florida College of Nursing, Gainesville, FL, USA.
    Women with breast cancer frequently report distressing symptoms during and after treatment that can significantly erode quality of life (QOL). Symptom burden among women with breast cancer is of complex etiology and is likely influenced by disease, treatment, and environmental factors as well as individual genetic differences. The purpose of the present study was to examine the relationships between genetic polymorphisms within Neurotrophic tyrosine kinase receptor 1 (NTRK1), Neurotrophic tyrosine kinase receptor 2 (NTRK2), and catechol-O-methyltransferase ( COMT) and patient symptom burden of QOL, pain, fatigue, anxiety, depression, and sleep disturbance before, during, and after treatment for breast cancer in a subset of participants ( N = 51) in a randomized clinical trial of a novel symptom-management modality for women with breast cancer undergoing chemotherapy. Read More

    Roux-en-Y Gastric Bypass.
    Biol Res Nurs 2017 Mar 29;19(2):162-169. Epub 2016 Nov 29.
    3 Department of Food Technology and Nutrition, Catholic University of San Antonio, Murcia, Spain.
    Background: Roux-en-Y gastric bypass (RYGB) is considered the gold standard for gastric bypass, displaying better results for metabolic disorders than other surgical procedures over the long term. The aim of this study was to determine the effects of bariatric surgery, in particular the RYGB technique, on metabolic syndrome (MS) and other biochemical parameters implicit in the comorbid conditions associated with obesity, as well as to explore the influence of this surgical procedure on psychiatric comorbidity in the study population.

    Method: An observational retrospective cohort study based on 146 clinical records of patients having undergone RYGB between January 1, 2011, and January 1, 2014, was performed. Read More

    Comparative Evaluation of Pain, Stress, Neuropeptide Y, ACTH, and Cortisol Levels Between a Conventional Postoperative Care Protocol and a Fast-Track Recovery Program in Patients Undergoing Major Abdominal Surgery.
    Biol Res Nurs 2017 Mar 20;19(2):180-189. Epub 2016 Dec 20.
    4 Department of Nursing, National and Kapodistrian University of Athens, Athens, Greece.
    Background: Fast-track (FT) postoperative protocol in oncological patients after major abdominal surgery reduces complications and length of postoperative stay compared to the conventional (CON) protocol. However, stress and pain responses have not been compared between the two protocols.

    Objectives: To compare stress, pain, and related neuropeptidic responses (adrenocorticotropic hormone [ACTH], cortisol, and neuropeptide Y [NPY]) between FT and CON protocols. Read More

    Neurocognitive Function Is Associated With Serum Iron Status in Early Adolescents.
    Biol Res Nurs 2017 May 15;19(3):269-277. Epub 2017 Feb 15.
    1 School of Nursing University of Pennsylvania, Philadelphia, PA, USA.
    Objective: The association between iron and neurocognition remains underexplored in adolescents, and the neurocognitive effects of low and high iron levels have yet to be established. The aim of this study was to investigate the relationships of low and high iron levels with neurocognitive domains in early adolescents.

    Method: The sample comprised 428 adolescents (12. Read More

    IL-10 Gene Polymorphisms and Self-Medication With Over-the-Counter Nonsteroidal Anti-Inflammatory Drugs.
    Biol Res Nurs 2017 May 30;19(3):329-338. Epub 2017 Jan 30.
    1 School of Nursing, University of Connecticut, Storrs, CT, USA.
    Background: Genetic influences on self-medication with over-the-counter (OTC) drugs merit investigation. For example, patients frequently use OTC nonsteroidal anti-inflammatory drugs (NSAIDs) to treat inflammation, but the inflammatory response is also affected by endogenous cytokines whose production varies across polymorphisms of their encoding genes. In the case of interleukin 10 (IL-10), literature suggests that a single nucleotide polymorphism (SNP) in the promoter region of the cytokine's gene (-1082 A > G [rs1800896]) influences production with higher levels associated with G variant alleles. Read More

    Primer in Genetics and Genomics, Article 2-Advancing Nursing Research With Genomic Approaches.
    Biol Res Nurs 2017 Mar 30;19(2):229-239. Epub 2017 Jan 30.
    2 National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
    Purpose: Nurses investigate reasons for variable patient symptoms and responses to treatments to inform how best to improve outcomes. Genomics has the potential to guide nursing research exploring contributions to individual variability. This article is meant to serve as an introduction to the novel methods available through genomics for addressing this critical issue and includes a review of methodological considerations for selected genomic approaches. Read More

    The Successful Immediate Neonatal Transition to Extrauterine Life.
    Biol Res Nurs 2017 May 12;19(3):287-294. Epub 2017 Jan 12.
    1 College of Nursing, University of Colorado, Denver, CO, USA.
    Purpose: To define and describe the processes underlying the successful neonatal transition to extrauterine life and methods to assess the transition.

    Method: Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase, Web of Science, and Google Scholar were searched using a combination of the key words neonate, neonatal, newborn, transition, respiratory OR pulmonary, cardiac, metabolic, pH, umbilical cord, and assessment. Articles in English and German were reviewed. Read More

    The Microbiome and Complement Activation: A Mechanistic Model for Preterm Birth.
    Biol Res Nurs 2017 May 11;19(3):295-307. Epub 2017 Jan 11.
    1 Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
    Preterm birth (PTB, <37 completed weeks' gestation) is one of the leading obstetrical problems in the United States, affecting approximately one of every nine births. Even more concerning are the persistent racial disparities in PTB, with particularly high rates among African Americans. There are several recognized pathophysiologic pathways to PTB, including infection and/or exaggerated systemic or local inflammation. Read More

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