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    777 results match your criteria Biological Research For Nursing [Journal]

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    Positive Effects of a Short-Term Intense Elastic Resistance Training Program on Body Composition and Physical Functioning in Overweight Older Women.
    Biol Res Nurs 2018 Jan 1:1099800418757676. Epub 2018 Jan 1.
    2 Research Group in Prevention and Health in Exercise and Sport, University of Valencia, Valencia, Spain.
    The aim of this study was to investigate the effects of a resistance training program (RTP) in older overweight women (OOW) using two different types of elastic devices.

    Methods: This study was a randomized controlled trial with pre- and postintervention measures. Participants included OOW, aged 60-85 years, with no medical history of disease that would preclude them from engaging in physical exercise. Read More

    The Effects of Enriched Environmental Intervention on the Parturition Outcome and Filial Health of Pregnant Mice With Chronic Pain.
    Biol Res Nurs 2018 Jan 1:1099800418754303. Epub 2018 Jan 1.
    1 School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, China.
    Chronic pain (CP) adversely impacts people's health. However, the influence of CP on pregnant women and their fetuses remains unclear. Few reasonable interventions have been offered to these women. Read More

    Perceived Stress, Its Physiological Correlates, and Quality of Life in Patients With Irritable Bowel Syndrome.
    Biol Res Nurs 2018 Jan 1:1099800418756733. Epub 2018 Jan 1.
    2 Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
    Irritable bowel syndrome (IBS) is a chronic, common disorder of the gastrointestinal tract associated with high psychological comorbidity and diminished quality of life. Patients with IBS display a heightened sensitivity to stress, although the literature is inconsistent as to whether they have a dysregulated stress response. The purpose of the present investigation, a substudy of a larger research effort, was to examine physiological correlates of perceived stress in patients with IBS (cortisol and adrenocorticotropic hormone) and to explore associations between perceived stress and quality of life. Read More

    Epigenetic Modifications Following Noxious Stimuli in Infants.
    Biol Res Nurs 2018 Mar 30;20(2):137-144. Epub 2018 Jan 30.
    5 University of Pittsburgh, Pittsburgh, PA, USA.
    Purpose: To recruit healthy full- and preterm infants into genetic research and determine the effectiveness of a noninvasive DNA sampling technique for comparing epigenetic modifications.

    Background: Noxious stimuli during a vulnerable period of infant neuronal plasticity may trigger long-term epigenetic changes affecting neurodevelopment, pain modulation, and reactivity. Recognizing epigenetic pain findings is problematic because parents are reluctant to enroll newborns into genetic research. Read More

    The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women.
    Biol Res Nurs 2018 Mar 23;20(2):205-217. Epub 2018 Jan 23.
    3 Service of Clinical Analysis, University Hospital Dr. Peset-FISABIO, University of Valencia, Valencia, Spain.
    This study investigated effects of a 16-week progressive resistance training program (RTP) with elastic bands at two different intensities on systemic redox state, DNA damage, and physical function in healthy older women.

    Methods: Participants were randomly assigned to the high-intensity group (HIGH; n = 39), moderate-intensity group (MOD; n = 31), or control group (CG; n = 23). The exercise groups performed an RTP twice a week with three to four sets of 6 (HIGH) or 15 (MOD) repetitions of six overall body exercises at a perceived exertion rate of 8-9 on the OMNI-Resistance Exercise Scale for use with elastic bands. Read More

    Associating Symptom Phenotype and Genotype in Preeclampsia.
    Biol Res Nurs 2018 Mar 22;20(2):126-136. Epub 2018 Jan 22.
    4 University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
    Preeclampsia is a complex genetic disorder with an incompletely understood pathogenesis. Its phenotype may be better elucidated by integrating symptoms. This study aimed to identify symptoms by gestational age and associations with novel preeclampsia candidate genes. Read More

    Delayed Onset of Sleep in Adolescents With PAX6 Haploinsufficiency.
    Biol Res Nurs 2018 Mar 17;20(2):237-243. Epub 2018 Jan 17.
    1 Unit on Metabolism and Neuroendocrinology, Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
    Objective: PAX6 haploinsufficiency ( +/-) can occur due to mutations involving only PAX6 in patients with isolated aniridia or as contiguous gene deletions in patients with Wilms tumor, aniridia, genitourinary anomalies, and range of developmental and intellectual disabilities syndrome. Given the role of PAX6 in pineal development and circadian regulation, adolescents with PAX6+/- may experience sleep-wake disturbances. The purpose of this observational study was to explore sleep-related phenotypes in adolescents with PAX6+/-. Read More

    Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships.
    Biol Res Nurs 2018 Mar 16;20(2):161-167. Epub 2018 Jan 16.
    5 Rory Meyers College of Nursing, New York University, New York, NY, USA.
    Introduction: Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Read More

    Polymorphisms in Estrogen Synthesis Genes and Symptom Clusters During the Menopausal Transition and Early Postmenopause: Observations From the Seattle Midlife Women's Health Study.
    Biol Res Nurs 2018 Mar 15;20(2):153-160. Epub 2018 Jan 15.
    4 Department of Sociology, University of Washington, Seattle, WA, USA.
    During the menopausal transition and early postmenopause, participants in the Seattle Midlife Women's Health Study (SMWHS) experienced one of the three symptom severity clusters identified through latent class analysis: severe hot flashes with moderate sleep, mood, cognitive, and pain symptoms (high-severity hot flash); low-severity hot flashes with moderate levels of all other symptom groups (moderate severity); and low levels of all symptom groups (low severity). In an effort to determine whether gene polymorphisms were associated with these symptom severity classes, we tested associations between gene polymorphisms in the estrogen synthesis pathways (cytochrome P450 19 [CYP 19] and 17 beta hydroxysteroid dehydrogenase [ 17HSDB1]) and the three symptom severity clusters. SMWHS participants ( N = 137) recorded symptoms monthly in diaries and provided buccal smears for genotyping. Read More

    Inherited Cancer in the Age of Next-Generation Sequencing.
    Biol Res Nurs 2018 Mar 11;20(2):192-204. Epub 2018 Jan 11.
    1 Counsyl, South San Francisco, CA, USA.
    Next-generation sequencing (NGS) technology has led to the ability to test for multiple cancer susceptibility genes simultaneously without significantly increasing cost or turnaround time. With growing usage of multigene testing for inherited cancer, ongoing education for nurses and other health-care providers about hereditary cancer screening is imperative to ensure appropriate testing candidate identification, test selection, and posttest management. The purpose of this review article is to (1) provide an overview of how NGS works to detect germline mutations, (2) summarize the benefits and limitations of multigene panel testing, (3) describe risk categories of cancer susceptibility genes, and (4) highlight the counseling considerations for patients pursuing multigene testing. Read More

    Expression of Sestrin Genes in Radiotherapy for Prostate Cancer and Its Association With Fatigue: A Proof-of-Concept Study.
    Biol Res Nurs 2018 Mar 11;20(2):218-226. Epub 2018 Jan 11.
    5 Symptoms Biology Unit, NINR/NIH, Bethesda, MD, USA.
    Genetic factors that influence inflammation and energy production/expenditure in cells may affect patient outcomes following treatment with external beam radiation therapy (EBRT). Sestrins, stress-inducible genes with antioxidant properties, have recently been implicated in several behaviors including fatigue. This proof-of-concept study explored whether the sestrin family of genes ( SESN1, SESN2, and SESN3) were differentially expressed from baseline to the midpoint of EBRT in a sample of 26 Puerto Rican men with nonmetastatic prostate cancer. Read More

    Symptom Science: Omics Supports Common Biological Underpinnings Across Symptoms.
    Biol Res Nurs 2018 Mar 11;20(2):183-191. Epub 2018 Jan 11.
    1 University of Pittsburgh School of Nursing, Pittsburgh, PA, USA.
    For precision health care to be successful, an in-depth understanding of the biological mechanisms for symptom development and severity is essential. Omics-based research approaches facilitate identification of the biological underpinnings of symptoms. We reviewed literature for omics-based approaches and exemplar symptoms (sleep disruption, cognitive impairment, fatigue, gastrointestinal [GI] distress, and pain) to identify genes associated with the symptom or symptoms across disease processes. Read More

    Effects of Gender-Specific Differences, Inflammatory Response, and Genetic Variation on the Associations Among Depressive Symptoms and the Risk of Major Adverse Coronary Events in Patients With Acute Coronary Syndrome.
    Biol Res Nurs 2018 Mar 3;20(2):168-176. Epub 2018 Jan 3.
    1 The University of Texas Health Science Center at Houston, Cizik School of Nursing, Houston, TX, USA.
    Depressive symptoms independently contribute to major adverse coronary events (MACEs), with the biological immune response to depression being a likely mediator of this relationship. To determine whether genetic- and/or gender-specific phenotypic differences contribute to associations among depressive symptoms, inflammatory response, and risk of MACE in patients with acute coronary syndrome (ACS), we conducted a prospective study of 1,117 ACS patients to test a gender-specific model in which depressive symptoms (Beck Depression Inventory-II [BDI-II]) are associated with risk of MACE. Cox proportional hazards models were used to model time to incident MACE and determine whether single-nucleotide polymorphisms (SNPs) in specific inflammatory protein-coding genes and depressive symptoms interact to influence levels of inflammatory proteins or risk of MACE. Read More

    Evaluation of APOE Genotype and Ability to Perform Activities of Daily Living Following Aneurysmal Subarachnoid Hemorrhage.
    Biol Res Nurs 2018 Mar 19;20(2):177-182. Epub 2017 Dec 19.
    1 School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
    Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often experience unfavorable functional outcomes that result in a reduced ability to independently perform activities of daily living. The apolipoprotein E gene ( APOE) encodes for a protein known to facilitate lipid transport and aid in neuronal repair within the central nervous system and to moderate the inflammatory response, making functional variations in this gene likely candidate biomarkers to predict outcomes following aSAH. In the present work, we examined the relationship between APOE genotype and the ability to perform activities of daily living as measured by the Barthel Index (BI) score at 3 months ( n = 298) and 12 months ( n = 288) following aSAH. Read More

    Perceived Racial Discrimination and DNA Methylation Among African American Women in the InterGEN Study.
    Biol Res Nurs 2018 Mar 19;20(2):145-152. Epub 2017 Dec 19.
    1 Yale School of Nursing, Orange, CT, USA.
    Introduction: Experiences of racial discrimination have been associated with poor health outcomes. Little is known, however, about how perceived racial discrimination influences DNA methylation (DNAm) among African Americans (AAs). We examined the association of experiences of discrimination with DNAm among AA women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) study. Read More

    Pilot Study of Metabolomics and Psychoneurological Symptoms in Women With Early Stage Breast Cancer.
    Biol Res Nurs 2018 Mar 19;20(2):227-236. Epub 2017 Dec 19.
    7 Virginia Commonwealth University, Richmond, VA, USA.
    Many women with breast cancer experience symptoms of pain, fatigue, and depression, collectively known as psychoneurologic (PN) symptoms, during and after chemotherapy treatment. Evidence that inflammatory dysfunction related to cancer and its treatments contributes to the development and persistence of PN symptoms through several interrelated pathways is accumulating. However, a major limiting factor in more precisely identifying the biological mechanisms underlying these symptoms is the lack of biological measures that represent a holistic spectrum of biological responses. Read More

    Primer in Genetics and Genomics, Article 6: Basics of Epigenetic Control.
    Biol Res Nurs 2018 Jan 23;20(1):103-110. Epub 2017 Nov 23.
    2 Rory Meyers College of Nursing, New York, NY, USA.
    The epigenome is a collection of chemical compounds that attach to and overlay the DNA sequence to direct gene expression. Epigenetic marks do not alter DNA sequence but instead allow or silence gene activity and the subsequent production of proteins that guide the growth and development of an organism, direct and maintain cell identity, and allow for the production of primordial germ cells (PGCs; ova and spermatozoa). The three main epigenetic marks are (1) histone modification, (2) DNA methylation, and (3) noncoding RNA, and each works in a different way to regulate gene expression. Read More

    An Exploration of the Determinants of Gestational Weight Gain in African American Women: Genetic Factors and Energy Expenditure.
    Biol Res Nurs 2018 Mar 21;20(2):118-125. Epub 2017 Nov 21.
    2 School of Nursing, University of Rochester, Rochester, NY, USA.
    Background: Excessive gestational weight gain (GWG) has a long-term impact on women's body weight and contributes to the development of obesity in the mother and her child. Many risk factors for GWG have been identified, but to date, only 6-33.8% of the variance in GWG has been explained. Read More

    Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
    Biol Res Nurs 2017 Jan 1:1099800417738363. Epub 2017 Jan 1.
    4 Mood and Anxiety Program, University of Maryland, Baltimore, MD, USA.
    Objective: To evaluate relationships among obesity in pregnancy and plasma levels of tryptophan (TRP) and kynurenine (KYN), inflammatory markers, and depressed mood.

    Methods: Pregnant women ( N = 374) were enrolled, and data were collected at a mean gestation of 20 weeks in this cross-sectional study. Plasma was analyzed for TRP, KYN, neopterin, and nitrite levels. Read More

    Determining Psychoneuroimmunologic Markers of Yoga as an Intervention for Persons Diagnosed With PTSD: A Systematic Review.
    Biol Res Nurs 2017 Jan 1:1099800417739152. Epub 2017 Jan 1.
    2 Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA, USA.
    There is a growing body of research on yoga as a therapeutic intervention for psychological symptoms of post-traumatic stress disorder (PTSD) accompanied by speculations on underlying physiologic mechanisms. The purpose of this systematic review is to identify, qualitatively evaluate, and synthesize studies of yoga as an intervention for PTSD that measured physiologic outcomes in order to gain insights into potential mechanisms. The focus is on studies evaluating yoga as a therapeutic intervention for PTSD rather than for trauma exposure, PTSD prevention, or subclinical PTSD. Read More

    The Role of Biomarkers in Research on Caregivers for Cancer Patients: A Scoping Review.
    Biol Res Nurs 2017 Jan 1:1099800417740970. Epub 2017 Jan 1.
    1 National Institutes of Health Clinical Center, Bethesda, MD, USA.
    Background: Biomarkers can be used as prognostic, predictive, or monitoring indicators of an associated outcome. The purpose of this review was to provide a comprehensive summary of the research examining the use of biomarkers as surrogate end points for clinical outcomes in family caregivers for cancer patients, identify gaps, and make recommendations for future research.

    Methods: A scoping review, a process of mapping the existing literature, was conducted. Read More

    Arterial Stiffness Is Associated With QTc Interval Prolongation in Patients With Heart Failure.
    Biol Res Nurs 2017 Jan 1:1099800417737835. Epub 2017 Jan 1.
    4 University of Calgary in Qatar, Qatar.
    Background: A prolonged corrected QT (QTc) interval is a known risk factor for adverse cardiac events. Understanding the determinants and physiologic correlates of QTc is necessary for selecting proper strategies to reduce the risk of adverse events in high-risk patients. We sought to evaluate the role of arterial stiffness in heart failure as a determinant of QTc prolongation. Read More

    Serum BDNF Is Positively Associated With Negative Symptoms in Older Adults With Schizophrenia.
    Biol Res Nurs 2018 Jan 19;20(1):63-69. Epub 2017 Oct 19.
    2 Department of Physiological Nursing, University of California, San Francisco, CA, USA.
    Objectives: Older adults with chronic schizophrenia are at greater risk for functional disability and poorer health outcomes than those without serious mental illness. These individuals comprise 1-2% of the elderly population in the United States and are projected to number approximately 15 million by 2030. The symptoms of schizophrenia can be disabling for individuals, significantly reducing quality of life. Read More

    Increase in Oxytocin From Skin-to-Skin Contact Enhances Development of Parent-Infant Relationship.
    Biol Res Nurs 2018 Jan 11;20(1):54-62. Epub 2017 Oct 11.
    1 School of Nursing, University of Connecticut, Storrs, CT, USA.
    Objective: To examine changes that occur in infant and parent salivary oxytocin (OT) and salivary cortisol (SC) levels during skin-to-skin contact (SSC) and whether SSC alleviates parental stress and anxiety while also supporting mother-father-infant relationships.

    Methods: This randomized crossover study was conducted in the neonatal intensive care unit (NICU) with a sample of 28 stable preterm infants and their parents. Saliva samples were collected from infants, mothers, and fathers on Days 1 and 2 (1/parent) for OT and cortisol measurement pre-SSC, during a 60-min SSC session, and a 45-min post-SSC. Read More

    Oxytocin Levels in Community-Collected Saliva Samples Transported by Dry Versus Wet Ice.
    Biol Res Nurs 2018 Jan 11;20(1):49-53. Epub 2017 Oct 11.
    1 Beyster Institute for Nursing Research, Hahn School of Nursing and Health Science, University of San Diego, San Diego, CA, USA.
    Oxytocin (OT), a neuropeptide produced primarily in the hypothalamus, is associated with both critical physiological and psychological processes, particularly stress and feelings of affiliation. Increasingly, researchers are seeking ways to reliably incorporate OT as an outcome biomarker in clinical research. Previously, OT levels were measured in plasma or urine. Read More

    Clinical Relevance of Gastrointestinal Microbiota During Pregnancy: A Primer for Nurses.
    Biol Res Nurs 2018 Jan 27;20(1):84-102. Epub 2017 Sep 27.
    3 School of Nursing, University of Maryland, Baltimore, MD, USA.
    Emerging evidence about the human microbiome, a collective term for all the microorganisms living in and on the human body, consistently demonstrates the critical influence it has on host physiology and disease risk. The microbiota in the gastrointestinal (GI) tract has the most significant and far-reaching effect on human physiology. The maternal GI microbiota can decrease the risk of adverse pregnancy outcomes by modulating energy extraction, glucose metabolism, vitamin production, and host immunity essential for optimal maternal and neonatal health. Read More

    Antidepressive Effects of Environmental Enrichment in Chronic Stress-Induced Depression in Rats.
    Biol Res Nurs 2018 Jan 21;20(1):40-48. Epub 2017 Sep 21.
    5 East-West Nursing Research Institute, College of Nursing Science, Kyung Hee University, Seoul, Republic of Korea.
    Depression is caused by a variety of factors, especially stressful life events. Chronic stress-induced depression has detrimental effects on hippocampal integrity. Environmental enrichment (EE) is a beneficial intervention for improving anxiety, fear, and stress. Read More

    Characteristics of Tables for Disseminating Biobehavioral Results.
    Biol Res Nurs 2018 Jan 20;20(1):70-76. Epub 2017 Sep 20.
    1 School of Nursing, University of Nevada, Las Vegas, NV, USA.
    Background: To report the complexity and richness of study variables within biological nursing research, authors often use tables; however, the ease with which consumers understand, synthesize, evaluate, and build upon findings depends partly upon table design.

    Objectives: To assess and compare table characteristics within research and review articles published in Biological Research for Nursing and Nursing Research.

    Method: A total of 10 elements in tables from 48 biobehavioral or biological research or review articles were analyzed. Read More

    Primer in Genetics and Genomics, Article 5-Further Defining the Concepts of Genotype and Phenotype and Exploring Genotype-Phenotype Associations.
    Biol Res Nurs 2017 Oct;19(5):576-585
    2 Scientific Project Leader, Flatiron Health, New York, NY, USA.
    As nurses begin to incorporate genetic and genomic sciences into clinical practice, education, and research, it is essential that they have a working knowledge of the terms foundational to the science. The first article in this primer series provided brief definitions of the basic terms (e.g. Read More

    Spatial Learning Responses to Lipopolysaccharide in Adult and Aged Rats.
    Biol Res Nurs 2018 Jan 11;20(1):32-39. Epub 2017 Sep 11.
    2 School of Nursing, University of Michigan, Ann Arbor, MI, USA.
    Sickness behaviors, adaptive responses to infections, include lethargy, depression, reduced eating and grooming, and concentration problems resulting from interactions between the immune and neuroendocrine systems. Detecting these responses is especially critical in the elderly, as the infections that cause them can lead to cognitive impairment. While deficits in spatial learning, a hippocampal-dependent form of learning, are part of the sickness response, directional heading errors (DHEs; an indicator of spatial-learning deficits) and their time trajectories need further examination. Read More

    Differences Between Sleep Logs and Actigraphy Combined With Electroencephalography in Adults With Sleep Disturbances.
    Biol Res Nurs 2018 Jan 4;20(1):77-83. Epub 2017 Sep 4.
    4 Department of Nursing, Tzu Chi University, Hualien, Taiwan.
    Background: Actigraphy plus single-channel electroencephalography (EEG) has a high agreement with polysomnography and is considered a simple method for monitoring sleep at home. No studies, however, have evaluated its agreement with sleep logs.

    Purpose: A sleep log was compared to a single-channel EEG in adults with sleep disturbances. Read More

    Factors That Influence Blood Pressure in 3- to 5-Year-Old Children: A Pilot Study.
    Biol Res Nurs 2018 Jan 29;20(1):25-31. Epub 2017 Aug 29.
    1 School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
    While incident elevations in blood pressure (BP) are apparent in preschool years, factors influencing BP in this population have received little attention. The purposes of this pilot study were to determine the feasibility of collecting data from preschoolers and their mothers and to determine effect sizes of relationships between BP and sex, race, birth status, body mass index (BMI), waist circumference (WC), geographic location, serum C-reactive protein (CRP), and salivary cortisol (morning, afternoon). A hypothesis-generating correlational design was used; 56 children, aged 3-5 years, were enrolled from six rural and urban Head Start programs in a southeastern state. Read More

    Searching for Evidence of an Anti-Inflammatory Diet in Children: A Systematic Review of Randomized Controlled Trials for Pediatric Obesity Interventions With a Focus on Leptin, Ghrelin, and Adiponectin.
    Biol Res Nurs 2017 Oct 26;19(5):511-530. Epub 2017 Jul 26.
    1 School of Nursing, The University of Texas at Austin, Austin, TX, USA.
    Problem: To address the complex phenomenon of pediatric obesity, one must understand the physiological mechanisms regulating energy intake and inflammation. The peptide hormones leptin, ghrelin, and adiponectin are involved in both, but their functions are dysregulated in obesity. The purpose of this systematic review is (1) to characterize studies of nutrition interventions for weight management in children who measure these peptides as outcomes, (2) to assess risk of bias in the studies, and (3) to determine the relationships between these peptides and body mass index (BMI). Read More

    Long-Term Effects of Prematurity, Cumulative Medical Risk, and Proximal and Distal Social Forces on Individual Differences in Diurnal Cortisol at Young Adulthood.
    Biol Res Nurs 2018 Jan 24;20(1):5-15. Epub 2017 Jul 24.
    3 Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, USA.
    This study examined the effects of prematurity, cumulative medical risk, and proximal and distal social forces on individual differences in the activity of the hypothalamic-pituitary-adrenal (HPA) axis in young adulthood. A prospective sample of 149 infants born healthy preterm (PT; n = 22), sick PT ( n = 93, medical illness, neurological illness, small for gestational age), and full term ( n = 34) was recruited from a Level III neonatal intensive care unit in southern New England between 1985 and 1989 and followed to age 23 years. Cumulative medical risk was indexed across seven assessment waves (spanning 17 years) using medical and neurological health status at birth, toddlerhood (ages 18 and 30 months), childhood (ages 4 and 8 years), and adolescence (ages 12 and 17 years). Read More

    Quantitative Sensory Testing and Current Perception Threshold Testing in Patients With Chronic Pain Following Lower Extremity Fracture.
    Biol Res Nurs 2018 Jan 24;20(1):16-24. Epub 2017 Jul 24.
    3 School of Nursing, University of Maryland, Baltimore, MD, USA.
    Background: Chronic pain is a significant problem for patients with lower extremity injuries. While pain hypersensitivity has been identified in many chronic pain conditions, it is not known whether patients with chronic pain following lower extremity fracture report pain hypersensitivity in the injured leg.

    Purpose: To quantify and compare peripheral somatosensory function and sensory nerve activation thresholds in persons with chronic pain following lower extremity fractures with a cohort of persons with no history of lower extremity fractures. Read More

    From Donor to Recipient: Considerations for Blood Transfusion Outcomes Research.
    Biol Res Nurs 2017 Oct 17;19(5):491-498. Epub 2017 Jul 17.
    1 School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
    Donated blood can be broken down into blood components for use in patient care. This article focuses primarily on packed red blood cells (PRBCs), as they experience breakdown during storage that may adversely impact patient outcomes. Patients require PRBC transfusions for a number of clinical reasons. Read More

    Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization.
    Biol Res Nurs 2017 Oct 12;19(5):549-558. Epub 2017 Jul 12.
    2 The Ohio State University College of Nursing, Columbus, OH, USA.
    Extremely premature infants are at great risk for poor neurodevelopmental outcomes, in part because neurologic structures designed to mature in the womb must now do so in the extrauterine environment. Reliable biomarkers of neurodevelopment are especially critical in this population, as behavioral measures can be unreliable due to immaturity of the premature infant nervous system. Oxytocin (OT) has the potential to be a marker of neurobiological processes that offer infant neuroprotection. Read More

    Genetic Basis of Positive and Negative Symptom Domains in Schizophrenia.
    Biol Res Nurs 2017 Oct 10;19(5):559-575. Epub 2017 Jul 10.
    2 Duke Center for Applied Genomics and Precision Medicine, Duke University School of Nursing, Durham, NC, USA.
    Schizophrenia is a highly heritable disorder, the genetic etiology of which has been well established. Yet despite significant advances in genetics research, the pathophysiological mechanisms of this disorder largely remain unknown. This gap has been attributed to the complexity of the polygenic disorder, which has a heterogeneous clinical profile. Read More

    The Relation Between Physical Activity and Cognitive Change in Older Latinos.
    Biol Res Nurs 2017 Oct 29;19(5):538-548. Epub 2017 Jun 29.
    2 Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
    Cognitive impairment in older Latinos is of concern due to the rapid growth of this population and their increased risk for dementia due to chronic disease. Evidence, primarily from studies of non-Latino Whites, suggests that physical activity (PA) may reduce cognitive decline. Few longitudinal studies have included older Latinos, objective measures of PA, or neurocognitive tests that assess domains of cognition. Read More

    Measuring Light at Night and Melatonin Levels in Shift Workers: A Review of the Literature.
    Biol Res Nurs 2017 07;19(4):365-374
    1 Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, USA.
    Shift work, especially that involving rotating and night shifts, is associated with an increased risk of diseases, including cancer. Attempts to explain the association between shift work and cancer in particular have focused on the processes of melatonin production and suppression. One hypothesis postulates that exposure to light at night (LAN) suppresses melatonin, whose production is known to slow the development of cancerous cells, while another proposes that circadian disruption associated with shift work, and not just LAN, increases health risks. Read More

    Hormonal and Neuromuscular Responses to Breastfeeding: A Pilot Study.
    Biol Res Nurs 2017 07 9;19(4):399-408. Epub 2017 Mar 9.
    5 School of Exercise and Nutritional Sciences, San Diego State University, CA, USA.
    Objectives: Difficult breastfeeding in the first weeks after birth may result in muscle tension in infants and activation of the maternal hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS). Our primary objective was to examine the feasibility of collecting neuroendocrine markers of maternal HPA axis and SNS activation (salivary cortisol and α-amylase [sAA]) and electromyographic (EMG) markers of infant distress during feeding in the first 2 weeks after birth. We also examined the relationships of these indices to each other and to mother-infant interactive behaviors during feeding. Read More

    Sleep Quality Associated With Different Work Schedules: A Longitudinal Study of Nursing Staff.
    Biol Res Nurs 2017 07 15;19(4):375-381. Epub 2017 Mar 15.
    1 School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
    Purpose: To explore the differences in sleep parameters between nurses working a slow, forward rotating shift and those working a fixed day shift.

    Method: A longitudinal parallel-group comparison design was used in this prospective study. Participants (female) were randomly assigned to a rotating shift or a fixed day shift group. Read More

    The Relationships Between BNP and Neurocardiac Injury Severity, Noninvasive Cardiac Output, and Outcomes After Aneurysmal Subarachnoid Hemorrhage.
    Biol Res Nurs 2017 Oct 19;19(5):531-537. Epub 2017 Jun 19.
    4 School of Nursing, University of Jordan, Amman, Jordan.
    Introduction: Neurocardiac injury, a type of myocardial dysfunction associated with neurological insult to the brain, occurs in 31-48% of aneurysmal subarachnoid hemorrhage (aSAH) patients. Cardiac troponin I (cTnI) is commonly used to diagnose neurocardiac injury. Brain natriuretic peptide (BNP), another cardiac marker, is more often used to evaluate degree of heart failure. Read More

    Measuring Stress in Young Children Using Hair Cortisol: The State of the Science.
    Biol Res Nurs 2017 Oct 15;19(5):499-510. Epub 2017 Jun 15.
    1 College of Nursing, The Ohio State University, Columbus, OH, USA.
    Extensive literature suggests that adverse experiences in early childhood may deleteriously impact later health. These effects are thought to be related to the impact of persistent or chronic stress on various biological processes, mediated by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and ultimately irregularities in cortisol levels. Ameliorating persistent stress in young children requires accurately measuring the chronicity of physiologic stress, which is difficult in young children because of unreliable self-report and the burden and inaccuracy associated with using invasive acute-stress biomeasures. Read More

    Primer in Genetics and Genomics, Article 4-Inheritance Patterns.
    Biol Res Nurs 2017 07 22;19(4):465-472. Epub 2017 May 22.
    1 College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA.
    Since the completion of the Human Genome Project, much has been uncovered about inheritance of various illnesses and disorders. There are two main types of inheritance: Mendelian and non-Mendelian. Mendelian inheritance includes autosomal dominant, autosomal recessive, X-linked, and Y-linked inheritance. Read More

    Conducting Biobehavioral Research in Patients With Advanced Cancer: Recruitment Challenges and Solutions.
    Biol Res Nurs 2017 Oct 16;19(5):481-490. Epub 2017 May 16.
    2 School of Nursing, University of Maryland, Baltimore, MD, USA.
    Despite significant advances in cancer treatment and symptom management interventions over the last decade, patients continue to struggle with cancer-related symptoms. Adequate baseline and longitudinal data are crucial for designing interventions to improve patient quality of life and reduce symptom burden; however, recruitment of patients with advanced cancer in longitudinal research is difficult. Our purpose is to describe challenges and solutions to recruitment of patients with advanced cancer in two biobehavioral research studies examining cancer-related symptoms. Read More

    A Randomized Controlled Trial of the Effects of Mindfulness-Based Stress Reduction (MBSR[BC]) on Levels of Inflammatory Biomarkers Among Recovering Breast Cancer Survivors.
    Biol Res Nurs 2017 07 1;19(4):456-464. Epub 2017 May 1.
    8 Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.
    Purpose: The purpose of this substudy of a large randomized controlled trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction (Breast Cancer) (MBSR[BC]) program compared to usual care (UC) in normalizing blood levels of pro-inflammatory cytokines among breast cancer survivors (BCS).

    Method: A total of 322 BCS were randomized to either a 6-week MBSR(BC) program or a UC. At baseline and 6 and 12 weeks, 10 ml of venous blood and demographic and clinical data were collected and/or updated. Read More

    The Effect of Epidural Analgesia Alone and in Association With Other Variables on the Risk of Cesarean Section.
    Biol Res Nurs 2017 07 23;19(4):393-398. Epub 2017 Apr 23.
    3 Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain.
    Introduction: Epidural analgesia (EA) is the most widespread pharmacologic method of labor pain relief. There remains disagreement, however, regarding its adverse effects. The objective of this study was to determine the effect of EA administration on the risk of cesarean delivery and its causes (e. Read More

    Comparison of Hemodynamic Responses in the Prefrontal Cortex According to Differences in Self-Efficacy.
    Biol Res Nurs 2017 07 23;19(4):450-455. Epub 2017 Apr 23.
    1 Department of Occupational Therapy, School of Health Science and Social Welfare, Kibi International University, Takahashi, Okayama, Japan.
    Although self-efficacy has been used extensively in the field of nursing (e.g., as an outcome measure of nursing interventions), its underlying nature is poorly understood. Read More

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