2,952,744 results match your criteria Biological Psychology [Journal]


Characteristics of interactions at protein segments without non-local intramolecular contacts in the Protein Data Bank.

PLoS One 2018 11;13(12):e0205052. Epub 2018 Dec 11.

School of Life Science and Technology, Tokyo Institute of Technology, Nagatsuda-cho, Midori-ku, Yokohama, Kanagawa, Japan.

The principle of three-dimensional protein structure formation is a long-standing conundrum in structural biology. A globular domain of a soluble protein is formed by a network of atomic contacts among amino acid residues, but regions without intramolecular non-local contacts are often observed in the protein structure, especially in loop, linker, and peripheral segments with secondary structures. Although these regions can play key roles for protein function as interfaces for intermolecular interactions, their nature remains unclear. Read More

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December 2018
3 Reads

Predictive Value of Age-Bilirubin-International Normalized Ratio-Creatinine Score in Short-Term Survival of Acute-on-Chronic Hepatitis B Liver Failure.

Cell Physiol Biochem 2018 11;51(5):2484-2495. Epub 2018 Dec 11.

Department of Hepatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, China.

Background/aims: The age-bilirubin-international normalized ratio-creatinine (ABIC) score, which is a predictive model commonly used for alcoholic hepatitis, has not yet been studied in acute-on-chronic hepatitis B liver failure (HBV-ACLF). We aimed to investigate the predictive value of the ABIC score in patients with HBV-ACLF.

Methods: This retrospective study involved 398 patients diagnosed with HBV-ACLF, who were divided into a training cohort of 305 patients and a validation cohort of 93 patients. Read More

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December 2018

Stromal Cell-Derived CCL20 Promotes Tumor Progression and Osteolysis in Giant Cell Tumor of Bone.

Cell Physiol Biochem 2018 11;51(5):2472-2483. Epub 2018 Dec 11.

Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background/aims: Giant cell tumor of bone (GCTB), one of the most common primary bone tumors, leads to extensive bone destruction. However, the mechanisms underlying GCTB progression remain elusive and prognostic factors and treatment targets are required. In the current study, we explored the function of the chemokine family member CCL20 in GCTB progression. Read More

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December 2018
1 Read

Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection.

Cell Physiol Biochem 2018 11;51(5):2377-2396. Epub 2018 Dec 11.

State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou,

The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. Read More

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December 2018

RNA-Seq Analyses of the Role of miR-21 in Acute Pancreatitis.

Cell Physiol Biochem 2018 7;51(5):2198-2211. Epub 2018 Dec 7.

Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou,

Background/aims: Our previous study demonstrated that a deficiency of microRNA 21 (miR-21) protects mice from acute pancreatitis, yet the underlying molecular networks associated with miR-21 in pancreatitis and pancreatitis-associated lung injury remain unexplored.

Methods: We used next generation sequencing to analyze gene expression profiles of pancreatic tissues from wild-type (WT) and miR-21 knockout (KO) mice treated with caerulein by using a 1-day treatment protocol. The Database for Annotation, Visualization, and Integrated Discovery gene annotation tool and Ingenuity Pathway Analysis were used to analyze the molecular pathways, while quantitative real-time PCR, western blotting, and immunohistochemistry were used to explore the molecular mechanisms. Read More

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December 2018
3 Reads

Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies.

Eur Surg Res 2018 Dec 11;59(5-6):361-370. Epub 2018 Dec 11.

Division of Colorectal Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan,

Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Read More

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December 2018

Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells.

Biofabrication 2018 Dec 11. Epub 2018 Dec 11.

Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing, CHINA.

Growth-hormone-secreting pituitary adenoma (GHSPA) is a benign tumour with a high incidence and large economic burden, which greatly affects quality of life. The aetiological factors are yet to be clarified for GHSPA. Conventional two-dimensional (2D) monolayer culture of tumour cells cannot ideally reflect the growth status of tumours in the physiological environment, and insufficiencies of in vitro models have severely restricted the progress of cancer research. Read More

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December 2018

3D bioprinting of heterogeneous bi- and tri-layered hollow channels within gel scaffolds using scalable multi-axial microfluidic extrusion nozzle.

Biofabrication 2018 Dec 11. Epub 2018 Dec 11.

Department of Mechanical Engineering, McMaster University, Center for Advanced Micro-Electro-Fluidics, 1280 Main Street West, Hamilton, Ontario, CANADA L8S 4L7, Hamilton, CANADA.

One of the primary focuses in recent years in tissue engineering has been the fabrication and integration of vascular structures into artificial tissue constructs. However, most available methodologies lack the ability to create multi-layered concentric conduits inside natural extracellular matrices (ECMs) and gels that replicate more accurately the hierarchical architecture of biological blood vessels. In this work, we present a new microfluidic nozzle design capable of multi-axial extrusion in order to 3D print and pattern bi- and tri-layered hollow channel structures. Read More

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December 2018

Microfluidics for real-time direct monitoring of self- and co-assembly biomolecular processes.

Nanotechnology 2018 Dec 11. Epub 2018 Dec 11.

Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, ISRAEL.

Molecular self-assembly is a major approach for the fabrication of functional supramolecular nanomaterials. This dynamic, straightforward, bottom-up procedure may result in the formation of various architectures at the nano-scale, with remarkable physical and chemical characteristics. Biological and bio-inspired building blocks are especially attractive due to their intrinsic tendency to assemble into layered well-organized structures, as well as their inherent biocompatibility. Read More

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December 2018

Cumulus-oocyte interactions and programmed cell death in bovine embryos produced in vitro.

Theriogenology 2018 Nov 26;126:81-87. Epub 2018 Nov 26.

Laboratory of Molecular Biology, Faculty of Animal Science, University of Sao Paulo, São Paulo, Brazil.

This study investigated the interactions between cumulus cells (CCs) and oocytes and programmed cell death in bovine cumulus-oocyte complexes (COCs) with different morphological characteristics. DNA fragmentation was assessed in CCs at 0 and 24 h of maturation, as well as parthenogenetic developmental competence on the 9th day post-activation, blastocyst quality and BCL-2 and BAX transcript levels in matured CCs. Most immature oocytes in the COC-A group (full cumulus and several compact layers) were in the initial germinal vesicle (iGV) stage, exhibiting minimal or no DNA damage. Read More

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November 2018

A systematic assessment of statistics, risk factors, and underlying features involved in pancreatic cancer.

Cancer Epidemiol 2018 Dec 8;58:104-110. Epub 2018 Dec 8.

Department of Bioinformatics & Applied Sciences, Indian Institute of Information Technology, Allahabad, 211015, India. Electronic address:

Pancreatic cancer remains the fourth leading cause of cancer-related death in the world, and will continue to become the number two cause of cancer-related death unless a remarkable breakthrough is achieved. With a slim chance of early diagnosis, surgery can only provide a median survival of 17-23 months. The presence of a dense stroma makes this cancer resilient to chemotherapy, with very few potent inhibitors like nab paclitaxelin available that can work in combination with chemotherapeutic agents. Read More

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December 2018
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Daily oxytocin patterns in relation to psychopathy and childhood trauma in residential youth.

Psychoneuroendocrinology 2018 Dec 1;102:105-113. Epub 2018 Dec 1.

Behavioural Science Institute, Radboud University, Nijmegen, the Netherlands; Stichting Conrisq Groep, the Netherlands; Stichting Jeugdzorg Sint Joseph, the Netherlands; Maastricht University, the Netherlands.

Inconsistent findings have been found on the relation between oxytocin levels and psychopathy or callous-unemotional (CU) traits in humans, potentially because the role of trauma in oxytocin secretion and the distinction between primary and secondary psychopathy have been overlooked so far. Primary psychopathy has a stronger biological background, whereas secondary psychopathy mainly develops due to environmental adversity, such as childhood trauma. This study investigated the interaction effects of CU traits and childhood trauma on daily salivary oxytocin levels in 57 males living in residential youth care facilities. Read More

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December 2018

Why we can't determine reliably the age of a subject on the basis of his maturation degree.

J Forensic Leg Med 2018 Dec 5;61:97-101. Epub 2018 Dec 5.

Past Director of the Complex Unit of Auxology, Faculty of Medicine and Surgery, Università degli Studi di Torino, Turin, Italy. Electronic address:

Background: Maturation is the irreversible biological process leading to adult form or function. The degree of maturation can be derived from the examination of maturity indicators, i.e. Read More

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December 2018
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3‑Bromo‑5‑(ethoxymethyl)‑1,2‑benzenediol inhibits LPS-induced pro-inflammatory responses by preventing ROS production and downregulating NF-κB in vitro and in a zebrafish model.

Int Immunopharmacol 2018 Dec 8;67:98-105. Epub 2018 Dec 8.

Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Republic of Korea. Electronic address:

The anti-inflammatory effects of 3‑bromo‑5‑(ethoxymethyl)‑1,2‑benzenediol (BEMB) from Polysiphonia morrowii were evaluated in lipopolysaccharide (LPS)-induced RAW264.7 cells and zebrafish embryo. BEMB showed anti-inflammatory effects by inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS), and the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in the LPS-activated RAW264. Read More

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December 2018

Synthesizing, characterizing, and toxicity evaluating of Phycocyanin-ZnO nanorod composites: A back to nature approaches.

Colloids Surf B Biointerfaces 2018 Dec 4;175:221-230. Epub 2018 Dec 4.

Division of Industrial & Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), P.O. Box 14155-6343, Tehran, Iran. Electronic address:

C-Phycocyanin pigment was purified from a native cyanobacterial strain using a novel consecutive multi-step procedure and utilized for the first time for the green synthesis of phycocyanin-zinc oxide nanorods (PHY-ZnO NRs) by a simple, low-cost and eco-friendly approach. The PHY-ZnO NRs were characterized using UV-vis spectroscopy, X-ray diffraction (XRD), zeta potential measurement, FTIR, SEM, TEM, differential scanning calorimetry (DSC), thermogravimetric (TGA), and EDX spectroscopy analysis. The UV-vis spectra showed an absorption band at 364 nm which is characteristic of ZnO nanoparticles (ZnONPs). Read More

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December 2018

The presence of the low molecular mass carbonic anhydrase in photosystem II of C3 higher plants.

J Plant Physiol 2018 Nov 20;232:94-99. Epub 2018 Nov 20.

Institute of Basic Biological Problems of Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.

The carrier of carbonic anhydrase (CA) activity was detected in gel among low molecular mass proteins from pea, spinach and Arabidopsis, after nondenaturing electrophoresis in PAAG of the dodecyl-β-d-maltoside treated PSII membranes (the fragments of thylakoid membrane containing PSII complexes). The elimination of Mn-stabilizing protein PsbO by treatment of PSII membranes with salts, did not lead to a decrease in CA activity observed in the gel although it reduced the amount of this protein down to 25% compared to the original sample. The isolated protein PsbO did not demonstrated CA activity. Read More

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November 2018

Root colonization by Pseudomonas chlororaphis primes tomato (Lycopersicum esculentum) plants for enhanced tolerance to water stress.

J Plant Physiol 2018 Nov 16;232:82-93. Epub 2018 Nov 16.

National Research Council of Italy - Institute for Sustainable Plant Protection (CNR-IPSP), Viale P.A. Mattioli 25, 10125 Torino, Italy.

Previous research demonstrated that Pseudomonas chlororaphis subsp. aureofaciens strain M71, a plant growth promoting bacterium (PGPB), exerts beneficial effects on plant metabolism and primes tolerance mechanisms against biotic stresses in tomatoes. We designed an experiment to assess whether root colonization with P. Read More

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November 2018

Exogenous alpha lipoic acid can stimulate photosystem II activity and the gene expressions of carbon fixation and chlorophyll metabolism enzymes in maize seedlings under drought.

J Plant Physiol 2018 Nov 29;232:65-73. Epub 2018 Nov 29.

Department of Biology, Faculty of Science, Karadeniz Technical University, 61080, Trabzon, Turkey. Electronic address:

Protective compounds such as non-enzymatic antioxidants, osmolytes and signal molecules have been applied to plants exposed to various environmental stresses to increase their stress tolerance. However, there are not enough records about the response of plants to alpha lipoic acid (ALA) application with antioxidant properties. Therefore, this study was designed to evaluate the function of exogenous ALA on the photosynthetic performance of maize seedlings grown in hydroponic conditions under drought stress. Read More

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November 2018

Changes in proteolytic activity and protein carbonylation in shoots of Alyssum montanum ecotypes under multi-metal stress.

J Plant Physiol 2018 Nov 19;232:61-64. Epub 2018 Nov 19.

Unit of Botany and Plant Physiology, Institute of Plant Biology and Biotechnology, University of Agriculture in Krakow, Al. 29 Listopada 54, 31-425, Krakow, Poland.

The aim of present study was to evaluate the proteolytic response of metallicolous (M) and nonmetallicolous (NM) ecotypes of Alyssum montanum under heavy metals (HMs) stress. Therefore, shoot cultures of tested species grown on medium enriched simultaneously with 0.7 mM ZnSO, 3. Read More

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November 2018

Expression profiles of organogenesis-related genes over the time course of one-step de novo shoot organogenesis from intact seedlings of kohlrabi.

J Plant Physiol 2018 Nov 8;232:257-269. Epub 2018 Nov 8.

Institute for Biological Research "Siniša Stanković", University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.

Kohlrabi (Brassica oleracea var. gongylodes) is an important vegetable crop that is able to undergo shoot regeneration in culture from intact seedlings in a single-step regeneration process, using cytokinin as the only plant growth regulator. In this work, we present the expression profiles of seven organogenesis-related genes over the time course of shoot regeneration from intact seedlings of kohlrabi cv. Read More

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November 2018

Apple SUMO E3 ligase MdSIZ1 is involved in the response to phosphate deficiency.

J Plant Physiol 2018 Nov 22;232:216-225. Epub 2018 Nov 22.

MOA Key Laboratory of Horticultural Crop Biology and Germplasm Innovation, Shandong Agricultural University, Tai-An, Shandong, China; College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An, Shandong, China; State Key Laboratory of Crop Biology, Shandong Agricultural University, Tai-An, Shandong, China. Electronic address:

In plants, SIZ1 regulates abiotic and biotic stress responses by promoting the SUMOylation of proteins. The apple MdSIZ1 protein has conserved domains similar to those of Arabidopsis AtSIZ1. Real-time fluorescent quantitative analysis showed that MdSIZ1 gene expression was induced by phosphate-deficient conditions. Read More

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November 2018

A roadmap towards a functional paradigm for learning & memory in plants.

J Plant Physiol 2018 Nov 8;232:209-215. Epub 2018 Nov 8.

Institute of Applied Biosciences, Center for Research & Technology (CERTH), Thessaloniki, Greece.

In plants, the acquisition, processing and storage of empirical information can result in the modification of their behavior according to the nature of the stimulus, and yet this area of research remained relatively understudied until recently. As the body of evidence supporting the inclusion of plants among the higher organisms demonstrating the adaptations to accomplish these tasks keeps increasing, the resistance by traditional botanists and agricultural scientists, who were at first cautious in allowing the application of animal models onto plant physiology and development, subsides. However, the debate retains much of its heat, a good part of it originating from the controversial use of nervous system terms to describe plant processes. Read More

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November 2018

Cre-miR914-regulated RPL18 is involved with UV-B adaptation in Chlamydomonas reinhardtii.

J Plant Physiol 2018 Nov 22;232:151-159. Epub 2018 Nov 22.

Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. Electronic address:

UV radiation is a serious threat to life, and algae have developed highly efficient adaptations to UV radiation through the course of evolution. To date, studies investigating the mechanisms of UV adaptation in algae have focused on physiological regulation and associated protein coding genes, with only a few reports on associated protein non-coding genes. In a previous study, we found that Cre-miR914 was significantly down-regulated in Chlamydomonas reinhardtii in response to heat shock. Read More

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November 2018

Comparison of changes in water status and photosynthetic parameters in wild type and abscisic acid-deficient sitiens mutant of tomato (Solanum lycopersicum cv. Rheinlands Ruhm) exposed to sublethal and lethal salt stress.

J Plant Physiol 2018 Dec 8;232:130-140. Epub 2018 Dec 8.

Department of Plant Biology, University of Szeged, Közép fasor 52, H-6726, Szeged, Hungary.

Abscisic acid (ABA) regulates many salt stress-related processes of plants such as water balance, osmotic stress tolerance and photosynthesis. In this study we investigated the responses of wild type (WT) and the ABA-deficient sitiens mutant of tomato (Solanum lycopersicum cv. Rheinlands Ruhm) to sublethal and lethal salt stress elicited by 100 mM and 250 mM NaCl, respectively. Read More

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December 2018

RNAi-mediated silencing of pinoresinol lariciresinol reductase in Linum album hairy roots alters the phenolic accumulation in response to fungal elicitor.

J Plant Physiol 2018 Nov 10;232:115-126. Epub 2018 Nov 10.

Department of Plant Pathology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.

Lignans are diphenolic compounds produced in plants via coupling of two coniferyl alcohol molecules with the aid of a dirigent protein to form pinoresinol (PINO). The latter is reduced via lariciresinol (LARI) to secoisolariciresinol by the bifunctional pinoresinol-lariciresinol reductase (PLR). In this study, we clarified the consequences of altered lignan biosynthesis on amino acids, phenolics compounds and lignin in the hairy roots of Linum album with an ihpRNAi construct to silence PLR gene expression. Read More

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November 2018

Enantioselective LC-MS/MS for anthropogenic markers of septic tank discharge.

Chemosphere 2018 Dec 3;219:191-201. Epub 2018 Dec 3.

School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, AB10 7GJ, UK. Electronic address:

Households in rural locations utilize septic tanks for wastewater treatment and can cause surface water contamination. A new methodology was developed to help investigate the role septic tanks play in the dissemination of prescription and over-the-counter drugs, personal care products and stimulants in the aqueous environment. Simultaneous analysis of 16 chiral and achiral anthropogenic markers was achieved using a Chirobiotic V2 enantioselective column in polar ionic mode. Read More

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December 2018

Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae.

Chemosphere 2018 Dec 5;219:155-164. Epub 2018 Dec 5.

State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China. Electronic address:

Deltamethrin is widely used because of its low toxicity and high efficiency. Although its potential toxicity has been reported, its effects on cardiovascular system and motor behavior and its underlying mechanisms have remained unclear. In this study, the effects of deltamethrin on the development, cardiovascular system and motor behavior of zebrafish larvae and their possible mechanisms were evaluated using the transgenic zebrafish Tg (kdrl:mCherry) and Tg(myl7:GFP). Read More

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December 2018

Impact of maternal low-level cadmium exposure on glucose and lipid metabolism of the litter at different ages after weaning.

Chemosphere 2018 Nov 26;219:109-121. Epub 2018 Nov 26.

Univ. Grenoble Alpes, Inserm U1055, LBFA, 38000 Grenoble, France. Electronic address:

Cadmium (Cd) is a metal which may participate in the development of type II diabetes even if Cd exposure levels are mild. However, experimental studies focusing on daily environmentally relevant doses are scarce, particularly for glucose metabolism of the offspring of chronically exposed mothers. The aim is to measure the impact of maternal low level Cd exposure on glucose and lipid metabolism of offspring. Read More

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November 2018

Mesophyll conductance limitation of photosynthesis in poplar under elevated ozone.

Sci Total Environ 2018 Dec 4;657:136-145. Epub 2018 Dec 4.

Department of Biological and Environmental Sciences, University of Gothenburg, SE-405 30 Gothenburg, Sweden.

Finite mesophyll conductance (g) reduces the rate of CO diffusion from the leaf intercellular space to the chloroplast and constitutes a major limitation of photosynthesis in trees. While it is well established that g is decreased by stressors such as drought and high temperature, few studies have investigated if the phytotoxic air pollutant ozone (O) affects g. We quantified the relative importance of three different types of limitations of photosynthesis in poplar trees exposed to elevated O: decreases in stomatal conductance, g and biochemical photosynthetic capacity. Read More

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December 2018
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Do concentrations of perfluoroalkylated acids (PFAAs) in isopods reflect concentrations in soil and songbirds? A study using a distance gradient from a fluorochemical plant.

Sci Total Environ 2018 Dec 7;657:111-123. Epub 2018 Dec 7.

Systemic Physiological and Ecotoxicologal Research (SPHERE), Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium. Electronic address:

Perfluoroalkylated acids (PFAAs) are persistent chemicals that have been detected globally in the environment and in wildlife. Although it is known that PFAAs sorb to solid matrices, little is known on PFAA concentrations in soils. PFAA pollution has often been studied in aquatic invertebrates. Read More

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December 2018

Micro(nano)plastics: An un-ignorable carbon source?

Sci Total Environ 2018 Dec 5;657:108-110. Epub 2018 Dec 5.

College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China.

Micro(nano)plastics, new emerging contaminants, are widely found in the environment due to continuous release. Massive and widespread presence of micro(nano)plastics may have a significant impact on the calculation of total organic carbon, and potentially result in misunderstanding of the overall environmental pollution level. Previous studies typically paid attention to the environmental distribution, source, analysis methods and technologies, as well as the environmental and ecological effects of micro(nano)plastics. Read More

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December 2018

In vivo transcriptome changes of human white blood cells in response to vitamin D.

J Steroid Biochem Mol Biol 2018 Dec 8. Epub 2018 Dec 8.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

In the vitamin D intervention study VitDbol (NCT02063334) blood samples were drawn directly before an oral bolus (2000 µg vitamin D) and 24 h later. The focus of phase II of VitDbol was the transcriptome-wide analysis of the effects of vitamin D gene expression in human peripheral blood mononuclear cells (PBMCs). All five participants responded in an individual fashion to the bolus by increases in serum levels of the vitamin D metabolites 25-hydroxyvitamin D (25(OH)D) and 1α,25-dihydroxyvitamin D (1,25(OH)D). Read More

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December 2018
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Joint contractures and acquired deforming hypertonia in older people: Which determinants?

Ann Phys Rehabil Med 2018 Dec 8. Epub 2018 Dec 8.

Department of Medicine, Division of Physical Medicine and Rehabilitation, University of Ottawa, Bone and Joint Research Laboratory, The Ottawa Hospital Research Institute, ON, Canada.

Joint contractures and acquired deforming hypertonia are frequent in dependent older people. The consequences of these conditions can be significant for activities of daily living as well as comfort and quality of life. They can also negatively affect the burden of care and care costs. Read More

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December 2018
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Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival.

Peptides 2018 Dec 8. Epub 2018 Dec 8.

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Road, CB 7545, Chapel Hill, NC, 27599, USA. Electronic address:

Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are small peptides derived from a common precursor, pre-proadrenomedullin. Although AM and PAMP share hypotensive effects in the cardiovascular system, the peptides also exert diverse and distinct effects on endocrine physiology, innate immunity, cytoskeletal biology and receptor signaling pathways. Tremendous knowledge has been gleaned from the study of several genetic animal models of AM deletion or overexpression, some of which also simultaneously delete the coding region for PAMP peptide. Read More

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December 2018

Sex differences in the temporal neuromolecular and synaptogenic effects of the rapid-acting antidepressant drug ketamine in the mouse brain.

Neuroscience 2018 Dec 8. Epub 2018 Dec 8.

Department of Biology & Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, Ohio, USA. Electronic address:

Preclinical evidence suggests that ketamine's rapid and sustained antidepressant actions are due to the induction of synaptogenesis in the medial prefrontal cortex (mPFC) and the hippocampus (HIPP), two brain regions implicated in the pathophysiology of major depression. However, research on the neurobiological effects of ketamine has focused almost exclusively on males. Findings from our group and others indicate that female rodents are more reactive to ketamine's antidepressant effects, since they respond to lower doses in antidepressant-predictive behavioral models. Read More

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December 2018

Diabetes-induced neuropathic mechanical hyperalgesia depends on P2X4 receptor activation in Dorsal Root Ganglia.

Neuroscience 2018 Dec 8. Epub 2018 Dec 8.

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address:

Peripheral diabetic neuropathy (PDN) manifests in 50-60% of type I and II diabetic patients and is the major cause of limb amputation. Adequate therapy for PDN is a current challenge. There are evidences that the activation of the P2X4 receptor (P2X4R) expressed on microglial cells of the central nervous system takes part in the development of neuropathic pain. Read More

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December 2018
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Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Cancer Cell 2018 Dec;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Read More

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December 2018

Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.

Cancer Cell 2018 Dec;34(6):922-938.e7

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

Drug resistance represents a major challenge to achieving durable responses to cancer therapeutics. Resistance mechanisms to epigenetically targeted drugs remain largely unexplored. We used bromodomain and extra-terminal domain (BET) inhibition in neuroblastoma as a prototype to model resistance to chromatin modulatory therapeutics. Read More

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December 2018

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines.

Cancer Cell 2018 Dec;34(6):879-891

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

Defects in apoptotic cell death can promote cancer and impair responses of malignant cells to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by keeping the cell death effectors, BAX and BAK, in check. The BH3-only proteins initiate apoptosis by neutralizing the pro-survival BCL-2 proteins. Read More

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December 2018

Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: BIM Finally.

Cancer Cell 2018 Dec;34(6):869-871

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA. Electronic address:

Glucocorticoid resistance represents a major challenge in treating acute lymphoblastic leukemia. In this issue of Cancer Cell, Jing and colleagues show epigenetic deregulation of glucocorticoid-induced BIM activation in glucocorticoid-resistant leukemia cells, and restore glucocorticoid-receptor-induced BIM upregulation with DNA demethylating agents to effectively enhance glucocorticoid response. Read More

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December 2018

Suppressive effect of ascophyllan HS on postprandial blood sugar level through the inhibition of α-glucosidase and stimulation of glucagon-like peptide-1 (GLP-1) secretion.

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Nagasaki 852-8521, Japan. Electronic address:

A sulfated polysaccharide ascophyllan inhibited α-glucosidase in a concentration dependent manner, and >90% activity was inhibited at 1.0 mg/mL. The inhibitory activity was much higher than that of acarbose. Read More

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December 2018

Biopolymers - Calcium phosphates composites with inclusions of magnetic nanoparticles for bone tissue engineering.

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Grigore T. Popa University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Department of Biomedical Sciences, Iasi, Romania. Electronic address:

Composites based on combination of biopolymers (chitosan, hyaluronic acid and bovine serum albumin or gelatin), calcium phosphates (CP) and magnetic nanoparticles have been prepared by a biomimetic co-precipitation method. The biomimetic strategy is inspired by natural mineralization processes, where the synthesized minerals are usually combined with proteins, polysaccharides or other mineral forms to form composite, in physiological conditions of temperature and pH. The morphology of the magnetic composites, studied using scanning electron microscopy (SEM) indicated a macroporous structure, which influenced the retention of simulated biological fluids. Read More

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December 2018

Devil's hand conceals behind the obscure side of AgNPs: A letter to the editor.

Authors:
Hassan Rasouli

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Medical Biology Research Center (MBRC), Kermanshah University of Medical Science, Kermanshah, Iran. Electronic address:

From that time AgNPs become one of the most accessible and important antibacterial agents in our world, thousands of papers published regarding investigating all aspects of these materials. When the time elapsed and novel methods contrived to follow the fingerprint of AgNPs in the in vivo models, some critical concerns and arguments also appeared between researchers about the safety of these compounds for living cells. The paper by Dehvari and Ghahaghaei published in Volume 108 International Journal of Biological Macromolecules, pages 1128-1139 (Dehvari and Ghahghaei, 2018) suffered from some errors from safety concerns to obscurities in the results and the application of paper for applicable uses in medicine or elsewhere. Read More

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December 2018
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Clinicopathologic and prognostic significance of MKK4 and MKK7 in resectable pancreatic ductal adenocarcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China. Electronic address:

Mitogen-activated protein kinase kinase 4 (MKK4) and mitogen-activated protein kinase kinase 7 (MKK7) were shown to regulate biological behavior in many malignancies. In pancreatic ductal adenocarcinoma (PDAC), it remains controversial whether MKK4 and MKK7 have pro-oncogenic or tumor-suppressive activities. Furthermore, their clinicopathologic and prognostic implications are unknown. Read More

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December 2018

Strain State Dependent Anisotropic Viscoelasticity of Tendon-to-Bone Insertion.

Math Biosci 2018 Dec 8. Epub 2018 Dec 8.

Mechanical and Aerospace Engineering Department, North Carolina State University, R3158 Engineering Building 3, Campus Box 7910, 911 Oval Drive, Raleigh, NC 27695. Electronic address:

Tendon-to-bone insertion tissues may be considered as functionally-graded connective tissues, providing a gradual transition from soft tendon to hard bone tissue, and functioning to alleviate stress concentrations at the junction of these tissues. The tendon-to-bone insertion tissues demonstrate pronounced viscoelastic behavior, like many other biological tissues, and are designed by the nature to alleviate stress at physiological load rates and strains states. In this paper we present experimental data showing that under biaxial tension tendon-to-bone insertion demonstrates rate-dependent behavior and that stress-strain curves for the in-plane components of stress and strain become less steep when strain rate is increased, contrary to a typical viscoelastic behavior, where the opposite trend is observed. Read More

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December 2018

Micro-quantity straw as a carrier for cryopreservation of oligozoospermic semen samples: Effects of storage times and cryoprotectant.

Cryobiology 2018 Dec 8. Epub 2018 Dec 8.

Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address:

Application of an appropriate freezing carrier is crucial for improving post-thaw recovery of oligozoospermic samples. In this study, our purpose is developing a user-friendly, easy handling and close micro-quantity (MQ) straw along with different freezing media, for cryopreservation of oligozoospermic samples. Twenty oligozoospermic semen samples were collected and mixed with glycerol egg yolk citrate (GEYC) or Spermfreeze (SPF) medium. Read More

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December 2018

The Antifibrotic Activity of Prostacyclin Receptor Agonism is Mediated through Inhibition of YAP/TAZ.

Am J Respir Cell Mol Biol 2018 Dec 11. Epub 2018 Dec 11.

Idorsia Pharmaceuticals Ltd, 510456, Cardiovascuklar and Fibrosis Biology, Allschwil, Switzerland ;

Idiopathic pulmonary fibrosis (IPF) is a life-threatening progressive disease characterized by loss of alveolar epithelial cells, inflammation and aberrant fibroblast activation. The two currently approved therapies do not halt or reverse tissue remodeling and therefore novel disease modifying mechanisms are needed. Our results describe YAP/TAZ inhibition through IP receptor activation as a novel mechanism that suppresses pro-fibrotic (myo)fibroblast activity. Read More

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December 2018

A Comprehensive Analysis of Protocols for Deriving Dopaminergic Neurons from Human Pluripotent Stem Cells.

Stem Cells Transl Med 2018 Dec 10. Epub 2018 Dec 10.

Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, California, USA.

The potential applications of human embryonic and induced pluripotent stem cells has led to immense interest in developing new protocols to differentiate specific cell types or modifying existing protocols. To investigate to what extent and why new protocols for the same cell types are developed and adopted, we systematically evaluated 158 publications (2004-2017) that differentiated human stem cells into dopaminergic neurons. We categorized each article by degree of novelty and recorded motivations for protocol development. Read More

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December 2018

Autoimmune hemolytic anemia and immune thrombocytopenia following hematopoietic stem cell transplant: A critical review of the literature.

Pediatr Blood Cancer 2018 Dec 10:e27569. Epub 2018 Dec 10.

Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, Texas.

Autoimmune cytopenias (AIC) post-hematopoietic stem cell transplant (HSCT) are rare but exceptionally challenging complication. We conducted a comprehensive literature review and identified a pooled incidence of post-HSCT autoimmune hemolytic anemia and/or immune thrombocytopenia of 2.66% (SE = 0. Read More

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December 2018

The pK values of the catalytic residues in the retaining glycoside hydrolase T26H mutant of T4 lysozyme.

Protein Sci 2018 Dec 7. Epub 2018 Dec 7.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada, V6T 1Z3.

T4 phage lysozyme (T4L) is an enzyme that cleaves bacterial cell wall peptidoglycan. Remarkably, the single substitution of the active site Thr26 to a His (T26H) converts T4L from an inverting to a retaining glycoside hydrolase with transglycosylase activity. It has been proposed that T26H-T4L follows a double displacement mechanism with His26 serving as a nucleophile to form a covalent glycosyl-enzyme intermediate (Kuroki et al. Read More

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December 2018
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