3,267,327 results match your criteria Biological & pharmaceutical bulletin[Journal]


New insights in the management of Hepatocellular Adenoma.

Liver Int 2020 May 28. Epub 2020 May 28.

Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Hepatocellular adenoma (HCA) are benign liver tumors that may be complicated by hemorrhage or malignant transformation to hepatocellular carcinoma. Epidemiological data are fairly outdated, but it is likely to assume that the incidence has increased over the past decades as HCA are more often incidentally found due to the more widespread use of imaging techniques and the increased incidence of obesity. Various molecular subgroups have been described. Read More

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http://dx.doi.org/10.1111/liv.14547DOI Listing

Biogenic nanoparticles as immunomodulator for tumor treatment.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2020 May 28:e1646. Epub 2020 May 28.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), Beijing, China.

In the past few decades, cancer immunotherapy has developed rapidly. Cancer immunotherapy, either used alone or in combination with a variety of immunotherapies (such as cancer therapeutic vaccines, adoptive cell therapy, or immune checkpoint blocking therapy), is a very attractive class of cancer therapy. However, so far, the clinical effect of most cancer immunotherapy is not satisfactory. Read More

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http://dx.doi.org/10.1002/wnan.1646DOI Listing

Neuropathological and biochemical investigation of Hereditary Ferritinopathycases with ferritin light chain mutation: Prominent protein aggregation in the absence of major mitochondrial or oxidative stress.

Neuropathol Appl Neurobiol 2020 May 28. Epub 2020 May 28.

Wolfson Building, Newcastle University, Claremont Place, Newcastle upon Tyne, NE2 4AA, UK.

Aims: Neuroferritinopathyor Hereditary Ferritinopathy (HF)is an autosomal dominant movement disorder due to mutation in the light chain of the iron storage protein ferritin (FTL).HF is the only late-onset neurodegeneration with brain iron accumulation disorder andstudy of HF offers a unique opportunity to understand the role of iron in more common neurodegenerative syndromes.

Methods: We carried out pathological and biochemical studies of six individuals with the same pathogenic FTL mutation. Read More

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http://dx.doi.org/10.1111/nan.12634DOI Listing

Maternal obesity reduces placental autophagy marker expression in uncomplicated pregnancies.

J Obstet Gynaecol Res 2020 May 28. Epub 2020 May 28.

Department of Obstetrics and Gynaecology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.

Aim: Obesity has been associated with changes in autophagy and its increasing prevalence among pregnant women is implicated in higher rates of placental-mediated complications of pregnancy such as pre-eclampsia and intrauterine growth restriction. Autophagy is involved in normal placentation, thus changes in autophagy may lead to impaired placental function and development. The aim of this study was to investigate the connection between obesity and autophagy in the placenta in otherwise uncomplicated pregnancies. Read More

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http://dx.doi.org/10.1111/jog.14315DOI Listing

Identification of GABAergic neurons innervating the zebrafish lateral habenula.

Eur J Neurosci 2020 May 28. Epub 2020 May 28.

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.

Habenula neurons are constantly active. The level of activity affects mood and behaviour, with increased activity in the lateral habenula reflecting exposure to punishment and a switch to passive coping and depression. Here, we identify GABAergic neurons that could reduce activity in the lateral habenula of larval zebrafish. Read More

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http://dx.doi.org/10.1111/ejn.14843DOI Listing

The C-terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity, and disease.

Eur J Neurosci 2020 May 28. Epub 2020 May 28.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

NMDA receptors are part of the ionotropic glutamate receptor family, and are crucial for neurotransmission and memory. At the cellular level, the effects of activating these receptors includes long-term potentiation (LTP) or depression (LTD). The NMDA receptor is a stringently gated cation channel permeable to Ca , and it shares the molecular architecture of a tetrameric ligand-gated ion channel with the other family members. Read More

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http://dx.doi.org/10.1111/ejn.14842DOI Listing

A rice chloroplast-localized ABC transporter ARG1 modulates cobalt and nickel homeostasis and contributes to photosynthetic capacity.

New Phytol 2020 May 28. Epub 2020 May 28.

Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.

• Transport and homeostasis of transition metals in chloroplasts, which are accurately regulated to ensure supply and to prevent toxicity induced by these metals, is thus crucial for chloroplasts function and photosynthetic performance. However, the mechanisms that maintain the balance of transition metals in chloroplasts remain largely unknown. • We have characterized an albino-revertible green 1 (arg1) rice mutant. Read More

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http://dx.doi.org/10.1111/nph.16708DOI Listing

Chloroplast mRNAs are 3' polyuridylylated in the green alga Pithophora roettleri (Cladophorales).

J Phycol 2020 May 28. Epub 2020 May 28.

Department of Natural Sciences, The University of Virginia's College at Wise, 1 College Ave, Wise, VA, 24293, USA.

Species within the green algal order, Cladophorales, have an unconventional plastome structure where individual coding regions or small numbers of genes occur as linear single-stranded DNAs folded into hairpin structures. Another group of photosynthetic organisms with an equivalently reduced chloroplast genome are the peridinin dinoflagellates of the Alveolata eukaryotic lineage whose plastomes are mini-circles carrying one or a few genes required for photosynthesis. One unusual aspect of the Alveolata is the polyuridylylation of mRNA 3' ends among non-peridinin dinoflagellates, and the chromerid algae. Read More

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http://dx.doi.org/10.1111/jpy.13033DOI Listing

Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model.

J Antimicrob Chemother 2020 May 28. Epub 2020 May 28.

Laboratory for Antimicrobial Pharmacodynamics, University at Buffalo, Buffalo, NY, USA.

Background: MBL-producing strains of Enterobacteriaceae are a major public health concern. We sought to define optimal combination regimens of ceftazidime/avibactam with aztreonam in a hollow-fibre infection model (HFIM) of MBL-producing strains of Escherichia coli and Klebsiella pneumoniae.

Methods: E. Read More

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http://dx.doi.org/10.1093/jac/dkaa197DOI Listing

Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.

Brain 2020 May 28. Epub 2020 May 28.

Departments of Physiology and Cell Biology, Brain and Cognitive Sciences, The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Repetitive mild traumatic brain injury in American football players has garnered increasing public attention following reports of chronic traumatic encephalopathy, a progressive tauopathy. While the mechanisms underlying repetitive mild traumatic brain injury-induced neurodegeneration are unknown and antemortem diagnostic tests are not available, neuropathology studies suggest a pathogenic role for microvascular injury, specifically blood-brain barrier dysfunction. Thus, our main objective was to demonstrate the effectiveness of a modified dynamic contrast-enhanced MRI approach we have developed to detect impairments in brain microvascular function. Read More

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http://dx.doi.org/10.1093/brain/awaa140DOI Listing

Studying human reproductive biology through single-cell analysis and in vitro differentiation of stem cells into germ cell-like cells.

Hum Reprod Update 2020 May 28. Epub 2020 May 28.

Department of Basic Medical Sciences, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China.

Background: Understanding the molecular and cellular mechanisms of human reproductive development has been limited by the scarcity of human samples and ethical constraints. Recently, in vitro differentiation of human pluripotent stem cells into germ cells and single-cell analyses have opened new avenues to directly study human germ cells and identify unique mechanisms in human reproductive development.

Objective And Rationale: The goal of this review is to collate novel findings and insightful discoveries with these new methodologies, aiming at introducing researchers and clinicians to the use of these tools to study human reproductive biology and develop treatments for infertility. Read More

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http://dx.doi.org/10.1093/humupd/dmaa021DOI Listing

Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1.

J Antimicrob Chemother 2020 May 28. Epub 2020 May 28.

The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway.

Background: MBLs form a large and heterogeneous group of bacterial enzymes conferring resistance to β-lactam antibiotics, including carbapenems. A large environmental reservoir of MBLs has been identified, which can act as a source for transfer into human pathogens. Therefore, structural investigation of environmental and clinically rare MBLs can give new insights into structure-activity relationships to explore the role of catalytic and second shell residues, which are under selective pressure. Read More

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http://dx.doi.org/10.1093/jac/dkaa175DOI Listing

The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin-angiotensin system.

Eur Heart J Cardiovasc Pharmacother 2020 May 28. Epub 2020 May 28.

Vascular Medicine, Amsterdam UMC, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.

The SARS-CoV-2 pandemic is a healthcare crisis caused by insufficient knowledge applicable to effectively combat the virus. Therefore, different scientific discovery strategies need to be connected, to generate a rational treatment which can be made available as rapidly as possible. This relies on a solid theoretical understanding of the mechanisms of SARS-CoV-2 infection and host responses, which is coupled to the practical experience of clinicians that are treating patients. Read More

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http://dx.doi.org/10.1093/ehjcvp/pvaa053DOI Listing

Cortical astrocytes regulate ethanol consumption and intoxication in mice.

Neuropsychopharmacology 2020 May 28. Epub 2020 May 28.

Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, 78712-01095, USA.

Astrocytes are fundamental building blocks of the central nervous system. Their dysfunction has been implicated in many psychiatric disorders, including alcohol use disorder, yet our understanding of their functional role in ethanol intoxication and consumption is very limited. Astrocytes regulate behavior through multiple intracellular signaling pathways, including G-protein coupled-receptor (GPCR)-mediated calcium signals. Read More

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http://dx.doi.org/10.1038/s41386-020-0721-0DOI Listing

Microfibril-Associated Protein 2 (MFAP2) Potentiates Invasion and Migration of Melanoma by EMT and Wnt/β-Catenin Pathway.

Med Sci Monit 2020 May 28;26:e923808. Epub 2020 May 28.

Department of Plastic Surgery, The Second Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).

BACKGROUND Growing evidence indicates an association between microfibril-associated protein 2 (MFAP2) and a number of physiological and pathological mechanisms. The potential role of MFAP2 in cancer requires further elucidation. The present study investigated the biological behavior of MFAP2 in melanoma patients. Read More

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http://dx.doi.org/10.12659/MSM.923808DOI Listing

Gene Expression Profiling of Human Adipose Tissue Stem Cells during 2D versus 3D Adipogenesis.

Cells Tissues Organs 2020 May 28:1-21. Epub 2020 May 28.

Department of Biomedical, Industrial, and Human Factors Engineering, Wright State University, Dayton, Ohio, USA,

Much of the current understanding on molecular and cellular events of adipose developmental biology comes from monolayer cell culture models using preadipocyte cell lines, although in vivo adipose tissue consists of a much more complex three-dimensional microenvironment of diverse cell types, extracellular network, and tissue-specific morphological and functional features. Added to this fact, the preadipocytes, on which the adipogenesis mechanisms are mostly explored, possess some serious limitations (e.g. Read More

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http://dx.doi.org/10.1159/000507187DOI Listing

Rate-dependent force-extension models for single-molecule force spectroscopy experiments.

Phys Biol 2020 May 28. Epub 2020 May 28.

IEMN, Villeneuve-d'Ascq, 59655, FRANCE.

Single-molecule force spectroscopy (SMFS) techniques allow for the measurements of several static and dynamic features of macromolecules of biological origin. In particular, the atomic force microscopy (AFM), used with a variable pulling rate, provides valuable information on the folding/unfolding dynamics of proteins. We propose here two different models able to describe the out-of-equilibrium statistical mechanics of a chain composed of bistable units. Read More

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http://dx.doi.org/10.1088/1478-3975/ab97a8DOI Listing

CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.

iScience 2020 May 15;23(6):101163. Epub 2020 May 15.

Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; Institut National de la Santé et de la Recherche Médicale (Inserm), Languedoc Roussillon, France. Electronic address:

Cyclin-dependent kinases (CDKs) are emerging regulators of adipose tissue metabolism. Here we aimed to explore the role of CDK7 in thermogenic fat. We found that CDK7 brown adipose tissue (BAT)-specific knockout mice (Cdk7) have decreased BAT mass and impaired β3-adrenergic signaling and develop hypothermia upon cold exposure. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101163DOI Listing

Insights into Manipulating Postprandial Energy Expenditure to Manage Weight Gain in Polycystic Ovary Syndrome.

iScience 2020 May 15;23(6):101164. Epub 2020 May 15.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK. Electronic address:

Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energy expenditure. We used a clinically realistic preclinical model to investigate the molecular basis for the reduced postprandial thermogenesis (PPT) and develop a therapeutic strategy to normalize this deficit. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101164DOI Listing

Hormonal seed-priming improves tomato resistance against broomrape infection.

J Plant Physiol 2020 May 11;250:153184. Epub 2020 May 11.

Integrated Molecular Plant Physiology Research, Department of Biology, University of Antwerp, Antwerp, Belgium; Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

Although it is well known that parasitic weeds such as Orobanche (broomrape) significantly reduce the yield of economically important crops, their infection-induced oxidative changes need more exploration in their host plants. Moreover, applying an eco-friendly approach to minimize the infection is not yet available. This study was conducted to understand the effect of Orobanche ramosa infection on oxidative and redox status of tomato plants and the impact of hormonal (indole acetic acid (IAA); 0. Read More

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http://dx.doi.org/10.1016/j.jplph.2020.153184DOI Listing

The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic.

Mult Scler Relat Disord 2020 May 12;43:102174. Epub 2020 May 12.

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, E1 2AT; United Kingdom; Clinical Board:Medicine (Neuroscience), The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.

Background: SARS-CoV-2 viral infection causes COVID-19 that can result in severe acute respiratory distress syndrome (ARDS), which can cause significant mortality, leading to concern that immunosuppressive treatments for multiple sclerosis and other disorders have significant risks for both infection and ARDS.

Objective: To examine the biology that potentially underpins immunity to the SARS-Cov-2 virus and the immunity-induced pathology related to COVID-19 and determine how this impinges on the use of current disease modifying treatments in multiple sclerosis.

Observations: Although information about the mechanisms of immunity are scant, it appears that monocyte/macrophages and then CD8 T cells are important in eliminating the SARS-CoV-2 virus. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102174DOI Listing

A radiomics-based model for prediction of lymph node metastasis in gastric cancer.

Eur J Radiol 2020 May 18;129:109069. Epub 2020 May 18.

Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Hexi District, Tianjin 300060, China; National Clinical Research Center for Cancer, Huanhuxi Road, Hexi District, Tianjin 300060, China; Tianjin's Clinical Research Center for Cancer, Huanhuxi Road, Hexi District, Tianjin 300060, China; The Key Laboratory of Cancer Prevention and Therapy, Huanhuxi Road, Hexi District, Tianjin 300060, China. Electronic address:

Purpose: To develop and validate a radiomics-based model for preoperative prediction of lymph node metastasis (LNM) in gastric cancer (GC).

Method: A total of 768 GC patients were enrolled in this retrospective study. Radiomics features were extracted from portal venous phase computed tomography (CT) scans. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109069DOI Listing

Communication of plants with microbial world: Exploring the regulatory networks for PGPR mediated defense signaling.

Microbiol Res 2020 May 1;238:126486. Epub 2020 May 1.

Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, 60800 Multan, Pakistan. Electronic address:

Agricultural manipulation of potentially beneficial rhizosphere microbes is increasing rapidly due to their multi-functional plant-protective and growth related benefits. Plant growth promoting rhizobacteria (PGPR) are mostly non-pathogenic microbes which exert direct benefits on plants while there are rhizosphere bacteria which indirectly help plant by ameliorating the biotic and/or abiotic stress or induction of defense response in plant. Regulation of these direct or indirect effect takes place via highly specialized communication system induced at multiple levels of interaction i. Read More

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http://dx.doi.org/10.1016/j.micres.2020.126486DOI Listing

Biological effects, including oxidative stress and genotoxic damage, of polystyrene nanoparticles in different human hematopoietic cell lines.

J Hazard Mater 2020 May 15;398:122900. Epub 2020 May 15.

Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Carlos III Institute of Health, Madrid, Spain. Electronic address:

In recent years the terms "micro-/nanoplastics" (MNPLs) have caught special attention due to the increasing levels by which humans are exposed. Among MNPLs, polystyrene nanoparticles (PSNPs) are one of the most represented MNPLs in the environment. These tiny particles may enter into the human body, translocate through human barriers, interacting with blood and lymphatic immune cells, and reaching secondary organs. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122900DOI Listing

Perchlorate bioreduction by anaerobic granular sludge immobilised with Fe-HA complex: Performance, extracellular polymeric substances and microbial community structure.

J Hazard Mater 2020 May 15;398:122898. Epub 2020 May 15.

School of Environmental Science and Engineering Pollution Prevention Biotechnology Laboratory of Hebei Province, Hebei University of Science and Technology, Yuhua East Road 70#, Shijiazhuang, 050018, PR China.

An iron-humic acid (Fe-HA) complex was used as a redox mediator in perchlorate (ClO) bioreduction. Bioreduction performance, extracellular polymeric substances (EPS), and microbial community structure were comprehensively explored using different types of anaerobic granular sludge (AnGS) immobilised without the Fe-HA complex (AnGS) and with the Fe-HA complex (AnGS). The ClO was completely removed by AnGS by day 20, while the ClO was completely removed by AnGS by day 6. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122898DOI Listing

Role of ANKHD1/LINC00346/ZNF655 Feedback Loop in Regulating the Glioma Angiogenesis via Staufen1-Mediated mRNA Decay.

Mol Ther Nucleic Acids 2020 May 12;20:866-878. Epub 2020 May 12.

Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, China; Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang 110004, China; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang 110004, China. Electronic address:

Accumulating evidence shows that long noncoding RNA (lncRNA) dysregulation plays a critical role in tumor angiogenesis. Glioma is characterized by abundant angiogenesis. Herein, we investigated the expression and function of LINC00346 in the regulation of glioma angiogenesis. Read More

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http://dx.doi.org/10.1016/j.omtn.2020.05.004DOI Listing

lncRNA LINC00665 Stabilized by TAF15 Impeded the Malignant Biological Behaviors of Glioma Cells via STAU1-Mediated mRNA Degradation.

Mol Ther Nucleic Acids 2020 May 8;20:823-840. Epub 2020 May 8.

Department of Neurobiology, School of Life Sciences, China Medical University, Shenyang 110122, China; Key Laboratory of Cell Biology, Ministry of Public Health of China, China Medical University, Shenyang 110122, China; Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang 110122, China. Electronic address:

Glioma is a brain cancer characterized by strong invasiveness with limited treatment options and poor prognosis. Recently, dysregulation of long non-coding RNAs (lncRNAs) has emerged as an important component in cellular processes and tumorigenesis. In this study, we demonstrated that TATA-box binding protein associated factor 15 (TAF15) and long intergenic non-protein coding RNA 665 (LINC00665) were both downregulated in glioma tissues and cells. Read More

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http://dx.doi.org/10.1016/j.omtn.2020.05.003DOI Listing

The reference genome of the selfing fish Kryptolebias hermaphroditus: Identification of phases I and II detoxification genes.

Comp Biochem Physiol Part D Genomics Proteomics 2020 Apr 12;35:100684. Epub 2020 Apr 12.

Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:

The selfing fish Kryptolebias hermaphroditus has unique reproductive system for self-fertilization, making genetically homozygous offsprings. Here, we report on high density genetic map-based genome assembly for the K. hermaphroditus Panama line (PanRS). Read More

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http://dx.doi.org/10.1016/j.cbd.2020.100684DOI Listing
April 2020
2.055 Impact Factor

The role of cortisol in trust behavior: Results from an experimental study on healthy controls and patients with juvenile myoclonic epilepsy.

Epilepsy Behav 2020 May 25;110:107138. Epub 2020 May 25.

Department of Neurology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria. Electronic address:

Trust is one of the foundations of human society and pervades all aspects of human live. Research on humans focused primarily on identifying the biological basis of trust behavior in healthy subjects, and this evidence hints to certain brain areas, hormones, and genetic factors to be fundamentally involved. The contribution of cortisol in trust has not yet elicited much attention in research, especially when specifically examined at basal cortisol levels. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107138DOI Listing

Association of common genetic variants with vitamin D status in Malaysian children with epilepsy.

Seizure 2020 May 20;79:103-111. Epub 2020 May 20.

Paediatric Department, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia.

Purpose: Children with epilepsy (CWE) are at risk of vitamin D deficiency. Single nucleotide polymorphisms (SNPs) affecting the vitamin D pathway are potentially important risk factors for serum 25-hydroxyvitamin D [25(OH)D] concentration. The aims of our study were to evaluate the association of vitamin d-related SNPs to serum 25(OH)D concentrations in Malaysian CWE. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.05.009DOI Listing

Editorial for the Special Issue of Bioelectrochemistry.

Bioelectrochemistry 2020 May 16;135:107555. Epub 2020 May 16.

Institute of Pharmacology and Structural Biology - CNRS, University of Toulouse, France. Electronic address:

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http://dx.doi.org/10.1016/j.bioelechem.2020.107555DOI Listing

Arthropod biodiversity patterns point to the Mesovoid Shallow Substratum (MSS) as a climate refugium.

Zoology (Jena) 2020 Apr 25;141:125771. Epub 2020 Apr 25.

Research Team on Soil Biology and Subterranean Ecosystems, Department of Life Science, Faculty of Science, University Campus, University of Alcalá, A.P. 20, E-28871, Alcalá de Henares, Madrid, Spain.

The determinants of biodiversity patterns in the subterranean habitat called Mesovoid Shallow Substratum (MSS) are not well-understood. In this study, thirty-three scree slopes at high altitudes were selected across the Sierra de Guadarrama National Park in central Spain to investigate the effect of ten environmental variables on the abundance and species diversity of the spider and springtail assemblages from the colluvial MSS. In each locality, a multiperforated PVC tube with a pitfall trap inside was buried up to 1 m deep, and generalized linear models and Mantel tests were used to analyze the effect of mainly climate- and habitat-related variables on the diversity patterns of both taxa. Read More

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http://dx.doi.org/10.1016/j.zool.2020.125771DOI Listing

A H NMR-based metabolomic approach to study the production of antimalarial compounds from Psiadia arguta leaves (pers.) voigt.

Phytochemistry 2020 May 25;176:112401. Epub 2020 May 25.

UMR Qualisud, Université de La Réunion, 15 Avenue René Cassin, CS 92 003, 97 744, St Denis Cedex 9, La Réunion, France. Electronic address:

Psiadia arguta (Asteraceae) is endemic to the island of Mauritius in the Indian Ocean. The species is traditionally used to treat various ailments, such as its use as an expectorant or for the treatment of bronchitis and asthma. Preliminary biological screenings have displayed the antimalarial (Plasmodium falciparum) and anticancer (HeLa human cell line) potential of P. Read More

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http://dx.doi.org/10.1016/j.phytochem.2020.112401DOI Listing

Genetic variation in SARS-CoV-2 may explain variable severity of COVID-19.

Med Hypotheses 2020 May 24;143:109877. Epub 2020 May 24.

Department of Biochemistry, Kumudini Women's Medical College, Mirzapur, Tangail, Bangladesh.

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http://dx.doi.org/10.1016/j.mehy.2020.109877DOI Listing

Molybdenum-induced effects on leaf ultra-structure and rhizosphere phosphorus transformation in Triticum aestivum L.

Plant Physiol Biochem 2020 May 16;153:20-29. Epub 2020 May 16.

Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtze River), Ministry of Agriculture, Micro-elements Research Center, College of Resource and Environment, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Provincial Engineering Laboratory for New Fertilizers, Huazhong Agricultural University, Wuhan, 430070, China; Department of Crop Science and Technology, College of Agriculture, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

Soil phosphorus (P) occurs in pools of lower availability due to soil P fixation and therefore, it is a key constrain to crop production. Long term molybdenum-induced effects in wheat and rhizosphere/non-rhizosphere soil P dynamics have not yet been investigated. Here, a long term field experiment was conducted to explore these effects in wheat consisting of two treatments i. Read More

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http://dx.doi.org/10.1016/j.plaphy.2020.05.010DOI Listing

Genetic underpinnings of cerebral edema in acute brain injury: an opportunity for pathway discovery.

Neurosci Lett 2020 May 25;730:135046. Epub 2020 May 25.

Division of Neurocritical Care & Emergency Neurology, Department of Neurology, Yale School of Medicine, 15 York Street, LLCI Room 1004D, P.O. Box 20801, New Haven, CT 06510, USA. Electronic address:

Cerebral edema constitutes an important contributor to secondary injury in acute brain injury. The quantification of cerebral edema in neuroimaging, a well-established biomarker of secondary brain injury, represents a useful intermediate phenotype to study edema formation. Population genetics provides powerful tools to identify novel susceptibility genes, biological pathways and therapeutic targets related to brain edema formation. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135046DOI Listing

Advances in adjuvant therapy of biliary tract cancer: an overview of current clinical evidence based on phase II and III trials.

Crit Rev Oncol Hematol 2020 Apr 27;151:102975. Epub 2020 Apr 27.

Amsterdam UMC, Dept. of Medical Oncology, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands. Electronic address:

Patients with biliary tract cancer (BTC) have a high recurrence rate after complete surgical resection. To reduce the risk of recurrence and to improve survival, several chemotherapeutic agents that have shown to be active in locally advanced and metastatic BTC have been investigated in the adjuvant setting in prospective clinical trials. Based on the results of the BILCAP phase III trial, capecitabine was adapted as the standard of care by the ASCO clinical practice guideline. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102975DOI Listing

Recent advances on the plant manipulation by geminiviruses.

Curr Opin Plant Biol 2020 May 25;56:56-64. Epub 2020 May 25.

Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, China. Electronic address:

As intracellular parasites, viruses co-opt the molecular machinery of the cells they infect in order to multiply and spread, and the extensiveness and effectiveness of this manipulation ultimately determine the outcome of the interaction between virus and host. Members of the Geminiviridae family, causal agents of devastating diseases in crops, encode only a handful of multifunctional, fast-evolving proteins, which efficiently target host proteins to re-wire plant development and physiology and enable replication and spread of the viral genome. In this review, we offer an overview of the different steps in the geminiviral invasion of the host plant, and explore the knowns and unknowns in geminivirus biology. Read More

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http://dx.doi.org/10.1016/j.pbi.2020.03.009DOI Listing

Cysteamine triggered "turn-on" fluorescence sensor for total detection of fumonisin B, B and B.

Food Chem 2020 May 18;327:127058. Epub 2020 May 18.

College of Animal Sciences/ College of Life Science, Yangtze University, Jingzhou 434023, China. Electronic address:

A "turn-on" fluorescence sensor was developed for total detection of fumonisin B, B and B (FB, FB and FB) in maize samples. Rhodamine B isothiocyanate (RBITC) and gold nanoparticles (AuNPs) were employed as the energy donor-acceptor pairs. The intensity of restored fluorescence was inversely proportional to the concentration of the FBs. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127058DOI Listing

A new method for three-dimensional immunofluorescence study of the cochlea.

Hear Res 2020 May 5;392:107956. Epub 2020 May 5.

Otolaryngology, Department of Surgery, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia. Electronic address:

Visualisation of cochlear histopathology in three-dimensions has been long desired in the field of hearing research. This paper outlines a technique that has made this possible and shows a research application in the field of hearing protection after cochlear implantation. The technique utilises robust immunofluorescent labelling followed by effective tissue clearing and fast image acquisition using Light Sheet Microscopy. Read More

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http://dx.doi.org/10.1016/j.heares.2020.107956DOI Listing

Toxicity assessment of two-dimensional nanomaterials molybdenum disulfide in Gallus gallus domesticus.

Ecotoxicol Environ Saf 2020 May 25;200:110772. Epub 2020 May 25.

Department of Biological, Geological and Environmental Science, University of Catania, Catania, Italy. Electronic address:

Recently two-dimensional nanomaterials, such as graphene and molybdenum disulfide (MoS), have received much attention as adsorbent materials for the effective removal of organic contaminants. MoS is attracting attention, not only for its chemical-physical properties, but also for its wide availability in nature as a constituent of molybdenite. The aim of this investigation was to assess the effects of different MoS concentrations (5 × 10, 5 × 10 and 5 × 10 mg/ml) on the embryonated eggs of Gallus gallus domesticus, according to Beck method. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110772DOI Listing

Curcumin alleviates arsenic-induced toxicity in PC12 cells via modulating autophagy/apoptosis.

Ecotoxicol Environ Saf 2020 May 25;200:110756. Epub 2020 May 25.

Graduate School of Environmental Science, Hokkaido University, Sapporo, 060-0810, Japan; Faculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan. Electronic address:

Arsenic is a recognized highly toxic contaminant, responsible for numerous human diseases and affecting many millions of people in different parts of the world. Contrarily, curcumin is a natural dietary polyphenolic compound and the main active ingredient in turmeric. Recently it has drawn great attention due to its diverse biological activities, strong antioxidant properties and therapeutic potential against many human ailments. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110756DOI Listing

Pesticide bioremediation in liquid media using a microbial consortium and bacteria-pure strains isolated from a biomixture used in agricultural areas.

Ecotoxicol Environ Saf 2020 May 25;200:110734. Epub 2020 May 25.

Facultad de Ingeniería, Universidad Autónoma de Yucatán, Av. Industrias No Contaminantes por Anillo Periférico Norte S/n. Apdo. Postal 150 Cordemex. Cd, Mérida, Yucatán, Mexico.

Microorganisms' role in pesticide degradation has been studied widely. Insitu treatments of effluents containing pesticides such as biological beds (biobeds) are efficient biological systems where biomixture (mixture of substrates) and microorganisms are the keys in pesticide treatment; however, microbial activity has been studied poorly, and its potential beyond biobeds has not been widely explored. In this study, the capacity of microbial consortium and bacteria-pure strains isolated from a biomixture (soil-straw; 1:1, v/v) used to treat agricultural effluents under real conditions were evaluated during a bioremediation process of five pesticides commonly used Yucatan Mexico. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110734DOI Listing

Overexpression of rice glutaredoxin genes LOC_Os02g40500 and LOC_Os01g27140 regulate plant responses to drought stress.

Ecotoxicol Environ Saf 2020 May 25;200:110721. Epub 2020 May 25.

CSIR-National Botanical Research Institute, Lucknow, 226001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address:

Glutaredoxins (Grxs) are small (10-15 kDa) glutathione (GSH) - dependent redox proteins. The role of Grxs are well documented in tolerance to heavy metal stress in prokaryotic and mammalian systems and a few plant genera, but is poorly understood in plants against drought. In the present study, two rice glutaredoxin (Osgrx) genes (LOC_Os02g40500 and LOC_Os01g27140) responsible for tolerance against heavy metal stress have been studied for investigating their role against drought. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110721DOI Listing

Role of arginine kinase in Paramecium tetraurelia (Ciliophora, Peniculida): Subcellular localization of AK3 and phosphoarginine shuttle system in cilia.

Eur J Protistol 2020 Apr 23;74:125705. Epub 2020 Apr 23.

Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Science and Technology, Kochi University, Kochi 780-8520, Japan.

The ciliate Paramecium tetraurelia has four arginine kinase genes (AK1, AK2, AK3, and AK4). Of these genes, only AK3 has a signal sequence for farnesylation, a post-translational modification that enables anchoring of the modified enzyme to the ciliary membrane. To confirm this modification, AK3 was synthesized using a cell-free protein synthesis system and the peptide masses were analyzed using peptide mass fingerprinting (PMF). Read More

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http://dx.doi.org/10.1016/j.ejop.2020.125705DOI Listing

Docosahexaenoic acid and oleic acid induce altered DNA methylation of individual CpG loci in Jurkat T cells.

Prostaglandins Leukot Essent Fatty Acids 2020 May 21;158:102128. Epub 2020 May 21.

School of Human Development and Health, Faculty of Medicine, Institute of Developmental Sciences Building (MP887), University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK. Electronic address:

Docosahexaenoic acid (DHA, 22:6n-3) and oleic acid (18:1n-9) can alter the DNA methylation of individual CpG loci in vivo and in vitro, although the targeting mechanism is unknown. We tested the hypothesis that the targeting of altered methylation is associated with putative transcription factor response elements (pTREs) proximal to modified loci. Jurkat cells were treated with 22:6n-3 or 18:1n-9 (both 15 μM) for eight days and DNA methylation measured using the MethylationEPIC 850K array. Read More

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http://dx.doi.org/10.1016/j.plefa.2020.102128DOI Listing

Corrigendum to "A rapid and inexpensive viability assay for zoospores and zoosporangia of Batrachochytrium dendrobatidis" [Journal of Microbiological Methods 165 (2019) 105688].

J Microbiol Methods 2020 May 25;174:105945. Epub 2020 May 25.

Molecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, Australia.

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http://dx.doi.org/10.1016/j.mimet.2020.105945DOI Listing

Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents.

Eur J Med Chem 2020 May 1;198:112396. Epub 2020 May 1.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, PR China. Electronic address:

A novel series of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents were designed, synthesized, biologically evaluated. Compounds 3n, 3o and 3j proved to be good NQO1 substrates that showed increased metabolic rates relative to that of β-lapachone. In addition, 3n, 3o and 3j potently inhibited the growth of NQO1-rich breast cancer MCF-7 cell, liver hepatocellular HepG2 cell, and lung cancer A549 cell. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112396DOI Listing

Hypoxia responsiveness linked variant in EGLN1 gene is enriched in oral cancer patients.

Arch Oral Biol 2020 May 19;116:104767. Epub 2020 May 19.

Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India. Electronic address:

Objective: The aim of this study was to determine the association of EGLN1 gene variant SNP rs479200 (T > C) with the risk of oral cancer.

Materials And Methods: A case-control study was conducted by involving 103 oral cancer patients and 206 age and gender-matched healthy controls. SNP rs479200 was genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104767DOI Listing

Design, synthesis and anticancer/antiestrogenic activities of novel indole-benzimidazoles.

Bioorg Chem 2020 May 17;100:103929. Epub 2020 May 17.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Ankara, Turkey. Electronic address:

Indole-benzimidazoles have recently gained attention due to their antiproliferative and antiestrogenic effects. However, their structural similarities and molecular mechanisms shared with selective estrogen receptor modulators (SERMs) have not yet been investigated. In this study, we synthesized novel ethylsulfonyl indole-benzimidazole derivatives by substituting the first (R) and fifth (R) positions of benzimidazole and indole groups, respectively. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103929DOI Listing
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