3,030,307 results match your criteria Biological & pharmaceutical bulletin[Journal]


Eating behaviour and oxytocin in patients with childhood-onset craniopharyngioma and different grades of hypothalamic involvement.

Pediatr Obes 2019 Apr 23:e12527. Epub 2019 Apr 23.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, Carl von Ossietzky University, Oldenburg, Germany.

Background: Patients with childhood-onset craniopharyngioma (CP) often suffer from tumour or treatment-related hypothalamic lesions (HL). These lesions may alter production of oxytocin, which plays a major role in the regulation of eating behaviour and body composition.

Objective: In CP with different degrees of HL, we investigated associations between HL, eating behaviour/eating attitudes, and oxytocin saliva concentrations (OSC). Read More

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http://dx.doi.org/10.1111/ijpo.12527DOI Listing

Biocatalytic Reversal of Advanced Glycation End Product Modification.

Chembiochem 2019 Apr 23. Epub 2019 Apr 23.

Yale, Chemistry and Microbial Pathogenesis, P.O. Box 27392, 06516-7392, West Haven, UNITED STATES.

Advanced glycation end products (AGEs) are a heterogeneous group of molecules that emerge from the condensation of sugars and proteins via the Maillard reaction. Despite a significant number of studies showing strong associations between AGEs and the pathologies of aging-related illnesses, it has been a challenge to establish AGEs as causal agents primarily due to the lack of tools in reversing AGE modifications at the molecular level. Here, we show that MnmC, an enzyme involved in a bacterial tRNA-modification pathway, is capable of reversing the AGEs carboxyethyl-lysine (CEL) and carboxymethyl-lysine (CML) back to their native lysine structure. Read More

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http://dx.doi.org/10.1002/cbic.201900158DOI Listing

Habitat edge responses of generalist predators are predicted by prey and structural resources.

Ecology 2019 Apr 23:e02662. Epub 2019 Apr 23.

Department of Biological Sciences, University of Denver, Denver, Colorado, 80208, USA.

Generalist predators are thought to be less vulnerable to habitat fragmentation because they use diverse resources across larger spatial scales than specialist predators. Thus, it has been suggested that generalist predators may respond positively to habitat edges or demonstrate no edge response, because they can potentially use prey resources equally well on both sides of the habitat edge. However, most predictions about generalist predator responses to the habitat edge are based solely on prey resources, without consideration of other potential drivers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ecy.2662
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http://dx.doi.org/10.1002/ecy.2662DOI Listing
April 2019
2 Reads

Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports.

Int J Sports Med 2019 Apr 23. Epub 2019 Apr 23.

Hull York Medical School, Centre for Atherothrombotic and Metabolic Disease, Hull, United Kingdom of Great Britain and Northern Ireland.

Platelet-based applications are currently used for the delivery of growth factors and other biomolecules as autologous biomaterials in regenerative medicine and cosmetic therapies. Many studies have revealed that platelet-based applications such as platelet-rich plasma and platelet releasate exhibit beneficial biological effects after a sports injury or trauma when administered locally by intramuscular injections. At present, treatment of the public, patients and athletes with platelet-based applications is permitted and regulated by the Food and Drug Administration and the World Anti-Doping Agency. Read More

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http://dx.doi.org/10.1055/a-0884-0734DOI Listing

Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth.

Fetal Diagn Ther 2019 Apr 23:1-10. Epub 2019 Apr 23.

Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia,

Objective: The aim of this study was to investigate the potential utility of serum HtrA1 and HtrA3, serine proteases that are highly expressed in the developing placenta, at 15 and 20 weeks of gestation for predicting later development of adverse pregnancy outcomes of preeclampsia (PE), gestational hypertension (GHT), preterm birth (PTB), and small for gestational age (SGA) birth.

Methods: This is a nested case control study of 665 samples (330 controls, 335 cases) from the Adelaide SCOPE cohort. The cases included were 92 PE, 71 GHT, 56 PTB, and 116 SGA. Read More

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http://dx.doi.org/10.1159/000497144DOI Listing

Effect of Circadian Rhythm on Metabolic Processes and the Regulation of Energy Balance.

Ann Nutr Metab 2019 Apr 23;74(4):322-330. Epub 2019 Apr 23.

Faculty of Health Sciences, Department of Nutrition and Dietetic, Gazi University, Ankara, Turkey,

Background: The circadian timing system or circadian clock plays a crucial role in many biological processes, such as the sleep-wake cycle, hormone secretion, cardiovascular health, glucose homeostasis, and body temperature regulation. Energy balance is also one of the most important cornerstones of metabolic processes, whereas energy imbalance is associated with many diseases (i.e. Read More

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https://www.karger.com/Article/FullText/500071
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http://dx.doi.org/10.1159/000500071DOI Listing
April 2019
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Reproductive science and the future of the planet.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

B Wong, School of Biological Sciences, Monash University, Clayton, Australia.

Reproductive sciences have made major contributions to human health, livestock production and environmental management in the past and will continue to do so in future. In collaboration with other disciplines, reproductive scientists can provide scientifically valid information that will allow the rational development of policies on topics such as declining fertility in men and women, livestock breeding efficiencies, climate change, pest animal control, wildlife management and environmental influences. It is imperative that the reproductive sciences are recognised by the community and policy makers as important contributors to future health and welfare of animals, humans and the planet if these potential benefits are to be captured and utilized. Read More

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http://dx.doi.org/10.1530/REP-18-0640DOI Listing

Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

K Chapman, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom of Great Britain and Northern Ireland.

Endogenous glucocorticoid action is important in the structural and functional maturation of the fetal heart. In fetal mice, although glucocorticoid concentrations are extremely low before E14.5, glucocorticoid receptor (GR) is expressed in the heart from E10. Read More

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http://dx.doi.org/10.1530/JOE-18-0666DOI Listing

Twisting the bone marrow stem cell niche.

Haematologica 2018 Dec 30;103(12):1937-1939. Epub 2018 Nov 30.

Division of Experimental Hematology and Cancer Biology, Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati.

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http://dx.doi.org/10.3324/haematol.2018.206029DOI Listing
December 2018

DIY Automated Feeding and Motion Recording System for the Analysis of Fish Behavior.

SLAS Technol 2019 Apr 23:2472630319841412. Epub 2019 Apr 23.

2 Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany.

Fish species such as medaka or zebrafish are widely used as animal models to study physiology, disease development, and treatment efficacy. They are also used to study the rapidly growing field of behavior research, such as social interactions, anxiety, and the influence of environmental factors. Here we describe an automated experimental setup allowing the recording of general locomotor activity in combination with a food-on-demand system. Read More

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http://dx.doi.org/10.1177/2472630319841412DOI Listing

Ameliorative Effects of on Cognitive Impairment Via Enhancing Cholinergic Functions and Brain-Derived Neurotrophic Factor Expression in -Amyloid-Induced Mice.

J Med Food 2019 Apr 23. Epub 2019 Apr 23.

1 Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Brain Korea 21 Project for Medical Sciences, Severance Medical Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Alzheimer's disease accounts for the majority of dementia and shows hallmarks such as sequential cognitive dysfunction and abnormal behavior. (DM) has traditionally been used to treat a variety of diseases in East Asia. The aim of this study was to assess the therapeutic effects of DM on brain neuron damage and on cognitive deficit in neuronal cell induced by A in mice. Read More

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http://dx.doi.org/10.1089/jmf.2018.4375DOI Listing

Mechanisms by Which the Gut Microbiota Influences Cytokine Production and Modulates Host Inflammatory Responses.

J Interferon Cytokine Res 2019 Apr 23. Epub 2019 Apr 23.

1 Laboratory of Microbiota and Immunomodulation, Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

The gastrointestinal tract encounters a wide variety of microorganisms, including beneficial symbionts, pathobionts, and pathogens. Recent evidence has shown that the gut microbiota, directly or indirectly through its components, such as metabolites, actively participates in the host inflammatory response by cytokine-microbiota or microbiota-cytokine modulation interactions, both in the gut and systemically. Therefore, further elucidation of host cytokine molecular pathways and microbiota components will provide a novel and promising therapeutic approach to control or prevent inflammatory disease and to maintain host homeostasis. Read More

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http://dx.doi.org/10.1089/jir.2019.0011DOI Listing

Monocyte Production of IFN-γ Is Interleukin-12 Dependent in a Model of Mevalonate Kinase Deficiency.

J Interferon Cytokine Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Biology, Dickinson College, Carlisle, Pennsylvania.

Mevalonate Kinase Deficiency (MKD) is an autoinflammatory disease caused by mutations in the mevalonate kinase gene, which produces an enzyme responsible for the production of isoprenoids in the mevalonate pathway. Patient data indicate that MKD is a multicytokine disease with increased plasma levels of cytokines such as tumor necrosis factor-α, interleukin (IL)-6, and interferon (IFN)-γ. To study the mechanisms responsible for these changes, the mevalonate pathway was inhibited with lovastatin in peripheral blood mononuclear cells (PBMCs) and monocytes isolated from the blood of healthy donors followed by stimulation with lipopolysaccharide (LPS) to induce an inflammatory response. Read More

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http://dx.doi.org/10.1089/jir.2018.0126DOI Listing

Propofol promotes apoptosis of colorectal cancer cells via alleviating the suppression of lncRNA HOXA11-AS on miRNA let-7i.

Biochem Cell Biol 2019 Apr 23. Epub 2019 Apr 23.

The First Affiliated Hospital of Zhengzhou University , No.1, East Jianshe Road, Erqi District , Zhengzhou , China , 450052 ;

Recently, surgical resection is still the mainstay for colorectal cancer (CRC) treatment. Propofol (2,6-diisopropylphenol), one of the most commonly used intravenous anaesthetic agents, has been reported to be involved in modulating the malignancy of a variety of human cancers. However, the underlying mechanisms remain poorly understood. Read More

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http://dx.doi.org/10.1139/bcb-2018-0235DOI Listing

Kinetics of In Vitro Guanine- N7-Alkylation in Calf Thymus DNA by (2 S,3 S)-1,2-Epoxybutane-3,4-Diol 4-Methanesulfonate and (2 S,3 S)-1,2:3,4-Diepoxybutane: Revision of the Mechanism of DNA Cross-linking by the Prodrug Treosulfan.

Mol Pharm 2019 Apr 23. Epub 2019 Apr 23.

Prodrug treosulfan, originally registered for treatment of ovarian cancer, has gained a use in conditioning prior to hematopoietic stem cell transplantation. Treosulfan converts nonenzymatically to the monoepoxide intermediate (EBDM), and then to (2 S,3 S)-1,2:3,4-diepoxybutane (DEB). The latter alkylates DNA forming mainly (2' S,3' S)- N-7-(2',3',4'-trihydroxybut-1'-yl)guanine (THBG) and (2 S,3 S)-1,4-bis-(guan-7'-yl)-2,3-butane-2,3-diol cross-link (bis-N7G-BD) via the intermediate epoxide adduct (EHBG). Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00251DOI Listing

The optimization of sintering treatment on bovine-derived bone grafts for bone regeneration: in vitro and in vivo evaluation.

J Biomed Mater Res B Appl Biomater 2019 Apr 23. Epub 2019 Apr 23.

Department of Prothodontics, The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Modifications of sintering temperature and treatment time of bovine-derived bone grafts affect their physicochemical properties and further influence biological activity. Three different temperature sintered bovine-derived bone grafts: group I (300 °C 3 h), group II (300 °C 3 h plus 530 °C 6 h), and group III (300 °C 3 h plus 1000 °C 2 h) and Bio-Oss® were characterized and then compared in vitro for their effects on bone marrow stromal cells (BMSCs) migration, proliferation, and differentiation as estimated by cell migration assay, Alkaline phosphatase (ALP) activity assay, and Alizarin red staining. Further, the four bone grafts were implanted into the calvarial defects of rabbits to evaluate bone regeneration and graft degradation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.34387
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http://dx.doi.org/10.1002/jbm.b.34387DOI Listing
April 2019
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Small alarmones (p)ppGpp regulate virulence associated traits and pathogenesis of Salmonella enterica serovar Typhi.

Cell Microbiol 2019 Apr 23:e13034. Epub 2019 Apr 23.

Division of Clinical Medicine, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.

How Salmonella enterica serovar Typhi (S. Typhi), an important human pathogen survives the stressful microenvironments inside the gastrointestinal tract and within macrophages remains poorly understood. We report here that S. Read More

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http://dx.doi.org/10.1111/cmi.13034DOI Listing

Landscape genomic signatures indicate reduced gene flow and forest-associated adaptive divergence in an endangered neotropical turtle.

Mol Ecol 2019 Apr 23. Epub 2019 Apr 23.

Department of Ecology and Evolutionary Biology, La Kretz Center for California Conservation Science, and Institute of the Environment and Sustainability, University of California, Los Angeles, CA, 90095, USA.

Human-induced transformations of ecosystems usually result in fragmented populations subject to increased extinction risk. Fragmentation is also often associated with novel environmental heterogeneity, which in combination with restricted gene flow may increase the opportunity for local adaptation. To manage at-risk populations in these landscapes, it is important to understand how gene flow is changing, and how populations respond to habitat loss. Read More

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http://dx.doi.org/10.1111/mec.15112DOI Listing

Graphene Oxide Incorporated Polycaprolactone/Chitosan/Collagen Electrospun Scaffold: Enhanced Osteogenic Properties for Bone Tissue Engineering.

Artif Organs 2019 Apr 23. Epub 2019 Apr 23.

Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.

This in vitro study aimed to evaluate the physicochemical and biological activity of the polycaprolactone/chitosan/collagen scaffolds incorporated with 0, 0.5, 3, and 6 wt% graphene oxide (GO). Using standard tests and MG-63 cells the characteristics of scaffolds were evaluated, and the behavior of osteoblasts were simulated respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/aor.13474
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http://dx.doi.org/10.1111/aor.13474DOI Listing
April 2019
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Microencapsulated Parathyroid Allotransplantation in the Omental Tissue.

Artif Organs 2019 Apr 23. Epub 2019 Apr 23.

Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.

Background: Permanent hypoparathyroidism is a severe clinical condition accompanied by low parathormone level. Conventional treatment requires life-long medication, and daily drug usage has some side-effects. To avoid this circumstance, transplantation is an alternative and curative option. Read More

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http://dx.doi.org/10.1111/aor.13475DOI Listing

Hypertension Contributes to Neuropathy in Patients with Type 1 Diabetes.

Am J Hypertens 2019 Apr 23. Epub 2019 Apr 23.

Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.

Background: Diabetic peripheral neuropathy (DPN) can lead to foot ulceration and amputation. There are currently no disease modifying therapies for DPN. The aim of this study was to determine if hypertension contributes to DPN in patients with T1DM. Read More

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http://dx.doi.org/10.1093/ajh/hpz058DOI Listing

In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus.

PLoS One 2019 23;14(4):e0215960. Epub 2019 Apr 23.

Department of Biology, Memorial University of Newfoundland, St. John's, NL, Canada.

In Streptomyces clavuligerus, the gene cluster involved in the biosynthesis of the clinically used β-lactamase inhibitor clavulanic acid contains a gene (orf12 or cpe) encoding a protein with a C-terminal class A β-lactamase-like domain. The cpe gene is essential for clavulanic acid production, and the recent crystal structure of its product (Cpe) was shown to also contain an N-terminal isomerase/cyclase-like domain, but the function of the protein remains unknown. In the current study, we show that Cpe is a cytoplasmic protein and that both its N- and C-terminal domains are required for in vivo clavulanic acid production in S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215960PLOS

Natural variation in the roles of C. elegans autophagy components during microsporidia infection.

PLoS One 2019 23;14(4):e0216011. Epub 2019 Apr 23.

Division of Biological Sciences, University of California, San Diego, La Jolla, California, United States of America.

Natural genetic variation can determine the outcome of an infection, and often reflects the co-evolutionary battle between hosts and pathogens. We previously found that a natural variant of the nematode Caenorhabditis elegans from Hawaii (HW) has increased resistance against natural microsporidian pathogens in the Nematocida genus, when compared to the standard laboratory strain of N2. In particular, HW animals can clear infection, while N2 animals cannot. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216011PLOS

Effects of the selective inhibition of proteasome caspase-like activity by CLi a derivative of nor-cerpegin in dystrophic mdx mice.

PLoS One 2019 23;14(4):e0215821. Epub 2019 Apr 23.

Sorbonne Université, Institut de Biologie Paris-Seine (IBPS), CNRS UMR 8256, Inserm ERL U1164, Biological Adaptation and Ageing, Paris, France.

Previous studies have shown that proteasome inhibition can have beneficial effects in dystrophic mouse models. In this study, we have investigated the effects of a new selective proteasome inhibitor, CLi, a strong caspase-like inhibitor of the 20S proteasome, on skeletal and cardiac muscle functions of mdx mice. In the first series of experiments, five-month-old male mdx mice (n = 34) were treated with 2 different doses (20 and 100 μg/kg) of CLi and in the second series of experiments, five-month-old female mdx (n = 19) and wild-type (n = 24) mice were treated with 20 μg/kg CLi and Velcade (1 mg/kg) for 1-month. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215821PLOS
April 2019
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Middle-way flexible docking: Pose prediction using mixed-resolution Monte Carlo in estrogen receptor α.

PLoS One 2019 23;14(4):e0215694. Epub 2019 Apr 23.

Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, United States of America.

There is a vast gulf between the two primary strategies for simulating protein-ligand interactions. Docking methods significantly limit or eliminate protein flexibility to gain great speed at the price of uncontrolled inaccuracy, whereas fully flexible atomistic molecular dynamics simulations are expensive and often suffer from limited sampling. We have developed a flexible docking approach geared especially for highly flexible or poorly resolved targets based on mixed-resolution Monte Carlo (MRMC), which is intended to offer a balance among speed, protein flexibility, and sampling power. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215694PLOS
April 2019
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Request a woman scientist: A database for diversifying the public face of science.

PLoS Biol 2019 Apr 23;17(4):e3000212. Epub 2019 Apr 23.

500 Women Scientists, Boulder, Colorado, United States of America.

A global online register of women scientists, ready to share their science, was established by a cohort of volunteer women from the grassroots organization 500 Women Scientists on January 17th, 2018. In less than one year, the database "Request a Woman Scientist" comprised over 7,500 women from 174 scientific disciplines and 133 countries. The database is built upon a voluntary questionnaire regarding career stage, degree, scientific discipline, geographic location, and other self-identifying dimensions of representation. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000212DOI Listing

Identification of key regulatory genes connected to NF-κB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network.

PLoS One 2019 23;14(4):e0214337. Epub 2019 Apr 23.

Center of Excellence in Bionanoscience Research, King Abdulaziz University, Jeddah, Saudi Arabia.

Obesity is connected to the activation of chronic inflammatory pathways in both adipocytes and macrophages located in adipose tissues. The nuclear factor (NF)-κB is a central molecule involved in inflammatory pathways linked to the pathology of different complex metabolic disorders. Investigating the gene expression data in the adipose tissue would potentially unravel disease relevant gene interactions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214337PLOS

Decadal monitoring reveals an increase in Vibrio spp. concentrations in the Neuse River Estuary, North Carolina, USA.

PLoS One 2019 23;14(4):e0215254. Epub 2019 Apr 23.

The University of North Carolina at Chapel Hill, Institute of Marine Sciences; Morehead City, NC, United States of America.

A decade long study was conducted to investigate the ecological, biological, and temporal conditions that affect concentrations of Vibrio spp. bacteria in a well-studied lagoonal estuary. Water samples collected from the Neuse River Estuary in eastern North Carolina from 2004-2014 (with additional follow-up samples from Fall of 2018) were analyzed to determine Vibrio spp. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215254PLOS

Genome-wide association study between CNVs and milk production traits in Valle del Belice sheep.

PLoS One 2019 23;14(4):e0215204. Epub 2019 Apr 23.

Università degli Studi di Palermo, Dipartimento di Scienze Agrarie, Alimentari e Forestali, Italy.

Copy number variation (CNV) is a major source of genomic structural variation. The aim of this study was to detect genomic CNV regions (CNVR) in Valle del Belice dairy sheep population and to identify those affecting milk production traits. The GO analysis identified possible candidate genes and pathways related to the selected traits. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215204PLOS
April 2019
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Deep convolutional models improve predictions of macaque V1 responses to natural images.

PLoS Comput Biol 2019 Apr 23;15(4):e1006897. Epub 2019 Apr 23.

Centre for Integrative Neuroscience and Institute for Theoretical Physics, University of Tübingen, Tübingen, Germany.

Despite great efforts over several decades, our best models of primary visual cortex (V1) still predict spiking activity quite poorly when probed with natural stimuli, highlighting our limited understanding of the nonlinear computations in V1. Recently, two approaches based on deep learning have emerged for modeling these nonlinear computations: transfer learning from artificial neural networks trained on object recognition and data-driven convolutional neural network models trained end-to-end on large populations of neurons. Here, we test the ability of both approaches to predict spiking activity in response to natural images in V1 of awake monkeys. Read More

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http://dx.plos.org/10.1371/journal.pcbi.1006897
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http://dx.doi.org/10.1371/journal.pcbi.1006897DOI Listing
April 2019
1 Read

Properties of face localizer activations and their application in functional magnetic resonance imaging (fMRI) fingerprinting.

PLoS One 2019 23;14(4):e0214997. Epub 2019 Apr 23.

University Department of Psychiatry and Psychotherapy, University Hospital Tuebingen, Tuebingen, Germany.

Functional localizers are particularly prevalent in functional magnetic resonance imaging (fMRI) studies concerning face processing. In this study, we extend the knowledge on face localizers regarding four important aspects: First, activation differences in occipital and fusiform face areas (OFA/FFA) and amygdala are characterized by increased activation while precuneus and medial prefrontal cortex show decreased deactivation to faces versus control stimuli. The face-selective posterior superior temporal sulcus is a hybrid area exhibiting increased activation within its inferior and decreased deactivation within its superior part. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214997PLOS

Biomarkers of endothelial activation/dysfunction distinguish sub-groups of Ugandan patients with sepsis and differing mortality risks.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Background: Sepsis is a complex clinical syndrome with substantial heterogeneity. We sought to identify patterns of serum biomarkers of endothelial activation and dysfunction in individuals with sepsis and evaluate subgroup-specific differences in mortality.

Methods: Adult patients with sepsis (n=426) were consecutively recruited from two hospitals in Uganda. Read More

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http://dx.doi.org/10.1172/jci.insight.127623DOI Listing

Potassium acts through mTOR to regulate its own secretion.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Potassium (K+) secretion by kidney tubule cells is central to electrolyte homeostasis in mammals. In the K+ secretory "principal" cells of the distal nephron, electrogenic Na+ transport by the epithelial sodium channel (ENaC) generates the electrical driving force for K+ transport across the apical membrane. Regulation of this process is attributable in part to aldosterone, which stimulates the gene transcription of the ENaC-regulatory kinase, SGK1. Read More

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http://insight.jci.org/articles/view/126910
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http://dx.doi.org/10.1172/jci.insight.126910DOI Listing

Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization.

Phys Biol 2019 Apr 23;16(4):046004. Epub 2019 Apr 23.

The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London WC1 6BT, United Kingdom.

Active networks composed of filaments and motor proteins can self-organize into a variety of architectures. Computer simulations in two or three spatial dimensions and including or omitting steric interactions between filaments can be used to model active networks. Here we examine how these modelling choices affect the state space of network self-organization. Read More

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http://dx.doi.org/10.1088/1478-3975/ab0fb1DOI Listing

In memoriam of Marvin Zuckerman: His impact on Spanish Psychology.

Authors:
Anton Aluja

Psicothema 2019 May;31(2):184-193

University of Lleida. Catalonia (Spain) and Lleida Institute for Biomedical Research Dr. Pifarré Foundation (IRBLleida).

Background: The work of recently deceased Marvin Zuckerman is well-known in Psychology. Zuckerman is mainly known around the world for describing the nature of the Sensation Seeking personality trait (with a strong biological basis related to physiology, endocrinology, brain biochemistry and genetics), and its practical usefulness in explaining many human behaviors, especially high-risk behaviors.

Method: The article refers to biographical aspects of Zuckerman’s career, and presents and presents an outline of results produced in Spain within the Zuckerman framework. Read More

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http://dx.doi.org/10.7334/psicothema2019.35DOI Listing

Experimental Investigation of Vegetative Environment Buffers in Reducing Particulate Matters Emitted from Ventilated Poultry House.

J Air Waste Manag Assoc 2019 Apr 23. Epub 2019 Apr 23.

a Key Laboratory of Bionic Engineering, (Ministry of Education of China), Jilin University , 5988 Renmin Street, Changchun 130022 , China.

Scientists have effectively proved that vegetative environment buffers (VEB) can be used for reducing dust emissions from livestock buildings, but they have seen fewer tests in poultry farms. A field research was conducted to assess the effectiveness of VEBs on reducing downwind transport of particulate matter (PM) from a ventilated poultry house in Changchun. Five plant species transferred from local area were used to establish five diverse VEBs and separately installed outside of the ventilation fans in summer 2017. Read More

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http://dx.doi.org/10.1080/10962247.2019.1598518DOI Listing

SPLUNC1 Loses its Antimicrobial Activity in Acidic Cystic Fibrosis Airway Secretions.

Am J Respir Crit Care Med 2019 Apr 23. Epub 2019 Apr 23.

University of North Carolina at Chapel Hill, 2331, Department of Cell Biology and Physiology, Chapel Hill, North Carolina, United States.

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https://www.atsjournals.org/doi/10.1164/rccm.201812-2303LE
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http://dx.doi.org/10.1164/rccm.201812-2303LEDOI Listing

Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp.

J Nat Prod 2019 Apr 23. Epub 2019 Apr 23.

Department of Pharmacy, College of Marine Science , Shandong University at Weihai , Weihai 264209 , People's Republic of China.

Two new p-terphenyls, strepantibins A and B (1 and 2), along with the first representative of a naturally occurring bisphenyltropone, strepantibin C (3), were characterized from a Streptomyces sp. associated with the larvae of the mud dauber wasp Sceliphron madraspatanum. Their structures were determined by high-resolution electrospray ionization mass spectrometry, NMR, and X-ray crystallography data interpretation. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b00821DOI Listing

Design of astaxanthin-loaded core-shell nanoparticles consisting of chitosan oligosaccharides and Poly lactic-co-glycolic acid: Enhancement of water-solubility, stability, and bioavailability.

J Agric Food Chem 2019 Apr 23. Epub 2019 Apr 23.

Astaxanthin, a hydrophobic carotenoid found in marine plants and animals, is claimed to exhibit various beneficial biological activities. Its use as a nutraceutical in foods, however, is currently limited by its low water-solubility and poor bioavailability. The goal of this paper was to fabricate astaxanthin-loaded colloidal particles to overcome these challenges. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06963DOI Listing

A Pyrene-Functionalized Metal-Organic Framework for Nonenzymatic and Ratiometric Detection of Uric Acid in Biological Fluid via Conformational Change.

Inorg Chem 2019 Apr 23. Epub 2019 Apr 23.

Department of Chemistry , Indian Institute of Technology Guwahati , Guwahati , 781039 , Assam , India.

In this work, a water-stable, pyrene-functionalized Hf-based mixed-ligand metal-organic framework (MOF) with UiO-66 (UiO = University of Oslo) framework topology was designed and synthesized for the fluorimetric detection of uric acid (UA) in aqueous medium. The free pyrene-functionalized ligand changes its conformation (monomer to excimer) upon framework formation, which was confirmed via fluorescence spectral studies. The MOF material showed a fast, selective, sensitive (detection limit 1. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03629DOI Listing

Pro-nifuroxazide Self-Assembly Leads to Triggerable Nanomedicine for Anti-Cancer Therapy.

ACS Appl Mater Interfaces 2019 Apr 23. Epub 2019 Apr 23.

Transcription factor STAT3 has been shown to regulate genes that are involved in stem cell self-renewal and thus represents a novel therapeutic target of great biological significance. However, many small molecule agents with potential effects in cancer therapy lack aqueous solubility and high off-target toxicity, hence impeding efficient bioavailability and activity. This work, for the first time, reports a prodrug-based strategy for selective and safer delivery of STAT3 inhibitors designed towards metastatic and drug resistant breast cancer. Read More

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http://pubs.acs.org/doi/10.1021/acsami.9b01343
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http://dx.doi.org/10.1021/acsami.9b01343DOI Listing
April 2019
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Assessment of Gill Pathological Responses in Yellowfin Sea Bream (Acanthopagrus Latus) Under Aeromonas Hydrophila Exposure.

Arch Razi Inst 2019 Mar 1;74(1):83-89. Epub 2019 Mar 1.

Department of Marine Biology, Faculty of Marine Science, Khorramshahr University of Marine Science and Technology, Khouzestan, Iran.

Bacterial diseases in cultured fish are considered the main problem with aquaculture system in Iran. The gills are multifunctional organs responsible for respiration, osmoregulation, nitrogenous waste excretion, and acid-base balance. Moreover, they are very sensitive to water contamination. Read More

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http://archrazi.areeo.ac.ir/article_118000.html
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http://dx.doi.org/10.22092/ari.2017.114702.1139DOI Listing

Modelling time-course relationships with multiple treatments: Model-Based Network Meta-Analysis for continuous summary outcomes.

Res Synth Methods 2019 Apr 23. Epub 2019 Apr 23.

Dept Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2PS, UK.

Background: Model-based meta-analysis (MBMA) is increasingly used to inform drug-development decisions by synthesising results from multiple studies to estimate treatment, dose-response and time-course characteristics. Network meta-analysis (NMA) is used in Health Technology Appraisals for simultaneously comparing effects of multiple treatments, to inform reimbursement decisions. Recently, a framework for dose-response model-based network meta-analysis (MBNMA) has been proposed that combines, often non-linear, MBMA modelling with the statistically robust properties of NMA. Read More

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http://dx.doi.org/10.1002/jrsm.1351DOI Listing

Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation towards Mycobacterium Tuberculosis and Plasmodium Falciparum.

Chemistry 2019 Apr 23. Epub 2019 Apr 23.

Saarland University, Organic Chemistry, Campus, Bldg. C4.2, 66123, Saarbrücken, GERMANY.

Cyclomarins are highly potent antimycobacterial and antiplasmodial cyclopeptides isolated from a marine bacterium (Streptomyces sp.). Previous studies have identified the target proteins and elucidated a novel mode of action, however there are currently only a few studies examining the structure-activity relationship (SAR) for both pathogens. Read More

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http://dx.doi.org/10.1002/chem.201901640DOI Listing
April 2019
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What is your diagnosis? Swab of an eyelid swelling from a tomato frog.

Vet Clin Pathol 2019 Apr 23. Epub 2019 Apr 23.

Department of Wildlife Health Sciences, National Zoological Park/Smithsonian Conservation Biology Institute, Washington, District of Columbia.

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http://dx.doi.org/10.1111/vcp.12737DOI Listing

Structural and functional characterization of β -glycoprotein I domain 1 in anti-melanoma cell migration.

Cancer Sci 2019 Apr 23. Epub 2019 Apr 23.

Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan.

We previously found that circulating β -glycoprotein I inhibits human endothelial cell migration, proliferation, and angiogenesis via diverse mechanisms. In the present study, we investigated the antitumor activities of β -glycoprotein I using structure-function analysis and mapped the critical region within the β -glycoprotein I peptide sequence that mediates anticancer effects. We constructed recombinant cDNA and purified different β -glycoprotein I polypeptide domains using a baculovirus expression system. Read More

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http://dx.doi.org/10.1111/cas.14030DOI Listing

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High-Fat Diet and Streptozotocin-Induced Type II Diabetes Nephropathy and Apoptosis.

J Food Sci 2019 Apr 23. Epub 2019 Apr 23.

Biomedical Sciences, School of Allied Health Sciences, Walailak Univ., Nakhon Si Thammarat, 80161, Thailand.

Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high-fat diet (5 g/day up to five weeks)-/streptozotocin (single ip, dose 30 mg/kgBW)-induced T2D nephropathy of albino mice. Read More

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http://dx.doi.org/10.1111/1750-3841.14511DOI Listing

Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia.

Background: Over 96% of high-grade ovarian carcinomas and 50% of all cancers are characterized by alterations in the p53 gene. Therapeutic strategies to restore and/or reactivate the p53 pathway have been challenging. By contrast, p63, which shares many of the downstream targets and functions of p53, is rarely mutated in cancer. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32053
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http://dx.doi.org/10.1002/cncr.32053DOI Listing
April 2019
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Fertility-related experiences after breast cancer diagnosis in the Sister and Two Sister Studies.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Commonly used chemotherapies can be toxic to the ovaries. To the authors' knowledge, the majority of studies evaluating receipt of fertility counseling for women in their reproductive years have been performed in specific settings, thereby limiting generalizability.

Methods: A nationwide sample of US women diagnosed with breast cancer before age 45 years completed a survey assessing the prevalence of fertility counseling. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32126
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http://dx.doi.org/10.1002/cncr.32126DOI Listing
April 2019
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