808 results match your criteria Biointerphases[Journal]


Grafted polymer brush coatings for growth of cow granulosa cells and oocyte-cumulus cell complexes.

Biointerphases 2020 May 22;15(3):031006. Epub 2020 May 22.

Smoluchowski Institute of Physics, Jagiellonian University, Łojasiewicza 11, 30-348 Kraków, Poland.

In the present work, three types of grafted brush coatings [P4VP, POEGMA246, and P(4VP-co-POEGMA246)] were successfully fabricated using graft polymerization of monomers "from the surface." The composition, thickness, and morphology of the grafted brush coatings were analyzed by TOF-SIMS, ellipsometry, and AFM, respectively. The chemical nature of the polymer surface plays a crucial role in the growth and development of the cow granulosa cells and, therefore, also oocyte-cumulus complexes. Read More

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http://dx.doi.org/10.1116/6.0000183DOI Listing

New insights into ToF-SIMS imaging in osteoporotic bone research.

Biointerphases 2020 May 21;15(3):031005. Epub 2020 May 21.

Institute of Physical Chemistry, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.

The present work focuses on the application of time-of-flight secondary ion mass spectrometry (ToF-SIMS) in osteoporotic bone research. In order to demonstrate the benefit, the authors present concrete application examples of ToF-SIMS in three different areas of bone research. ToF-SIMS as a mass spectrometric imaging technique allows simultaneous visualization of mineralized and nonmineralized bone tissue as well as implanted biomaterials and bone implant interphases. Read More

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http://dx.doi.org/10.1116/6.0000051DOI Listing

Lithium niobate nanoparticles as biofunctional interface material for inner ear devices.

Biointerphases 2020 May 20;15(3):031004. Epub 2020 May 20.

Department of Surgical, Medical, Molecular Pathology and Emergency Medicine, University of Pisa, Largo Lucio Lazzarino, 56126 Pisa, Italy.

Sensorineural hearing loss (SNHL) affects the inner ear compartment and can be caused by different factors. Usually, the lack, death, or malfunction of sensory cells deputed to transduction of mechanic-into-electric signals leads to SNHL. To date, the therapeutic option for patients impaired by severe or profound SNHL is the cochlear implant (CI), a high-tech electronic device replacing the entire cochlear function. Read More

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http://dx.doi.org/10.1116/6.0000067DOI Listing

Freezing from the inside: Ice nucleation in Escherichia coli and Escherichia coli ghosts by inner membrane bound ice nucleation protein InaZ.

Biointerphases 2020 May 19;15(3):031003. Epub 2020 May 19.

BIRD-C GmbH, Vienna 1030, Austria.

Ice nucleation (IN) active bacteria such as Pseudomonas syringae promote the growth of ice crystals more effectively than any material known. Using the specialized ice nucleation protein (INP) InaZ, P. syringae-the well studied epiphytic plant pathogen-attacks plants by frost damage and, likewise fascinating, drives ice nucleation within clouds when airborne in the atmosphere by linkage to the Earth's water cycle. Read More

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http://dx.doi.org/10.1116/1.5142174DOI Listing

Plasma enabled devices for the selective capture and photodynamic identification of prostate cancer cells.

Biointerphases 2020 May 15;15(3):031002. Epub 2020 May 15.

School of Engineering, University of South Australia, Mawson Lakes, Adelaide, SA 5095, Australia.

Prostate cancer is the second most common cancer in men and the second leading cause of male cancer deaths. The current blood test for detecting prostate cancers measures prostate-specific antigen. It has many limitations including a very high rate of false positives. Read More

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http://dx.doi.org/10.1116/6.0000047DOI Listing

Topographic cues reveal filopodia-mediated cell locomotion in 3D microenvironment.

Biointerphases 2020 May 4;15(3):031001. Epub 2020 May 4.

State Key Laboratory of New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.

In cell-material interactions, the formation and functioning of filopodia have been demonstrated to be very sensitive to topographic cues. However, substrate-exploring functions of filopodia in a 3D microenvironment remain elusive. In this study, the silk fibroin film with a micropillar structure was prepared to reveal a filopodial-mediated cell response to 3D topographic cues. Read More

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http://dx.doi.org/10.1116/1.5141051DOI Listing

Time-of-flight secondary ion mass spectrometry analysis of hair samples using unsupervised artificial neural network.

Biointerphases 2020 Apr 20;15(2):021013. Epub 2020 Apr 20.

Department of Materials and Life Science, Seikei University, 3-3-1, Kichijoji-Kitamachi, Musashino, Tokyo 180-8633, Japan.

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is extensively employed for the structural analysis of the outermost surfaces of organic materials, including biological materials, because it provides detailed compositional information and enables high-spatial-resolution chemical mapping. In this study, a combination of TOF-SIMS and data analysis was employed to evaluate biological materials composed of numerous proteins, including unknown ones. To interpret complicated TOF-SIMS data of human hair, an autoencoder, a dimensionality reduction method based on artificial neural networks, was applied. Read More

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http://dx.doi.org/10.1116/6.0000044DOI Listing

Investigations of the high-frequency dynamic properties of polymeric systems with quartz crystal resonators.

Biointerphases 2020 Apr 14;15(2):021012. Epub 2020 Apr 14.

Department of Materials Science and Engineering, Northwestern University, 2220 Campus Dr., Evanston, Illinois 60208-3108.

Opportunities arising from the use of the rheometric quartz crystal microbalance (RheoQCM) as a fixed frequency rheometer operating at 15 MHz are discussed. The technique requires the use of films in a specified thickness range that depends on the mechanical properties of the material of interest. A regime map quantifying the appropriate thicknesses is developed, based on the properties of a highly crosslinked epoxy sample that is representative of a broad class of polymeric materials. Read More

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http://dx.doi.org/10.1116/1.5142762DOI Listing

Ar-gas cluster ion beam in ToF-SIMS for peptide and protein analysis.

Biointerphases 2020 Apr 14;15(2):021011. Epub 2020 Apr 14.

Center for Nano-Bio Measurement, Korea Research Institute of Standards and Science (KRISS), Daejeon 34113, South Korea.

Since Ar-gas cluster ion beams (Ar-GCIBs) have been introduced into time-of-flight secondary ion mass spectrometry (ToF-SIMS), there have been various attempts to analyze organic materials and biomolecules that require low-damage analysis and high sensitivity, because Ar-GCIBs allow soft ionization of large molecules such as peptides and proteins due to the low energy per atom. Here, the authors adopted the Ar-GCIB as a primary beam to detect proteins including human insulin, ubiquitin, and cytochrome C (molecular weights are 5808, 8564, and 12 327 Da, respectively). They have confirmed that the detection of the intact proteins was possible when the Ar-GCIB was used as a primary ion beam. Read More

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http://dx.doi.org/10.1116/6.0000105DOI Listing

Evaluation of secondary ions related to plant tissue using least absolute shrinkage and selection operator.

Biointerphases 2020 Apr 9;15(2):021010. Epub 2020 Apr 9.

Faculty of Science and Technology, Seikei University, 3-3-1 Kichijoji-Kitamachi, Musashino-shi, Tokyo 180-8633, Japan.

With regard to life sciences, it is important to understand biological functions such as metabolic reactions at the cellular level. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) that can provide chemical mappings at 100 nm lateral resolutions is useful for obtaining three-dimensional maps of biological molecules in cells and tissues. TOF-SIMS spectra generally contain several hundred to several thousand secondary ion peaks that provide detailed chemical information. Read More

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http://dx.doi.org/10.1116/6.0000010DOI Listing

Modified silica nanoparticle coatings: Dual antifouling effects of self-assembled quaternary ammonium and zwitterionic silanes.

Biointerphases 2020 Apr 7;15(2):021009. Epub 2020 Apr 7.

ARC Research Hub for Australian Steel Manufacturing, Wollongong, NSW 2522, Australia.

This work examines the antifouling effect of quaternary ammonium silane (QAS) grafted from coatings of silica nanoparticles (SiNPs), independently and in combination with a zwitterionic sulfobetaine (SB) silane. The binding of QAS to the SiNP coatings was monitored using quartz crystal microgravimetry with dissipation monitoring (QCM-D) under varied pH and solution concentrations. Adsorption of bovine serum albumin protein was reduced on QAS modified SiNP coatings prepared under alkaline conditions due to the proposed generation of a pseudozwitterionic interface, where the underlying SiNP surface presents an anionic charge at high pH. Read More

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http://dx.doi.org/10.1116/1.5143141DOI Listing

Investigating matrix effects of different combinations of lipids and peptides on TOF-SIMS data.

Biointerphases 2020 04 2;15(2):021008. Epub 2020 Apr 2.

Faculty of Science and Technology, Seikei University, 3-3-1 Kichijoji-Kitamachi, Musashino-shi, Tokyo 180-8633, Japan.

Matrix effects, which cause a change in ion intensity, occur in mass spectrometry methods including time-of-flight secondary ion mass spectrometry (TOF-SIMS). Matrix effects often cause large issues in quantitative analysis because secondary ions related to a particular molecule could be dramatically enhanced or suppressed regardless of the concentration. To investigate matrix effects in biological samples, the authors evaluated mixed lipid {POPC [1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine, molecular weight (MW) 759. Read More

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http://dx.doi.org/10.1116/6.0000036DOI Listing

Human plasma protein adsorption to elastinlike polypeptide nanoparticles.

Biointerphases 2020 03 30;15(2):021007. Epub 2020 Mar 30.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.

Elastin-like polypeptides (ELPs) are being developed for numerous biomedical applications. There is a limited understanding of ELP biocompatibility, with conflicting results in the literature. Protein adsorption is the fate determining event for blood-contacting biomaterials. Read More

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http://dx.doi.org/10.1116/6.0000027DOI Listing

MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance.

Biointerphases 2020 03 26;15(2):021006. Epub 2020 Mar 26.

Department of Mechanical Engineering, The City College of the City University of New York, 160 Convent Ave., New York, New York 10031.

This paper presents the use of a commercial quartz crystal microbalance (QCM) to investigate live-cell activity in water-based toxic solutions. The QCM used in this research has a resonant frequency of 10 MHz and consists of an AT-cut quartz crystal with gold electrodes on both sides. This QCM was transformed into a functional biosensor by integrating with polydimethylsiloxane culturing chambers. Read More

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http://dx.doi.org/10.1116/1.5142722DOI Listing

Surface cleaning and sample carrier for complementary high-resolution imaging techniques.

Biointerphases 2020 03 25;15(2):021005. Epub 2020 Mar 25.

Department of Isotope Biogeochemistry, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.

Nowadays, high-resolution imaging techniques are extensively applied in a complementary way to gain insights into complex phenomena. For a truly complementary analytical approach, a common sample carrier is required that is suitable for the different preparation methods necessary for each analytical technique. This sample carrier should be capable of accommodating diverse analytes and maintaining their pristine composition and arrangement during deposition and preparation. Read More

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http://dx.doi.org/10.1116/1.5143203DOI Listing

Fast pH-mediated changes of the viscosity of protein solutions studied with a voltage-modulated quartz crystal microbalance.

Biointerphases 2020 03 24;15(2):021004. Epub 2020 Mar 24.

Institute of Physical Chemistry, Clausthal University of Technology, Arnold-Sommerfeld-Str. 4, D-38678 Clausthal-Zellerfeld, Germany.

An electrochemical quartz crystal microbalance is described, which achieves a time resolution down to 100 μs. Accumulation and averaging over a few hours bring the noise down to about 30 mHz. The application examples are pH-driven viscosity changes in albumin solutions. Read More

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http://dx.doi.org/10.1116/1.5140619DOI Listing

Electrochemical quartz crystal microbalance with dissipation investigation of fibronectin adsorption dynamics driven by electrical stimulation onto a conducting and partially biodegradable copolymer.

Biointerphases 2020 03 20;15(2):021003. Epub 2020 Mar 20.

Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, CP 26077, 05508-000 São Paulo, Brazil.

Functional surface coatings are a key option for biomedical applications, from polymeric supports for tissue engineering to smart matrices for controlled drug delivery. Therefore, the synthesis of new materials for biological applications and developments is promising. Hence, biocompatible and stimuli-responsive polymers are interesting materials, especially when they present conductive properties. Read More

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http://dx.doi.org/10.1116/1.5144983DOI Listing

Characterizing protein G B1 orientation and its effect on immunoglobulin G antibody binding using XPS, ToF-SIMS, and quartz crystal microbalance with dissipation monitoring.

Biointerphases 2020 03 13;15(2):021002. Epub 2020 Mar 13.

National ESCA and Surface Analysis Center for Biomedical Problems, Department of Chemical Engineering, University of Washington, Seattle, Washington 98195.

Controlling how proteins are immobilized (e.g., controlling their orientation and conformation) is essential for developing and optimizing the performance of in vitro protein-binding devices, such as enzyme-linked immunosorbent assays. Read More

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http://dx.doi.org/10.1116/1.5142560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069763PMC

Soft cluster-induced desorption/ionization mass spectrometry: How soft is soft?

Biointerphases 2020 03 12;15(2):021001. Epub 2020 Mar 12.

Institut für Angewandte Physik and Zentrum für Materialforschung, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 16, D-35392 Giessen, Germany.

Desorption/ionization induced by neutral clusters (DINeC) is used as an ultrasoft desorption/ionization method for the analysis of fragile biomolecules by means of mass spectrometry (MS). As a test molecule, the glycopeptide vancomycin was measured with DINeC-MS, and resulting mass spectra were compared to the results obtained with electrospray ionization (ESI), matrix assisted laser desorption ionization, and time-of-flight secondary ion MS. Of the desorption-based techniques, DINeC spectra show the lowest abundance of fragments comparable to ESI spectra. Read More

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http://dx.doi.org/10.1116/6.0000046DOI Listing

Analysis and refinement of 2D single-particle tracking experiments.

Biointerphases 2020 03 5;15(2):021201. Epub 2020 Mar 5.

Department of Chemistry and Biochemistry, Emmy-Noether Group "Bionanointerfaces," Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.

In recent decades, single particle tracking (SPT) has been developed into a sophisticated analytical approach involving complex instruments and data analysis schemes to extract information from time-resolved particle trajectories. Very often, mobility-related properties are extracted from these particle trajectories, as they often contain information about local interactions experienced by the particles while moving through the sample. This tutorial aims to provide a comprehensive overview about the accuracies that can be achieved when extracting mobility-related properties from 2D particle trajectories and how these accuracies depend on experimental parameters. Read More

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http://dx.doi.org/10.1116/1.5140087DOI Listing

Grafting of calcium chelating functionalities onto PLA monofilament fiber surfaces.

Biointerphases 2020 02 21;15(1):011006. Epub 2020 Feb 21.

Institute of Applied Physics, University of Bern, Sidlerstrasse 5, 3012 Bern, Switzerland.

Polymer surface grafting is widely used in the field of bone regeneration to increase calcium phosphate (CaP) adhesion, with the intent of improving mechanical properties of CaP-polymer composite cements. Reinforcement can be achieved using multiple combined functional groups and/or complex surface geometries that, however, concurrently influence multiple effects such as wetting, roughness, and interfacial strengthening. This study focused on the influence of a chelating group, namely aspartic acid, on the adsorption of divalent ions such as Ba or Ca onto poly-l-lactic acid (PLA) films. Read More

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http://dx.doi.org/10.1116/1.5129989DOI Listing
February 2020

In vitro evaluation of antimicrobial efficacy and durability of three copper surfaces used in healthcare.

Biointerphases 2020 02 10;15(1):011005. Epub 2020 Feb 10.

Department of Materials Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

Antimicrobial properties of solid copper (Cu) surfaces against various microorganisms have been demonstrated, but little is known about the durability and relative antimicrobial efficacy of different Cu formulations currently used in healthcare. The aim of this study was to assess whether three different formulations of copper-bearing alloys (integral, spray-on and Cu-impregnated surfaces) and a stainless steel control differed in their antimicrobial efficacy, durability, and compatibility with hospital-grade cleaner/disinfectants. The U. Read More

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http://dx.doi.org/10.1116/1.5134676DOI Listing
February 2020

Rapid detection of urokinase plasminogen activator using flexible paper-based graphene-gold platform.

Biointerphases 2020 02 4;15(1):011004. Epub 2020 Feb 4.

Department of Physics and Astronomy, Laboratory of Nano-Biophysics, Clemson Nanomaterials Institute, Clemson University, Clemson, South Carolina 29634.

Many studies have shown that urokinase plasminogen activator (uPA) is causally involved in promoting cancer invasion and metastasis. Thus, monitoring uPA levels could be very useful in cancer diagnosis, identification of initial metastasis, and guiding cancer treatment. Here, the authors developed a novel and scalable uPA sensor based on a graphene-gold nanoparticle platform that uses fluorescence of quantum dots to rapidly (<1 h) detect uPA up to 100 pM. Read More

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http://dx.doi.org/10.1116/1.5128889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064303PMC
February 2020

Polystyrene-block-polyethylene oxide thin films: In vitro cytocompatibility and protein adsorption testing.

Biointerphases 2020 01 31;15(1):011003. Epub 2020 Jan 31.

Department of Chemical and Materials Engineering, The University of Auckland, Auckland 1023, New Zealand.

Polystyrene-block-polyethylene oxide (PS-b-PEO) coated surfaces have been explored as cell culture substrates in the past decade. However, their cytocompatibility has not been extensively assessed. In this study, the in vitro cytocompatibility of PS-b-PEO was investigated. Read More

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http://dx.doi.org/10.1116/1.5135062DOI Listing
January 2020

Formation and characteristics of mixed lipid/polymer membranes on a crystalline surface-layer protein lattice.

Biointerphases 2020 01 16;15(1):011002. Epub 2020 Jan 16.

Department of NanoBiotechnology, Institute for Synthetic Bioarchitectures, University of Natural Resources and Life Sciences, Vienna, Muthgasse 11, 1190 Vienna, Austria.

The implementation of self-assembled biomolecules on solid materials, in particular, sensor and electrode surfaces, gains increasing importance for the design of stable functional platforms, bioinspired materials, and biosensors. The present study reports on the formation of a planar hybrid lipid/polymer membrane on a crystalline surface layer protein (SLP) lattice. The latter acts as a connecting layer linking the biomolecules to the inorganic base plate. Read More

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http://dx.doi.org/10.1116/1.5132390DOI Listing
January 2020

Carboxybetaine functionalized nanosilicas as protein resistant surface coatings.

Biointerphases 2020 01 6;15(1):011001. Epub 2020 Jan 6.

ARC Research Hub for Australian Steel Manufacturing, Wollongong, NSW 2522, Australia.

Materials with protein resistant properties are increasingly sought after for their potential application as low-fouling surface coatings. Hydrophilic coatings with improved resistance to protein fouling have been prepared from zwitterionic carboxybetaine (CB) functionalized silica nanoparticles (SiNPs). The authors report three methods of coating preparation via direct tethering of CB to predeposited particle films, a two-step surface functionalization process, and deposition of CB functionalized particle dispersions. Read More

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http://dx.doi.org/10.1063/1.5126467DOI Listing
January 2020

Hyaluronic acid-based hydrogels with independently tunable mechanical and bioactive signaling features.

Biointerphases 2020 01 2;14(6):061005. Epub 2020 Jan 2.

Department of Biomedical Engineering, Rutgers, The State University of New Jersey, 599 Taylor Road, Piscataway, New Jersey 08854.

Extracellular matrix provides critical signaling context to resident cells through mechanical and bioactive properties. To realize the potential of tissue engineering and regenerative medicine, biomaterials should allow for the independent control of these features. This study investigates a hydrogel system based on thiol-modified hyaluronic acid (HA-S) and polyethylene glycol diacrylate (PEGDA). Read More

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http://dx.doi.org/10.1063/1.5126493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008889PMC
January 2020

Early-stage corrosion, ion release, and the antibacterial effect of copper and cuprous oxide in physiological buffers: Phosphate-buffered saline vs Na-4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid.

Biointerphases 2019 12 12;14(6):061004. Epub 2019 Dec 12.

Functional Materials, Saarland University, 66123 Saarbruecken, Germany.

Copper surfaces are well known for their antibacterial effects due to the release of copper ions. This benefit has been shown in many antibacterial efficiency tests, however, without considering the corrosion behaviors of copper in the physiological solutions, which could play an indispensable role in ion release from the metallic surface. This study compared the ground copper surface and sputtered cuprous oxide (CuO) coating in two common physiological buffers: phosphate-buffered saline (PBS) and Na-4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (Na-HEPES). Read More

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http://dx.doi.org/10.1063/1.5123039DOI Listing
December 2019

Preparation and characterization of DNA array slides via surface Michael addition.

Biointerphases 2019 11 21;14(6):061003. Epub 2019 Nov 21.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning 116023, China.

The reliability and stability of array slides are a big concern for array vendors and end users. Herein, we report on a new type of array slide with high reactivity toward DNA probes and low side reaction. A one-step surface reaction via the Michael addition involved in preparing array slides was developed and characterized by x-ray photoelectron spectroscopy, contact angle, and fluorescence labeling. Read More

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http://dx.doi.org/10.1063/1.5124411DOI Listing
November 2019

Rapid evaluation of immobilized immunoglobulins using automated mass-segmented ToF-SIMS.

Biointerphases 2019 11 20;14(6):061002. Epub 2019 Nov 20.

Centre for Materials and Surface Science and Department of Chemistry and Physics, School of Molecular Sciences, La Trobe University, Melbourne, Victoria 3086, Australia.

Surface interactions largely control how biomaterials interact with biology and how many other types of materials function in industrial applications. ToF-SIMS analysis is extremely useful for interrogating the surfaces of complex materials and shows great promise in analyzing biological samples. Previously, the authors demonstrated that segmentation (between 1 and 0. Read More

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http://dx.doi.org/10.1063/1.5121450DOI Listing
November 2019

Biofunctionalized silk fibroin nanofibers for directional and long neurite outgrowth.

Biointerphases 2019 11 15;14(6):061001. Epub 2019 Nov 15.

State Key Laboratory of New Textile Materials and Advanced Processing Technology, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.

Engineered scaffolds simultaneously exhibiting multiple cues are highly desirable for neural tissue regeneration. Silk fibroin is a promising natural protein material for nerve repair. However, the lack of specific bioactive cues significantly hinders its application. Read More

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http://dx.doi.org/10.1063/1.5120738DOI Listing
November 2019

Comparison of the linking arm effect on the biological performance of a CD31 agonist directly grafted on L605 CoCr alloy by a plasma-based multistep strategy.

Biointerphases 2019 11 1;14(5):051009. Epub 2019 Nov 1.

Laboratory for Biomaterials and Bioengineering (CRC-I), Department of Min-Met-Mat Engineering and the CHU de Québec Research Center, Laval University, PLT-1745G, Québec G1V 0A6, Canada.

Stents are cardiovascular implants deployed on atherosclerotic arteries that aid in reopening, sustaining, and avoiding their collapse. Nevertheless, postimplantation complications exist, and the risk of the renewal of the plaque subsists. Therefore, enhanced properties are mandatory requirements for clinics. Read More

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http://dx.doi.org/10.1116/1.5120902DOI Listing
November 2019

Biological actions of Cu/Zn coimplanted TiN on Ti-6Al-4V alloy.

Biointerphases 2019 10 15;14(5):051008. Epub 2019 Oct 15.

College of Physics and Materials Science, Tianjin Normal University, Tianjin 300387, China.

Ti-6Al-4V alloy, as a widely used orthopedic and dental implant, has excellent biocompatibility and machinability. However, its poor corrosion resistance and antibacterial property may lead to tissue inflammation and postoperative infection, which hinders its further development. In this paper, to solve the above problems, copper (Cu) and zinc (Zn) ions were coimplanted into a titanium nitride (TiN) coated Ti-6Al-4V alloy via a plasma immersion ion implantation system (PIII). Read More

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http://dx.doi.org/10.1116/1.5116640DOI Listing
October 2019

Bioprospecting solid binding polypeptides for lithium ion battery cathode materials.

Biointerphases 2019 10 15;14(5):051007. Epub 2019 Oct 15.

Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250.

Biotemplating presents a promising approach to improve the performance of inorganic materials via specific control over morphology, crystal structure, and the size of particles during synthesis and assembly. Among other biotemplates, solid binding polypeptides (SBPs) isolated for the material of interest provide high binding affinity and selectivity due to distinct combinations of functional groups found in amino acids. Nanomaterials assembled and synthesized with SBPs have found widespread applications from drug delivery to catalysis and energy storage due to their improved properties. Read More

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http://dx.doi.org/10.1116/1.5111735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905653PMC
October 2019

Bioink formulations to ameliorate bioprinting-induced loss of cellular viability.

Biointerphases 2019 10 14;14(5):051006. Epub 2019 Oct 14.

Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711103, WB, India.

Extrusion bioprinting, the most affordable and convenient bioprinting modality, is also associated with high process-induced cell deaths. Mechanical stresses on the cells during pneumatic or piston extrusion generate excessive reactive oxygen species and activate apoptosis, inflammatory pathways in the cells. In this study, a bioink formulation is augmented with an antioxidant, N-acetyl cysteine (NAC) as a possible solution to abrogate the effect of bioprinting-associated cell survival losses. Read More

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http://dx.doi.org/10.1116/1.5111392DOI Listing
October 2019

Protein adsorption dynamics to polymer surfaces revisited-A multisystems approach.

Biointerphases 2019 10 2;14(5):051005. Epub 2019 Oct 2.

Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany.

Performance and safety of materials in contact with living matter are determined by sequential and competitive protein adsorption. However, cause and consequences of these processes remain hard to be generalized and predicted. In a new attempt to address that challenge, the authors compared and analyzed the protein adsorption and displacement on various thoroughly characterized polymer substrates using a combination of surface-sensitive techniques. Read More

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http://dx.doi.org/10.1116/1.5121249DOI Listing
October 2019

Peak selection matters in principal component analysis: A case study of syntrophic microbes.

Biointerphases 2019 09 25;14(5):051004. Epub 2019 Sep 25.

Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland, Washington 99354.

In situ liquid time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a powerful technique to study surface characterization of living biofilms in hydrated conditions. However, ToF-SIMS data analysis is still a great challenge in complicated bacterial biofilms, because many interference peaks from the medium may result in inaccurate interpretation. In this study, two syntrophic Geobacter populations are investigated using in situ liquid ToF-SIMS to reveal the biofilm surface changes between them due to direct interspecies electron transfer. Read More

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http://dx.doi.org/10.1116/1.5118237DOI Listing
September 2019

ToF-SIMS and TIRF microscopy investigation on the effects of HEMA copolymer surface chemistry on spatial localization, surface intensity, and release of fluorescently labeled keratinocyte growth factor.

Biointerphases 2019 09 23;14(5):051003. Epub 2019 Sep 23.

Department of Chemistry, University at Buffalo-State University of New York, Buffalo, New York 14221.

The need for direct biomaterial-based delivery of growth factors to wound surfaces to aid in wound healing emphasizes the importance of interfacial interactions between the biomaterial and the wound surface. These interactions include the spatial localization of growth factor, the surface intensity of growth factor in contact with the wound, and the release profile of growth factor to the wound surface. The authors report the use of time-of-flight secondary ion mass spectrometry to determine the relationship between biomaterial surface chemistry and the spatial localization of growth factor. Read More

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http://dx.doi.org/10.1116/1.5119871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905652PMC
September 2019
2 Reads

Layer-by-layer constructed hyaluronic acid/chitosan multilayers as antifouling and fouling-release coatings.

Biointerphases 2019 09 19;14(5):051002. Epub 2019 Sep 19.

Analytical Chemistry-Biointerfaces, Ruhr University Bochum, Bochum 44780, Germany.

Polyelectrolyte multilayers (PEMs) consisting of hyaluronic acid (HA) and chitosan (Ch) are extensively studied for biomedical applications and suppress bacterial and protein attachment. Here, we prepared and tested HA/Ch PEMs as marine fouling-release coatings. PEMs were constructed by layer-by-layer assembly using spin coating. Read More

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http://dx.doi.org/10.1116/1.5110887DOI Listing
September 2019

Improved ion imaging of slowly dried neurons and skin cells by graphene cover in time-of-flight secondary ion mass spectrometry.

Biointerphases 2019 09 17;14(5):051001. Epub 2019 Sep 17.

Department of New Biology and Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungang Daero, Hyeonpung-Eup, Dalseong-Gun, Daegu 42988, Republic of Korea.

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a powerful tool to obtain both chemical information and spatial distribution of specific molecules of interest on a specimen surface. However, since the focused ion beam requires ultrahigh vacuum conditions for desorption and ionization of analytes, proper specimen preparation, such as drying, freeze-drying, and frozen dehydration, is required for ToF-SIMS analysis. In particular, biological specimens with high moisture content generally have a problem of specimen deformation during the normal drying process for a vacuum environment. Read More

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http://dx.doi.org/10.1116/1.5118259DOI Listing
September 2019
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Highly-reactive haloester surface initiators for ARGET ATRP readily prepared by radio frequency glow discharge plasma.

Biointerphases 2019 08 22;14(4):041006. Epub 2019 Aug 22.

Department of Bioengineering, University of Washington, Seattle, Washington 98195.

New surface initiators for ARGET ATRP (activators regenerated by electron transfer atomic transfer radical polymerization) have been prepared by the plasma deposition of haloester monomers. Specifically, methyl 3-bromopropionate (M3BP), methyl 2-chloropropionate, and ethyl 2-fluoropropionate (E2FP) were plasma deposited onto glass discs using RF glow discharge plasma. This technique creates surface coatings that are resistant to delamination and rich in halogen species making them good candidates for surface initiators for ARGET ATRP. Read More

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http://dx.doi.org/10.1116/1.5110163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909822PMC

Combining the geometry of folded paper with liquid-infused polymer surfaces to concentrate and localize bacterial solutions.

Biointerphases 2019 08 20;14(4):041005. Epub 2019 Aug 20.

Department of Chemical and Biomedical Engineering, University of Maine, 5737 Jenness Hall, Orono, Maine 04469.

Point-of-care (POC) detection and diagnostic platforms provide critical information about health and safety conditions in austere and resource-limited settings in which medical, military, and disaster relief operations are conducted. In this work, low-cost paper materials commonly used in POC devices are coated with liquid-infused polymer surfaces and folded to produce geometries that precisely localize complex liquid samples undergoing concentration by evaporation. Liquid-infused polymer surfaces were fabricated by infusing silicone-coated paper with a chemically compatible polydimethylsiloxane oil to create a liquid overlayer. Read More

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http://dx.doi.org/10.1116/1.5114804DOI Listing

Titanium surface modifications and their soft-tissue interface on nonkeratinized soft tissues-A systematic review (Review).

Biointerphases 2019 08 16;14(4):040802. Epub 2019 Aug 16.

European Face Centre, Universitair Ziekenhuis Brussel, Vrije UniversiteitBrussel, 1090 Brussels, Belgium.

In this systematic review, the authors explored the surface aspects of various titanium (Ti) or Ti alloy medical implants, examining the interface formed between the implant and surrounding nonkeratinized soft tissues (periosteum, muscles, tendons, fat, cicatrix, or dura mater). A comprehensive search undertaken in July 2019 used strict keywords in relevant electronic databases to identify relevant studies. Based on the authors' inclusion criteria (restricted to in vivo studies), 19 of 651 publications qualified, all pertaining to animal models. Read More

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http://avs.scitation.org/doi/10.1116/1.5113607
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http://dx.doi.org/10.1116/1.5113607DOI Listing
August 2019
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Analysis of early cellular responses of anterior cruciate ligament fibroblasts seeded on different molecular weight polycaprolactone films functionalized by a bioactive poly(sodium styrene sulfonate) polymer.

Biointerphases 2019 08 12;14(4):041004. Epub 2019 Aug 12.

Laboratory of Biomaterials and Polymers of Specialty, Institut Galilée, Université Paris 13, Sorbonne Paris Cité, UMR CNRS 7244, 93430 Villetaneuse, France.

With the growing number of anterior cruciate ligament (ACL) ruptures and the increased interest for regenerative medicine procedures, many studies are now concentrated on developing bioactive and biodegradable synthetic ligaments. For this application, the choice of raw materials with appropriate physicochemical characteristics and long-term degradation features is essential. Polycaprolactone (PCL) has the advantage of slow degradation that depends on its molecular weight. Read More

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http://dx.doi.org/10.1116/1.5102150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909821PMC
August 2019
1 Read

Effect of TiO and Fe doped TiO nanoparticles on mitochondrial membrane potential in HBL-100 cells.

Biointerphases 2019 08 7;14(4):041003. Epub 2019 Aug 7.

School of Nanosciences, Central University of Gujarat, Gandhinagar 382030, India.

Titanium dioxide (TiO) nanoparticles (NPs) have made unbelievable progress in the field of nanotechnology and biomedical research. The proper toxicological assessment of TiO NPs and the reduction of its cytotoxicity need to be addressed. Fe doping in TiO has been investigated to reduce the toxic effects of TiO NPs. Read More

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http://dx.doi.org/10.1116/1.5097643DOI Listing

Predominant surface property of an anodized titanium that enhances the cell response.

Biointerphases 2019 07 29;14(4):041002. Epub 2019 Jul 29.

School of Earth, Energy and Environmental Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami, Hokkaido 090-8507, Japan.

The aim of this study is to evaluate the predominant material property that enhances the biocompatibility of an anodized titanium (Ti) implant. A Ti surface was anodized in an HPO electrolyte with various voltages. Then, the cell responses involving attachment, proliferation, and differentiation were evaluated. Read More

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http://dx.doi.org/10.1116/1.5108542DOI Listing

Atmospheric pressure mass spectrometric imaging of bio-tissue specimen using electrospray-assisted CW laser desorption and ionization source.

Biointerphases 2019 07 26;14(4):041001. Epub 2019 Jul 26.

Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungang Daero, Hyeonpung-Eup, Dalseong-Gun, Daegu 42988, Republic of Korea.

When a tissue slice pretreated with gold nanoparticles is irradiated with a focused 532-nm continuous wave laser, desorption is observed to be uniform and stable, and its shape is sharp and steep. However, since the desorbed molecules are still electrically neutral particles in atmospheric pressure (AP), additional procedure of ionizing them is necessary for AP mass spectrometry (AP-MS) analysis. Therefore, the authors have combined an electrospray device with a simple chamber connected to the airflow-assisted particle transport equipment mounted at the mass spectrometer inlet. Read More

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http://dx.doi.org/10.1116/1.5099563DOI Listing
July 2019
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Amyloid-like peptide nanofibrils as scaffolds for tissue engineering: Progress and challenges (Review).

Biointerphases 2019 07 8;14(4):040801. Epub 2019 Jul 8.

Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia.

Networks of amyloid-like nanofibrils assembled from short peptide sequences have the ability to form scaffolds that can encapsulate clinically relevant stem cells encouraging their attachment, growth, and differentiation into various lineages which can be used in tissue engineering applications to treat a range of diseases and traumas. In this review, the author highlights a selection of important proof-of-principle papers that show how this class of self-assembled networks is highly suited to biomaterial scaffold development. The author highlights recent studies which have shown that these scaffolds can be used to promote cell and tissue regeneration both in vitro and in vivo. Read More

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http://dx.doi.org/10.1116/1.5098332DOI Listing

Impacts of cross-linker chain length on the physical properties of polyampholyte hydrogels.

Biointerphases 2019 05 23;14(3):031002. Epub 2019 May 23.

Chemical and Materials Engineering, University of Idaho, 875 Perimeter Dr., Moscow, Idaho 83844.

Polymeric tissue engineering scaffolds have shown promise to aid in regeneration and repair of damaged tissue. In particular, nonfouling polymers have been proposed for eliminating biomaterial-induced concerns such as infection, scarring, and rejection by the immune system. Polyampholyte polymers are one class of nonfouling polymers that are composed of an equimolar mixture of positively and negatively charged monomer subunits. Read More

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http://avs.scitation.org/doi/10.1116/1.5097412
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http://dx.doi.org/10.1116/1.5097412DOI Listing
May 2019
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Calcium phosphate nanoparticles as intrinsic inorganic antimicrobials: In search of the key particle property.

Biointerphases 2019 05 20;14(3):031001. Epub 2019 May 20.

Advanced Materials and Nanobiotechnology Laboratory, Department of Biomedical and Pharmaceutical Sciences, Center for Targeted Drug Delivery, Chapman University, Irvine, California 92618-1908.

One of the main goals of materials science in the 21st century is the development of materials with rationally designed properties as substitutes for traditional pharmacotherapies. At the same time, there is a lack of understanding of the exact material properties that induce therapeutic effects in biological systems, which limits their rational optimization for the related medical applications. This study sets the foundation for a general approach for elucidating nanoparticle properties as determinants of antibacterial activity, with a particular focus on calcium phosphate nanoparticles. Read More

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http://dx.doi.org/10.1116/1.5090396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527436PMC
May 2019
3 Reads