756 results match your criteria Biointerphases[Journal]


Influence of chlorides and phosphates on the antiadhesive, antibacterial, and electrochemical properties of an electroplated copper-silver alloy.

Biointerphases 2019 04 9;14(2):021005. Epub 2019 Apr 9.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads bldg. 221, DK-2800 Kgs Lyngby, Denmark.

Antimicrobial surfaces such as copper alloys can reduce the spread of pathogenic microorganisms, e.g., in healthcare settings; however, the surface chemistry and thus the antibacterial activity are influenced by environmental parameters such as cleaning and disinfection procedures. Read More

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http://dx.doi.org/10.1116/1.5088936DOI Listing

Combined influence of nitric oxide and surface roughness in biofilm reduction across bacteria strains.

Biointerphases 2019 04 4;14(2):021004. Epub 2019 Apr 4.

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872.

Effective use of medical device implants is often hindered by infection, which may cause the device to be rejected from the body and seriously endanger health. Such infections are often a result of biofilm formation or microbial colonies collecting on a surface. Therefore, a challenge in the medical field is to mitigate the impact of biofilm formation in order to save thousands of lives and millions of healthcare dollars annually. Read More

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http://dx.doi.org/10.1116/1.5089246DOI Listing

Effect of monophasic pulsed stimulation on live single cell de-adhesion on conducting polymers with adsorbed fibronectin as revealed by single cell force spectroscopy.

Biointerphases 2019 03 29;14(2):021003. Epub 2019 Mar 29.

ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Wollongong, NSW 2522, Australia.

The force required to detach a single fibroblast cell in contact with the conducting polymer, polypyrrole doped with dodecylbenzene, was quantified using the Atomic Force Microscope-based technique, Single Cell Force Spectroscopy. The de-adhesion force for a single cell was 0.64 ± 0. Read More

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http://dx.doi.org/10.1116/1.5082204DOI Listing

Cytoskeletal synchronization of CHO cells with polymer functionalized fullerene C.

Biointerphases 2019 03 18;14(2):021002. Epub 2019 Mar 18.

Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum 695012, Kerala, India.

Recent developments in the field of fullerene C and its derivatives suggest its suitability in a wide range of applications ranging from photovoltaic instruments, development of solar based cells, cosmetics to enzyme inhibition treatment, and so on. These innovative applications raised possibilities of intentional or oblivious human-particle contact leading to possible deleterious effects on human health. The current study deals with the interaction of dextran functionalized fullerene C (Dex-C) on Chinese Hamster Ovary cells. Read More

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http://dx.doi.org/10.1116/1.5084002DOI Listing

Submicron polymeric particles accelerate insulin fibrillation by surface adsorption.

Biointerphases 2019 03 6;14(2):021001. Epub 2019 Mar 6.

Chemical and Biomolecular Engineering Department, Ohio University, Athens, Ohio 45701.

Insulin fibrillation is caused by the interaction of partially unfolded protein molecules resulting in the formation of insoluble aggregates. Engineered nano- and submicron particles have been reported to accelerate or inhibit the fibrillation of insulin. However, the mechanism by which engineered particles regulate insulin fibrillation kinetics is not fully understood. Read More

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http://dx.doi.org/10.1116/1.5083821DOI Listing
March 2019
2 Reads

Advances in materials for cellular applications (Review).

Biointerphases 2019 02 25;14(1):010801. Epub 2019 Feb 25.

Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708.

The goal of this review is to highlight materials that show exciting promise for either entirely new cellular-level applications or new approaches to long-standing biological challenges. The authors start with two more established materials, graphene and carbon nanotubes, and then progress to conducting polymers, followed by an overview of the microresonators, nanowires, and spasers used as intracellular lasers. These materials provide new approaches to gene and drug delivery, cellular regeneration, mechanical sensing, imaging, and the modulation and recording of cellular activity. Read More

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http://dx.doi.org/10.1116/1.5083803DOI Listing
February 2019

Alternating electric fields induce a period-dependent motion of Escherichia coli in three-dimension near a conductive surface.

Biointerphases 2019 02 20;14(1):011005. Epub 2019 Feb 20.

School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, People's Republic of China.

It has been demonstrated that electric fields can minimize surface adhesion of bacteria, but how they affect the near-surface bacterial dynamics has remained largely overlooked. In the present study, the three-dimensional motions of Escherichia coli (E. coli) HCB1 and HCB1414 near a conductive surface under alternating-current (AC) electric fields were monitored with digital holographic microscopy. Read More

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http://avs.scitation.org/doi/10.1116/1.5078543
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http://dx.doi.org/10.1116/1.5078543DOI Listing
February 2019
6 Reads

Effect of the nonspecific binding in differential impedance biosensing.

Biointerphases 2019 02 11;14(1):011004. Epub 2019 Feb 11.

Department of Physical Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.

The detection limits of impedance biosensors are dictated by the presence of background nonspecific binding, yet almost all the detection limits reported in the literature are determined using a clean buffer solution without confronting this real challenge. In this work, the authors employed the simplest "differential" impedance biosensor, composed of poly-l-lysine-polyethylene glycol-biotin-coated gold electrodes for the detection of streptavidin in the presence of 0.1% fetal calf serum, and studied the effect of the nonspecific binding on the performance of the differential impedance biosensing. Read More

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http://avs.scitation.org/doi/10.1116/1.5082717
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http://dx.doi.org/10.1116/1.5082717DOI Listing
February 2019
8 Reads

Direct immobilization of sugar probes on bovine serum albumin-coated gold substrate for the development of glycan biosensors.

Biointerphases 2019 02 6;14(1):011003. Epub 2019 Feb 6.

China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China.

Glycan biosensors based on surface plasmon resonance (SPR) spectroscopy have attracted a great deal of interest due to their potential applications in numerous biological and biomedical fields. Controlled immobilization of sugar probes on a gold substrate is believed to be critical for the performance of these SPR biosensors. In this regard, herein the authors report a direct coupling of mannose probes with bovine serum albumin (BSA) layer on the gold substrate via a squaric acid-mediated reaction under mild conditions, in which the BSA layer provides not only reactive amine groups but also a nonfouling surface property. Read More

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http://dx.doi.org/10.1116/1.5082005DOI Listing
February 2019

Replica moulded poly(dimethylsiloxane) microwell arrays induce localized endothelial cell immobilization for coculture with pancreatic islets.

Biointerphases 2019 01 30;14(1):011002. Epub 2019 Jan 30.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

PolyJet three-dimensional (3D) printing allows for the rapid manufacturing of 3D moulds for the fabrication of cross-linked poly(dimethylsiloxane) microwell arrays (PMAs). As this 3D printing technique has a resolution on the micrometer scale, the moulds exhibit a distinct surface roughness. In this study, the authors demonstrate by optical profilometry that the topography of the 3D printed moulds can be transferred to the PMAs and that this roughness induced cell adhesive properties to the material. Read More

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http://dx.doi.org/10.1116/1.5087737DOI Listing
January 2019

Loading the dice: The orientation of virus-like particles adsorbed on titanate assisted organosilanized surfaces.

Biointerphases 2019 01 28;14(1):011001. Epub 2019 Jan 28.

Departamento de Física Aplicada, Instituto de Ciencia de Materiales Nicolás Cabrera, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

The organization of virus-like particles (VLPs) on surfaces is a relevant matter for both fundamental and biomedical sciences. In this work, the authors have tailored surfaces with different surface tension components aiming at finding a relationship with the affinity of the different geometric/surface features of icosahedral P22 VLPs. The surfaces have been prepared by titanate assisted organosilanization with glycidyloxy, amino, and perfluoro silanes. Read More

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http://dx.doi.org/10.1116/1.5077010DOI Listing
January 2019
2 Reads

Length computation of irradiated plasmid DNA molecules.

Biointerphases 2018 12 31;13(6):061005. Epub 2018 Dec 31.

Department of Radiation Dosimetry, Nuclear Physics Institute of the CAS, Na Truhlarce 39/64, Praha 180 86, Czech Republic.

Compromised detection of short DNA fragments can result in underestimation of radiation-induced clustered DNA damage. The fragments can be detected with atomic force microscopy (AFM), followed by image analysis to compute the length of plasmid molecules. Plasmid molecules imaged with AFM are represented by open or closed curves, possibly with crossings. Read More

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http://dx.doi.org/10.1116/1.5050502DOI Listing
December 2018

Influence of multiscale and curved structures on the migration of stem cells.

Biointerphases 2018 12 31;13(6):06D408. Epub 2018 Dec 31.

CNRS, IS2M, UMR 7361, Université de Haute-Alsace, F-68100 Mulhouse, France.

Understanding how topographical cues can control cell behavior is a major fundamental question which is of particular interest for implant design. Recent findings show that cell-scale curvature, as well as nanoscale topography, can affect different aspects of cell migration. However, the correlation between specific curvature radii and cell behavior, as well as the combinatorial effect of nanoscale topography and cell-scale curvature, has not yet been investigated. Read More

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http://dx.doi.org/10.1116/1.5042747DOI Listing
December 2018

Copper distribution in breast cancer cells detected by time-of-flight secondary ion mass spectrometry with delayed extraction methodology.

Biointerphases 2018 12 20;13(6):06E412. Epub 2018 Dec 20.

Department of Biology and Biological Engineering, Chalmers University of Technology, Kemigården 4, 412 96 Gothenburg, Sweden.

Copper (Cu) is an essential transition metal ion that acts as a cofactor in many key enzymes. Cu is also needed for several hallmarks of cancer, and many copper-binding proteins are upregulated in various cancers. However, Cu-dependent cellular mechanisms and molecular pathways involved in cancer progression are not known. Read More

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http://dx.doi.org/10.1116/1.5053814DOI Listing
December 2018
1 Read

Structure-property relationships for wet dentin adhesive polymers.

Biointerphases 2018 12 17;13(6):061004. Epub 2018 Dec 17.

Department of Mechanical Engineering, Institute for Bioengineering Research, University of Kansas, 3111 Learned Hall, 1530 W 15th Street, Lawrence, Kansas 66045.

Dentin adhesive systems for composite tooth restorations are composed of hydrophilic/hydrophobic monomers, solvents, and photoinitiators. The adhesives undergo phase separation and concomitant compositional change during their application in the wet oral environment; phase separation compromises the quality of the hybrid layer in the adhesive/dentin interface. In this work, the adhesive composition in the hybrid layer can be represented using the phase boundaries of a ternary phase diagram for the hydrophobic monomer/hydrophilic monomer/water system. Read More

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http://avs.scitation.org/doi/10.1116/1.5058072
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http://dx.doi.org/10.1116/1.5058072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296910PMC
December 2018
8 Reads

Structure of von Willebrand factor A1 on polystyrene determined from experimental and calculated sum frequency generation spectra.

Biointerphases 2018 12 14;13(6):06E411. Epub 2018 Dec 14.

Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark.

The blood-clotting protein von Willebrand factor (vWF) can be activated by small molecules, high shear stress, and interactions with interfaces. It subsequently binds platelet receptor glycoprotein Ibα (GPIbα) at the surface of platelets, thereby playing a crucial role in blood clotting due to platelet activation, which is an important process to consider in the design of cardiovascular implants and biomaterials used in blood-contacting applications. The influence of surfaces on the activation and the molecular-level structure of surface-bound vWF is largely unknown. Read More

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http://dx.doi.org/10.1116/1.5056219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294649PMC
December 2018
1 Read

Biomedical surface analysis: Celebrating NESAC/Bio's 35th anniversary.

Authors:
David G Castner

Biointerphases 2018 12 12;13(6):06E101. Epub 2018 Dec 12.

National ESCA and Surface Analysis Center for Biomedical Problems, Department of Bioengineering and Department of Chemical Engineering, University of Washington, P.O. Box 351653, Seattle, Washington 98195.

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http://dx.doi.org/10.1116/1.5083140DOI Listing
December 2018

In Focus: Women in biointerface science.

Biointerphases 2018 12 7;13(6):06D101. Epub 2018 Dec 7.

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http://dx.doi.org/10.1116/1.5082176DOI Listing
December 2018

Multitechnique investigation into the aqueous behavior of plasma polymers.

Biointerphases 2018 12 5;13(6):06E410. Epub 2018 Dec 5.

ANFF-Vic Biointerface Engineering Hub, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia.

Plasma polymers are often used in applications requiring aqueous immersion; therefore, it is important to understand how this exposure affects the physical and chemical properties of the films. Three different plasma polymer films were deposited at different distances from the electrode, and the film properties were characterized using contact angle, ellipsometry, and x-ray photoelectron spectroscopy. The film behaviors in aqueous solutions were studied via quartz crystal microbalance with dissipation (QCM-D). Read More

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http://dx.doi.org/10.1116/1.5063750DOI Listing
December 2018
1 Read

Influence of surface topography on bacterial adhesion: A review (Review).

Biointerphases 2018 11 27;13(6):060801. Epub 2018 Nov 27.

Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.

Bacterial adhesion and biofilm formation are ubiquitous undesirable phenomena in the marine industry and the medical industry, usually causing economic losses and serious health problems. Numerous efforts have been made to reduce bacterial adhesion and subsequent biofilm formation, most of which are based on the release of toxic biocides from coatings or substrates. In recent years, surface topography has been found to substantially influence the interaction between bacteria and surfaces. Read More

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http://dx.doi.org/10.1116/1.5054057DOI Listing
November 2018

Surface-grafted antimicrobial drugs: Possible misinterpretation of mechanism of action.

Biointerphases 2018 11 27;13(6):06E409. Epub 2018 Nov 27.

Future Industries Institute, University of South Australia, Adelaide 5000, Australia.

Antimicrobial surface coatings that act through a contact-killing mechanism (not diffusive release) could offer many advantages to the design of medical device coatings that prevent microbial colonization and infections. However, as the authors show here, to prevent arriving at an incorrect conclusion about their mechanism of action, it is essential to employ thorough washing protocols validated by surface analytical data. Antimicrobial surface coatings were fabricated by covalently attaching polyene antifungal drugs to surface coatings. Read More

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http://avs.scitation.org/doi/10.1116/1.5050043
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http://dx.doi.org/10.1116/1.5050043DOI Listing
November 2018
18 Reads

Surface chemistry of the frog sticky-tongue mechanism.

Biointerphases 2018 11 26;13(6):06E408. Epub 2018 Nov 26.

The School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, Oregon 97331.

Frogs capture their prey with a highly specialized tongue. Recent studies indicate this tongue is covered with fibril-forming mucus that acts as a pressure sensitive adhesive. However, no analysis of the interfacial chemistry of frog tongue mucus has been performed. Read More

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http://dx.doi.org/10.1116/1.5052651DOI Listing
November 2018
1 Read

Progress in ligand design for monolayer-protected nanoparticles for nanobio interfaces.

Biointerphases 2018 11 21;13(6):06D502. Epub 2018 Nov 21.

Department of Materials Science and Engineering, North Carolina State University, 911 Partners Way, Engineering Building I, Raleigh, North Carolina 27695.

Ligand-functionalized inorganic nanoparticles, also known as monolayer-protected nanoparticles, offer great potential as vehicles for delivery of drugs, genes, and other therapeutics. These nanoparticles offer highly customizable chemistries independent of the size, shape, and functionality imparted by the inorganic core. Their success as drug delivery agents depends on their interaction with three major classes of biomolecules: nucleic acids, proteins, and membranes. Read More

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http://dx.doi.org/10.1116/1.5044381DOI Listing
November 2018
10 Reads

Enhanced uptake of plasmid at boronic acid decorated linear polyethylenimines results in higher transfection efficiency.

Biointerphases 2018 11 20;13(6):061003. Epub 2018 Nov 20.

Nucleic Acids Research Laboratory, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110 007, India.

High molecular weight polyethylenimines (PEIs) are considered as gold standard for transfection studies; however, cytotoxicity associated with branched ones and lower charge density on linear PEIs as well as lower uptake of the resulting deoxyribonucleic acid (DNA) complexes have limited their applications in clinical studies. In order to address these concerns and improve the uptake efficiency of the DNA complexes of linear polyethylenimine (25 kDa), the polymer was grafted with variable amounts of butylboronic acid to obtain a small series of linear polyethylenimine-butylboronic acid polymers. These modified polymers were allowed to interact with plasmid DNA and the resulting complexes were characterized by physicochemical techniques. Read More

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http://dx.doi.org/10.1116/1.5054930DOI Listing
November 2018
13 Reads

Robust and accurate measurements of gold nanoparticle concentrations using UV-visible spectrophotometry.

Biointerphases 2018 11 13;13(6):061002. Epub 2018 Nov 13.

National Physical Laboratory, Teddington TW11 0LW, United Kingdom.

This paper provides an empirical formula to calculate the extinction efficiencies of gold nanoparticles over the size range 1-1000 nm in fluids with refractive indexes which extend from  = 1 to  = 1.62. The formula contains a shape factor to account for nonspherical particles and aggregates. Read More

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http://dx.doi.org/10.1116/1.5054780DOI Listing
November 2018

Controllable functionalization of hydroxyl-terminated self-assembled monolayers catalytic oxa-Michael reaction.

Biointerphases 2018 11 8;13(6):06E407. Epub 2018 Nov 8.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.

Traditional strategies for the functionalization of materials displaying hydroxyl groups either require active esterification reagents or involve the nucleophilic attack of the hydroxyl group toward electrophilic groups. The former tends to hydrolyze in aqueous solutions while the latter occurs under harsh conditions. Herein, the authors reported a new method for the functionalization of hydroxyl groups on the surface catalytic oxa-Michael addition with vinyl sulfones. Read More

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http://avs.scitation.org/doi/10.1116/1.5052052
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http://dx.doi.org/10.1116/1.5052052DOI Listing
November 2018
10 Reads

Complex formation equilibria between cholesterol and diosgenin analogues in monolayers determined by the Langmuir method.

Biointerphases 2018 11 8;13(6):061001. Epub 2018 Nov 8.

Institute of Chemistry, University of Bialystok, K. Ciolkowskiego 1K, 15-245 Bialystok, Poland.

The purpose of this study was to investigate the interaction between diosgenin analogues [DioA: diosgenin acetate (DAc) and (25)-5α,6β-dihydroxyspirostan-3β-ol acetate (DSol)] and cholesterol (Ch) monolayers at the air/water interface. The surface tension of pure and mixed lipid monolayers at 22 °C was measured by using the Langmuir method with a Teflon trough and a Nima 9002 tensiometer. The surface tension values were used to calculate the π-A isotherms and to determine the molecular surface areas. Read More

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http://dx.doi.org/10.1116/1.5054064DOI Listing
November 2018

Differential orientation and conformation of surface-bound keratinocyte growth factor on (hydroxyethyl)methacrylate, (hydroxyethyl)methacrylate/methyl methacrylate, and (hydroxyethyl)methacrylate/methacrylic acid hydrogel copolymers.

Biointerphases 2018 10 25;13(6):06E406. Epub 2018 Oct 25.

Department of Chemistry, State University of New York at Buffalo, 475 Natural Sciences Complex, Buffalo, New York 14221.

The development of hydrogels for protein delivery requires protein-hydrogel interactions that cause minimal disruption of the protein's biological activity. Biological activity can be influenced by factors such as orientational accessibility for receptor binding and conformational changes, and these factors can be influenced by the hydrogel surface chemistry. (Hydroxyethyl)methacrylate (HEMA) hydrogels are of interest as drug delivery vehicles for keratinocyte growth factor (KGF) which is known to promote re-epithelialization in wound healing. Read More

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http://dx.doi.org/10.1116/1.5051655DOI Listing
October 2018
3 Reads

Facile synthesis of ultrasmall polydopamine-polyethylene glycol nanoparticles for cellular delivery.

Biointerphases 2018 10 25;13(6):06D407. Epub 2018 Oct 25.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.

Very small polydopamine (PDA) polyethylene glycol (PEG) crosslinked copolymer (PDA-PEG) nanoparticles have been prepared following a convenient one-step procedure in aqueous solution. Particle sizes and colloidal stabilities have been optimized by varying PEG in view of chain length and end group functionalities. In particular, amine-terminated PEG3000 [PEG(NH)] reacted with polydopamine intermediates so that very small, crosslinked PDA-PEG nanoparticles with sizes of less than 50 nm were formed. Read More

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http://dx.doi.org/10.1116/1.5042640DOI Listing
October 2018

Practical guide to characterize biomolecule adsorption on solid surfaces (Review).

Biointerphases 2018 10 23;13(6):06D303. Epub 2018 Oct 23.

CNRS UMR 5628 (LMGP), Grenoble 38016, France.

The control over the adsorption or grafting of biomolecules from a liquid to a solid interface is of fundamental importance in different fields, such as drug delivery, pharmaceutics, diagnostics, and tissue engineering. It is thus important to understand and characterize how biomolecules interact with surfaces and to quantitatively measure parameters such as adsorbed amount, kinetics of adsorption and desorption, conformation of the adsorbed biomolecules, orientation, and aggregation state. A better understanding of these interfacial phenomena will help optimize the engineering of biofunctional surfaces, preserving the activity of biomolecules and avoiding unwanted side effects. Read More

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http://avs.scitation.org/doi/10.1116/1.5045122
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http://dx.doi.org/10.1116/1.5045122DOI Listing
October 2018
25 Reads

adhered on surfaces: Resistance of a seawater bacterium against shear forces under the influence of roughness, surface energy, and zeta potential of the surfaces.

Biointerphases 2018 10 18;13(5):051003. Epub 2018 Oct 18.

Department of Physics and Research Center OPTIMAS, University of Kaiserslautern, Erwin Schrödinger-Straße 56, 67663 Kaiserslautern, Germany.

Bacteria in flowing media are exposed to shear forces exerted by the fluid. Before a biofilm can be formed, the bacteria have to attach to a solid surface and have to resist these shear forces. Here, the authors determined dislodgement forces of single bacteria by means of lateral force microscopy. Read More

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http://dx.doi.org/10.1116/1.5049226DOI Listing
October 2018
1 Read

Evaluation of the effectiveness of kINPen Med plasma jet and bioactive agent therapy in a rat model of wound healing.

Biointerphases 2018 10 16;13(5):051002. Epub 2018 Oct 16.

School of Mechanical and Materials Engineering, University College Dublin, Belfield, Dublin 4, Ireland.

Chronic nonhealing wounds, particularly those complicated by multidrug resistant infections, represent a major health and economic challenge. Plasma treatment promotes wound repair due to its antimicrobial, angiogenic, and cell modulating properties. This study investigated the efficacy of the kINPen Med system in promoting healing and assessed if efficacy was enhanced by adding collagen or hyaluronic acid (HA). Read More

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http://dx.doi.org/10.1116/1.5046489DOI Listing
October 2018
2 Reads

Minimal attachment of to DNA modified surfaces.

Biointerphases 2018 10 16;13(6):06E405. Epub 2018 Oct 16.

Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, Victoria, Australia.

Extracellular deoxyribonucleic acid (eDNA) exists in biological environments such as those around medical implants since prokaryotic or eukaryotic cells can undergo processes such as autolysis, necrosis, and apoptosis. For bacteria, eDNA has been shown to be involved in biofilm formation and gene transfer and acts as a nutrient source. In terms of biofilm formation, eDNA in solution has been shown to be very important in increasing attachment; however, very little is known about the role played by surface immobilized eDNA in initiating bacterial attachment and whether the nature of a DNA layer (physically adsorbed or covalently attached, and molecular weight) influences biofilm formation. Read More

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http://dx.doi.org/10.1116/1.5047453DOI Listing
October 2018

Challenges for the development of surface modified biodegradable polyester biomaterials: A chemistry perspective.

Biointerphases 2018 09 26;13(6):06D501. Epub 2018 Sep 26.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 Queensland, Australia.

The design of current implants produced from biodegradable polyesters is based on strength and rate of degradation and tailored by the choice of polyester used. However, detailed knowledge about the degradation mechanism of surface modified materials with applications in biomaterials science and tissue engineering is currently lacking. This perspective aims to outline the need for a greater focus on analyzing the degradation of modified polyesters to ensure they can fulfil their intended function and that degradation products can effectively be cleared from the body. Read More

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http://dx.doi.org/10.1116/1.5045857DOI Listing
September 2018

Perspectives on antibacterial performance of silver nanoparticle-loaded three-dimensional polymeric constructs.

Biointerphases 2018 09 27;13(6):06E404. Epub 2018 Sep 27.

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872.

Silver nanoparticle (AgNP)-loaded polymeric constructs are widely investigated for potential applications as drug delivery systems, wound dressings, and antibiofouling biomaterials. Herein, the authors present several methods for fabricating such materials and evaluate their efficacy against . HO plasma surface modification is employed to enhance material surface wettability (explored by water contact angle goniometry) and nanoparticle incorporation. Read More

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http://avs.scitation.org/doi/10.1116/1.5042426
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http://dx.doi.org/10.1116/1.5042426DOI Listing
September 2018
2 Reads

Controlling the surface structure of electrospun fibers: Effect on endothelial cells and blood coagulation.

Biointerphases 2018 09 24;13(5):051001. Epub 2018 Sep 24.

Empa, Swiss Federal Laboratories for Materials Science and Technology, Biointerfaces, 9014 St. Gallen, Switzerland.

The influence of nano- or micron-sized structures on polymer films as well as the impact of fiber diameter of electrospun membranes on endothelial cell (EC) and blood response has been studied for vascular tissue engineering applications. However, the influence of surface structures on micron-sized fibers on endothelial cells and blood interaction is currently not known. In this work, electrospun membranes with distinct fiber surface structures were designed to study their influence on the endothelial cell viability and thrombogenicity. Read More

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http://dx.doi.org/10.1116/1.5047668DOI Listing
September 2018
1 Read

Engineered systems to study the synergistic signaling between integrin-mediated mechanotransduction and growth factors (Review).

Biointerphases 2018 09 24;13(6):06D302. Epub 2018 Sep 24.

Department of Chemical and Materials Engineering, The University of Auckland, Auckland 1023, New Zealand.

While tremendous leaps in knowledge into cellular signaling and control have been achieved over the last few decades, there is still more to learn in how different signaling pathways act synergistically. A better understanding and control of cells and is important to enable more successful and safe applications of tissue engineering and stem cell therapy. This review is focused on two central ways cells sense their surroundings, namely, integrin-mediated mechanotransduction and growth factor signaling. Read More

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http://dx.doi.org/10.1116/1.5045231DOI Listing
September 2018

Nanostructured biomedical selenium at the biological interface (Review).

Biointerphases 2018 09 21;13(6):06D301. Epub 2018 Sep 21.

Center for Additive Manufacturing, RMIT University, Carlton, Victoria 3000, Australia.

This paper critically reviews the current evidence of research in biomedical applications of selenium nanoparticles (SeNPs) and their effects at cellular and tissue levels. In recent years, interest in SeNPs as a natural trace element nanomaterial for nanomedicine has resulted in a number of studies evaluating their bioactivities, such as anticancer, antimicrobial, and antioxidant properties. Significant data have been generated to demonstrate the effectiveness of SeNPs alone or in combination with other reagents. Read More

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http://dx.doi.org/10.1116/1.5042693DOI Listing
September 2018
9 Reads

Exploring the anomalous cytotoxicity of commercially-available poly(-isopropyl acrylamide) substrates.

Biointerphases 2018 09 19;13(6):06D406. Epub 2018 Sep 19.

Biomedical Engineering Graduate Program, University of New Mexico, Albuquerque, New Mexico 87131.

Poly(-isopropyl acrylamide) (pNIPAM) is a stimulus-responsive polymer that has been of great interest to the bioengineering community. When the temperature is lowered below its lower critical solution temperature (∼32 °C), pNIPAM rapidly hydrates, and adherent cells detach as intact cell sheets. This cell-releasing behavior in a physiologically relevant temperature range has led to NIPAM's use for engineered tissues and other devices. Read More

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http://dx.doi.org/10.1116/1.5045142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145861PMC
September 2018
19 Reads

Interactions of bioactive molecules with thin dendritic glycopolymer layers.

Biointerphases 2018 09 18;13(6):06D405. Epub 2018 Sep 18.

Department of Bioactive and Responsive Polymers, Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Strasse 6, 01069 Dresden, Germany.

The authors report on highly swellable, stable layers of spherical dendritic glycopolymers, composed of hyperbranched poly(ethylene imine) (PEI) as core and two different maltose shells (A = dense shell and B = open shell). These glycopolymers are cross-linked and attached with poly(ethylene--maleic anhydride) (PEMA) or citric acid on SiO substrates. The swelling and adsorption of biomolecules were analyzed by spectroscopic ellipsometry and quartz crystal microbalance with dissipation. Read More

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http://avs.scitation.org/doi/10.1116/1.5042703
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http://dx.doi.org/10.1116/1.5042703DOI Listing
September 2018
18 Reads

Carbon nanodots: Opportunities and limitations to study their biodistribution at the human lung epithelial tissue barrier.

Biointerphases 2018 09 11;13(6):06D404. Epub 2018 Sep 11.

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, CH-1700 Fribourg, Switzerland.

Inhalation of combustion-derived ultrafine particles (≤0.1 m) has been found to be associated with pulmonary and cardiovascular diseases. However, correlation of the physicochemical properties of carbon-based particles such as surface charge and agglomeration state with adverse health effects has not yet been established, mainly due to limitations related to the detection of carbon particles in biological environments. Read More

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http://dx.doi.org/10.1116/1.5043373DOI Listing
September 2018
1 Read

Nitric oxide-mediated fibrinogen deposition prevents platelet adhesion and activation.

Biointerphases 2018 09 7;13(6):06E403. Epub 2018 Sep 7.

School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado 80523.

Thrombosis is one of the most critical challenges faced by successful clinical use of blood-contacting medical devices. The formation of blood clots on medical device surfaces is a multistep process that includes protein adsorption, platelet adhesion and activation, and platelet aggregation, resulting in platelet consumption and blockage of blood flow. Without proper treatment, thrombosis will lead to ultimate device failure and create complications in patients. Read More

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http://dx.doi.org/10.1116/1.5042752DOI Listing
September 2018
2 Reads

Dealing with image shifting in 3D ToF-SIMS depth profiles.

Biointerphases 2018 09 5;13(6):06E402. Epub 2018 Sep 5.

NESAC/BIO, Department of Bioengineering, University of Washington, Seattle, Washington 98195.

The high sputter efficiency and low damage of gas cluster ion beams have enabled depth profiling to greater depths within organic samples using time-of-flight secondary ion mass spectrometry (ToF-SIMS). Due to the typically fixed geometry of the ion sources used in ToF-SIMS, as one digs into a surface, the position sampled by ion beams shifts laterally. This causes a lateral shift in the resulting images that can become quite significant when profiling down more than one micron. Read More

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http://dx.doi.org/10.1116/1.5041740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125139PMC
September 2018
1 Read

Effect of calcium ions on peptide adsorption at the aqueous rutile titania (110) interface.

Biointerphases 2018 08 31;13(6):06D403. Epub 2018 Aug 31.

Institute for Frontier Materials, Deakin University, Waurn Ponds, Victoria 3216, Australia.

How the presence of Ca2+ ions at the aqueous Read More

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http://dx.doi.org/10.1116/1.5046531DOI Listing
August 2018
5 Reads

Analysis of the Myc-induced pancreatic cell islet tumor microenvironment using imaging ToF-SIMS.

Biointerphases 2018 08 28;13(6):06D402. Epub 2018 Aug 28.

Department of Bioengineering, University of Washington, Seattle, Washington 98195.

Solid tumors are a structurally complex system, composed of many different cell types. The tumor microenvironment includes nonmalignant cell types that participate in complex interactions with tumor cells. The cross talk between tumor and normal cells is implicated in regulating cell growth, metastatic potential, and chemotherapeutic drug resistance. Read More

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http://dx.doi.org/10.1116/1.5038574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113053PMC
August 2018
1 Read

Potassium hydroxide treatment of UV-curable polysiloxane-type polymer for reproducible enhancement of cell adhesion and survival.

Biointerphases 2018 08 10;13(4):041009. Epub 2018 Aug 10.

International Laser Centre, Ilkovičova 3, Bratislava SK-841 04, Slovak Republic.

Polysiloxanes have shown exquisite properties for fabrication of microstructures for various biomedical and biotechnological applications. Nevertheless, their biocompatibility in terms of cell adhesion and survival ability is controversial. A simple polysiloxane modifying procedure that reproducibly enhances cell adhesion was proposed. Read More

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http://dx.doi.org/10.1116/1.5039933DOI Listing
August 2018
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Tunability of liquid-infused silicone materials for biointerfaces.

Biointerphases 2018 08 9;13(6):06D401. Epub 2018 Aug 9.

Wyss Institute for Biologically Inspired Engineering, 60 Oxford Street, Cambridge, Massachusetts 02138.

The ability to control the properties of bio-inspired liquid-infused surfaces is of interest in a wide range of applications. Liquid layers created using oil-infused polydimethylsiloxane elastomers offer a potentially simple way of accomplishing this goal through the adjustment of parameters such as curing agent ratio and oil viscosity. In this work, the effect of tuning these compositional parameters on the properties of the infused polymer are investigated, including infusion dynamics, stiffness, longevity in the face of continuous liquid overlayer removal, and resistance to bacterial adhesion. Read More

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http://dx.doi.org/10.1116/1.5039514DOI Listing
August 2018
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Transparent poly(3,4-ethylenedioxythiophene)-based microelectrodes for extracellular recording.

Biointerphases 2018 08 6;13(4):041008. Epub 2018 Aug 6.

BioMEMS-Lab, Department of Engineering, University of Applied Sciences, 63743 Aschaffenburg, Germany.

It is well known that at the interface between neuronal tissue and recording electrode low electrical impedance is required. However, if simultaneous optical detection or stimulation is an issue, good optical transmittance of the electrode material is desirable as well. State-of-the-art titanium nitride electrodes provide superior low impedance compared to gold or iridium, but are nontransparent. Read More

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http://dx.doi.org/10.1116/1.5041957DOI Listing

Bioinspired, nanoscale approaches in contemporary bioanalytics (Review).

Biointerphases 2018 07 26;13(4):040801. Epub 2018 Jul 26.

Department of Applied Physics, Chalmers University of Technology, Fysikgränd 3, Göteborg SE-412 96, Sweden.

The genesis for this topical review stems from the interdisciplinary Biointerfaces International conference 2016 (BI 2016) in Zurich, Switzerland, wherein the need for advances in analytical tools was both expressed and addressed. Pushing the limits of detection for characterizing individual components, such as single proteins, single drug-delivery vehicles, or probing single living cells in a more natural environment, will contribute to the understanding of the complex biomolecular systems central to a number of applications including medical diagnostics, tissue engineering, and drug screening and delivery. Accordingly, the authors begin with an overview of single nanoparticle analytics highlighting two emerging techniques and how they compare with existing techniques. Read More

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http://avs.scitation.org/doi/10.1116/1.5037582
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http://dx.doi.org/10.1116/1.5037582DOI Listing
July 2018
3 Reads