4,245 results match your criteria Bioinspired Biomimetic And Nanobiomaterials[Journal]


Bioinspired Adhesive and Antibacterial Microneedles for Versatile Transdermal Drug Delivery.

Research (Wash D C) 2020 8;2020:3672120. Epub 2020 May 8.

Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.

Microneedles have attracted increasing interest among various medical fields due to their painless, noninvasive, and efficient way of drug delivery. However, practical applications of these microneedles in different epidermal locations and environments are still restricted by their low adhesion and poor antimicrobial activity. Here, inspired by the antibacterial strategy of and adhesion mechanisms of mussel byssi and octopus tentacles, we develop hierarchical microneedles with multifunctional adhesive and antibacterial abilities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.34133/2020/3672120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231261PMC

Bioinspired 3D porous human placental derived extracellular matrix/silk fibroin sponges for accelerated bone regeneration.

Mater Sci Eng C Mater Biol Appl 2020 Aug 25;113:110990. Epub 2020 Apr 25.

Biomaterials and Tissue Engineering Laboratory, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. Electronic address:

Critical bone defects arising from traumatic injury and diseases are of major health concern since they are unable to heal spontaneously without clinical intervention. In this context, bone tissue engineering provides an attractive approach to treat bone defects by providing a bioactive template which has the potential to guide osseous tissue regeneration. In this study, porous hybrid placental extracellular matrix sponge (PIMS) was fabricated by a combinatorial method using silk fibroin (SF)/placental derived extracellular matrix and subsequently evaluated its efficacy towards bone tissue regeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2020.110990DOI Listing

Hybrid Unilamellar Vesicles of Phospholipids and Block Copolymers with Crystalline Domains.

Polymers (Basel) 2020 May 29;12(6). Epub 2020 May 29.

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Phospholipid (PL) membranes are ubiquitous in nature and their phase behavior has been extensively studied. Lipids assemble in a variety of structures and external stimuli can activate a quick switch between them. Amphiphilic block copolymers (BCPs) can self-organize in analogous structures but are mechanically more robust and transformations are considerably slower. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/polym12061232DOI Listing

Bioinspired phosphorylcholine containing polymer films with silver nanoparticles combining antifouling and antibacterial properties.

Biomater Sci 2013 May 14;1(5):470-477. Epub 2013 Jan 14.

Institute of Organic Chemistry III, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

The antibacterial (bioactive) and antifouling (biopassive) properties of stable, uniform, high surface coverage films of poly(hydroxyethyl methacrylate-co-2-methacryloyloxyethyl phosphorylcholine) (p(HEMA-co-MPC)) with embedded, non-leaching silver nanoparticles (AgNPs) are reported. Based on the experimental findings, a mechanism of action of AgNPs in antibacterial activity in combination with antifouling characteristics is discussed. Long-term antifouling studies of E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2bm00155aDOI Listing

Stabilizing viral nano-reactors for nerve-agent degradation.

Biomater Sci 2013 Aug 17;1(8):881-886. Epub 2013 Jun 17.

Department of Chemistry and Biochemistry, Center for BioInspired Nanomaterials, Montana State University, Bozeman, MT 59717, USA.

Virus like particles, and other naturally occurring protein containers, have emerged as excellent building blocks for nanomaterials design and synthesis. Here we exploit a directed assembly and encapsulation approach to sequester multiple copies of a phosphotriesterase (PTE) enzyme within the capsid of bacteriophage P22. Phosphotriesterase, from Brevundimonas diminuta, is an intriguing enzyme as it is highly active against a wide range of harmful insecticides and nerve agents such as Soman and Sarin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3bm60063gDOI Listing

Emerging Bioinspired Artificial Woods.

Adv Mater 2020 Jun 2:e2001086. Epub 2020 Jun 2.

Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, CAS Center for Excellence in Nanoscience, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, University of Science and Technology of China, Hefei, 230026, China.

As an abundant natural resource, wood has gained great attention for thousands of years, spanning from the primitive construction materials to the modern high-added-value engineering materials. The unique delicate microstructures and the wonderful properties (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.202001086DOI Listing

Synthesis and biological evaluation of a bioinspired, tissue-adhesive gellan gum-based hydrogel designed for minimally invasive delivery and retention of chondrogenic cells.

Biomater Sci 2020 Jun 2. Epub 2020 Jun 2.

Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ciência e Tecnologia Avepark, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal.

A dopamine-modified, bioinspired gellan gum hydrogel (STM-148B) with improved physicochemical and biological characteristics, suitable for minimally invasive cell delivery and retention in the context of cartilage repair, is herein presented. STM-148B's putative game-changing design characteristics include a highly biocompatible, animal-free and chemically defined composition, reproducibility of manufacture and ease of formulation. STM-148B undergoes rapid ionic crossinking by physiologically relevant mono and divalent cations to form stable 3D hydrogels that possess excellent tissue adhesiveness, such that additional fixation aids are rendered superfluous. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0bm00286kDOI Listing

Bioinspired kirigami metasurfaces as assistive shoe grips.

Nat Biomed Eng 2020 Jun 1. Epub 2020 Jun 1.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Falls and subsequent complications are major contributors to morbidity and mortality, especially in older adults. Here, by taking inspiration from claws and scales found in nature, we show that buckling kirigami structures applied to footwear outsoles generate higher friction forces in the forefoot and transversally to the direction of movement. We identified optimal kirigami designs capable of modulating friction for a range of surfaces, including ice, by evaluating the performance of the dynamic kirigami outsoles through numerical simulations and in vitro friction testing, as well as via human-gait force-plate measurements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41551-020-0564-3DOI Listing

Bioinspired nanofibrils-humped Fibers with Strong Capillary for Fog Capture.

ACS Appl Mater Interfaces 2020 Jun 1. Epub 2020 Jun 1.

Bio-inspired nanofibrils-humped fibers (BNFs) are fabricated by using thermoplastic polyester ester elastomer (TPEE) and chitosan (CS), via combining the electrospinning technique and the fluid coating method to achieve periodic humps composed of random interlaced nanofibrils and joint composed of aligned nanofibrils, which are highly similar to the micro-/nanostructures of wetted spider silk. Especially, nanofibrils can raise the specific area of hump to capture the fog droplet effectively and transport water in channels between nanofibrils in humid conditions, and thus the fog droplets can coalesce and be high-efficiently transported into humps for water collection directionally. Such an ability of high efficient water collection is attributed to an effect of inside transportation on the outer shell of BNF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c06945DOI Listing

Antibacterial, anticoagulant and cytotoxic evaluation of biocompatible nanocomposite of chitosan loaded green synthesized bioinspired silver nanoparticles.

Int J Biol Macromol 2020 May 26. Epub 2020 May 26.

Food and Feed Safety Laboratory, Food and Marine Resources Research Centre, PCSIR Laboratories Complex, Shahrah-e-Salimuzzaman Siddiqui, Off University Road, 75280, Karachi, Sindh 74200, Pakistan.

Present work reports the green synthesis of chitosan functionalized silver nanoparticles (CS-AgNPs) using ethanolic buds extract of Sygyzium aromaticum. CS-AgNPs were characterized physically, evaluated for antibacterial, anticoagulant and antiplatelet activities, and toxicity profile. The physical characterization of CS-AgNPs was done by UV/vis, SEM, TEM, FTIR and EDX. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.05.197DOI Listing

Remodeling of Aligned Fibrous Extracellular Matrix by Encapsulated Cells under Mechanical Stretching.

Acta Biomater 2020 May 26. Epub 2020 May 26.

Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P.R. China; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P.R. China. Electronic address:

Extracellular matrix (ECM) remodeling is essential for the development and functions of connective tissues (e.g., heart, muscle and the periodontal ligament), and entails the highly anisotropic response of cells and their organized ECM molecules to mechanical stimulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2020.05.027DOI Listing
May 2020
6.025 Impact Factor

Artificial Platelets for Efficient siRNA Delivery to Clear "Bad Cholesterol".

ACS Appl Mater Interfaces 2020 May 29. Epub 2020 May 29.

Low density lipoprotein cholesterol (LDL-C) is usually considered as a "bad cholesterol", for it is one of the major risk factors for coronary heart disease. As a scavenger of LDL-C, the low density lipoprotein receptor (LDLR) binds with LDL-C in the liver. However, the protein levels and function of LDLR are regulated by Proprotein convertase subtilisin/kexin type 9 (PCSK9). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c07559DOI Listing

Anisotropy links cell shapes to tissue flow during convergent extension.

Proc Natl Acad Sci U S A 2020 May 28. Epub 2020 May 28.

Department of Mechanical Engineering, Columbia University, New York, NY 10027;

Within developing embryos, tissues flow and reorganize dramatically on timescales as short as minutes. This includes epithelial tissues, which often narrow and elongate in convergent extension movements due to anisotropies in external forces or in internal cell-generated forces. However, the mechanisms that allow or prevent tissue reorganization, especially in the presence of strongly anisotropic forces, remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1916418117DOI Listing

Copper catalysis with redox-active ligands.

Beilstein J Org Chem 2020 24;16:858-870. Epub 2020 Apr 24.

Université de Strasbourg, Institut de Chimie, UMR CNRS 7177, 67000 Strasbourg, France.

Copper catalysis finds applications in various synthetic fields by utilizing the ability of copper to sustain mono- and bielectronic elementary steps. Further to the development of well-defined copper complexes with classical ligands such as phosphines and N-heterocyclic carbenes, a new and fast-expanding area of research is exploring the possibility of a complementing metal-centered reactivity with electronic participation by the coordination sphere. To achieve this electronic flexibility, redox-active ligands can be used to engage in a fruitful "electronic dialogue" with the metal center, and provide additional venues for electron transfer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3762/bjoc.16.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214867PMC

Exploiting the intrinsic deformation of a prosthetic foot to estimate the center of pressure and ground reaction force.

Bioinspir Biomim 2020 May 27. Epub 2020 May 27.

The Robotics Research Lab, University of Kaiserslautern, Postbox 3049, Kaiserslautern, 67653, GERMANY.

The properties of the foot deployed in a bipedal robot that targets the rendering of a human-like dynamic gait are crucial. Firstly, it has to implement a set of mechanical mechanisms/properties that improve the efficiency of the locomotion. Secondly, it has to integrate a sensory system that captures the interaction with the ground with suitable precision. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1748-3190/ab96d7DOI Listing

Microtubule Cytoskeleton Remodeling by Nanosecond Pulsed Electric Fields.

Adv Biosyst 2020 May 27:e2000070. Epub 2020 May 27.

Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, Prague, 142 20, Czechia.

Remodeling of nanoscopic structures is not just crucial for cell biology, but it is also at the core of bioinspired materials. While the microtubule cytoskeleton in cells undergoes fast adaptation, adaptive materials still face this remodeling challenge. Moreover, the guided reorganization of the microtubule network and the correction of its abnormalities is still a major aim. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adbi.202000070DOI Listing

Water-Soluble Polymers with Appending Porphyrins as Bioinspired Catalysts for the Hydrogen Evolution Reaction.

Angew Chem Int Ed Engl 2020 May 26. Epub 2020 May 26.

Renmin University of China, Department of Chemistry, 59 Zhongguancun Street, 100872, Beijing, CHINA.

Molecular design to improve catalyst performance is significant but challenging. In enzymes, residue groups that are close to reaction centers play critical roles in regulating activities. Using this bioinspired strategy, we designed three water-soluble polymers with appending Co porphyrins and different side-chain groups to mimic enzyme reaction centers and activity-controlling residue groups, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202003836DOI Listing

In Vivo Disintegration and Bioresorption of a Nacre-Inspired Graphene-Silk Film Caused by the Foreign-Body Reaction.

iScience 2020 May 13;23(6):101155. Epub 2020 May 13.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China; Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, Beijing 100176, China. Electronic address:

Graphene-based substrates are emerging as a promising functional platform for biomedical applications. Although dispersible graphene sheets have been demonstrated to be biodegradable, their assembled macroscopic architectures are biopersistent because of strong π-π interactions. In this study, we developed a nacre-inspired graphene-silk nanocomposite film by vacuum filtration with a subsequent green chemical reduction procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2020.101155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251954PMC

Biomimetic and Bioinspired Silicifications: Recent Advances for Biomaterial Design and Applications.

Acta Biomater 2020 May 21. Epub 2020 May 21.

Department of Biotechnology and Bioinformatics, Korea University, Sejong-Ro 2511, Sejong, 30019, Republic of Korea. Electronic address:

The rational design and controllable synthesis of functional silica-based materials have gained increased interest in a variety of biomedical and biotechnological applications due to their unique properties. The current review shows that marine organisms, such as siliceous sponges and diatoms, could be the inspiration for the fabrication of advanced biohybrid materials. Several biomolecules were involved in the molecular mechanism of biosilicification in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2020.05.017DOI Listing

Antioxidant Properties of Agri-food Byproducts |and Specific Boosting Effects of Hydrolytic Treatments.

Antioxidants (Basel) 2020 May 18;9(5). Epub 2020 May 18.

Department of Chemical Sciences, University of Naples "Federico II", Via Cintia 4, I-80126 Naples, Italy.

Largely produced agri-food byproducts represent a sustainable and easily available source of phenolic compounds, such as lignins and tannins, endowed with potent antioxidant properties. We report herein the characterization of the antioxidant properties of nine plant-derived byproducts. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing/antioxidant power (FRAP) assays indicated the superior activity of pomegranate peels and seeds, grape pomace and pecan nut shell. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antiox9050438DOI Listing

Ultrarobust TiCT MXene-Based Soft Actuators Bamboo-Inspired Mesoscale Assembly of Hybrid Nanostructures.

ACS Nano 2020 May 28. Epub 2020 May 28.

State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China.

Soft actuation materials are highly desirable in flexible electronics, soft robotics, . However, traditional bilayered actuators usually suffer from poor mechanical properties as well as deteriorated performance reliability. Here, inspired by the delicate architecture of natural bamboo, we present a hierarchical gradient structured soft actuator mesoscale assembly of micro-nano-scaled two-dimentional MXenes and one-dimentional cellulose nanofibers with molecular-scaled strong hydrogen bonding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.0c01779DOI Listing

Long-acting microneedles: a progress report of the state-of-the-art techniques.

Drug Discov Today 2020 May 18. Epub 2020 May 18.

Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China; Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address:

Microneedles (MNs) are a self-administrable and painless alternative to hypodermic needles for bolus drug delivery. Sustained drug release is the preferable drug delivery method because it reduces the chemical burden in patients and can deliver therapeutics that require long-term exposure. Here, we review recent advances in long-acting MNs, summarizing polymers used to fabricate long-acting MNs and mechanisms controlling drug release. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2020.05.006DOI Listing

Self-Healing Properties of Bioinspired Amorphous CaCO/Polyphosphate-Supplemented Cement.

Molecules 2020 May 19;25(10). Epub 2020 May 19.

ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.

There is a strong interest in cement additives that are able to prevent or mitigate the adverse effects of cracks in concrete that cause corrosion of the reinforcement. Inorganic polyphosphate (polyP), a natural polymer that is synthesized by bacteria, even those on cement/concrete, can increase the resistance of concrete to progressive damage from micro-cracking. Here we use a novel bioinspired strategy based on polyP-stabilized amorphous calcium carbonate (ACC) to give this material self-healing properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules25102360DOI Listing
May 2020
2.416 Impact Factor

Bioinspired Soft Microrobots with Precise Magneto-Collective Control for Microvascular Thrombolysis.

Adv Mater 2020 May 20:e2000366. Epub 2020 May 20.

School of Electronics and Information Engineering, Tongji University, 4800 Caoan Road, Shanghai, 201804, China.

New-era soft microrobots for biomedical applications need to mimic the essential structures and collective functions of creatures from nature. Biocompatible interfaces, intelligent functionalities, and precise locomotion control in a collective manner are the key parameters to design soft microrobots for the complex bio-environment. In this work, a biomimetic magnetic microrobot (BMM) inspired by magnetotactic bacteria (MTB) with speedy motion response and accurate positioning is developed for targeted thrombolysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.202000366DOI Listing

pH Tuning of Water-Soluble Arylazopyrazole Photoswitches.

Chemistry 2020 May 19. Epub 2020 May 19.

Albert-Ludwigs-University of Freiburg, Institut für Makromolekulare Chemie, Stefan-Meier-Str. 31, 79104, Freiburg, GERMANY.

Arylazopyrazoles are an emerging class of photoswitches with red-shifted switching wavelength, high photostationary state, long thermal half-lives and facile synthetic access. Understanding pathways for a simple modulation of the thermal half-lives, while keeping other parameters of interest constant, is an important aspect for out-of-equilibrium systems design and application. Here, we demonstrate that the thermal half-life of a water-soluble, PEG-tethered arylazo-bis(o-methylated)pyrazole (AAP) can be tuned by more than five orders of magnitude using simple pH adjustment, which is beyond the tunability of azobenzenes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.202000659DOI Listing

Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration.

Bioconjug Chem 2020 Jun 3. Epub 2020 Jun 3.

Analytical & Testing Center, Sichuan University, Chengdu 610065, China.

Bioinspired by the morphology of osteoclast-resorbed bone surfaces, we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which consists of a nanofibrous network, on titanium (Ti) substrate via a simple two-step hydrothermal method, trying to mimic natural bone compositionally and microstructurally. The studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared , the significantly improved new bone formation in the early stage and the much stronger interfacial bonding with the surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified Ti implants hold great potential for orthopedic and dental applications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.bioconjchem.0c00201DOI Listing

Bioinspired design of a robust -methylating agent.

Sci Adv 2020 May 8;6(19):eaba0946. Epub 2020 May 8.

State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.

Methods to incorporate deuterium atoms into organic molecules are valuable for the pharmaceutical industry. The introduction of deuterium atoms by a synthetic method enables the direct tracing of the drug molecule without substantially altering its structure or function. The methyl group is one of the most commonly occurring carbon fragments in biologically active molecules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aba0946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209982PMC

Chemomechanical origin of directed locomotion driven by internal chemical signals.

Sci Adv 2020 May 1;6(18):eaaz9125. Epub 2020 May 1.

Department of Chemistry and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA.

Asymmetry in the interaction between an individual and its environment is generally considered essential for the directional properties of active matter, but can directional locomotions and their transitions be generated only from intrinsic chemical dynamics and its modulation? Here, we examine this question by simulating the locomotion of a bioinspired active gel in a homogeneous environment. We find that autonomous directional locomotion emerges in the absence of asymmetric interaction with the environment and that a transition between modes of gel locomotion can be induced by adjusting the spatially uniform intensity of illumination or certain kinetic and mechanical system parameters. The internal wave dynamics and its structural modulation act as the impetus for signal-driven active locomotion in a manner similar to the way in which an animal's locomotion is generated via driving by nerve pulses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aaz9125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195122PMC

Flexible Piezoresistive Sensors with Wide-Range Pressure Measurements Based on a Graded Nest-like Architecture.

ACS Appl Mater Interfaces 2020 Jun 1. Epub 2020 Jun 1.

Center for Stretchable Electronics and Nano Sensors (SENS), Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China.

Flexible pressure sensors present great potential in the application of human health monitoring, tactile function of prosthesis, and electronic skin for robotics. These applications require different trade-off between the sensitivity and sensing range, therefore, it is imperative to develop range-specific sensitivities in a single sensor. In this paper, a bioinspired strategy for a resistive pressure sensor using a graded porous material is proposed to measure pressures from several pascals to megapascals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c03326DOI Listing

The impact of biosensing in a pandemic outbreak: COVID-19.

Biosens Bioelectron 2020 May 6;163:112274. Epub 2020 May 6.

Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT), University of Freiburg, Georges-Koehler-Allee 105, Freiburg, 79110, Germany; Department of Microsystems Engineering (IMTEK), Laboratory for Sensors, University of Freiburg, Georges-Koehler-Allee 103, Freiburg, 79110, Germany. Electronic address:

COVID-19 pandemic outbreak is the most astounding scene ever experienced in the XXI century. In this opinionated review, we underscore the crucial role of biosensing to handle with such situations. As a matter of fact, testing accelerates life-saving decisions on treatment and isolation of COVID-19 patients in an early stage, and thereby, decelerating or even preventing the spread of such emerging infectious diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bios.2020.112274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202811PMC

Picoliter agar droplet breakup in microfluidics meets microbiology application: numerical and experimental approaches.

Lab Chip 2020 May 18. Epub 2020 May 18.

Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta T2N 1N4, Canada. and BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta T2N 1N4, Canada and Centre for Bioengineering Research and Education, University of Calgary, Calgary, Alberta T2N 1N4, Canada.

Droplet microfluidics has provided lab-on-a-chip platforms with the capability of bacteria encapsulation in biomaterials, controlled culture environments, and live monitoring of growth and proliferation. The droplets are mainly generated from biomaterials with temperature dependent gelation behavior which necessitates stable and size-controlled droplet formation within microfluidics. Here, the biomaterial is agar hydrogel with a non-Newtonian response at operating temperatures below 40 °C, the upper-temperature threshold for cells and pathogens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0lc00300jDOI Listing

Bioinspired Hydrophobic Cellulose Nanocrystal Composite Films as Organic-Solvent-Responsive Structural-Color Rewritable Papers.

ACS Appl Mater Interfaces 2020 May 28. Epub 2020 May 28.

School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

Lots of beetles, moths, and birds in the natural world present stunning unique structural colors as well as excellent hydrophobic performances. Herein, a novel bioinspired variable structural-color film with organic-solvent responsiveness and surface hydrophobicity was fabricated. Cellulose nanocrystals (CNCs) provided structural color with left-handed helicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c04785DOI Listing

Constructing Cross-Linked Nanofibrous Scaffold via Dual-Enzyme-Instructed Hierarchical Assembly.

Langmuir 2020 Jun 1. Epub 2020 Jun 1.

Bioinspired Soft Matter Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna Son, Okinawa 904-0495, Japan.

To explore the potential of step-by-step assembly in the fabrication of biological materials, we designed and synthesized two peptide-based molecules for enzyme-instructed hierarchical assembly. Upon the treatment of alkaline phosphatase, one molecule undergoes enzyme-instructed self-assembly forming uniformed nanofibers. The other one that can self-assemble into vesicles undergoes enzyme-induced transformation of self-assembly converting vesicles into irregular aggregates upon the treatment of carboxylesterase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.langmuir.0c01023DOI Listing

Self-assembly of multi-scale anisotropic hydrogels through interfacial polyionic complexation.

J Biomed Mater Res A 2020 May 17. Epub 2020 May 17.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA.

Polysaccharides are explored for various tissue engineering applications due to their inherent cytocompatibility and ability to form bulk hydrogels. However, bulk hydrogels offer poor control over their microarchitecture and multi-scale hierarchy, parameters important to recreate extracellular matrix-mimetic microenvironment. Here, we developed a versatile platform technology to self-assemble oppositely charged polysaccharides into multi-scale fibrous hydrogels with controlled anisotropic microarchitecture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.37001DOI Listing

Design of tree-frog-inspired adhesives.

Integr Comp Biol 2020 May 15. Epub 2020 May 15.

Experimental Zoology Group, Wageningen University & Research, De Elst 1, 6708 WD Wageningen, The Netherlands.

The adhesive toe pads of tree frogs have inspired the design of various so-called 'smooth' synthetic adhesives for wet environments. However, these adhesives do not reach the attachment performance of their biological model in terms of contact formation, maintenance of attachment, and detachment. In tree frogs, attachment is facilitated by an interconnected ensemble of superficial and internal morphological components, which together form a functional unit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/icb/icaa037DOI Listing

Liquid Plasticine Integrated with Isoelectric Focusing for Miniaturized Protein Analysis.

Anal Chem 2020 May 27. Epub 2020 May 27.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China.

Developing miniaturized and rapid protein analytical platforms is urgently needed for on-site protein analysis, which is important for disease diagnosis and monitoring. Liquid marbles (LMs), a kind of particle-coated droplets, as ideal microreactors have been used in various fields. However, their application as analytical platforms is limited due to the difficulty of pretreating complex samples in simple LMs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.0c01237DOI Listing
May 2020
5.636 Impact Factor

Bioinspired high-scattering polymer films fabricated by polymerization-induced phase separation.

Opt Lett 2020 May;45(10):2918-2921

Inspired by the porous scale of the bright white beetle Cyphochilus, a polymerization-induced phase separation method is proposed to fabricate bioinspired high-scattering polymer films with porous structures. With an optimized formulation, the porous films with a mean pore size of ∼200 feature a broadband reflectance of ∼71 at a thickness of 16 µm and are measured to have a transport mean free path of ∼3µ. The porous films with high reflectivity enable the application on light-emitting diodes and have great potential in other similar optoelectronic fields. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.390639DOI Listing

Diblock copolypeptoids: a review of phase separation, crystallization, self-assembly and biological applications.

J Mater Chem B 2020 May 15. Epub 2020 May 15.

Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Polypeptoids are biocompatible, synthetically accessible, chemically and enzymatically stable, chemically diverse, and structurally controllable. As a bioinspired and biomimetic material, it has attracted considerable attention due to its great potential in biological applications including drug and gene delivery, sensing, imaging, molecular recognition, and anti-cancer therapy. Diblock copolypeptoids have especially been of increasing interest in the materials chemistry community because of their capacity to microphase separate and self-assemble to form a variety of nanoarchitectures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0tb00477dDOI Listing

Correlating Artepillin C cytotoxic activity on HEp-2 cells with bioinspired systems of plasma membranes.

Mater Sci Eng C Mater Biol Appl 2020 Jul 8;112:110943. Epub 2020 Apr 8.

São Paulo State University (UNESP), School of Sciences, Humanities and Languages, Assis 19806-900, SP, Brazil.

Artepillin C is the main compound present in propolis from Baccharis dracunculifolia, whose antitumor activity has been the focus of many studies. Herein, we shall investigate the Artepillin C mechanisms of action against cells derived from the oropharyngeal carcinoma (HEp-2). Cytotoxicity tests revealed that the concentrations of Artepillin C required to reduce cell viability by 50% (CC) are dependent on the incubation time, decreasing from 40. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2020.110943DOI Listing

Effect of vibration on insertion force and deflection of bioinspired needle in tissues.

Bioinspir Biomim 2020 May 14. Epub 2020 May 14.

Mechanical Engineering, Temple University College of Engineering, Philadelphia, Pennsylvania, UNITED STATES.

The design of surgical needles used in biopsy procedures have remained fairly standard despite the increase in complexity of surgeries. Higher needle insertion forces and deflection can increase tissue damage and decrease biopsy sample integrity. To overcome these drawbacks, we present a novel bioinspired approach to reduce insertion forces and minimize needle-tip deflection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1748-3190/ab9341DOI Listing

A bioinspired mucoadhesive restores lubrication of degraded cartilage through reestablishment of lamina splendens.

Colloids Surf B Biointerfaces 2020 Apr 30;193:110977. Epub 2020 Apr 30.

University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands. Electronic address:

Adsorbed lubricious films composed of biomacromolecules are natively present at all articulating interfaces in the human body where they provide ultralow friction and maintain normal physiological function. Biolubrication gets impaired due to diseases such as osteoarthritis, in which cartilage damage results from alterations in synovial fluid and lamina splendens composition. Osteoarthritis is treated with hyaluronic acid (HA) orally or via intra-articular injection, but due to the poor adsorption of HA on the cartilage surface in the absence of adhesive molecules, pain relief is temporary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2020.110977DOI Listing

Theoretical approaches to study the optical response of the red-legged honeycreeper's plumage (Cyanerpes cyaneus).

Appl Opt 2020 May;59(13):3901-3909

In this paper, we investigate the unusual color effect exhibited by the plumage of the heads of Cyanerpes cyaneus males, whose color turns from green to turquoise as the angle between the illumination and observation directions is increased. This singular color effect is characteristic of species that have quasi-ordered nanostructures of short-range order within the feather barbs. However, among species of the same family and even within feather patches of the same individual, one can find barbs with different characteristics, both macroscopic (curvature, shape, cross-sectional area) and in their internal microstructure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1364/AO.380307DOI Listing

DNA Origami as Emerging Technology for the Engineering of Fluorescent and Plasmonic-Based Biosensors.

Materials (Basel) 2020 May 9;13(9). Epub 2020 May 9.

Photonic Nanosystems, Department of Physics, Faculty of Science and Medicine, University of Fribourg, Chemin du Musée 3, PER08, 1700 Fribourg, Switzerland.

DNA nanotechnology is a powerful and promising tool for the development of nanoscale devices for numerous and diverse applications. One of the greatest potential fields of application for DNA nanotechnology is in biomedicine, in particular biosensing. Thanks to the control over their size, shape, and fabrication, DNA origami represents a unique opportunity to assemble dynamic and complex devices with precise and predictable structural characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma13092185DOI Listing

The Protective Role of Bark and Bark Fibers of the Giant Sequoia () during High-Energy Impacts.

Int J Mol Sci 2020 May 9;21(9). Epub 2020 May 9.

Plant Biomechanics Group Freiburg, Botanic Garden of the University of Freiburg, University of Freiburg, Schänzlestraße 1, D-79104 Freiburg, Germany.

The influences of (1) a high fiber content, (2) the arrangement of fibers in fiber groups, and (3) a layered hierarchical composition of the bark of the giant sequoia () on its energy dissipation capability are analyzed and discussed regarding the relevance for an application in bioinspired components in civil engineering. The giant sequoia is native to the Sierra Nevada (USA), a region with regular rockfalls. It is thus regularly exposed to high-energy impacts, with its bark playing a major protective role, as can be seen in the wild and has been proven in laboratory experiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21093355DOI Listing

Plant movements as concept generators for the development of biomimetic compliant mechanisms.

Integr Comp Biol 2020 May 12. Epub 2020 May 12.

Plant Biomechanics Group, Botanic Garden, University of Freiburg, Freiburg im Breisgau, Germany.

Plant movements are of increasing interest for biomimetic approaches where hinge-free compliant mechanisms (flexible structures) for applications e.g. in architecture, soft robotics, and medicine are developed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/icb/icaa028DOI Listing

Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior.

Proc Natl Acad Sci U S A 2020 May 11;117(21):11421-11431. Epub 2020 May 11.

Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015;

Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the formation of membraneless organelles, which compartmentalize molecules intracellularly in the absence of a lipid membrane. Identifying the protein sequence features responsible for IDP phase separation is critical for understanding physiological roles and pathological consequences of biomolecular condensation, as well as for harnessing phase separation for applications in bioinspired materials design. To expand our knowledge of sequence determinants of IDP phase separation, we characterized variants of the intrinsically disordered RGG domain from LAF-1, a model protein involved in phase separation and a key component of P granules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.2000223117DOI Listing

Rapid Synthesis of Nucleoside Triphosphates and Analogues.

Curr Protoc Nucleic Acid Chem 2020 Jun;81(1):e108

Institute of Organic Chemistry, University of Freiburg, Freiburg, Germany.

Nucleoside triphosphates (NTPs) are essential biomolecules involved in almost all biological processes, and their study is therefore critical to understanding cellular biology. Here, we describe a chemical synthesis suitable for obtaining both natural and highly modified NTPs, which can, for example, be used as surrogates to probe biological processes. The approach includes the preparation of a reagent that enables the facile introduction and modification of three phosphate units: cyclic pyrophosphoryl P-amidite (c-PyPA), derived from pyrophosphate (P ) and a reactive phosphoramidite (P ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpnc.108DOI Listing

Unidirectional and Selective Proton Transport in Artificial Heterostructured Nanochannels with Nano-to-Subnano Confined Water Clusters.

Adv Mater 2020 May 10:e2001777. Epub 2020 May 10.

Department of Chemical Engineering, Monash University, Clayton, Victoria, 3800, Australia.

The construction of biological proton channel analogues has attracted substantial interest owing to their wide potential in separation of ions, sensing, and energy conversion. Here, metal-organic framework (MOF)/polymer heterogeneous nanochannels are presented, in which water molecules are confined to disordered clusters in the nanometer-sized polymer regions and to ordered chains with unique molecular configurations in the 1D sub-1-nm porous MOF regions, to realize unidirectional, fast, and selective proton transport properties, analogous to natural proton channels. Given the nano-to-subnano confined water junctions, experimental proton conductivities in the polymer-to-MOF direction of the channels are much higher than those in the opposite direction, showing a high rectification up to 500 and one to two orders of magnitude enhancement compared to the conductivity of proton transport in bulk water. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.202001777DOI Listing

Spontaneous transport of air bubbles on bioinspired superhydrophilic triangular patterns.

J Colloid Interface Sci 2020 May 4;575:399-405. Epub 2020 May 4.

Nanoprobe Laboratory for Bio- & Nanotechnology and Biomimetics (NLBB), The Ohio State University, 201 W. 19th Avenue, Columbus, OH 43210-1142, USA. Electronic address:

Air bubbles are interfacial fluid dynamics phenomena in many natural and technological processes. The dynamics of air bubbles is of interest in many applications. In this study, to facilitate the transport of air bubbles, triangular patterns were used, inspired by conical spines of cactus, which develop Laplace pressure gradient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2020.04.124DOI Listing

Multilevel mineral-coated imprinted nanocomposite membranes for template-dependent recognition and separation: A well-designed strategy with PDA/CaCO-based loading structure.

J Colloid Interface Sci 2020 Apr 25;575:356-366. Epub 2020 Apr 25.

Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

In spite of the intense efforts in selective separation field, the utilization and preparation of membrane-associated molecularly imprinted membranes with both enhanced rebinding capacities and high permselectivity performance still remain strong challenges. Herein, the bioinspired PDA-modified porous regenerated cellulose membrane (pRCMs) with mineral-coated multilevel structure was first proposed for the preparation of PDA/CaCO-based imprinted nanocomposite membranes (PCIMs), m-cresol was chosen as the template molecule. Importantly, this bioinspired methodology was redeveloped and optimized to obtain abundant and uniformly distributed CaCO nanocomposite on the surfaces of PDA@pRCMs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2020.04.095DOI Listing