475 results match your criteria Bioinorganic Chemistry And Applications[Journal]


Dithiocarbamates: Challenges, Control, and Approaches to Excellent Yield, Characterization, and Their Biological Applications.

Bioinorg Chem Appl 2019 6;2019:8260496. Epub 2019 Feb 6.

School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg Campus, Scottsville 3209, South Africa.

Progresses made in previous researches on syntheses of dithiocarbamates led to increase in further researches. This paper reviews concisely the challenges experienced during the synthesis of dithiocarbamate and mechanisms to overcome them in order to obtain accurate results. Aspects of its precursor's uses to synthesize adducts, nanoparticles, and nanocomposites are reported. Read More

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http://dx.doi.org/10.1155/2019/8260496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381578PMC
February 2019

Eco-Efficient Biosorbent Based on Residues for the Simultaneous Removal of Pb(II) and Cd(II) Ions from Water System: Sorption and Mechanism.

Bioinorg Chem Appl 2019 2;2019:2814047. Epub 2019 Jan 2.

Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Periférico Norte, Kilómetro 33.5, Chuburná de Hidalgo Inn, Mérida, Yucatán 97203, Mexico.

is a potential source of polyphenols widely available in southern Mexico. This work highlights the extraction of polyphenols from leaves waste (LLEPs) and the evaluation of their efficiency to remove the single and multicomponent Pb(II) and Cd(II) metal ions from aqueous solutions. Batch test conditions were carried out to examine the effects of contact time, initial metal ion concentration, and adsorbent dosage on the biosorption process. Read More

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http://dx.doi.org/10.1155/2019/2814047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334343PMC
January 2019
1 Read

Synthesis and Antibacterial Activity of Polyoxometalates with Different Structures.

Bioinorg Chem Appl 2018 9;2018:9342326. Epub 2018 Dec 9.

Department of Hepatology, The First Hospital, Jilin University, Changchun 130021, China.

A new inorganic-organic hybrid compound, [{Cu(phen)}(HWO)], was synthesized, and its crystal structure was determined. The Keggin anion HWO was grafted with two coordination units {Cu(phen)}, forming an electrically neutral molecule. The antibacterial activity of several polyoxometalate compounds with different anionic structures including the new compound was studied. Read More

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https://www.hindawi.com/journals/bca/2018/9342326/
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http://dx.doi.org/10.1155/2018/9342326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305049PMC
December 2018
6 Reads
2.081 Impact Factor

The Structures, Spectroscopic Properties, and Photodynamic Reactions of Three [RuCl(QN)NO] Complexes (HQN = 8-Hydroxyquinoline and Its Derivatives) as Potential NO-Donating Drugs.

Bioinorg Chem Appl 2018 2;2018:7029376. Epub 2018 Dec 2.

Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China.

The structures and spectral properties of three ruthenium complexes with 8-hydroxyquinoline (Hhqn) and their derivatives 2-methyl-8-quinolinoline (H2mqn) and 2-chloro-8-quiolinoline (H2cqn) as ligands (QN = hqn, 2mqn, or 2cqn) were calculated with density functional theory (DFT) at the B3LYP level. The UV-Vis and IR spectra of the three [RuCl(QN)NO] complexes were theoretically assigned via DFT calculations. The calculated spectra reasonably correspond to the experimentally measured spectra. Read More

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https://www.hindawi.com/journals/bca/2018/7029376/
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http://dx.doi.org/10.1155/2018/7029376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305033PMC
December 2018
8 Reads

Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of against Human Cervical Cancer Cells (HeLA).

Bioinorg Chem Appl 2018 1;2018:9390784. Epub 2018 Nov 1.

Zoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

In this study, silver nanoparticles (AgNPs) were synthesized using aqueous extract of plant. The prepared AgNPs (ND-AgNPs) were examined by ultraviolet-visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscope (SEM), and energy dispersive spectroscopy (EDX). The results obtained from various characterizations revealed that average size of synthesized AgNPs was 33 nm and in face-centered-cubic structure. Read More

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http://dx.doi.org/10.1155/2018/9390784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236914PMC
November 2018
83 Reads
2.081 Impact Factor

Bioremoval of Different Heavy Metals by the Resistant Fungal Strain .

Bioinorg Chem Appl 2018 1;2018:3457196. Epub 2018 Nov 1.

Área Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Autónoma Del Estado de Hidalgo, Zona Universitaria, Rancho Universitario Km 1. C.P. 43600, Tulancingo de Bravo Hidalgo, Mexico.

The objective of this work was to study the resistance and removal capacity of heavy metals by the fungus . We analyzed the resistance to some heavy metals by dry weight and plate: the fungus grew in 2000 ppm of zinc, lead, and mercury, 1200 and 1000 ppm of arsenic (III) and (VI), 800 ppm of fluor and cobalt, and least in cadmium (400 ppm). With respect to their potential of removal of heavy metals, this removal was achieved for zinc (100%), mercury (83. Read More

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http://dx.doi.org/10.1155/2018/3457196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236671PMC
November 2018
2 Reads

Optimization Studies on Recovery of Metals from Printed Circuit Board Waste.

Bioinorg Chem Appl 2018 1;2018:1067512. Epub 2018 Nov 1.

Department of Chemical Engineering, Coimbatore Institute of Technology, Coimbatore 641 014, Tamil Nadu, India.

The aim of the study was to recover copper and lead metal from waste printed circuit boards (PCBs). The electrowinning method is found to be an effective recycling process to recover copper and lead metal from printed circuit board wastes. In order to simplify the process with affordable equipment, a simple ammonical leaching operation method was adopted. Read More

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http://dx.doi.org/10.1155/2018/1067512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236970PMC
November 2018
1 Read

Corrigendum to "Effect of Carboxylic Functional Group Functionalized on Carbon Nanotubes Surface on the Removal of Lead from Water".

Bioinorg Chem Appl 2018 22;2018:2687413. Epub 2018 Oct 22.

Chemistry Department, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.

[This corrects the article DOI: 10.1155/2010/603978.]. Read More

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https://www.hindawi.com/journals/bca/2018/2687413/
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http://dx.doi.org/10.1155/2018/2687413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217903PMC
October 2018
17 Reads

Biogenic Synthesis of Copper and Silver Nanoparticles Using Green Alga and Its Antimicrobial Activity.

Bioinorg Chem Appl 2018 21;2018:7879403. Epub 2018 Oct 21.

Department of Chemistry, Amity University, Gurugram, Haryana, India.

The spread of infectious diseases and the increase in the drug resistance among microbes has forced the researchers to synthesize biologically active nanoparticles. Improvement of the ecofriendly procedure for the synthesis of nanoparticles is growing day-by-day in the field of nanobiotechnology. In the present study, we use the extract of green alga for the synthesis of copper and silver nanoparticles. Read More

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https://www.hindawi.com/journals/bca/2018/7879403/
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http://dx.doi.org/10.1155/2018/7879403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215593PMC
October 2018
10 Reads

Structural Properties and Reactive Site Selectivity of Some Transition Metal Complexes of 2,2'(1E,1'E)-(ethane-1,2-diylbis(azan-1-yl-1-ylidene))bis(phenylmethan-1-yl-1-ylidene)dibenzoic Acid: DFT, Conceptual DFT, QTAIM, and MEP Studies.

Bioinorg Chem Appl 2018 26;2018:4510648. Epub 2018 Sep 26.

Department of Chemistry, Faculty of Science, Research Unit of Noxious Chemistry and Environmental Engineering, University of Dschang, P.O. Box 67, Dschang, Cameroon.

Herein is presented a density functional theory (DFT) study of reactivity and structural properties of transition metal complexes of the Schiff base ligand 2,2'(1E,1'E)-(ethane-1,2-diylbis(azan-1-yl-1-ylidene))bis(phenylmethan-1-yl-1-ylidene)dibenzoic acid (hereafter denoted EDA2BB) with Cu(II), Mn(II), Ni(II), and Co(II). The quantum theory of atoms-in-molecules (QTAIM), conceptual DFT, natural population analysis (NPA), and molecular electrostatic potential (MEP) methods have been used. Results have revealed a distorted octahedral geometry around the central metal ion in each gas phase complex. Read More

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http://dx.doi.org/10.1155/2018/4510648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178161PMC
September 2018

Cytotoxic and Bactericidal Effect of Silver Nanoparticles Obtained by Green Synthesis Method Using Aqueous Extract and Functionalized with 5-Fluorouracil.

Bioinorg Chem Appl 2018 15;2018:6506381. Epub 2018 Oct 15.

Facultad de Ciencias, Universidad Autónoma de San Luis Potosí (UASLP), Avenida Manuel Nava 6, Zona Universitaria, 78290 San Luis Potosí, Mexico.

Nanomaterials obtained by green synthesis technologies have been widely studied in recent years owing to constitute cost-effective and environmental-friendly methods. In addition, there are several works that report the simultaneous performance of the reducer agent as a functionalizing agent, modifying the properties of the nanomaterial. As a simple and economical synthesis methodology, this work presents a method to synthesize silver nanoparticles (AgNPs) using aqueous extract and functionalized with 5-fluorouracil (5-FU). Read More

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https://www.hindawi.com/journals/bca/2018/6506381/
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http://dx.doi.org/10.1155/2018/6506381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205100PMC
October 2018
13 Reads

Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands.

Bioinorg Chem Appl 2018 1;2018:8276139. Epub 2018 Oct 1.

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.

To overcome the side effects of and resistance to cisplatin, a variety of Pt(IV) prodrugs were designed and synthesized via different modifications including combination with lipid chains to increase hydrophobicity, conjugation with short peptide chains or nanoparticles to improve drug delivery, or addition of bioactive ligands to the axial positions of Pt(IV) complexes to exert dual-function effects. This review summarizes the recent progress in the development of Pt(IV) prodrugs conjugated with bioactive-targeting ligands, including histone deacetylase inhibitors, p53 agonists, alkylating agents, and nonsteroidal anti-inflammatory agents. Although Pt(IV) complexes that conjugated with bioactive ligands show satisfactory anticancer effects, none has been approved for clinical use. Read More

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https://www.hindawi.com/journals/bca/2018/8276139/
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http://dx.doi.org/10.1155/2018/8276139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191961PMC
October 2018
16 Reads

Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies.

Bioinorg Chem Appl 2018 6;2018:7176040. Epub 2018 Sep 6.

Biology Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, Saudi Arabia.

A series of perimidine derivatives (L) were prepared and characterized by IR, H·NMR, mass spectroscopy, UV-Vis, XRD, thermal, and SEM analysis. Five VO(II) complexes were synthesized and investigated by most previous tools besides the theoretical usage. A neutral tetradentate mode of bonding is the general approach for all binding ligands towards bi-vanadyl atoms. Read More

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http://dx.doi.org/10.1155/2018/7176040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151213PMC
September 2018

Study on Adsorption of Cu and Ba from Aqueous Solutions Using Nanoparticles of () and ().

Bioinorg Chem Appl 2018 9;2018:3936178. Epub 2018 Sep 9.

Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Wild herbs ( () and ()) were used as environment-friendly adsorbents in this study. The adsorbents were used for adsorption of Cu and Ba from water. The adsorption of heavy metals onto and was dependent on particle size, dose, and solution pH. Read More

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http://dx.doi.org/10.1155/2018/3936178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151223PMC
September 2018
2 Reads

Synthesis and Characterization of -Dichlorotetrakis(imidazole)cobalt(III) Chloride: A New Cobalt(III) Coordination Complex with Potential Prodrug Properties.

Bioinorg Chem Appl 2018 3;2018:4560757. Epub 2018 Sep 3.

Department of Chemistry and Biochemistry, Fort Lewis College, 1000 Rim Dr., Durango, CO 81301, USA.

Numerous therapies for the treatment of cancer have been explored with increasing evidence that the use of metal-containing compounds could prove advantageous as anticancer therapeutics. Previous works on Ru(III) complexes suggest that structurally similar Co(III) complexes may provide good alternative, low-cost, effective prodrugs. Herein, a new complex, -[Co(imidazole)Cl]Cl (), has been synthesized in high yields utilizing ligand exchange under refluxing conditions. Read More

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http://dx.doi.org/10.1155/2018/4560757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140278PMC
September 2018

Synthesis, Characterization, and Antimicrobial Activity of Novel Sulfonated Copper-Triazine Complexes.

Bioinorg Chem Appl 2018 29;2018:2530851. Epub 2018 Aug 29.

Department of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Metallotriazine complexes possess interesting biological and medicinal properties, and the present study focuses on the synthesis, characterization, and antimicrobial activity of four novel copper-triazine derivatives in search of potent antibacterial and antifungal drug leads. In this study, 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4,4'-disulfonic acid monosodium salt (L1, ferrozine) and 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5,5'-disulfonic acid disodium salt (L2, ferene) have been used as ligands to study the complexation towards copper(II). The synthesized complexes, [CuCl(ferrozine)]·7HO·MeOH (), [CuCl(ferrozine)]·5HO·MeOH (), [CuCl(ferene)]·HO·MeOH (), and [CuCl(ferene)]·HO·MeOH (), have been characterized spectroscopically, and preliminary bioassays have been carried out. Read More

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http://dx.doi.org/10.1155/2018/2530851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136538PMC
August 2018
2 Reads

An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules.

Bioinorg Chem Appl 2018 12;2018:8547364. Epub 2018 Aug 12.

Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, Canada H3A 3K6.

Carbon monoxide (CO) has long been known as the "silent killer" owing to its ability to form carboxyhemoglobin-the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called "carbon monoxide releasing molecules (CORMs). Read More

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http://dx.doi.org/10.1155/2018/8547364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109489PMC

Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death.

Bioinorg Chem Appl 2018 1;2018:7578965. Epub 2018 Aug 1.

Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.

Death receptors (DR4 and DR5) offer attractive targets for cancer treatment because cancer cell death can be induced by apoptotic signal upon binding of death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with death receptors. Cyclometalated iridium(III) complexes such as -Ir(tpy) (tpy = 2-(4-tolyl)pyridine) possess a -symmetric structure like TRAIL and exhibit excellent luminescence properties. Therefore, cyclometalated Ir complexes functionalized with DR-binding peptide motifs would be potent TRAIL mimics to detect cancer cells and induce their cell death. Read More

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http://dx.doi.org/10.1155/2018/7578965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092981PMC
August 2018
3 Reads

A Review on Green Synthesis, Biomedical Applications, and Toxicity Studies of ZnO NPs.

Bioinorg Chem Appl 2018 1;2018:3569758. Epub 2018 Aug 1.

Department of Biomedical Sciences, School of Biosciences and Technology, VIT, Vellore, Tamil Nadu, India.

The advance of reliable and eco-friendly strategies for the development of nanoparticles is a fundamental key to the discipline of nanotechnology. Nanoparticles have been continuously evaluated and have been used in many industrial applications for a decade. In particular, the role of zinc oxide nanoparticles (ZnO NPs) has received a great interest because of various properties such as UV filter properties and photochemical, antifungal, high catalyst, and antimicrobial activities. Read More

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http://dx.doi.org/10.1155/2018/3569758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093006PMC
August 2018
5 Reads

Biomimetic Approach to CO Reduction.

Authors:
Ilaria Gamba

Bioinorg Chem Appl 2018 1;2018:2379141. Epub 2018 Aug 1.

Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.

The development of artificial photosynthetic technologies able to produce solar-fuels from CO reduction is a fundamental task that requires the employment of specific catalysts being accomplished. Besides, effective catalysts are also demanded to capture atmospheric CO, mitigating the effects of its constantly increasing emission. Biomimetic transition metal complexes are considered ideal platforms to develop efficient and selective catalysts to be implemented in electrocatalytic and photocatalytic devices. Read More

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https://www.hindawi.com/journals/bca/2018/2379141/
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http://dx.doi.org/10.1155/2018/2379141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093055PMC
August 2018
17 Reads

Structure-Based Drug Design for Cytochrome P450 Family 1 Inhibitors.

Bioinorg Chem Appl 2018 25;2018:3924608. Epub 2018 Jul 25.

Department of Inorganic and Analytical Chemistry, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University in Toruń, Dr A. Jurasza 2, 85-089 Bydgoszcz, Poland.

Cytochromes P450 are a class of metalloproteins which are responsible for electron transfer in a wide spectrum of reactions including metabolic biotransformation of endogenous and exogenous substrates. The superfamily of cytochromes P450 consists of families and subfamilies which are characterized by a specific structure and substrate specificity. Cytochromes P450 family 1 (CYP1s) play a distinctive role in the metabolism of drugs and chemical procarcinogens. Read More

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https://www.hindawi.com/journals/bca/2018/3924608/
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http://dx.doi.org/10.1155/2018/3924608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083639PMC
July 2018
7 Reads

Synthesis of -Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications.

Bioinorg Chem Appl 2018 17;2018:8097483. Epub 2018 Jul 17.

Biology Department, Science College, Microbiology Research Laboratory, Bahir Dar University, Bahir Dar, Ethiopia.

New organic salts were synthesized by quaternizing 1,10-phenanthroline using 1-bromotetradecane. The first step yielded an organic salt of formula [CHN]Br. Anion exchange reaction using Li[(CFSO)N] resulted in a more stable salt of formula [CHN][(CFSO)N]. Read More

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https://www.hindawi.com/journals/bca/2018/8097483/
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http://dx.doi.org/10.1155/2018/8097483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079542PMC
July 2018
19 Reads
2.081 Impact Factor

Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline.

Bioinorg Chem Appl 2018 5;2018:8478152. Epub 2018 Jul 5.

School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.

Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CHOH)]·CHOH (), [Ni(naph-L-phe)(phen)(CHOH)] (), and [Ni(-van-L-phe)(phen)(CHOH)]·5CHOH () (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, -van-L-phe = a Schiff base derived from -vanillin and L-phenylalanine, and phen = 1,10-phenanthroline), have been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. The interactions of these complexes with CT-DNA were studied by UV-Vis absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy, and viscosity measurements. The binding constant () values of 1. Read More

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http://dx.doi.org/10.1155/2018/8478152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057355PMC
July 2018
15 Reads

The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications.

Bioinorg Chem Appl 2018 5;2018:1062562. Epub 2018 Jul 5.

State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.

Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger excess reactive oxygen species (ROS) production, release zinc ions, and induce cell apoptosis. Read More

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http://dx.doi.org/10.1155/2018/1062562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057429PMC

Study of Isothermal, Kinetic, and Thermodynamic Parameters for Adsorption of Cadmium: An Overview of Linear and Nonlinear Approach and Error Analysis.

Bioinorg Chem Appl 2018 3;2018:3463724. Epub 2018 Jul 3.

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka 2014, Saudi Arabia.

Reports about presence and toxicity of Cd in different chemical industrial effluents prompted the researchers to explore some economical, rapid, sensitive, and accurate methods for its determination and removal from aqueous systems. In continuation of series of investigations, adsorption of Cd onto the stem of is proposed in the present work. Optimization of parameters affecting sorption potential of Cd including pH, contact time, temperature, sorbent dose, and concentration of sorbate was carried out to determine best suited conditions for maximum removal of sorbate. Read More

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http://dx.doi.org/10.1155/2018/3463724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051333PMC
July 2018
1 Read

Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer.

Bioinorg Chem Appl 2018 2;2018:4924186. Epub 2018 Jul 2.

Department of Microbiology, School of Science, RK University, Kasturbadham, Rajkot 360020, India.

Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade. Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal plant tuber extract (GSTE). The synthesis of the nanoparticles was completed within 5 hours at 100°C which was confirmed by development of dark brown and black colour for PtNPs and PdNPs, respectively, along with enhancement of the peak intensity in the UV-visible spectra. Read More

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http://dx.doi.org/10.1155/2018/4924186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051271PMC
July 2018
3 Reads
2.081 Impact Factor

A Diversified Spectrometric and Molecular Docking Technique to Biophysical Study of Interaction between Bovine Serum Albumin and Sodium Salt of Risedronic Acid, a Bisphosphonate for Skeletal Disorders.

Bioinorg Chem Appl 2018 28;2018:6954951. Epub 2018 Jun 28.

Department of Chemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka 570 006, India.

The binding interaction between bovine serum albumin (BSA) and sodium salt of risedronic acid (RSN) was studied by using the FT-IR (Fourier transform infrared), UV-Vis (ultraviolet-visible), fluorescence (emission and synchronous), CD (circular dichroism) spectrometric, and computational (molecular docking) techniques at 289, 297, and 305 K temperatures with physiological buffer of pH 7.40. The conformational and secondary structural changes observed for BSA from CD spectra and by curve fitting procedure were applied to Fourier self-deconvolution in FT-IR spectra. Read More

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http://dx.doi.org/10.1155/2018/6954951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046188PMC
June 2018
5 Reads

Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies.

Bioinorg Chem Appl 2018 27;2018:2452869. Epub 2018 Jun 27.

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysuru, Karnataka 570 006, India.

Two novel oxidovanadium(IV) complexes with a new bidentate (O- and N-) imine-based ligand 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol (HL) were synthesized under in situ experimental condition where VOSO acts as a kinetic template in the ratio 2 : 1 (L : M) and mixed ligand complex using 1,10-phenanthroline (phen) in 1 : 1 : 1 (L : M : phen) ratio. The synthesized compounds were structurally characterized by microanalysis, magnetic susceptibility, FTIR, electronic spectra, TG/DTA, ESR, and molar conductance studies. Based on the spectral studies, the complexes have the general composition [VO(L)] (C ) and [VO(L)phen] (C ) in a square pyramid geometrical fashion. Read More

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https://www.hindawi.com/journals/bca/2018/2452869/
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http://dx.doi.org/10.1155/2018/2452869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040275PMC
June 2018
4 Reads

Corrigendum to "Formation of Silver Nanoclusters from a DNA Template Containing Ag(I)-Mediated Base Pairs".

Bioinorg Chem Appl 2018 21;2018:7897953. Epub 2018 Jun 21.

Institut für Anorganische und Analytische Chemie, Westfälische Wilhelms-Universität Münster, Corrensstraße 28/30, 48149 Münster, Germany.

[This corrects the article DOI: 10.1155/2016/7485125.]. Read More

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http://dx.doi.org/10.1155/2018/7897953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032650PMC

Pharmacological and Toxicological Threshold of Bisammonium Tetrakis 4-(,-Dimethylamino)pyridinium Decavanadate in a Rat Model of Metabolic Syndrome and Insulin Resistance.

Bioinorg Chem Appl 2018 19;2018:2151079. Epub 2018 Jun 19.

Centro de Química, ICUAP, Benemérita Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, 72570 Puebla, PUE, Mexico.

Vanadium(IV/V) compounds have been studied as possible metallopharmaceutical drugs against diabetes mellitus. However, mechanisms of action and toxicological threshold have been tackled poorly so far. In this paper, our purposes were to evaluate the metabolic activity on dyslipidemia and dysglycemia, insulin signaling in liver and adipose tissue, and toxicology of the title compound. Read More

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http://dx.doi.org/10.1155/2018/2151079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031092PMC
June 2018
5 Reads

Exploration on the Interaction Ability of Antitumor Compound Bis-[2,6-difluoro--(hydroxyl-<κ>)benzamidato-<κ>]dibutylitin(IV) with Human Peroxisome Proliferator-Activated Receptor hPPAR.

Bioinorg Chem Appl 2018 10;2018:3063271. Epub 2018 Jun 10.

School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China.

Diorganotin(IV) antitumor compound bis-[2,6-difluoro--(hydroxyl-<κ>)benzamidato-<κ>] (DBDF2,6T) was one of the novel patent organotin compounds with high antitumor activity and relatively low toxicity. In this study, several methods were used to study the interaction between DBDF2,6T and hPPAR protein, including fluorescence quenching, three-dimensional (3D) fluorescence, drug affinity responsive target stability (DARTS), ultrafiltration-LC, and molecular docking. According to the experimental results, the quenching process of the hPPAR protein was induced by static quenching mode to form a nonradiative ground-state complex with DBDF2,6T spontaneously, mainly through the hydrophobic force. Read More

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http://dx.doi.org/10.1155/2018/3063271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015708PMC

The Anticancer Activities of Some Nitrogen Donor Ligands Containing bis-Pyrazole, Bipyridine, and Phenanthroline Moiety Using Docking Methods.

Bioinorg Chem Appl 2018 4;2018:5796287. Epub 2018 Jun 4.

School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg 3201, South Africa.

The anticancer study of nitrogen-chelating ligands can be of tremendous help in choosing ligands for the anticancer metal complexes design especially with ruthenium(II). The inhibitory anticancer activities of some nitrogen-chelating ligands containing bis-pyrazole, bipyridine, and phenanthroline were studied using experimental screening against cancer cell and theoretical docking methods. anticancer activities showed compound as the most promising inhibitor, and the computational docking further indicates its strong inhibitory activities towards some cancer-related receptors. Read More

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http://dx.doi.org/10.1155/2018/5796287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008838PMC
June 2018
22 Reads

Hydrothermal Synthesis, Structural Characterization, and Interaction Mechanism with DNA of Copper(II) Complex Containing 2,2'-Bipyridine.

Bioinorg Chem Appl 2018 22;2018:8459638. Epub 2018 May 22.

School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.

A Cu(II) complex [Cu(bipy)(HO)(SO)] (bipy = 2,2'-bipyridine) was synthesized by hydrothermal method and characterized structurally by elemental analyses, single crystal X-ray diffraction, infrared spectra, and thermogravimetry and differential scanning calorimetry. The Cu(II) was hexacoordinated by two N atoms from bipy, two O atoms from different sulfate radical anions, and two O atoms from two water molecules, forming a slightly distorted octahedral geometry, and bridged by sulfato groups into polymeric chains. Under the condition of physiological pH, the interaction mechanism between the complex and hsDNA was explored with acridine orange as a fluorescence probe by spectroscopic methods. Read More

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http://dx.doi.org/10.1155/2018/8459638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987339PMC
May 2018
9 Reads

Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts.

Bioinorg Chem Appl 2018 22;2018:1439810. Epub 2018 May 22.

Department of Chemistry, Trakya University, 22030 Edirne, Turkey.

Four newly synthesized imidazolium salts were characterized by nuclear magnetic resonance, vibrational spectra, and mass spectra. Then, the density functional theory calculations were performed to obtain the molecular configurations on which the theoretical nuclear magnetic resonance and infrared spectra were consequently obtained. The comparison of calculated spectra with the experimental spectra for each molecule leads to the conclusion that the theoretical results can be assumed to be a good approach to their molecular configurations. Read More

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http://dx.doi.org/10.1155/2018/1439810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987347PMC
May 2018
5 Reads

Coordination Behavior of Ni, Cu, and Zn in Tetrahedral 1-Methylimidazole Complexes: A DFT/CSD Study.

Authors:
Samuel Tetteh

Bioinorg Chem Appl 2018 14;2018:3157969. Epub 2018 May 14.

Department of Chemistry, School of Physical Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.

The interaction between nickel (Ni), copper (Cu), and zinc (Zn) ions and 1-methylimidazole has been studied by exploring the geometries of eleven crystal structures in the Cambridge Structural Database (CSD). The coordination behavior of the respective ions was further investigated by means of density functional theory (DFT) methods. The gas-phase complexes were fully optimized using B3LYP/GENECP functionals with 6-31G and LANL2DZ basis sets. Read More

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http://dx.doi.org/10.1155/2018/3157969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977000PMC
May 2018
1 Read

Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations.

Bioinorg Chem Appl 2018 14;2018:2727619. Epub 2018 May 14.

Chemistry Department, College of Applied Sciences, Umm Al-Qura University, Mecca, Saudi Arabia.

Four pyrazolone derivatives and their corresponding silver complexes were synthesized and characterized. Based on elemental analysis, 1 : 2 (M : L) molar ratio was suggested for all inspected complexes. H, C NMR, mass, UV-Vis, TGA, and IR were the spectral tools used for describing the formulae. Read More

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http://dx.doi.org/10.1155/2018/2727619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976992PMC
May 2018
1 Read

Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation.

Bioinorg Chem Appl 2018 2;2018:8291393. Epub 2018 May 2.

Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Platelet activation has been reported to play a major role in arterial thrombosis, cancer metastasis, and progression. Recently, we developed a novel Ir(III)-based compound, [Ir(Cp)1-(2-pyridyl)-3-(4-dimethylaminophenyl)imidazo[1,5-a]pyridine Cl]BF or Ir-6 and assessed its effectiveness as an antiplatelet drug. Ir-6 exhibited higher potency against human platelet aggregation stimulated by collagen. Read More

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http://dx.doi.org/10.1155/2018/8291393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954965PMC
May 2018
4 Reads

Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexes.

Bioinorg Chem Appl 2018 8;2018:3294948. Epub 2018 May 8.

Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia.

Dinuclear platinum(II) complexes, [{Pt(en)Cl}(-qx)]Cl·2HO (), [{Pt(en)Cl}(-qz)](ClO) (), and [{Pt(en)Cl}(-phtz)]Cl·4HO (), were synthesized and characterized by different spectroscopic techniques. The crystal structure of was determined by single-crystal X-ray diffraction analysis, while the DFT M06-2X method was applied in order to optimize the structures of . The chlorido Pt(II) complexes were converted into the corresponding aqua species , and their reactions with an equimolar amount of Ac-L-Met-Gly and Ac-L-His-Gly dipeptides were studied by H NMR spectroscopy in the pH range 2. Read More

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http://dx.doi.org/10.1155/2018/3294948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967607PMC
May 2018
17 Reads

Metal Nanoparticles: Thermal Decomposition, Biomedicinal Applications to Cancer Treatment, and Future Perspectives.

Bioinorg Chem Appl 2018 18;2018:9354708. Epub 2018 Apr 18.

Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.

Monodispersed forms of metal nanoparticles are significant to overcome frightening threat of cancer. This review examined pragmatically thermal decomposition as one of the best ways to synthesize monodispersed metal nanoparticles which are stable and of small particle sizes. Controlled morphology for delivery of anticancer agent to specific cells can also be obtained with thermal decomposition. Read More

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http://dx.doi.org/10.1155/2018/9354708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932507PMC

Adsorptive Removal of Hexavalent Chromium by Diphenylcarbazide-Grafted Nutshell Powder.

Bioinorg Chem Appl 2018 19;2018:6171906. Epub 2018 Apr 19.

Department of Chemistry, Faculty of Applied and Computer Sciences, Vaal University of Technology, Private Bag X021, Vanderbijlpark 1911, South Africa.

nutshell powder oxidized by hydrogen peroxide solutions (MHP) was functionalized by immobilizing 1,5'-diphenylcarbazide (DPC) on its surface. The effectiveness of grafting was confirmed by the Fourier transform infrared spectrum due to the presence of NH and C=C stretches at 3361, 1591, and 1486 cm, respectively, on the grafted material which were absent in the nongrafted material. Thermogravimetric analysis revealed that the presence of DPC on the surface of shells lowered the thermal stability from 300°C to about 180°C owing to the volatile nature of DPC. Read More

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http://dx.doi.org/10.1155/2018/6171906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933043PMC
April 2018
1 Read

Impact of Different Serum Potassium Levels on Postresuscitation Heart Function and Hemodynamics in Patients with Nontraumatic Out-of-Hospital Cardiac Arrest.

Bioinorg Chem Appl 2018 5;2018:5825929. Epub 2018 Apr 5.

Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: Sustained return of spontaneous circulation (ROSC) can be initially established in patients with out-of-hospital cardiac arrest (OHCA); however, the early postresuscitation hemodynamics can still be impaired by high levels of serum potassium (hyperkalemia). The impact of different potassium levels on early postresuscitation heart function has remained unclear. We aim to analyze the relationship between different levels of serum potassium and postresuscitation heart function during the early postresuscitation period (the first hour after achieving sustained ROSC). Read More

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http://dx.doi.org/10.1155/2018/5825929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907484PMC
April 2018
2 Reads
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Synthesis, Characterization, and Biological Evaluation of Unimetallic and Heterobimetallic Complexes of Bivalent Copper.

Bioinorg Chem Appl 2018 12;2018:2467463. Epub 2018 Apr 12.

Department of Chemistry, Kurukshetra University, Kurukshetra 136 119, India.

We present an inclusive characterization of the unimetallic and heterobimetallic complexes of copper synthesized using CuCl and diamine (4-fluoro 1,2-phenylenediamine) resulting in monometallic complex which further undergoes treatment with organometallic dichlorides of group 4 and 14 in 1 : 2 molar ratio resulting in heterobimetallic complexes. These complexes thoroughly characterized using various physical, analytical, and spectroscopic techniques indicate square planar and distorted octahedral geometry for the synthesized unimetallic and heterobimetallic complexes, respectively. These complexes were evaluated for their antimicrobial efficacy against various bacterial and fungal strains while hepatoprotective activity was also examined in male albino rats. Read More

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http://dx.doi.org/10.1155/2018/2467463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925014PMC

-Carboline Silver Compound Binding Studies with Human Serum Albumin: A Comprehensive Multispectroscopic Analysis and Molecular Modeling Study.

Bioinorg Chem Appl 2018 25;2018:9782419. Epub 2018 Mar 25.

Surfactant Research Chair, Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

-Carbolines (Cs) belong to the naturally occurring alkaloid family, derived from 9H-pyrido[3,4-b]indole, also known as norharmane (Hnor). Knowing the importance of the Cs alkaloid family in biological processes, a comprehensive binding study is reported of four Ag(I) compounds containing the ligand Hnor and having different counteranions, namely, NO, ClO, BF, and PF, with human serum albumin (HSA) as a model protein. Different approaches like UV-visible, fluorescence spectroscopy, circular dichroism (CD), and molecular docking studies have been used for this purpose. Read More

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http://dx.doi.org/10.1155/2018/9782419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889910PMC
March 2018
5 Reads

Synthesis, Structural Characterization, and Antibacterial Activity of Novel Erbium(III) Complex Containing Antimony.

Bioinorg Chem Appl 2018 20;2018:4313197. Epub 2018 Mar 20.

School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.

The novel 3D edta-linked heterometallic complex [SbEr(edta)(HO)]NO·4HO (Hedta = ethylenediaminetetraacetic acid) was synthesized and characterized by elemental analyses, single-crystal X-ray diffraction, powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and thermal analysis. The complex crystallizes in the monoclinic system with space group . In the complex, each erbium(III) ion is connected with antimony(III) ions bridging by four carboxylic oxygen atoms, and in each [Sb(edta)] anion, the antimony(III) ion is hexacoordinated by two nitrogen atoms and four oxygen atoms from the edta ions, together with a lone electron pair at the equatorial position. Read More

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http://dx.doi.org/10.1155/2018/4313197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884401PMC
March 2018
4 Reads

Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes.

Bioinorg Chem Appl 2018 18;2018:7563820. Epub 2018 Feb 18.

Department of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Four Zn(II) complexes containing a pyridyl triazine core (1 = 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5',5″-disulfonic acid disodium salt and 2 = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4',4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as [Zn(L1)Cl]·5HO·ZnCl (), [Zn(L1)Cl]·4HO·2CHOH (), [Zn(L2)Cl]·3HO·CHOH (), and [Zn(L2)Cl] (). The synthesized complexes are water soluble, making them good candidates for biological applications. All four complexes have been characterized by elemental analysis and H NMR, IR, and UV-Vis spectroscopy. Read More

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http://dx.doi.org/10.1155/2018/7563820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835287PMC
February 2018

Structural Basis for pH-Dependent Oligomerization of Dihydropyrimidinase from PAO1.

Bioinorg Chem Appl 2018 30;2018:9564391. Epub 2018 Jan 30.

School of Biomedical Sciences, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Rd., Taichung, Taiwan.

Dihydropyrimidinase, a dimetalloenzyme containing a carboxylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase, dihydroorotase, hydantoinase, and imidase. Unlike all known dihydropyrimidinases, which are tetrameric, pseudomonal dihydropyrimidinase forms a dimer at neutral pH. In this paper, we report the crystal structure of dihydropyrimidinase at pH 5. Read More

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http://dx.doi.org/10.1155/2018/9564391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832032PMC
January 2018

Adsorption Characteristics of Bixin on Acid- and Alkali-Treated Kaolinite in Aprotic Solvents.

Bioinorg Chem Appl 2018 18;2018:3805654. Epub 2018 Jan 18.

Université de Toulouse, INP-ENSIACET, Laboratoire de Chimie Agro-industrielle (LCA), 4 Allée Monso, 31030 Toulouse, France.

The adsorption of bixin in aprotic solvents onto acid- and alkali-treated kaolinite was investigated. Kaolinite was treated three times, for 6 h each, with 8 M HCl or 5 M KOH. The adsorbents were characterized by XRD, FT-IR, EDS, and BET-N. Read More

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http://dx.doi.org/10.1155/2018/3805654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822873PMC
January 2018

Chemical Composition and Porosity Characteristics of Various Calcium Silicate-Based Endodontic Cements.

Authors:
Seok Woo Chang

Bioinorg Chem Appl 2018 1;2018:2784632. Epub 2018 Feb 1.

Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea.

Chemical composition and porosity characteristics of calcium silicate-based endodontic cements are important determinants of their clinical performance. Therefore, the aim of this study was to investigate the chemical composition and porosity characteristics of various calcium silicate-based endodontic cements: MTA-angelus, Bioaggregate, Biodentine, Micromega MTA, Ortho MTA, and ProRoot MTA. The specific surface area, pore volume, and pore diameter were measured by the porosimetry analysis of N2 adsorption/desorption isotherms. Read More

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https://www.hindawi.com/journals/bca/2018/2784632/
Publisher Site
http://dx.doi.org/10.1155/2018/2784632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816893PMC
February 2018
11 Reads

Co(II) Coordination in Prokaryotic Zinc Finger Domains as Revealed by UV-Vis Spectroscopy.

Bioinorg Chem Appl 2017 14;2017:1527247. Epub 2017 Dec 14.

Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania-Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.

Co(II) electronic configuration allows its use as a spectroscopic probe in UV-Vis experiments to characterize the metal coordination sphere that is an essential component of the functional structure of zinc-binding proteins and to evaluate the metal ion affinities of these proteins. Here, exploiting the capability of the prokaryotic zinc finger to use different combinations of residues to properly coordinate the structural metal ion, we provide the UV-Vis characterization of Co(II) addition to Ros87 and its mutant Ros87_C27D which bears an unusual CysAspHis coordination sphere. Zinc finger sites containing only one cysteine have been infrequently characterized. Read More

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http://dx.doi.org/10.1155/2017/1527247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745721PMC
December 2017

Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes.

Bioinorg Chem Appl 2017 18;2017:4276919. Epub 2017 Oct 18.

Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China.

Using estrone and pregnenolone as starting materials, some steroidal copper complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide or diazanyl pyridine and then complexation of steroidal thiosemicarbazones or steroidal diazanyl pyridines with Cu (II). The complexes were characterized by IR, NMR, and HRMS. The synthesized compounds were screened for their cytotoxicity against HeLa, Bel-7404, and 293T cell lines in vitro. Read More

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http://dx.doi.org/10.1155/2017/4276919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664251PMC
October 2017
7 Reads