Search our Database of Scientific Publications and Authors

I’m looking for a

    1511 results match your criteria Bioinformation[Journal]

    1 OF 31

    Characterization of a hypothetical protein YVRE from Bacillus subtilis indicates its key role as glucono-lactonase in pentose phosphate pathway and glucose metabolism.
    Bioinformation 2017 31;13(12):430-438. Epub 2017 Dec 31.
    Department of Biotechnology, Sir M Visvesvaraya Institute of Technology, Hunasemaranahalli, Bangalore 562157.
    Hypothetical proteins are functionally uncharacterized proteins with assigned function using sequence annotation tools. Almost half of the coding regions of several genomes are hypothetical proteins. Therefore, it is of our interest to characterize a hypothetical protein YVRE from the model system Bacillus subtilis using known data. Read More

    Computer aided epitope design as a peptide vaccine component against Lassa virus.
    Bioinformation 2017 31;13(12):417-429. Epub 2017 Dec 31.
    Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh.
    Lassa virus (LASV) is an arena virus causing hemorrhagic fever and it is endemic in several regions of West Africa. The disease-causing virus records high mortality rate in endemic regions due to lack of appropriate treatment and prevention strategies. Therefore, it is of interest to design and develop viable vaccine components against the virus. Read More

    Recent trends in antimicrobial peptide prediction using machine learning techniques.
    Bioinformation 2017 31;13(12):415-416. Epub 2017 Dec 31.
    Shiv Nadar University, Gautam Budha Nagar, U.P 201314.
    The importance to develop effective alternatives to known antibiotics due to increased microbial resistance is gaining momentum in recent years. Therefore, it is of interest to predict, design and computationally model Antimicrobial Peptides (AMPs). AMPs are oligopeptides with varying size (from 5 to over100 residues) having key role in innate immunity. Read More

    Telenursing: Bioinformation Cornerstone in Healthcare for the 21st Century.
    Bioinformation 2017 31;13(12):412-414. Epub 2017 Dec 31.
    Oral Biology & Medicine, School of Dentistry, Center for the Health Sciences University of California Los Angeles, USA.
    Bioinformation is at the very core of 21st-century healthcare. Telehealth consists of the range of healthcare-related services delivered through bioinformation-aided telecommunications across health-related disciplines, including nursing. Whereas it is clear that bedside patient-centered nursing can never be replaced, recent developments in bioinformation-aided telenursing will undoubtedly contribute to improving healthcare effectiveness and efficacy. Read More

    Artificial Intelligence and Virology - quo vadis.
    Bioinformation 2017 31;13(12):410-411. Epub 2017 Dec 31.
    Division of Infectious Diseases and International Health, Department of Internal Medicine, Tampa General Hospital, University of South Florida, Morsani College of Medicine, Tampa, FL 33606, USA.
    Artificial Intelligence (AI), robotics, co-robotics (cobots), quantum computers (QC), include surges of scientific endeavor to produce machines (mechanical and software) among numerous types and constructions that are accelerating progress to defeat infectious diseases. There is a plethora of additional applications and uses of these methodologies and technologies for the understanding of biomedicine through bioinformation discovery. Therefore, we briefly outline the use of such techniques in virology. Read More

    Current views and challenges on clinical cholera.
    Bioinformation 2017 31;13(12):405-409. Epub 2017 Dec 31.
    Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL 33606, USA.
    Cholera, an acute diarrheal infection has become a major global threat. Vibrio cholerae the causative agent of cholera has been responsible for six previous pandemics since 1817 that spanned four continents and Australia with the seventh pandemic ongoing since 1961. Two serogroups of V. Read More

    Current trends for customized biomedical software tools.
    Bioinformation 2017 31;13(12):402-404. Epub 2017 Dec 31.
    Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
    In the past, biomedical scientists were solely dependent on expensive commercial software packages for various applications. However, the advent of user-friendly programming languages and open source platforms has revolutionized the development of simple and efficient customized software tools for solving specific biomedical problems. Many of these tools are designed and developed by biomedical scientists independently or with the support of computer experts and often made freely available for the benefit of scientific community. Read More

    Antifreeze proteins.
    Bioinformation 2017 31;13(12):400-401. Epub 2017 Dec 31.
    Chair of Medical Biochemistry, Jagiellonian University - Medical College, Kopernika 7, 31-034 Krakow, Poland.
    The antifreeze protein (AFP) activity is explained using two models. The first model is using ice binding and the second is using antiice structuralization of water molecules. The description of AFP function using anti-ice structuralization of water molecules is less explored. Read More

    Current trends in small molecule discovery targeting key cellular signaling events towards the combined management of diabetes and obesity.
    Bioinformation 2017 31;13(12):394-399. Epub 2017 Dec 31.
    Department of Biotechnology, Anna University, Chennai Tamilnadu, India - 600 025.
    Non-insulin dependent diabetes mellitus, also known as Type 2 diabetes is a polygenic disorder leading to abnormalities in the carbohydrate and lipid metabolism. The major contributors in the pathophysiology of type 2 diabetes (T2D) include resistance to insulin action, β cell dysfunction, an abnormality in glucose metabolism and storage, visceral obesity and to some extent inflammation and oxidative stress. Insulin resistance, along with a defect in insulin secretion by the pancreatic β cells is instrumental towards progression to hyperglycemia. Read More

    Molecular docking based screening of a simulated HIF-1 protein model for potential inhibitors.
    Bioinformation 2017 30;13(11):388-393. Epub 2017 Nov 30.
    Centre for agricultural Bioinformatics, ICAR-IASRI (Indian Agricultural Statistics Research Institute), Library Avenue, Pusa, New Delhi - 110012, India.
    Hypoxia inducible factor-1(HIF-1) is a bHLH-family transcription factor that control genes involved in glucolysis, angiogenesis, migration, as well as invasion factors that are important for tumor progression and metastasis. HIF-1, a hetero dimer of HIF-1α and HIF-1β, binds to the hypoxia responsive genes, such as vascular endothelial growth factor (VEGF). It is one the molecular target for angiogenesis. Read More

    Insights from the protein-protein interaction network analysis of Mycobacterium tuberculosis toxin-antitoxin systems.
    Bioinformation 2017 30;13(11):380-387. Epub 2017 Nov 30.
    Centre for Biotechnology, Maharshi Dayanand University (MDU), Rohtak-124001 (Haryana), India.
    Protein-protein interaction (PPI) network analysis is a powerful strategy to understand M. tuberculosis (Mtb) system level physiology in the identification of hub proteins. In the present study, the PPI network of 79 Mtb toxin-antitoxin (TA) systems comprising of 167 nodes and 234 edges was investigated. Read More

    Insights from the Molecular dynamics simulation of BcsD Subunit from K. xylinus.
    Bioinformation 2017 30;13(11):376-379. Epub 2017 Nov 30.
    Centre for Computational Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda - 151001, India.
    Biofilms are bacteria living in micro-colonies with a protective coating in sessile form. The biofilm protects bacteria from harsh surroundings as well as help in antibiotics resistance using a semi-fluid substance. Cellulose is the major component of biofilm, which provides the sticky appearance to bacteria for attaching to the substratum. Read More

    In Silico Validation of D7 Salivary Protein-derived B- and T-cell Epitopes of Aedes aegypti as Potential Vaccine to Prevent Transmission of Flaviviruses and Togaviruses to Humans.
    Bioinformation 2017 30;13(11):366-375. Epub 2017 Nov 30.
    Sri Sakthi Amma Institute of Biomedical Research, Sri Narayani Hospital and Research Centre, Sripuram, Vellore - 632055, Tamil Nadu, India.
    Mosquito (Aedes aegyptii) salivary proteins play a crucial role in facilitating viral transmission from vector-to-host due to their role in facilitating the "blood meal" of the vector. Three main proteins, D7, aegyptin and Sialokinin play a role in this process. Using in-silico programs, we identified B- and T-cell epitopes in the mosquito salivary proteins D7 long and short form. Read More

    Ymr210wp leads to the accumulation of phospholipids and steryl esters in yeast.
    Bioinformation 2017 30;13(11):360-365. Epub 2017 Nov 30.
    Department of Biotechnology, K L University, Green fields, Vaddeswaram, Guntur Dist, Andhra Pradesh, India - 522502.
    Ymr210w was identified as a MAG (Monoacylglycerol) lipase. The accumulation of the phospholipids in the ymr210wΔ was not clearly understood. It was expressed in S. Read More

    Molecular docking analysis of curcumin analogues with COX-2.
    Bioinformation 2017 30;13(11):356-359. Epub 2017 Nov 30.
    Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Jl. Sekip Utara, Yogyakarta 55281, Indonesia.
    Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. The designed analogues significantly enhance COX-2 selectivity. The three compounds could dock into the active site of COX-2 successfully. Read More

    Clinical Immunology of Cholera - Current Trends and Directions for Future Advancement.
    Bioinformation 2017 31;13(10):352-355. Epub 2017 Oct 31.
    Laboratory of Human Psychoneuroendocrine-Osteoimmunology; School of Dentistry, UCLA Center for the Health Sciences, Los Angeles, CA 90095-1668.
    Cholera remains a feared, aggressive, infectious and lethal disease today, despite several decades of intense research, concerted public health modalities designed to prevent, and to control outbreaks, availability of efficacious vaccines aimed at containing its contagious spread, and effective patient-centered medical interventions for reducing morbidity and mortality. Despite these advances, cholera still strikes communities around the world, especially in countries and regions of the globe where medical and nursing care cannot be as effectively proffered to the population at risk as in First World economies. Case in point, the number of suspected cholera cases that currently afflicts Yemen escalates at an "unprecedented rate", according to the World Health Organization. Read More

    Cholera host response gene networks: preliminary studies.
    Bioinformation 2017 31;13(10):347-351. Epub 2017 Oct 31.
    Division of Infectious Diseases and International Medicine, Department of Internal Medicine, Morsani College of Medicine, Tampa, FL 33606 USA.
    Gene network analysis was performed based on published literature describing genes that are possibly interconnected with cholera vaccine responses in vitro in cell culture and in vivo in human patient punch biopsies as well as DNA extracted from blood. These studies produced divergent results. The differences should be replicated and studied further. Read More

    Lubricin: A Principal Modulator of the Psychoneuroendocrine - Osteoimmune Interactome - Implications for Novel Treatments of Osteoarthritic Pathologies.
    Bioinformation 2017 31;13(10):343-346. Epub 2017 Oct 31.
    Laboratory of Human Psychoneuroendocrine-Osteoimmunology; School of Dentistry, UCLA Center for the Health Sciences, Los Angeles, CA 90095-1668.
    Lubricin is a synovial glycoprotein that contributes to joint lubrication. We propose the hypothesis that lubricin is a key modulator of the psychoneuroendocrine-osteoimmune interactome, with important clinical relevance for osteoarthritic pathologies. We consider a variety of neuroendocrine-immune factors, including inflammatory cytokines and chemokines that may contribute to the modulation of lubricin in rheumatic complications. Read More

    A QSAR model of Olanzapine derivatives as potential inhibitors for 5-HT2A Receptor.
    Bioinformation 2017 31;13(10):339-342. Epub 2017 Oct 31.
    Department of Biotechnology, Rama University Uttar Pradesh, Kanpur, India.
    Schizophrenia is a complex, chronic mental disorder, affecting about 21 million people worldwide. It is characterized by symptoms, including distortions in thinking, perception, emotions, disorganized speech, sense of self and behavior. Recently, a numbers of marketed drugs for Schizophrenia are available against dopamine D2 and serotonin 5-HT2A receptors. Read More

    Host Infection beyond the Traditional Range of Sclerotium (Athelia) rolfsii with Physalis minima.
    Bioinformation 2017 31;13(10):333-338. Epub 2017 Oct 31.
    AICRP on Vegetable crops, Directorate of Research, B.C.K.V, Kalyani, Nadia, West Bengal, India.
    Physalis minima is an herbaceous plant and inhabitant of the porous and organic matter containing soil of bunds in crop fields, wastelands, around the houses, and on the roadsides. S. rolfsii is soil borne and it can infect over 500 plant species of different families. Read More

    Robust Feature Selection Approach for Patient Classification using Gene Expression Data.
    Bioinformation 2017 31;13(10):327-332. Epub 2017 Oct 31.
    Bioinformatics Lab, Department of Statistics, University of Rajshahi-6205, Bangladesh.
    Patient classification through feature selection (FS) based on gene expression data (GED) has already become popular to the research communities. T-test is the well-known statistical FS method in GED analysis. However, it produces higher false positives and lower accuracies for small sample sizes or in presence of outliers. Read More

    Molecular modeling and simulation of three important components of Plant Pathogen Interaction cascade in Vigna mungo.
    Bioinformation 2017 31;13(10):323-326. Epub 2017 Oct 31.
    Division of Plant Biology, Bose Institute, Kolkata-700054.
    Plant pathogen interaction plays a great role in plant immunity. The regulation of various components of plant pathogen interactions is quite complicated and is very important in establishing relationship among components of this system. Yellow Mosaic Disease is common among legumes such as Vigna mungo. Read More

    Insights from the analysis of alginate lyase protein model from Pseudomonas fluorescens towards the understanding of mucoid biofilm disruption.
    Bioinformation 2017 30;13(9):318-322. Epub 2017 Sep 30.
    Centre for Computational Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda 151001, India.
    Bacterial biofilm is a protective, slippery and slimy coat secreted by bacterial cells. It helps in attaching to moisturized surfaces during colonization. Alginate is an important component as it is essential for retention of water and nutrients in biofilms. Read More

    Use of a neural network to predict normalized signal strengths from a DNA-sequencing microarray.
    Bioinformation 2017 30;13(9):313-317. Epub 2017 Sep 30.
    Department of Computer Science.
    A microarray DNA sequencing experiment for a molecule of N bases produces a 4xN data matrix, where for each of the N positions each quartet comprises the signal strength of binding of an experimental DNA to a reference oligonucleotide affixed to the microarray, for the four possible bases (A, C, G, or T). The strongest signal in each quartet should result from a perfect complementary match between experimental and reference DNA sequence, and therefore indicate the correct base call at that position. The linear series of calls should constitute the DNA sequence. Read More

    Analysis of predicted B and T-cell epitopes in Der p 23, allergen from Dermatophagoides pteronyssinus.
    Bioinformation 2017 30;13(9):307-312. Epub 2017 Sep 30.
    Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences-International Campus (IC-TUMS) Tehran, Iran.
    House dust mite (HDM) allergy is the leading cause of IgE-mediated hypersensitivity. Therefore identifying potential epitopes in the Dermatophagoide pteronyssinus 23 (Der p 23), a major house dust mite allergen will aid in the development of therapeutic vaccines and diagnostic kits for HDM allergy. Experimental methods of epitope discovery have been widely exploited for the mapping of potential allergens. Read More

    Prediction aided in vitro analysis of octa-decanoic acid from Cyanobacterium Lyngbya sp. as a proapoptotic factor in eliciting anti-inflammatory properties.
    Bioinformation 2017 30;13(9):301-306. Epub 2017 Sep 30.
    Department of Microbiology, Bharathidasan University, Tiruchirappalli - 620024, Tamilnadu, India.
    Marine Lyngbya has been proven as a potent anticancer agent by disrupting microfilament network. Lyngbya and its associated cyanobacterial compounds have been stressed for futuristic advancements in cancer research and have foreseen explicit advancements in the recent era. Moreover, compounds like lyngbyabellins, lyngbyastatins and other derived toxins are significantly studied. Read More

    Molecular docking analysis of aplysin analogs targeting survivin protein.
    Bioinformation 2017 30;13(9):293-300. Epub 2017 Sep 30.
    Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow, Uttar Pradesh, India-226026.
    Survivin (IAP proteins) remains an important target for anticancer drug development as it is reported to be over-expressed in tumor cells to enhance resistance to apoptotic stimuli. The study focuses on virtual screening of marine compounds inhibiting survivin, a multifunctional protein, using a computational approach. Structures of compounds were prepared using ChemDraw Ultra 10. Read More

    Molecular docking based screening of triterpenoids as potential G-quadruplex stabilizing ligands with anti-cancer activity.
    Bioinformation 2017 30;13(9):284-292. Epub 2017 Sep 30.
    Department of Pharmacology, Faculty of Science, Mahidol University, 272 Rama 6 Road, Bangkok 10400, Thailand.
    Triterpenoids isolated from Ganoderma lucidum (GLTs) exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic activities. Current research studies revealed the role by GLTs in inducing apoptosis and suppression of telomerase activity of cancer cells with much lower toxicity to healthy cells. Compounds selectively binding and stabilizing G-quadruplex structures could inhibit the telomerase or downregulate the oncogenes and may act as anti-cancer agents. Read More

    Molecular dynamics simulation analysis of Focal Adhesive Kinase (FAK) docked with solanesol as an anti-cancer agent.
    Bioinformation 2017 30;13(9):274-283. Epub 2017 Sep 30.
    Durga Femto Technologies and Research, Bangalore 560018, Karnataka, India.
    Focal adhesion kinase (FAK) plays a primary role in regulating the activity of many signaling molecules. Increased FAK expression has been associated in a series of cellular processes like cell migration and survival. FAK inhibition by an anti cancer agent is critical. Read More

    Potential Hemoglobin A/F role in clinical Malaria.
    Bioinformation 2017 31;13(8):269-273. Epub 2017 Aug 31.
    Immunology Division, ICMR-National Institute of Malaria Research, Dwarka, New Delhi; Present Address: Regional Medical Research Centre, Belagavi, Nehru Nagar, National Highway No.4, Belagavi-590010, Karnataka, India.
    The Malarial parasite resides in the host RBC during its erythrocytic cycle. Plasmodium meets its entire nutritional requirement from RBC. It scavenges the hemoglobin of RBCs to meet its amino acid requirement. Read More

    Druggability and Binding Site Interaction Studies of Potential Metabolites Isolated from Marine Sponge Aurora globostellata against Human Epidermal Growth Factor Receptor-2.
    Bioinformation 2017 31;13(8):261-268. Epub 2017 Aug 31.
    Centre for Drug Discovery and Development, Jeppiaar Research park, Sathyabama University, Chennai 600119,Tamilnadu, India.
    To study the involvement of compounds stigmasterol and oleic acid isolated from marine sponge Aurora globostellata and docking against the Human Epidermal Growth Factor Receptor-2 in breast cancer. The comparative molecular docking was performed with the natural compounds from marine sponge and the synthetic drugs used in breast cancer treatment against the target HER2. The molecular docking analysis was done using GLIDE in Schrodinger software package. Read More

    Marine sponge derived natural products as inhibitors of mycothiol-S-conjugate amidase.
    Bioinformation 2017 31;13(8):256-260. Epub 2017 Aug 31.
    School of Biotechnology, IFTM University, Lodhipur Rajput, Delhi Road, Moradabad 244001, U.P., India.
    Marine sponges have potential sources for secondary metabolites and are considered as a drug treasure house. In this work, 3D model of Mycothiol-S-conjugate amidase (Mca) was determined by comparative homology modeling program MODELLER based on the crystal structure of 1-D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis as a template. The computed model's energy was minimized and validated to obtain a stable model structure. Read More

    Identification of long non-coding RNA in rice lines resistant to Rice blast pathogen Maganaporthe oryzae.
    Bioinformation 2017 31;13(8):249-255. Epub 2017 Aug 31.
    ICAR-National Research Centre on Plant Biotechnology, Pusa Campus, New Delhi-110012, India.
    Rice blast disease caused by a fungus Magnaporthae oryzae is one of the most important biotic factors that severely damage the rice crop. Several molecular approaches are now being applied to tackle this issue in rice. It is of interest to study long non-coding RNA (lncRNA) in rice to control the disease. Read More

    Naturally occurring capsid protein variants L1 of human papillomavirus genotype 16 in Morocco.
    Bioinformation 2017 31;13(8):241-248. Epub 2017 Aug 31.
    Unit of Biology and Medical Research, National Centre Natuional de l´Energie, des Sciences et des techniques Nucléaires. Morocco.
    HPV L1 protein is a corner stone in HPV structure, it's involved in the formation of the viral capsid; widely used as a systematic material and considered as the main component in vaccines development and production. The present study aims to characterize genetic variation of L1 gene of HPV 16 specimens and to evaluate in silico the impact of major variants on the epitope change affecting its conformational structure. A fragment of L1 gene from 35 HPV 16 confirmed specimens were amplified by PCR and sequenced. Read More

    Docking analysis of verteporfin with YAP WW domain.
    Bioinformation 2017 31;13(7):237-240. Epub 2017 Jul 31.
    Laboratoire de Biotechnologie (MedBiotech), Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V Rabat, Morocco.
    The YAP oncogene is a known cancer target. Therefore, it is of interest to understand the molecular docking interaction of verteporfin (a derivative of benzo-porphyrin) with the WW domain of YAP (clinically used for photo-dynamic therapy in macular degeneration) as a potential WW domain-ligand modulator by inhibition. A homology protein SWISS MODEL of the human YAP protein was constructed to dock (using AutoDock vina) with the PubChem verteporfin structure for interaction analysis. Read More

    Short peptide epitope design from hantaviruses causing HFRS.
    Bioinformation 2017 31;13(7):231-236. Epub 2017 Jul 31.
    Sri Sakthi Amma Institute of Biomedical Research, Sri Narayani Hospital and Research Centre, Sripuram, Vellore 632 055, Tamil Nadu, India.
    Several genotypes of the hantavirus cause hemorrhagic fever with renal syndrome (HFRS) and is an important public health problem worldwide. There is now growing interest to develop subunit vaccines especially focused to elicit cytotoxic T lymphocyte responses which are important against viral infection. We identified candidate T-cell epitopes that bind to Class I HLA supertypes towards identifying potential subunit vaccine entity. Read More

    A Genomic Signature for Genotyping Mycobacterium tuberculosis.
    Bioinformation 2017 31;13(7):224-230. Epub 2017 Jul 31.
    Laboratorio de Biotecnología y Biología Molecular, Centro Nacional de Salud Pública, Instituto Nacional de Salud, Lima, Perú.
    Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB), has a vast diversity of genotypes including Beijing, CAS, EAI, Haarlem, LAM, X, Ural, T, AFRI1 and AFRI2. However, genotyping can be expensive, time consuming and in some cases, results may vary depending on methodology used. Here, we proposed a new set of 10 SNPs using a total of 249 MTB genomes, and selected by first the inclusion/ exclusion (IE) criteria using spoligotyping and phylogenies, followed by the selection of the nonsynonymous SNPs present in the most conserved cluster of orthologous groups (COG) of each genotype of MTB. Read More

    Designing Epitope Ensemble Vaccines against TB by Selection: Prioritizing Antigens using Predicted Immunogenicity.
    Bioinformation 2017 31;13(7):220-223. Epub 2017 Jul 31.
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom, B4 7ET.
    Tuberculosis (TB) is a global health burden, and a major cause of mortality and morbidity in West Africa. Here, we select key conserved pathogen epitopes of proven immunogenicity to form a potential TB epitope ensemble vaccine. We compared two vaccine formulations: one comprising class I epitopes from the 13 most prevalent class I epitope-bearing antigens and class II epitopes deriving from the 20 most prevalent class II epitope-bearing antigens and another consisting of epitopes derived solely from 5 antigens identified as the most immunogenic by VaxiJen. Read More

    Meta-analysis study to evaluate the association of MTHFR C677T polymorphism with risk of ischemic stroke.
    Bioinformation 2017 30;13(6):214-219. Epub 2017 Jun 30.
    Department of Bioinformatics, Sri Ramachandra University, Porur, Chennai-600 116, India.
    Ischemic stroke is a condition characterized by reduced blood supply to part of the brain, initiating the ischemic cascade, leading to dysfunction of the brain tissue in that area. It is one of the leading causes of death and disability and is estimated to cause around 5.7 million deaths worldwide. Read More

    Deciphering the Role of microRNAs in BRD4-NUT Fusion Gene Induced NUT Midline Carcinoma.
    Bioinformation 2017 30;13(6):209-213. Epub 2017 Jun 30.
    Bioinformatics Department, MMV, Banaras Hindu University, India.
    NUT midline carcinoma (NMC) is a very aggressive and lethal type of squamous epithelial cell cancer caused due to fusion of BRD4 and NUT genes. The gene fusion results into a new fusion protein that promotes oncogenesis. The detailed molecular mechanisms underlying the NMC are still not clear and new findings are urgently required to complement the current efforts. Read More

    Serum and Plasma Metabolomic Biomarkers for Lung Cancer.
    Bioinformation 2017 30;13(6):202-208. Epub 2017 Jun 30.
    Bioinformatics Lab, Department of Statistics, Rajshahi University, Rajshahi, Bangladesh.
    In drug invention and early disease prediction of lung cancer, metabolomic biomarker detection is very important. Mortality rate can be decreased, if cancer is predicted at the earlier stage. Recent diagnostic techniques for lung cancer are not prognosis diagnostic techniques. Read More

    Combination of bone marrow mesenchymal stem cells and cartilage fragments contribute to enhanced repair of osteochondral defects.
    Bioinformation 2017 30;13(6):196-201. Epub 2017 Jun 30.
    Department of Orthopaedic Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
    Cartilage tissue engineering using stem cells and biomaterials is considered a promising approach despite poor outcomes. We hypothesise that articular cartilage fragments provides native environmental cues to enhance stem cell differentiation. As such we evaluated the chondrogenic differentiation and repair of critical size defect in a human explant osteochondral model (OD) using bone marrow derived mesenchymal stem cells (BM-MSCs) and homogenised cartilage. Read More

    Designing of a penta-peptide against drug resistant E. coli.
    Bioinformation 2017 30;13(6):192-195. Epub 2017 Jun 30.
    Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, haryana 133207.
    Drug resistant pathogens are vibrant global problem. Penicillin binding protein 5 (PBP5) plays important role in bacterial cell wall biosynthesis. Mutation in PBP5 is a well-known mechanism for development of drug resistant strain of bacteria. Read More

    Structural insight into the binding of C60-derivatives with enoyl-pyruvate transferase from Helicobacter pylori.
    Bioinformation 2017 30;13(6):185-191. Epub 2017 Jun 30.
    Department of Biochemistry, Huazhong University of science and Technology, China.
    Helicobacter pylori (H. pylori) is a human pathogen associated with acute gastritis and peptic ulcer. The MurA enzyme is an important drug target for the identification of ligands with improved efficacy and acceptable pharmaco-kinetic properties. Read More

    Transcriptome wide identification and characterization of starch branching enzyme in finger millet.
    Bioinformation 2017 30;13(6):179-184. Epub 2017 Jun 30.
    Uttarakhand Technical University, Dehradun, Uttarakhand, 248007, India.
    Starch-branching enzymes (SBEs) are one of the four major enzyme classes involved in starch biosynthesis in plants and play an important role in determining the structure and physical properties of starch granules. Multiple SBEs are involved in starch biosynthesis in plants. Finger millet is calcium rich important serial crop belongs to grass family and the transcriptome data of developing spikes is available on NCBI. Read More

    Analysis of correlated mutations in Ras G-domain.
    Bioinformation 2017 30;13(6):174-178. Epub 2017 Jun 30.
    Bioinformatics Department, MMV, Banaras Hindu University.
    Ras GTPases are most prevalent proto-oncogenes in human cancer. Mutations in Ras remain untreatable more than three decades after the initial discovery. At the amino acid level, some residues under physical or functional constraints exhibit correlated mutations also known as coevolving/covariant residues. Read More

    Protein-protein interfaces are vdW dominant with selective H-bonds and (or) electrostatics towards broad functional specificity.
    Bioinformation 2017 30;13(6):164-173. Epub 2017 Jun 30.
    Biomedical Informatics (P) Ltd, Irulan Sandy Annex, Puducherry 607 402, India.
    Several catalysis, cellular regulation, immune function, cell wall assembly, transport, signaling and inhibition occur through Protein- Protein Interactions (PPI). This is possible with the formation of specific yet stable protein-protein interfaces. Therefore, it is of interest to understand its molecular principles using structural data in relation to known function. Read More

    Molecular docking based screening of Listeriolysin-O for improved inhibitors.
    Bioinformation 2017 31;13(5):160-163. Epub 2017 May 31.
    Vira Vigene research institute, Tehran, Iran.
    Listeriolysine-O (LLO) is a 50KDa protein responsible for Listeria monocytogenes pathogenicity. The structure of LLO (PDB ID: 4CDB) with domains D1 to D4 is known. Therefore, it is of interest to identify conserved regions among LLO variants for destabilizing oligomerization (50 mer complex) of its monomers using appropriate inhibitors. Read More

    QSAR based predictive modeling for anti-malarial molecules.
    Bioinformation 2017 31;13(5):154-159. Epub 2017 May 31.
    School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-67.
    Malaria is a predominant infectious disease, with a global footprint, but especially severe in developing countries in the African subcontinent. In recent years, drug-resistant malaria has become an alarming factor, and hence the requirement of new and improved drugs is more crucial than ever before. One of the promising locations for antimalarial drug target is the apicoplast, as this organelle does not occur in humans. Read More

    Polymorphism of the PAI-1gene (4G/5G) may be linked with Polycystic Ovary Syndrome and associated pregnancy disorders in South Indian Women.
    Bioinformation 2017 31;13(5):149-153. Epub 2017 May 31.
    Genes N Life Healthcare, Hyderabad.
    Polycystic Ovary syndrome (PCOS) is the most common endocrine disorder affecting 5 - 10% of all women of reproductive age group. The present research was carried out to study the impact of Plasminogen Activator Inhibitor (PAI-1) 4G/5G polymorphism (rs1799889) in PCOS, and the risk of developing PCOS in South Indian Population. The study was carried out in 60 subjects of South Indian population (30 PCOS and 30 Non PCOS) recruited from ARC Research and Fertility Centre, Chennai, India. Read More

    1 OF 31