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    1 OF 31

    Scale-free networks in metabolomics.
    Bioinformation 2018 31;14(3):140-144. Epub 2018 Mar 31.
    Neonatal Intensive Care Unit, Department of Surgical Sciences, Neonatal Pathology and Neonatal Section, University of Cagliari, Cagliari, Italy.
    Metabolomics is an expanding discipline in biology. It is the process of portraying the phenotype of a cell, tissue or species organism using a comprehensive set of metabolites. Therefore, it is of interest to understand complex systems such as metabolomics using a scale-free topology. Read More

    Insights from the Molecular Modelling and Docking Analysis of AIF-NLS complex to infer Nuclear Translocation of the Protein.
    Bioinformation 2018 31;14(3):132-139. Epub 2018 Mar 31.
    Department of Genetic Engineering, School of Bioengineering, SRM University, Kattankulathur, Chennai - 603203.
    Apoptosis Inducing Factor protein has a dual role depending on its localization in mitochondrion (energy production) and nucleus (induces apoptosis). Cell damage transports this protein to nucleus which otherwise favors mitochondrion. The alteration of Nuclear Localisation Signal tags could aid nuclear translocation. Read More

    Identification of cis-regulatory elements associated with salinity and drought stress tolerance in rice from co-expressed gene interaction networks.
    Bioinformation 2018 31;14(3):123-131. Epub 2018 Mar 31.
    National Research Centre on Plant Biotechnology, Indian Agriculture Research Institute, New Delhi, India.
    Rice, a staple food crop, is often subjected to drought and salinity stresses thereby limiting its yield potential. Since there is a cross talk between these abiotic stresses, identification of common and/or overlapping regulatory elements is pivotal for generating rice cultivars that showed tolerance towards them. Analysis of the gene interaction network (GIN) facilitates identifying the role of individual genes and their interactions with others that constitute important molecular determinants in sensing and signaling cascade governing drought and/or salinity stresses. Read More

    Analysis of antibiotics resistant genes in different strains of .
    Bioinformation 2018 31;14(3):113-122. Epub 2018 Mar 31.
    Cellular Parasitology Programme, Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria.
    The control of Staphylococcus aureus infection is being hampered by methicillin and other resistant strains. The identification of the unique antibiotic resistant genes from the genomes of various strains of S. aureus is of interest. Read More

    Genetic characterization of Chikungunya virus 2009 isolates from South India.
    Bioinformation 2018 31;14(3):106-112. Epub 2018 Mar 31.
    Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, India.
    Chikungunya Virus (CHIKV) is a single stranded positive sense enveloped RNA virus. Re-emergence of CHIKV caused a massive outbreak with severe clinical manifestation affecting multiple organs. The genetic diversity of CHIKV, which caused recurring outbreaks in India, was studied. Read More

    Molecular dynamics simulation (MDS) analysis of ToxT virulence factor complexed with docked potential inhibitors.
    Bioinformation 2018 31;14(3):101-105. Epub 2018 Mar 31.
    Molecular Biology Research Center, Systems Biology and Poisonings institute, Baqiyatallah University of Medical Sciences, Tehran, IRAN.
    The ToxT transcription factor mediates the transcription of the two major virulence factors in Vibrio cholerae. It has a DNA binding domain made of α4, α5, α6, α7, α8, α9 and α10 helices that is responsible for the transcription of virulence genes. Therefore, it is of interest to screen ToxT against the ZINC ligand database containing data for a million compounds. Read More

    physicochemical characterization and topology analysis of Respiratory burst oxidase homolog (Rboh) proteins from Arabidopsis and rice.
    Bioinformation 2018 31;14(3):93-100. Epub 2018 Mar 31.
    Department of Biotechnology, Guru Nanak Dev University (GNDU), Amritsar 143005, Punjab, India.
    NADPH oxidase (NOX) is a key enzyme involved in the production of apoplastic superoxide (O2-), a type of reactive oxygen species (ROS). Plant Noxes are the homologs of mammalian NADPH oxidase's catalytic subunit and are documented as respiratory burst oxidase homologs (Rbohs). A number of studies have reported their diverse functions in combating various stresses and in plant growth and development. Read More

    Quantitative Consensus in Systematic Reviews: Current and Future Challenges in Translational Science.
    Bioinformation 2018 28;14(2):86-92. Epub 2018 Feb 28.
    Laboratory of Human Psychoneuroendocrine-Osteoimmunology; School of Dentistry, UCLA Center for the Health Sciences, Los Angeles, CA 90095-1668.
    Translational science conceptualizes healthcare as a concerted set of processes that integrate research findings from the bench to the bedside. This model of healthcare is effectiveness-focused, patient-centered, and evidence-based, and yields evidence-based revisions of practice-based guidelines, which emerge from research synthesis protocols in comparative effectiveness research that are disseminated in systematic reviews. Systematic reviews produce qualitative and quantitative consensi of the best available evidence. Read More

    Current Opinions on Chemoresistance: An Overview.
    Bioinformation 2018 28;14(2):80-85. Epub 2018 Feb 28.
    Medical Oncology Department, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
    Sub population of cancer cells, referred to as Cancer stem cells (CSCs) or tumor initiating cells, have enhanced metastatic potential that drives tumor progression. CSCs have been found to hold intrinsic resistance to present chemotherapeutic strategies. This resistance is attributed to DNA reparability, slower cell cycle and high levels of detoxifying enzymes. Read More

    Simian Virus 40 Large T Antigen as a Model to Test the Efficacy of Flouroquinolones against Viral Helicases.
    Bioinformation 2018 28;14(2):75-79. Epub 2018 Feb 28.
    Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan.
    Simian virus 40 large T-antigen (SV40 LT-Ag) is a 708 amino acid nuclear phosphoprotein. Among many functions of LT-Ag is its ability to perform as an ATPase-helicase, catalyzing the unwinding of viral genome during replication. The LT-Ag has been employed in the studies of helicase structure and function, and has served as a model helicase for the screening of antiviral drugs that target viral helicase. Read More

    Screening of Human Proteins for Fluoride and Aluminum Binding.
    Bioinformation 2018 28;14(2):68-74. Epub 2018 Feb 28.
    Department of Biological Sciences, St. John's University, Queens, New York 11439.
    Previous studies showed that prolonged exposure to fluoride (F-) and aluminum (Al3+) ions is associated with numerous diseases including neurological disorders. They don't have any known biological function. But they can bind with proteins that interact with ions similar to them. Read More

    flavanones; apposite inverse agonists of the β2-adrenergic receptor in asthma treatment.
    Bioinformation 2018 28;14(2):60-67. Epub 2018 Feb 28.
    Department of Chemical Sciences, Adekunle Ajasin University, Akungba Akoko, Ondo State, Nigeria.
    Asthma is an inflammatory disease of the airway that poses a major threat to human health. With increase industrialization in the developed and developing countries, the incidence of asthma is on the rise. The β2-adrenergic receptor is an important target in designing anti-asthmatic drugs. Read More

    Evaluation of in vitro chondrocytic differentiation: A stem cell research initiative at the King Abdulaziz University, Kingdom of Saudi Arabia.
    Bioinformation 2018 28;14(2):53-59. Epub 2018 Feb 28.
    Stem Cell Unit, Centre of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
    Mesenchymal stem cells (MSCs) from various sources have been used in cartilage differentiation with variable success. Therefore, it is of interest to evaluate the in vitro differentiation potential of the hWJSCs derived from the human umbilical cords into chondrocytes at the stem cell research facility at the King Abdulaziz University. hWJSCs are an attractive choice for tissue engineering and regenerative medical applications including cartilage regeneration. Read More

    Hypothetical endogenous SIV-like antigens in Mauritian cynomolgus macaques.
    Bioinformation 2018 28;14(2):48-52. Epub 2018 Feb 28.
    Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
    Simian immunodeficiency virus (SIV) infection of Mauritian cynomolgus macaques (MCMs) is an increasingly important nonhuman primate model for HIV vaccine research. We previously reported that in MCMs anti-SIV antibodies can be naturally developed without exogenous infection or vaccination, and that a vaccine targeting SIV protease cleavage sites (PCS) can cross-induce antibodies to non-PCS SIV antigens. We speculate that this is potentially caused by the existence of endogenous SIV-like antigens. Read More

    An Integrated Molecular Database on Indian Insects.
    Bioinformation 2018 28;14(2):42-47. Epub 2018 Feb 28.
    ICAR-Indian Agricultural Statistical, Research Institute, New Delhi - 110 012, India.
    MOlecular Database on Indian Insects (MODII) is an online database linking several databases like Insect Pest Info, Insect Barcode Information System (IBIn), Insect Whole Genome sequence, Other Genomic Resources of National Bureau of Agricultural Insect Resources (NBAIR), Whole Genome sequencing of Honey bee viruses, Insecticide resistance gene database and Genomic tools. This database was developed with a holistic approach for collecting information about phenomic and genomic information of agriculturally important insects. This insect resource database is available online for free at http://cib. Read More

    Artificial Intelligence and brain.
    Bioinformation 2018 31;14(1):38-41. Epub 2018 Jan 31.
    Division of Infectious Diseases and International Health, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL 33606, USA.
    From the start, Kurt Godel observed that computer and brain paradigms were considered on a par by researchers and that researchers had misunderstood his theorems. He hailed with displeasure that the brain transcends computers. In this brief article, we point out that Artificial Intelligence (AI) comprises multitudes of human-made methodologies, systems, and languages, and implemented with computer technology. Read More

    Odorant Binding Proteins: a key player in the sense of smell.
    Bioinformation 2018 31;14(1):36-37. Epub 2018 Jan 31.
    Centre for Pheromone Technology (CPT), Department of Animal Science, Bharathidasan University, Tiruchirappalli- 620 024. TN, India.
    Olfaction is an important mechanism by which humans and animals communicate with environment. Odorant-binding proteins (OBPs) play crucial role in the olfactory mechanism. Here, we briefly discuss about the role of OBPs and their importance in industrial, pest management and therapeutic developments. Read More

    Current Bioinformatics resources in combating infectious diseases.
    Bioinformation 2018 31;14(1):31-35. Epub 2018 Jan 31.
    Genetics and Biotechnology Department, Strategic Center for Diabetes Research, College of medicine, King Saud University, KSA.
    Bioinformatics tools and techniques analyzing next-generation sequencing (NGS) data are increasingly used for the diagnosis and monitoring of infectious diseases. It is of interest to review the application of bioinformatics tools, commonly used databases and NGS data in clinical microbiology, focusing on molecular identification, genotypic, microbiome research, antimicrobial resistance analysis and detection of unknown disease-associated pathogens in clinical specimens. This review documents available bioinformatics resources and databases that are used by medical microbiology scientists and physicians to control emerging infectious pathogens. Read More

    Identification and characterization of sodium and chloride-dependent gamma-aminobutyric acid (GABA) transporters from eukaryotic pathogens as a potential drug target.
    Bioinformation 2018 31;14(1):21-30. Epub 2018 Jan 31.
    Nigeria Cellular Parasitology Programme, Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria.
    We explored 285 completed eukaryotic pathogen genomes for GABA transporter proteins as effective chemotherapy targets. We identified 8 GABA proteins that spread across 4 phyla with 5 different pathogen species; Eimeria mitis Houghton, Neospora caninum Liverpool, S. mansoni, S. Read More

    Molecular docking based screening of Noggin inhibitors.
    Bioinformation 2018 31;14(1):15-20. Epub 2018 Jan 31.
    Department of Botany, Bioinformatics and Climate Change Impacts Management, School of Sciences, Gujarat University, Ahmedabad 300019, India.
    Noggin (NOG) a BMP (bone morphogenetic protein) antagonist plays a key role in preferentially driving a subset of breast cancer cells towards the bone and causing osteolytic lesions leading to severe pain and discomfort in the patients. Owing to its role in bone metastasis, NOG could be promising molecular target in bone metastasis and that identifying small molecule inhibitors could aid in the treatment. Towards identifying cognate inhibitors of NOG, structure based virtual screen was employed. Read More

    Identification of coding sequence and its use for functional and structural characterization of catalase from .
    Bioinformation 2018 31;14(1):8-14. Epub 2018 Jan 31.
    Department of Botany, Faculty of Life Sciences, Maharshi Dayanand University, Rohtak-124001, India.
    Catalase is an essential antioxidant enzyme that is well characterized from microbial and animal sources. The structure of plant catalase is unknown. Therefore, it is of interest to understand the functional and structural characteristics of catalase from an Indian gooseberry, Phyllanthus emblica (or Emblica officinalis). Read More

    Towards the design of anti-amyloid short peptide helices.
    Bioinformation 2018 31;14(1):1-7. Epub 2018 Jan 31.
    Chair of Medical Biochemistry, Jagiellonian University-Medical College, Kopernika 7, 31-034 Krakow, Poland.
    A set of short peptide sequences susceptible to fibrillar aggregation produces sequneces capable of arresting elongation of amyloid fibrils. The "stop" signals are short helices customized for each individual target. Such a helix should exhibit high amphiphilicity, with differing conditions present on each side (one side should be highly hydrophilic to enable water to interact with the aggregate, while the other side must retain a local distribution of hydrophobicity which matches that of the terminal portion of the fibril). Read More

    Characterization of a hypothetical protein YVRE from Bacillus subtilis indicates its key role as glucono-lactonase in pentose phosphate pathway and glucose metabolism.
    Bioinformation 2017 31;13(12):430-438. Epub 2017 Dec 31.
    Department of Biotechnology, Sir M Visvesvaraya Institute of Technology, Hunasemaranahalli, Bangalore 562157.
    Hypothetical proteins are functionally uncharacterized proteins with assigned function using sequence annotation tools. Almost half of the coding regions of several genomes are hypothetical proteins. Therefore, it is of our interest to characterize a hypothetical protein YVRE from the model system Bacillus subtilis using known data. Read More

    Computer aided epitope design as a peptide vaccine component against Lassa virus.
    Bioinformation 2017 31;13(12):417-429. Epub 2017 Dec 31.
    Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh.
    Lassa virus (LASV) is an arena virus causing hemorrhagic fever and it is endemic in several regions of West Africa. The disease-causing virus records high mortality rate in endemic regions due to lack of appropriate treatment and prevention strategies. Therefore, it is of interest to design and develop viable vaccine components against the virus. Read More

    Recent trends in antimicrobial peptide prediction using machine learning techniques.
    Bioinformation 2017 31;13(12):415-416. Epub 2017 Dec 31.
    Shiv Nadar University, Gautam Budha Nagar, U.P 201314.
    The importance to develop effective alternatives to known antibiotics due to increased microbial resistance is gaining momentum in recent years. Therefore, it is of interest to predict, design and computationally model Antimicrobial Peptides (AMPs). AMPs are oligopeptides with varying size (from 5 to over100 residues) having key role in innate immunity. Read More

    Telenursing: Bioinformation Cornerstone in Healthcare for the 21st Century.
    Bioinformation 2017 31;13(12):412-414. Epub 2017 Dec 31.
    Oral Biology & Medicine, School of Dentistry, Center for the Health Sciences University of California Los Angeles, USA.
    Bioinformation is at the very core of 21st-century healthcare. Telehealth consists of the range of healthcare-related services delivered through bioinformation-aided telecommunications across health-related disciplines, including nursing. Whereas it is clear that bedside patient-centered nursing can never be replaced, recent developments in bioinformation-aided telenursing will undoubtedly contribute to improving healthcare effectiveness and efficacy. Read More

    Artificial Intelligence and Virology - quo vadis.
    Bioinformation 2017 31;13(12):410-411. Epub 2017 Dec 31.
    Division of Infectious Diseases and International Health, Department of Internal Medicine, Tampa General Hospital, University of South Florida, Morsani College of Medicine, Tampa, FL 33606, USA.
    Artificial Intelligence (AI), robotics, co-robotics (cobots), quantum computers (QC), include surges of scientific endeavor to produce machines (mechanical and software) among numerous types and constructions that are accelerating progress to defeat infectious diseases. There is a plethora of additional applications and uses of these methodologies and technologies for the understanding of biomedicine through bioinformation discovery. Therefore, we briefly outline the use of such techniques in virology. Read More

    Current views and challenges on clinical cholera.
    Bioinformation 2017 31;13(12):405-409. Epub 2017 Dec 31.
    Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL 33606, USA.
    Cholera, an acute diarrheal infection has become a major global threat. Vibrio cholerae the causative agent of cholera has been responsible for six previous pandemics since 1817 that spanned four continents and Australia with the seventh pandemic ongoing since 1961. Two serogroups of V. Read More

    Current trends for customized biomedical software tools.
    Bioinformation 2017 31;13(12):402-404. Epub 2017 Dec 31.
    Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
    In the past, biomedical scientists were solely dependent on expensive commercial software packages for various applications. However, the advent of user-friendly programming languages and open source platforms has revolutionized the development of simple and efficient customized software tools for solving specific biomedical problems. Many of these tools are designed and developed by biomedical scientists independently or with the support of computer experts and often made freely available for the benefit of scientific community. Read More

    Antifreeze proteins.
    Bioinformation 2017 31;13(12):400-401. Epub 2017 Dec 31.
    Chair of Medical Biochemistry, Jagiellonian University - Medical College, Kopernika 7, 31-034 Krakow, Poland.
    The antifreeze protein (AFP) activity is explained using two models. The first model is using ice binding and the second is using antiice structuralization of water molecules. The description of AFP function using anti-ice structuralization of water molecules is less explored. Read More

    Current trends in small molecule discovery targeting key cellular signaling events towards the combined management of diabetes and obesity.
    Bioinformation 2017 31;13(12):394-399. Epub 2017 Dec 31.
    Department of Biotechnology, Anna University, Chennai Tamilnadu, India - 600 025.
    Non-insulin dependent diabetes mellitus, also known as Type 2 diabetes is a polygenic disorder leading to abnormalities in the carbohydrate and lipid metabolism. The major contributors in the pathophysiology of type 2 diabetes (T2D) include resistance to insulin action, β cell dysfunction, an abnormality in glucose metabolism and storage, visceral obesity and to some extent inflammation and oxidative stress. Insulin resistance, along with a defect in insulin secretion by the pancreatic β cells is instrumental towards progression to hyperglycemia. Read More

    Molecular docking based screening of a simulated HIF-1 protein model for potential inhibitors.
    Bioinformation 2017 30;13(11):388-393. Epub 2017 Nov 30.
    Centre for agricultural Bioinformatics, ICAR-IASRI (Indian Agricultural Statistics Research Institute), Library Avenue, Pusa, New Delhi - 110012, India.
    Hypoxia inducible factor-1(HIF-1) is a bHLH-family transcription factor that control genes involved in glucolysis, angiogenesis, migration, as well as invasion factors that are important for tumor progression and metastasis. HIF-1, a hetero dimer of HIF-1α and HIF-1β, binds to the hypoxia responsive genes, such as vascular endothelial growth factor (VEGF). It is one the molecular target for angiogenesis. Read More

    Insights from the protein-protein interaction network analysis of Mycobacterium tuberculosis toxin-antitoxin systems.
    Bioinformation 2017 30;13(11):380-387. Epub 2017 Nov 30.
    Centre for Biotechnology, Maharshi Dayanand University (MDU), Rohtak-124001 (Haryana), India.
    Protein-protein interaction (PPI) network analysis is a powerful strategy to understand M. tuberculosis (Mtb) system level physiology in the identification of hub proteins. In the present study, the PPI network of 79 Mtb toxin-antitoxin (TA) systems comprising of 167 nodes and 234 edges was investigated. Read More

    Insights from the Molecular dynamics simulation of BcsD Subunit from K. xylinus.
    Bioinformation 2017 30;13(11):376-379. Epub 2017 Nov 30.
    Centre for Computational Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda - 151001, India.
    Biofilms are bacteria living in micro-colonies with a protective coating in sessile form. The biofilm protects bacteria from harsh surroundings as well as help in antibiotics resistance using a semi-fluid substance. Cellulose is the major component of biofilm, which provides the sticky appearance to bacteria for attaching to the substratum. Read More

    In Silico Validation of D7 Salivary Protein-derived B- and T-cell Epitopes of Aedes aegypti as Potential Vaccine to Prevent Transmission of Flaviviruses and Togaviruses to Humans.
    Bioinformation 2017 30;13(11):366-375. Epub 2017 Nov 30.
    Sri Sakthi Amma Institute of Biomedical Research, Sri Narayani Hospital and Research Centre, Sripuram, Vellore - 632055, Tamil Nadu, India.
    Mosquito (Aedes aegyptii) salivary proteins play a crucial role in facilitating viral transmission from vector-to-host due to their role in facilitating the "blood meal" of the vector. Three main proteins, D7, aegyptin and Sialokinin play a role in this process. Using in-silico programs, we identified B- and T-cell epitopes in the mosquito salivary proteins D7 long and short form. Read More

    Ymr210wp leads to the accumulation of phospholipids and steryl esters in yeast.
    Bioinformation 2017 30;13(11):360-365. Epub 2017 Nov 30.
    Department of Biotechnology, K L University, Green fields, Vaddeswaram, Guntur Dist, Andhra Pradesh, India - 522502.
    Ymr210w was identified as a MAG (Monoacylglycerol) lipase. The accumulation of the phospholipids in the ymr210wΔ was not clearly understood. It was expressed in S. Read More

    Molecular docking analysis of curcumin analogues with COX-2.
    Bioinformation 2017 30;13(11):356-359. Epub 2017 Nov 30.
    Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Jl. Sekip Utara, Yogyakarta 55281, Indonesia.
    Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. The designed analogues significantly enhance COX-2 selectivity. The three compounds could dock into the active site of COX-2 successfully. Read More

    Clinical Immunology of Cholera - Current Trends and Directions for Future Advancement.
    Bioinformation 2017 31;13(10):352-355. Epub 2017 Oct 31.
    Laboratory of Human Psychoneuroendocrine-Osteoimmunology; School of Dentistry, UCLA Center for the Health Sciences, Los Angeles, CA 90095-1668.
    Cholera remains a feared, aggressive, infectious and lethal disease today, despite several decades of intense research, concerted public health modalities designed to prevent, and to control outbreaks, availability of efficacious vaccines aimed at containing its contagious spread, and effective patient-centered medical interventions for reducing morbidity and mortality. Despite these advances, cholera still strikes communities around the world, especially in countries and regions of the globe where medical and nursing care cannot be as effectively proffered to the population at risk as in First World economies. Case in point, the number of suspected cholera cases that currently afflicts Yemen escalates at an "unprecedented rate", according to the World Health Organization. Read More

    Cholera host response gene networks: preliminary studies.
    Bioinformation 2017 31;13(10):347-351. Epub 2017 Oct 31.
    Division of Infectious Diseases and International Medicine, Department of Internal Medicine, Morsani College of Medicine, Tampa, FL 33606 USA.
    Gene network analysis was performed based on published literature describing genes that are possibly interconnected with cholera vaccine responses in vitro in cell culture and in vivo in human patient punch biopsies as well as DNA extracted from blood. These studies produced divergent results. The differences should be replicated and studied further. Read More

    Lubricin: A Principal Modulator of the Psychoneuroendocrine - Osteoimmune Interactome - Implications for Novel Treatments of Osteoarthritic Pathologies.
    Bioinformation 2017 31;13(10):343-346. Epub 2017 Oct 31.
    Laboratory of Human Psychoneuroendocrine-Osteoimmunology; School of Dentistry, UCLA Center for the Health Sciences, Los Angeles, CA 90095-1668.
    Lubricin is a synovial glycoprotein that contributes to joint lubrication. We propose the hypothesis that lubricin is a key modulator of the psychoneuroendocrine-osteoimmune interactome, with important clinical relevance for osteoarthritic pathologies. We consider a variety of neuroendocrine-immune factors, including inflammatory cytokines and chemokines that may contribute to the modulation of lubricin in rheumatic complications. Read More

    A QSAR model of Olanzapine derivatives as potential inhibitors for 5-HT2A Receptor.
    Bioinformation 2017 31;13(10):339-342. Epub 2017 Oct 31.
    Department of Biotechnology, Rama University Uttar Pradesh, Kanpur, India.
    Schizophrenia is a complex, chronic mental disorder, affecting about 21 million people worldwide. It is characterized by symptoms, including distortions in thinking, perception, emotions, disorganized speech, sense of self and behavior. Recently, a numbers of marketed drugs for Schizophrenia are available against dopamine D2 and serotonin 5-HT2A receptors. Read More

    Host Infection beyond the Traditional Range of Sclerotium (Athelia) rolfsii with Physalis minima.
    Bioinformation 2017 31;13(10):333-338. Epub 2017 Oct 31.
    AICRP on Vegetable crops, Directorate of Research, B.C.K.V, Kalyani, Nadia, West Bengal, India.
    Physalis minima is an herbaceous plant and inhabitant of the porous and organic matter containing soil of bunds in crop fields, wastelands, around the houses, and on the roadsides. S. rolfsii is soil borne and it can infect over 500 plant species of different families. Read More

    Robust Feature Selection Approach for Patient Classification using Gene Expression Data.
    Bioinformation 2017 31;13(10):327-332. Epub 2017 Oct 31.
    Bioinformatics Lab, Department of Statistics, University of Rajshahi-6205, Bangladesh.
    Patient classification through feature selection (FS) based on gene expression data (GED) has already become popular to the research communities. T-test is the well-known statistical FS method in GED analysis. However, it produces higher false positives and lower accuracies for small sample sizes or in presence of outliers. Read More

    Molecular modeling and simulation of three important components of Plant Pathogen Interaction cascade in Vigna mungo.
    Bioinformation 2017 31;13(10):323-326. Epub 2017 Oct 31.
    Division of Plant Biology, Bose Institute, Kolkata-700054.
    Plant pathogen interaction plays a great role in plant immunity. The regulation of various components of plant pathogen interactions is quite complicated and is very important in establishing relationship among components of this system. Yellow Mosaic Disease is common among legumes such as Vigna mungo. Read More

    Insights from the analysis of alginate lyase protein model from Pseudomonas fluorescens towards the understanding of mucoid biofilm disruption.
    Bioinformation 2017 30;13(9):318-322. Epub 2017 Sep 30.
    Centre for Computational Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda 151001, India.
    Bacterial biofilm is a protective, slippery and slimy coat secreted by bacterial cells. It helps in attaching to moisturized surfaces during colonization. Alginate is an important component as it is essential for retention of water and nutrients in biofilms. Read More

    Use of a neural network to predict normalized signal strengths from a DNA-sequencing microarray.
    Bioinformation 2017 30;13(9):313-317. Epub 2017 Sep 30.
    Department of Computer Science.
    A microarray DNA sequencing experiment for a molecule of N bases produces a 4xN data matrix, where for each of the N positions each quartet comprises the signal strength of binding of an experimental DNA to a reference oligonucleotide affixed to the microarray, for the four possible bases (A, C, G, or T). The strongest signal in each quartet should result from a perfect complementary match between experimental and reference DNA sequence, and therefore indicate the correct base call at that position. The linear series of calls should constitute the DNA sequence. Read More

    Analysis of predicted B and T-cell epitopes in Der p 23, allergen from Dermatophagoides pteronyssinus.
    Bioinformation 2017 30;13(9):307-312. Epub 2017 Sep 30.
    Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences-International Campus (IC-TUMS) Tehran, Iran.
    House dust mite (HDM) allergy is the leading cause of IgE-mediated hypersensitivity. Therefore identifying potential epitopes in the Dermatophagoide pteronyssinus 23 (Der p 23), a major house dust mite allergen will aid in the development of therapeutic vaccines and diagnostic kits for HDM allergy. Experimental methods of epitope discovery have been widely exploited for the mapping of potential allergens. Read More

    Prediction aided in vitro analysis of octa-decanoic acid from Cyanobacterium Lyngbya sp. as a proapoptotic factor in eliciting anti-inflammatory properties.
    Bioinformation 2017 30;13(9):301-306. Epub 2017 Sep 30.
    Department of Microbiology, Bharathidasan University, Tiruchirappalli - 620024, Tamilnadu, India.
    Marine Lyngbya has been proven as a potent anticancer agent by disrupting microfilament network. Lyngbya and its associated cyanobacterial compounds have been stressed for futuristic advancements in cancer research and have foreseen explicit advancements in the recent era. Moreover, compounds like lyngbyabellins, lyngbyastatins and other derived toxins are significantly studied. Read More

    Molecular docking analysis of aplysin analogs targeting survivin protein.
    Bioinformation 2017 30;13(9):293-300. Epub 2017 Sep 30.
    Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow, Uttar Pradesh, India-226026.
    Survivin (IAP proteins) remains an important target for anticancer drug development as it is reported to be over-expressed in tumor cells to enhance resistance to apoptotic stimuli. The study focuses on virtual screening of marine compounds inhibiting survivin, a multifunctional protein, using a computational approach. Structures of compounds were prepared using ChemDraw Ultra 10. Read More

    Molecular docking based screening of triterpenoids as potential G-quadruplex stabilizing ligands with anti-cancer activity.
    Bioinformation 2017 30;13(9):284-292. Epub 2017 Sep 30.
    Department of Pharmacology, Faculty of Science, Mahidol University, 272 Rama 6 Road, Bangkok 10400, Thailand.
    Triterpenoids isolated from Ganoderma lucidum (GLTs) exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic activities. Current research studies revealed the role by GLTs in inducing apoptosis and suppression of telomerase activity of cancer cells with much lower toxicity to healthy cells. Compounds selectively binding and stabilizing G-quadruplex structures could inhibit the telomerase or downregulate the oncogenes and may act as anti-cancer agents. Read More

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