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    1021 results match your criteria Biogerontology[Journal]

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    Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.
    Biogerontology 2018 Jun 15. Epub 2018 Jun 15.
    Progeria Research Team, Healthy Ageing Theme, Institute for Environment, Health and Societies, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, UB8 3PH, UK.
    Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal premature ageing disease in children. HGPS is one of several progeroid syndromes caused by mutations in the LMNA gene encoding the nuclear structural proteins lamins A and C. In classic HGPS the mutation G608G leads to the formation of a toxic lamin A protein called progerin. Read More

    Applying parametric models to survival data: tradeoffs between statistical significance, biological plausibility, and common sense.
    Biogerontology 2018 Jun 4. Epub 2018 Jun 4.
    N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg, 197758, Russia.
    Parametric models for survival data help to differentiate aging from other lifespan determinants. However, such inferences suffer from small sizes of experimental animal samples and variable animals handling by different labs. We analyzed control data from a single laboratory where interventions in murine lifespan were studied over decades. Read More

    Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells.
    Biogerontology 2018 May 26. Epub 2018 May 26.
    Laboratory of bioengineering and regenerative medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave, Astana, Kazakhstan, Z05H0P9.
    Mesenchymal stem cells (MSCs) represent a promising cell source for cellular therapy and tissue engineering and are currently being tested in a number of clinical trials for various diseases. However, like other somatic cells, MSCs age, and this senescence is accompanied by a progressive decline in stem cell function. Several lines of evidence suggest a role for the Rho family GTPase Cdc42 activity in cellular senescence processes. Read More

    Mitigating peroxynitrite mediated mitochondrial dysfunction in aged rat brain by mitochondria-targeted antioxidant MitoQ.
    Biogerontology 2018 May 17. Epub 2018 May 17.
    Department of Zoology, University of Kalyani, Kalyani, West Bengal, 741235, India.
    Although reactive oxygen species mediated oxidative stress is a well-documented mechanism of aging, recent evidences indicate involvement of nitrosative stress in the same. As mitochondrial dysfunction is considered as one of the primary features of aging, the present study was designed to understand the involvement of nitrosative stress by studying the impact of a mitochondria-targeted antioxidant MitoQ, a peroxynitrite (ONOO) scavenger, on mitochondrial functions. Four groups of rats were included in this study: Group I: Young-6 months (-MitoQ), Group II: Aged-22 months (- MitoQ), Group III: Young-6 months (+ MitoQ), Group IV: Aged-22 months (+ MitoQ). Read More

    Mechanics of population aging and survival.
    Biogerontology 2018 May 10. Epub 2018 May 10.
    Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, 23284-2030, USA.
    In this paper we extend the previous work of Witten and her team on defining a classical physics-driven model of survival in aging populations (Eakin, Bull Math Biol 56(6):1121-1141, 1994; Eakin and Witten, Mech Aging Dev 78(2):85-101, 1995; Witten and Eakin, Exp Gerontol 32(2):259-285, 1997) by revisiting the concept of a force of aging and introducing the concepts of a momentum of aging, a kinetic energy and a potential energy of an aging population. We further extend the analysis beyond the deterministic Newtonian mechanics of a macroscopic population as a whole by considering the probabilistic nature of survival of individual population cohort members, thus producing new statistical physics-based concepts of entropy and of a gerontological "temperature". These new concepts are then illustrated with application to the classic parametric Gompertz survival model, which is a commonly used empirical descriptor for survival dynamics of mammalian species, human populations in particular. Read More

    The impact of aging on CD4 T cell responses to influenza infection.
    Biogerontology 2018 Apr 3. Epub 2018 Apr 3.
    UConn Center on Aging and Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, 06030, USA.
    CD4 T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4 T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearance and prolonged inflammation leading to increased pathology. Current research employing animal models and human subjects has provided new insights into the description and mechanisms of age-related CD4 T cell changes. Read More

    Long-term exposure to TNF-α leads human skin fibroblasts to a p38 MAPK- and ROS-mediated premature senescence.
    Biogerontology 2018 Mar 26. Epub 2018 Mar 26.
    Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", 153 10, Athens, Greece.
    Tumor necrosis factor α (TNF-α) is an inflammatory mediator overexpressed in the skin as a response to ultraviolet radiation, as well as in chronic non-healing wounds. On the other hand, senescent fibroblasts have been shown to accumulate in the skin under these stressful conditions. Accordingly, here we assessed the putative implication of TNF-α in the induction of premature senescence of human adult dermal fibroblasts. Read More

    Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model system.
    Biogerontology 2018 Mar 19. Epub 2018 Mar 19.
    Department of Genetics, Evolution and Environment and Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK.
    High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complexity and heterogeneity of the human microbiome we need robust experimental models that allow the systematic manipulation of variables to test the multitude of hypotheses arisen from large-scale 'meta-omic' projects. Read More

    A review of telomere length in sarcopenia and frailty.
    Biogerontology 2018 Mar 16. Epub 2018 Mar 16.
    Department of Geriatrics, Neurosciences and Orthopedics, A. Gemelli Foundation, Catholic University of the Sacred Heart, School of Medicine, L.go F. Vito 1, 00168, Rome, Italy.
    Sarcopenia and frailty are associated with several important health-related adverse events, including disability, loss of independence, institutionalization and mortality. Sarcopenia can be considered a biological substrate of frailty, and the prevalence of both these conditions progressively increases with age. Telomeres are nucleoprotein structures located at the end of linear chromosomes and implicated in cellular ageing, shorten with age, and are associated with various age-related diseases. Read More

    Involvement of the autophagic pathway in the progression of AMD-like retinopathy in senescence-accelerated OXYS rats.
    Biogerontology 2018 Feb 28. Epub 2018 Feb 28.
    Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia.
    Age-related macular degeneration (AMD) is a complex neurodegenerative disease resulting in a loss of central vision in the elderly. It is currently assumed that impairment of autophagy may be one of the key mechanisms leading to AMD. Here we estimated the influence of age-related autophagy alterations in the retina on the development of AMD-like retinopathy in senescence-accelerated OXYS rats. Read More

    Gene expression hallmarks of cellular ageing.
    Biogerontology 2018 Feb 28. Epub 2018 Feb 28.
    Epigenetics Programme, Babraham Institute, Cambridge, UK.
    Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven by highly conserved cell intrinsic processes, and a set of unifying hallmarks of ageing has been defined. Here, we survey reports of age-linked changes in basal gene expression across eukaryotes from yeast to human and identify six gene expression hallmarks of cellular ageing: downregulation of genes encoding mitochondrial proteins; downregulation of the protein synthesis machinery; dysregulation of immune system genes; reduced growth factor signalling; constitutive responses to stress and DNA damage; dysregulation of gene expression and mRNA processing. Read More

    Mitochondria, its DNA and telomeres in ageing and human population.
    Biogerontology 2018 Feb 28. Epub 2018 Feb 28.
    Latvian Biomedical Research and Study Centre, Ratsupites Street 1, Riga, 1067, Latvia.
    In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to slow down or even prevent these diseases and provide opportunities for healthy ageing; additionally, we all want to live longer. Read More

    Polyphenols protect against age-associated apoptosis in female rat cochleae.
    Biogerontology 2018 Apr 23;19(2):159-169. Epub 2018 Jan 23.
    European University of Madrid, Calle del Tajo S/N, Villaviciosa de Odón, 28670, Madrid, Spain.
    Dietary antioxidants, polyphenols, have been found to be beneficial in protecting against the generation of oxidative stress in various diseases associated with aging. Age-related hearing loss (AHL) is the number one neurodegenerative disorder on our aged population. Sprague-Dawley rats divided into five groups according to their age (3, 6, 12, 18 and 24 months old) and treated with 100 mg/day/kg body weight of polyphenols were used. Read More

    Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers.
    Biogerontology 2018 Apr 16;19(2):145-157. Epub 2018 Jan 16.
    School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332-0230, USA.
    Pharmaceutical interventions can slow aging in animals, and have advantages because their dose can be tightly regulated and the timing of the intervention can be closely controlled. They also may complement environmental interventions like caloric restriction by acting additively. A fertile source for therapies slowing aging is FDA approved drugs whose safety has been investigated. Read More

    Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging.
    Biogerontology 2018 Apr 16;19(2):121-132. Epub 2018 Jan 16.
    Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia.
    Albeit aging is an inevitable process, the rate of aging is susceptible to modifications. Dietary restriction (DR) is a vigorous nongenetic and nonpharmacological intervention that is known to delay aging and increase healthspan in diverse species. This study aimed to compare the impact of different restricting feeding regimes such as limited daily feeding (LDF, 60% AL) and intermittent feeding (IF) on brain energy homeostasis during aging. Read More

    Repurposing existing drugs for new AMPK activators as a strategy to extend lifespan: a computer-aided drug discovery study.
    Biogerontology 2018 Apr 15;19(2):133-143. Epub 2018 Jan 15.
    Department of Biology, Faculty of Science, Golestan University, Gorgan, Iran.
    Dietary restriction is one of the several ways which could putatively extend organisms' lifespan, ranging from Saccharomyces cerevisiae to rodents, by activating the AMP-activated protein kinase (AMPK), an ATP/AMP sensor. Extensive researches have shown that aging reduces sensibility of AMPK and eventually causes energy imbalance in cells. Research in mammals' AMPK depicts that this signaling molecule could control autophagy, improve cellular stress resistance and suppress inflammatory responses. Read More

    Organ reserve, excess metabolic capacity, and aging.
    Biogerontology 2018 Apr 15;19(2):171-184. Epub 2018 Jan 15.
    School of Medicine, California University of Science and Medicine (CUSM), 217 E Club Center Dr. Suite A, San Bernardino, CA, 92408, USA.
    "Organ reserve" refers to the ability of an organ to successfully return to its original physiological state following repeated episodes of stress. Clinical evidence shows that organ reserve correlates with the ability of older adults to cope with an added workload or stress, suggesting a role in the process of aging. Although organ reserve is well documented clinically, it is not clearly defined at the molecular level. Read More

    A network-based meta-analysis for characterizing the genetic landscape of human aging.
    Biogerontology 2018 Feb 21;19(1):81-94. Epub 2017 Dec 21.
    Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Viale Druso 1, 39100, Bolzano, Italy.
    Great amounts of omics data are generated in aging research, but their diverse and partly complementary nature requires integrative analysis approaches for investigating aging processes and connections to age-related diseases. To establish a broader picture of the genetic and epigenetic landscape of human aging we performed a large-scale meta-analysis of 6600 human genes by combining 35 datasets that cover aging hallmarks, longevity, changes in DNA methylation and gene expression, and different age-related diseases. To identify biological relationships between aging-associated genes we incorporated them into a protein interaction network and characterized their network neighborhoods. Read More

    Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans.
    Biogerontology 2018 Apr 18;19(2):109-120. Epub 2017 Dec 18.
    Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR, Palacký University, Šlechtitelů 27, 78371, Olomouc, Czech Republic.
    Cytokinins are phytohormones that are involved in many processes in plants, including growth, differentiation and leaf senescence. However, they also have various activities in animals. For example, kinetin and trans-zeatin can reduce levels of several aging markers in human fibroblasts. Read More

    Cell wall biosynthesis impairment affects the budding lifespan of the Saccharomyces cerevisiae yeast.
    Biogerontology 2018 Feb 30;19(1):67-79. Epub 2017 Nov 30.
    Department of Plant Physiology, Institute of Biotechnology, University of Rzeszow, Rzeszow, Poland.
    The Saccharomyces cerevisiae yeast is one of the most widely used model in studies of cellular and organismal biology, including as aging and proliferation. Although several constraints of aging and budding lifespan have been identified, these processes have not yet been fully understood. Previous studies of aging in yeast have focused mostly on the molecular basics of the underlying mechanisms, while physical aspects, particularly those related to the cell wall, were rather neglected. Read More

    Echinacoside, a phenylethanoid glycoside from Cistanche deserticola, extends lifespan of Caenorhabditis elegans and protects from Aβ-induced toxicity.
    Biogerontology 2018 Feb 28;19(1):47-65. Epub 2017 Nov 28.
    Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
    Cistanche deserticola has been found to exert protection against aging and age-related diseases, but mechanisms underlying its longevity effects remain largely unclear. Here, the multicellular model organism Caenorhabditis elegans was employed to identify lifespan extending and protective effects against β-amyloid (Aβ) induced toxicity by echinacoside (ECH), a phenylethanoid glycoside isolated from C. deserticola. Read More

    Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium.
    Biogerontology 2017 Nov 28. Epub 2017 Nov 28.
    Second Department of Internal Medicine, University of Tübingen, Tübingen, Germany.
    The pioneering Swedish OCTO/NONA-Immune longitudinal studies led by Anders Wikby in Jönköping in the 1990s established a cluster of simple baseline immune parameters associated with excess mortality in 85 year-old non-institutionalized individuals over 2, 4 and 6-year follow-up. We dubbed this cluster the "Immune Risk Profile" (IRP) consisting of poor proliferative responses of peripheral blood mononuclear cells to T cell mitogens, accumulations of CD8+ CD28- T-cells resulting in an inverted CD4:8 ratio, decreased amounts of B-cells, and seropositivity for Cytomegalovirus (CMV). The concept of the IRP has since been applied by others to many different populations in different circumstances and at different ages, but in general without specifically establishing whether the same risk factors were relevant in the tested subjects. Read More

    Mutual interactions between telomere heterogeneity and cell culture growth dynamics shape stochasticity of cell aging.
    Biogerontology 2018 Feb 24;19(1):23-31. Epub 2017 Nov 24.
    Department of Molecular Biology, Ruder Boskovic Institute, Bijenicka Cesta 54, 10000, Zagreb, Croatia.
    Mathematical modeling and computational simulations are often used to explain the stochastic nature of cell aging. The models published thus far are based on the molecular mechanisms of telomere biology and how they dictate the dynamics of cell culture proliferation. However, the influence of cell growth conditions on telomere dynamics has been widely overlooked. Read More

    Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster.
    Biogerontology 2018 Feb 27;19(1):33-45. Epub 2017 Nov 27.
    CSIR - Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500007, India.
    The process of aging is a hallmark of the natural life span of all organisms and individuals within a population show variability in the measures of age related performance. Longevity and the rate of aging are influenced by several factors such as genetics, nutrition, stress, and environment. Many studies have focused on the genes that impact aging and there is increasing evidence that epigenetic factors regulate these genes to control life span. Read More

    Murine myoblast migration: influence of replicative ageing and nutrition.
    Biogerontology 2017 Dec 7;18(6):947-964. Epub 2017 Nov 7.
    Stem Cells, Ageing & Molecular Physiology Unit, Research Institute for Sport and Exercise Sciences (RISES), School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
    Cell migration is central to skeletal muscle repair following damage. Leucine and β-Hydroxy β-methylbutyric acid (HMB) are supplements consumed for recovery from muscle damaging exercise in humans, however, their impact on muscle cell migration with age is not yet understood. We hypothesised that replicatively aged ("aged"; P46-P48) myoblasts would be less efficient at basal and supplemented repair versus parental controls ("control"; P12-P16). Read More

    Accumulation of glycated proteins suggesting premature ageing in lamin B receptor deficient mice.
    Biogerontology 2018 Feb 28;19(1):95-100. Epub 2017 Oct 28.
    Clinic for Cardiac und Thoracic Surgery, Martin Luther University of Halle-Wittenberg, 06097, Halle, Germany.
    Accumulation of advanced glycation end products (AGEs) is accompanied by increased free radical activity which contributes to ageing and the development or worsening of degenerative diseases. Apart from other physiological factors, AGEs are also an important biomarker for premature ageing. Here we report protein modifications (glycation) in a mouse model of lamin B receptor deficient ic /ic mice displaying skin defects similar to those of classical progeria. Read More

    Exercise and bone health across the lifespan.
    Biogerontology 2017 Dec 20;18(6):931-946. Epub 2017 Oct 20.
    Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
    With ageing, bone tissue undergoes significant compositional, architectural and metabolic alterations potentially leading to osteoporosis. Osteoporosis is the most prevalent bone disorder, which is characterised by progressive bone weakening and an increased risk of fragility fractures. Although this metabolic disease is conventionally associated with ageing and menopause, the predisposing factors are thought to be established during childhood and adolescence. Read More

    Sexual activity affects the redox profile along the aging process in male rats.
    Biogerontology 2018 Feb 30;19(1):13-21. Epub 2017 Sep 30.
    Laboratório de Estresse Oxidativo, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500 prédio 43431, Porto Alegre, RS, 91501-970, Brazil.
    The disposable soma theory postulates that aging might be the result of tradeoffs between early life reproduction and longevity, thereby involving the costs of reproduction in the expected lifespan. It is known that redox biochemistry plays a major role in these processes. To assess long term effects of reproduction, we analyzed redox rates and the testosterone levels at four different ages, and we performed a principal component analysis between redox measures of five different organs followed by a cluster analysis to determine correlations. Read More

    Diet has independent effects on the pace and shape of aging in Drosophila melanogaster.
    Biogerontology 2018 Feb 15;19(1):1-12. Epub 2017 Sep 15.
    Max-Planck Odense Center on the Biodemography of Aging, Department of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9B, 5000, Odense C, Denmark.
    Studies examining how diet affects mortality risk over age typically characterise mortality using parameters such as aging rates, which condense how much and how quickly the risk of dying changes over time into a single measure. Demographers have suggested that decoupling the tempo and the magnitude of changing mortality risk may facilitate comparative analyses of mortality trajectories, but it is unclear what biologically meaningful information this approach offers. Here, we determine how the amount and ratio of protein and carbohydrate ingested by female Drosophila melanogaster affects how much mortality risk increases over a time-standardised life-course (the shape of aging) and the tempo at which animals live and die (the pace of aging). Read More

    How regularities of mortality statistics explain why we age despite having potentially ageless somatic stem cells.
    Biogerontology 2018 Feb 12;19(1):101-108. Epub 2017 Sep 12.
    Federal Research Center «Computer Science and Control» of the Russian Academy of Sciences, 44-2 Vavilov St., Moscow, Russia, 119333.
    Researchers working in the area of ageing have found numerous manifestations of this process at the molecular biological level, including DNA and protein damage, accumulation of metabolic by-products, lipids peroxidation, macromolecular cross-linking, non-enzymatic glycosylation, anti-oxidant/pro-oxidant misbalance, rising of pro-inflammatory cytokines, etc. This results in an increase in the proportion of cells in growth arrest, reduction of the rate of information processing, metabolic rate decrease, and decrease in rates of other processes characterizing dynamic aspects of the organism's interaction with its environment. Such staggering multilevel diversity in manifestation of senescence precludes (without methodology of systems biology) development of a correct understanding of its primary causes and does not allow for developing approaches capable of postponing ageing or reducing organisms' ageing rate to attain health preservation. Read More

    Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro.
    Biogerontology 2017 Oct 7;18(5):841-854. Epub 2017 Sep 7.
    Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
    Mild stress-induced activation of stress response (SR) pathways, such as autophagy, heat shock response, oxidative SR, DNA damage response, and inflammatory response, can be potentially health beneficial. Using the model system of cellular ageing and replicative senescence in vitro, we have studied the ageing modulatory effects of the two conditions, rapamycin and serum starvation. Chronic exposure to 0. Read More

    Senescence is not inevitable.
    Biogerontology 2017 Dec 28;18(6):965-971. Epub 2017 Aug 28.
    Max Planck Odense Center on the Biodemography of Aging, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
    Senescence, the physiological deterioration resulting in an increase in mortality and decline in fertility with age, is widespread in the animal kingdom and has often been regarded as an inescapable feature of all organisms. This essay briefly describes the history of the evolutionary theoretical ideas on senescence. The canonical evolutionary theories suggest that increasing mortality and decreasing fertility should be ubiquitous. Read More

    Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state.
    Biogerontology 2017 Oct 19;18(5):821-839. Epub 2017 Aug 19.
    Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
    To close the gap in our knowledge of sex influence on age-related changes in inflammation-oxidation state in spinal cord (SC) relevant to inflammation/oxidative-stress associated neuropathologies, 2-3 month-old (young) and 18-20 month-old (old) rats, exhibiting increased level of IL-6, a commonly used marker of inflamm-aging, were examined for inflammatory/redox status, and the underlying regulatory networks' molecules expression. With age, rat SC microglia became sensitized ("primed"), while SC tissue shifted towards mild inflammatory state, with increased levels of proinflammatory IL-1β (key marker of microglial systemic inflammation-induced neurotoxicity), which was more prominent in males. This, most likely, reflected age- and sex-related impairment in the expression of CX3CR1, the receptor for fractalkine (CX3CL1), the soluble factor which regulates microglial activation and diminishes production of IL-1β (central for fractalkine neuroprotection). Read More

    A genome-wide association study of cognitive function in Chinese adult twins.
    Biogerontology 2017 Oct 14;18(5):811-819. Epub 2017 Aug 14.
    Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
    Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world's largest and rapidly aging Chinese population. The paper aimed to identify the specific genetic variants associated with cognitive function in middle and old-aged Chinese dizygotic twins (DZ). Read More

    Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing.
    Biogerontology 2017 Dec 9;18(6):913-929. Epub 2017 Aug 9.
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UK.
    The field of the biology of ageing has received increasing attention from a biomedical point of view over the past decades. The main reason has been the realisation that increases in human population life expectancy are accompanied by late onset diseases. Indeed, ageing is the most important risk factor for a number of neoplastic, neurodegenerative and metabolic pathologies. Read More

    Reproduction, ageing, and longevity in two species of laboratory rodents with different life histories.
    Biogerontology 2017 Oct 24;18(5):803-809. Epub 2017 Jul 24.
    Institute of Systematics and Ecology of Animals, Siberian Branch of the Russian Academy of Sciences, Frunze Street 11, Novosibirsk, Russia, 630091.
    Social subterranean rodents of the Bathyergidae family are known to have extended longevity and some signs of negligible senescence, although the manifestation of these traits depends on the reproductive status of individuals. Such enormous life history peculiarities are usually explained by the specificity of a subterranean way of life. If so, all subterranean rodents, regardless of their taxonomic position, are expected to have higher maximum lifespans and shorter senescence periods than the related above-ground species. Read More

    Plant extracts and natural compounds used against UVB-induced photoaging.
    Biogerontology 2017 Aug 12;18(4):499-516. Epub 2017 Jul 12.
    Institute for Biomedical Aging Research, University of Innsbruck, Rennweg 10, 6020, Innsbruck, Austria.
    Skin is continuously exposed to a variety of environmental stresses, including ultraviolet (UV) radiation. UVB is an inherent component of sunlight that crosses the epidermis and reaches the upper dermis, leading to increased oxidative stress, activation of inflammatory response and accumulation of DNA damage among other effects. The increase in UVB radiation on earth due to the destruction of stratospheric ozone poses a major environmental threat to the skin, increasing the risk of damage with long-term consequences, such as photoaging and photocarcinogenesis. Read More

    A mild cold stress that increases resistance to heat lowers FOXO translocation in Drosophila melanogaster.
    Biogerontology 2017 Oct 4;18(5):791-801. Epub 2017 Jul 4.
    Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI Toulouse), Université de Toulouse, CNRS, UPS, Toulouse, France.
    Previous studies have shown that subjecting Drosophila melanogaster flies to a mild stress at young or middle age can increase lifespan and resistance to severe stresses throughout life and that the NF-κB-like transcription factor DIF, the 70 kDa heat-shock proteins, and the Drosophila Forkhead box class O (dFOXO) transcription factor could explain some of these effects. The present study showed that two dFOXO mutants do not survive longer heat if previously subjected to a mild cold stress, contrarily to wild-type flies. This cold pretreatment had nearly no effect on dFOXO nuclear translocation in wild-type males. Read More

    Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner.
    Biogerontology 2017 Aug 22;18(4):665-677. Epub 2017 Jun 22.
    Stem Cell Bioengineering Unit, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.
    Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Read More

    Aging effect on the instrumented Timed-Up-and-Go test variables in nursing home women aged 80-93 years.
    Biogerontology 2017 Aug 20;18(4):651-663. Epub 2017 Jun 20.
    The Jerzy Kukuczka Academy of Physical Education in Katowice, 72A Mikołowska Str., 40-065, Katowice, Poland.
    Although the total "Timed-Up-and Go" test (TUG) performance time can characterize an age-related decline of general mobility, this result alone doesn't give any detailed information about the test subtasks. The primary objective of the study was to identify in nursing home women a variable extracted from instrumented TUG (iTUG) that is the best predictor of age. The secondary objective was to assess whether this variable is associated with the results of the isometric knee extension peak torque (IKEPT); lower limb strength measured by the 30-s chair stand test (30sCST), and walking capacity measured by the 6-min walk test (6MWT). Read More

    Towards ageing well: Use it or lose it: Exercise, epigenetics and cognition.
    Biogerontology 2017 Aug 17;18(4):679-691. Epub 2017 Jun 17.
    School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast, BT7 INN, Northern Ireland, UK.
    More and more people are living into the 90s or becoming centenarians. But, the gift of increased 'age span' seldom equates with an improved 'health-span'. Governments across the world are expressing concern about the epidemic of chronic disease, and have responded by initiating policies that make prevention, reduction and treatment of chronic disease, a public health priority. Read More

    Frailty phenotype and the role of levodopa challenge test in geriatric inpatients with mild parkinsonian signs.
    Biogerontology 2017 Aug 13;18(4):641-650. Epub 2017 Jun 13.
    John Paul II Geriatric Hospital, Research and Development Centre, Katowice, Poland.
    Deficiency in dopaminergic system function may be one of the hypothetical reasons of the frailty syndrome but its role still remains unclear. The aim of our study was to assess the frailty phenotype prevalence in geriatric inpatients with mild parkinsonian signs (MPS) and to investigate levodopa test in the frail patients with MPS. We examined 118 participants: 90 with MPS and 28 in control group (without MPS). Read More

    Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented.
    Biogerontology 2017 Oct 8;18(5):769-790. Epub 2017 Jun 8.
    School of Anatomy, Physiology and Human Biology, The University of Western Australia (UWA), Perth, WA, 6009, Australia.
    The ability of resistance exercise, initiated from mid-life, to prevent age-related changes in old sciatic nerves, was investigated in male and female C57BL/6J mice. Aging is associated with cellular changes in old sciatic nerves and also loss of skeletal muscle mass and function (sarcopenia). Mature adult mice aged 15 months (M) were subjected to increasing voluntary resistance wheel exercise (RWE) over a period of 8 M until 23 M of age. Read More

    Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.
    Biogerontology 2017 Aug 2;18(4):615-630. Epub 2017 Jun 2.
    Neurobiology and Molecular Chronobiology Laboratory, Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.
    Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels and daily pulses. To identify biomarkers of aging and PD chronomics of proteomic day-night profiles in suprachiasmatic nucleus (SCN), pineal and substantia nigra (SN) in 3 month (m), 12, 24 m and RIPD rat model were studied at two time points i. Read More

    Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans.
    Biogerontology 2017 Aug 1;18(4):485-497. Epub 2017 Jun 1.
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
    In evolutionary terms, life on the planet has taken the form of independently living cells for the majority of time. In comparison, the mammalian radiation is a relatively recent event. The common mammalian ancestor was probably small and short-lived. Read More

    The budding yeast Saccharomyces cerevisiae as a model organism: possible implications for gerontological studies.
    Biogerontology 2017 Aug 1;18(4):631-640. Epub 2017 Jun 1.
    Department of Biochemistry and Cell Biology, University of Rzeszow, Zelwerowicza 4, 35-601, Rzeszow, Poland.
    Experimental gerontology is based on the fundamental assumption that the aging process has a universal character and that the mechanisms of aging are well-conserved among living things. The consequence of this assumption is the use of various organisms, including unicellular yeast Saccharomyces cerevisiae, as models in gerontology, and direct extrapolation of the conclusions drawn from the studies carried on these organisms to human beings. However, numerous arguments suggest that aging is not universal and its mechanisms are not conserved in a wide range of species. Read More

    Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
    Biogerontology 2017 Dec 24;18(6):859-879. Epub 2017 May 24.
    Life & Health Sciences, Aston University, Birmingham, UK.
    Lipids are essential for physiological processes such as maintaining membrane integrity, providing a source of energy and acting as signalling molecules to control processes including cell proliferation, metabolism, inflammation and apoptosis. Disruption of lipid homeostasis can promote pathological changes that contribute towards biological ageing and age-related diseases. Several age-related diseases have been associated with altered lipid metabolism and an elevation in highly damaging lipid peroxidation products; the latter has been ascribed, at least in part, to mitochondrial dysfunction and elevated ROS formation. Read More

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