1,140 results match your criteria Biogerontology[Journal]


Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function.

Biogerontology 2020 May 23. Epub 2020 May 23.

Musculoskeletal Science & Sports Medicine Research Centre, Dept. of Life Sciences, Faculty of Science & Engineering, Manchester Metropolitan University, Manchester, UK.

The loss of muscle mass and function with age, termed sarcopenia, is an inevitable process, which has a significant impact on quality of life. During ageing we observe a progressive loss of total muscle fibres and a reduction in cross-sectional area of the remaining fibres, resulting in a significant reduction in force output. The mechanisms which underpin sarcopenia are complex and poorly understood, ranging from inflammation, dysregulation of protein metabolism and denervation. Read More

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http://dx.doi.org/10.1007/s10522-020-09883-xDOI Listing

Longevity-promoting efficacies of rutin in high fat diet fed Drosophila melanogaster.

Biogerontology 2020 May 20. Epub 2020 May 20.

206, Structural Biology Lab, Centre for Biomedical Research, School of Bio Sciences & Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

Composition of diet significantly impacts lifespan in Drosophila melanogaster. Diet-composition becomes even more crucial while assessing a phytocompound for probable pro-longevity effects in flies. Rutin is a flavonol glycoside present in apple, buckwheat, black tea and green tea. Read More

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http://dx.doi.org/10.1007/s10522-020-09882-yDOI Listing

Functional alterations and transcriptomic changes during zebrafish cardiac aging.

Biogerontology 2020 May 5. Epub 2020 May 5.

School of Basic Medical Sciences, Wuhan University, Wuhan, China.

Aging dramatically increases the risk of cardiovascular diseases in human. Animal models are of great value to study cardiac aging, and zebrafish have become a popular model for aging study recently. However, there is limited knowledge about the progression and regulation of cardiac aging in zebrafish. Read More

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http://dx.doi.org/10.1007/s10522-020-09881-zDOI Listing

Epigenetic changes during ageing and their underlying mechanisms.

Biogerontology 2020 Apr 30. Epub 2020 Apr 30.

Department of Biochemistry and Tissue Biology, University of Campinas, Rua Monteiro Lobato, 255, Campinas, São Paulo, 13083-862, Brazil.

As life expectancy increases worldwide, ageing and age-related diseases arise as a major issue for societies around the globe. Understanding the biological mechanisms underlying the ageing process is thus instrumental for the development of efficient interventions aimed to prevent and treat age-related conditions. Current knowledge in the biogerontology field points to epigenetics as a critical component of the ageing process, not only by serving as a bona-fide marker of biological age but also by controlling and conferring inheritability to cellular and organismal ageing. Read More

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http://dx.doi.org/10.1007/s10522-020-09874-yDOI Listing
April 2020
3.290 Impact Factor

The redox environment and mitochondrial dysfunction in age-related skeletal muscle atrophy.

Biogerontology 2020 Apr 22. Epub 2020 Apr 22.

Discipline of Physiology, School of Medicine, National University of Ireland Galway, Galway, Ireland.

Medical advancements have extended human life expectancy, which is not always accompanied by an improved quality of life or healthspan. A decline in muscle mass and function is a consequence of ageing and can result in a loss of independence in elderly individuals while increasing their risk of falls. Multiple cellular pathways have been implicated in age-related muscle atrophy, including the contribution of reactive oxygen species (ROS) and disrupted redox signalling. Read More

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http://dx.doi.org/10.1007/s10522-020-09879-7DOI Listing

Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing.

Biogerontology 2020 Apr 13. Epub 2020 Apr 13.

Department of Pharmacy, and Zhejiang Provincial Key Laboratory of Ageing and Neurological Disorder Research, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

The vascular endothelium is a protective barrier between the bloodstream and the vasculature that may be disrupted by different factors such as the presence of diseased states. Diseases like diabetes and obesity pose a great risk toward endothelial cell inflammation and oxidative stress, leading to endothelial cell dysfunction and thereby cardiovascular complications such as atherosclerosis. Sirtuins are NAD-dependent histone deacetylases that are implicated in the pathophysiology of cardiovascular diseases, and they have been identified to be important regulators of endothelial cell function. Read More

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http://dx.doi.org/10.1007/s10522-020-09873-zDOI Listing

Age-related chemokine alterations affect IgA secretion and gut immunity in female mice.

Biogerontology 2020 Apr 10. Epub 2020 Apr 10.

Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.

The chemokines CCL25 and CCL28, which promote immune cell migration, are primarily expressed in the small and large intestines and play critical roles in sustaining gut immunity. In particular, these chemokines are closely related to intestinal IgA secretion. However, there is no research regarding the effects of aging on CCL25 and CCL28 expression and function. Read More

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http://dx.doi.org/10.1007/s10522-020-09877-9DOI Listing

Novel biomarkers for the evaluation of aging-induced proteinopathies.

Biogerontology 2020 Apr 9. Epub 2020 Apr 9.

Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Proteinopathies are characterized by aging related accumulation of misfolded protein aggregates. Irreversible covalent modifications of aging proteins may significantly affect the native three dimentional conformation of proteins, alter their function and lead to accumulation of misfolded protein as dysfunctional aggregates. Protein misfolding and accumulation of aberrant proteins are known to be associated with aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease and islet amyloid polypeptides in Type 2 diabetes mellitus. Read More

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http://dx.doi.org/10.1007/s10522-020-09878-8DOI Listing
April 2020
3.290 Impact Factor

Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats.

Biogerontology 2020 Apr 5. Epub 2020 Apr 5.

Neurobiology and Molecular Chronobiology Laboratory, Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.

The temporal expression pattern of the circadian clock genes are known to be altered/attenuated with advance in age. Withania somnifera (WS) essentially consists of numerous active constituents including withanolides is known to have antioxidant, anti-inflammatory and adaptogenic properties. We have earlier demonstrated therapeutic effects of hydro-alcoholic leaf extract of WS on the age-induced alterations in the levels and daily rhythms of various clock genes such as rBmal1, rPer1, rPer2 and rCry1. Read More

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http://dx.doi.org/10.1007/s10522-020-09875-xDOI Listing

The roles of MTOR and miRNAs in endothelial cell senescence.

Biogerontology 2020 Apr 3. Epub 2020 Apr 3.

Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Accumulation of senescent cells in vascular endothelium is known to contribute to vascular aging and increases the risk of developing cardiovascular diseases. The involvement of classical pathways such as p53/p21 and p16/pRB in cellular senescence are well described but there are emerging evidence supporting the increasingly important role of mammalian target of rapamycin (MTOR) as driver of cellular senescence via these pathways or other effector molecules. MicroRNAs (miRNAs) are a highly conserved group of small non-coding RNAs (18-25 nucleotides), instrumental in modulating the expression of target genes associated with various biological and cellular processes including cellular senescence. Read More

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http://dx.doi.org/10.1007/s10522-020-09876-wDOI Listing

Effects of lifelong exercise and aging on the blood metabolic fingerprint of rats.

Biogerontology 2020 Mar 29. Epub 2020 Mar 29.

Laboratory of Evaluation of Human Biological Performance, School of Physical Education and Sports Science, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Regular exercise is an important part of a healthy lifestyle, as it helps maintain a healthy weight and reduces the risk of chronic diseases. We explored the effects of lifelong exercise and aging on rat metabolism through a metabolomics approach. Thirty-six rats were divided into four equal groups: exercise during the 1st half of life (3-12 months), lifelong exercise (3-21 months), no exercise, and exercise during the 2nd half of life (12-21 months). Read More

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http://dx.doi.org/10.1007/s10522-020-09871-1DOI Listing

The sciences of healthy aging await a theory of health.

Authors:
Jonathan Sholl

Biogerontology 2020 Jun 19;21(3):399-409. Epub 2020 Mar 19.

Department of Philosophy and History of Ideas, Aarhus University, Jens Chr. Skous Vej 7, 8000, Aarhus, Denmark.

Debates in fields studying the biological aspects of aging and longevity, such as biogerontology, are often split between 'anti-aging' approaches aimed largely at treating diseases and those focusing more on maintaining, promoting, and even enhancing health. However, it is far from clear what this 'health' is that would be maintained, promoted, or enhanced. Interestingly, what few have yet to fully reflect on is that there is still no theory of health within the health or aging sciences that would provide an integrative explanatory framework akin to other scientific theories. Read More

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http://dx.doi.org/10.1007/s10522-020-09872-0DOI Listing

Characterisation of the positive effects of mild stress on ageing and resistance to stress.

Authors:
Éric Le Bourg

Biogerontology 2020 Mar 18. Epub 2020 Mar 18.

Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI Toulouse), Université de Toulouse, CNRS, UPS, Toulouse, France.

The positive effects of mild stress on ageing, lifespan and resistance to stress have been studied mainly in Drosophila melanogaster flies and in the nematode Caenorhabditis elegans. These studies now allow to know the effects of the strength of the mild stress and of the number of exposures, the duration of the positive effects, if mild stress is effective when applied at any age, and whether combining two or three mild stresses is more efficient than a single one. This article summarises these results. Read More

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http://dx.doi.org/10.1007/s10522-020-09870-2DOI Listing

Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response.

Biogerontology 2020 Mar 18. Epub 2020 Mar 18.

Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, São Paulo, Brazil.

Human HSP27 is a small heat shock protein that modulates the ability of cells to respond to heat shock and oxidative stress, and also functions as a chaperone independent of ATP, participating in the proteasomal degradation of proteins. The expression of HSP27 is associated with survival in mammalian cells. In cancer cells, it confers resistance to chemotherapy; in neurons, HSP27 has a positive effect on neuronal viability in models of Alzheimer's and Parkinson's diseases. Read More

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http://dx.doi.org/10.1007/s10522-020-09869-9DOI Listing

17β-estradiol inhibits HO-induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy.

Biogerontology 2020 Mar 14. Epub 2020 Mar 14.

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.

17β-estradiol (17β-E) has been implicated in inhibiting the senescence of vascular endothelial cells (VEC) and slowing down the process of atherosclerosis. However, the underlying molecular mechanisms are still unknown. In this study, we examined the roles of SIRT3 in 17β-E-induced autophagy and 17β-E-mediated inhibition of hydrogen peroxide (HO)-induced senescence in Human umbilical vein endothelial cells (HUVEC). Read More

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http://dx.doi.org/10.1007/s10522-020-09868-wDOI Listing

Natural anti-aging skincare: role and potential.

Biogerontology 2020 Jun 11;21(3):293-310. Epub 2020 Mar 11.

Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

The deterioration of the skin morphology and physiology is the first and earliest obvious harbinger of the aging process which is progressively manifested with increasing age. Such deterioration affects the vital functions of the skin such as homeodynamic regulation of body temperature, fluid balance, loss of electrolytes and proteins, production of vitamin D, waste removal, immune surveillance, sensory perception, and protection of other organs against deleterious environmental factors. There are, however, harmful chemicals and toxins found in everyday cosmetics that consumers are now aware of. Read More

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http://dx.doi.org/10.1007/s10522-020-09865-zDOI Listing
June 2020
3.290 Impact Factor

Informative frailty indices from binarized biomarkers.

Biogerontology 2020 Jun 10;21(3):345-355. Epub 2020 Mar 10.

Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Canada.

Frailty indices (FIs) based on continuous valued health data, such as obtained from blood and urine tests, have been shown to be predictive of adverse health outcomes. However, creating FIs from such biomarker data requires a binarization treatment that is difficult to standardize across studies. In this work, we explore a "quantile" methodology for the generic treatment of biomarker data that allows us to construct an FI without preexisting medical knowledge (i. Read More

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http://dx.doi.org/10.1007/s10522-020-09863-1DOI Listing

Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice.

Biogerontology 2020 Jun 4;21(3):367-380. Epub 2020 Mar 4.

Department of Life Sciences, National Cheng Kung University, No. 1, University Road, Tainan, Taiwan.

The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarcopenia at 40 weeks of age and were more time-efficient than that at 88 weeks of age in bothSAM resistant 1 (SAMR1) and C57BL/6 mice. Read More

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http://dx.doi.org/10.1007/s10522-020-09867-xDOI Listing

The crosstalk of NAD, ROS and autophagy in cellular health and ageing.

Biogerontology 2020 Jun 3;21(3):381-397. Epub 2020 Mar 3.

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

Cellular adaptation to various types of stress requires a complex network of steps that altogether lead to reconstitution of redox balance, degradation of damaged macromolecules and restoration of cellular metabolism. Advances in our understanding of the interplay between cellular signalling and signal translation paint a complex picture of multi-layered paths of regulation. In this review we explore the link between cellular adaptation to metabolic and oxidative stresses by activation of autophagy, a crucial cellular catabolic pathway. Read More

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http://dx.doi.org/10.1007/s10522-020-09864-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196094PMC

Bioinformatic framework for analysis of transcription factor changes as the molecular link between replicative cellular senescence signaling pathways and carcinogenesis.

Biogerontology 2020 Jun 26;21(3):357-366. Epub 2020 Feb 26.

Institute of Chemical Biology, National Hellenic Research Foundation, 11635, Athens, Greece.

Cellular senescence is a natural condition of irreversible cell cycle arrest and apoptotic resistance that occurs in cells exposed to various stress factors, such as replicative stress or overexpression of oncogenes. Unraveling the complex regulation of senescence in cells is essential to strengthen senescence-related therapeutic approaches in cancer, as cellular senescence plays a dual role in tumorigenesis, having both anti- and pro-tumorigenic effects. In our study we created a model of replicative cellular senescence, based on transcriptomic data, including an extra intermediate time-point prior to cells entering senescence, to elucidate the interplay of networks governing cellular senescence with networks involved in tumorigenesis. Read More

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http://dx.doi.org/10.1007/s10522-020-09866-yDOI Listing

MicroRNAs, DNA damage response and ageing.

Biogerontology 2020 Jun 18;21(3):275-291. Epub 2020 Feb 18.

Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Ageing is a multifactorial and integrated gradual deterioration affecting the most of biological process of cells. MiRNAs are differentially expressed in the cellular senescence and play important role in regulating of genes expression involved in features of ageing. The perception of miRNAs functions in ageing regulation can be useful in clarifying the mechanisms underlying ageing and designing of therapeutic strategies. Read More

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http://dx.doi.org/10.1007/s10522-020-09862-2DOI Listing
June 2020
3.290 Impact Factor

Alzheimer's disease: targeting the glutamatergic system.

Authors:
Myra E Conway

Biogerontology 2020 Jun 11;21(3):257-274. Epub 2020 Feb 11.

Faculty of Health and Applied Sciences, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, UK.

Alzheimer's disease (AD) is a debilitating neurodegenerative disease that causes a progressive decline in memory, language and problem solving. For decades mechanism-based therapies have primarily focused on amyloid β (Aβ) processing and pathways that govern neurofibrillary tangle generation. With the potential exception to Aducanumab, a monotherapy to target Aβ, clinical trials in these areas have been challenging and have failed to demonstrate efficacy. Read More

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http://dx.doi.org/10.1007/s10522-020-09860-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196085PMC

Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG.

Biogerontology 2020 Jun 10;21(3):325-343. Epub 2020 Feb 10.

Pharmacology and Toxicology Laboratory, Food & Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, 176061, India.

The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impact of secretory metabolites of proliferating (P) and senescent (S) preadipocyte cells on the induction of phenotypic and functional characteristics associated with aging in macrophages isolated from young (YM) and old (OM) C57BL/6J mice. The role of EGCG as alleviator of preadipocyte media-induced senescence and inflamm-aging was evaluated in OM. Read More

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http://dx.doi.org/10.1007/s10522-020-09861-3DOI Listing
June 2020
3.290 Impact Factor

D-Galactose-induced oxidative stress and mitochondrial dysfunction in the cochlear basilar membrane: an in vitro aging model.

Biogerontology 2020 Jun 5;21(3):311-323. Epub 2020 Feb 5.

Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China.

The cochlear basilar membrane (CBM) contains inner hair cells and outer hair cells that convert sound waves into electrical signals and transmit them to the central auditory system. Cochlear aging, the primary reason of age-related hearing loss, can reduce the signal transmission capacity. There is no ideal in vitro aging model of the CBM. Read More

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http://dx.doi.org/10.1007/s10522-020-09859-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196095PMC

Correction to: Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila.

Biogerontology 2020 04;21(2):173-174

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

The article Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila, written by Dmytro V. Gospodaryov. Olha M. Read More

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http://dx.doi.org/10.1007/s10522-020-09858-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056683PMC

Coix seed oil prolongs lifespan and enhances stress resistance in Caenorhabditis elegans.

Biogerontology 2020 04 20;21(2):245-256. Epub 2020 Jan 20.

Putuo District People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.

Coix seed oil (CSO) has many beneficial effects, but there is limited research on its influence on the processes and mechanisms related to senescence. Here, we used Caenorhabditis elegans as an in vivo model to investigate CSO's bioeffects on longevity. CSO (1 mg/mL) significantly extended the mean lifespan of C. Read More

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http://dx.doi.org/10.1007/s10522-020-09857-zDOI Listing

Phosphatidylserine modulates response to oxidative stress through hormesis and increases lifespan via DAF-16 in Caenorhabditis elegans.

Biogerontology 2020 04 8;21(2):231-244. Epub 2020 Jan 8.

Department of Medical Biotechnology, Soonchunhyang University, 22 Soonchunhyang-ro, Asan, Chungnam, 31538, South Korea.

Phosphatidylserine is one of the phospholipids present in cell membranes, especially in brain and nervous system. The phosphatidylserine content is reduced with aging and age-related decrease in phosphatidylserine is known to contribute to cognitive impairment and Alzheimer's disease in the elderly. In the present study, we examined the effect of supplementation with phosphatidylserine on the response to oxidative stress and aging using C. Read More

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http://dx.doi.org/10.1007/s10522-020-09856-0DOI Listing

Oxidative stress resistance in a short-lived Neotropical annual killifish.

Biogerontology 2020 04 20;21(2):217-229. Epub 2019 Dec 20.

Laboratory of Ecology and Conservation of Aquatic Ecosystems, UNISINOS University, São Leopoldo, RS, Brazil.

Oxidative stress plays an important role in the evolution of aging and life history. High investments in life-history traits and environmental conditions can be associated with increased oxidative stress and aging process. However, to date, most studies that investigated variations in oxidative status were performed with long-lived vertebrates. Read More

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http://dx.doi.org/10.1007/s10522-019-09855-wDOI Listing

Aberrant mitochondrial function in ageing and cancer.

Biogerontology 2019 Dec 4. Epub 2019 Dec 4.

The Medical School, Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Alterations in mitochondrial metabolism have been described as one of the major hallmarks of both ageing cells and cancer. Age is the biggest risk factor for the development of a significant number of cancer types and this therefore raises the question of whether there is a link between age-related mitochondrial dysfunction and the advantageous changes in mitochondrial metabolism prevalent in cancer cells. A common underlying feature of both ageing and cancer cells is the presence of somatic mutations of the mitochondrial genome (mtDNA) which we postulate may drive compensatory alterations in mitochondrial metabolism that are advantageous for tumour growth. Read More

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http://dx.doi.org/10.1007/s10522-019-09853-yDOI Listing
December 2019

Goat milk attenuates mimetic aging related memory impairment via suppressing brain oxidative stress, neurodegeneration and modulating neurotrophic factors in D-galactose-induced aging model.

Biogerontology 2020 04 2;21(2):203-216. Epub 2019 Dec 2.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.

One of the most significant hallmarks of aging is cognitive decline. D-galactose administration may impair memory and mimic the effects of natural aging. In this study, the efficiency of goat milk to protect against memory decline was tested. Read More

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http://dx.doi.org/10.1007/s10522-019-09854-xDOI Listing
April 2020
3.290 Impact Factor

Negative genetic correlation between longevity and its hormetic extension by dietary restriction in Drosophila melanogaster.

Biogerontology 2020 04 30;21(2):191-201. Epub 2019 Nov 30.

Facultad de Ciencias Exactas y Naturales, Departamento de Ecología, Genética y Evolución, Universidad de Buenos Aires, C-1428-EHA, Buenos Aires, Argentina.

Longevity is a highly malleable trait which is influenced by many genetic and environmental factors including nutrition. Mild stress of dietary restriction (DR) is often beneficial by extending longevity in many organisms. Here, DR-induced effects on longevity were tested for genetic variation in a set of recombinant inbred lines (RIL) in D. Read More

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http://dx.doi.org/10.1007/s10522-019-09852-zDOI Listing

Naive extrapolations, overhyped claims and empty promises in ageing research and interventions need avoidance.

Biogerontology 2019 Nov 27. Epub 2019 Nov 27.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.

Most proclamations about another wonder breakthrough and another imminent miracle treatment of ageing are usually overhyped claims and empty promises. It is not that the experimental science behind those claims is totally wrong or fake. But it is often a case of being ahistorical and ignoring the cumulated knowledge and understanding of the evolutionary and biological principles of ageing and longevity. Read More

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http://dx.doi.org/10.1007/s10522-019-09851-0DOI Listing
November 2019

Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice.

Biogerontology 2020 04 23;21(2):175-189. Epub 2019 Nov 23.

Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221 005, India.

With advancing age, memory declines through different mechanisms including dysregulation of expression of synaptic plasticity genes in hippocampus. Increasing evidences suggest that these synaptic plasticity genes are regulated through epigenetic modifications. Recently we have reported that the neuronal immediate early genes (IEGs) are regulated by DNA methylation and histone acetylation, and their expression is downregulated in the hippocampus of old male mice, which subsequently results in decline of memory. Read More

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http://dx.doi.org/10.1007/s10522-019-09850-1DOI Listing

Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila.

Biogerontology 2020 04 20;21(2):155-171. Epub 2019 Nov 20.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Mitochondrial alternative NADH dehydrogenase (aNDH) was found to extend lifespan when expressed in the fruit fly. We have found that fruit flies expressing aNDH from Ciona intestinalis (NDX) had 17-71% lifespan prolongation on media with different protein-tocarbohydrate ratios except NDX-expressing males that had 19% shorter lifespan than controls on a high protein diet. NDX-expressing flies were more resistant to organic xenobiotics, 2,4-dichlorophenoxyacetic acid and alloxan, and inorganic toxicant potassium iodate, and partially to sodium molybdate treatments. Read More

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http://dx.doi.org/10.1007/s10522-019-09849-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056681PMC

Metabolic remodelling of mice by hypoxic-hypercapnic environment: imitating the naked mole-rat.

Biogerontology 2020 04 31;21(2):143-153. Epub 2019 Oct 31.

State Institute of Gerontology of National Academy of Medical Sciences of Ukraine, Kiev, Ukraine.

We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not require external sources of gases or complex technical equipment. Here, we showed for the first time that a chronic exposure of mice to HHE could be a unique tool for NMR-like metabolic remodeling, resulting in a long-term and substantial decrease in metabolic rate, body temperature, and food consumption, without significant changes in expression of stress-related genes. Read More

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http://dx.doi.org/10.1007/s10522-019-09848-9DOI Listing

Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast.

Biogerontology 2020 02 28;21(1):109-123. Epub 2019 Oct 28.

Department of Biochemistry and Cell Biology, University of Rzeszow, Zelwerowicza 4, 35-601, Rzeszow, Poland.

Curcumin is a biologically active compound of vegetable origin which has a hormetic effect. Pro-health and anti-aging properties of curcumin have been known for years. The main benefit of curcumin is thought to be its anti-oxidative action. Read More

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http://dx.doi.org/10.1007/s10522-019-09846-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942599PMC
February 2020

Age-related differences in physiology and survival of northern red-backed voles (Myodes rutilus) in captivity.

Biogerontology 2020 04 25;21(2):133-142. Epub 2019 Oct 25.

Department of Vertebrate Zoology, St. Petersburg State University, Universitetskaya nab. 7/9, St. Petersburg, Russia, 199034.

Age-related deterioration of physiological functions is one of the most evident manifestations of ageing. In wild populations of some species, including murid rodents, lifespans are substantially modified by environmental signals that affect an individual's response to such challenges as unfavourable climatic conditions, parasitic load etc. But the real impact of ageing on natural mortality of most species remains obscure. Read More

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http://dx.doi.org/10.1007/s10522-019-09847-wDOI Listing

Age and sex determine CD4+ T cell stimulatory and polarizing capacity of rat splenic dendritic cells.

Biogerontology 2020 02 23;21(1):83-107. Epub 2019 Oct 23.

Department of Pathobiology, Faculty of Pharmacy, University of Belgrade, 450 Vojvode Stepe, Belgrade, 11221, Serbia.

The study investigated influence of sex and age on splenic myeloid dendritic cells (DCs) from Dark Agouti rats. Freshly isolated DCs from young males exhibited less mature phenotype and greater endocytic capacity compared with those from age-matched females. Upon LPS stimulation in vitro they were less potent in stimulating allogeneic CD4+ cells in mixed leukocyte reaction (MLR), due to lower expression of MHC II, and greater NO and IL-10 production. Read More

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http://dx.doi.org/10.1007/s10522-019-09845-yDOI Listing
February 2020

The relationship between leukocyte telomere length and TERT, TRF1 single nucleotide polymorphisms in healthy people of different age groups.

Biogerontology 2020 02 23;21(1):57-67. Epub 2019 Oct 23.

Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania.

Telomeres are nucleoprotein structures that cap the end of each chromosome and function to maintain genome stability. The length of telomeres is known to shorten with each cell division and it is well-established that telomere attrition is related to replicative capacity in vitro. Moreover, telomere loss is also correlated with the process of aging in vivo. Read More

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http://dx.doi.org/10.1007/s10522-019-09843-0DOI Listing
February 2020
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Exercise training in ad libitum and food-restricted old rats: effects on metabolic and physiological parameters.

Biogerontology 2020 02 22;21(1):69-82. Epub 2019 Oct 22.

Interdepartmental Research Centre on Biology and Pathology of Aging, University of Pisa, Via Roma 55, 56126, Pisa, Italy.

Aging is accompanied by a decline in the healthy function of multiple organs, leading to increased incidence and mortality from diseases such as cancer and inflammatory, cardiovascular and neurodegenerative diseases. Dietary restriction is the most effective experimental intervention known to consistently slow the aging process and with positive effects on health span in different organisms, from invertebrates to mammals. Age is also associated with progressive decline in physical activity levels in a wide range of animal species: therefore, regular physical exercise could represent a safe intervention to antagonize aging. Read More

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http://dx.doi.org/10.1007/s10522-019-09844-zDOI Listing
February 2020
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The role of DNA repair genes in radiation-induced adaptive response in Drosophila melanogaster is differential and conditional.

Biogerontology 2020 02 17;21(1):45-56. Epub 2019 Oct 17.

Laboratory of Geroprotective and Radioprotective Technologies, Institute of Biology, Komi Science Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Komi Republic, Russian Federation, 167982.

Studies in human and mammalian cell cultures have shown that induction of DNA repair mechanisms is required for the formation of stimulation effects of low doses of ionizing radiation, named "hormesis". Nevertheless, the role of cellular defense mechanisms in the formation of radiation-induced hormesis at the level of whole organism remains poorly studied. The aim of this work was to investigate the role of genes involved in different mechanisms and stages of DNA repair in radioadaptive response and radiation hormesis by lifespan parameters in Drosophila melanogaster. Read More

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http://dx.doi.org/10.1007/s10522-019-09842-1DOI Listing
February 2020

Why do bats live so long?-Possible molecular mechanisms.

Biogerontology 2020 02 10;21(1):1-11. Epub 2019 Oct 10.

Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Av. Instituto Politécnico Nacional No. 2508, San Pedro Zacatenco, Gustavo A. Madero, 07360, Mexico City, Mexico.

Contrasting with several theories of ageing, bats are mammals with remarkable longevity despite their high metabolic rate, living on average three times more than other mammals of equal size. The question of how bats live a long time has attracted considerable attention, and they have thus been related to immortal fantasy characters like Dracula in the novel by Bram Stoker. Several ecological and physiological features, such as reduction in mortality risks, delayed sexual maturation and hibernation, have been linked to bats' long lifespan. Read More

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http://dx.doi.org/10.1007/s10522-019-09840-3DOI Listing
February 2020
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IL-6 deficiency attenuates p53 protein accumulation in aged male mouse hippocampus.

Biogerontology 2020 02 9;21(1):29-43. Epub 2019 Oct 9.

Department of General and Experimental Pathology, Medical University of Białystok, Mickiewicza 2c, 15-222, Białystok, Poland.

Our earlier studies demonstrated slower age-related memory decline in IL-6-deficient than in control mice. Therefore, in the present study we evaluated the effect of IL-6 deficiency and aging on expression of p53, connected with accumulation of age-related cellular damages, in hippocampus of 4- and 24-month-old IL-6-deficient C57BL/6J (IL-6KO) and wild type control (WT) mice. The accumulation of p53 protein in hippocampus of aged IL-6KO mice was significantly lower than in aged WT ones, while p53 mRNA level was significantly higher in IL-6-deficient mice, what indicates that the effect was independent on p53 transcription. Read More

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http://dx.doi.org/10.1007/s10522-019-09841-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942598PMC
February 2020

Human ageing as a dynamic, emergent and malleable process: from disease-oriented to health-oriented approaches.

Biogerontology 2020 02 8;21(1):125-130. Epub 2019 Oct 8.

Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 6a Chałubińskiego Street, 50-368, Wrocław, Poland.

Over the decades, biogerontology has matured as a scientific discipline. Currently, a number of theoretical frameworks are available to researchers when interpreting empirical data. Despite the great progress that has been made, a comprehensive understanding of biological processes that shape ageing is lacking. Read More

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http://dx.doi.org/10.1007/s10522-019-09839-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942601PMC
February 2020
3.290 Impact Factor

Metformin prevents against oxidative stress-induced senescence in human periodontal ligament cells.

Biogerontology 2020 02 26;21(1):13-27. Epub 2019 Sep 26.

College of Stomatology, Chongqing Medical University, 426# Songshibei Road, Yubei District, Chongqing, 401147, People's Republic of China.

Periodontitis is a chronic infectious disease involving periodontal tissues. Periodontal ligament cells (PDLCs) play an important role in the regeneration of periodontal tissue. However, senescent PDLCs have an impeded regenerative potential. Read More

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http://dx.doi.org/10.1007/s10522-019-09838-xDOI Listing
February 2020
3.290 Impact Factor

Hypergravity increases resistance to heat in dFOXO Drosophila melanogaster mutants and can lower FOXO translocation in wild-type males.

Biogerontology 2019 12 21;20(6):883-891. Epub 2019 Sep 21.

Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI Toulouse), Université de Toulouse, CNRS, UPS, Toulouse, France.

Severe stresses have deleterious effects, but mild stresses can have beneficial effects called hormetic effects. This study observed survival time of wild-type Drosophila melanogaster flies and dFOXO mutants exposed to 37 °C, a severe stress for flies, after they lived or not for 2 weeks in hypergravity (3 or 5 g), a mild stress with hormetic effects in flies. Hypergravity increased survival time of the mutants, this effect being less observed in wild-type flies. Read More

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http://dx.doi.org/10.1007/s10522-019-09836-zDOI Listing
December 2019

D-Galactose-induced accelerated aging model: an overview.

Biogerontology 2019 12 20;20(6):763-782. Epub 2019 Sep 20.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kota Bharu, Kelantan, Malaysia.

To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and affordable anti-aging interventions are deemed necessary. Systemic administration of D-galactose has been established to artificially induce senescence in vitro and in vivo as well as for anti-aging therapeutic interventions studies. The aim of this article is to comprehensively discuss the use of D-galactose to generate a model of accelerated aging and its possible underlying mechanisms involved in different tissues/organs. Read More

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http://dx.doi.org/10.1007/s10522-019-09837-yDOI Listing
December 2019
3.290 Impact Factor

Development, lifespan and reproduction of spider mites exposed to predator-induced stress across generations.

Biogerontology 2019 12 19;20(6):871-882. Epub 2019 Sep 19.

School of Biological Sciences, University of Auckland, Auckland, 1072, New Zealand.

Predator-induced stress shows pronounced effects on prey by inducing behavioural, morphological, and physiological responses. Increasing evidence shows that these antipredator responses may also lead to changes in life-history traits such as aging and lifespan. However, little is known about how predator cues influence the fitness of preys and their transgenerational effects. Read More

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http://dx.doi.org/10.1007/s10522-019-09835-0DOI Listing
December 2019
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In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases.

Biogerontology 2019 12 13;20(6):857-869. Epub 2019 Sep 13.

School of Medical Sciences and Bosch Institute, University of Sydney, Camperdown, NSW, 2006, Australia.

Three-dimensional chromatin architecture and gene-gene interactions impact gene expression. We assembled this information, in silico, for the human renin gene (REN). We searched for chromatin contacts and boundaries and the locations of super-enhancers that are involved in cell specific differentiation. Read More

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http://dx.doi.org/10.1007/s10522-019-09834-1DOI Listing
December 2019
2 Reads

Correction to: Short-term dietary restriction in old mice rejuvenates the aging-induced structural imbalance of gut microbiota.

Biogerontology 2019 Dec;20(6):849-855

Department of Oncology, The Second Affiliated Hospital of Nanchang University, Min-De Road. 1, 330006, Nanchang City, Jiangxi Province, China.

In the original publication of the article, the alphabets in figures were published in upper case and mismatched with the figure legends. The corrected figures and figure legends are given in this Correction. Read More

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http://dx.doi.org/10.1007/s10522-019-09831-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790195PMC
December 2019