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    1009 results match your criteria Biogerontology[Journal]

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    Polyphenols protect against age-associated apoptosis in female rat cochleae.
    Biogerontology 2018 Jan 23. Epub 2018 Jan 23.
    European University of Madrid, Calle del Tajo S/N, Villaviciosa de Odón, 28670, Madrid, Spain.
    Dietary antioxidants, polyphenols, have been found to be beneficial in protecting against the generation of oxidative stress in various diseases associated with aging. Age-related hearing loss (AHL) is the number one neurodegenerative disorder on our aged population. Sprague-Dawley rats divided into five groups according to their age (3, 6, 12, 18 and 24 months old) and treated with 100 mg/day/kg body weight of polyphenols were used. Read More

    Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers.
    Biogerontology 2018 Jan 16. Epub 2018 Jan 16.
    School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332-0230, USA.
    Pharmaceutical interventions can slow aging in animals, and have advantages because their dose can be tightly regulated and the timing of the intervention can be closely controlled. They also may complement environmental interventions like caloric restriction by acting additively. A fertile source for therapies slowing aging is FDA approved drugs whose safety has been investigated. Read More

    Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging.
    Biogerontology 2018 Jan 16. Epub 2018 Jan 16.
    Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia.
    Albeit aging is an inevitable process, the rate of aging is susceptible to modifications. Dietary restriction (DR) is a vigorous nongenetic and nonpharmacological intervention that is known to delay aging and increase healthspan in diverse species. This study aimed to compare the impact of different restricting feeding regimes such as limited daily feeding (LDF, 60% AL) and intermittent feeding (IF) on brain energy homeostasis during aging. Read More

    Repurposing existing drugs for new AMPK activators as a strategy to extend lifespan: a computer-aided drug discovery study.
    Biogerontology 2018 Jan 15. Epub 2018 Jan 15.
    Department of Biology, Faculty of Science, Golestan University, Gorgan, Iran.
    Dietary restriction is one of the several ways which could putatively extend organisms' lifespan, ranging from Saccharomyces cerevisiae to rodents, by activating the AMP-activated protein kinase (AMPK), an ATP/AMP sensor. Extensive researches have shown that aging reduces sensibility of AMPK and eventually causes energy imbalance in cells. Research in mammals' AMPK depicts that this signaling molecule could control autophagy, improve cellular stress resistance and suppress inflammatory responses. Read More

    Organ reserve, excess metabolic capacity, and aging.
    Biogerontology 2018 Jan 15. Epub 2018 Jan 15.
    School of Medicine, California University of Science and Medicine (CUSM), 217 E Club Center Dr. Suite A, San Bernardino, CA, 92408, USA.
    "Organ reserve" refers to the ability of an organ to successfully return to its original physiological state following repeated episodes of stress. Clinical evidence shows that organ reserve correlates with the ability of older adults to cope with an added workload or stress, suggesting a role in the process of aging. Although organ reserve is well documented clinically, it is not clearly defined at the molecular level. Read More

    A network-based meta-analysis for characterizing the genetic landscape of human aging.
    Biogerontology 2018 Feb 21;19(1):81-94. Epub 2017 Dec 21.
    Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Viale Druso 1, 39100, Bolzano, Italy.
    Great amounts of omics data are generated in aging research, but their diverse and partly complementary nature requires integrative analysis approaches for investigating aging processes and connections to age-related diseases. To establish a broader picture of the genetic and epigenetic landscape of human aging we performed a large-scale meta-analysis of 6600 human genes by combining 35 datasets that cover aging hallmarks, longevity, changes in DNA methylation and gene expression, and different age-related diseases. To identify biological relationships between aging-associated genes we incorporated them into a protein interaction network and characterized their network neighborhoods. Read More

    Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans.
    Biogerontology 2017 Dec 18. Epub 2017 Dec 18.
    Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR, Palacký University, Šlechtitelů 27, 78371, Olomouc, Czech Republic.
    Cytokinins are phytohormones that are involved in many processes in plants, including growth, differentiation and leaf senescence. However, they also have various activities in animals. For example, kinetin and trans-zeatin can reduce levels of several aging markers in human fibroblasts. Read More

    Cell wall biosynthesis impairment affects the budding lifespan of the Saccharomyces cerevisiae yeast.
    Biogerontology 2018 Feb 30;19(1):67-79. Epub 2017 Nov 30.
    Department of Plant Physiology, Institute of Biotechnology, University of Rzeszow, Rzeszow, Poland.
    The Saccharomyces cerevisiae yeast is one of the most widely used model in studies of cellular and organismal biology, including as aging and proliferation. Although several constraints of aging and budding lifespan have been identified, these processes have not yet been fully understood. Previous studies of aging in yeast have focused mostly on the molecular basics of the underlying mechanisms, while physical aspects, particularly those related to the cell wall, were rather neglected. Read More

    Echinacoside, a phenylethanoid glycoside from Cistanche deserticola, extends lifespan of Caenorhabditis elegans and protects from Aβ-induced toxicity.
    Biogerontology 2018 Feb 28;19(1):47-65. Epub 2017 Nov 28.
    Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
    Cistanche deserticola has been found to exert protection against aging and age-related diseases, but mechanisms underlying its longevity effects remain largely unclear. Here, the multicellular model organism Caenorhabditis elegans was employed to identify lifespan extending and protective effects against β-amyloid (Aβ) induced toxicity by echinacoside (ECH), a phenylethanoid glycoside isolated from C. deserticola. Read More

    Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium.
    Biogerontology 2017 Nov 28. Epub 2017 Nov 28.
    Second Department of Internal Medicine, University of Tübingen, Tübingen, Germany.
    The pioneering Swedish OCTO/NONA-Immune longitudinal studies led by Anders Wikby in Jönköping in the 1990s established a cluster of simple baseline immune parameters associated with excess mortality in 85 year-old non-institutionalized individuals over 2, 4 and 6-year follow-up. We dubbed this cluster the "Immune Risk Profile" (IRP) consisting of poor proliferative responses of peripheral blood mononuclear cells to T cell mitogens, accumulations of CD8+ CD28- T-cells resulting in an inverted CD4:8 ratio, decreased amounts of B-cells, and seropositivity for Cytomegalovirus (CMV). The concept of the IRP has since been applied by others to many different populations in different circumstances and at different ages, but in general without specifically establishing whether the same risk factors were relevant in the tested subjects. Read More

    Mutual interactions between telomere heterogeneity and cell culture growth dynamics shape stochasticity of cell aging.
    Biogerontology 2018 Feb 24;19(1):23-31. Epub 2017 Nov 24.
    Department of Molecular Biology, Ruder Boskovic Institute, Bijenicka Cesta 54, 10000, Zagreb, Croatia.
    Mathematical modeling and computational simulations are often used to explain the stochastic nature of cell aging. The models published thus far are based on the molecular mechanisms of telomere biology and how they dictate the dynamics of cell culture proliferation. However, the influence of cell growth conditions on telomere dynamics has been widely overlooked. Read More

    Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster.
    Biogerontology 2018 Feb 27;19(1):33-45. Epub 2017 Nov 27.
    CSIR - Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500007, India.
    The process of aging is a hallmark of the natural life span of all organisms and individuals within a population show variability in the measures of age related performance. Longevity and the rate of aging are influenced by several factors such as genetics, nutrition, stress, and environment. Many studies have focused on the genes that impact aging and there is increasing evidence that epigenetic factors regulate these genes to control life span. Read More

    Murine myoblast migration: influence of replicative ageing and nutrition.
    Biogerontology 2017 Dec 7;18(6):947-964. Epub 2017 Nov 7.
    Stem Cells, Ageing & Molecular Physiology Unit, Research Institute for Sport and Exercise Sciences (RISES), School of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
    Cell migration is central to skeletal muscle repair following damage. Leucine and β-Hydroxy β-methylbutyric acid (HMB) are supplements consumed for recovery from muscle damaging exercise in humans, however, their impact on muscle cell migration with age is not yet understood. We hypothesised that replicatively aged ("aged"; P46-P48) myoblasts would be less efficient at basal and supplemented repair versus parental controls ("control"; P12-P16). Read More

    Accumulation of glycated proteins suggesting premature ageing in lamin B receptor deficient mice.
    Biogerontology 2018 Feb 28;19(1):95-100. Epub 2017 Oct 28.
    Clinic for Cardiac und Thoracic Surgery, Martin Luther University of Halle-Wittenberg, 06097, Halle, Germany.
    Accumulation of advanced glycation end products (AGEs) is accompanied by increased free radical activity which contributes to ageing and the development or worsening of degenerative diseases. Apart from other physiological factors, AGEs are also an important biomarker for premature ageing. Here we report protein modifications (glycation) in a mouse model of lamin B receptor deficient ic/icmice displaying skin defects similar to those of classical progeria. Read More

    Exercise and bone health across the lifespan.
    Biogerontology 2017 Dec 20;18(6):931-946. Epub 2017 Oct 20.
    Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
    With ageing, bone tissue undergoes significant compositional, architectural and metabolic alterations potentially leading to osteoporosis. Osteoporosis is the most prevalent bone disorder, which is characterised by progressive bone weakening and an increased risk of fragility fractures. Although this metabolic disease is conventionally associated with ageing and menopause, the predisposing factors are thought to be established during childhood and adolescence. Read More

    Sexual activity affects the redox profile along the aging process in male rats.
    Biogerontology 2018 Feb 30;19(1):13-21. Epub 2017 Sep 30.
    Laboratório de Estresse Oxidativo, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9500 prédio 43431, Porto Alegre, RS, 91501-970, Brazil.
    The disposable soma theory postulates that aging might be the result of tradeoffs between early life reproduction and longevity, thereby involving the costs of reproduction in the expected lifespan. It is known that redox biochemistry plays a major role in these processes. To assess long term effects of reproduction, we analyzed redox rates and the testosterone levels at four different ages, and we performed a principal component analysis between redox measures of five different organs followed by a cluster analysis to determine correlations. Read More

    Diet has independent effects on the pace and shape of aging in Drosophila melanogaster.
    Biogerontology 2018 Feb 15;19(1):1-12. Epub 2017 Sep 15.
    Max-Planck Odense Center on the Biodemography of Aging, Department of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9B, 5000, Odense C, Denmark.
    Studies examining how diet affects mortality risk over age typically characterise mortality using parameters such as aging rates, which condense how much and how quickly the risk of dying changes over time into a single measure. Demographers have suggested that decoupling the tempo and the magnitude of changing mortality risk may facilitate comparative analyses of mortality trajectories, but it is unclear what biologically meaningful information this approach offers. Here, we determine how the amount and ratio of protein and carbohydrate ingested by female Drosophila melanogaster affects how much mortality risk increases over a time-standardised life-course (the shape of aging) and the tempo at which animals live and die (the pace of aging). Read More

    How regularities of mortality statistics explain why we age despite having potentially ageless somatic stem cells.
    Biogerontology 2018 Feb 12;19(1):101-108. Epub 2017 Sep 12.
    Federal Research Center «Computer Science and Control» of the Russian Academy of Sciences, 44-2 Vavilov St., Moscow, Russia, 119333.
    Researchers working in the area of ageing have found numerous manifestations of this process at the molecular biological level, including DNA and protein damage, accumulation of metabolic by-products, lipids peroxidation, macromolecular cross-linking, non-enzymatic glycosylation, anti-oxidant/pro-oxidant misbalance, rising of pro-inflammatory cytokines, etc. This results in an increase in the proportion of cells in growth arrest, reduction of the rate of information processing, metabolic rate decrease, and decrease in rates of other processes characterizing dynamic aspects of the organism's interaction with its environment. Such staggering multilevel diversity in manifestation of senescence precludes (without methodology of systems biology) development of a correct understanding of its primary causes and does not allow for developing approaches capable of postponing ageing or reducing organisms' ageing rate to attain health preservation. Read More

    Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro.
    Biogerontology 2017 Oct 7;18(5):841-854. Epub 2017 Sep 7.
    Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
    Mild stress-induced activation of stress response (SR) pathways, such as autophagy, heat shock response, oxidative SR, DNA damage response, and inflammatory response, can be potentially health beneficial. Using the model system of cellular ageing and replicative senescence in vitro, we have studied the ageing modulatory effects of the two conditions, rapamycin and serum starvation. Chronic exposure to 0. Read More

    Senescence is not inevitable.
    Biogerontology 2017 Dec 28;18(6):965-971. Epub 2017 Aug 28.
    Max Planck Odense Center on the Biodemography of Aging, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
    Senescence, the physiological deterioration resulting in an increase in mortality and decline in fertility with age, is widespread in the animal kingdom and has often been regarded as an inescapable feature of all organisms. This essay briefly describes the history of the evolutionary theoretical ideas on senescence. The canonical evolutionary theories suggest that increasing mortality and decreasing fertility should be ubiquitous. Read More

    Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state.
    Biogerontology 2017 Oct 19;18(5):821-839. Epub 2017 Aug 19.
    Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
    To close the gap in our knowledge of sex influence on age-related changes in inflammation-oxidation state in spinal cord (SC) relevant to inflammation/oxidative-stress associated neuropathologies, 2-3 month-old (young) and 18-20 month-old (old) rats, exhibiting increased level of IL-6, a commonly used marker of inflamm-aging, were examined for inflammatory/redox status, and the underlying regulatory networks' molecules expression. With age, rat SC microglia became sensitized ("primed"), while SC tissue shifted towards mild inflammatory state, with increased levels of proinflammatory IL-1β (key marker of microglial systemic inflammation-induced neurotoxicity), which was more prominent in males. This, most likely, reflected age- and sex-related impairment in the expression of CX3CR1, the receptor for fractalkine (CX3CL1), the soluble factor which regulates microglial activation and diminishes production of IL-1β (central for fractalkine neuroprotection). Read More

    A genome-wide association study of cognitive function in Chinese adult twins.
    Biogerontology 2017 Oct 14;18(5):811-819. Epub 2017 Aug 14.
    Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
    Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world's largest and rapidly aging Chinese population. The paper aimed to identify the specific genetic variants associated with cognitive function in middle and old-aged Chinese dizygotic twins (DZ). Read More

    Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing.
    Biogerontology 2017 Dec 9;18(6):913-929. Epub 2017 Aug 9.
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UK.
    The field of the biology of ageing has received increasing attention from a biomedical point of view over the past decades. The main reason has been the realisation that increases in human population life expectancy are accompanied by late onset diseases. Indeed, ageing is the most important risk factor for a number of neoplastic, neurodegenerative and metabolic pathologies. Read More

    Reproduction, ageing, and longevity in two species of laboratory rodents with different life histories.
    Biogerontology 2017 Oct 24;18(5):803-809. Epub 2017 Jul 24.
    Institute of Systematics and Ecology of Animals, Siberian Branch of the Russian Academy of Sciences, Frunze Street 11, Novosibirsk, Russia, 630091.
    Social subterranean rodents of the Bathyergidae family are known to have extended longevity and some signs of negligible senescence, although the manifestation of these traits depends on the reproductive status of individuals. Such enormous life history peculiarities are usually explained by the specificity of a subterranean way of life. If so, all subterranean rodents, regardless of their taxonomic position, are expected to have higher maximum lifespans and shorter senescence periods than the related above-ground species. Read More

    Plant extracts and natural compounds used against UVB-induced photoaging.
    Biogerontology 2017 Aug 12;18(4):499-516. Epub 2017 Jul 12.
    Institute for Biomedical Aging Research, University of Innsbruck, Rennweg 10, 6020, Innsbruck, Austria.
    Skin is continuously exposed to a variety of environmental stresses, including ultraviolet (UV) radiation. UVB is an inherent component of sunlight that crosses the epidermis and reaches the upper dermis, leading to increased oxidative stress, activation of inflammatory response and accumulation of DNA damage among other effects. The increase in UVB radiation on earth due to the destruction of stratospheric ozone poses a major environmental threat to the skin, increasing the risk of damage with long-term consequences, such as photoaging and photocarcinogenesis. Read More

    A mild cold stress that increases resistance to heat lowers FOXO translocation in Drosophila melanogaster.
    Biogerontology 2017 Oct 4;18(5):791-801. Epub 2017 Jul 4.
    Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI Toulouse), Université de Toulouse, CNRS, UPS, Toulouse, France.
    Previous studies have shown that subjecting Drosophila melanogaster flies to a mild stress at young or middle age can increase lifespan and resistance to severe stresses throughout life and that the NF-κB-like transcription factor DIF, the 70 kDa heat-shock proteins, and the Drosophila Forkhead box class O (dFOXO) transcription factor could explain some of these effects. The present study showed that two dFOXO mutants do not survive longer heat if previously subjected to a mild cold stress, contrarily to wild-type flies. This cold pretreatment had nearly no effect on dFOXO nuclear translocation in wild-type males. Read More

    Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner.
    Biogerontology 2017 Aug 22;18(4):665-677. Epub 2017 Jun 22.
    Stem Cell Bioengineering Unit, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.
    Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Read More

    Aging effect on the instrumented Timed-Up-and-Go test variables in nursing home women aged 80-93 years.
    Biogerontology 2017 Aug 20;18(4):651-663. Epub 2017 Jun 20.
    The Jerzy Kukuczka Academy of Physical Education in Katowice, 72A Mikołowska Str., 40-065, Katowice, Poland.
    Although the total "Timed-Up-and Go" test (TUG) performance time can characterize an age-related decline of general mobility, this result alone doesn't give any detailed information about the test subtasks. The primary objective of the study was to identify in nursing home women a variable extracted from instrumented TUG (iTUG) that is the best predictor of age. The secondary objective was to assess whether this variable is associated with the results of the isometric knee extension peak torque (IKEPT); lower limb strength measured by the 30-s chair stand test (30sCST), and walking capacity measured by the 6-min walk test (6MWT). Read More

    Towards ageing well: Use it or lose it: Exercise, epigenetics and cognition.
    Biogerontology 2017 Aug 17;18(4):679-691. Epub 2017 Jun 17.
    School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Belfast, BT7 INN, Northern Ireland, UK.
    More and more people are living into the 90s or becoming centenarians. But, the gift of increased 'age span' seldom equates with an improved 'health-span'. Governments across the world are expressing concern about the epidemic of chronic disease, and have responded by initiating policies that make prevention, reduction and treatment of chronic disease, a public health priority. Read More

    Frailty phenotype and the role of levodopa challenge test in geriatric inpatients with mild parkinsonian signs.
    Biogerontology 2017 Aug 13;18(4):641-650. Epub 2017 Jun 13.
    John Paul II Geriatric Hospital, Research and Development Centre, Katowice, Poland.
    Deficiency in dopaminergic system function may be one of the hypothetical reasons of the frailty syndrome but its role still remains unclear. The aim of our study was to assess the frailty phenotype prevalence in geriatric inpatients with mild parkinsonian signs (MPS) and to investigate levodopa test in the frail patients with MPS. We examined 118 participants: 90 with MPS and 28 in control group (without MPS). Read More

    Resistance wheel exercise from mid-life has minimal effect on sciatic nerves from old mice in which sarcopenia was prevented.
    Biogerontology 2017 Oct 8;18(5):769-790. Epub 2017 Jun 8.
    School of Anatomy, Physiology and Human Biology, The University of Western Australia (UWA), Perth, WA, 6009, Australia.
    The ability of resistance exercise, initiated from mid-life, to prevent age-related changes in old sciatic nerves, was investigated in male and female C57BL/6J mice. Aging is associated with cellular changes in old sciatic nerves and also loss of skeletal muscle mass and function (sarcopenia). Mature adult mice aged 15 months (M) were subjected to increasing voluntary resistance wheel exercise (RWE) over a period of 8 M until 23 M of age. Read More

    Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.
    Biogerontology 2017 Aug 2;18(4):615-630. Epub 2017 Jun 2.
    Neurobiology and Molecular Chronobiology Laboratory, Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.
    Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels and daily pulses. To identify biomarkers of aging and PD chronomics of proteomic day-night profiles in suprachiasmatic nucleus (SCN), pineal and substantia nigra (SN) in 3 month (m), 12, 24 m and RIPD rat model were studied at two time points i. Read More

    Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans.
    Biogerontology 2017 Aug 1;18(4):485-497. Epub 2017 Jun 1.
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
    In evolutionary terms, life on the planet has taken the form of independently living cells for the majority of time. In comparison, the mammalian radiation is a relatively recent event. The common mammalian ancestor was probably small and short-lived. Read More

    The budding yeast Saccharomyces cerevisiae as a model organism: possible implications for gerontological studies.
    Biogerontology 2017 Aug 1;18(4):631-640. Epub 2017 Jun 1.
    Department of Biochemistry and Cell Biology, University of Rzeszow, Zelwerowicza 4, 35-601, Rzeszow, Poland.
    Experimental gerontology is based on the fundamental assumption that the aging process has a universal character and that the mechanisms of aging are well-conserved among living things. The consequence of this assumption is the use of various organisms, including unicellular yeast Saccharomyces cerevisiae, as models in gerontology, and direct extrapolation of the conclusions drawn from the studies carried on these organisms to human beings. However, numerous arguments suggest that aging is not universal and its mechanisms are not conserved in a wide range of species. Read More

    Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
    Biogerontology 2017 Dec 24;18(6):859-879. Epub 2017 May 24.
    Life & Health Sciences, Aston University, Birmingham, UK.
    Lipids are essential for physiological processes such as maintaining membrane integrity, providing a source of energy and acting as signalling molecules to control processes including cell proliferation, metabolism, inflammation and apoptosis. Disruption of lipid homeostasis can promote pathological changes that contribute towards biological ageing and age-related diseases. Several age-related diseases have been associated with altered lipid metabolism and an elevation in highly damaging lipid peroxidation products; the latter has been ascribed, at least in part, to mitochondrial dysfunction and elevated ROS formation. Read More

    Angiogenesis is VEGF-independent in the aged striatum of male rats exposed to acute hypoxia.
    Biogerontology 2017 Oct 13;18(5):759-768. Epub 2017 May 13.
    Department of Cell Biology, University of Granada, Avenida de la Fuentenueva s/n, 18071, Granada, Spain.
    Brain hypoxia is involved in many diseases. The activation of angiogenesis is one of the major adaptive mechanisms to counteract the adverse effects of hypoxia. In a previous work, we have shown that the adult rat striatum promotes angiogenesis in response to hypoxia via upregulation of the most important proangiogenic factor, the vascular endothelial growth factor (VEGF). Read More

    Influence of ageing on the microarchitecture of the spleen and lymph nodes.
    Biogerontology 2017 Oct 13;18(5):723-738. Epub 2017 May 13.
    The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, EH25 9RG, UK.
    The elderly have a decreased response to vaccination and an increased susceptibility to infectious diseases. The spleen and lymph nodes are important secondary lymphoid organs where immune cells can rapidly respond to pathogenic material in the blood and lymph in order to mount long-term adaptive immune responses to those pathogens. In aged mice and humans structural changes occur to both the spleen and lymph nodes. Read More

    Physical activity improves cognition: possible explanations.
    Biogerontology 2017 Aug 10;18(4):477-483. Epub 2017 May 10.
    Mediko, d.o.o., Višnja Gora, Slovenia.
    Good cognitive abilities (CA) enable autonomy, improve social inclusion and act preventively. Regular physical activity (PA) reduces the risk of developing Alzheimer's disease (AD) and, at the same time, it reduces the decline of CA and stimulates neurogenesis. So PA in connection with cognitive training, nutrition and social interaction has a positive effect on general CA and the central nervous system, the central executor, memory and attention, and reduces the likelihood of developing dementia. Read More

    Intermittent fasting combined with supplementation with Ayurvedic herbs reduces anxiety in middle aged female rats by anti-inflammatory pathways.
    Biogerontology 2017 Aug 6;18(4):601-614. Epub 2017 May 6.
    Medical Biotechnology Laboratory, Department of Biotechnology, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
    Intermittent fasting-dietary restriction (IF-DR) is an increasingly popular intervention to promote healthy aging and delay age associated decline in brain functions. Also, the use of herbal interventions is gaining attention due to their non-pharmacological approach to treat several abnormalities and promote general health with least side effects. The present study was aimed to investigate the synergistic effects of IF-DR regimen with herbal supplementation on anxiety-like behavior and neuroinflammation in middle aged female rats. Read More

    Exogenous nicotinamide supplementation and moderate physical exercise can attenuate the aging process in skeletal muscle of rats.
    Biogerontology 2017 Aug 5;18(4):593-600. Epub 2017 May 5.
    Research Institute of Sport Science, University of Physical Education, Alkotas u. 44, Budapest, 1123, Hungary.
    Nicotinamide (NAM) could enhance the availability of NADand be beneficial to cell function. However, NAM can inhibit the activities of SIRT1 and PARP. The effect of NAM supplementation on the aging process is not well known. Read More

    Tissue-specific transcription of the neuronal gene Lim3 affects Drosophila melanogaster lifespan and locomotion.
    Biogerontology 2017 Oct 2;18(5):739-757. Epub 2017 May 2.
    Institute of Molecular Genetics of the Russian Academy of Sciences, Kutchatov Sq. 2, Moscow, Russia, 123182.
    The identity of neuronal cell types is established and maintained by the expression of neuronal genes coding for ion channels, neurotransmitters, and neuropeptides, among others. Some of these genes have been shown to affect lifespan; however, their role in lifespan control remains largely unclear. The Drosophila melanogaster gene Lim3 encodes a transcription factor involved in complicated motor neuron specification networks. Read More

    Mifepristone/RU486 acts in Drosophila melanogaster females to counteract the life span-shortening and pro-inflammatory effects of male Sex Peptide.
    Biogerontology 2017 Jun 27;18(3):413-427. Epub 2017 Apr 27.
    Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, 1050 Childs Way, RRI201, Los Angeles, CA, 90089-2910, USA.
    Males with null mutation of Sex Peptide (SP) gene were compared to wild-type males for the ability to cause physiological changes in females that could be reversed by mifepristone. Males from wild-type strains decreased median female life span by average -51%. Feeding mifepristone increased life span of these females by average +106%. Read More

    The role of gender and labour status in immunosenescence of 65+ Polish population.
    Biogerontology 2017 Aug 25;18(4):581-590. Epub 2017 Apr 25.
    Laboratory of Molecular Bases of Aging, Department of Biochemistry, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur Str. 3, 02-093, Warsaw, Poland.
    Women are living longer than men and it seems that one of the reasons could be better immune system of females. In Poland, contrary to many European countries, women retire earlier than men, namely at 60 and 65, respectively. We asked the question how the gender and labour status were interconnected with some immunological parameters included in the so called immune risk profile (IRP), such as CD4+/CD8+ ratio, percentage of CD8+CD28-, and NK, and the level of circulating cytokines. Read More

    Intermittent food restriction initiated late in life prolongs lifespan and retards the onset of age-related markers in the annual fish Nothobranchius guentheri.
    Biogerontology 2017 Jun 21;18(3):383-396. Epub 2017 Apr 21.
    Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.
    Two of the most studied and widely accepted conjectures on possible aging mechanisms are the oxidative stress hypothesis and the insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) pathway. Intermittent fasting (IF) is known to modulate aging and to prolong lifespan in a variety of organisms, but the mechanisms are still under debate. In this study, we first demonstrated that late-onset two consecutive days a week fasting, a form of IF, termed intermittent food restriction (IFR), exhibited a time-dependent effect, and long-term late-onset IFR extended the mean lifespan and maximum lifespan by approximately 3. Read More

    Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia.
    Biogerontology 2017 Aug 18;18(4):561-580. Epub 2017 Apr 18.
    Department of Genetics, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957, Warsaw, Poland.
    The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer's disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined. In all-cause dementia adiponectin and resistin levels were significantly higher as compared to the controls; leptin levels did not show differences. Read More

    Hormetic efficacy of rutin to promote longevity in Drosophila melanogaster.
    Biogerontology 2017 Jun 7;18(3):397-411. Epub 2017 Apr 7.
    206, Structural Biology Lab, Centre for Biomedical Research, School of Bio Sciences & Technology, VIT University, Vellore, Tamil Nadu, India.
    Hormetins are compounds that mediate hormesis by being beneficial at low doses but detrimental at high doses. Recent studies have highlighted that many compounds that extended lifespan in model organisms did so by mediating hormesis. Rutin is a glycosylate conjugate of quercetin and rutinose and is abundant in citrus fruits and buckwheat seeds. Read More

    Measurement of muscle health in aging.
    Biogerontology 2017 Dec 4;18(6):901-911. Epub 2017 Apr 4.
    Human Science Research Unit, Center for Intervention in Inflammation, Infection and Immunity, University of Limerick, Limerick, Ireland.
    Muscle health is a critical component in the struggle against physical frailty and the efforts to maintain metabolic health until the limit of chronological age. Consensus opinion is to evaluate muscle health in terms of muscle mass, strength and functional capability. There has been considerable variability in the components of muscle health which have been investigated in addition to variability in the tools of assessment and protocol for measurement. Read More

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