1,060 results match your criteria Biogerontology[Journal]


Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP).

Biogerontology 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.

Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of age-related diseases, and there is growing interest in developing seno-modifying agents that can suppress the SASP. Read More

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http://dx.doi.org/10.1007/s10522-019-09796-4DOI Listing
February 2019

Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system.

Biogerontology 2019 Feb 6. Epub 2019 Feb 6.

Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, 266003, China.

One of the most studied and widely accepted conjectures of aging process is the oxidative stress theory. Current studies have generated disputes on the effects of GDF11 and GDF8, a closely related member of GDF11, on rejuvenation and anti-aging properties. In this study, we first demonstrated that when recombinant GDF8 (rGDF8) and GDF11 (rGDF11) of the fish Nothobranchius guentheri were injected into 20-month-old male mice, their serum GDF8 and GDF11 levels were clearly increased. Read More

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http://dx.doi.org/10.1007/s10522-019-09799-1DOI Listing
February 2019

Submandibular gland-specific inflammaging-induced hyposalivation in the male senescence-accelerated mouse prone -1 line (SAM-P1).

Biogerontology 2019 Jan 25. Epub 2019 Jan 25.

Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Fukuoka, 803-8580, Japan.

Aging has pronounced effects on mammalian tissues and cells, but the impacts of aging on salivary gland function are relatively unknown. This study aims to evaluate the effects of aging on submandibular gland (SMG) and parotid gland (PG) functions in the male senescence-accelerated mouse. In vivo analysis at the systemic level revealed that salivary secretion induced by pilocarpine, a muscarinic agonist, from the SMG was significantly decreased in aged mice, whereas salivary secretion from the PG was not affected. Read More

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http://dx.doi.org/10.1007/s10522-019-09797-3DOI Listing
January 2019

Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins.

Biogerontology 2019 Jan 21. Epub 2019 Jan 21.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.

Cell senescence, a state of cell cycle arrest and altered metabolism with enhanced pro-inflammatory secretion, underlies at least some aspects of organismal ageing. The sirtuin family of deacetylases has been implicated in preventing premature ageing; sirtuin overexpression or resveratrol-mediated activation of sirtuins increase longevity. Here we show that sirtuin inhibition by short-term, low-dose treatment with the experimental anti-cancer agent Tenovin-6 (TnV6) induces cellular senescence in primary human fibroblasts. Read More

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http://dx.doi.org/10.1007/s10522-018-09792-0DOI Listing
January 2019

Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases.

Biogerontology 2019 Jan 21. Epub 2019 Jan 21.

Department of Clinical Molecular Biology, Faculty of Medicine, University of Oslo, Oslo, Norway.

Aging is a natural and unavoidable part of life. However, aging is also the primary driver of the dominant human diseases, such as cardiovascular disease, cancer, and neurodegenerative diseases, including Alzheimer's disease. Unraveling the sophisticated molecular mechanisms of the human aging process may provide novel strategies to extend 'healthy aging' and the cure of human aging-related diseases. Read More

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http://link.springer.com/10.1007/s10522-019-09798-2
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http://dx.doi.org/10.1007/s10522-019-09798-2DOI Listing
January 2019
4 Reads
3.290 Impact Factor

Can markers of biological age predict dependency in old age?

Biogerontology 2019 Jan 21. Epub 2019 Jan 21.

The Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, 17 156, Stockholm, Sweden.

Recent research has shown that markers of biological age, such as leukocyte telomere length (LTL), epigenetic clocks and the frailty index (FI) are predictive of mortality and age-related diseases. However, whether these markers associate with the need for care in old age, thereby having utility in reflecting dependency, is unclear. This study was undertaken to analyze whether LTL, two epigenetic clocks-the DNA methylation age (DNAmAge) and DNAm PhenoAge-and the FI are associated with the need for regular care in up to 604 individuals (aged 48-94 years) participating in the Swedish Adoption/Twin Study of Aging. Read More

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http://dx.doi.org/10.1007/s10522-019-09795-5DOI Listing
January 2019
2 Reads

Therapeutic effects of curcumin on age-induced alterations in daily rhythms of clock genes and Sirt1 expression in the SCN of male Wistar rats.

Biogerontology 2019 Jan 3. Epub 2019 Jan 3.

Neurobiology and Molecular Chronobiology Laboratory, Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.

The aging brain is linked to accumulation of oxidative stress and increase in damage to biomolecules which in turn may cause or promote circadian dysfunction by disruption of biological clock, the suprachiasmatic nucleus (SCN). Age associated alterations in clock gene expression in the SCN has been reported earlier. In the present study we have examined therapeutic effects of the antioxidant curcumin on age induced alterations in daily rhythms and levels of core clock genes in SCN of young [3 months (m)], middle (12 months) and old (24 months) male Wistar rats. Read More

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http://dx.doi.org/10.1007/s10522-018-09794-yDOI Listing
January 2019
1 Read

Fecundity for free? Enhanced oviposition in longevous populations of Drosophila melanogaster.

Biogerontology 2019 Jan 3. Epub 2019 Jan 3.

Department of Ecology, Evolution, & Behavior, University of Minnesota Twin Cities, 1987 Upper Buford Circle, St. Paul, MN, 55108, USA.

Artificial selection for increased life span in experimental populations of Drosophila melanogaster sometimes produces long-lived populations that exhibit greater fecundity than unselected controls. The absence of a trade-off between survival and reproduction in these cases might be an artefact of the rich diet of typical lab culture; if nutritional resources are not limiting then there may be no need to trade off. Here I test the rich diet hypothesis by estimating genetic correlations between survival and age-specific fecundity in three nutritional environments. Read More

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http://dx.doi.org/10.1007/s10522-018-09791-1DOI Listing
January 2019
1 Read

Bridging the gap between the laboratory and the clinic for patients with sarcopenia.

Authors:
Miles D Witham

Biogerontology 2018 Dec 27. Epub 2018 Dec 27.

AGE Research Group, NIHR Newcastle Biomedical Research Centre, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle, NE4 5PL, UK.

Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a key goal for clinical ageing research. Read More

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http://link.springer.com/10.1007/s10522-018-09793-z
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http://dx.doi.org/10.1007/s10522-018-09793-zDOI Listing
December 2018
5 Reads

Both aging and exercise training alter the rate of recovery of neuromuscular performance of male soleus muscles.

Biogerontology 2018 Dec 17. Epub 2018 Dec 17.

Department of Kinesiology & Health Sciences, College of William & Mary, Williamsburg, VA, 23187-8795, USA.

It is known that both exercise and aging influence neuromuscular performance; however their effects on post-exercise recovery are largely unknown. To examine how exercise training and aging might affect post-exercise recovery, the function of muscles taken from young, and aged male rats assigned to exercise, or control conditions was assessed with ex vivo procedures using indirect (nerve endings), and direct (sarcolemma) stimulation at different times (Initial, Final min of, and Recovery i.e. Read More

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http://link.springer.com/10.1007/s10522-018-9788-y
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http://dx.doi.org/10.1007/s10522-018-9788-yDOI Listing
December 2018
5 Reads

Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri.

Biogerontology 2018 Dec 5. Epub 2018 Dec 5.

Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.

Current studies have generated disputes on the age-related change in the concentration of growth differentiation factor 11 (GDF11) and its role in the genesis of rejuvenation conditions. In this study we showed for the first time that both GDF11 gene expression and its protein abundance decreased with age in the fish Nothobranchius guentheri. We also showed that rGDF11 fed was indeed absorbed by the fish. Read More

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http://dx.doi.org/10.1007/s10522-018-09789-9DOI Listing
December 2018
2 Reads

L-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway.

Biogerontology 2018 Dec 5. Epub 2018 Dec 5.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, China.

Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in adipose tissue SASP and dysfunction. Read More

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http://dx.doi.org/10.1007/s10522-018-9787-zDOI Listing
December 2018
3 Reads
3.290 Impact Factor

Circadian clock genes' overexpression in Drosophila alters diet impact on lifespan.

Biogerontology 2018 Nov 24. Epub 2018 Nov 24.

Laboratory of Molecular Radiobiology and Gerontology, Komi Science Center, Institute of Biology, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya St., Syktyvkar, Komi Republic, Russian Federation, 167982.

Diet restriction is one of the most accurately confirmed interventions which extend lifespan. Genes coding circadian core clock elements are known to be the key controllers of cell metabolism especially in aging aspect. The molecular mechanisms standing behind the phenomenon of diet-restriction-mediated life extension are connected to circadian clock either. Read More

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http://dx.doi.org/10.1007/s10522-018-9784-2DOI Listing
November 2018
1 Read

Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway.

Biogerontology 2018 Nov 19. Epub 2018 Nov 19.

Pharmacology and Toxicology Laboratory, Food & Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, 176061, India.

The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information regarding the mechanistic role of EGCG in the suppression of cellular senescence is limited. The present study thus assessed the effects and underlying mechanisms of EGCG in the inhibition of senescence as well as its potential to selectively eliminate senescent cells (senolytics) using 3T3-L1 preadipocytes. Read More

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http://link.springer.com/10.1007/s10522-018-9785-1
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http://dx.doi.org/10.1007/s10522-018-9785-1DOI Listing
November 2018
17 Reads
3.290 Impact Factor

Larval crowding results in hormesis-like effects on longevity in Drosophila: timing of eclosion as a model.

Biogerontology 2018 Nov 19. Epub 2018 Nov 19.

D.F. Chebotarev State Institute of Gerontology, 67 Vyshgorodska, Kiev, 04114, Ukraine.

There is increasing evidence that stress during development can affect adult-life health status and longevity. In the present study, we examined life span (LS), fly weight, fecundity and expression levels of longevity-associated genes (Hsp70, InR, dSir2, dTOR and dFOXO) in adult Drosophila melanogaster flies reared in normal [low density (LD), ~ 300-400 eggs per jar] or crowded [high density (HD), more than 3000 eggs per jar] conditions by using the order (day) of emergence as an index of the developmental duration (HD1-5 groups). Developmental time showed a significant trend to increase while weight showed a significant trend to decrease with increasing the timing of emergence. Read More

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http://link.springer.com/10.1007/s10522-018-9786-0
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http://dx.doi.org/10.1007/s10522-018-9786-0DOI Listing
November 2018
2 Reads

Reproduction and mortality rates in ecologically distinct species of murid rodents.

Biogerontology 2018 Nov 11. Epub 2018 Nov 11.

Institute of Systematics and Ecology of Animals, Siberian Branch of the Russian Academy of Sciences, Frunze Street 11, Novosibirsk, Russia, 630091.

The trade-off between reproduction and somatic maintenance is one of the most studied concepts of modern evolutionary ecology. This theory predicts a negative relationship between maximum species longevity and total reproductive output. However, studies performed on natural animal populations have found contradictory results, probably due to the unlikelihood of wild animals gaining both maximum longevity and maximum potential fecundity. Read More

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http://dx.doi.org/10.1007/s10522-018-9783-3DOI Listing
November 2018
1 Read

Uropygial gland size: a marker of phenotypic quality that shows no senescence in a long-lived seabird.

Biogerontology 2018 Nov 10. Epub 2018 Nov 10.

Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 51014, Tartu, Estonia.

Studies of senescence in the wild have traditionally focused on traits like survival or fecundity. Although efforts to measure other salient phenotypic traits and markers of relevant physiological processes are rapidly increasing, traits related to self-maintenance remain understudied in the context of aging. Uropygial or preen gland is a holocrine gland, exclusive to birds, directly linked to self-maintenance of the quality of plumage. Read More

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http://link.springer.com/10.1007/s10522-018-9782-4
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http://dx.doi.org/10.1007/s10522-018-9782-4DOI Listing
November 2018
11 Reads

Extensive growth is followed by neurodegenerative pathology in the continuously expanding adult zebrafish retina.

Biogerontology 2019 Feb 31;20(1):109-125. Epub 2018 Oct 31.

Neural Circuit Development and Regeneration Research Group, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Naamsestraat 61, Box 2464, 3000, Leuven, Belgium.

The development of effective treatments for age-related neurodegenerative diseases remains one of the biggest medical challenges today, underscoring the high need for suitable animal model systems to improve our understanding of aging and age-associated neuropathology. Zebrafish have become an indispensable complementary model organism in gerontology research, yet their growth-control properties significantly differ from those in mammals. Here, we took advantage of the clearly defined and highly conserved structure of the fish retina to study the relationship between the processes of growth and aging in the adult zebrafish central nervous system (CNS). Read More

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http://dx.doi.org/10.1007/s10522-018-9780-6DOI Listing
February 2019
2 Reads

Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration?

Biogerontology 2018 Dec 29;19(6):497-517. Epub 2018 Oct 29.

Institute of Ageing and Chronic Disease, University of Liverpool, The William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK.

Human adult stem cell research is a highly prolific area in modern tissue engineering as these cells have significant potential to provide future cellular therapies for the world's increasingly aged population. Cellular therapies require a smart biomaterial to deliver and localise the cell population; protecting and guiding the stem cells toward predetermined lineage-specific pathways. The cells, in turn, can provide protection to biomaterials and increase its longevity. Read More

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http://link.springer.com/10.1007/s10522-018-9772-6
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http://dx.doi.org/10.1007/s10522-018-9772-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223734PMC
December 2018
2 Reads

Caloric restriction improves the redox homeostasis in the aging male rat heart even when started in middle-adulthood and when the body weight is stable.

Biogerontology 2019 Feb 29;20(1):127-140. Epub 2018 Oct 29.

Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Evidence indicates that maintenance of redox homeostasis is fundamental for cellular longevity. Caloric-restriction (CR) is said to decrease the formation of oxidatively modified cellular macromolecules and improve health. On the other hand, some studies indicate that many CR studies are flawed, because ad libitum fed rats are not well-controlled. Read More

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http://link.springer.com/10.1007/s10522-018-9781-5
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http://dx.doi.org/10.1007/s10522-018-9781-5DOI Listing
February 2019
10 Reads

Age-related changes in mitochondrial membrane composition of Nothobranchius furzeri.: comparison with a longer-living Nothobranchius species.

Biogerontology 2019 Feb 9;20(1):83-92. Epub 2018 Oct 9.

Chronobiology Lab, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, IUIE, IMIB-Arrixaca, Murcia, Spain.

Membrane compositions, particularly of mitochondria, could be critical factors in the mechanisms of growth and aging, especially during phases of high oxidative stress that result in molecular damage. Changes affecting lipid class or fatty acid (FA) compositions could affect phospholipid (PL) properties and alter mitochondrial function. In the present study, mitochondrial membrane PL compositions were analysed throughout the life-cycle of Nothobranchius furzeri, a species with explosive growth and one of the shortest-lived vertebrates. Read More

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http://link.springer.com/10.1007/s10522-018-9778-0
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http://dx.doi.org/10.1007/s10522-018-9778-0DOI Listing
February 2019
4 Reads

Dual roles of mitochondrial fusion gene FZO1 in yeast age asymmetry and in longevity mediated by a novel ATG32-dependent retrograde response.

Biogerontology 2019 Feb 8;20(1):93-107. Epub 2018 Oct 8.

Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave., MBC 8513, New Orleans, LA, 70112, USA.

The replicative lifespan of the yeast Saccharomyces cerevisiae models the aging of stem cells. Age asymmetry between the mother and daughter cells is established during each cell division, such that the daughter retains the capacity for self-renewal while this ability is diminished in the mother. The segregation of fully-functional mitochondria to daughter cells is one mechanism that underlies this age asymmetry. Read More

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http://link.springer.com/10.1007/s10522-018-9779-z
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http://dx.doi.org/10.1007/s10522-018-9779-zDOI Listing
February 2019
2 Reads

The biology of ageing and the omics revolution.

Biogerontology 2018 Dec 4;19(6):435-436. Epub 2018 Oct 4.

Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

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http://link.springer.com/10.1007/s10522-018-9776-2
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http://dx.doi.org/10.1007/s10522-018-9776-2DOI Listing
December 2018
2 Reads

Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice.

Biogerontology 2019 Feb 3;20(1):71-82. Epub 2018 Oct 3.

Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, 468-1, Aoba, Aramaki, Aoba-ku, Sendai, 980-0845, Japan.

This study used senescence-accelerated prone mice (SAMP8) to examine the effects of a carbohydrate-restricted diet on aging and skin senescence, to determine how long-term carbohydrate restriction affects the aging process. Three-week-old male SAMP8 mice were divided into three groups after 1 week of preliminary feeding: one was given a controlled diet, the other was given a high-fat diet, and the third was given a carbohydrate-restricted diet. Ad libitum feeding was administered until the mice reached 50 weeks of age. Read More

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http://link.springer.com/10.1007/s10522-018-9777-1
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http://dx.doi.org/10.1007/s10522-018-9777-1DOI Listing
February 2019
16 Reads

Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions.

Biogerontology 2018 Dec 29;19(6):481-496. Epub 2018 Sep 29.

MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, Birmingham University, Birmingham, UK.

It is widely accepted that ageing is accompanied by remodelling of the immune system, including reduced numbers of naïve T cells, increased senescent or exhausted T cells, compromise to monocyte, neutrophil and natural killer cell function and an increase in systemic inflammation. In combination these changes result in increased risk of infection, reduced immune memory, reduced immune tolerance and immune surveillance, with significant impacts upon health in old age. More recently it has become clear that the rate of decline in the immune system is malleable and can be influenced by environmental factors such as physical activity as well as pharmacological interventions. Read More

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http://link.springer.com/10.1007/s10522-018-9771-7
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http://dx.doi.org/10.1007/s10522-018-9771-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223743PMC
December 2018
7 Reads

Age-related changes in skeletal muscle: changes to life-style as a therapy.

Biogerontology 2018 Dec 27;19(6):519-536. Epub 2018 Sep 27.

Musculoskeletal Biology II, Institute of Ageing and Chronic Disease, Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, William Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK.

As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. Read More

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http://dx.doi.org/10.1007/s10522-018-9775-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223729PMC
December 2018
1 Read

Social environment improves immune function and redox state in several organs from prematurely aging female mice and increases their lifespan.

Biogerontology 2019 Feb 25;20(1):49-69. Epub 2018 Sep 25.

Department of Genetics, Physiology and Microbiology (Animal Physiology Unit), Faculty of Biology, Complutense University of Madrid (UCM), C/ José Antonio Novais, 12, 28040, Madrid, Spain.

Aging is associated with a chronic oxidative stress (increase of oxidants and decrease of antioxidants), which contributes to immunosenescence and therefore shorter longevity. Nevertheless, a positive social network has been related to the adequate maintenance of health and deceleration of aging. Adult prematurely aging mice (PAM) are characterized by their inadequate stress response to a T-maze, showing premature immunosenescence and oxidative stress establishment. Read More

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http://link.springer.com/10.1007/s10522-018-9774-4
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http://dx.doi.org/10.1007/s10522-018-9774-4DOI Listing
February 2019
3 Reads

Metformin as a geroprotector: experimental and clinical evidence.

Biogerontology 2019 Feb 25;20(1):33-48. Epub 2018 Sep 25.

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.

Apart from being a safe, effective and globally affordable glucose-lowering agent for the treatment of diabetes, metformin has earned much credit in recent years as a potential anti-aging formula. It has been shown to significantly increase lifespan and delay the onset of age-associated decline in several experimental models. The current review summarizes advances in clinical research on the potential role of metformin in the field of geroprotection, highlighting findings from pre-clinical studies on known and putative mechanisms behind its beneficial properties. Read More

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http://link.springer.com/10.1007/s10522-018-9773-5
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http://dx.doi.org/10.1007/s10522-018-9773-5DOI Listing
February 2019
20 Reads
3.290 Impact Factor

Amino acids and amino acid sensing: implication for aging and diseases.

Biogerontology 2019 Feb 25;20(1):17-31. Epub 2018 Sep 25.

Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036, Rende, Italy.

Biogerontological research indicates nutrition as one of the major determinants of healthy aging, due to the role of nutrients in maintaining the dynamic-homeostasis of the organism. In this frame, the importance of proteins and constitutive amino acids (AAs), and in particular of functional AAs is emerging. The ability to sense and respond to changes in AAs availability is mediated by a complex network of dynamic players, crucial for an efficient regulation of their downstream effects. Read More

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http://link.springer.com/10.1007/s10522-018-9770-8
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http://dx.doi.org/10.1007/s10522-018-9770-8DOI Listing
February 2019
8 Reads

Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction.

Biogerontology 2019 Feb 18;20(1):1-16. Epub 2018 Sep 18.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.

Aging is a biological process characterized by a progressive functional decline in tissues and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat sequences at the end of linear eukaryotic chromosomes protecting chromosome ends from degradation and illegitimate recombination, play a crucial role in cell fate and aging. Due to the mechanism of replication, telomeres shorten as cells proliferate, which consequently contributes to cellular senescence and mitochondrial dysfunction. Read More

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http://dx.doi.org/10.1007/s10522-018-9769-1DOI Listing
February 2019
2 Reads

Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?

Biogerontology 2018 Dec 24;19(6):461-480. Epub 2018 Aug 24.

Centro Andaluz de Biología del Desarrollo, CABD-CSIC, CIBERER, Instituto de Salud Carlos III, Universidad Pablo de Olavide, Carretera de Utrera km. 1, 41013, Seville, Spain.

Mitochondria are key in the metabolism of aerobic organisms and in ageing progression and age-related diseases. Mitochondria are essential for obtaining ATP from glucose and fatty acids but also in many other essential functions in cells including aminoacids metabolism, pyridine synthesis, phospholipid modifications and calcium regulation. On the other hand, the activity of mitochondria is also the principal source of reactive oxygen species in cells. Read More

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http://dx.doi.org/10.1007/s10522-018-9768-2DOI Listing
December 2018
13 Reads
3.290 Impact Factor

Detecting senescent fate in mesenchymal stem cells: a combined cytofluorimetric and ultrastructural approach.

Biogerontology 2018 10 12;19(5):401-414. Epub 2018 Aug 12.

Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Via Tronto 10/a, 60126, Ancona, Italy.

Senescence can impair the therapeutic potential of stem cells. In this study, senescence-associated morphofunctional changes in periosteum-derived progenitor cells (PDPCs) from old and young individuals were investigated by combining cytofluorimetry, immunohistochemistry, and transmission electron microscopy. Cell cycle analysis demonstrated a large number of G0/G1 phase cells in PDPCs from old subjects and a progressive accumulation of G0/G1 cells during passaging in cultures from young subjects. Read More

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http://dx.doi.org/10.1007/s10522-018-9766-4DOI Listing
October 2018
2 Reads

The secretory phenotype of senescent astrocytes isolated from Wistar newborn rats changes with anti-inflammatory drugs, but does not have a short-term effect on neuronal mitochondrial potential.

Biogerontology 2018 10 10;19(5):415-433. Epub 2018 Aug 10.

División de Ciencias Biológicas y de la Salud, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P. 09340, Ciudad de México, Mexico.

In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescence inducer and time. Read More

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http://dx.doi.org/10.1007/s10522-018-9767-3DOI Listing
October 2018
8 Reads

Age-related loss of VGLUT1 excitatory, but not VGAT inhibitory, immunoreactive terminals on motor neurons in spinal cords of old sarcopenic male mice.

Biogerontology 2018 10 6;19(5):385-399. Epub 2018 Aug 6.

School of Human Sciences, The University of Western Australia, Perth, WA, 6009, Australia.

Age-related changes in ventral lumbar spinal cord (L3-L5) were compared in young [3 month, (M)] and old (27 M) C57BL/6J male mice. The aged mice had previously been shown to exhibit sarcopenia and changes to peripheral nerve morphology. The putative connectivity of β-III tubulin positive α-motor neurons was compared in immunostained transverse sections using excitatory and inhibitory terminal markers vesicular glutamate transporter-1 (VGLUT1) and vesicular GABA transporter (VGAT). Read More

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http://dx.doi.org/10.1007/s10522-018-9765-5DOI Listing
October 2018
4 Reads

The effect of dietary lipid on gut microbiota in a senescence-accelerated prone mouse model (SAMP8).

Biogerontology 2018 10 2;19(5):367-383. Epub 2018 Aug 2.

Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, 468-1, Aoba, Aramaki, Aoba-ku, Sendai, 980-0845, Japan.

Gut microbiota change with aging and diet. In a previous study, it was shown that a moderate-fat diet enriched with fish oil had beneficial effects for elderly patients, so we examined the effect of this diet on aging-related changes in gut microbiota in this study. We used 3-month-old male senescence-accelerated prone mice (SAMP8). Read More

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http://dx.doi.org/10.1007/s10522-018-9764-6DOI Listing
October 2018
2 Reads

Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing.

Biogerontology 2018 Dec 27;19(6):447-459. Epub 2018 Jul 27.

School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Moulsecoomb, Brighton, BN2 4GJ, UK.

Cellular senescence is now considered as a major mechanism in the development and progression of various diseases and this may include metabolic diseases such as obesity and type-2 diabetes. The presence of obesity and diabetes is a major risk factor in the development of additional health conditions, such as cardiovascular disease, kidney disease and cancer. Since senescent cells can drive disease development, obesity and diabetes can potentially create an environment that accelerates cell senescence within other tissues of the body. Read More

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http://dx.doi.org/10.1007/s10522-018-9763-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223730PMC
December 2018
3 Reads
3.290 Impact Factor

Peroxisomes: role in cellular ageing and age related disorders.

Biogerontology 2018 10 2;19(5):303-324. Epub 2018 Jul 2.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.

Peroxisomes are dynamic organelles essential for optimum functioning of a eukaryotic cell. Biogenesis of these organelles and the diverse functions performed by them have been extensively studied in the past decade. Their ability to perform functions depending on the cell type and growth conditions is unique and remarkable. Read More

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http://dx.doi.org/10.1007/s10522-018-9761-9DOI Listing
October 2018
12 Reads

Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence.

Biogerontology 2018 10 29;19(5):325-339. Epub 2018 Jun 29.

Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

The aging process is associated with a low-grade chronic inflammation and the accumulation of senescent cells into tissues. Diverse stresses can trigger cellular senescence, a cell fate characterized by cell-cycle arrest and flat morphology. Oncogenic signaling can also induce cellular senescence which has been termed oncogene-induced senescence (OIS). Read More

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http://dx.doi.org/10.1007/s10522-018-9762-8DOI Listing
October 2018
20 Reads

In memoriam Ladislas Robert (1924-2018).

Authors:
Tamas Fulop

Biogerontology 2018 Jul;19(3-4):185-187

Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada.

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http://dx.doi.org/10.1007/s10522-018-9760-xDOI Listing
July 2018
3 Reads

Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.

Biogerontology 2018 Dec 15;19(6):579-602. Epub 2018 Jun 15.

Progeria Research Team, Healthy Ageing Theme, Institute for Environment, Health and Societies, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, UB8 3PH, UK.

Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal premature ageing disease in children. HGPS is one of several progeroid syndromes caused by mutations in the LMNA gene encoding the nuclear structural proteins lamins A and C. In classic HGPS the mutation G608G leads to the formation of a toxic lamin A protein called progerin. Read More

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http://link.springer.com/10.1007/s10522-018-9758-4
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http://dx.doi.org/10.1007/s10522-018-9758-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223735PMC
December 2018
12 Reads
3.290 Impact Factor

Applying parametric models to survival data: tradeoffs between statistical significance, biological plausibility, and common sense.

Biogerontology 2018 10 4;19(5):341-365. Epub 2018 Jun 4.

N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg, 197758, Russia.

Parametric models for survival data help to differentiate aging from other lifespan determinants. However, such inferences suffer from small sizes of experimental animal samples and variable animals handling by different labs. We analyzed control data from a single laboratory where interventions in murine lifespan were studied over decades. Read More

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http://dx.doi.org/10.1007/s10522-018-9759-3DOI Listing
October 2018
4 Reads

Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells.

Biogerontology 2018 07 26;19(3-4):287-301. Epub 2018 May 26.

Laboratory of bioengineering and regenerative medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave, Astana, Kazakhstan, Z05H0P9.

Mesenchymal stem cells (MSCs) represent a promising cell source for cellular therapy and tissue engineering and are currently being tested in a number of clinical trials for various diseases. However, like other somatic cells, MSCs age, and this senescence is accompanied by a progressive decline in stem cell function. Several lines of evidence suggest a role for the Rho family GTPase Cdc42 activity in cellular senescence processes. Read More

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http://dx.doi.org/10.1007/s10522-018-9757-5DOI Listing
July 2018
5 Reads

Mitigating peroxynitrite mediated mitochondrial dysfunction in aged rat brain by mitochondria-targeted antioxidant MitoQ.

Biogerontology 2018 07 17;19(3-4):271-286. Epub 2018 May 17.

Department of Zoology, University of Kalyani, Kalyani, West Bengal, 741235, India.

Although reactive oxygen species mediated oxidative stress is a well-documented mechanism of aging, recent evidences indicate involvement of nitrosative stress in the same. As mitochondrial dysfunction is considered as one of the primary features of aging, the present study was designed to understand the involvement of nitrosative stress by studying the impact of a mitochondria-targeted antioxidant MitoQ, a peroxynitrite (ONOO) scavenger, on mitochondrial functions. Four groups of rats were included in this study: Group I: Young-6 months (-MitoQ), Group II: Aged-22 months (- MitoQ), Group III: Young-6 months (+ MitoQ), Group IV: Aged-22 months (+ MitoQ). Read More

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http://link.springer.com/10.1007/s10522-018-9756-6
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http://dx.doi.org/10.1007/s10522-018-9756-6DOI Listing
July 2018
8 Reads
3.290 Impact Factor

Mechanics of population aging and survival.

Biogerontology 2018 07 10;19(3-4):251-269. Epub 2018 May 10.

Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, 23284-2030, USA.

In this paper we extend the previous work of Witten and her team on defining a classical physics-driven model of survival in aging populations (Eakin, Bull Math Biol 56(6):1121-1141, 1994; Eakin and Witten, Mech Aging Dev 78(2):85-101, 1995; Witten and Eakin, Exp Gerontol 32(2):259-285, 1997) by revisiting the concept of a force of aging and introducing the concepts of a momentum of aging, a kinetic energy and a potential energy of an aging population. We further extend the analysis beyond the deterministic Newtonian mechanics of a macroscopic population as a whole by considering the probabilistic nature of survival of individual population cohort members, thus producing new statistical physics-based concepts of entropy and of a gerontological "temperature". These new concepts are then illustrated with application to the classic parametric Gompertz survival model, which is a commonly used empirical descriptor for survival dynamics of mammalian species, human populations in particular. Read More

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http://dx.doi.org/10.1007/s10522-018-9755-7DOI Listing
July 2018
7 Reads

The impact of aging on CD4 T cell responses to influenza infection.

Biogerontology 2018 Dec 3;19(6):437-446. Epub 2018 Apr 3.

UConn Center on Aging and Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, 06030, USA.

CD4 T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4 T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearance and prolonged inflammation leading to increased pathology. Current research employing animal models and human subjects has provided new insights into the description and mechanisms of age-related CD4 T cell changes. Read More

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http://dx.doi.org/10.1007/s10522-018-9754-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170716PMC
December 2018
10 Reads

Long-term exposure to TNF-α leads human skin fibroblasts to a p38 MAPK- and ROS-mediated premature senescence.

Biogerontology 2018 07 26;19(3-4):237-249. Epub 2018 Mar 26.

Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", 153 10, Athens, Greece.

Tumor necrosis factor α (TNF-α) is an inflammatory mediator overexpressed in the skin as a response to ultraviolet radiation, as well as in chronic non-healing wounds. On the other hand, senescent fibroblasts have been shown to accumulate in the skin under these stressful conditions. Accordingly, here we assessed the putative implication of TNF-α in the induction of premature senescence of human adult dermal fibroblasts. Read More

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http://dx.doi.org/10.1007/s10522-018-9753-9DOI Listing
July 2018
15 Reads

Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model system.

Authors:
Marina Ezcurra

Biogerontology 2018 Dec 19;19(6):567-578. Epub 2018 Mar 19.

Department of Genetics, Evolution and Environment and Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK.

High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complexity and heterogeneity of the human microbiome we need robust experimental models that allow the systematic manipulation of variables to test the multitude of hypotheses arisen from large-scale 'meta-omic' projects. Read More

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http://dx.doi.org/10.1007/s10522-018-9752-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223720PMC
December 2018
6 Reads

A review of telomere length in sarcopenia and frailty.

Biogerontology 2018 07 16;19(3-4):209-221. Epub 2018 Mar 16.

Department of Geriatrics, Neurosciences and Orthopedics, A. Gemelli Foundation, Catholic University of the Sacred Heart, School of Medicine, L.go F. Vito 1, 00168, Rome, Italy.

Sarcopenia and frailty are associated with several important health-related adverse events, including disability, loss of independence, institutionalization and mortality. Sarcopenia can be considered a biological substrate of frailty, and the prevalence of both these conditions progressively increases with age. Telomeres are nucleoprotein structures located at the end of linear chromosomes and implicated in cellular ageing, shorten with age, and are associated with various age-related diseases. Read More

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http://dx.doi.org/10.1007/s10522-018-9749-5DOI Listing
July 2018
5 Reads

Involvement of the autophagic pathway in the progression of AMD-like retinopathy in senescence-accelerated OXYS rats.

Biogerontology 2018 07 28;19(3-4):223-235. Epub 2018 Feb 28.

Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia.

Age-related macular degeneration (AMD) is a complex neurodegenerative disease resulting in a loss of central vision in the elderly. It is currently assumed that impairment of autophagy may be one of the key mechanisms leading to AMD. Here we estimated the influence of age-related autophagy alterations in the retina on the development of AMD-like retinopathy in senescence-accelerated OXYS rats. Read More

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http://dx.doi.org/10.1007/s10522-018-9751-yDOI Listing
July 2018
5 Reads

Gene expression hallmarks of cellular ageing.

Biogerontology 2018 Dec 28;19(6):547-566. Epub 2018 Feb 28.

Epigenetics Programme, Babraham Institute, Cambridge, UK.

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven by highly conserved cell intrinsic processes, and a set of unifying hallmarks of ageing has been defined. Here, we survey reports of age-linked changes in basal gene expression across eukaryotes from yeast to human and identify six gene expression hallmarks of cellular ageing: downregulation of genes encoding mitochondrial proteins; downregulation of the protein synthesis machinery; dysregulation of immune system genes; reduced growth factor signalling; constitutive responses to stress and DNA damage; dysregulation of gene expression and mRNA processing. Read More

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http://dx.doi.org/10.1007/s10522-018-9750-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223719PMC
December 2018
5 Reads