1,050 results match your criteria Biogerontology[Journal]


Late-onset administration of GDF11 extends life span and delays development of age-related markers in the annual fish Nothobranchius guentheri.

Biogerontology 2018 Dec 5. Epub 2018 Dec 5.

Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China.

Current studies have generated disputes on the age-related change in the concentration of growth differentiation factor 11 (GDF11) and its role in the genesis of rejuvenation conditions. In this study we showed for the first time that both GDF11 gene expression and its protein abundance decreased with age in the fish Nothobranchius guentheri. We also showed that rGDF11 fed was indeed absorbed by the fish. Read More

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December 2018

L-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway.

Biogerontology 2018 Dec 5. Epub 2018 Dec 5.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, China.

Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in adipose tissue SASP and dysfunction. Read More

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December 2018

Circadian clock genes' overexpression in Drosophila alters diet impact on lifespan.

Biogerontology 2018 Nov 24. Epub 2018 Nov 24.

Laboratory of Molecular Radiobiology and Gerontology, Komi Science Center, Institute of Biology, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya St., Syktyvkar, Komi Republic, Russian Federation, 167982.

Diet restriction is one of the most accurately confirmed interventions which extend lifespan. Genes coding circadian core clock elements are known to be the key controllers of cell metabolism especially in aging aspect. The molecular mechanisms standing behind the phenomenon of diet-restriction-mediated life extension are connected to circadian clock either. Read More

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November 2018

Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway.

Biogerontology 2018 Nov 19. Epub 2018 Nov 19.

Pharmacology and Toxicology Laboratory, Food & Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, 176061, India.

The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information regarding the mechanistic role of EGCG in the suppression of cellular senescence is limited. The present study thus assessed the effects and underlying mechanisms of EGCG in the inhibition of senescence as well as its potential to selectively eliminate senescent cells (senolytics) using 3T3-L1 preadipocytes. Read More

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November 2018
4 Reads

Larval crowding results in hormesis-like effects on longevity in Drosophila: timing of eclosion as a model.

Biogerontology 2018 Nov 19. Epub 2018 Nov 19.

D.F. Chebotarev State Institute of Gerontology, 67 Vyshgorodska, Kiev, 04114, Ukraine.

There is increasing evidence that stress during development can affect adult-life health status and longevity. In the present study, we examined life span (LS), fly weight, fecundity and expression levels of longevity-associated genes (Hsp70, InR, dSir2, dTOR and dFOXO) in adult Drosophila melanogaster flies reared in normal [low density (LD), ~ 300-400 eggs per jar] or crowded [high density (HD), more than 3000 eggs per jar] conditions by using the order (day) of emergence as an index of the developmental duration (HD1-5 groups). Developmental time showed a significant trend to increase while weight showed a significant trend to decrease with increasing the timing of emergence. Read More

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November 2018

Reproduction and mortality rates in ecologically distinct species of murid rodents.

Biogerontology 2018 Nov 11. Epub 2018 Nov 11.

Institute of Systematics and Ecology of Animals, Siberian Branch of the Russian Academy of Sciences, Frunze Street 11, Novosibirsk, Russia, 630091.

The trade-off between reproduction and somatic maintenance is one of the most studied concepts of modern evolutionary ecology. This theory predicts a negative relationship between maximum species longevity and total reproductive output. However, studies performed on natural animal populations have found contradictory results, probably due to the unlikelihood of wild animals gaining both maximum longevity and maximum potential fecundity. Read More

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November 2018

Uropygial gland size: a marker of phenotypic quality that shows no senescence in a long-lived seabird.

Biogerontology 2018 Nov 10. Epub 2018 Nov 10.

Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 51014, Tartu, Estonia.

Studies of senescence in the wild have traditionally focused on traits like survival or fecundity. Although efforts to measure other salient phenotypic traits and markers of relevant physiological processes are rapidly increasing, traits related to self-maintenance remain understudied in the context of aging. Uropygial or preen gland is a holocrine gland, exclusive to birds, directly linked to self-maintenance of the quality of plumage. Read More

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November 2018
4 Reads

Extensive growth is followed by neurodegenerative pathology in the continuously expanding adult zebrafish retina.

Biogerontology 2018 Oct 31. Epub 2018 Oct 31.

Neural Circuit Development and Regeneration Research Group, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Naamsestraat 61, Box 2464, 3000, Leuven, Belgium.

The development of effective treatments for age-related neurodegenerative diseases remains one of the biggest medical challenges today, underscoring the high need for suitable animal model systems to improve our understanding of aging and age-associated neuropathology. Zebrafish have become an indispensable complementary model organism in gerontology research, yet their growth-control properties significantly differ from those in mammals. Here, we took advantage of the clearly defined and highly conserved structure of the fish retina to study the relationship between the processes of growth and aging in the adult zebrafish central nervous system (CNS). Read More

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October 2018
1 Read

Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration?

Biogerontology 2018 Dec 29;19(6):497-517. Epub 2018 Oct 29.

Institute of Ageing and Chronic Disease, University of Liverpool, The William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK.

Human adult stem cell research is a highly prolific area in modern tissue engineering as these cells have significant potential to provide future cellular therapies for the world's increasingly aged population. Cellular therapies require a smart biomaterial to deliver and localise the cell population; protecting and guiding the stem cells toward predetermined lineage-specific pathways. The cells, in turn, can provide protection to biomaterials and increase its longevity. Read More

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December 2018
1 Read

Caloric restriction improves the redox homeostasis in the aging male rat heart even when started in middle-adulthood and when the body weight is stable.

Biogerontology 2018 Oct 29. Epub 2018 Oct 29.

Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Evidence indicates that maintenance of redox homeostasis is fundamental for cellular longevity. Caloric-restriction (CR) is said to decrease the formation of oxidatively modified cellular macromolecules and improve health. On the other hand, some studies indicate that many CR studies are flawed, because ad libitum fed rats are not well-controlled. Read More

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October 2018
4 Reads

Age-related changes in mitochondrial membrane composition of Nothobranchius furzeri.: comparison with a longer-living Nothobranchius species.

Biogerontology 2018 Oct 9. Epub 2018 Oct 9.

Chronobiology Lab, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, IUIE, IMIB-Arrixaca, Murcia, Spain.

Membrane compositions, particularly of mitochondria, could be critical factors in the mechanisms of growth and aging, especially during phases of high oxidative stress that result in molecular damage. Changes affecting lipid class or fatty acid (FA) compositions could affect phospholipid (PL) properties and alter mitochondrial function. In the present study, mitochondrial membrane PL compositions were analysed throughout the life-cycle of Nothobranchius furzeri, a species with explosive growth and one of the shortest-lived vertebrates. Read More

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October 2018
1 Read

Dual roles of mitochondrial fusion gene FZO1 in yeast age asymmetry and in longevity mediated by a novel ATG32-dependent retrograde response.

Biogerontology 2018 Oct 8. Epub 2018 Oct 8.

Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave., MBC 8513, New Orleans, LA, 70112, USA.

The replicative lifespan of the yeast Saccharomyces cerevisiae models the aging of stem cells. Age asymmetry between the mother and daughter cells is established during each cell division, such that the daughter retains the capacity for self-renewal while this ability is diminished in the mother. The segregation of fully-functional mitochondria to daughter cells is one mechanism that underlies this age asymmetry. Read More

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October 2018
1 Read

The biology of ageing and the omics revolution.

Biogerontology 2018 Dec 4;19(6):435-436. Epub 2018 Oct 4.

Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

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December 2018
1 Read

Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice.

Biogerontology 2018 Oct 3. Epub 2018 Oct 3.

Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, 468-1, Aoba, Aramaki, Aoba-ku, Sendai, 980-0845, Japan.

This study used senescence-accelerated prone mice (SAMP8) to examine the effects of a carbohydrate-restricted diet on aging and skin senescence, to determine how long-term carbohydrate restriction affects the aging process. Three-week-old male SAMP8 mice were divided into three groups after 1 week of preliminary feeding: one was given a controlled diet, the other was given a high-fat diet, and the third was given a carbohydrate-restricted diet. Ad libitum feeding was administered until the mice reached 50 weeks of age. Read More

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October 2018
7 Reads

Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions.

Biogerontology 2018 Dec 29;19(6):481-496. Epub 2018 Sep 29.

MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, Birmingham University, Birmingham, UK.

It is widely accepted that ageing is accompanied by remodelling of the immune system, including reduced numbers of naïve T cells, increased senescent or exhausted T cells, compromise to monocyte, neutrophil and natural killer cell function and an increase in systemic inflammation. In combination these changes result in increased risk of infection, reduced immune memory, reduced immune tolerance and immune surveillance, with significant impacts upon health in old age. More recently it has become clear that the rate of decline in the immune system is malleable and can be influenced by environmental factors such as physical activity as well as pharmacological interventions. Read More

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December 2018
5 Reads

Age-related changes in skeletal muscle: changes to life-style as a therapy.

Biogerontology 2018 Dec 27;19(6):519-536. Epub 2018 Sep 27.

Musculoskeletal Biology II, Institute of Ageing and Chronic Disease, Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, William Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK.

As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. Read More

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December 2018

Social environment improves immune function and redox state in several organs from prematurely aging female mice and increases their lifespan.

Biogerontology 2018 Sep 25. Epub 2018 Sep 25.

Department of Genetics, Physiology and Microbiology (Animal Physiology Unit), Faculty of Biology, Complutense University of Madrid (UCM), C/ José Antonio Novais, 12, 28040, Madrid, Spain.

Aging is associated with a chronic oxidative stress (increase of oxidants and decrease of antioxidants), which contributes to immunosenescence and therefore shorter longevity. Nevertheless, a positive social network has been related to the adequate maintenance of health and deceleration of aging. Adult prematurely aging mice (PAM) are characterized by their inadequate stress response to a T-maze, showing premature immunosenescence and oxidative stress establishment. Read More

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September 2018
2 Reads

Metformin as a geroprotector: experimental and clinical evidence.

Biogerontology 2018 Sep 25. Epub 2018 Sep 25.

Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.

Apart from being a safe, effective and globally affordable glucose-lowering agent for the treatment of diabetes, metformin has earned much credit in recent years as a potential anti-aging formula. It has been shown to significantly increase lifespan and delay the onset of age-associated decline in several experimental models. The current review summarizes advances in clinical research on the potential role of metformin in the field of geroprotection, highlighting findings from pre-clinical studies on known and putative mechanisms behind its beneficial properties. Read More

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September 2018
12 Reads
3.290 Impact Factor

Amino acids and amino acid sensing: implication for aging and diseases.

Biogerontology 2018 Sep 25. Epub 2018 Sep 25.

Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036, Rende, Italy.

Biogerontological research indicates nutrition as one of the major determinants of healthy aging, due to the role of nutrients in maintaining the dynamic-homeostasis of the organism. In this frame, the importance of proteins and constitutive amino acids (AAs), and in particular of functional AAs is emerging. The ability to sense and respond to changes in AAs availability is mediated by a complex network of dynamic players, crucial for an efficient regulation of their downstream effects. Read More

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September 2018
1 Read

Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction.

Biogerontology 2018 Sep 18. Epub 2018 Sep 18.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.

Aging is a biological process characterized by a progressive functional decline in tissues and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat sequences at the end of linear eukaryotic chromosomes protecting chromosome ends from degradation and illegitimate recombination, play a crucial role in cell fate and aging. Due to the mechanism of replication, telomeres shorten as cells proliferate, which consequently contributes to cellular senescence and mitochondrial dysfunction. Read More

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September 2018

Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?

Biogerontology 2018 Dec 24;19(6):461-480. Epub 2018 Aug 24.

Centro Andaluz de Biología del Desarrollo, CABD-CSIC, CIBERER, Instituto de Salud Carlos III, Universidad Pablo de Olavide, Carretera de Utrera km. 1, 41013, Seville, Spain.

Mitochondria are key in the metabolism of aerobic organisms and in ageing progression and age-related diseases. Mitochondria are essential for obtaining ATP from glucose and fatty acids but also in many other essential functions in cells including aminoacids metabolism, pyridine synthesis, phospholipid modifications and calcium regulation. On the other hand, the activity of mitochondria is also the principal source of reactive oxygen species in cells. Read More

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December 2018
6 Reads
3.290 Impact Factor

Detecting senescent fate in mesenchymal stem cells: a combined cytofluorimetric and ultrastructural approach.

Biogerontology 2018 10 12;19(5):401-414. Epub 2018 Aug 12.

Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Via Tronto 10/a, 60126, Ancona, Italy.

Senescence can impair the therapeutic potential of stem cells. In this study, senescence-associated morphofunctional changes in periosteum-derived progenitor cells (PDPCs) from old and young individuals were investigated by combining cytofluorimetry, immunohistochemistry, and transmission electron microscopy. Cell cycle analysis demonstrated a large number of G0/G1 phase cells in PDPCs from old subjects and a progressive accumulation of G0/G1 cells during passaging in cultures from young subjects. Read More

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October 2018
1 Read

The secretory phenotype of senescent astrocytes isolated from Wistar newborn rats changes with anti-inflammatory drugs, but does not have a short-term effect on neuronal mitochondrial potential.

Biogerontology 2018 10 10;19(5):415-433. Epub 2018 Aug 10.

División de Ciencias Biológicas y de la Salud, Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, C.P. 09340, Ciudad de México, Mexico.

In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescence inducer and time. Read More

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October 2018
2 Reads

Age-related loss of VGLUT1 excitatory, but not VGAT inhibitory, immunoreactive terminals on motor neurons in spinal cords of old sarcopenic male mice.

Biogerontology 2018 10 6;19(5):385-399. Epub 2018 Aug 6.

School of Human Sciences, The University of Western Australia, Perth, WA, 6009, Australia.

Age-related changes in ventral lumbar spinal cord (L3-L5) were compared in young [3 month, (M)] and old (27 M) C57BL/6J male mice. The aged mice had previously been shown to exhibit sarcopenia and changes to peripheral nerve morphology. The putative connectivity of β-III tubulin positive α-motor neurons was compared in immunostained transverse sections using excitatory and inhibitory terminal markers vesicular glutamate transporter-1 (VGLUT1) and vesicular GABA transporter (VGAT). Read More

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October 2018
1 Read

The effect of dietary lipid on gut microbiota in a senescence-accelerated prone mouse model (SAMP8).

Biogerontology 2018 10 2;19(5):367-383. Epub 2018 Aug 2.

Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, 468-1, Aoba, Aramaki, Aoba-ku, Sendai, 980-0845, Japan.

Gut microbiota change with aging and diet. In a previous study, it was shown that a moderate-fat diet enriched with fish oil had beneficial effects for elderly patients, so we examined the effect of this diet on aging-related changes in gut microbiota in this study. We used 3-month-old male senescence-accelerated prone mice (SAMP8). Read More

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October 2018
1 Read

Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing.

Biogerontology 2018 Dec 27;19(6):447-459. Epub 2018 Jul 27.

School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Moulsecoomb, Brighton, BN2 4GJ, UK.

Cellular senescence is now considered as a major mechanism in the development and progression of various diseases and this may include metabolic diseases such as obesity and type-2 diabetes. The presence of obesity and diabetes is a major risk factor in the development of additional health conditions, such as cardiovascular disease, kidney disease and cancer. Since senescent cells can drive disease development, obesity and diabetes can potentially create an environment that accelerates cell senescence within other tissues of the body. Read More

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December 2018
2 Reads
3.290 Impact Factor

Peroxisomes: role in cellular ageing and age related disorders.

Biogerontology 2018 10 2;19(5):303-324. Epub 2018 Jul 2.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India.

Peroxisomes are dynamic organelles essential for optimum functioning of a eukaryotic cell. Biogenesis of these organelles and the diverse functions performed by them have been extensively studied in the past decade. Their ability to perform functions depending on the cell type and growth conditions is unique and remarkable. Read More

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October 2018
11 Reads

Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence.

Biogerontology 2018 10 29;19(5):325-339. Epub 2018 Jun 29.

Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

The aging process is associated with a low-grade chronic inflammation and the accumulation of senescent cells into tissues. Diverse stresses can trigger cellular senescence, a cell fate characterized by cell-cycle arrest and flat morphology. Oncogenic signaling can also induce cellular senescence which has been termed oncogene-induced senescence (OIS). Read More

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October 2018
10 Reads

In memoriam Ladislas Robert (1924-2018).

Authors:
Tamas Fulop

Biogerontology 2018 Jul;19(3-4):185-187

Research Center on Aging, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada.

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July 2018
2 Reads

Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.

Biogerontology 2018 Dec 15;19(6):579-602. Epub 2018 Jun 15.

Progeria Research Team, Healthy Ageing Theme, Institute for Environment, Health and Societies, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, UB8 3PH, UK.

Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal premature ageing disease in children. HGPS is one of several progeroid syndromes caused by mutations in the LMNA gene encoding the nuclear structural proteins lamins A and C. In classic HGPS the mutation G608G leads to the formation of a toxic lamin A protein called progerin. Read More

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December 2018
8 Reads

Applying parametric models to survival data: tradeoffs between statistical significance, biological plausibility, and common sense.

Biogerontology 2018 10 4;19(5):341-365. Epub 2018 Jun 4.

N.N. Petrov Research Institute of Oncology, Pesochny-2, Saint-Petersburg, 197758, Russia.

Parametric models for survival data help to differentiate aging from other lifespan determinants. However, such inferences suffer from small sizes of experimental animal samples and variable animals handling by different labs. We analyzed control data from a single laboratory where interventions in murine lifespan were studied over decades. Read More

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October 2018
3 Reads

Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells.

Biogerontology 2018 07 26;19(3-4):287-301. Epub 2018 May 26.

Laboratory of bioengineering and regenerative medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave, Astana, Kazakhstan, Z05H0P9.

Mesenchymal stem cells (MSCs) represent a promising cell source for cellular therapy and tissue engineering and are currently being tested in a number of clinical trials for various diseases. However, like other somatic cells, MSCs age, and this senescence is accompanied by a progressive decline in stem cell function. Several lines of evidence suggest a role for the Rho family GTPase Cdc42 activity in cellular senescence processes. Read More

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July 2018
2 Reads

Mitigating peroxynitrite mediated mitochondrial dysfunction in aged rat brain by mitochondria-targeted antioxidant MitoQ.

Biogerontology 2018 07 17;19(3-4):271-286. Epub 2018 May 17.

Department of Zoology, University of Kalyani, Kalyani, West Bengal, 741235, India.

Although reactive oxygen species mediated oxidative stress is a well-documented mechanism of aging, recent evidences indicate involvement of nitrosative stress in the same. As mitochondrial dysfunction is considered as one of the primary features of aging, the present study was designed to understand the involvement of nitrosative stress by studying the impact of a mitochondria-targeted antioxidant MitoQ, a peroxynitrite (ONOO) scavenger, on mitochondrial functions. Four groups of rats were included in this study: Group I: Young-6 months (-MitoQ), Group II: Aged-22 months (- MitoQ), Group III: Young-6 months (+ MitoQ), Group IV: Aged-22 months (+ MitoQ). Read More

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July 2018
6 Reads
3.290 Impact Factor

Mechanics of population aging and survival.

Biogerontology 2018 07 10;19(3-4):251-269. Epub 2018 May 10.

Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, 23284-2030, USA.

In this paper we extend the previous work of Witten and her team on defining a classical physics-driven model of survival in aging populations (Eakin, Bull Math Biol 56(6):1121-1141, 1994; Eakin and Witten, Mech Aging Dev 78(2):85-101, 1995; Witten and Eakin, Exp Gerontol 32(2):259-285, 1997) by revisiting the concept of a force of aging and introducing the concepts of a momentum of aging, a kinetic energy and a potential energy of an aging population. We further extend the analysis beyond the deterministic Newtonian mechanics of a macroscopic population as a whole by considering the probabilistic nature of survival of individual population cohort members, thus producing new statistical physics-based concepts of entropy and of a gerontological "temperature". These new concepts are then illustrated with application to the classic parametric Gompertz survival model, which is a commonly used empirical descriptor for survival dynamics of mammalian species, human populations in particular. Read More

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July 2018
6 Reads

The impact of aging on CD4 T cell responses to influenza infection.

Biogerontology 2018 Dec 3;19(6):437-446. Epub 2018 Apr 3.

UConn Center on Aging and Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, 06030, USA.

CD4 T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4 T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearance and prolonged inflammation leading to increased pathology. Current research employing animal models and human subjects has provided new insights into the description and mechanisms of age-related CD4 T cell changes. Read More

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December 2018
5 Reads

Long-term exposure to TNF-α leads human skin fibroblasts to a p38 MAPK- and ROS-mediated premature senescence.

Biogerontology 2018 07 26;19(3-4):237-249. Epub 2018 Mar 26.

Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", 153 10, Athens, Greece.

Tumor necrosis factor α (TNF-α) is an inflammatory mediator overexpressed in the skin as a response to ultraviolet radiation, as well as in chronic non-healing wounds. On the other hand, senescent fibroblasts have been shown to accumulate in the skin under these stressful conditions. Accordingly, here we assessed the putative implication of TNF-α in the induction of premature senescence of human adult dermal fibroblasts. Read More

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July 2018
9 Reads

Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model system.

Authors:
Marina Ezcurra

Biogerontology 2018 Dec 19;19(6):567-578. Epub 2018 Mar 19.

Department of Genetics, Evolution and Environment and Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK.

High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complexity and heterogeneity of the human microbiome we need robust experimental models that allow the systematic manipulation of variables to test the multitude of hypotheses arisen from large-scale 'meta-omic' projects. Read More

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December 2018
5 Reads

A review of telomere length in sarcopenia and frailty.

Biogerontology 2018 07 16;19(3-4):209-221. Epub 2018 Mar 16.

Department of Geriatrics, Neurosciences and Orthopedics, A. Gemelli Foundation, Catholic University of the Sacred Heart, School of Medicine, L.go F. Vito 1, 00168, Rome, Italy.

Sarcopenia and frailty are associated with several important health-related adverse events, including disability, loss of independence, institutionalization and mortality. Sarcopenia can be considered a biological substrate of frailty, and the prevalence of both these conditions progressively increases with age. Telomeres are nucleoprotein structures located at the end of linear chromosomes and implicated in cellular ageing, shorten with age, and are associated with various age-related diseases. Read More

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July 2018
4 Reads

Involvement of the autophagic pathway in the progression of AMD-like retinopathy in senescence-accelerated OXYS rats.

Biogerontology 2018 07 28;19(3-4):223-235. Epub 2018 Feb 28.

Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia.

Age-related macular degeneration (AMD) is a complex neurodegenerative disease resulting in a loss of central vision in the elderly. It is currently assumed that impairment of autophagy may be one of the key mechanisms leading to AMD. Here we estimated the influence of age-related autophagy alterations in the retina on the development of AMD-like retinopathy in senescence-accelerated OXYS rats. Read More

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July 2018
4 Reads

Gene expression hallmarks of cellular ageing.

Biogerontology 2018 Dec 28;19(6):547-566. Epub 2018 Feb 28.

Epigenetics Programme, Babraham Institute, Cambridge, UK.

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven by highly conserved cell intrinsic processes, and a set of unifying hallmarks of ageing has been defined. Here, we survey reports of age-linked changes in basal gene expression across eukaryotes from yeast to human and identify six gene expression hallmarks of cellular ageing: downregulation of genes encoding mitochondrial proteins; downregulation of the protein synthesis machinery; dysregulation of immune system genes; reduced growth factor signalling; constitutive responses to stress and DNA damage; dysregulation of gene expression and mRNA processing. Read More

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December 2018
4 Reads

Mitochondria, its DNA and telomeres in ageing and human population.

Biogerontology 2018 07 28;19(3-4):189-208. Epub 2018 Feb 28.

Latvian Biomedical Research and Study Centre, Ratsupites Street 1, Riga, 1067, Latvia.

In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to slow down or even prevent these diseases and provide opportunities for healthy ageing; additionally, we all want to live longer. Read More

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July 2018
5 Reads

Polyphenols protect against age-associated apoptosis in female rat cochleae.

Biogerontology 2018 04 23;19(2):159-169. Epub 2018 Jan 23.

European University of Madrid, Calle del Tajo S/N, Villaviciosa de Odón, 28670, Madrid, Spain.

Dietary antioxidants, polyphenols, have been found to be beneficial in protecting against the generation of oxidative stress in various diseases associated with aging. Age-related hearing loss (AHL) is the number one neurodegenerative disorder on our aged population. Sprague-Dawley rats divided into five groups according to their age (3, 6, 12, 18 and 24 months old) and treated with 100 mg/day/kg body weight of polyphenols were used. Read More

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April 2018
4 Reads

Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers.

Biogerontology 2018 04 16;19(2):145-157. Epub 2018 Jan 16.

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332-0230, USA.

Pharmaceutical interventions can slow aging in animals, and have advantages because their dose can be tightly regulated and the timing of the intervention can be closely controlled. They also may complement environmental interventions like caloric restriction by acting additively. A fertile source for therapies slowing aging is FDA approved drugs whose safety has been investigated. Read More

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April 2018
18 Reads

Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging.

Biogerontology 2018 04 16;19(2):121-132. Epub 2018 Jan 16.

Department of Neurobiology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia.

Albeit aging is an inevitable process, the rate of aging is susceptible to modifications. Dietary restriction (DR) is a vigorous nongenetic and nonpharmacological intervention that is known to delay aging and increase healthspan in diverse species. This study aimed to compare the impact of different restricting feeding regimes such as limited daily feeding (LDF, 60% AL) and intermittent feeding (IF) on brain energy homeostasis during aging. Read More

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April 2018
5 Reads
3.290 Impact Factor

Repurposing existing drugs for new AMPK activators as a strategy to extend lifespan: a computer-aided drug discovery study.

Biogerontology 2018 04 15;19(2):133-143. Epub 2018 Jan 15.

Department of Biology, Faculty of Science, Golestan University, Gorgan, Iran.

Dietary restriction is one of the several ways which could putatively extend organisms' lifespan, ranging from Saccharomyces cerevisiae to rodents, by activating the AMP-activated protein kinase (AMPK), an ATP/AMP sensor. Extensive researches have shown that aging reduces sensibility of AMPK and eventually causes energy imbalance in cells. Research in mammals' AMPK depicts that this signaling molecule could control autophagy, improve cellular stress resistance and suppress inflammatory responses. Read More

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April 2018
4 Reads

Organ reserve, excess metabolic capacity, and aging.

Biogerontology 2018 04 15;19(2):171-184. Epub 2018 Jan 15.

School of Medicine, California University of Science and Medicine (CUSM), 217 E Club Center Dr. Suite A, San Bernardino, CA, 92408, USA.

"Organ reserve" refers to the ability of an organ to successfully return to its original physiological state following repeated episodes of stress. Clinical evidence shows that organ reserve correlates with the ability of older adults to cope with an added workload or stress, suggesting a role in the process of aging. Although organ reserve is well documented clinically, it is not clearly defined at the molecular level. Read More

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April 2018
10 Reads

A network-based meta-analysis for characterizing the genetic landscape of human aging.

Biogerontology 2018 02 21;19(1):81-94. Epub 2017 Dec 21.

Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Viale Druso 1, 39100, Bolzano, Italy.

Great amounts of omics data are generated in aging research, but their diverse and partly complementary nature requires integrative analysis approaches for investigating aging processes and connections to age-related diseases. To establish a broader picture of the genetic and epigenetic landscape of human aging we performed a large-scale meta-analysis of 6600 human genes by combining 35 datasets that cover aging hallmarks, longevity, changes in DNA methylation and gene expression, and different age-related diseases. To identify biological relationships between aging-associated genes we incorporated them into a protein interaction network and characterized their network neighborhoods. Read More

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February 2018
6 Reads

Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans.

Biogerontology 2018 04 18;19(2):109-120. Epub 2017 Dec 18.

Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR, Palacký University, Šlechtitelů 27, 78371, Olomouc, Czech Republic.

Cytokinins are phytohormones that are involved in many processes in plants, including growth, differentiation and leaf senescence. However, they also have various activities in animals. For example, kinetin and trans-zeatin can reduce levels of several aging markers in human fibroblasts. Read More

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April 2018
13 Reads

Cell wall biosynthesis impairment affects the budding lifespan of the Saccharomyces cerevisiae yeast.

Biogerontology 2018 02 30;19(1):67-79. Epub 2017 Nov 30.

Department of Plant Physiology, Institute of Biotechnology, University of Rzeszow, Rzeszow, Poland.

The Saccharomyces cerevisiae yeast is one of the most widely used model in studies of cellular and organismal biology, including as aging and proliferation. Although several constraints of aging and budding lifespan have been identified, these processes have not yet been fully understood. Previous studies of aging in yeast have focused mostly on the molecular basics of the underlying mechanisms, while physical aspects, particularly those related to the cell wall, were rather neglected. Read More

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February 2018
5 Reads

Echinacoside, a phenylethanoid glycoside from Cistanche deserticola, extends lifespan of Caenorhabditis elegans and protects from Aβ-induced toxicity.

Biogerontology 2018 02 28;19(1):47-65. Epub 2017 Nov 28.

Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.

Cistanche deserticola has been found to exert protection against aging and age-related diseases, but mechanisms underlying its longevity effects remain largely unclear. Here, the multicellular model organism Caenorhabditis elegans was employed to identify lifespan extending and protective effects against β-amyloid (Aβ) induced toxicity by echinacoside (ECH), a phenylethanoid glycoside isolated from C. deserticola. Read More

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February 2018
7 Reads