1,936 results match your criteria Biofactors[Journal]


Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number.

Biofactors 2020 Jun 1. Epub 2020 Jun 1.

Miller School of Medicine, University of Miami, Miami, Florida, USA.

Cell senescence is due to the permanent cell cycle arrest that occurs as a result of the inherent limited replicative capacity toward the Hayflick limit (replicative senescence), or in response to various stressors (stress-induced premature senescence, SIPS). With the acquisition of the senescence-associated secretory phenotype (SASP), cells release several molecules (cytokines, proteases, lipids), and express the senescence-associated beta-galactosidase (SA-β-Gal). Here we tested whether vitamin E affects SA-β-Gal in an in vitro model of cell ageing. Read More

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http://dx.doi.org/10.1002/biof.1636DOI Listing

Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma.

Biofactors 2020 May 24. Epub 2020 May 24.

Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, China.

Calycosin is a naturally occurring phytoestrogen, and it has the anti-nasopharyngeal carcinoma (NPC) action played by calycosin. However, the elaborate mechanisms of calycosin treating NPC remain to be unrevealed. In current report, a promising tool of network pharmacology method was used to uncover the anti-NPC targets and therapeutic mechanisms played by calycosin. Read More

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http://dx.doi.org/10.1002/biof.1639DOI Listing

The roles of melatonin on kidney injury in obese and diabetic conditions.

Biofactors 2020 May 24. Epub 2020 May 24.

Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney injury in obese and diabetic conditions. Read More

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http://dx.doi.org/10.1002/biof.1637DOI Listing

New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors.

Biofactors 2020 May 22. Epub 2020 May 22.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

As an evolutionarily conserved pathway, Hippo signaling pathway impacts different pathology and physiology processes such as wound healing, tissue repair/size and regeneration. When some components of Hippo signaling dysregulated, it affects cancer cells proliferation. Moreover, the relation Hippo pathway with other signaling including Wnt, TGFβ, Notch, and EGFR signaling leaves effect on the proliferation of cancer cells. Read More

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http://dx.doi.org/10.1002/biof.1634DOI Listing

Dicer and Drosha expression in patients with nephrotic syndrome.

Biofactors 2020 May 15. Epub 2020 May 15.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Podocytes play an essential role in the regulation of glomerular filtration and the appropriate function of the kidney. Podocytes injury is involved in the pathogenesis of nephrotic syndrome (NS), a common renal glomerulus dysfunction characterized by proteinuria. Some in vivo studies in Dicer/Drosha knockout mice indicate the importance of Dicer, Drosha, and microRNAs (miRNAs) in the pathogenesis of NS. Read More

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http://dx.doi.org/10.1002/biof.1638DOI Listing

High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E.

Biofactors 2020 May 8. Epub 2020 May 8.

Department of Biochemistry, Faculty of Medicine, Marmara University, Istanbul, Turkey.

Formation of atherosclerotic plaques, called atherogenesis, is a complex process affected by genetic and environmental factors. It was proposed that endoplasmic reticulum (ER) stress is an important factor in the pathogenesis of atherosclerosis and that vitamin E affects atherosclerotic plaque formation via its antioxidant properties. Here, we investigated ER stress-related molecular mechanisms in high-cholesterol diet (HCD, 2%)-induced atherosclerosis model and the role of vitamin E supplementation in it, beyond its antioxidant properties. Read More

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http://dx.doi.org/10.1002/biof.1635DOI Listing
May 2020
4.592 Impact Factor

A systematic review and meta-analysis of the effect of Vitamin D-fortified food on glycemic indices.

Biofactors 2020 Apr 29. Epub 2020 Apr 29.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Some reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta-analysis was to evaluate effects of Vitamin D fortification on indices of glycemic control. Six databases (PubMed/Medline, ISI Web of Knowledge, Cochrane Library, Science Direct, Scopus, and Google Scholar) were searched, for randomized controlled trials that were published up to September 2018 and that compared the effect of Vitamin D-fortified food versus regular diet in relation to glycemic control. Read More

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http://dx.doi.org/10.1002/biof.1632DOI Listing

COVID-19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin.

Biofactors 2020 Apr 27. Epub 2020 Apr 27.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1002/biof.1633DOI Listing

Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF-β1/α-SMA/Col I and III pathway.

Biofactors 2020 Mar 31. Epub 2020 Mar 31.

Respiratory Medicine, Xingtai People's Hospital, Xingtai City, China.

Lung fibrosis is a progressive fatal lung disorder with significantly high mortality rates. Bleomycin (BLM) is one of the most commonly used chemotherapeutic agents for the treatment of several carcinomas. The most severe adverse effect of BLM is lung toxicity; therefore, BLM has been repeatedly reported to be considered amongst the most widely used agents for the induction of experimental lung fibrosis. Read More

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http://dx.doi.org/10.1002/biof.1629DOI Listing

Challenges in redox biology.

Biofactors 2020 03 31;46(2):191-192. Epub 2020 Mar 31.

Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1002/biof.1630DOI Listing

Plasmatic lipocalin-2 levels in chronic low-grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency.

Biofactors 2020 Mar 20. Epub 2020 Mar 20.

UOC Endocrinologia e Diabetologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.

Lipocalin-2 (LCN2) is a secreted glycoprotein involved in several chronic inflammatory processes. Metabolic syndrome (MetS) and adult growth hormone deficiency (GHD) are known as chronic inflammatory conditions. The primary objective of this observational cross-sectional study was to compare LCN2 plasmatic levels in these clinical settings, whereas the secondary objective was to investigate any possible correlation between LCN2 and BMI and/or indexes of insulin sensitivity/resistance. Read More

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http://dx.doi.org/10.1002/biof.1628DOI Listing

Skullcapflavone I has a potent anti-pancreatic cancer activity by targeting miR-23a.

Biofactors 2020 Mar 6. Epub 2020 Mar 6.

Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Baicalein has been widely studied and showed a potent activity against pancreatic cancer in both in vivo and in vitro studies. Little is known regarding the effects of Skullcapflavone I (SFI), despite they have similar structures. So, this study was to explore the function of SFI on human pancreatic cancer. Read More

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http://dx.doi.org/10.1002/biof.1621DOI Listing

CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2.

Biofactors 2020 Feb 27. Epub 2020 Feb 27.

Department of Vascular Surgery, The second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

The aim of this study was to investigate the possible influences of circPRKCI abnormal expression on lipopolysaccharide (LPS)-induced HK2 cell injury and its mechanism. The circPRKCI level was identified in serum samples from patients with urosepsis and healthy subjects, as well as LPS-treated HK2 cells by qRT-PCR. Cell viability, apoptosis, expression of proteins associated with apoptosis, and expression of pro-inflammatory cytokines in LPS-treated HK2 cells were measured. Read More

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http://dx.doi.org/10.1002/biof.1620DOI Listing
February 2020
4.592 Impact Factor

Anti-invasive effect and pharmacological mechanism of genistein against colorectal cancer.

Biofactors 2020 Feb 20. Epub 2020 Feb 20.

Department of Radiation Oncology of the Clinical Cancer Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, People's Republic of China.

Colorectal cancer (CRC) refers to a deadly carcinoma following potent invasiveness and metastasis in advanced stage. Unfortunately, existing anti-CRC medicine is insufficient for chemotherapy in addition to adverse effects. Consequently, the candidate natural ingredient for treating CRC needs to be further developed. Read More

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http://dx.doi.org/10.1002/biof.1627DOI Listing
February 2020

Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway.

Biofactors 2020 Feb 20. Epub 2020 Feb 20.

The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Quercetin is a plant flavonoid and has antioxidative properties. In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L-thyroxin (LT4)-induced hyperthyroidism rats. LT4 was used to prepare the experimental hyperthyroidism model via the intraperitoneal injection. Read More

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http://dx.doi.org/10.1002/biof.1626DOI Listing
February 2020

LncRNA TTN-AS1 acts as sponge for miR-15b-5p to regulate FBXW7 expression in ovarian cancer.

Biofactors 2020 Feb 12. Epub 2020 Feb 12.

Department of Gynaecology and Obstetrics, China-Japan Union Hospital of Jilin University, Changchun, China.

Emerging evidence showed that long noncoding RNA (lncRNA) plays crucial roles in regulating various cancer biological behaviors. Titin-antisense RNA1 (TTN-AS1) has been reported to have crucial roles in cancers but its role in ovarian cancer remains unknown. The levels of TTN-AS1, microNRA-15b-5p (miR-15b-5p), and F-box and WD repeat domain containing 7 (FBXW7) in ovarian cancer cells were measured by quantitative reverse-transcription PCR. Read More

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http://dx.doi.org/10.1002/biof.1622DOI Listing
February 2020
4.592 Impact Factor

Circular RNA-0072309 has antitumor influences in Hep3B cell line by targeting microRNA-665.

Biofactors 2020 Feb 11. Epub 2020 Feb 11.

Department of Hepatobiliary Surgery, Hwa Mei Hospital, University of Chinese Academy of Science (Ningbo No.2 Hospital), Ningbo, Zhejiang, China.

Liver cancer is a malignant tumor that occurs in the liver and has a high mortality rate. We strived to detect the role and mechanism of circRNA-0072309 in liver cancer. Hep3B cell line was transfected with pc-circ and si-circ for viability, colony formation, apoptosis, migration, and invasion tests, which were individually performed by CCK-8, colony formation detection, flow cytometry assay, migration and invasion assays. Read More

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http://dx.doi.org/10.1002/biof.1618DOI Listing
February 2020

6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: From cancer initiation to metastasis and chemoresistance.

Biofactors 2020 Feb 10. Epub 2020 Feb 10.

School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, London, UK.

Reprogrammed metabolism is key biochemical characteristic of malignant cells, which represents one of the emerging hallmarks of cancer. Currently, there is rising contemplation on oxidative pentose phosphate pathway (PPP) enzymes as potential therapeutic hits due to their affiliation with tumor metabolism. 6-Phosphogluconate dehydrogenase (6PGD), third oxidative decarboxylase of PPP, has received a great deal of attention during recent years due to its critical role in tumorigenesis and redox homeostasis. Read More

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http://dx.doi.org/10.1002/biof.1624DOI Listing
February 2020
4.592 Impact Factor

Dysfunction of thioredoxin triggers inflammation through activation of autophagy in chicken cardiomyocytes.

Biofactors 2020 Feb 7. Epub 2020 Feb 7.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, People's Republic of China.

Thioredoxin (Txn) is a hydrogen carrier protein and exists widely in organism. Txn deficiency implicates cardiomyocytes injury has been proven. However, the exact mechanism remains unclear. Read More

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http://dx.doi.org/10.1002/biof.1625DOI Listing
February 2020
4.592 Impact Factor

MicroRNA-31 weakens cisplatin resistance of medulloblastoma cells via NF-κB and PI3K/AKT pathways.

Biofactors 2020 Feb 6. Epub 2020 Feb 6.

Department of Pediatrics, Jining No. 1 People's Hospital, Jining, China.

Background: Medulloblastoma (MB) is a malignant intracranial tumor. Cisplatin is a broad-spectrum antitumor drug. It is important to study the cisplatin resistance of MB cells for the treatment of MB. Read More

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http://dx.doi.org/10.1002/biof.1616DOI Listing
February 2020

Insulin-like growth factor-II and bioactive proteins containing a part of the E-domain of pro-insulin-like growth factor-II.

Authors:
Jaap van Doorn

Biofactors 2020 Feb 6. Epub 2020 Feb 6.

Department of Genetics, Section Metabolic Diagnostics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Insulin-like growth factor (IGF)-II is considered to function as an important fetal growth factor, which is structurally and functionally related to IGF-I and proinsulin. At least in vitro, IGF-II actions are mediated through the IGF-I receptor and to a lesser extent the insulin receptor. After birth, the function of IGF-II is less clear although in adults the serum level of IGF-II exceeds that of IGF-I several fold. Read More

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http://dx.doi.org/10.1002/biof.1623DOI Listing
February 2020

Beyond cholesterol metabolism: The pleiotropic effects of proprotein convertase subtilisin/kexin type 9 (PCSK9). Genetics, mutations, expression, and perspective for long-term inhibition.

Biofactors 2020 Jan 30. Epub 2020 Jan 30.

Division of Clinical Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", Caserta, Italy.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has a crucial role in lipid metabolism, particularly due to its function in low-density lipoprotein receptor degradation. Gain-of-function genetic mutations of PCSK9 result in autosomal dominant familial hypercholesterolemia, characterized by high levels of low-density lipoprotein cholesterol (LDL-C) and clinical signs of early atherosclerosis. In recent years, PCSK9 has become an important therapeutic target for cholesterol-lowering therapy. Read More

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http://dx.doi.org/10.1002/biof.1619DOI Listing
January 2020

Alkannin represses growth of pancreatic cancer cells based on the down regulation of miR-199a.

Biofactors 2020 Jan 22. Epub 2020 Jan 22.

Department of Critical Care Medicine, Jining No.1 People's Hospital, Jining, Shandong, China.

Alkannin displays tumor suppressive activity by initiating apoptosis. Here, we corroborated its role in pancreatic carcinoma (PANC-1) cells and addressed the molecular mechanism in which microRNA-199a (miR-199a) and Klotho might be implicated. PANC-1 and MIN6 cells were treated by alkannin and its role was evaluated in cellular viability. Read More

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http://dx.doi.org/10.1002/biof.1613DOI Listing
January 2020

Neuroprotective effects of isoquercitrin in diabetic neuropathy via Wnt/β-catenin signaling pathway inhibition.

Biofactors 2020 Jan 21. Epub 2020 Jan 21.

Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Punjab, India.

Diabetic neuropathy is a peripheral nervous system disorder affecting both somatic and autonomic components of nervous system. A growing body of evidence have depicted that high glucose levels can induce activation of the Wnt/β-catenin pathway, however there are no studies targeting this pathway in DN. The intent of the present study was to investigate the effects of isoquercitrin (ISQ), a Wnt/β-catenin signaling pathway inhibitor, in diabetic neuropathy. Read More

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http://dx.doi.org/10.1002/biof.1615DOI Listing
January 2020
4.592 Impact Factor

JMJD6-STAT3 axis promotes autophagy in osteosarcoma cancer cells by regulating ATG.

Biofactors 2020 Jan 20. Epub 2020 Jan 20.

Department of Children Rehabilitation, Jining No.1 People's Hospital, Jining, China.

Background: Osteosarcoma cancer is a malignant tumor with poor outcome. Activation of STAT3 is closely related with tumor development. We intended to study the effects of JMJD6 on phosphorylation of STAT3 at Y705 site. Read More

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http://dx.doi.org/10.1002/biof.1614DOI Listing
January 2020
4.592 Impact Factor

Protective role of poly(lactic-co-glycolic) acid nanoparticle loaded with resveratrol against isoproterenol-induced myocardial infarction.

Biofactors 2020 Jan 11. Epub 2020 Jan 11.

Department of Cardiology, Jinan Central Hospital Affiliated to Shandong University, Jinan City, Shandong Province, China.

Our study is aimed at evaluating the effects of pretreatment with Poly(lactic-co-glycolic) acid nanoparticle loaded with resveratrol (RSV PLGA NPs) compared to conventional resveratrol (RSV) on isoproterenol (ISO) induced myocardial infarction (MI) in rats. Sixty rats were randomly divided into six groups of 10 rats each. RSV and RSV PLGA NPs were given by gavage in two different doses (50 mg/kg body weight [BW] and 100 mg/kg BW) for 3 weeks. Read More

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http://dx.doi.org/10.1002/biof.1611DOI Listing
January 2020
4.592 Impact Factor

The role of KLF14 in multiple disease processes.

Biofactors 2020 Mar 11;46(2):276-282. Epub 2020 Jan 11.

Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Kruppel-like factor 14 (KLF14) is a newly identified member of the KLF family. Expression of KLF14 is induced by TGF-β in intrauterine and ectodermal tissue. Initial researches on KLF14 focused on its role in lipid and glucose metabolism. Read More

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http://dx.doi.org/10.1002/biof.1612DOI Listing

Propofol exerts neuroprotective functions by down-regulating microRNA-19a in glutamic acid-induced PC12 cells.

Biofactors 2020 Jan 8. Epub 2020 Jan 8.

Department of Anesthesiology, Huaihe Hospital of Henan University, Kaifeng, China.

Background: Propofol, a kind of intravenous sedative drug, is certified that exerts anti-inflammation and antitumor functions. However, the influence of propofol in cerebral injury and the corresponding mechanism remains unexplained, that our article focuses on.

Methods: PC12 cells were treated with propofol and exposed in glutamic acid (Glu) solutions. Read More

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http://dx.doi.org/10.1002/biof.1607DOI Listing
January 2020

Emodin relieved lipopolysaccharide-evoked inflammatory damage in WI-38 cells by up-regulating taurine up-regulated gene 1.

Biofactors 2020 Jan 7. Epub 2020 Jan 7.

Department of Pediatrics, Jining No.1 People's Hospital, Jining, Shandong, China.

Background: Neonatal pneumonia (NP) has a high fatality rate in neonatal illness. This research investigated the functions of emodin on lipopolysaccharide (LPS)-evoked inflammatory injury in WI-38 cells.

Methods: Cell counting kit-8 (CCK-8) assay and flow cytometry were utilized for examining the impacts of LPS and emodin on viability and apoptosis, respectively. Read More

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http://dx.doi.org/10.1002/biof.1609DOI Listing
January 2020

Effects of 1,25(OH) D on lipid droplet growth in adipocytes.

Biofactors 2020 Jan 6. Epub 2020 Jan 6.

Department of Nutrition and Food Hygiene, School of Public Health, Southwest Medical University, Luzhou, China.

This study aimed to explore the effects of 1,25(OH) D on lipid droplet (LD) growth in 3T3-L1 adipocytes of hypertrophy model. Cocktail method was used to induce differentiation in 3T3-L1 cells. After 8 days, the cells were modeled by 100, 300, 600, and 900 μM palmitic acid (PA) for 24 hr. Read More

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http://dx.doi.org/10.1002/biof.1610DOI Listing
January 2020
4.592 Impact Factor

The MORN domain of Junctophilin2 regulates functional interactions with small-conductance Ca -activated potassium channel subtype2 (SK2).

Biofactors 2020 Jan 6. Epub 2020 Jan 6.

Department of Physiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.

Small-conductance Ca -activated K channel subtype2 (SK2) are stable macromolecular complexes that regulate myocardial excitability and Ca homeostasis. Junctophilin-2 (JP2) is a membrane-binding protein, which provides functional crosstalk by physically linking with the cell-surface and intracellular ion channels. We previously demonstrated that the MORN domain of JP2 interacts with SK2 channels. Read More

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http://dx.doi.org/10.1002/biof.1608DOI Listing
January 2020

Central nesfatin-1 activates lipid mobilization in adipose tissue and fatty acid oxidation in muscle via the sympathetic nervous system.

Biofactors 2020 Jan 3. Epub 2020 Jan 3.

Special Medicine Department, Basic Medical College, Qingdao University, Qingdao, China.

Little is known about the influence of central nesfatin-1 on lipid metabolism under diabetic conditions. The main objective of this study was to characterize the mechanisms by which central nesfatin-1 regulates lipid metabolism in streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) and whether the sympathetic nervous system is involved. Male Kunming mice were fed high-fat diets (HFDs) and were treated twice with low-dose STZ (100 mg/kg, intraperitoneal [IP]) to generate the T2DM model. Read More

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http://dx.doi.org/10.1002/biof.1600DOI Listing
January 2020

Long noncoding RNA-GAS5 attenuates progression of glioma by eliminating microRNA-10b and Sirtuin 1 in U251 and A172 cells.

Biofactors 2019 Dec 30. Epub 2019 Dec 30.

Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Long noncoding RNA (lncRNA) growth arrest-specific 5 (GAS5) is implicated in several cancers via modulating microRNAs (miRs). However, little information is available about the correlation between GAS5 and miR-10b. Therefore, we sought out to investigate the biological role of GAS5-miR-10b node mainly in glioma cells. Read More

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http://dx.doi.org/10.1002/biof.1604DOI Listing
December 2019

Long noncoding RNA Mirt2 prohibits lipopolysaccharide-evoked HK-2 cell injury via modulation of microRNA-126.

Biofactors 2019 Dec 30. Epub 2019 Dec 30.

Heart Center, Qingdao Women and Children's Hospital, Qingdao, Shandong, China.

Long noncoding RNA myocardial infarction-associated transcript 2 (lncRNA Mirt2) is a burgeoning lncRNA, its anti-inflammatory capacity has been testified. Nonetheless, the functions of Mirt2 in immunoglobulin A nephropathy are unexplored. We tried to impart the influences of Mirt2 in lipopolysaccharide (LPS)-evoked HK-2 cells damage. Read More

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http://dx.doi.org/10.1002/biof.1602DOI Listing
December 2019

Gypenoside A protects ischemia/reperfusion injuries by suppressing miR-143-3p level via the activation of AMPK/Foxo1 pathway.

Biofactors 2019 Dec 30. Epub 2019 Dec 30.

Department of Endocrine Metabolic Diseases, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, China.

Ischemia-reperfusion (I/R) injury is a major side effect associated with coronary heart disease (CHD). Gypenoside A (GP) is one of the dominant active components of Gynostemma pentaphyllum and has the potential to attenuate myocardial I/R injuries. The major purpose of this study was to explore the mechanism driving the protective effect of GP on myocardial tissue by focusing on the interaction between GP and miR-143-3p. Read More

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http://dx.doi.org/10.1002/biof.1601DOI Listing
December 2019

Knockdown of circular RNA circZNF652 remits LPS-induced inflammatory damage by regulating miR-181a.

Biofactors 2019 Dec 30. Epub 2019 Dec 30.

Department of Family Planning Technial Service, Jining Maternal and Child Health Family Planning Service Center, Jining, Shandong, China.

Background: Infantile pneumonia (IP) is a usual disease in infants and young children. The function and underlying mechanism of circZNF652 on lipopolysaccharide (LPS)-triggered inflammatory damage in WI-38 cells were detected in this article.

Methods: WI-38 cells were induced by dosages of LPS to construct inflammatory injury model. Read More

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http://dx.doi.org/10.1002/biof.1606DOI Listing
December 2019

Resveratrol ameliorates rheumatoid arthritis via activation of SIRT1-Nrf2 signaling pathway.

Biofactors 2019 Dec 28. Epub 2019 Dec 28.

Department of Histology and Embryology, Anhui Medical University, Hefei, China.

The present study was designed to explore the biological role of resveratrol (RES) in rheumatoid arthritis (RA) and the underlying mechanism. The adjuvant-induced arthritic rats were administered RES on the 12th day after model establishment, and then arthritis assessment, oxidative stress measurement, histological examination, and immunohistochemical staining were performed. The primary rat fibroblast-like synoviocytes (FLS) were isolated and treated with RES in vitro and then cell proliferation and apoptosis assay were examined. Read More

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http://dx.doi.org/10.1002/biof.1599DOI Listing
December 2019

Quercetin: A promising phytochemical for the treatment of glioblastoma multiforme.

Biofactors 2019 Dec 27. Epub 2019 Dec 27.

Halal Research Center of IRI, FDA, Tehran, Iran.

Quercetin, a plant-derived flavonoid, is known for its antitumor and antiproliferative activities. Glioblastoma multiforme (GBM), as a highly aggressive cerebrum tumor, has a poor prognosis that is approximately 12 months despite standard therapy. Therefore, because of the low effectiveness of the current therapeutic strategies, additional medications in combination with chemotherapy and radiotherapy are needed, which could improve the prognosis of GBM patients. Read More

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http://dx.doi.org/10.1002/biof.1605DOI Listing
December 2019

Modulatory effects of curcumin on the atherogenic activities of inflammatory monocytes: Evidence from in vitro and animal models of human atherosclerosis.

Biofactors 2019 Dec 24. Epub 2019 Dec 24.

Halal Research Center of IRI, FDA, Tehran, Iran.

Atherosclerosis is a complex and long-lasting disorder characterized by chronic inflammation of arteries that leads to the initiation and progression of lipid-rich plaques, in which monocytes/macrophages play the central role in endothelial inflammation and taking up these lipids. Circulating monocytes can adopt a long-term proinflammatory phenotype leading to their atherogenic activities. During atherogenic condition, inflammatory monocytes adhere to the surface of the activated endothelial cells and then transmigrate across the endothelial monolayer into the intima, where they proliferate and differentiate into macrophages and take up the lipoproteins, forming foam cells that derive atherosclerosis progression. Read More

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http://dx.doi.org/10.1002/biof.1603DOI Listing
December 2019

Osteogenesis and bone remodeling: A focus on growth factors and bioactive peptides.

Biofactors 2019 Dec 19. Epub 2019 Dec 19.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical, Mashhad, Iran.

Bone is one of the most frequently transplanted tissues. The bone structure and its physiological function and stem cells biology were known to be closely related to each other for many years. Bone is considered a home to the well-known systems of postnatal mesenchymal stem cells (MSCs). Read More

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http://dx.doi.org/10.1002/biof.1598DOI Listing
December 2019

The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review.

Biofactors 2019 Dec 17. Epub 2019 Dec 17.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Microglia are the primary innate immune system cells in the central nervous system (CNS). They are crucial for the immunity, neurogenesis, synaptogenesis, neurotrophic support, phagocytosis of cellular debris, and maintaining the CNS integrity and homeostasis. Invasion by pathogens as well as in CNS injuries and damages results in activation of microglia known as microgliosis. Read More

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http://dx.doi.org/10.1002/biof.1597DOI Listing
December 2019
4.592 Impact Factor

Quercetin alleviates lipopolysaccharide-induced inflammatory responses by up-regulation miR-124 in human renal tubular epithelial cell line HK-2.

Biofactors 2019 Dec 5. Epub 2019 Dec 5.

Department of Nephrology, Linyi Central Hospital, Linyi, Shandong, China.

Chronic kidney disease (CKD) is a persistent kidney structural and functional disorder. Quercetin is one of active extracted flavonoids and has protective effects. Therefore, we proposed to survey the effect of Quercetin on CKD. Read More

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http://dx.doi.org/10.1002/biof.1596DOI Listing
December 2019

Protective impacts of circular RNA VMA21 on lipopolysaccharide-engendered WI-38 cells injury via mediating microRNA-142-3p.

Biofactors 2019 Dec 3. Epub 2019 Dec 3.

Department of Pediatrics, Jining No.1 People's Hospital, Jining, China.

CircRNA derived from vacuolar ATPase assembly factor (circVMA21) is a newly-researched circRNA, which is reported to adjust the degeneration of intervertebral disc. But, function of circVMA21 in infantile pneumonia is yet to be explored. The research surveyed the role of circVMA21 in lipopolysaccharide (LPS)-caused WI-38 cell inflammatory injury. Read More

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http://dx.doi.org/10.1002/biof.1593DOI Listing
December 2019

Circular RNA ANKRD36 attends to lipopolysaccharide-aroused MRC-5 cell injury via regulating microRNA-31-3p.

Biofactors 2019 Dec 2. Epub 2019 Dec 2.

Department of Pediatrics, Jining No.1 People's Hospital, Jining, Shandong, China.

Background: Some circular RNAs (circRNAs) are reported to attend to the pathogenesis of pneumonia. This study tested the impact of circRNA ankyrin repeat domain 36 (circANKRD36) on human embryonic lung fibroblast MRC-5 cell injury irritated by lipopolysaccharide (LPS).

Methods: After LPS irritation, viability, apoptosis, ROS, protein, and cytokines, along with circANKRD36 were tested by CCK-8, Annexin V-FITC, DCFH-DA, and ELISA or Western blot. Read More

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http://dx.doi.org/10.1002/biof.1592DOI Listing
December 2019

The inhibitory function of icariin in cell model of benign prostatic hyperplasia by upregulation of miR-7.

Biofactors 2019 Nov 29. Epub 2019 Nov 29.

Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, China.

In spite of a considerable breakthrough in antitumor effects of icariin (ICA), the studies regarding other functions of ICA still have not explored widely. This study aimed to report the function of ICA about the growth and migration of benign prostatic hyperplasia epithelial cell line (BPH-1) and human prostate epithelial cell line RWPE-1. Both BPH-1 and RWPE-1 cells were treated with ICA for 12 hr. Read More

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http://dx.doi.org/10.1002/biof.1591DOI Listing
November 2019

K-Ras -ERK1/2 pathway regulates H2BS14ph through Mst1 to facilitate the advancement of breast cancer cells.

Biofactors 2019 Nov 28. Epub 2019 Nov 28.

Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.

Breast cancer is a common cancer and becomes a severe healthy problem among females. Ras-ERK pathway and H2B phosphorylation at serine 14 (H2BS14ph) was involved in some cancers. Our research probed the feasible relationship between Ras-ERK1/2 and H2BS14ph in breast cancer cells and the underlying mechanism. Read More

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http://dx.doi.org/10.1002/biof.1589DOI Listing
November 2019

Angelica polysaccharide exhibits antitumor effect in neuroblastoma cell line SH-SY5Y by up-regulation of miR-205.

Biofactors 2019 Nov 23. Epub 2019 Nov 23.

Department of Pediatric Hematology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Neuroblastoma (NB) is a serious disease with high-risk and poor prognosis in children. Survivors often have serious side effects. Angelica polysaccharide (AP) has been proved to exert antitumor function. Read More

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http://dx.doi.org/10.1002/biof.1586DOI Listing
November 2019
4.592 Impact Factor

Thymoquinone attenuates oxidative stress of kidney mitochondria and exerts nephroprotective effects in oxonic acid-induced hyperuricemia rats.

Biofactors 2020 Mar 23;46(2):292-300. Epub 2019 Nov 23.

Department of Microbiology & Clinical Parasitology and Centre for Stem Cell Research, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Background: Recent studies indicate hyperuricemia as an aggravating factor for kidney diseases progression. Basic research for novel agents to reduce hyperuricemia and kidney abnormalities will be highly rewarding. Herein, we report Thymoquinone (Tq) as an active constituent of Nigella sativa to have renal protective effective against oxonic acid (OA)-induced hyperuricemia, hypertension, and renal oxidative stress in rat models. Read More

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http://dx.doi.org/10.1002/biof.1590DOI Listing

The role of Interleukin 1 receptor antagonist in mesenchymal stem cell-based tissue repair and regeneration.

Biofactors 2020 Mar 22;46(2):263-275. Epub 2019 Nov 22.

Faculty of Medical Sciences, Department for Microbiology and Immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, Kragujevac, Serbia.

Interleukin (IL)-1 receptor antagonist (IL-1Ra), a naturally occurring antagonist of IL-1α/IL-1β signaling pathways, has been attributed to the immunosuppressive effects of mesenchymal stem cells (MSCs). MSCs, in IL-1Ra-dependent manner, suppressed production of IL-1β in dermal macrophages, induced their polarization in anti-inflammatory M2 phenotype, attenuated antigen-presenting properties of dendritic cells (DCs), and promoted expansion of immunosuppressive T regulatory cells in the skin, which resulted in enhanced repair of the nonhealing wounds. Reduced activation of inflammasome and suppressed production of IL-1β in macrophages were mainly responsible for beneficial effects of MSC-derived IL-1Ra in alleviation of acute lung injury, dry eye syndrome, and corneal injury. Read More

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http://dx.doi.org/10.1002/biof.1587DOI Listing

Angelica polysaccharide alleviates TNF-α-induced MIN6 cell damage a through the up-regulation microRNA-143.

Biofactors 2019 Nov 20. Epub 2019 Nov 20.

Department of Traditional Chinese Medicine, Jining No.1 People's Hospital, Jining, China.

Diabetes, is the eighth cause of death worldwide, is a kind of metabolic disease. We planned to study the potentials of the angelica polysaccharide (AP) in MIN6 cell line. Cells were induced with tumor necrosis factor α (TNF-α) dilution or APsolutions, and transfected with microRNA-143 (miR-143) as well as the corresponding negative control (NC). Read More

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http://dx.doi.org/10.1002/biof.1588DOI Listing
November 2019