1,822 results match your criteria Biofactors[Journal]


Nodal increases the malignancy of childhood neuroblastoma cells via regulation of Zeb1.

Biofactors 2019 Apr 15. Epub 2019 Apr 15.

Department of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou City, Guangdong Province, China.

Neuroblastoma (NB) is one of the most common malignant tumors derived from pluripotent cells of the neural crest. Nodal is an important embryonic morphogen which can re-express in cancer cells. The roles of Nodal in the progression of NB are not illustrated. Read More

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http://dx.doi.org/10.1002/biof.1505DOI Listing
April 2019
1 Read

Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one-carbon cycle in Wistar rats.

Biofactors 2019 Apr 15. Epub 2019 Apr 15.

Department of Nutritional Medicine, Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth, Pune Satara Road, Pune, 411043, Maharashtra, India.

This study aims to test the hypothesis that vitamin D deficiency can influence long-chain polyunsaturated fatty acid metabolism through alterations in the one-carbon cycle. Wistar rats (n = 8 per group) were given either a control (1,000 IU D3/kg diet) or a vitamin D deficient (VDD) (0 IU D3/kg diet) diet from pre-pregnancy to delivery. On day 20 of gestation, pregnant female rats were delivered by C-section to collect placenta and blood. Read More

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http://dx.doi.org/10.1002/biof.1510DOI Listing

Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p-coumaric acid is a pivotal bioactive compound to this action.

Biofactors 2019 Apr 11. Epub 2019 Apr 11.

Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, South Carolina, Brazil.

Baccharis dracunculifolia is a medicinal plant native to southeastern Brazil and is the main botanical source used by bees (Apis mellifera) in the manufacture of green propolis and display similar gastroprotective action and chemical profile. This article reports the healing gastric ulcer activity of the hydroethanolic extract of B. dracunculifolia (HEBD) in an acetic acid-induced ulcer model. Read More

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http://dx.doi.org/10.1002/biof.1503DOI Listing

Reversing ROS-mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2-ARE signaling pathway.

Biofactors 2019 Apr 5. Epub 2019 Apr 5.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.

Chlorogenic acid (CA), the ester of caffeic acid and quinic acid, is one of the most abundant polyphenols in coffee, and has multiple pharmacological functions. The present study is designed to explore the protection provided by CA against hydrogen peroxide (H O )-induced oxidative damages in the rat pheochromocytoma cells, and the underlying mechanisms engaged in this process. CA displays robust free radical-scavenging activity in vitro. Read More

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http://dx.doi.org/10.1002/biof.1507DOI Listing
April 2019
2 Reads

Environmental noise induces the release of stress hormones and inflammatory signaling molecules leading to oxidative stress and vascular dysfunction-Signatures of the internal exposome.

Biofactors 2019 Apr 2. Epub 2019 Apr 2.

Department of Cardiology 1, Center for Cardiology, Mainz, Germany.

Environmental noise is a well-recognized health risk and part of the external exposome-the World Health Organization estimates that 1 million healthy life years are lost annually in Western Europe alone due to noise-related complications, including increased incidence of hypertension, heart failure, myocardial infarction, and stroke. Previous data suggest that noise works through two paired pathways in a proposed reaction model for noise exposure. As a nonspecific stressor, chronic low-level noise exposure can cause a disruption of sleep and communication leading to annoyance and subsequent sympathetic and endocrine stress responses leading to increased blood pressure, heart rate, stress hormone levels, and in particular more oxidative stress, being responsible for vascular dysfunction and representing changes of the internal exposome. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/biof.1506
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http://dx.doi.org/10.1002/biof.1506DOI Listing
April 2019
5 Reads

Cardioprotective effects of omega-3 fatty acids and ascorbic acid improve regenerative capacity of embryonic stem cell-derived cardiac lineage cells.

Biofactors 2019 Mar 25. Epub 2019 Mar 25.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

One of the major issues in cell therapy of myocardial infarction (MI) is early death of engrafted cells in a harsh oxidative stress environment, which limits the potential therapeutic utility of this strategy in the clinical setting. Increasing evidence implicates beneficial effects of omega-3 fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and ascorbic acid (AA) in cardiovascular diseases, in particular their role in ameliorating fibrosis. In the current study, we aim to assess the cytoprotective role of EPA + DHA and AA in protecting embryonic stem cell (ESC)-derived cardiac lineage cells and amelioration of fibrosis. Read More

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http://dx.doi.org/10.1002/biof.1501DOI Listing
March 2019
2 Reads
4.592 Impact Factor

miR-155-5p and miR-760 mediate radiation therapy suppressed malignancy of non-small cell lung cancer cells.

Biofactors 2019 Mar 22. Epub 2019 Mar 22.

Department of Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.

MicroRNAs (miRNAs) play important roles in tumorigenesis of various cancers. Recent study suggested that miRNAs are involved in the therapeutic functions of radiation during cancer treatment. We found that radiation can decrease the migration and invasion of non-small cell lung cancer (NSCLC) cells. Read More

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http://dx.doi.org/10.1002/biof.1500DOI Listing
March 2019
1 Read

Embelin attenuates cisplatin-induced nephrotoxicity: Involving inhibition of oxidative stress and inflammation in addition with activation of Nrf-2/Ho-1 pathway.

Biofactors 2019 Mar 20. Epub 2019 Mar 20.

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.

In kidneys, elevated levels of inflammatory cytokines and oxidative stress were observed in nephrotoxicity triggered by cisplatin. Embelin has the anti-inflammatory property. It also got anti-tumorigenic and antioxidant properties. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/biof.1502
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http://dx.doi.org/10.1002/biof.1502DOI Listing
March 2019
17 Reads

The inhibition of hypoxia-induced angiogenesis and metastasis by cinnamaldehyde is mediated by decreasing HIF-1α protein synthesis via PI3K/Akt pathway.

Biofactors 2019 Mar 10. Epub 2019 Mar 10.

Department of Zoology, West Bengal State University, Kolkata, West Bengal, India.

Tumor hypoxia is positively correlated with tumor aggressiveness and hence is a negative prognostic factor in cancer. As normal cells usually do not experience such low oxygen levels, hypoxic cell signaling has attracted significant attention for the development of tumor-selective treatment strategies. In response to hypoxia, the master transcriptional regulator, HIF-1α plays central role in cellular adaptation by transactivating several crucial downstream target genes, which are involved in angiogenesis, metastasis, and EMT. Read More

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http://dx.doi.org/10.1002/biof.1499DOI Listing

ROR1 associates unfavorable prognosis and promotes lymphoma growth in DLBCL by affecting PI3K/Akt/mTOR signaling pathway.

Biofactors 2019 Feb 24. Epub 2019 Feb 24.

Department of Hematology and Oncology, Department of Geriatric Lung Cancer Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province Geriatric Hospital, Nanjing, China.

The receptor-tyrosine-kinase (RTK)-like orphan receptor 1 (ROR1) is a transmembrane glycoprotein regarded as a tumor-associated antigen. ROR1 plays an important role in cancer development, but the detailed function of ROR1 in diffuse large B-cell lymphoma (DLBCL) remains unclear. In this study, we first detected ROR1 expression and evaluated the relationship between ROR1 expression and the clinicopathological characteristics of DLBCL patients. Read More

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http://dx.doi.org/10.1002/biof.1498DOI Listing
February 2019
5 Reads

Physiological impact of extracellular vesicles on female reproductive system; highlights to possible restorative effects on female age-related fertility.

Biofactors 2019 Feb 20. Epub 2019 Feb 20.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

An alternative mechanism of cell-to-cell communication via extracellular vesicles (EVs) has recently raised increasing attention. EVs are spherical structures comprising exosomes and microvesicles, capable of transferring regulatory molecules and genetic information from one cell to another. EVs act as modulators which can alter a wide spectrum of functions at the cellular level in the recipient cells, taking part in a variety of biological processes in both physiological and pathological conditions. Read More

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http://dx.doi.org/10.1002/biof.1497DOI Listing
February 2019
4.592 Impact Factor

Gut microbiota signatures and lipids metabolism profiles by exposure to polyene phosphatidylcholine.

Biofactors 2019 Feb 14. Epub 2019 Feb 14.

Department of Food Science & Nutrition, Zhejiang University, Hangzhou, China.

The aim of the study was to address the causality links and identify specific features of the gut microbiota signatures contributing to host lipids metabolism in the presence or absence of polyene phosphatidylcholine (PPC) administration, and evaluate potential risk of PPC consumption. About 20 C57BL/6J mice were randomly allocated into two groups, normal diet group (CK) and PPC administration group (205.2 mg/kg). Read More

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http://doi.wiley.com/10.1002/biof.1495
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http://dx.doi.org/10.1002/biof.1495DOI Listing
February 2019
11 Reads

High dose vitamin D supplementation is associated with an improvement in serum markers of liver function.

Biofactors 2019 Feb 13. Epub 2019 Feb 13.

Metabolic syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Limited studies have examined the effects of vitamin D on liver enzymes in patients with liver disease but none has explored its effects in the healthy subjects. The aim of present study was to evaluate the effects of a high dose vitamin D supplementation on measures of liver function. A total of 988 adolescent girls were recruited; all were assessed for liver function tests (LFTs) including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (ϒGT), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, and total protein before and after supplementation with 50,000 IU cholecalciferol perls. Read More

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http://dx.doi.org/10.1002/biof.1496DOI Listing
February 2019

Attenuated levels of ghrelin in synovial fluid is related to the disease severity of ankle post-traumatic osteoarthritis.

Biofactors 2019 Jan 30. Epub 2019 Jan 30.

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.

Post-traumatic osteoarthritis (PTOA) of ankle joints results in pain and reduced joint function. Ghrelin, a 28-amino-acid polypeptide, has been previously identified as the first cognate natural ligand that binds to the growth hormone secretagogue receptor. In the present study, ghrelin has been validated to exert cartilage-protective and anti-inflammatory effects. Read More

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http://dx.doi.org/10.1002/biof.1490DOI Listing
January 2019
1 Read

Association between platelet distribution width and serum uric acid in Chinese population.

Biofactors 2019 Jan 30. Epub 2019 Jan 30.

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW and hyperuricemia in a large Chinese cohort. Read More

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http://dx.doi.org/10.1002/biof.1491DOI Listing
January 2019
2 Reads
4.592 Impact Factor

Effects of antibiotics on degradation and bioavailability of different vitamin E forms in mice.

Biofactors 2019 Jan 29. Epub 2019 Jan 29.

Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

Tocopherols (T) and tocotrienols (T3), all existing in α, β, γ, and δ-forms, are the eight forms of vitamin E (VE). In this study, we investigated the effects of gut microbiota on the degradation and tissue levels of different VE forms by treating mice with antibiotics in drinking water for 12 days. The mice also received an intragastric (i. Read More

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http://dx.doi.org/10.1002/biof.1492DOI Listing
January 2019
1 Read

Human T lymphotropic virus type 1 and risk of cardiovascular disease: High-density lipoprotein dysfunction versus serum HDL-C concentrations.

Biofactors 2019 Jan 29. Epub 2019 Jan 29.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

High-density lipoprotein (HDL) is thought to be protective against cardiovascular disease (CVD), and HDL dysfunction is considered to be a risk factor for CVD. It is unclear whether there is an association between Human T lymphotropic virus type 1 (HTLV1) infection and CVD risk. We have assessed HDL lipid peroxidation (HDLox) as a marker of HDL dysfunction and CVD risk in a subgroup of the MASHAD cohort study. Read More

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http://dx.doi.org/10.1002/biof.1489DOI Listing
January 2019
2 Reads

Neuroprotection of mangiferin against oxidative damage via arousing Nrf2 signaling pathway in PC12 cells.

Biofactors 2019 Jan 11. Epub 2019 Jan 11.

State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, China.

Accumulating evidence demonstrates that oxidative stress is involved in the pathogenesis and progression of neurodegeneration. As NF-E2-related factor 2 (Nrf2) plays a crucial role in maintaining cellular redox homeostasis, small molecules with the ability in activation of Nrf2 pathway are promising neuroprotective agents. Mangiferin (Mg) is a xanthone glucoside extracted from mangoes and papayas, and has been reported to possess multiple pharmacological activities. Read More

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http://doi.wiley.com/10.1002/biof.1488
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http://dx.doi.org/10.1002/biof.1488DOI Listing
January 2019
11 Reads

Aspirin suppresses NFκB1 expression and inactivates cAMP signaling pathway to treat atherosclerosis.

Biofactors 2019 Jan 11. Epub 2019 Jan 11.

Department of Cardiology, the First Hospital of Jilin University, Changchun, Jilin, China.

Aspirin showed both favorable efficacy and safety in the treatment of atherosclerosis (AS). This study aimed to explore the effects of Aspirin on AS treatment. Differentially expressed mRNAs in AS were screened out and visualized by R project. Read More

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http://doi.wiley.com/10.1002/biof.1487
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http://dx.doi.org/10.1002/biof.1487DOI Listing
January 2019
6 Reads

Knockdown of LncRNA GHET1 suppresses prostate cancer cell proliferation by inhibiting HIF-1α/Notch-1 signaling pathway via KLF2.

Biofactors 2019 Jan 4. Epub 2019 Jan 4.

Department of Reproduction and Genetics, Maternity and Child Health Care Hospital, Tangshan, China.

Prostate cancer (PC) is one of the most common cancers in male groups worldwide. Long noncoding RNAs (LncRNAs) are reported to be dysregulated in a variety of cancers, including PC. This study aimed to explore the role of LncRNA GHET1 in the pathogenesis of PC. Read More

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http://dx.doi.org/10.1002/biof.1486DOI Listing
January 2019
2 Reads

Docosahexaenoic acid-thyroid hormone combined protocol as a novel approach to metabolic stress disorders: Relation to mitochondrial adaptation via liver PGC-1α and sirtuin1 activation.

Biofactors 2019 Mar 21;45(2):271-278. Epub 2018 Dec 21.

Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.

Docosahexaenoic acid (DHA) and 3,3',5-triiodothyronine (T ) combined protocol affords protection against liver injury via AMPK signaling supporting energy requirements. The aim of this work was to test the hypothesis that a DHA + T accomplish mitochondrial adaptation through downstream upregulation of PPAR-γ coactivator 1α (PGC-1α). Male Sprague-Dawley rats were given daily oral doses of 300 mg DHA/kg or saline (controls) for three consecutive days, followed by 0. Read More

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http://doi.wiley.com/10.1002/biof.1483
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http://dx.doi.org/10.1002/biof.1483DOI Listing
March 2019
8 Reads

Effect of biotin supplementation on fatty acid metabolic pathways in 3T3-L1 adipocytes.

Biofactors 2019 Mar 21;45(2):259-270. Epub 2018 Dec 21.

Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Instituto Nacional de Pediatria, Unidad de Genética de la Nutrición, Ciudad de México, Mexico.

Several studies have shown that pharmacological concentrations of biotin decrease serum lipid concentrations and the expression of lipogenic genes. Previous studies on epididymal adipose tissue in mice revealed that 8 weeks of dietary biotin supplementation increased the protein abundance of the active form of AMPK and the inactive forms acetyl CoA carboxylase (ACC)-1 and - 2, and decreased serum free fatty acid concentrations but did not affect lipolysis. These data suggest that pharmacological concentrations of the vitamin might affect fatty acid metabolism. Read More

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http://dx.doi.org/10.1002/biof.1480DOI Listing

Serological profile of asymptomatic HCV positive patients with low level of cryoglobulins.

Biofactors 2018 Dec 18. Epub 2018 Dec 18.

Dipartimento di Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.

Clinical spectrum of hepatitis C virus (HCV)-related cryoglobulinemia varies from an asymptomatic presentation to severe vasculitis and lymphoma. A recent study in HCV-negative patients suggests that low cryoglobulins (CGs) levels are responsible for severe renal and neurological complications. The aim of this study was to identify a panel of serological biomarkers associated with low levels of CGs in HCV-positive patients. Read More

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http://doi.wiley.com/10.1002/biof.1485
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http://dx.doi.org/10.1002/biof.1485DOI Listing
December 2018
12 Reads

Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways.

Biofactors 2019 Mar 18;45(2):152-168. Epub 2018 Dec 18.

Department of Clinical Sciences, Section of Biochemistry, Biology and Physics, Università Politecnica delle Marche, Ancona, Italy.

Glutathione is considered the major non-protein low molecular weight modulator of redox processes and the most important thiol reducing agent of the cell. The biosynthesis of glutathione occurs in the cytosol from its constituent amino acids, but this tripeptide is also present in the most important cellular districts, such as mitochondria, nucleus, and endoplasmic reticulum, thus playing a central role in several metabolic pathways and cytoprotection mechanisms. Indeed, glutathione is involved in the modulation of various cellular processes and, not by chance, it is a ubiquitous determinant for redox signaling, xenobiotic detoxification, and regulation of cell cycle and death programs. Read More

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http://doi.wiley.com/10.1002/biof.1476
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http://dx.doi.org/10.1002/biof.1476DOI Listing
March 2019
1 Read

Mid-region parathyroid hormone-related protein is a genome-wide chromatin-binding factor that promotes growth and differentiation of HB2 epithelial cells from the human breast.

Biofactors 2019 Mar 18;45(2):279-288. Epub 2018 Dec 18.

Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università di Palermo, Palermo, Italy.

Human parathyroid hormone-related protein (PTHrP) is a polyhormone that undergoes proteolytic cleavage producing smaller peptides which exert diversified biological effects. PTHrP signalization is prominently involved in breast development and physiology, but the studies have been focused onto either N-terminal species or full-length protein introduced by gene transfer techniques. Our present work investigates for the first time the effect of the mid-region PTHrP secretory form, that is, the fragment [38-94], on HB2 non-tumoral breast epithelial cells. Read More

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http://dx.doi.org/10.1002/biof.1484DOI Listing
March 2019
1 Read

Oxidative stress and inflammation, two features associated with a high percentage body fat, and that may lead to diabetes mellitus and metabolic syndrome.

Biofactors 2019 Jan 18;45(1):35-42. Epub 2018 Dec 18.

Metabolic Syndrome research center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Obesity is an important feature of the metabolic syndrome and is associated with an increased risk of type 2 diabetes mellitus, cardiovascular disease, and some cancers. The aim of this study was to determine the relationship between body fat percentage and an imbalance of the prooxidant/antioxidant balance (PAB), serum superoxide dismutase (SOD1) and inflammation (serum hs-CRP) and increase risk of metabolic syndrome and diabetes mellitus. In this study, 9154 individuals were recruited as part of the Mashhad Stroke and Heart Association Disorder (MASHAD) study. Read More

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http://dx.doi.org/10.1002/biof.1459DOI Listing
January 2019
2 Reads
4.592 Impact Factor

Functional capabilities of probiotic strains on attenuation of intestinal epithelial cell inflammatory response induced by TLR4 stimuli.

Biofactors 2019 Mar 11;45(2):223-235. Epub 2018 Dec 11.

Department of Rehabilitation Medicine of Korean Medicine, Dongguk University Ilsan Hospital, Goyang, Gyeonggi, Republic of Korea.

Intestinal epithelial cells (IECs) respond to intruders and their cellular molecules by displaying inflammatory state that can be abrogated by probiotics. However, the molecular mechanisms underlying the beneficial activity of probiotic strains have yet to be elucidated. This study was conducted to investigate whether probiotic strains have immunoregulatory effects in IECs, and how they respond to bacterial lipopolysaccharide (LPS) in vitro. Read More

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http://dx.doi.org/10.1002/biof.1475DOI Listing
March 2019
1 Read

Bioinformatic analysis of the prognostic value of the lncRNAs encoding snoRNAs in hepatocellular carcinoma.

Biofactors 2019 Mar 8;45(2):244-252. Epub 2018 Dec 8.

Department of Oncology Radiotherapy, Henan Provincial People's Hospital, Zhengzhou, Henan, China.

Some lncRNAs can encode small nucleolar RNAs (snoRNAs), called small nucleolar RNA host genes (SNHGs), which exert diverse regulatory effects on cellular processes. In this study, using RNA-seq and survival data in the Cancer Genome Atlas (TCGA)-Liver Hepatocellular Carcinoma (LIHC), we examined the expression profile of some SNHG genes and explored their prognostic value in hepatocellular carcinoma (HCC). Level-3 RNA-sequencing data, the clinicopathological and survival data of patients with primary HCC were downloaded from the UCSC Xena browser (https://xenabrowser. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/biof.1478
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http://dx.doi.org/10.1002/biof.1478DOI Listing
March 2019
21 Reads
4.592 Impact Factor

Structural analysis of the inhibitory effects of polyphenols, (+)-hopeaphenol and (-)-isohopeaphenol, on human SIRT1.

Biofactors 2019 Mar 11;45(2):253-258. Epub 2018 Dec 11.

Laboratory of Analytical Neurobiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, Japan.

Human sirtuin 1 (hSIRT1) is a NAD -dependent deacetylase that regulates several cellular processes. Unlike resveratrol, natural polymeric phenolic compounds isolated from Vitaceae are mostly hSIRT1 inhibitors. The resveratrol tetramer, (+)-hopeaphenol ((+)-HP), and its geometric isomer, (-)-isohopeaphenol ((-)-iHP), were tested for inhibitory effects on purified hSIRT1 using a fluorescent derivative of peptide substrate p53-AMC (Fluor de Lys) and a cofactor NAD . Read More

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http://dx.doi.org/10.1002/biof.1479DOI Listing
March 2019
2 Reads

Curcumin in tissue engineering: A traditional remedy for modern medicine.

Biofactors 2019 Mar 8;45(2):135-151. Epub 2018 Dec 8.

Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran.

Curcumin is the principal polyphenolic compound present in turmeric with broad applications in tissue engineering and regenerative medicine. It has some important inherent properties with the potential to facilitate tissue healing, including anti-inflammatory, anti-oxidant, and antibacterial activities. Therefore, curcumin has been used for the treatment of various damaged tissues, especially wound injuries. Read More

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http://dx.doi.org/10.1002/biof.1474DOI Listing
March 2019
2 Reads
4.592 Impact Factor

microRNA-96 protects pancreatic β-cell function by targeting PAK1 in gestational diabetes mellitus.

Biofactors 2018 Nov 8;44(6):539-547. Epub 2018 Dec 8.

Department of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Gestational diabetes mellitus (GDM) is a disease condition in which a woman develops high blood sugar levels during pregnancy, which might be induced by multiple factors. Among those relative factors, microRNA (miRNA) is well-known to be involved in GDM development. In this study, we investigated the role of miRNA in GDM by analyzing miRNA expression profiling in placenta tissues from healthy or GDM pregnancies. Read More

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http://dx.doi.org/10.1002/biof.1461DOI Listing
November 2018
1 Read
4.592 Impact Factor

Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.

Biofactors 2019 Jan 6;45(1):49-61. Epub 2018 Dec 6.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.

Glycosaminoglycans (GAGs) are linear, highly negatively charged carbohydrate chains present in connective tissues. Chondroitin sulfate (CS) and heparin (Hep) are also found in the numerous secretory granules of mast cells (MC), tissue immune cells involved in allergic and inflammatory reactions. CS and Hep may inhibit secretion of histamine from rat connective tissue MC, but their effect on human MC remains unknown. Read More

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http://dx.doi.org/10.1002/biof.1464DOI Listing
January 2019
4 Reads

Effect of high fat diet on NF-кB microRNA146a negative feedback loop in ovalbumin-sensitized rats.

Biofactors 2019 Jan 6;45(1):75-84. Epub 2018 Dec 6.

Lung Inflammatory Diseases Research Center, Department of Physiology, Ardabil University of Medical Sciences, Ardabil, Iran.

The present study aimed to investigate the role of microRNA-146a and its adapter proteins [interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)] in the pathogenesis of ovalbumin (OVA)-sensitized rats in association with the diet-induced obesity condition. Twenty male Wistar rats were divided into four groups: control with normal diet (ND), OVA-sensitized with normal diet (S + ND), high-fat diet (HFD), and OVA-sensitized with high-fat diet (S + HFD). All the animals were fed for 8 weeks with standard pelts or high-fat diet, and were then sensitized and challenged with OVA or saline for another 4 weeks. Read More

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http://doi.wiley.com/10.1002/biof.1466
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http://dx.doi.org/10.1002/biof.1466DOI Listing
January 2019
10 Reads

Docosahexaenoic acid promotes cell cycle arrest and decreases proliferation through WNT/β-catenin modulation in colorectal cancer cells exposed to γ-radiation.

Biofactors 2019 Jan 6;45(1):24-34. Epub 2018 Dec 6.

Cellular and Molecular Oncobiology Program, Brazilian National Cancer Institute, Rio de Janeiro, RJ, Brazil.

The effects of radiation are known to be potentiated by N-3 polyunsaturated fatty acids, which modulate several signaling pathways, but the molecular mechanisms through which these fatty acids enhance the anticancer effects of irradiation in colorectal cancer (CRC) treatment remain poorly elucidated. Here, we aimed to ascertain whether the fatty acid docosahexaenoic acid (DHA) exerts a modulating effect on the response elicited by radiation treatment (RT). Two CRC cell lines, Caco-2 and HT-29, were exposed to RT, DHA, or both (DHA + RT) for various times, and then cell viability, proliferation, and clonogenicity were assessed. Read More

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http://dx.doi.org/10.1002/biof.1455DOI Listing
January 2019
4 Reads

Microsomal pre-receptor cortisol production is inhibited by resveratrol and epigallocatechin gallate through different mechanisms.

Biofactors 2019 Mar 29;45(2):236-243. Epub 2018 Nov 29.

Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary.

Local activation of cortisol in hormone target tissues is a major determinant of glucocorticoid effect. Disorders in this peripheral cortisol metabolism play an important role in the development of metabolic diseases, such as obesity or type 2 diabetes mellitus. Hence, dietary factors influencing the activity of the involved enzymes can have major impacts on the risk of the above diseases. Read More

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http://dx.doi.org/10.1002/biof.1477DOI Listing
March 2019
3 Reads

Autoantibodies in HIV-infected patients: Cross site-specific hydrolysis of H1 histone and myelin basic protein.

Biofactors 2019 Mar 29;45(2):211-222. Epub 2018 Nov 29.

Siberian Division of Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.

Histones act as damage-associated molecules, while anti-DNA antibodies are directed against histone-DNA nucleosomal complexes. Myelin basic protein (MBP) plays an important role in the pathogenesis of multiple sclerosis. Autoantibodies (Abs) with enzymatic activities are the distinctive feature of some autoimmune and viral diseases. Read More

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http://doi.wiley.com/10.1002/biof.1473
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http://dx.doi.org/10.1002/biof.1473DOI Listing
March 2019
9 Reads

Early detection of cervical cancer based on high-risk HPV DNA-based genosensors: A systematic review.

Biofactors 2019 Mar 29;45(2):101-117. Epub 2018 Nov 29.

Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Human papillomavirus type (HPV) is a common cause of sexually transmitted disease (STD) in humans. HPV types 16 and 18 as the highest risk types are related with gynecologic malignancy and cervical cancer (CC) among women worldwide. Recently, considerable development of genosensors, which allows dynamic monitoring of hybridization events for HPV-16 and 18, has been a topic of focus by many researchers. Read More

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http://dx.doi.org/10.1002/biof.1465DOI Listing
March 2019
5 Reads

Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model.

Biofactors 2019 Jan 29;45(1):69-74. Epub 2018 Nov 29.

Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, Turkey.

Resveratrol, a phytochemical, acts several cellular signaling pathways and has anti-inflammatory potentials. The purpose of this study is to research the therapeutic effect of resveratrol in collagen-induced arthritis (CIA) model in rats and whether resveratrol affects the activities of signaling pathways those are potent pathogenic actors of rheumatoid arthritis. Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund's adjuvant in Wistar albino rats. Read More

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http://doi.wiley.com/10.1002/biof.1463
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http://dx.doi.org/10.1002/biof.1463DOI Listing
January 2019
15 Reads

Rhein reverses doxorubicin resistance in SMMC-7721 liver cancer cells by inhibiting energy metabolism and inducing mitochondrial permeability transition pore opening.

Biofactors 2019 Jan 29;45(1):85-96. Epub 2018 Nov 29.

Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Rhein, a monomeric anthraquinone obtained from the plant herb species Polygonum multiflorum and P. cuspidatum, has been proposed to have anticancer activity. This activity has been suggested to be associated with mitochondrial injury due to the induction of mitochondrial permeability transition pore (mPTP) opening. Read More

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http://dx.doi.org/10.1002/biof.1462DOI Listing
January 2019
2 Reads
4.592 Impact Factor

Dietary ursolic acid improves health span and life span in male Drosophila melanogaster.

Biofactors 2019 Mar 29;45(2):169-186. Epub 2018 Nov 29.

Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.

The health and life span of Drosophila melanogaster are partly determined by intestinal barrier integrity, metabolic rate as well as stress response and the expression of longevity-associated genes, depending on genetic and dietary factors. Ursolic acid (UA) is a naturally occurring triterpenoid exhibiting potential antimicrobial, anti-inflammatory, and antiobesity activity and counteracting age-related deficits in muscle strength. In this study, UA was dietarily administered to w D. Read More

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http://dx.doi.org/10.1002/biof.1467DOI Listing
March 2019
7 Reads

Leptin decreases circulating inflammatory IL-6 and MCP-1 in mice.

Biofactors 2019 Jan 29;45(1):43-48. Epub 2018 Nov 29.

Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.

Leptin influences inflammation and immune response. Dose-dependent effects of leptin on biomarkers of inflammation have not been studied in vivo, so far. Leptin-deficient low-density lipoprotein receptor (LDLR) knockout (LDLR ;ob/ob) female mice were treated with three different leptin doses or saline for 12 weeks. Read More

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http://dx.doi.org/10.1002/biof.1457DOI Listing
January 2019
2 Reads

Vicenin-2 acts as a radiosensitizer of the non-small cell lung cancer by lowering Akt expression.

Biofactors 2019 Mar 29;45(2):200-210. Epub 2018 Nov 29.

Cancer and Radiation Countermeasures Unit, Department of Biochemistry, North-Eastern Hill University, Shillong, India.

Non-small cell lung cancer (NSCLC) has a very high rate of incidence and is resistant to chemo- and radiotherapy. Vicenin-2 (VCN-2) is a flavonoid obtained from Ocimum sanctum L. and it has been reported to have radioprotective, anticancer, and radiosensitizing properties. Read More

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http://doi.wiley.com/10.1002/biof.1472
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http://dx.doi.org/10.1002/biof.1472DOI Listing
March 2019
6 Reads

Curcumin supplementation increases survival and lifespan in Drosophila under heat stress conditions.

Biofactors 2018 Nov 29;44(6):577-587. Epub 2018 Nov 29.

Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Zhejiang, Hangzhou, China.

Harsh climate induces physiological stress thus compromising organismal survival. Our previous studies demonstrated that curcumin (CUR) supplementation increased survival of turtle under heat stress (HS). Here, we span this work to investigate the survival and lifespan of HS Drosophila fed a diet supplemented with CUR. Read More

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http://dx.doi.org/10.1002/biof.1454DOI Listing
November 2018
3 Reads

Luteolin-mediated Kim-1/NF-kB/Nrf2 signaling pathways protects sodium fluoride-induced hypertension and cardiovascular complications.

Biofactors 2018 Nov 26;44(6):518-531. Epub 2018 Nov 26.

Department of Environmental and Interdisciplinary Sciences, College of Science, Engineering and Technology, NSB303, Sr. Scientist & Head, Vascular Biology Unit, Center for Cardiovascular Diseases, COPHS, Texas Southern University, Houston, TX, USA.

The use of sodium fluoride (NaF) as a major ingredient for tooth paste, mouth wash, and mouth rinse has become inevitable in our day-to-day life. However, flavonoids such as Luteolin might be of great value in the prevention of toxicity associated with accidental or inevitable ingestion of NaF. In the study, 40 male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Read More

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http://doi.wiley.com/10.1002/biof.1449
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http://dx.doi.org/10.1002/biof.1449DOI Listing
November 2018
14 Reads

Systemic and local hepcidin as emerging and important peptides in renal homeostasis and pathology.

Authors:
Driton Vela

Biofactors 2019 Mar 21;45(2):118-134. Epub 2018 Nov 21.

Department of Physiology, Faculty of Medicine, University of Prishtina, Prishtina, Kosova.

Recent data suggest that the importance of hepcidin goes beyond its classical role in controlling systemic iron metabolism. Local hepcidins are emerging as important peptides for organ homeostasis in the brain, heart, blood vessels, and in cancer as well. Similarly, accumulating data indicate that hepcidin does seem to be an important factor in renal homeostasis. Read More

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http://dx.doi.org/10.1002/biof.1468DOI Listing
March 2019
18 Reads

Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice.

Biofactors 2019 Mar 12;45(2):187-199. Epub 2018 Nov 12.

Department of Anatomy, Shandong University School of Basic medicine, Jinan, Shandong, China.

Alcohol addiction can cause brain dysfunction and many other diseases. Recently, increasing evidences have suggested that gut microbiota plays a vital role in regulating alcohol addiction. However, the exact mechanism has not yet been elucidated. Read More

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http://doi.wiley.com/10.1002/biof.1469
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http://dx.doi.org/10.1002/biof.1469DOI Listing
March 2019
27 Reads

HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NFκB in HepG2 cells.

Biofactors 2018 Nov 30;44(6):570-576. Epub 2018 Oct 30.

Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background/aim: High mobility group box 1 protein (HMGB1) is functionally dynamic and pleiotropic molecule, it has the potential to promote both cell survival and death by regulating multiple signaling pathways, including inflammation and apoptosis. This study aimed at investigating the role of silencing HMGB1 on tumor cells apoptosis and pro-inflammatory proteins expression in hepatocellular HepG2 cancer cells.

Methods: HepG2 cells was transfected with si-RNA HMGB1, and the effect on pro-apoptotic proteins expressions like Bax, Bcl2, and pro-inflammatory cytokines like, p65-NFκB, and Cyclooxygenase-2 (Cox2) was assessed using western blot, and also cells apoptosis and proliferation was assessed using annexin V FITC and Calcien AM expression in flow cytometry and fluorescence. Read More

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http://doi.wiley.com/10.1002/biof.1456
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http://dx.doi.org/10.1002/biof.1456DOI Listing
November 2018
8 Reads

Addition of high load of lysophosphatidic acid to standard and high-fat chows causes no significant changes of its circulating and peripheral tissue levels but affects body weight and visceral fat mass of mice.

Biofactors 2018 Nov 16;44(6):548-557. Epub 2018 Oct 16.

Department of Pharmaceutical Health Chemistry, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan.

Oral administration of lysophosphatidic acid (LPA), a critical intercellular lipid mediator, exerts wound healing and antiulcer effects on gastrointestinal system. To evaluate effects of food-derived LPA on body homeostasis, we measured LPA levels by liquid chromatography-tandem mass spectrometry in chows, feces, plasma, liver, and visceral fat of mice fed a normal or high-fat chow supplemented with or without LPA-rich soybean phospholipids for 30 days. Reductions in daily body weight gains and visceral fat mass were mainly related to lower chow intake by mice fed the LPA-rich high-fat chow, whereas reduced body weight gains and fat mass were mainly related to decreased intestinal triacylglycerol absorption in mice fed LPA-rich chow. Read More

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http://doi.wiley.com/10.1002/biof.1451
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http://dx.doi.org/10.1002/biof.1451DOI Listing
November 2018
4 Reads

Withaferin A attenuates bleomycin-induced scleroderma by targeting FoxO3a and NF-κβ signaling: Connecting fibrosis and inflammation.

Biofactors 2018 Nov 27;44(6):507-517. Epub 2018 Oct 27.

Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, 500037, India.

Scleroderma is an inflammatory autoimmune disease which begins with inflammation due to tissue injury and advances to progressive accumulation of extracellular matrix resulting in scarring and hardening of the skin. Inflammation is a salutary response to tissue injury caused by varied factors. While inflammation is required for systematic wound healing, dysregulated chronic inflammation often leads to tissue scarring. Read More

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http://dx.doi.org/10.1002/biof.1446DOI Listing
November 2018
1 Read

Flavonoids as putative modulators of Δ4-, Δ5-, and Δ6-desaturases: Studies in cultured hepatocytes, myocytes, and adipocytes.

Biofactors 2018 Sep;44(5):485-495

Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.

This study was conducted to screen flavonoids for affecting expression of desaturases involved in omega-3 fatty acid synthesis and ceramide (CER) metabolism. To this end, cultured HepG2 hepatocytes, C2C12 myocytes, and 3T3-L1 adipocytes were treated with nontoxic concentrations of 12 selected flavonoids and expression of Δ4-, Δ5-, and Δ6-desaturases (DEGS1, FADS1, and FADS2, respectively) was determined. The flavonoids tested were more cytotoxic to HepG2 and 3T3-L1 than to C2C12 cells. Read More

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http://doi.wiley.com/10.1002/biof.1443
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http://dx.doi.org/10.1002/biof.1443DOI Listing
September 2018
16 Reads