Construction of a liver sinusoid based on the laminar flow on chip and self-assembly of endothelial cells.
Biofabrication 2018 Feb 20;10(2):025010. Epub 2018 Feb 20.
Graduate School at Shenzhen, Tsinghua University, Shenzhen, People's Republic of China. Open FIESTA Center, Tsinghua University, Shenzhen 518055, People's Republic of China. Department of Mechanical Engineering and Mechanics, Tsinghua University, Beijing, People's Republic of China.
The liver is one of the main metabolic organs, and nearly all ingested drugs will be metabolized by the liver. Only a small fraction of drugs are able to come onto the market during drug development, and hepatic toxicity is a major cause for drug failure. Since drug development is costly in both time and materials, an in vitro liver model that can accelerate bioreactions in the liver and reduce drug consumption is imperative in the pharmaceutical industry. Read More