126,427 results match your criteria Bioengineering Basel Switzerland[Journal]


Zirconium-based metallic glass and zirconia coatings to inhibit bone formation on titanium.

Biomed Mater 2020 Jul 2. Epub 2020 Jul 2.

Central Electrochemical Research Institute CSIR, Karaikudi, Tamil Nadu, INDIA.

Surface modified commercially pure titanium with Zr based thin film metallic glasses (Zr-TFMGs) and ZrO2 thin films were surgically implanted into tibia of rat; the bone formation was analyzed to examine the performance of the coatings as a biomaterial. Zr-TFMGs and ZrO2 thin films were coated on Cp-Ti substrates to monitor the control of assimilation in vitro and in vivo. The microstructural and elemental analyses were carried out for the as deposited thin films by X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy. Read More

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http://dx.doi.org/10.1088/1748-605X/aba23aDOI Listing

c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism.

Colloids Surf B Biointerfaces 2020 Jun 25;194:111211. Epub 2020 Jun 25.

Department of Applied Physiology, School of Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan.

Green synthesis of metal-encased nutraceutical nano-hybrids has been a target for research over the last few years. In the present investigation, we have reported temperature dependent facile synthesis of silver nanoparticles using FDA approved c phycocyanin (cPC). The cPC conjugated silver nanoparticles (AgcPCNPs) were characterized by TEM, Zeta Potential, UV-vis, XPS, FTIR, and CD Spectroscopy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111211DOI Listing

Salvage surgery in head and neck cancer: External validation of predictors of disease-specific survival.

Oral Oncol 2020 Jun 29;109:104876. Epub 2020 Jun 29.

Department of Otolaryngology-Head and Neck Surgery, University Hospital de la Santa Creu i Sant Pau, Universitat Autonòma de Barcelona, Barcelona, Spain.

Objective: Salvage surgery in recurrent head and neck squamous cell carcinoma (HNSCC) is associated with poor outcomes. There is great interest to better identify suitable surgical patients. This study aimed to validate the proposal of Hamoir et al. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104876DOI Listing

A Systematic Analysis of Protein-Carbohydrate Interactions in the PDB.

Glycobiology 2020 Jul 2. Epub 2020 Jul 2.

Departments of Biological Sciences, Chemistry, Bioengineering, and Computer Sciences and Engineering, Lehigh University, Bethlehem, PA 18015, USA.

Protein-carbohydrate interactions underlie essential biological processes. Elucidating the mechanism of protein-carbohydrate recognition is a prerequisite for modeling and optimizing protein-carbohydrate interactions, which will help in discovery of carbohydrate-derived therapeutics. In this work, we present a survey of a curated database consisting of 6,402 protein-carbohydrate complexes in the PDB. Read More

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http://dx.doi.org/10.1093/glycob/cwaa062DOI Listing

Computational models to improve surveillance for cassava brown streak disease and minimize yield loss.

PLoS Comput Biol 2020 Jul 2;16(7):e1007823. Epub 2020 Jul 2.

Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom.

Cassava brown streak disease (CBSD) is a rapidly spreading viral disease that affects a major food security crop in sub-Saharan Africa. Currently, there are several proposed management interventions to minimize loss in infected fields. Field-scale data comparing the effectiveness of these interventions individually and in combination are limited and expensive to collect. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1007823DOI Listing

Evaluation of Patient Motivation and Satisfaction During Technology-Assisted Rehabilitation: An Experiential Review.

Games Health J 2020 Jul 2. Epub 2020 Jul 2.

Service of Bioengineering, Istituti Clinici Scientifici Maugeri, IRCCS, Veruno, Italy.

The aim of this experiential review is to explore the state of the art of the literature regarding the evaluation tools available for assessment of patient motivation and satisfaction during technology-assisted rehabilitation (robot rehabilitation, virtual reality rehabilitation, and serious games rehabilitation). A systematic search of the peer-reviewed literature published from January 1990 to August 2019 was conducted. The protocol for this review was registered in PROSPERO and carried out in accordance with the PRISMA recommendations. Read More

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http://dx.doi.org/10.1089/g4h.2020.0024DOI Listing

A comparison of the energy costs with use of different types of manual wheelchair in disabled persons.

G Ital Med Lav Ergon 2020 Mar;42(1):55-59

Unit of Occupational Therapy and Ergonomics, Istituti Clinici Scientifici Maugeri, Institute of Pavia-Montescano.

Summary: The energy cost of physical activity is a well-documented field of research both in non-disabled subjects and in subjects with physical disabilities, in particular spinal cord lesions. The aim of this study was, therefore, to investigate the energy cost and subjective fatigue in disabled persons who make daily use of a manual wheelchair by comparing three different types of wheelchair (standard, lightweight and ultra-light) in order to obtain indices useful for prescribing the most effective and appropriate wheelchairaid for the individual patient. The study was carried out on 18 patients affected by paraplegia or paraparesis due to spinal cord injury at different levels. Read More

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Quantitative Analysis of Protein Self-Association by Sedimentation Velocity.

Curr Protoc Protein Sci 2020 Sep;101(1):e109

Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland.

Sedimentation velocity analytical ultracentrifugation is a powerful classical method to study protein self-association processes in solution based on the size-dependent macromolecular migration in the centrifugal field. This technique can elucidate the assembly scheme, measure affinities ranging from picomolar to millimolar K , and in favorable cases provide information on oligomer lifetimes and hydrodynamic shape. The present step-by-step protocols detail the essential steps of instrument calibration, experimental setup, and data analysis. Read More

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http://dx.doi.org/10.1002/cpps.109DOI Listing
September 2020

[When stemness genes meet skin graft bioengineering: focus on KLF4].

Med Sci (Paris) 2020 Jun-Jul;36(6-7):565-568. Epub 2020 Jul 2.

Laboratoire de génomique et radiobiologie de la kératinopoïèse, CEA/DRF/IBFJ/IRCM, 2 rue Gaston Crémieux, 91000 Évry, France Inserm U967, Fontenay-aux-Roses ; Université Paris-Diderot, Université Paris-Saclay, France.

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http://dx.doi.org/10.1051/medsci/2020101DOI Listing

Risk of Prostate Cancer after a Negative MRI-Guided Biopsy.

J Urol 2020 Jul 2:101097JU0000000000001232. Epub 2020 Jul 2.

Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.

Purpose: An MRI-guided biopsy (MRGB), which reveals no cancer, may impart reassurance beyond that offered by ultrasound-guided biopsy. However, follow-up of men after a negative MRGB has been mostly by PSA testing; reports of follow-up tissue confirmation are few. We investigated incidence of clinically significant prostate cancer (csPCa) in such men who, because of persistent cancer suspicion, subsequently underwent a repeat MRGB. Read More

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http://dx.doi.org/10.1097/JU.0000000000001232DOI Listing

Study on immunoregulation function of peony seed proteolysis product in mice.

J Food Biochem 2020 Jul 2:e13353. Epub 2020 Jul 2.

College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, P.R. China.

To explore the immunoregulatory function of peony seed proteolysis product in mice, the protein from peony seed meal was extracted and hydrolyzed with bromelain. The peony seed proteolysis product was fed to mice at three different doses of 0.25, 0. Read More

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http://dx.doi.org/10.1111/jfbc.13353DOI Listing

Removal of the N-terminal methionine improves the sweetness of the recombinant expressed sweet-tasting protein brazzein and its mutants in Escherichia coli.

J Food Biochem 2020 Jul 2:e13354. Epub 2020 Jul 2.

School of Food Science & Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.

The sweet-tasting protein brazzein is the smallest sweet protein with high sweet potency. Overexpression of this protein in a heterogenous host is an essential way for its production in food industry. In this study, the gene of minor form brazzein was cloned into the pET-SUMO vector with optimized codon usage and expressed in E. Read More

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http://dx.doi.org/10.1111/jfbc.13354DOI Listing

Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery.

Chem Commun (Camb) 2020 Jul 2. Epub 2020 Jul 2.

Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.

A structure-determined gold-levonorgestrel nanocluster, Au10(C21H27O2)10 (Au10NC), has been obtained via solvent induced crystal transformation from Au8(C21H27O2)8 (Au8NC), accompanied by a fluorescence color change from green to yellow. A cationic polymer, poly(allylamine hydrochloride) (PAH), was chosen to assemble with Au10NC to prepare monodisperse and stable particles (Au10NC-PAH) with an increased quantum yield of 49.8%. Read More

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http://dx.doi.org/10.1039/d0cc03498cDOI Listing

Does cycling induced by functional electrical stimulation enhance motor recovery in the subacute phase after stroke? A systematic review and meta-analysis.

Clin Rehabil 2020 Jul 2:269215520938423. Epub 2020 Jul 2.

Neuroengineering and Medical Robotics Laboratory, Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, MI, Italy.

Objective: To investigate the effects of cycling with functional electrical stimulation on walking, muscle power and tone, balance and activities of daily living in subacute stroke survivors.

Data Sources: Ten electronic databases were searched from inception to February 2020.

Review Methods: Inclusion criteria were: subacute stroke survivors (<6 months since stroke), an experimental group performing any type of cycling training with electrical stimulation, alone or in addition to usual care, and a control group performing usual care alone. Read More

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http://dx.doi.org/10.1177/0269215520938423DOI Listing

Tissue Ingrowth Markedly Reduces Mechanical Anisotropy and Stiffness in Fibre Direction of Highly Aligned Electrospun Polyurethane Scaffolds.

Cardiovasc Eng Technol 2020 Jul 1. Epub 2020 Jul 1.

Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Private Bag X3, Observatory, 7935, South Africa.

Purpose: The lack of long-term patency of synthetic vascular grafts currently available on the market has directed research towards improving the performance of small diameter grafts. Improved radial compliance matching and tissue ingrowth into the graft scaffold are amongst the main goals for an ideal vascular graft.

Methods: Biostable polyurethane scaffolds were manufactured by electrospinning and implanted in subcutaneous and circulatory positions in the rat for 7, 14 and 28 days. Read More

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http://dx.doi.org/10.1007/s13239-020-00475-xDOI Listing

Establishment of a clinical SPECT/CT protocol for imaging of Tb.

EJNMMI Phys 2020 Jul 1;7(1):45. Epub 2020 Jul 1.

Department of Radiation Physics, Institution of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: It has been proposed, and preclinically demonstrated, that Tb is a better alternative to Lu for the treatment of small prostate cancer lesions due to its high emission of low-energy electrons. Tb also emits photons suitable for single-photon emission computed tomography (SPECT) imaging. This study aims to establish a SPECT protocol for Tb imaging in the clinic. Read More

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http://dx.doi.org/10.1186/s40658-020-00314-xDOI Listing

Assessing neuraxial microstructural changes in a transgenic mouse model of early stage Amyotrophic Lateral Sclerosis by ultra-high field MRI and diffusion tensor metrics.

Animal Model Exp Med 2020 Jun 16;3(2):117-129. Epub 2020 Apr 16.

Department of Bioengineering University of Illinois at Chicago Chicago IL USA.

Objective: Cell structural changes are one of the main features observed during the development of amyotrophic lateral sclerosis (ALS). In this work, we propose the use of diffusion tensor imaging (DTI) metrics to assess specific ultrastructural changes in the central nervous system during the early neurodegenerative stages of ALS.

Methods: Ultra-high field MRI and DTI data at 17. Read More

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http://dx.doi.org/10.1002/ame2.12112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323706PMC

Cell populations and muscle fiber morphology associated with acute and chronic muscle degeneration in lumbar spine pathology.

JOR Spine 2020 Jun 8;3(2):e1087. Epub 2020 Apr 8.

Department of Orthopaedic Surgery University of California San Diego San Diego California USA.

Many chronic musculoskeletal conditions are associated with loss of muscle volume and quality, resulting in functional decline. While atrophy has long been implicated as the mechanism of muscle loss in these conditions, recent evidence has emerged demonstrating a degenerative phenotype of muscle loss consisting of disrupted muscle fiber membranes, infiltration of cells into muscle fibers, and as previously describer, possible replacement of muscle fibers by adipose tissue. Here, we use human lumbar spine pathology as a model system to provide a more comprehensive analysis of the morphological features of this mode of muscle loss between early and late stages of disease, including an analysis of the cell populations found in paraspinal muscle biopsies from humans with acute vs chronic lumbar spine pathology. Read More

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http://dx.doi.org/10.1002/jsp2.1087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323470PMC

Restoration of physiologic loading modulates engineered intervertebral disc structure and function in an in vivo model.

JOR Spine 2020 Jun 13;3(2):e1086. Epub 2020 May 13.

Translational Musculoskeletal Research Center Corporal Michael J. Crescenz VA Medical Center Philadelphia Pennsylvania USA.

Tissue-engineered whole disc replacements are an emerging treatment strategy for advanced intervertebral disc degeneration. A challenge facing the translation of tissue-engineered disc replacement to clinical use are the opposing needs of initial immobilization to advantage integration contrasted with physiologic loading and its anabolic effects. Here, we utilize our established rat tail model of tissue engineered disc replacement with external fixation to study the effects of remobilization at two time points postimplantation on engineered disc structure, composition, and function. Read More

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http://dx.doi.org/10.1002/jsp2.1086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323465PMC

Multiparametric MRI characterization of level dependent differences in lumbar muscle size, quality, and microstructure.

JOR Spine 2020 Jun 3;3(2):e1079. Epub 2020 Feb 3.

Department of Bioengineering University of California San Diego California.

Magnetic resonance imaging (MRI) is a diagnostic tool that can be used to noninvasively assess lumbar muscle size and fatty infiltration, important biomarkers of muscle health. Diffusion tensor imaging (DTI) is an MRI technique that is sensitive to muscle microstructural features such as fiber size (an important biomarker of muscle health), which is typically only assessed using invasive biopsy techniques. The goal of this study was to establish normative values of level-dependent lumbar muscle size, fat signal fraction, and restricted diffusion assessed by MRI in a highly active population. Read More

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http://dx.doi.org/10.1002/jsp2.1079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323468PMC

Concentrated Growth Factor Matrices Prepared Using Silica-Coated Plastic Tubes Are Distinguishable From Those Prepared Using Glass Tubes in Platelet Distribution: Application of a Novel Near-Infrared Imaging-Based, Quantitative Technique.

Front Bioeng Biotechnol 2020 16;8:600. Epub 2020 Jun 16.

Division of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan.

Platelet-rich fibrin (PRF) matrices were originally prepared using plain glass tubes without the aid of coagulation factors because coagulation factor XII is activated by glass surfaces. Recently, the use of silica-coated plastic tubes as a substitute of glass tubes has been recommended for PRF preparation. This recommendation is owing not only to the shortage of glass tubes for medical use in the market, but also the higher coagulation activity of silica-coated plastic tubes and equal quality of PRF. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310272PMC

Scaffold Implant Into the Epididymal Adipose Tissue Protects Mice From High Fat Diet Induced Ectopic Lipid Accumulation and Hyperinsulinemia.

Front Bioeng Biotechnol 2020 16;8:562. Epub 2020 Jun 16.

Biomedical Engineering Program, University of South Carolina, Columbia, SC, United States.

Ectopic lipid accumulation, the deposition of lipids in lean tissue, is linked to type 2 diabetes through an association with insulin resistance. It occurs when adipose tissue fails to meet lipid storage needs and there is lipid spillover into tissues not equipped to store them. Ectopic lipid contributes to organ dysfunction because lipids can interfere with insulin signaling and other signaling pathways. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308717PMC

Upgrading end-of-line residues of the red seaweed to polyhydroxyalkanoates using .

Biotechnol Rep (Amst) 2020 Sep 16;27:e00491. Epub 2020 Jun 16.

iBB- Institute for Bioengineering and Biosciences, Bioengineering Department, Instituto Superior Técnico, Universidade de Lisboa, Portugal.

Agar extraction from and red seaweed species produces hundred thousand ton of carbohydrate-rich residues annually. waste biomass obtained after agar extraction, still contained 44.2 % w/w total carbohydrates (dry-weight basis). Read More

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http://dx.doi.org/10.1016/j.btre.2020.e00491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317225PMC
September 2020

Clinical photoacoustic imaging.

Photoacoustics 2020 Sep 17;19:100196. Epub 2020 Jun 17.

Department of Radiology, Molecular Imaging Program at Stanford (MIPS), The Bio-X Program, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.pacs.2020.100196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317224PMC
September 2020

The Impact of Vision Loss on Allocentric Spatial Coding.

Front Neurosci 2020 16;14:565. Epub 2020 Jun 16.

Unit for Visually Impaired People, Istituto Italiano di Tecnologia, Genoa, Italy.

Several works have demonstrated that visual experience plays a critical role in the development of allocentric spatial coding. Indeed, while children with a typical development start to code space by relying on allocentric landmarks from the first year of life, blind children remain anchored to an egocentric perspective until late adolescence. Nonetheless, little is known about when and how visually impaired children acquire the ability to switch from an egocentric to an allocentric frame of reference across childhood. Read More

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http://dx.doi.org/10.3389/fnins.2020.00565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308590PMC

Physiological blood-brain transport is impaired with age by a shift in transcytosis.

Nature 2020 Jul 1. Epub 2020 Jul 1.

ChEM-H, Stanford University, Stanford, CA, USA.

The vascular interface of the brain, known as the blood-brain barrier (BBB), is understood to maintain brain function in part via its low transcellular permeability. Yet, recent studies have demonstrated that brain ageing is sensitive to circulatory proteins. Thus, it is unclear whether permeability to individually injected exogenous tracers-as is standard in BBB studies-fully represents blood-to-brain transport. Read More

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http://dx.doi.org/10.1038/s41586-020-2453-zDOI Listing

Pre-evaluation of humoral immune response of Bactrian camels by the quantification of Th2 cytokines using real-time PCR.

J Biomed Res 2020 Jan 23:1-8. Epub 2020 Jan 23.

Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public or

With the increasing immunological studies on camels due to the advantage of their single-chain antibodies for humanizations, it is demanding to develop an easy-to-handle evaluation method of their humoral immune response before proceeding with immunization of foreign antigens that may be toxic to camels. In this study, we quantitatively determined the expression levels of T-helper 2 (Th2) cytokines in peripheral blood lymphocytes obtained from Bactrian camels by real-time PCR. The recorded kinetic profiles resulting from the immunization of ovalbumin (OVA) indicated that after immunization, Th2 cytokines including interleukin (IL) families such as IL-4, IL-10, and IL-13 in the camels were up-regulated by a factor of 1. Read More

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http://dx.doi.org/10.7555/JBR.34.20190035DOI Listing
January 2020

Dynamic neural and glial responses of a head-specific model for traumatic brain injury in .

Proc Natl Acad Sci U S A 2020 Jul 1. Epub 2020 Jul 1.

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104;

Traumatic brain injury (TBI) is the strongest environmental risk factor for the accelerated development of neurodegenerative diseases. There are currently no therapeutics to address this due to lack of insight into mechanisms of injury progression, which are challenging to study in mammalian models. Here, we have developed and extensively characterized a head-specific approach to TBI in , a powerful genetic system that shares many conserved genes and pathways with humans. Read More

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http://dx.doi.org/10.1073/pnas.2003909117DOI Listing

Time for a Next-Generation Nuclear Medicine Gamma Camera?

Authors:
I George Zubal

J Nucl Med 2020 Jul;61(7):16N

Program Director for Nuclear Medicine, CT, and X-Ray, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD.

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An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients.

Sci Transl Med 2020 Jul;12(550)

Department of Materials Science and Engineering, Stanford University, Stanford, CA 94025, USA.

Insulin has been used to treat diabetes for almost 100 years; yet, current rapid-acting insulin formulations do not have sufficiently fast pharmacokinetics to maintain tight glycemic control at mealtimes. Dissociation of the insulin hexamer, the primary association state of insulin in rapid-acting formulations, is the rate-limiting step that leads to delayed onset and extended duration of action. A formulation of insulin monomers would more closely mimic endogenous postprandial insulin secretion, but monomeric insulin is unstable in solution using present formulation strategies and rapidly aggregates into amyloid fibrils. Read More

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http://dx.doi.org/10.1126/scitranslmed.aba6676DOI Listing

Cardiopulmonary exercise testing in chronic heart failure patients treated with beta-blockers: Still a valid prognostic tool.

Int J Cardiol 2020 Apr 11. Epub 2020 Apr 11.

Heart Failure Unit, Cardiology Department, Polichirurgico Hospital G. Da Saliceto, Piacenza, Italy.

Background: The advent of beta-blockers (BBs) has revolutionized the treatment of heart failure due to left ventricular dysfunction (HFrEF), as these drugs increase survival and reduce hospitalization without a significant impact on exercise tolerance. In this new prognostic scenario, the predictive role of cardiopulmonary exercise testing (CPET) has been questioned.

Aim: To evaluate the predictive value of CPET and "traditional" derived and calculated risk parameters in HFrEF patients on BBs. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.04.020DOI Listing

Translational data analytics in exposure science and environmental health: a citizen science approach with high school students.

Environ Health 2020 Jul 1;19(1):73. Epub 2020 Jul 1.

Department of Civil, Environmental and Geodetic Engineering, College of Engineering, The Ohio State University, 2070 Neil Avenue, 483A Hitchcock Hall, Columbus, OH, 43210, USA.

Background: Translational data analytics aims to apply data analytics principles and techniques to bring about broader societal or human impact. Translational data analytics for environmental health is an emerging discipline and the objective of this study is to describe a real-world example of this emerging discipline.

Methods: We implemented a citizen-science project at a local high school. Read More

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http://dx.doi.org/10.1186/s12940-020-00627-5DOI Listing

Invertible generalized synchronization: A putative mechanism for implicit learning in neural systems.

Chaos 2020 Jun;30(6):063133

Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Regardless of the marked differences between biological and artificial neural systems, one fundamental similarity is that they are essentially dynamical systems that can learn to imitate other dynamical systems whose governing equations are unknown. The brain is able to learn the dynamic nature of the physical world via experience; analogously, artificial neural systems such as reservoir computing networks (RCNs) can learn the long-term behavior of complex dynamical systems from data. Recent work has shown that the mechanism of such learning in RCNs is invertible generalized synchronization (IGS). Read More

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http://dx.doi.org/10.1063/5.0004344DOI Listing

Toward rapid infectious disease diagnosis with advances in surface-enhanced Raman spectroscopy.

J Chem Phys 2020 Jun;152(24):240902

Department of Materials Science and Engineering, Stanford University School of Engineering, Stanford, California 94305, USA.

In a pandemic era, rapid infectious disease diagnosis is essential. Surface-enhanced Raman spectroscopy (SERS) promises sensitive and specific diagnosis including rapid point-of-care detection and drug susceptibility testing. SERS utilizes inelastic light scattering arising from the interaction of incident photons with molecular vibrations, enhanced by orders of magnitude with resonant metallic or dielectric nanostructures. Read More

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http://dx.doi.org/10.1063/1.5142767DOI Listing

On the stability and necessary electrophoretic mobility of bare oil nanodroplets in water.

J Chem Phys 2020 Jun;152(24):241104

Laboratory for Fundamental BioPhotonics, Institute of Bioengineering (IBI), Institute of Materials Science (IMX) and Engineering, School of Engineering (STI), and Lausanne Centre for Ultrafast Science, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

Hydrophobic oil droplets, particles, and air bubbles can be dispersed in water as kinetically stabilized dispersions. It has been established since the 19th century that such objects harbor a negative electrostatic potential roughly twice larger than the thermal energy. The source of this charge continues to be one of the core observations in relation to hydrophobicity, and its molecular explanation is still debated. Read More

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http://dx.doi.org/10.1063/5.0009640DOI Listing

Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides-A Review.

Pathogens 2020 Jun 29;9(7). Epub 2020 Jun 29.

Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, H-1581 Budapest, P.O. Box 22, Hungary.

Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are discussed. Arguments for, and against, pessimistic forecasts on a fatal "post-antibiotic era" are evaluated. Read More

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http://dx.doi.org/10.3390/pathogens9070522DOI Listing

Computational Modeling of the Liver Arterial Blood Flow for Microsphere Therapy: Effect of Boundary Conditions.

Bioengineering (Basel) 2020 Jun 29;7(3). Epub 2020 Jun 29.

Department of Biomedical Engineering, University of California Davis, One Shields Ave., Davis, CA 95616, USA.

Transarterial embolization is a minimally invasive treatment for advanced liver cancer using microspheres loaded with a chemotherapeutic drug or radioactive yttrium-90 (Y) that are injected into the hepatic arterial tree through a catheter. For personalized treatment, the microsphere distribution in the liver should be optimized through the injection volume and location. Computational fluid dynamics (CFD) simulations of the blood flow in the hepatic artery can help estimate this distribution if carefully parameterized. Read More

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http://dx.doi.org/10.3390/bioengineering7030064DOI Listing

Protein-Based Nanoparticles as Drug Delivery Systems.

Pharmaceutics 2020 Jun 29;12(7). Epub 2020 Jun 29.

Department of Biotechnology and Bioengineering, Kangwon National University, Chuncheon 24341, Korea.

Nanoparticles have been extensively used as carriers for the delivery of chemicals and biomolecular drugs, such as anticancer drugs and therapeutic proteins. Natural biomolecules, such as proteins, are an attractive alternative to synthetic polymers commonly used in nanoparticle formulation because of their safety. In general, protein nanoparticles offer many advantages, such as biocompatibility and biodegradability. Read More

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http://dx.doi.org/10.3390/pharmaceutics12070604DOI Listing

Linear Relationships between Partition Coefficients of Different Organic Compounds and Proteins in Aqueous Two-Phase Systems of Various Polymer and Ionic Compositions.

Polymers (Basel) 2020 Jun 29;12(7). Epub 2020 Jun 29.

Cleveland Daignostics, 3615 Superior Ave., Cleveland, OH 44114, USA.

Analysis of the partition coefficients of small organic compounds and proteins in different aqueous two-phase systems under widely varied ionic compositions shows that logarithms of partition coefficients for any three compounds or proteins or two organic compounds and one protein are linearly interrelated, although for protein(s) there are ionic compositions when the linear fit does not hold. It is suggested that the established interrelationships are due to cooperativity of different types of solute-solvent interactions in aqueous media. This assumption is confirmed by analysis of distribution coefficients of various drugs in octanol-buffer systems with varied ionic compositions of the buffer. Read More

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http://dx.doi.org/10.3390/polym12071452DOI Listing

The Problems with Risk Prediction during an Emergency Medical Admission Using Laboratory Data - Evidence from Potassium.

Acute Med 2019 ;18(1):20-26

Department of Internal Medicine, St James's Hospital, Dublin 8, Ireland.

Background: The prediction of clinical outcomes using biochemical markers is an important tool.

Methods: We calculated a risk score for all emergency admissions 2002-2017. We related potassium and mortality in a multivariable fractional polynomial model. Read More

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January 2019

Impact of Navigated Task-specific fMRI on Direct Cortical Stimulation.

J Neurol Surg A Cent Eur Neurosurg 2020 Jul 1. Epub 2020 Jul 1.

Faculdade de Ciências da Universidade de Lisboa, Instituto de Biofísica e Engenharia Biomédica, Lisboa, Portugal.

Background And Study Aims:  Cortical mapping (CM) with direct cortical stimulation (DCS) in awake craniotomy is used to preserve cognitive functions such as language. Nevertheless, patient collaboration during this procedure is influenced by previous neurological symptoms and growing discomfort with DCS duration. Our study aimed to evaluate the impact of navigated task-specific functional magnetic resonance imaging (nfMRI) on the practical aspects of DCS. Read More

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http://dx.doi.org/10.1055/s-0040-1712496DOI Listing

Bio-inspired protective structures for marine applications.

Bioinspir Biomim 2020 Jul 1. Epub 2020 Jul 1.

Department of Engineering, University of Messina, Messina, ITALY.

Materials and structures for marine applications are often required to combine high mechanical performance with lightness, but traditional solutions are not always adequate to the scope. The application of biomimetic science could provide innovative and efficient solutions, whose research is the aim of the present paper. In the current work, bamboo samples were subjected to impact both on the outside and on the inside surface. Read More

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http://dx.doi.org/10.1088/1748-3190/aba1d1DOI Listing

A novel rat robot controlled by electrical stimulation of the nigrostriatal pathway.

Neurosurg Focus 2020 Jul;49(1):E11

2Department of Physiology, College of Medicine, Hallym University, Chuncheon.

Objective: Artificial manipulation of animal movement could offer interesting advantages and potential applications using the animal's inherited superior sensation and mobility. Although several behavior control models have been introduced, they generally epitomize virtual reward-based training models. In this model, rats are trained multiple times so they can recall the relationship between cues and rewards. Read More

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http://dx.doi.org/10.3171/2020.4.FOCUS20150DOI Listing

Water electrification: Principles and applications.

Authors:
Chang Q Sun

Adv Colloid Interface Sci 2020 Jun 6;282:102188. Epub 2020 Jun 6.

School of EEE, Nanyang Technological University, 639798, Singapore; School of Material Science and Engineering, Jilin University, Changchun 130022, China. Electronic address:

Deep engineering of liquid water by charge and impurity injection, charged support, current flow, hydrophobic confinement, or applying a directional field has becoming increasingly important to the mankind toward overcoming energy and environment crisis. One can mediate the processes or temperatures of molecular evaporation for clean water harvesting, HO bond dissociation for H fuel generation, solidification for living-organism cryopreservation, structure stiffening for bioengineering, etc., with mechanisms being still puzzling. Read More

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http://dx.doi.org/10.1016/j.cis.2020.102188DOI Listing

Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives.

Semin Cancer Biol 2020 Jun 28. Epub 2020 Jun 28.

Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, 781 039, Assam, India; DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Indian Institute of Technology (IIT) Guwahati, Guwahati, 781 039, Assam, India. Electronic address:

Despite significant advancements made in the treatment of cancer during the past several decades, it remains one of the leading causes of death worldwide killing approximately 9.6 million people annually. The major challenge for therapeutic success is the development of chemoresistance in cancer cells against conventional chemotherapeutic agents via modulation of numerous survival and oncogenic signaling pathways. Read More

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http://dx.doi.org/10.1016/j.semcancer.2020.06.014DOI Listing

Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair.

Cell Rep 2020 Jun;31(13):107828

Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA. Electronic address:

Lung alveolar epithelium is composed of alveolar type I (AT1) and type II (AT2) cells. AT1 cells mediate gas exchange, whereas AT2 cells act as progenitor cells to repair injured alveoli. Lung microvascular endothelial cells (LMVECs) play a crucial but still poorly understood role in regulating alveolar repair. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107828DOI Listing

Feature sensitivity criterion-based sampling strategy from the Optimization based on Phylogram Analysis (Fs-OPA) and Cox regression applied to mental disorder datasets.

PLoS One 2020 1;15(7):e0235147. Epub 2020 Jul 1.

Department of Bioengineering, Universidade de Sao Paulo Escola de Engenharia de Sao Carlos, Sao Carlos, Sao Paulo, Brazil.

Digital datasets in several health care facilities, as hospitals and prehospital services, accumulated data from thousands of patients for more than a decade. In general, there is no local team with enough experts with the required different skills capable of analyzing them in entirety. The integration of those abilities usually demands a relatively long-period and is cost. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235147PLOS

Cell-Derived Exosome Therapy: A Novel Approach to Treat Post-traumatic Brain Injury Mediated Neural Injury.

ACS Chem Neurosci 2020 Jul 1. Epub 2020 Jul 1.

Department of Bioscience & Bioengineering, Indian Institute of Technology Jodhpur, NH 65, Surpura Bypass Road, Karwar, Rajasthan 342037, India.

Traumatic brain injury (TBI) causes serious neuronal injury that often leads to death. To date there is no clinically successful treatment strategy that has been reported which offers repair of the brain injury or neural injury. Significant attempts have been made to develop effective therapies for TBI, and one of the most promising approaches is a stem cell based therapeutic approach with mesenchymal stem cells (MSCs). Read More

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http://dx.doi.org/10.1021/acschemneuro.0c00368DOI Listing

Effect of atmospheric cold plasma treatment on antioxidant activities and reactive oxygen species production in postharvest blueberries during storage.

J Sci Food Agric 2020 Jul 1. Epub 2020 Jul 1.

College of Life Science, Dalian Minzu University, Dalian, 116600, China.

Background: Blueberry is universally acknowledged as a kind of berry rich in antioxidants. Cold plasma, an emerging non-thermal treatment technology, has been proved to be able to maintain or improve the antioxidant level while inactivating the microorganisms on the surface of fruits and vegetables. Postharvest blueberries were treated with atmospheric cold plasma (ACP; 12 kV, 5 kHz) for 0 s (Control), 30 s (ACP-30), 60 s (ACP-60), and 90 s (ACP-90) in this study, and the effects of ACP on the antimicrobial properties, antioxidant activities, and reactive oxygen species (ROS) production were investigated during storage at 4 ± 1°C for 40 days. Read More

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http://dx.doi.org/10.1002/jsfa.10611DOI Listing

Cu-Catalyzed tandem N-arylation of phthalhydrazides with cyclic iodoniums to yield dihydrobenzo[c]cinnolines.

Org Biomol Chem 2020 Jul;18(25):4824-4830

Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Function Materia, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, P. R. China.

Dihydrocinnolines have significant pharmacological properties. Herein, we investigate a Cu-catalyzed tandem N-arylation reaction of phthalhydrazides with cyclic iodonium salts to construct dihydrobenzo[c]cinnoline derivatives. Various iodonium salts, such as symmetrical, unsymmetrical, aryl-aryl, and aryl-heteroaryl ones, could react with phthalhydrazides smoothly and give the title products in moderate to high yields. Read More

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http://dx.doi.org/10.1039/d0ob00894jDOI Listing