250,099 results match your criteria Bioengineering Basel Switzerland[Journal]


Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.

Cytokine 2019 Apr 16;120:28-40. Epub 2019 Apr 16.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. Electronic address:

Viperin is an interferon-inducible protein that helps in protecting mammals against various virus infections. Viperin is a highly conserved member of the interferon-stimulated genes (ISG) family in many species. Viperin has been shown to play a pivotal role in the innate immunity of chicken; however, its role has not been explored in its antiviral potential. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.007DOI Listing

Independent component analysis based algorithms for high-density electromyogram decomposition: Experimental evaluation of upper extremity muscles.

Comput Biol Med 2019 Mar 13;108:42-48. Epub 2019 Mar 13.

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, United States. Electronic address:

Motor unit firing activities can provide critical information regarding neural control of skeletal muscles. Extracting motor unit activities reliably from surface electromyogram (EMG) is still a challenge in signal processing. We quantified the performance of three different independent component analysis (ICA)-based decomposition algorithms (Infomax, FastICA and RobustICA) on high-density EMG signals, obtained from arm muscles (biceps brachii and extensor digitorum communis) at different contraction levels. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193008
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.009DOI Listing
March 2019
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Design of porous titanium scaffold for complete mandibular reconstruction: The influence of pore architecture parameters.

Comput Biol Med 2019 Mar 12;108:31-41. Epub 2019 Mar 12.

Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, 721 302, West Bengal, India. Electronic address:

Patients having a medical history of oral cancer, infectious diseases or trauma are often advised surgical intervention with customized complete mandibular constructs (CMC) made of Titanium (Ti) scaffolds. A numerical framework based on a homogenization technique was developed to investigate the influence of pore architecture parameters on homogenized orthotropic material properties of the scaffolds. A comparative 3D Finite Element (FE) analysis of six CMC models, having homogenized orthotropic material properties, under a mastication cycle, was undertaken to pre-clinically determine the optimal CMC for a patient. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193007
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.004DOI Listing
March 2019
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Automated detection of sleep apnea using sparse residual entropy features with various dictionaries extracted from heart rate and EDR signals.

Comput Biol Med 2019 Mar 26;108:20-30. Epub 2019 Mar 26.

Department of Electronic & Computer Engineering, Ngee Ann Polytechnic, Singapore; Department of Biomedical Engineering, School of Science and Technology, SIM University, Singapore; Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Sleep is a prominent physiological activity in our daily life. Sleep apnea is the category of sleep disorder during which the breathing of the person diminishes causing the alternation in the upper airway resistance. The electrocardiogram derived respiration (EDR) and heart rate (RR-time-series) signals are normally used for the detection of sleep apnea as these two signals capture cardio-pulmonary activity information. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193008
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.016DOI Listing
March 2019
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Development of an innovative technology to segment luminal borders of intravascular ultrasound image sequences in a fully automated manner.

Comput Biol Med 2019 Mar 14;108:111-121. Epub 2019 Mar 14.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia; School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Australia.

Although intravascular ultrasound (IVUS) is the commonest intravascular imaging modality, it still is inefficient for clinical use as it requires laborious manual analysis. This study demonstrates the feasibility of a near real-time fully automated technology for accurate identification, detection, and quantification of luminal borders in intravascular images. This technology uses a combination of the novel approaches of a self-tuning engine, dynamic and static masking systems, radar-wise scan, and contour correction cycle method. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.008DOI Listing
March 2019
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Neuroprotective effect of Dictyopteris divaricata extract-capped gold nanoparticles against oxygen and glucose deprivation/reoxygenation.

Colloids Surf B Biointerfaces 2019 Mar 29;179:421-428. Epub 2019 Mar 29.

Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea; Department of Laboratory Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea.

Combination therapy remains a promising approach to ameliorate cerebral ischemia injury. Nevertheless, the primary mechanism of the neuroprotective properties of Dictyopteris divaricata extract-capped gold nanoparticles (DD-GNPs) is not completely understood. DD-GNPs displayed maximum absorption at 525 nm and a diameter of 62. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.066DOI Listing

Gut microbiota: An underestimated and unintended recipient for pesticide-induced toxicity.

Chemosphere 2019 Apr 13;227:425-434. Epub 2019 Apr 13.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:

Pesticide pollution residues have become increasingly common health hazards over the last several decades because of the wide use of pesticides. The gastrointestinal tract is the first physical and biological barrier to contaminated food and is therefore the first exposure site. Interestingly, a number of studies have shown that the gut microbiota plays a key role in the toxicity of pesticides and has a profound relationship with environmental animal and human health. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193074
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.088DOI Listing
April 2019
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Redaction of false high frequency oscillations due to muscle artifact improves specificity to epileptic tissue.

Clin Neurophysiol 2019 Apr 11;130(6):976-985. Epub 2019 Apr 11.

Department of Neurology, University of Michigan, USA; Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, USA. Electronic address:

Objective: High Frequency Oscillations (HFOs) are a promising biomarker of epilepsy. HFOs are typically acquired on intracranial electrodes, but contamination from muscle artifacts is still problematic in HFO analysis. This paper evaluates the effect of myogenic artifacts on intracranial HFO detection and how to remove them. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457193012
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http://dx.doi.org/10.1016/j.clinph.2019.03.028DOI Listing
April 2019
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A comprehensive assessment of stream fragmentation in Great Britain.

Sci Total Environ 2019 Apr 10;673:756-762. Epub 2019 Apr 10.

Department of Biosciences, College of Science, Swansea University, Swansea SA2 8PP, UK.

Artificial barriers are one of the main threats to river ecosystems, resulting in habitat fragmentation and loss of connectivity. Yet, the abundance and distribution of most artificial barriers, excluding high-head dams, is poorly documented. We provide a comprehensive assessment of the distribution and typology of artificial barriers in Great Britain, and estimate for the first time the extent of river fragmentation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193165
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.125DOI Listing
April 2019
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Fourier transform infrared spectroscopy research on subchondral bone in osteoarthritis.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 11;218:243-247. Epub 2019 Apr 11.

Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China. Electronic address:

Osteoarthritis (OA) is not only related to the degradation of articular cartilage, but also possibly to the changes of subchondral bone. The purpose of this study was to assess whether specific differences could be resolved from bone composition, as also contributed to OA. These differences were assessed by using Fourier transform infrared spectroscopy (FTIRS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193039
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http://dx.doi.org/10.1016/j.saa.2019.04.020DOI Listing
April 2019
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The nucleus feels the force, LINCed in or not!

Curr Opin Cell Biol 2019 Apr 16;58:114-119. Epub 2019 Apr 16.

Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA 94720, United States; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States. Electronic address:

Mechanical signals affect many aspects of biological processes. Physical forces from the extracellular microenvironment are ultimately transmitted to the nucleus and elicit a response that result in the deformation and remodeling of the nucleus. Recent studies have shown that nuclear deformation has several consequences such as reorganization of chromatin, changes in gene expression, and nuclear envelope rupture. Read More

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http://dx.doi.org/10.1016/j.ceb.2019.02.012DOI Listing

Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.

Pharmacol Res 2019 Apr 16. Epub 2019 Apr 16.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB) Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

In spite of billions of dollars expended on cancer research every year, the incidence rate and the mortality rate due to this widespread disease has increased drastically over the last few decades. Recent reports from the World Health Organization advocate that overall global cancer burden and deaths due to cancer are expected to double by the next decade. Synthetic drugs developed as chemotherapeutics have repeatedly shown adverse side effects and development of chemoresistance. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.04.004DOI Listing
April 2019
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CD30 Aptamer-functionalized PEG-PLGA nanoparticles for the superior delivery of doxorubicin to anaplastic large cell lymphoma cells.

Int J Pharm 2019 Apr 16. Epub 2019 Apr 16.

School of Biological Science and Engineering, South China University of Technology, Guangzhou 510640, China; Wenzhou Institute of Biomaterials and Engineering, CNITECH, Chinese Academy of Sciences, Wenzhou, Zhejiang Province, 325001, PR China. Electronic address:

Nanoparticles (NPs) conjugated with aptamers have been extensively in recent years, which can efficiently target cancer cells that improve the therapeutic effect. Aptamers (Apt) are small oligonucleotide molecule ligands have specific high-affinity. In this work, we developed a PEG-PLGA nanoparticles (NPs) encapsulated with doxorubicin. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.013DOI Listing

Multilayer nanoscale functionalisation to treat disorders and enhance regeneration of bone tissue.

Nanomedicine 2019 Apr 16. Epub 2019 Apr 16.

School of Engineering, Newcastle University, Claremont Road, Newcastle upon Tyne NE1 7RU, United Kingdom. Electronic address:

The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Read More

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http://dx.doi.org/10.1016/j.nano.2019.03.009DOI Listing

Chitosan and gelatin-based electrospun fibers for bone tissue engineering.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, India. Electronic address:

Fractures and injuries pertaining to bone tissue usually take prolonged periods for its natural healing. To overcome this problem, the field of bone tissue engineering (BTE) has acquired an efficient designing mechanism that incorporates cells, biomaterials and the corresponding growth factors to promote both osteogenesis as well as mineralization of the bone. Amidst the various techniques available for scaffold creation, electrospinning is considered superior as it paves the way for the creation of nanostructured scaffolds using biopolymers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193161
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.115DOI Listing
April 2019
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Nanocrystalline cellulose: Preparation, physicochemical properties, and applications in drug delivery systems.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Cancer is the leading cause of death all over the world and chemotherapy is an important approach to fight cancer, however, there are many obstacles against successful cancer chemotherapy such as development of multidrug resistance, poor solubility of chemotherapeutic agents and adverse side effects to healthy tissues. An important strategy to overcome these obstacles, is the use of nanotechnology. In recent years, natural polymers such as cellulose and its nanoform structure, nanocrystalline cellulose (NCC), have attracted the interest of researchers in the field of nanotechnology and specially drug delivery systems, due to biocompatibility and biodegradability of NCC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193169
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.117DOI Listing
April 2019
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Two-component cross-linkable gels for fabrication of solid oral dosage forms.

J Control Release 2019 Apr 16. Epub 2019 Apr 16.

Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel; Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa 3200003, Israel.

Current three-dimensional (3D) printing techniques involve the solidification of the injected materials by means of UV irradiation, evaporation of organic solvents, or harsh heating and cooling processes. These methods limit the printing of many sensitive bio-active molecules such as proteins. We describe a novel 3D printing technique based on two complementary liquid copolymers, PEG-PCL-SC and PEG-PCL-NH, that are injected in a coordinated fashion and react with each other to form a pre-designed 3D pill. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193022
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http://dx.doi.org/10.1016/j.jconrel.2019.04.021DOI Listing
April 2019
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Tissue engineered models of healthy and malignant human bone marrow.

Adv Drug Deliv Rev 2019 Apr 16. Epub 2019 Apr 16.

Columbia University, New York, USA. Electronic address:

Tissue engineering is becoming increasingly successful in providing in vitro models of human tissues that can be used for ex vivo recapitulation of functional tissues as well as predictive testing of drug efficacy and safety. From simple tissue models to microphysiological platforms comprising multiple tissue types connected by vascular perfusion, these "tissues on a chip" are emerging as a fast track application for tissue engineering, with great potential for modeling diseases and supporting the development of new drugs and therapeutic targets. We focus here on tissue engineering of the hematopoietic stem and progenitor cell compartment and the malignancies that develop in the human bone and bone marrow. Read More

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http://dx.doi.org/10.1016/j.addr.2019.04.003DOI Listing

Motor cortex metabolite alterations in Amyotrophic Lateral Sclerosis assessed in vivo using edited and non-edited magnetic resonance spectroscopy.

Brain Res 2019 Apr 16. Epub 2019 Apr 16.

Biomedical MRI unit/ MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. Electronic address:

Previous MRI and proton spectroscopy (H-MRS) studies have revealed impaired neuronal integrity and altered neurometabolite concentrations in the motor cortex of patients with amyotrophic lateral sclerosis (ALS). Here, we aim to use MRI with conventional and novel MRS sequences to further investigate neurometabolic changes in the motor cortex of ALS patients and their relation to clinical parameters. We utilized the novel HERMES (Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy) MRS sequence to simultaneously quantify the inhibitory neurotransmitter GABA and antioxidant glutathione in ALS patients (n=7) and healthy controls (n=7). Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.018DOI Listing

The Least Mating Pathway: Synthetically Refactoring a Familiar Signaling System for New Applications.

Cell 2019 Apr;177(3):521-523

Department of Bioengineering, Rice University, Houston, TX 77030, USA; Department of Biosciences, Rice University, Houston, TX 77030, USA. Electronic address:

Synthetic refactoring makes naturally occurring regulatory systems more amenable to manipulation by removing or recoding their natural genetic complexity. Shaw et al. apply this technique to the yeast mating response pathway, creating a simplified, highly engineerable signaling module that can be used to construct precisely optimized, application-specific GPCR biosensors. Read More

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http://dx.doi.org/10.1016/j.cell.2019.04.003DOI Listing

Fatigue resistance of yttria-stabilized tetragonal zirconia polycrystal clasps for removable partial dentures.

Eur J Oral Sci 2019 Apr 19. Epub 2019 Apr 19.

Department of Anatomy and Functional Restorations, Integrated Health Sciences, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan.

With the rapid development of computer-aided design/computer-aided manufacturing (CAD/CAM) systems, the application of zirconia in removable partial dentures is expected to expand. Clasps composed of zirconia should improve esthetics without inducing the risk of metal allergy. The aim of this study was to examine the fatigue resistance of yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) clasps for removable partial dentures. Read More

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http://dx.doi.org/10.1111/eos.12615DOI Listing

Impact of Intracranial Aneurysm Morphology and Rupture Status on the Particle Residence Time.

J Neuroimaging 2019 Apr 19. Epub 2019 Apr 19.

Department of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Background And Purpose: Aneurysm hemodynamics play an important role in aneurysm growth and subsequent rupture. Within the available hemodynamic characteristics, particle residence time (PRT) is relatively unexplored. However, some studies have shown that PRT is related to thrombus formation and inflammation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12618
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http://dx.doi.org/10.1111/jon.12618DOI Listing
April 2019
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A coarse-grained red blood cell membrane model to study stomatocyte-discocyte-echinocyte morphologies.

PLoS One 2019 19;14(4):e0215447. Epub 2019 Apr 19.

School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.

An improved red blood cell (RBC) membrane model is developed based on the bilayer coupling model (BCM) to accurately predict the complete sequence of stomatocyte-discocyte-echinocyte (SDE) transformation of a RBC. The coarse-grained (CG)-RBC membrane model is proposed to predict the minimum energy configuration of the RBC from the competition between lipid-bilayer bending resistance and cytoskeletal shear resistance under given reference constraints. In addition to the conventional membrane surface area, cell volume and bilayer-leaflet-area-difference constraints, a new constraint: total-membrane-curvature is proposed in the model to better predict RBC shapes in agreement with experimental observations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215447PLOS

CancerInSilico: An R/Bioconductor package for combining mathematical and statistical modeling to simulate time course bulk and single cell gene expression data in cancer.

PLoS Comput Biol 2019 Apr 19;14(4):e1006935. Epub 2019 Apr 19.

Department of Oncology, Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD United States of America.

Bioinformatics techniques to analyze time course bulk and single cell omics data are advancing. The absence of a known ground truth of the dynamics of molecular changes challenges benchmarking their performance on real data. Realistic simulated time-course datasets are essential to assess the performance of time course bioinformatics algorithms. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006935DOI Listing

Thirteen-Week Oral Toxicity Evaluation of Erinacine AEnriched Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Mycelia in Sprague-Dawley Rats.

Int J Med Mushrooms 2019 ;21(4):401-411

College of Veterinary Medicine, National Chung Hsing University, Taichung City, Taiwan.

Recently, erinacine A-enriched Hericium erinaceus (EAHE) mycelia have demonstrated therapeutic efficacy in animal models of neurodegenerative disease, including Alzheimer and Parkinson disease. Despite promising results from animal models, there have been no reports on its toxicity after long-term consumption. Hence, the present study was designed to evaluate the safety of EAHE mycelia through a 13-week subchronic rodent feeding study. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030320DOI Listing
January 2019

Optimization of Cultivation Conditions of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) for the Highest Antioxidant Activity and Antioxidant Content.

Int J Med Mushrooms 2019 ;21(4):353-366

Institute of Food Biotechnology and College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou, Guangdong, China.

Ganoderma lucidum is a famous medicinal mushroom that is rich in antioxidants. The content of antioxidant components of grains can be effectively improved by G. lucidum as the fermenting strain. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030338DOI Listing
January 2019
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Comparison of Chemical Compositions, Bioactive Ingredients, and In Vitro Antitumor Activity of Four Products of Cordyceps (Ascomycetes) Strains from China.

Int J Med Mushrooms 2019 ;21(4):331-342

Department of Bioengineering, College of Life Sciences, Huaibei Normal University, Huaibei, Anhui, China.

The chemical compositions, bioactive ingredients, and in vitro antitumor activity were analyzed using water extracts from the dried fermented mycelia of Cephalosporium sinensis (C1), Paecilomyces hepiali (C2), Cordyceps cicadae (C3), as well as the dried fruiting bodies of C. militaris (C4). Total amino acid content was highest in C3, compared with C1, C2, C4, and natural C. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030329DOI Listing
January 2019

Activated red mud as a permeable reactive barrier material for fluoride removal from groundwater: Parameter optimization and physico-chemical characterization.

Environ Technol 2019 Apr 19:1-39. Epub 2019 Apr 19.

a Department of Chemical Engineering , GMR Institute of Technology , Rajam 532 127 , Srikakulam , India.

The main aim of this work is to test the performance of red mud as a permeable reactive barrier (PRB) material for fluoride removal from water. Batch experiments were carried out to optimize the fluoride removal efficiency (RE) of activated red mud (ARM) based on four selected parameters, namely, the initial fluoride concentration (3-40 mg/L), adsorbent dose (0.5-5 g/L), pH (3. Read More

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http://dx.doi.org/10.1080/09593330.2019.1609591DOI Listing

Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model.

FASEB J 2019 Apr 19:fj201802347RRR. Epub 2019 Apr 19.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Aromatase inhibitors are the preferred treatment for certain women with estrogen receptor (ER)-positive breast cancer, but evidence suggests that women with obesity experience aromatase inhibitor resistance at higher rates. To compare how stromal cells derived from women who are lean or obese influence response to the aromatase inhibitor (anastrazole), we incorporated patient-derived stroma in a previously characterized MCF7-derived duct model. Coculture with adipose stromal cells enabled the metabolism of testosterone (T) to E, which induced estrogen response element activity, epithelial proliferation, and hyperplasia in MCF7 cells. Read More

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http://dx.doi.org/10.1096/fj.201802347RRRDOI Listing

Sorafenib Induces Pyroptosis in Macrophages and Triggers NK Cell-Mediated Cytotoxicity Against Hepatocellular Carcinoma.

Hepatology 2019 Apr 19. Epub 2019 Apr 19.

Roche Innovation Center Munich, Roche Pharma Research and Early Development, Nonnenwald 2, 82377, Penzberg, Germany.

Antiangiogenic and cytotoxic effects are referred as the principle mechanisms of action of sorafenib, a multi-target kinase inhibitor approved for the treatment of hepatocellular carcinoma (HCC). Here we report, that sorafenib also acts via direct immune-modulation indispensable for its anti-tumor activity. In vivo cell depletion experiments in two orthotopic HCC mouse models as well as in vitro analysis identified macrophages (MΦ) as the key mediators of the anti-tumoral effect and demonstrate a strong interdependency of MΦ and natural killer (NK) cells for efficient tumor cell killing. Read More

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http://dx.doi.org/10.1002/hep.30666DOI Listing

Multi-subtype classification model for non-small cell lung cancer based on radiomics: SLS model.

Med Phys 2019 Apr 19. Epub 2019 Apr 19.

Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China.

Purpose: Histological subtypes of non-small cell lung cancer (NSCLC) are crucial for systematic treatment decisions. However, the current studies which used non-invasive radiomic methods to classify NSCLC histology subtypes mainly focused on two main subtypes: squamous cell carcinoma (SCC) and adenocarcinoma (ADC), while multi-subtype classifications that included the other two subtypes of NSCLC: large cell carcinoma (LCC) and not otherwise specified (NOS), were very few in the previous studies. The aim of this work is to establish a multi-subtype classification model for the four main subtypes of NSCLC and improve the classification performance and generalization ability compared with previous studies. Read More

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http://dx.doi.org/10.1002/mp.13551DOI Listing

Effect of electrochemotherapy with betulinic acid or cisplatin on regulation of heat shock proteins in metastatic human carcinoma cells in vitro.

Oncol Rep 2019 Apr 8. Epub 2019 Apr 8.

Department of Molecular and Cellular Biology, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, 50‑556 Wroclaw, Poland.

Betulinic acid (BTA) is naturally occurring triterpene that has received interest as a novel therapeutic substance with cytotoxicity towards a number of cancer cell lines. Despite the wide spectrum of biological and pharmacological effects, its effect may be limited its lipophobic properties. Therefore, strategies to improve the access of BTA to the cells are required to enhance the anticancer effects. Read More

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http://dx.doi.org/10.3892/or.2019.7103DOI Listing

Association of Peritumoral Radiomics With Tumor Biology and Pathologic Response to Preoperative Targeted Therapy for HER2 (ERBB2)-Positive Breast Cancer.

JAMA Netw Open 2019 Apr 5;2(4):e192561. Epub 2019 Apr 5.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

Importance: There has been significant recent interest in understanding the utility of quantitative imaging to delineate breast cancer intrinsic biological factors and therapeutic response. No clinically accepted biomarkers are as yet available for estimation of response to human epidermal growth factor receptor 2 (currently known as ERBB2, but referred to as HER2 in this study)-targeted therapy in breast cancer.

Objective: To determine whether imaging signatures on clinical breast magnetic resonance imaging (MRI) could noninvasively characterize HER2-positive tumor biological factors and estimate response to HER2-targeted neoadjuvant therapy. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2561DOI Listing

Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates.

Org Lett 2019 Apr 19. Epub 2019 Apr 19.

Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering , Tokyo Medical and Dental University (TMDU) , 2-3-10 Kanda-Surugadai , Chiyoda-ku, Tokyo 101-0062 , Japan.

A mild and odorless copper-catalyzed thiolation of terminal alkynes with thiosulfonates is described. The broad substrate scope provides convenient access to a wide variety of sulfur-containing heterocycles. In particular, divergent benzoheteroles are efficiently prepared in a simple manner by thiolation of ethynylbenzenes bearing ortho-nucleophilic functional groups followed by iodocyclization. Read More

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http://pubs.acs.org/doi/10.1021/acs.orglett.9b00875
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http://dx.doi.org/10.1021/acs.orglett.9b00875DOI Listing
April 2019
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Benefits and hazards of electromagnetic waves, telecommunication, physical and biomedical: a review.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3121-3128

Department of Information Engineering, Electronics and Telecommunications, Sapienza University of Rome, Rome, Italy.

Objective: The aim of this paper is to review the current literature on electromagnetic radiation (EMR): physical, biophysical, and telecommunication. The widespread application of EMR in modern technologies requires telecommunication and healthcare professionals to possess some knowledge of its physical and biological properties. In this review article, we will discuss biophysical principles of EMR, its interactions with living organisms and its application in clinical practices. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17596DOI Listing
April 2019
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Evaluation of In Vitro Hemolysis and Platelet Activation of a Newly Developed MagLev LVAD and Two Clinically Used LVADs with Human Blood.

Artif Organs 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

In-vitro hemolysis testing remains one of the most important performance measures to judge the hemocompatibility of a left ventricular assist device (LVAD). Clinically relevant operating conditions and appropriate testing blood are essential to infer in-vitro data for potential clinical use. This in-vitro study was carried out to evaluate and compare the hemolytic performance of a newly developed magnetically levitated (maglev) LVAD (CH-VAD) with two clinically used LVADs (HVAD and HeartMate II) using fresh human blood. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/aor.13471
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http://dx.doi.org/10.1111/aor.13471DOI Listing
April 2019
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Old is gold? Retrospective evaluation of efficacy and safety of topical psoralen-UVA phototherapy for palmoplantar psoriasis and dermatitis.

Br J Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Photomedicine Institute, Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.

Over the last decade new systemic drugs (e.g. biologics, apremilast, alitretinoin) have diversified the options for treating palmoplantar dermatoses such as psoriasis and dermatitis. Read More

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http://dx.doi.org/10.1111/bjd.18012DOI Listing

Characterization of earthworm α-amylases for dietary supplement development and biomass utilization.

Environ Sci Pollut Res Int 2019 Apr 18. Epub 2019 Apr 18.

Department of Bioengineering, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka, Niigata, 940-2188, Japan.

Earthworms are useful soil-decomposing animals that possess various saccharification enzymes such as cellulases and amylases. Earthworms have also been traditionally used as antipyretic agents and medicines for preventing thrombotic diseases such as brain infarction. We previously developed a novel earthworm dietary supplement with fibrinolytic, cellulase, and amylase activities using high-pressure technology. Read More

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http://dx.doi.org/10.1007/s11356-019-05133-xDOI Listing

Mimivirus encodes a multifunctional primase with DNA/RNA polymerase, terminal transferase and translesion synthesis activities.

Nucleic Acids Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra 400076, India.

Acanthamoeba polyphaga mimivirus is an amoeba-infecting giant virus with over 1000 genes including several involved in DNA replication and repair. Here, we report the biochemical characterization of gene product 577 (gp577), a hypothetical protein (product of L537 gene) encoded by mimivirus. Sequence analysis and phylogeny suggested gp577 to be a primase-polymerase (PrimPol)-the first PrimPol to be identified in a nucleocytoplasmic large DNA virus (NCLDV). Read More

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http://dx.doi.org/10.1093/nar/gkz236DOI Listing

Transition From Phasic to Tonic Contractility in Airway Smooth Muscle After Birth: An Experimental and Computational Modeling Study.

J Eng Sci Med Diagn Ther 2019 Feb 8;2(1). Epub 2019 Feb 8.

School of Human Sciences, The University of Western Australia, Crawley 6009, Western Australia, Australia.

Fetal airway smooth muscle (ASM) exhibits phasic contractile behavior, which transitions to a more sustained "tonic" contraction after birth. The timing and underlying mechanisms of ASM transition from a phasic to a tonic contractile phenotype are yet to be established. We characterized phasic ASM contraction in preterm (128 day gestation), term (~150 day gestation), 1-4 month, 1 yr, and adult sheep (5yr). Read More

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http://dx.doi.org/10.1115/1.4042312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467295PMC
February 2019

Critical role of spectrin in hearing development and deafness.

Sci Adv 2019 Apr 17;5(4):eaav7803. Epub 2019 Apr 17.

iHuman Institute, ShanghaiTech University, Shanghai, China.

Inner ear hair cells (HCs) detect sound through the deflection of mechanosensory stereocilia. Stereocilia are inserted into the cuticular plate of HCs by parallel actin rootlets, where they convert sound-induced mechanical vibrations into electrical signals. The molecules that support these rootlets and enable them to withstand constant mechanical stresses underpin our ability to hear. Read More

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aav
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http://dx.doi.org/10.1126/sciadv.aav7803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469942PMC
April 2019
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Imaging localized neuronal activity at fast time scales through biomechanics.

Sci Adv 2019 Apr 17;5(4):eaav3816. Epub 2019 Apr 17.

School of Biomedical Engineering and Imaging Sciences, Kings College London, London, UK.

Mapping neuronal activity noninvasively is a key requirement for in vivo human neuroscience. Traditional functional magnetic resonance (MR) imaging, with a temporal response of seconds, cannot measure high-level cognitive processes evolving in tens of milliseconds. To advance neuroscience, imaging of fast neuronal processes is required. Read More

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http://dx.doi.org/10.1126/sciadv.aav3816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469937PMC

Verbal Fluency Is Affected by Altered Brain Lateralization in Adults Who Were Born Very Preterm.

eNeuro 2019 Mar-Apr;6(2). Epub 2019 Apr 15.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom SE5 8AF.

Language difficulties have been reported in children and adolescents who were born very preterm (<32 weeks' gestation) and associated with an atypical lateralization of language processing, i.e., increased right-hemispheric engagement. Read More

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http://dx.doi.org/10.1523/ENEURO.0274-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469882PMC

Distance canonical correlation analysis with application to an imaging-genetic study.

J Med Imaging (Bellingham) 2019 Apr 11;6(2):026501. Epub 2019 Apr 11.

Tulane University, Department of Biomedical Engineering, New Orleans, Louisiana, United States.

Distance correlation is a measure that can detect both linear and nonlinear associations. However, applying distance correlation to imaging genetic studies often needs multiple testing correction due to the large number of multiple inferences. As a result, the sensitivity of its detection may be low. Read More

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http://dx.doi.org/10.1117/1.JMI.6.2.026501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458489PMC
April 2019
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Tubing-Free Microfluidic Microtissue Culture System Featuring Gradual, -Like Substance Exposure Profiles.

Front Bioeng Biotechnol 2019 2;7:72. Epub 2019 Apr 2.

Bioengineering Laboratory, Department of Biosystems Science and Engineering, ETH Zürich, Zurich, Switzerland.

screening methods for compound efficacy and toxicity to date mostly include cell or tissue exposure to preset constant compound concentrations over a defined testing period. Such concentration profiles, however, do not represent realistic situations after substance uptake. Absorption, distribution, metabolism and excretion of administered substances in an organism or human body entail gradually changing pharmacokinetic concentration profiles. Read More

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http://dx.doi.org/10.3389/fbioe.2019.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454105PMC

Effects of Oxygen Concentration and Culture Time on Porcine Nucleus Pulposus Cell Metabolism: An Study.

Front Bioeng Biotechnol 2019 2;7:64. Epub 2019 Apr 2.

Orthopaedic Biomechanics Laboratory, Department of Biomedical Engineering, University of Miami, Coral Gables, FL, United States.

Low back pain is a common ailment that affects millions of individuals each year and is linked to degeneration of the intervertebral discs in the spine. Intervertebral disc degeneration is known to result from an imbalance in anabolic and catabolic activity by disc cells. Due to the avascular nature of the intervertebral disc, oxygen deficiency may occur in the central nucleus pulposus (NP). Read More

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http://dx.doi.org/10.3389/fbioe.2019.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454860PMC

Methods for Segmentation and Classification of Digital Microscopy Tissue Images.

Front Bioeng Biotechnol 2019 2;7:53. Epub 2019 Apr 2.

Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

High-resolution microscopy images of tissue specimens provide detailed information about the morphology of normal and diseased tissue. Image analysis of tissue morphology can help cancer researchers develop a better understanding of cancer biology. Segmentation of nuclei and classification of tissue images are two common tasks in tissue image analysis. Read More

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http://dx.doi.org/10.3389/fbioe.2019.00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454006PMC

Editorial: Metastasis: From Cell Adhesion and Beyond.

Front Oncol 2019 2;9:214. Epub 2019 Apr 2.

Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus.

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http://dx.doi.org/10.3389/fonc.2019.00214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454140PMC

CACNA2D3 Enhances the Chemosensitivity of Esophageal Squamous Cell Carcinoma to Cisplatin via Inducing Ca-Mediated Apoptosis and Suppressing PI3K/Akt Pathways.

Front Oncol 2019 2;9:185. Epub 2019 Apr 2.

Department of Cell Biology, Institute of Biomedicine, Jinan University, Guangzhou, China.

Resistance to platinum-based combination chemotherapy is the main cause of poor prognosis in patients with advanced esophageal squamous cell carcinoma (ESCC). Previously, we showed that CACNA2D3 (voltage-dependent subunit alpha 2 delta 3 of a calcium channel complex) was significantly downregulated and functioned as a tumor suppressor in ESCC, but its role in the chemosensitivity of ESCC to cisplatin remained unknown. Here, we found that the expression of CACNA2D3 was significantly associated with poor platinum response in ESCC patients from the Gene Expression Omnibus database. Read More

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http://dx.doi.org/10.3389/fonc.2019.00185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454090PMC

Experimental Implementation of Automatic Control of Posture-Dependent Stimulation in an Implanted Standing Neuroprosthesis.

Appl Bionics Biomech 2019 14;2019:2639271. Epub 2019 Mar 14.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland 44106, USA.

Knowledge of the upper extremity (UE) effort exerted under real-world conditions is important for understanding how persons with motor or sensory disorders perform the postural shifts necessary to complete many activities of daily living while standing. To this end, a feedback controller, named the "Posture Follower Controller", was developed to aid in task-dependent posture shifting by individuals with spinal cord injury standing with functional neuromuscular stimulation. In this experimental feasibility study, the controller modulated activation to the paralyzed lower extremity muscles as a function of the position of overall center of pressure (CoP), which was prescribed to move in a straight line in forward and diagonal directions. Read More

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http://dx.doi.org/10.1155/2019/2639271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437738PMC