537,653 results match your criteria Bioenergetics : open access[Journal]


Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: roles of FGF21 and bile acids.

J Nutr Biochem 2020 Apr 30;83:108403. Epub 2020 Apr 30.

Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China; Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA. Electronic address:

Glycolipid metabolism disorder is one of the causes of type 2 diabetes (T2D). Alternate-day fasting (ADF) is an effective dietary intervention to counteract T2D. The present study is aimed to determine the underlying mechanisms of the benefits of ADF metabolic on diabetes-induced glycolipid metabolism disorders in db/db mice. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108403DOI Listing

Alzheimer's and Parkinson's Brain Tissues Have Reduced Expression of Genes for mtDNA OXPHOS Proteins, Mitobiogenesis Regulator PGC-1α Protein and mtRNA Stabilizing Protein LRPPRC (LRP130).

Mitochondrion 2020 Jun 1. Epub 2020 Jun 1.

Neurodegeneration Therapeutics, Inc., Charlottesville, VA 22901, United States.

We used RNA sequencing (RNA-seq) to quantitate gene expression in total RNA extracts of vulnerable brain tissues from Alzheimer's disease (AD, frontal cortical ribbon) and Parkinson's disease (PD, ventral midbrain) subjects and phenotypically negative control subjects. Paired-end sequencing files were processed with HISAT2 aligner/Cufflinks quantitation against the hg38 human genome. We observed a significant decrease in gene expression of all mtDNA OXPHOS genes in AD and PD tissues. Read More

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http://dx.doi.org/10.1016/j.mito.2020.05.012DOI Listing

The emerging antioxidant paradigm of mesenchymal stem cell therapy.

Stem Cells Transl Med 2020 Jun 4. Epub 2020 Jun 4.

Institute for Health and Sport, Victoria University, Western Centre for Health, Research and Education, Sunshine Hospital, Melbourne, Victoria, Australia.

Mesenchymal stem cells (multipotent stromal cells; MSCs) have been under investigation for the treatment of diverse diseases, with many promising outcomes achieved in animal models and clinical trials. The biological activity of MSC therapies has not been fully resolved which is critical to rationalizing their use and developing strategies to enhance treatment efficacy. Different paradigms have been constructed to explain their mechanism of action including tissue regeneration, trophic/anti-inflammatory secretion, and immunomodulation. Read More

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http://dx.doi.org/10.1002/sctm.19-0446DOI Listing

Insights into the unique carboxylation reactions in the metabolism of propylene and acetone.

Biochem J 2020 Jun;477(11):2027-2038

Institute of Biological Chemistry, Washington State University, Pullman, WA 99164, U.S.A.

Alkenes and ketones are two classes of ubiquitous, toxic organic compounds in natural environments produced in several biological and anthropogenic processes. In spite of their toxicity, these compounds are utilized as primary carbon and energy sources or are generated as intermediate metabolites in the metabolism of other compounds by many diverse bacteria. The aerobic metabolism of some of the smallest and most volatile of these compounds (propylene, acetone, isopropanol) involves novel carboxylation reactions resulting in a common product acetoacetate. Read More

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http://dx.doi.org/10.1042/BCJ20200174DOI Listing

Comparative metagenomics reveals the microbial diversity and metabolic potentials in the sediments and surrounding seawaters of Qinhuangdao mariculture area.

PLoS One 2020 4;15(6):e0234128. Epub 2020 Jun 4.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, China.

Qinhuangdao coastal area is an important mariculture area in North China. Microbial communities play an important role in driving biogeochemical cycle and energy flow. It is necessary to identify the microbial communities and their functions in the coastal mariculture area of Qinhuangdao. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234128PLOS

Amyloid beta (1-42) downregulates adenosine-2b receptors in addition to mitochondrial impairment and cholinergic dysfunction in memory-sensitive mouse brain regions.

J Recept Signal Transduct Res 2020 Jun 4:1-10. Epub 2020 Jun 4.

Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, India.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment. Adenosinergic receptors are considered as a potential alternative in the management of several neurodegenerative disorders. However, there is no information available on the role of A2b receptor in the pathophysiology of AD. Read More

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http://dx.doi.org/10.1080/10799893.2020.1767136DOI Listing

Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish.

EMBO Rep 2020 Jun 4:e50287. Epub 2020 Jun 4.

Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.

The oxidative phosphorylation (OXPHOS) system is a dynamic system in which the respiratory complexes coexist with super-assembled quaternary structures called supercomplexes (SCs). The physiological role of SCs is still disputed. Here, we used zebrafish to study the relevance of respiratory SCs. Read More

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http://dx.doi.org/10.15252/embr.202050287DOI Listing

Metabolomics coupled with integrative pharmacology reveals the therapeutic effect of l-borneolum against cerebral ischaemia in rats.

J Pharm Pharmacol 2020 Jun 4. Epub 2020 Jun 4.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Objectives: This study aimed to investigate metabolic biomarker changes and related metabolic pathways before and after treatment with l-borneolum in cerebral ischaemic rats.

Methods: Rats were subjected to pMCAO surgery. The Zea-Longa scoring method was used to evaluate neurological deficits. Read More

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http://dx.doi.org/10.1111/jphp.13294DOI Listing

[Mechanism of Xuanfei Baidu Tang in treatment of COVID-19 based on network pharmacology].

Zhongguo Zhong Yao Za Zhi 2020 May;45(10):2249-2256

State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China.

The study aimed to investigate the multi-constituent, multi-target mechanism of Xuanfei Baidu Tang(XFBD) in the treatment of coronavirus disease 2019(COVID-19), through exploring the main ingredients and effective targets of XFBD, as well as analyzing the correlation between XFBD targets and COVID-19. The compounds of each herb in XFBD were collected from TCM-PTD, ETCM, TCMSP and SymMap database. Next, the information of meridian tropisms was collected from Chinese Pharmacopoeia(2015 edition), and the target information of the major constituents of XFBD were obtained from TCM-PTD, ETCM, TCMSP and TargetNet database. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200325.401DOI Listing

[Research progress of mitochondria as target of traditional Chinese medicines in treatment of heart failure].

Zhongguo Zhong Yao Za Zhi 2020 May;45(9):2082-2090

State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China Chinese Medicine New Drug Research and Development Center, Tianjin International Biomedical Research Institute Tianjin 300457, China.

As the final destination of various cardiovascular abnormalities, heart failure is one of the diseases with the highest morbidity and mortality in the world. Due to its complicated pathogenesis, people urgently need to find new targets and effective treatment. Imbalance in myocardial energy metabolism, an important molecular biological basis for heart failure, affects the contractile and diastolic functions of the heart. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200313.401DOI Listing

New findings on urinary prostate cancer metabolome through combined GC-MS and H NMR analytical platforms.

Metabolomics 2020 Jun 3;16(6):70. Epub 2020 Jun 3.

UCIBIO/REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.

Introduction: The inherent sensitivity of metabolomics allows the detection of subtle alterations in biological pathways, making it a powerful tool to study biomarkers and the mechanisms that underlie cancer.

Objectives: The purpose of this work was to characterize the urinary metabolic profile of prostate cancer (PCa) patients and cancer-free controls to obtain a holistic coverage of PCa metabolome.

Methods: Two groups of samples, a training set (n = 41 PCa and n = 42 controls) and an external validation set (n = 18 PCa and n = 18 controls) were analyzed using a dual analytical platform, namely gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance spectroscopy (H NMR). Read More

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http://dx.doi.org/10.1007/s11306-020-01691-1DOI Listing

Changes in energy system contributions to the Wingate anaerobic test in climbers after a high altitude expedition.

Eur J Appl Physiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Biomedical Sciences for Health, Università Degli Studi Di Milano, Via G. Colombo 71, 20133, Milan, Italy.

Purpose: The Wingate anaerobic test measures the maximum anaerobic capacity of the lower limbs. The energy sources of Wingate test are dominated by anaerobic metabolism (~ 80%). Chronic high altitude exposure induces adaptations on skeletal muscle function and metabolism. Read More

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http://dx.doi.org/10.1007/s00421-020-04392-8DOI Listing

Muscle cooling modulates tissue oxidative and biochemical responses but not energy metabolism during exercise.

Eur J Appl Physiol 2020 Jun 3. Epub 2020 Jun 3.

Laboratory of Environmental Exercise Physiology, School of Human Kinetics, Laurentian University, 935 Ramsey Lake Rd., Ben Avery Building, Sudbury, ON, P3E 2C6, Canada.

Purpose: This study investigated whether muscle cooling and its associated effects on skeletal muscle oxidative responses, blood gases, and hormonal concentrations influenced energy metabolism during cycling.

Methods: Twelve healthy participants (Males: seven; Females: five) performed two steady-state exercise sessions at 70% of ventilatory threshold on a cycle ergometer. Participants completed one session with pre-exercise leg cooling until muscle temperature (T) decreased by 6 °C (LCO), and a separate session without cooling (CON). Read More

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http://dx.doi.org/10.1007/s00421-020-04407-4DOI Listing

Anti-Lipolysis Induced by Insulin in Diverse Pathophysiologic Conditions of Adipose Tissue.

Diabetes Metab Syndr Obes 2020 11;13:1575-1585. Epub 2020 May 11.

Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangdong, People's Republic of China.

As an important energy reservoir, adipose tissue maintains lipid balance and regulates energy metabolism. When the body requires energy, adipocytes provide fatty acids to peripheral tissues through lipolysis. Insulin plays an important role in regulating normal fatty acid levels by inhibiting lipolysis. Read More

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http://dx.doi.org/10.2147/DMSO.S250699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227813PMC

Effect of Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women.

Clin Interv Aging 2020 13;15:663-671. Epub 2020 May 13.

Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, Gdansk, Poland.

Background: Excess iron accumulation in human tissue is associated with the diet, lack of exercise, or genetic factors. Iron accumulation increases the risk of acute myocardial infarction, diabetes, and cancer. On the other hand, exercise reduces the risk of several morbidities and influences iron metabolism. Read More

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http://dx.doi.org/10.2147/CIA.S252661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231752PMC

Creatine metabolism: energy homeostasis, immunity and cancer biology.

Nat Rev Endocrinol 2020 Jun 3. Epub 2020 Jun 3.

Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.

Perturbations in metabolic processes are associated with diseases such as obesity, type 2 diabetes mellitus, certain infections and some cancers. A resurgence of interest in creatine biology is developing, with new insights into a diverse set of regulatory functions for creatine. This resurgence is primarily driven by technological advances in genetic engineering and metabolism as well as by the realization that this metabolite has key roles in cells beyond the muscle and brain. Read More

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http://dx.doi.org/10.1038/s41574-020-0365-5DOI Listing

Biochemical profiles of rat primary cultured hepatocytes following treatment with rotenone, FCCP, or (+)-usnic acid.

J Toxicol Sci 2020 ;45(6):339-347

Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.

The metabolomic profiles of rat primary hepatocytes following treatment with rotenone, FCCP, or (+)-usnic acid were determined using liquid chromatography-mass spectrometry/mass spectrometry and gas chromatography-mass spectrometry. Significant and similar changes in the levels of 283 biochemical metabolites were associated with the three treatments compared with solvent control samples. Overall, the three treatments generated similar global biochemical profiles, with some minor differences associated with rotenone treatment. Read More

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http://dx.doi.org/10.2131/jts.45.339DOI Listing
January 2020

Retinoids in the visual cycle: Role of the retinal G protein-coupled receptor.

J Lipid Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, United States

Driven by the energy of a photon, the visual pigments in rod and cone photoreceptor cells isomerize 11-cis-retinal to the all-trans configuration. This photochemical reaction initiates the signal transduction pathway that eventually leads to the transmission of a visual signal to the brain and leaves the opsins insensitive to further light stimulation. For the eye to restore light sensitivity, opsins require recharging with 11-cis-retinal. Read More

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http://dx.doi.org/10.1194/jlr.TR120000850DOI Listing

Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO-induced inflammation in zebrafish by metabolomic and proteomic analyses.

J Neuroinflammation 2020 Jun 3;17(1):173. Epub 2020 Jun 3.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China.

Background: Inflammation is a general pathological phenomenon during severe disturbances to the homeostasis. Forsythiaside A (FA) and forsythiaside B (FB), isolated from the dried fruit of Forsythia suspensa (Thunb.) Vahl, are phenylethanoid compounds that show a significant anti-inflammatory effect. Read More

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http://dx.doi.org/10.1186/s12974-020-01855-9DOI Listing

Combined use of Diane-35 and metformin improves the ovulation in the PCOS rat model possibly via regulating glycolysis pathway.

Reprod Biol Endocrinol 2020 Jun 3;18(1):58. Epub 2020 Jun 3.

Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, 421001, China.

Background: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disease with unknown pathogenesis. However, the treatment of Diane-35 combined with metformin can improve the endocrine and ovulation of PCOS. In this study, we investigated the effects of Diane-35 combined with metformin (DM) treatment on ovulation and glucose metabolism in a PCOS rat model. Read More

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http://dx.doi.org/10.1186/s12958-020-00613-zDOI Listing

Regulators of glucose uptake in thyroid cancer cell lines.

Cell Commun Signal 2020 Jun 3;18(1):83. Epub 2020 Jun 3.

Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Thyroid cancer is the most common sort of endocrine-related cancer with more prevalent in women and elderly individuals which has quickly widespread expansion in worldwide over the recent decades. Common features of malignant thyroid cells are to have accelerated metabolism and increased glucose uptake to optimize their energy supply which provides a fundamental advantage for growth. In tumor cells the retaining of required energy charge for cell survival is imperative, indeed glucose transporters are enable of promoting of this task. Read More

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http://dx.doi.org/10.1186/s12964-020-00586-xDOI Listing

iTRAQ-based quantitative proteomics analysis of cantaloupe (Cucumis melo var. saccharinus) after cold storage.

BMC Genomics 2020 Jun 3;21(1):390. Epub 2020 Jun 3.

College of Food, Shihezi University, Xinjiang, 832000, China.

Background: Cantaloupe is susceptible to cold stress when it is stored at low temperatures, resulting in the loss of edible and commercial quality. To ascertain the molecular mechanisms of low temperatures resistance in cantaloupe, a cold-sensitive cultivar, Golden Empress-308 (GE) and a cold-tolerant cultivar, Jia Shi-310 (JS), were selected in parallel for iTRAQ quantitative proteomic analysis.

Results: The two kinds of commercial cultivars were exposed to a temperature of 0. Read More

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http://dx.doi.org/10.1186/s12864-020-06797-3DOI Listing

Systematic identification and comparative analysis of lysine succinylation between the green and white parts of chimeric leaves of Ananas comosus var. bracteatus.

BMC Genomics 2020 Jun 3;21(1):383. Epub 2020 Jun 3.

College of Landscape Architecture, Sichuan Agricultural University, Chengdu, China.

Background: Lysine succinylation, an important protein posttranslational modification (PTM), is widespread and conservative. The regulatory functions of succinylation in leaf color has been reported. The chimeric leaves of Ananas comosus var. Read More

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http://dx.doi.org/10.1186/s12864-020-6750-6DOI Listing

Flavin Adenine Dinucleotide Fluorescence as an Early Marker of Mitochondrial Impairment During Brain Hypoxia.

Int J Mol Sci 2020 Jun 1;21(11). Epub 2020 Jun 1.

Institute for Neurophysiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.

Multimodal continuous bedside monitoring is increasingly recognized as a promising option for early treatment stratification in patients at risk for ischemia during neurocritical care. Modalities used at present are, for example, oxygen availability and subdural electrocorticography. The assessment of mitochondrial function could be an interesting complement to these modalities. Read More

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http://dx.doi.org/10.3390/ijms21113977DOI Listing

The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome.

J Clin Med 2020 Jun 1;9(6). Epub 2020 Jun 1.

Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.

Metformin is the first-line therapy for diabetes, even in children, and a promising attractive candidate for drug repurposing. Mitochondria are emerging as crucial targets of metformin action both in the periphery and in the brain. The present study evaluated whether treatment with metformin may rescue brain mitochondrial alterations and contrast the increased oxidative stress in a validated mouse model of Rett syndrome (RTT), a rare neurologic disorder of monogenic origin characterized by severe behavioral and physiological symptoms. Read More

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http://dx.doi.org/10.3390/jcm9061669DOI Listing

Metabolic Profiling of Early and Late Recurrent Pancreatic Ductal Adenocarcinoma Using Patient-Derived Organoid Cultures.

Cancers (Basel) 2020 Jun 1;12(6). Epub 2020 Jun 1.

Department of General and Visceral Surgery, University of Freiburg, Medical Center Faculty of Medicine, 79106 Freiburg, Germany.

Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and will become the second most common cause of cancer-associated mortality by 2030. The poor prognosis arises from a lack of sensitive biomarkers, limited therapeutic options, and the astonishingly high recurrence rate after surgery of 60-80%. The factors driving this recurrence, however, remain enigmatic. Read More

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http://dx.doi.org/10.3390/cancers12061440DOI Listing

Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes.

Nutrients 2020 Jun 1;12(6). Epub 2020 Jun 1.

Department of Hematology, Endocrinology, and Metabolism, Niigata University Faculty of Medicine, 1-757 Asahimachi-dori, Chuoh-ku, Niigata 951-8510, Japan.

The aim of this study was to investigate the association between protein intake and mortality risk in patients with type 2 diabetes. We analyzed a pooled data of 2494 diabetic patients from two prospective longitudinal studies. Nutritional intake was assessed using a Food Frequency Questionnaire at baseline. Read More

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http://dx.doi.org/10.3390/nu12061629DOI Listing

Impact of COVID-19 outbreak measures of lockdown on the Italian Carbon Footprint.

Sci Total Environ 2020 May 29;737:139806. Epub 2020 May 29.

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, Roskilde, Denmark. Electronic address:

Stringent lockdown measures implemented in Italy to mitigate the spread of COVID-19 are generating unprecedented economic impacts. However, the environmental consequences associated with the temporary shutdown and recovery of industrial and commercial activities are still not fully understood. Using the well-known carbon footprint (CF) indicator, this paper provides a comprehensive estimation of environmental effects due to the COVID-19 outbreak lockdown measures in Italy. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139806DOI Listing

Novel bioelectrochemical strategies for domesticating the electron flow in constructed wetlands.

Sci Total Environ 2020 May 21;735:139522. Epub 2020 May 21.

Chemical Engineering Department, Universidad de Alcalá, Alcalá de Henares, Spain; IMDEA Agua, Parque Tecnológico de la Universidad de Alcalá, 28805, Alcalá de Henares, Spain; METfiler, Carrión de los Céspedes, Sevilla, Spain. Electronic address:

Constructed wetlands are an effective biofilter-based technology for treating wastewater in a sustainable way; however, their main disadvantage is a large area footprint. To cope with this limitation a new generation of constructed wetlands, the METlands®, have been recently reported. METlands® replace gravel with a granular electrically conductive material to enhance the oxidative metabolisms of electroactive bacteria by facilitating the flux of electron through the material and, consequently, increase bioremediation rates. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139522DOI Listing

Increasing ovarian NAD levels improve mitochondrial functions and reverse ovarian aging.

Free Radic Biol Med 2020 May 31. Epub 2020 May 31.

Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Engineering Laboratory of Preimplantation Genetic Diagnosis and Screening, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

Loss of follicles together with decreased oocyte quality and quantity contribute to age-associated ovarian senescence and infertility. Although underlying mechanisms for ovarian senescence are still unknown, mitochondrial dysfunctions have been reported. Here, we showed age-dependent decreases in ovarian Nicotinamide Adenine Dinucleotide (NAD) levels in mice whereas supplementing aging mice with nicotinamide riboside (NR), an NAD precursor, increased ovarian NAD content. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2020.05.003DOI Listing

Modest Regulation of Digestive Performance Is Maintained through Early Ontogeny for the American Alligator, .

Physiol Biochem Zool 2020 Jul/Aug;93(4):320-338

The American alligator, , is an opportunistic carnivore that experiences an ontogenetic shift in food and feeding habits with an increase in body size. Alligators frequently feed on invertebrates and small fish as neonates and transition to feeding less frequently on larger vertebrates as they grow. We hypothesized that alligators experience an ontogenetic shift in the regulation of intestinal performance-modest regulation with frequent feeding early in life and wider regulation with less frequent feeding as they increase in body size. Read More

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http://dx.doi.org/10.1086/709443DOI Listing

A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood.

Am J Clin Nutr 2020 Jun 3. Epub 2020 Jun 3.

Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.

Background: Acylcarnitines (ACs) play a major role in fatty acid metabolism and are potential markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic individuals. Diet, and in particular red and processed meat intake, has been shown to influence AC concentrations but data on the effect of meat consumption on AC concentrations is limited.

Objectives: To investigate the effect of red and processed meat intake on AC concentrations in plasma and urine using a randomized controlled trial with replication in an observational cohort. Read More

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http://dx.doi.org/10.1093/ajcn/nqaa140DOI Listing

Perspective: Do Fasting, Caloric Restriction, and Diets Increase Sensitivity to Radiotherapy? A Literature Review.

Adv Nutr 2020 Jun 3. Epub 2020 Jun 3.

Université Caen Normandie, Normandie University, UNICAEN, Medical School, CHU de Caen, Caen, France.

Caloric starvation, as well as various diets, has been proposed to increase the oxidative DNA damage induced by radiotherapy (RT). However, some diets could have dual effects, sometimes promoting cancer growth, whereas proposing caloric restriction may appear counterproductive during RT considering that the maintenance of weight is a major factor for the success of this therapy. A systematic review was performed via a PubMed search on RT and fasting, or caloric restriction, ketogenic diet (>75% of fat-derived energy intake), protein starvation, amino acid restriction, as well as the Warburg effect. Read More

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http://dx.doi.org/10.1093/advances/nmaa062DOI Listing

No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial.

Am J Clin Nutr 2020 Jun 3. Epub 2020 Jun 3.

Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands.

Background: Effects of resveratrol on metabolic health have been studied in several short-term human clinical trials, with conflicting results. Next to dose, the duration of the clinical trials may explain the lack of effect in some studies, but long-term studies are still limited.

Objectives: The objective of this study was to investigate the effects of 6-mo resveratrol supplementation on metabolic health outcome parameters. Read More

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http://dx.doi.org/10.1093/ajcn/nqaa125DOI Listing

A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.

PLoS Comput Biol 2020 Jun 3;16(6):e1007882. Epub 2020 Jun 3.

Nestlé Research, EPFL Innovation Park, Lausanne, Switzerland.

Molecular quantitative trait locus (QTL) analyses are increasingly popular to explore the genetic architecture of complex traits, but existing studies do not leverage shared regulatory patterns and suffer from a large multiplicity burden, which hampers the detection of weak signals such as trans associations. Here, we present a fully multivariate proteomic QTL (pQTL) analysis performed with our recently proposed Bayesian method LOCUS on data from two clinical cohorts, with plasma protein levels quantified by mass-spectrometry and aptamer-based assays. Our two-stage study identifies 136 pQTL associations in the first cohort, of which >80% replicate in the second independent cohort and have significant enrichment with functional genomic elements and disease risk loci. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1007882DOI Listing

Cecal microbiome composition and metabolic function in probiotic treated broilers.

PLoS One 2020 3;15(6):e0225921. Epub 2020 Jun 3.

Department of Animal Sciences, The Ohio State University, Columbus, Ohio, United States of America.

Probiotics have become increasingly popular in the poultry industry as a promising nutritional intervention to promote the modulation of intestinal microbial communities and their metabolic activities as a means of improving health and performance. This study aimed to determine the influence of different probiotic formulations on the taxonomic and metabolic profiling of cecal microbial communities, as well as to define associations between cecal microbiota and growth parameters in 21 and 42-day-old broilers. Probiotics investigated included a synbiotic (SYNBIO), a yeast-based probiotic (YEAST), and three single-strain formulations of spore-forming Bacillus amyloliquefaciens (SINGLE1), B. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225921PLOS

Testosterone replacement therapy in insulin-sensitive hypogonadal men restores phosphatidylcholine levels by regulation of arachidonic acid metabolism.

J Cell Mol Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Science and Technology for Agriculture, Forestry, Nature and Energy (DAFNE), University of Tuscia, Viterbo, Italy.

Male hypogonadism is notoriously associated with altered lipid metabolism. In this study, we performed an untargeted mass spectrometry-based profiling of plasma lipids from twenty healthy and twenty hypogonadal men before and after testosterone replacement therapy (TRT) for 60 days. Results demonstrated that hypogonadism was associated with a significant increase in sphingomyelin (SM), whereas phosphatidylcholine (PC) was mainly cleaved by activated phospholipase-A2 into lysophosphatidylcholine (LPC). Read More

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http://dx.doi.org/10.1111/jcmm.15392DOI Listing

Hardy-Weinberg Equilibrium in different mitochondrial haplogroups of four genes associated with neuroprotection and neurodegeneration.

Arq Neuropsiquiatr 2020 May 29;78(5):269-276. Epub 2020 May 29.

Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Background: Malfunctioning or damaged mitochondria result in altered energy metabolism, redox equilibrium, and cellular dynamics and is a central point in the pathogenesis of neurological disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis. Therefore, it is of utmost importance to identify mitochondrial genetic susceptibility markers for neurodegenerative diseases. Potential markers include the respiratory chain enzymes Riboflavin kinase (RFK), Flavin adenine dinucleotide synthetase (FAD), Succinate dehydrogenase B subunit (SDHB), and Cytochrome C1 (CYC1). Read More

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http://dx.doi.org/10.1590/0004-282x20200002DOI Listing

Neuropeptide Y1 Receptor Antagonist but not Neuropeptide Y itself Increased Bone Mineral Density when Locally Injected with Hyaluronic Acid in Male Wistar Rats.

Turk J Med Sci 2020 Jun 3. Epub 2020 Jun 3.

Background/aim: The nervous system controls bone mass via both the central (CNS) and the peripheral (PNS) nervous systems. Intriguingly, Neuropeptide Y (NPY) signaling occurs in both. Less is known on how the PNS stimulated NPY signaling controls bone metabolism. Read More

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http://dx.doi.org/10.3906/sag-2001-268DOI Listing

Co-catabolism of arginine and succinate drives symbiotic nitrogen fixation.

Mol Syst Biol 2020 Jun;16(6):e9419

Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland.

Biological nitrogen fixation emerging from the symbiosis between bacteria and crop plants holds promise to increase the sustainability of agriculture. One of the biggest hurdles for the engineering of nitrogen-fixing organisms is an incomplete knowledge of metabolic interactions between microbe and plant. In contrast to the previously assumed supply of only succinate, we describe here the CATCH-N cycle as a novel metabolic pathway that co-catabolizes plant-provided arginine and succinate to drive the energy-demanding process of symbiotic nitrogen fixation in endosymbiotic rhizobia. Read More

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http://dx.doi.org/10.15252/msb.20199419DOI Listing

DNA Methylation Associated with Mitochondrial Dysfunction in a South African Autism Spectrum Disorder Cohort.

Autism Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Autism spectrum disorder (ASD) is characterized by phenotypic heterogeneity and a complex genetic architecture which includes distinctive epigenetic patterns. We report differential DNA methylation patterns associated with ASD in South African children. An exploratory whole-epigenome methylation screen using the Illumina 450 K MethylationArray identified differentially methylated CpG sites between ASD and controls that mapped to 898 genes (P ≤ 0. Read More

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http://dx.doi.org/10.1002/aur.2310DOI Listing

Urinary metabolomic signatures in reticular oral lichen planus.

Heliyon 2020 May 22;6(5):e04041. Epub 2020 May 22.

College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guian new area 550025, PR China.

Oral lichen planus (OLP) is a chronic inflammatory disease. Among all the clinical forms in OLP, reticular type has the highest incidence rate. Previous studies have applied metabolomics to investigate the metabolic changes of oral mucosa and blood samples from reticular OLP patients. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256305PMC

Molecular genetic and mitochondrial metabolic analyses confirm the suspected mitochondrial etiology in a pediatric patient with an atypical form of alternating hemiplegia of childhood.

Mol Genet Metab Rep 2020 Sep 28;24:100609. Epub 2020 May 28.

Department of Anatomy and Regenerative Biology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.

Alternative hemiplegia of childhood (AHC) is a rare neurodevelopmental disorder with an extensive phenotypic variability, resulting in a challenging clinical diagnosis. About 75% of AHC cases are caused by pathogenic variants mapping in the , or gene, leaving many AHC patients clinically and genetically undiagnosed. In this study, we report the case of a 9-year old proband clinically diagnosed with an atypical form of AHC presenting a suspected mitochondrial etiology and an obscure genetic diagnosis. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2020.100609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262444PMC
September 2020

Thermal heterogeneity, migration, and consequences for spawning potential of female bull trout in a river-reservoir system.

Ecol Evol 2020 May 3;10(9):4128-4142. Epub 2020 Apr 3.

U.S. Geological Survey Forest and Rangeland Ecosystem Science Center Corvallis Oregon.

The likelihood that fish will initiate spawning, spawn successfully, or skip spawning in a given year is conditioned in part on availability of energy reserves. We evaluated the consequences of spatial heterogeneity in thermal conditions on the energy accumulation and spawning potential of migratory bull trout () in a regulated river-reservoir system. Based on existing data, we identified a portfolio of thermal exposures and migratory patterns and then estimated their influence on energy reserves of female bull trout with a bioenergetics model. Read More

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http://dx.doi.org/10.1002/ece3.6184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244891PMC

High expression of PKM2 synergizes with PD-L1 in tumor cells and immune cells to predict worse survival in human lung adenocarcinoma.

J Cancer 2020 18;11(15):4442-4452. Epub 2020 May 18.

Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.

: Immunotherapy targeting PD-1/PD-L1 represents a breakthrough in the treatment of lung cancer. Pyruvate kinase M2 (PKM2) is not only a critical player in glycolysis, but also conducive to tumor progression and immune response. While both have been linked to lung adenocarcinoma (AC), the correlation and clinical significance of PKM2 and PD-L1 expression in human lung AC tissues remains not entirely explored. Read More

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http://dx.doi.org/10.7150/jca.42610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255362PMC

Quantitative Proteomics Analysis by Sequential Window Acquisition of All Theoretical Mass Spectra-Mass Spectrometry Reveals a Cross-Protection Mechanism for To Tolerate High-Concentration Ammonium Chloride.

J Agric Food Chem 2020 Jun 3. Epub 2020 Jun 3.

Hunan Key Laboratory of Forestry Edible Sources Safety and Processing, Changsha, Hunan 410004, People's Republic of China.

To achieve the accumulation of targeted secondary metabolites, microorganisms must adopt various protection mechanisms to avoid or reduce damage to cells caused by abiotic stresses, which formed from the changes of physical and chemical culture conditions. The protection mechanism of sp. to tolerate high-concentration ammonium chloride was analyzed by sequential window acquisition of all theoretical mass spectra-mass spectrometry proteomics in this work, and the results indicated that abiotic stresses caused by high-concentration ammonium chloride inhibited the synthesis of chitin and glycoprotein, leading to a decrease in cell wall integrity and, thus, affecting cell growth. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c01607DOI Listing

[Exploration on scientific connotation of TCM syndromes and recommended prescriptions against COVID-19 based on TCMTP V2.0].

Zhongguo Zhong Yao Za Zhi 2020 Apr;45(7):1488-1498

Shaanxi Institute of International Trade & Commerce Xi'an 712046, China.

Coronavirus disease 2019(COVID-19) has attracted great attentions from the whole world. Traditional Chinese medicine(TCM) has been widely used and shown satisfying efficacies in treating all stages of COVID-19. In this study, the molecular interaction networks of different stages of COVID-19(the early, severe, critical and recovery stage) were constructed using the links among symptoms-related genes collected from TCMIP V2. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200229.401DOI Listing

Functions of lactate in the brain of rat with intracerebral hemorrhage evaluated with MRI/MRS and in vitro approaches.

CNS Neurosci Ther 2020 Jun 2. Epub 2020 Jun 2.

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.

Introduction: Lactate accumulation in the brain is caused by the anaerobic metabolism induced by ischemic damages, which always accompanies intracerebral hemorrhages (ICH). Our former findings showed that microglia's movement was always directly toward hemorrhagic center with the highest lactate concentration, and penumbra area has the largest density of compactly arrayed microglia. However, the relationship between microglia and lactate concentration has not been well documented. Read More

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http://dx.doi.org/10.1111/cns.13399DOI Listing

Phosphoproteomics and Proteomics Reveal Metabolism as a Key Node in LPS-Induced Acute Inflammation in RAW264.7.

Inflammation 2020 Jun 2. Epub 2020 Jun 2.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People's Republic of China.

To better understand the acute inflammatory mechanisms, the modulation, and to investigate the key node in predicting inflammatory diseases, high-sensitivity LC-MS/MS-based proteomics and phosphoproteomics approaches were used to identify differential proteins in RAW264.7 macrophages with lipopolysaccharide (LPS). Furthermore, differential proteins and their main biological process, as well as signaling pathways, were analyzed through bioinformatics techniques. Read More

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http://dx.doi.org/10.1007/s10753-020-01240-xDOI Listing

Antifungal Effects of Fusion Puroindoline B on the Surface and Intracellular Environment of Aspergillus flavus.

Probiotics Antimicrob Proteins 2020 Jun 1. Epub 2020 Jun 1.

College of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China.

Aspergillus flavus infection is a major issue for safe food storage. In this study, we constructed an efficient prokaryotic expression system for puroindoline B (PINB) protein to detect its antifungal activity. The Puroindoline b gene was cloned into pET-28a (+) vector and expressed in Escherichia coli. Read More

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http://dx.doi.org/10.1007/s12602-020-09667-2DOI Listing
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