509,209 results match your criteria Bioenergetics : open access[Journal]


Metabolic Fingerprinting of Chorionic Villous Samples in Normal Pregnancy and Chromosomal Disorders.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy, Ospedale Pediatrico Microcitemico A.Cao, Cagliari, Italy.

Objective: Placenta-related biological samples are used in biomedical research to investigate placental development. Metabolomics represents a promising approach for studying placental metabolism in an effort to explain physiological and pathological mechanisms. The aim of this study was to investigate metabolic changes in chorionic villi during the first trimester of pregnancy in euploid and aneuploid cases. Read More

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http://dx.doi.org/10.1002/pd.5461DOI Listing

Large cortical bone pores in the tibia are associated with proximal femur strength.

PLoS One 2019 17;14(4):e0215405. Epub 2019 Apr 17.

Berlin-Brandenburg Center for Regenerative Therapies, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Alterations of structure and density of cortical bone are associated with fragility fractures and can be assessed in vivo in humans at the tibia. Bone remodeling deficits in aging women have been recently linked to an increase in size of cortical pores. In this ex vivo study, we characterized the cortical microarchitecture of 19 tibiae from human donors (aged 69 to 94 years) to address, whether this can reflect impairments of the mechanical competence of the proximal femur, i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215405PLOS

GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Glucagon-like peptide-1 (GLP-1) influences energy balance by exerting effects on food intake and glucose metabolism, through mechanisms that are partially dependent on the vagal pathway. The aim of this study was to characterize the effects of chronic GLP-1 stimulation on energy homeostasis and glucose metabolism in the absence of vagal innervation Truncal vagotomized (VGX) and sham operated rats (SHAM) received an intraperitoneal GLP-1 infusion (3.5 pmol/kg/min) trough mini-osmotic pumps. Read More

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http://dx.doi.org/10.1002/jcb.28719DOI Listing

AMP-activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Institute of Digestive Diseases, The First Affiliated Hospital, Nanchang, China.

Adenine monophosphate-activated protein kinase (AMPK) is a fuel sensing enzyme that is activated in shortage of energy and inhibited in its surplus. Cancer is a metabolic disease characteristic of aerobic glycolysis, namely Warburg effect, and possesses heterogeneity featured by spatiotemporal hypoxia and normoxia, where AMPK is deeply implicated. The present study delineates the regulation of mitochondrial functions by AMPK in cancer cells. Read More

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http://dx.doi.org/10.1111/jcmm.14279DOI Listing

Neudesin in obesity and type 2 diabetes mellitus: the effect of acute fasting and weight reducing interventions.

Diabetes Metab Syndr Obes 2019 28;12:423-430. Epub 2019 Mar 28.

Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic,

Context: Neudesin has recently been identified as a novel regulator of energy expenditure in experimental animals; however, its role in humans remains unexplored.

Objective: The aim of this study was to assess the effects of obesity and type 2 diabetes mellitus (T2DM) along with selected weight reducing interventions on serum neudesin levels and adipose tissue mRNA expression.

Patients And Methods: Fifteen obese subjects with T2DM undergoing endoscopic duodenal-jejunal bypass liner (DJBL) implantation, 17 obese subjects (11 with T2DM, 6 without T2DM) scheduled for gastric plication (GP), 15 subjects with functional hypoglycemia subjected to 72-hour acute fasting (AF), and 12 healthy controls were included in the study. Read More

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http://dx.doi.org/10.2147/DMSO.S193259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445223PMC

SIRT4 inhibits the proliferation, migration, and invasion abilities of thyroid cancer cells by inhibiting glutamine metabolism.

Onco Targets Ther 2019 28;12:2397-2408. Epub 2019 Mar 28.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China,

Background: SIRT4, a protein localized in the mitochondria, is one of the least characteristic members of the sirtuin family. It is known that SIRT4 has deacetylase activity and plays a role in energy metabolism, but little is known about its possible role in carcinogenesis. Recently, several studies have suggested that SIRT4 may function as either a tumor oncogene or a tumor suppressor gene. Read More

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http://dx.doi.org/10.2147/OTT.S189536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445187PMC

Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells.

Sci Rep 2019 Apr 16;9(1):6152. Epub 2019 Apr 16.

Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta.

Aspirin is a widely used anti-inflammatory and antithrombotic drug also known in recent years for its promising chemopreventive antineoplastic properties, thought to be mediated in part by its ability to induce apoptotic cell death. However, the full range of mechanisms underlying aspirin's cancer-preventive properties is still elusive. In this study, we observed that aspirin impaired both the synthesis and transport of acetyl-coenzyme A (acetyl-CoA) into the mitochondria of manganese superoxide dismutase (MnSOD)-deficient Saccharomyces cerevisiae EG110 yeast cells, but not of the wild-type cells, grown aerobically in ethanol medium. Read More

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http://dx.doi.org/10.1038/s41598-019-39489-4DOI Listing

CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet.

Sci Rep 2019 Apr 16;9(1):6165. Epub 2019 Apr 16.

Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.

Brown adipose tissue (BAT) plays a role in energy expenditure and is involved in nutrient metabolism. C-X-C chemokine ligand 12 (CXCL12)-CXCR4 pathway regulates the immune, nervous, and cardiovascular systems and affects the adipose tissue. Here, we investigated the role of this pathway as an activator of BAT. Read More

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http://dx.doi.org/10.1038/s41598-019-42127-8DOI Listing

Manipulation of oxidative stress responses as a strategy to generate stress-tolerant crops. From damage to signaling to tolerance.

Crit Rev Biotechnol 2019 Apr 16:1-16. Epub 2019 Apr 16.

a Facultad de Ciencias Bioquímicas y Farmacéuticas, Biología del Estrés en Plantas, Instituto de Biología Molecular y Celular de Rosario (IBR-UNR/CONICET) , Universidad Nacional de Rosario (UNR) , Rosario , Argentina.

Plants exposed to hostile environmental conditions such as drought or extreme temperatures usually undergo oxidative stress, which has long been assumed to significantly contribute to the damage suffered by the organism. Reactive oxygen species (ROS) overproduced under stress conditions were proposed to destroy membrane lipids and to inactivate proteins and photosystems, ultimately leading to cell death. Accordingly, considerable effort has been devoted, over the years, to improve stress tolerance by strengthening antioxidant and dissipative mechanisms. Read More

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https://www.tandfonline.com/doi/full/10.1080/07388551.2019.1
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http://dx.doi.org/10.1080/07388551.2019.1597829DOI Listing
April 2019
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Lipid Droplets: A Significant but Understudied Contributor of Host⁻Bacterial Interactions.

Cells 2019 Apr 15;8(4). Epub 2019 Apr 15.

Division of Biomedical Sciences, College of Osteopathic Medicine, Marian University, 318e Michael A. Evans Center for Health Sciences, 3200 Cold Spring Road, Indianapolis, IN 46222, USA.

Lipid droplets (LDs) are cytosolic lipid storage organelles that are important for cellular lipid metabolism, energy homeostasis, cell signaling, and inflammation. Several bacterial, viral and protozoal pathogens exploit host LDs to promote infection, thus emphasizing the importance of LDs at the host-pathogen interface. In this review, we discuss the thus far reported relation between host LDs and bacterial pathogens including obligate and facultative intracellular bacteria, and extracellular bacteria. Read More

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https://www.mdpi.com/2073-4409/8/4/354
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http://dx.doi.org/10.3390/cells8040354DOI Listing
April 2019
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Dietary Macronutrient Management to Treat Mitochondrial Dysfunction in Parkinson's Disease.

Int J Mol Sci 2019 Apr 15;20(8). Epub 2019 Apr 15.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

Mitochondrial dysfunction has been demonstrated to play an important role in the pathogenesis of Parkinson's disease (PD). The products of several PD-associated genes, including , , , , and , have important roles in mitochondrial biology. Thus, modifying mitochondrial function could be a potential therapeutic strategy for PD. Read More

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http://dx.doi.org/10.3390/ijms20081850DOI Listing

Assessing Cerebral Metabolism in the Immature Rodent: From Extracts to Real-Time Assessments.

Dev Neurosci 2019 Apr 16:1-12. Epub 2019 Apr 16.

Department of Pediatrics and Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA,

Brain development is an energy-expensive process. Although glucose is irreplaceable, the developing brain utilizes a variety of substrates such as lactate and the ketone bodies, β-hydroxybutyrate and acetoacetate, to produce energy and synthesize the structural components necessary for cerebral maturation. When oxygen and nutrient supplies to the brain are restricted, as in neonatal hypoxia-ischemia (HI), cerebral energy metabolism undergoes alterations in substrate use to preserve the production of adenosine triphosphate. Read More

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https://www.karger.com/Article/FullText/496921
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http://dx.doi.org/10.1159/000496921DOI Listing
April 2019
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Deciphering the "elixir of life": Dynamic perspectives into the allosteric modulation of mitochondrial ATP synthase by J147, a novel drug in the treatment of Alzheimer's disease.

Chem Biodivers 2019 Apr 16. Epub 2019 Apr 16.

University of KwaZulu-Natal, Westville, School of Health Sciences, School of Health Sciences, University of, Not Available, 4001, Durban, SOUTH AFRICA.

The discovery of J147 represented a significant milestone in the treatment of age-related disorders, which was further augmented by the recent identification of mitochondrial ATP synthase as the therapeutic target. However, the underlying molecular events associated with the modulatory activity of J147 has remained unresolved till date. Herein, we present, for the first time, a dynamical approach to investigate the allosteric regulation of mATP synthase by J147, using a reliable human αγβ protein model. Read More

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http://dx.doi.org/10.1002/cbdv.201900085DOI Listing
April 2019
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[Ghrelin Physiology and Pathophysiology: Focus on the Cardiovascular System].

Kardiologiia 2019 Apr 13;59(3):60-67. Epub 2019 Apr 13.

Research Institute for Complex Issues of Cardiovascular Diseases Kemerovo State Medical University.

Ghrelin is a multifunctional peptide hormone, mainly synthesized by P / D1 cells of the stomach fundus mucosa. Its basic effect, which is realized via GHS-R1 α receptor in the arcuate and the ventromedial nucleuses of hypothalamus, is stimulation of the synthesis of pituitary hormones. Ghrelin is involved in control of appetite and energy balance, regulation of carbohydrate and lipid metabolism, cell proliferation and apoptosis, as well as modulation of functioning of gastrointestinal, cardiovascular, pulmonary and immune systems. Read More

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https://lib.ossn.ru/jour/article/view/569
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http://dx.doi.org/10.18087/cardio.2019.3.10220DOI Listing
April 2019
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[Study on proteins in Guangdilong by nano LC/orbitrap fusion lumos HR-MS].

Zhongguo Zhong Yao Za Zhi 2019 Jan;44(2):324-331

Shanghai Institute for Food and Drug Control Shanghai 201203,China Shanghai Institute of Pharmaceutical Industry Shanghai 201203,China.

In the present study,fresh Guangdilong( GD),originating from Pheretima aspergillum,was taken as the object. The total proteins from GD were firstly separated by SDS-PAGE according to their molecular weights and in-gel digestion was then performed.After that,the peptides were analyzed by nano LC/orbitrap fusion lumos high resolution mass spectrometry( nano LC/orbitrap fusion lumos HR-MS). Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181009.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181009.012DOI Listing
January 2019
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[Research progress on pathogenesis of ischemic stroke and traditional Chinese medicine commonly used for treatment of ischemic stroke].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(3):422-432

Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.

Stroke has become the second leading cause of death in the world, and the most common type is the ischemic stroke. Due to its rapid onset and complex conditions, ischemic stroke is a major neurological disorder that causes disability. Ischemic stroke mainly results from atherosclerosis, and the pathogenesis of ischemic stroke mainly includes energy metabolism disorders in the brain, the toxicity of excitatory amino acids, oxidative/nitrification stress, inflammatory response, apoptosis, and autophagy. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20180921.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180921.002DOI Listing
February 2019
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[~1H-NMR-based metabonomics analysis of the acute hepatotoxicity mechanism of Artemisia argyi essential oil].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(4):827-832

College of Traditional Chinese Medicine,Ji'nan University Guangzhou 510632,China.

This study based on~1H-NMR urine metabolomics technique combined with biochemical indicators to focus on studying the acute hepatotoxicity mechanism of Artemisia argyi essential oil( AAEO). In order to further explore the acute hepatotoxicity mechanism of AAEO,the researchers collected the urine nuclear magnetic data of rats in different periods of high and low doses of olive oil and AAEO group. Using the principal component analysis( PCA) and orthogonal partial least squares-discrimination analysis( OPLSDA) to analyze the endogenous small molecule metabolites in rat urine to study the effects of AAEO on the metabolic process of normal rats. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181128.006DOI Listing
February 2019

Shear stress and oxygen availability drive differential changes in OK proximal tubule cell metabolism and endocytosis.

Traffic 2019 Apr 15. Epub 2019 Apr 15.

Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.

Kidney proximal tubule (PT) cells have high metabolic demands to drive the extraordinary ion and solute transport, water reabsorption, and endocytic uptake that occur in this nephron segment. Increases in renal blood flow alter glomerular filtration rate (GFR) and lead to rapid mechanosensitive adaptations in PT transport, impacting metabolic demand. Although the PT reabsorbs essentially all of the filtered glucose, PT cells rely primarily on oxidative metabolism rather than glycolysis to meet their energy demands. Read More

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http://dx.doi.org/10.1111/tra.12648DOI Listing

The role of fish life histories in allometrically scaled food-web dynamics.

Ecol Evol 2019 Mar 21;9(6):3651-3660. Epub 2019 Feb 21.

Department of Biological and Environmental Science University of Jyväskylä Jyväskylä Finland.

Body size determines key ecological and evolutionary processes of organisms. Therefore, organisms undergo extensive shifts in resources, competitors, and predators as they grow in body size. While empirical and theoretical evidence show that these size-dependent ontogenetic shifts vastly influence the structure and dynamics of populations, theory on how those ontogenetic shifts affect the structure and dynamics of ecological networks is still virtually absent. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ece3.4996
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http://dx.doi.org/10.1002/ece3.4996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434563PMC
March 2019
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Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates.

J Biol Chem 2019 Apr 15. Epub 2019 Apr 15.

University of California Davis.

Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis associated () gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases of metabolism. However, adropin's roles in human metabolism are unclear. expression profiling in a nonhuman primate diurnal transcriptome atlas (GSE98965) revealed a dynamic and diurnal pattern of expression. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007528DOI Listing

Weight loss probiotic supplementation effect in overweight and obesity subjects: A review.

Clin Nutr 2019 Apr 3. Epub 2019 Apr 3.

Curso de Nutrição do Centro Universitário São Camilo, São Paulo, SP, Brazil; Brazilian Association of Sport Nutrition, São Paulo, SP, Brazil; Universidade de São Paulo, Programa de Pós-graduação em Nutrição em Saúde Pública, São Paulo, SP, Brazil. Electronic address:

Obese individuals present adverse changes in the diversity and composition of the gut microbiota, leading to alterations in energy balance, lipid metabolism, endocrine disturbances, and low-grade chronic systemic inflammation increases. Probiotic supplementation appears to change gut microbiota by decrease gut permeability, inflammation, and metabolic disorders, creating a promising environment to weight loss. This revision resumes the main findings of probiotic supplementation and weight loss that contributed to building the current background linking changes in gut microbiota profile and with obesity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193014
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http://dx.doi.org/10.1016/j.clnu.2019.03.034DOI Listing
April 2019
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The Metabolomic Signatures of Weight Change.

Metabolites 2019 Apr 4;9(4). Epub 2019 Apr 4.

Department of Twin Research, King's College London, London SE1 7EH, UK.

Obesity represents a major health concern, not just in the West but increasingly in low and middle income countries. In order to develop successful strategies for losing weight, it is essential to understand the molecular pathogenesis of weight change. A number of pathways, implicating oxidative stress but also the fundamental regulatory of insulin, have been implicated in weight gain and in the regulation of energy expenditure. Read More

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https://www.mdpi.com/2218-1989/9/4/67
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http://dx.doi.org/10.3390/metabo9040067DOI Listing
April 2019
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Metalloproteins in the Biology of Heterocysts.

Life (Basel) 2019 Apr 3;9(2). Epub 2019 Apr 3.

Institute for Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue-Straβe 9, 60438 Frankfurt am Main, Germany.

Cyanobacteria are photoautotrophic microorganisms present in almost all ecologically niches on Earth. They exist as single-cell or filamentous forms and the latter often contain specialized cells for N₂ fixation known as heterocysts. Heterocysts arise from photosynthetic active vegetative cells by multiple morphological and physiological rearrangements including the absence of O₂ evolution and CO₂ fixation. Read More

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https://www.mdpi.com/2075-1729/9/2/32
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http://dx.doi.org/10.3390/life9020032DOI Listing
April 2019
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Delayed Feeding Alters Transcriptional and Post-Transcriptional Regulation of Hepatic Metabolic Pathways in Peri-Hatch Broiler Chicks.

Genes (Basel) 2019 Apr 3;10(4). Epub 2019 Apr 3.

Department of Animal Science, North Carolina State University, Raleigh, NC 27607, USA.

Hepatic fatty acid oxidation of yolk lipoproteins provides the main energy source for chick embryos. Post-hatching these yolk lipids are rapidly exhausted and metabolism switches to a carbohydrate-based energy source. We recently demonstrated that many microRNAs (miRNAs) are key regulators of hepatic metabolic pathways during this metabolic switching. Read More

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http://dx.doi.org/10.3390/genes10040272DOI Listing

Host⁻MicroRNA⁻Microbiota Interactions in Colorectal Cancer.

Genes (Basel) 2019 Apr 2;10(4). Epub 2019 Apr 2.

Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.

Changes in gut microbiota composition have consistently been observed in patients with colorectal cancer (CRC). Yet, it is not entirely clear how the gut microbiota interacts with tumor cells. We know that tumor cells undergo a drastic change in energy metabolism, mediated by microRNAs (miRNAs), and that tumor-derived miRNAs affect the stromal and immune cell fractions of the tumor microenvironment. Read More

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https://www.mdpi.com/2073-4425/10/4/270
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http://dx.doi.org/10.3390/genes10040270DOI Listing
April 2019
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Molecular Mechanisms Controlled by mTOR in Male Reproductive System.

Int J Mol Sci 2019 Apr 2;20(7). Epub 2019 Apr 2.

Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal.

In recent years, the mammalian target of rapamycin (mTOR) has emerged as a master integrator of upstream inputs, such as amino acids, growth factors and insulin availability, energy status and many others. The integration of these signals promotes a response through several downstream effectors that regulate protein synthesis, glucose metabolism and cytoskeleton organization, among others. All these biological processes are essential for male fertility, thus it is not surprising that novel molecular mechanisms controlled by mTOR in the male reproductive tract have been described. Read More

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http://dx.doi.org/10.3390/ijms20071633DOI Listing

The regulation of N-acyl-homoserine lactones (AHLs)-based quorum sensing on EPS secretion via ATP synthetic for the stability of aerobic granular sludge.

Sci Total Environ 2019 Apr 5;673:83-91. Epub 2019 Apr 5.

Institute of Environmental Pollution Control and Treatment, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Key Laboratory for Water Pollution Control and Environmental Safety, Hangzhou 310058, China; Zhejiang Provincial Engineering Laboratory of Water Pollution Control, 388 Yuhangtang Road, Hangzhou 310058, China. Electronic address:

According to the relationship among microbial activity, quorum sensing (QS) and structural stability of aerobic granular sludge, the mechanism of QS regulation for microbial activity and granular stability was investigated in AGS process. Results showed that ATP content decreased sharply from 1.8 μmol/gVSS of stable granules to 0. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.052DOI Listing
April 2019
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Effect of raw potato starch on the gut microbiome and metabolome in mice.

Int J Biol Macromol 2019 Apr 12. Epub 2019 Apr 12.

Research Group of Healthcare, Korea Food Research Institute, Wanju 55365, Republic of Korea. Electronic address:

The gut microbiome plays a pivotal role in human health and is affected by various factors. To investigate the association between phenotypic and microbiota-related changes in the gut and a raw starch-based diet, we fed mice with different starch substitutes (corn, wheat, rice, and potato) for 16 weeks. The potato starch-fed group showed the lowest weight gain and fat tissue accumulation of all the groups, as well as the highest insulin sensitivity. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.085DOI Listing

Mechanism and impact of catecholamine conversion by Vibrio cholerae.

Biochim Biophys Acta Bioenerg 2019 Apr 12. Epub 2019 Apr 12.

Institute of Microbiology, University of Hohenheim, Stuttgart, Germany. Electronic address:

Bacterial pathogens are influenced by signaling molecules including the catecholamines adrenaline and noradrenaline which are host-derived hormones and neurotransmitters. Adrenaline and noradrenaline modulate growth, motility and virulence of bacteria. We show that adrenaline is converted by the pathogen Vibrio cholerae to adrenochrome in the course of respiration, and demonstrate that superoxide produced by the respiratory, Na - translocating NADH:quinone oxidoreductase (NQR) acts as electron acceptor in the oxidative conversion of adrenaline to adrenochrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00052728193003
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http://dx.doi.org/10.1016/j.bbabio.2019.04.003DOI Listing
April 2019
2 Reads

Role of global aberrant alternative splicing events in papillary thyroid cancer prognosis.

Aging (Albany NY) 2019 Apr;11(7):2082-2097

Department of Medical Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P. R. China.

Background: Alternative splicing events have been increasingly reported for anomalous perturbations in various cancers, including papillary thyroid cancer (PTC).

Methods: Integration analysis of RNA sequencing and clinical information were utilized to identify survival associated splicing events in PTC. Then, several prognosis-related splicing events were submitted to develop moderate predictors for survival monitoring by using least absolute shrinkage and selection operator model. Read More

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http://dx.doi.org/10.18632/aging.101902DOI Listing

Glycated Hemoglobin, but not Insulin Sensitivity, is Associated with Memory in Subjects with Obesity.

Obesity (Silver Spring) 2019 Apr 15. Epub 2019 Apr 15.

Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute, Dr. Josep Trueta University Hospital, Center for Physiopathology of Obesity and Nutrition, Girona, Spain.

Objective: Obesity has been related to later-life dementia. Serum glucose levels and insulin resistance are known to influence cognition in individuals with diabetes. This study aimed to evaluate memory function in middle-aged individuals with obesity in association with glucose metabolism and brain iron content. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.22457
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http://dx.doi.org/10.1002/oby.22457DOI Listing
April 2019
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The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway.

Evid Based Complement Alternat Med 2019 10;2019:5421528. Epub 2019 Mar 10.

School of Life Science, Beijing Institute of Technology, Beijing 100081, China.

So far, more than 25,000 brain diseases have been shown to be related to oxidative stress. Excessive free radicals and reactive oxygen species (ROS) can attack cells resulting in dysfunctional proteins, lipids, and nucleic acid, finally leading to imbalance of energy metabolism, cell death, gene mutation, and immune reaction. Therefore oxidative stress plays an important role in neuronal diseases. Read More

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https://www.hindawi.com/journals/ecam/2019/5421528/
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http://dx.doi.org/10.1155/2019/5421528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431467PMC
March 2019
2 Reads

iTRAQ-Based Quantitative Proteomics and Transcriptomics Provide Insights Into the Importance of Expansins During Root Development in Carrot.

Front Genet 2019 29;10:247. Epub 2019 Mar 29.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, Ministry of Agriculture and Rural Affairs Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in East China, College of Horticulture, Nanjing Agricultural University, Nanjing, China.

Carrot is an important root vegetable crop with a variety of nutrients. As the main product of carrots, the growth and development of fleshy roots directly determine the yield and quality of carrots. However, molecular mechanism underlying the carrot root formation and expansion is still limited. Read More

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http://dx.doi.org/10.3389/fgene.2019.00247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449468PMC

Comparative Genomic Analysis of the Regulation of Aromatic Metabolism in Betaproteobacteria.

Front Microbiol 2019 29;10:642. Epub 2019 Mar 29.

Institute for Information Transmission Problems RAS (The Kharkevich Institute), Moscow, Russia.

Aromatic compounds are a common carbon and energy source for many microorganisms, some of which can even degrade toxic chloroaromatic xenobiotics. This comparative study of aromatic metabolism in 32 Betaproteobacteria species describes the links between several transcription factors (TFs) that control benzoate (BenR, BenM, BoxR, BzdR), catechol (CatR, CatM, BenM), chlorocatechol (ClcR), methylcatechol (MmlR), 2,4-dichlorophenoxyacetate (TfdR, TfdS), phenol (AphS, AphR, AphT), biphenyl (BphS), and toluene (TbuT) metabolism. We characterize the complexity and variability in the organization of aromatic metabolism operons and the structure of regulatory networks that may differ even between closely related species. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449761PMC

Revisiting the Role of Exercise Countermeasure on the Regulation of Energy Balance During Space Flight.

Front Physiol 2019 29;10:321. Epub 2019 Mar 29.

Université de Strasbourg, Centre National de la Recherche Scientifique, Institut Pluridisciplinaire Hubert Curien UMR 7178, Strasbourg, France.

A body mass loss has been consistently observed in astronauts. This loss is of medical concern since energy deficit can exacerbate some of the deleterious physiological changes observed during space flight including cardiovascular deconditioning, bone density, muscle mass and strength losses, impaired exercise capacity, and immune deficiency among others. These may jeopardize crew health and performance, a healthy return to Earth and mission's overall success. Read More

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http://dx.doi.org/10.3389/fphys.2019.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449861PMC

Conditional Knockout of Raptor/mTORC1 Results in Dentin Malformation.

Front Physiol 2019 29;10:250. Epub 2019 Mar 29.

Department of Pediatric Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

mTORC1 signaling plays an important role in extracellular and intracellular signals, including growth factors, nutrients, energy metabolism, and stress. However, the functional role of mTORC1 in dentinogenesis is unknown. To study the role of Raptor/mTORC1 in dentinogenesis, an Raptor; Osx-Cre (Rap-Osx) mouse, in which Raptor was conditionally deleted in odontoblasts and dental mesenchymal cells, was generated, and postnatal tooth development was compared between Rap-Osx mice and control littermates. Read More

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http://dx.doi.org/10.3389/fphys.2019.00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449869PMC

Photobiomodulation and Coenzyme Q Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice.

Front Cell Neurosci 2019 19;13:74. Epub 2019 Mar 19.

Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Disturbances in mitochondrial biogenesis and bioenergetics, combined with neuroinflammation, play cardinal roles in the cognitive impairment during aging that is further exacerbated by transient cerebral ischemia. Both near-infrared (NIR) photobiomodulation (PBM) and Coenzyme Q (CoQ) administration are known to stimulate mitochondrial electron transport that potentially may reverse the effects of cerebral ischemia in aged animals. We tested the hypothesis that the effects of PBM and CoQ, separately or in combination, improve cognition in a mouse model of transient cerebral ischemia superimposed on a model of aging. Read More

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http://dx.doi.org/10.3389/fncel.2019.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434313PMC

The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain.

Front Neurosci 2019 29;13:292. Epub 2019 Mar 29.

Research Group on Biology of Exercise, Department of Health Sciences, Centro Araranguá, Federal University of Santa Catarina, Araranguá, Brazil.

In understanding the pathology of neurological diseases, the role played by brain energy metabolism is gaining prominence. Animal models have demonstrated that regular physical exercise improves brain energy metabolism while also providing antidepressant, anxiolytic, antioxidant and neuroprotective functions. This review summarizes the latest evidence on the roles played by peroxisome proliferator-activated receptor gamma (PPAR-γ) coactivator 1-alpha (PGC-1α) and mitochondrial uncoupling protein (UCP) in this scenario. Read More

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http://dx.doi.org/10.3389/fnins.2019.00292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449457PMC

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis.

Elife 2019 Apr 15;8. Epub 2019 Apr 15.

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, United States.

Transcription is tightly regulated to maintain energy homeostasis during periods of feeding or fasting, but the molecular factors that control these alternating gene programs are incompletely understood. Here, we find that the B cell lymphoma 6 (BCL6) repressor is enriched in the fed state and converges genome-wide with PPARα to potently suppress the induction of fasting transcription. Deletion of hepatocyte enhances lipid catabolism and ameliorates high-fat-diet-induced steatosis. Read More

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https://elifesciences.org/articles/43922
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http://dx.doi.org/10.7554/eLife.43922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464608PMC
April 2019
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Low-calorie sweetener use, weight, and metabolic health among children: A mini-review.

Pediatr Obes 2019 Apr 14:e12521. Epub 2019 Apr 14.

Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.

A reduction in the consumption of added sugars and sugar-sweetened beverages (SSBs) is a key focus of public health recommendations for a healthy diet among children. One approach to lower added sugar intake is to instead use low-calorie sweeteners (LCSs), which contain no or few calories. Consumption of LCSs is increasing worldwide, with the most marked rise observed among children and adolescents. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijpo.12521
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http://dx.doi.org/10.1111/ijpo.12521DOI Listing
April 2019
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Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.

Clin Res Hepatol Gastroenterol 2019 Apr 11. Epub 2019 Apr 11.

Applied Bioenergetics Lab, Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia; Faculty of Health Sciences, University of Pécs, Pécs, Hungary. Electronic address:

Background And Aims: While non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, its treatment remains elusive. Since metabolic impairment plays a major role in NAFLD pathogenesis, any pharmaceuticals, such as molecular hydrogen (H), that advance lipid and glucose metabolism could be appropriate to tackle this complex condition. The aim of this study was to analyze the effects of 28-day hydrogen-rich water intake on liver fat deposition, body composition and lab chemistry profiles in overweight patients suffering from mild-to-moderate NAFLD. Read More

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http://dx.doi.org/10.1016/j.clinre.2019.03.008DOI Listing

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production.

Cell Metab 2019 Apr 8. Epub 2019 Apr 8.

Departments of Pharmacology and Pathology, University of California San Diego, La Jolla, CA, 92037, USA. Electronic address:

Choline is a vitamin-like nutrient that is taken up via specific transporters and metabolized by choline kinase, which converts it to phosphocholine needed for de novo synthesis of phosphatidylcholine (PC), the main phospholipid of cellular membranes. We found that Toll-like receptor (TLR) activation enhances choline uptake by macrophages and microglia through induction of the choline transporter CTL1. Inhibition of CTL1 expression or choline phosphorylation attenuated NLRP3 inflammasome activation and IL-1β and IL-18 production in stimulated macrophages. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15504131193013
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http://dx.doi.org/10.1016/j.cmet.2019.03.011DOI Listing
April 2019
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17.565 Impact Factor

Optimization of the neurosurgical patient in Intensive Care.

Med Intensiva 2019 Apr 11. Epub 2019 Apr 11.

Servicio de Medicina Intensiva, Hospital Vall d'Hebron, Barcelona, España.

Neurosurgical patients frequently require admission to intensive care units, either for postoperative management or for treating complications. Most neurosurgical diseases require specific monitoring and prophylaxis. The basic principle of neurosurgical patient management is to ensure correct brain tissue perfusion, i. Read More

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http://dx.doi.org/10.1016/j.medin.2019.02.011DOI Listing

Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics.

Biochim Biophys Acta Mol Cell Res 2019 Jul 26;1866(7):1068-1078. Epub 2018 Oct 26.

Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, 35131 Padova, Italy.

The versatility of mitochondrial metabolism and its fine adjustments to specific physiological or pathological conditions regulate fundamental cell pathways, ranging from proliferation to apoptosis. In particular, Ca signalling has emerged as a key player exploited by mitochondria to tune their activity according with cell demand. The functional interaction between mitochondria and endoplasmic reticulum (ER) deeply impacts on the correct mitochondrial Ca signal, thus modulating cell bioenergetics and functionality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183047
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http://dx.doi.org/10.1016/j.bbamcr.2018.10.016DOI Listing
July 2019
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No Difference in Magnesium Intake between Obese Women and Healthy Controls.

Int J Vitam Nutr Res 2019 Apr 15:1-7. Epub 2019 Apr 15.

1 Department of Nutrition, Federal University of Piauí, Ministro Petrônio Portella Campus, Ininga, Teresina, Piauí, Brazil.

Magnesium is a predominantly intracellular ion and plays an important role in energy metabolism and in the maintenance of energy homeostasis. This study aimed to estimate the dietary intake of magnesium and its association with adiposity parameters in obese women. This cross-sectional study included 125 women, aged between 20 and 50 years, who were divided into two groups: obese group (n = 62) and control group (n = 63). Read More

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http://dx.doi.org/10.1024/0300-9831/a000413DOI Listing

The Role of Zinc in Thyroid Hormones Metabolism.

Int J Vitam Nutr Res 2019 Apr 15:1-9. Epub 2019 Apr 15.

1 Nutrition Department, Federal University of Piauí, Campus Minister Petrônio Portella, Ininga, Teresina, Piauí, Brazil.

Thyroid hormones play an important role in body homeostasis by facilitating metabolism of lipids and glucose, regulating metabolic adaptations, responding to changes in energy intake, and controlling thermogenesis. Proper metabolism and action of these hormones requires the participation of various nutrients. Among them is zinc, whose interaction with thyroid hormones is complex. Read More

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https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000262
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http://dx.doi.org/10.1024/0300-9831/a000262DOI Listing
April 2019
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Skeletal muscle proteome analysis provides insights on high altitude adaptation of yaks.

Mol Biol Rep 2019 Apr 13. Epub 2019 Apr 13.

Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610064, China.

The differences in proteome profile of longissimus thoracis (LT) muscles of yak (Bos grunniens) and cattle (Bos taurus) were investigated employing isobaric tag for relative and absolute quantification (iTRAQ) approach to identify differentially expressed proteins and to understand the cellular level adaptations of yaks to high altitudes. Fifty-two proteins were differentially expressed in the two species, among which 20 were up-regulated and 32 were down-regulated in yaks. Gene ontology (GO) annotation revealed that most of the differentially expressed proteins were involved in the molecular function of protein binding, catalytic activity, and structural activity. Read More

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http://dx.doi.org/10.1007/s11033-019-04732-8DOI Listing

The effects of Roundup® in embryo development and energy metabolism of the zebrafish (Danio rerio).

Comp Biochem Physiol C Toxicol Pharmacol 2019 Apr 11. Epub 2019 Apr 11.

Laboratório Integrado de Bioquímica Hatisaburo Masuda, NUPEM, Núcleo em Ecologia e Desenvolvimento Ambiental de Macaé, Universidade Federal do Rio de Janeiro, Avenida São José Barreto, N° 764, Bairro: São José do Barreto, Macaé, RJ CEP: 27.965-045, Brazil. Electronic address:

Roundup® is currently the most widely used and sold agricultural pesticide in the world. The objective of this work was to investigate the effects of Roundup® on energy metabolism during zebrafish (Danio rerio) embryogenesis. The embryo toxicity test was performed for 96 h post-fertilisation and the sublethal concentration of Roundup® was defined as 58. Read More

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http://dx.doi.org/10.1016/j.cbpc.2019.04.007DOI Listing

Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir.

Biochim Biophys Acta Gen Subj 2019 Apr 11. Epub 2019 Apr 11.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Italy. Electronic address:

Background: Altered energy metabolism is a biochemical fingerprint of cancer cells, widely recognized as one of the "hallmarks of cancer". Cancer cells show highly increased rates of glucose uptake and glycolysis, after which the resulting pyruvate is converted to lactate. The maintenance of this metabolic asset is warranted by lactate dehydrogenase A (LDH-A) and for this reason the development of novel LDH-targeted anticancer therapeutics is underway. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.04.008DOI Listing

Gonadotropin regulates NUCB2/nesfatin-1 expression in the mouse ovary and uterus.

Biochem Biophys Res Commun 2019 Apr 10. Epub 2019 Apr 10.

Department of Bioenvironmental Technology, College of Natural Sciences, Seoul Women's University, Seoul 01797, South Korea. Electronic address:

NUCB2/nesfatin-1 is expressed in the hypothalamus and regulates food intake and energy metabolism. Recent studies showed that NUCB2/nesfatin-1 also plays a role in other organs. However, its expression pattern and function in female reproductive organs are unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193063
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2019.04.008DOI Listing
April 2019
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