8,118 results match your criteria Biochimie[Journal]


MiR-204-5p promotes apoptosis and inhibits migration of osteosarcoma via targeting EBF2.

Biochimie 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopedics, The 306th Hospital of PLA, Beijing, 100101, China. Electronic address:

Osteosarcoma is one of the most malignant cancer adolescents and young adults and metastatic osteosarcoma is a huge life threat with a 5-year survival lower than 20%. However, the mechanisms through which localized osteosarcoma turned metastatic are not fully understood. Here, we studied the role of miR-204-5p in osteosarcoma and found that miR-204-5p is downregulated in both osteosarcoma patients and osteosarcoma cell lines. Read More

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December 2018

Folate and choline absorption and uptake: Their role in fetal development.

Biochimie 2018 Dec 6. Epub 2018 Dec 6.

Institute of Human Nutrition and Dietetics, Poznań University of Life Sciences.

Scope: In this review, we attempt to assess how choline and folate transporters affect fetal development. We focus on how the expression of these transporters in response to choline and folate intake affects transport effectiveness. We additionally describe allelic variants of the genes encoding these transporters and their phenotypic effects. Read More

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December 2018

SOS genes contribute to Bac8c induced apoptosis-like death in Escherichia coli.

Biochimie 2018 Dec 5;157:195-203. Epub 2018 Dec 5.

School of Life Sciences, BK 21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daehakro 80, Bukgu, Daegu, 41566, Republic of Korea. Electronic address:

Antimicrobial peptides are one of the promising substitutes for conventional antibiotics. To examine their potential usefulness for controlling bacterial infections, the present study aimed to determine the induction of the self-destruction of Escherichia coli mediated by bac8c, which was modified from template peptide bactenecin. The potential of bac8c (RIWVIWRR) was reflected by the change in physiological following exposure, which led to the accumulation of reactive oxygen species (ROS) with an imbalance in the antioxidant system and damage to the intracellular lipids. Read More

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December 2018

Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4 T lymphocytes and prevents the progression of apoptosis.

Biochimie 2018 Dec 3;157:158-176. Epub 2018 Dec 3.

Institute of Biomedical Chemistry, Pogodinskaya St 10/8, 119121, Moscow, Russia.

Apoptotic endonucleases act cooperatively to fragment DNA and ensure the irreversibility of apoptosis. However, very little is known regarding the potential regulatory links between endonucleases. Deoxyribonuclease 1 (DNase I) inactivation is caused by alternative splicing (AS) of DNase I pre-mRNA skipping exon 4, which occurs in response to EndoG overexpression in cells. Read More

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December 2018
1 Read

Thermodynamic investigation of kissing-loop interactions.

Biochimie 2018 Nov 28;157:177-183. Epub 2018 Nov 28.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE, 68198-6025, USA. Electronic address:

Kissing loop interactions (KLIs) are a common motif that is critical in retroviral dimerization, viroid replication, mRNA, and riboswitches. In addition, KLIs are currently used in a variety of biotechnology applications, such as in aptamer sensors, RNA scaffolds and to stabilize vaccines for therapeutics. Here we describe the thermodynamics of a basic intramolecular DNA capable of engaging in a KLI, consisting of two hairpins connected by a flexible linker. Read More

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November 2018
4 Reads

Serotonergic neurotransmission manipulation for the understanding of brain development and function: learning from Tph2 genetic models.

Biochimie 2018 Dec 1. Epub 2018 Dec 1.

Department of Biology, Unit of Cell and Developmental Biology, University of Pisa, Pisa, 56127, Italy; Istituto Italiano di Tecnologia, Center for Neuroscience and Cognitive Systems @UniTn, Rovereto, 38068, Italy. Electronic address:

Serotonin (5-hydroxytriptamine; 5-HT) is a fascinating neurotransmitter that thanks to an extensive axonal network is released throughout the entire central nervous system (CNS) and exerts its action on the modulation of a countless number of physiological, behavioral and cognitive processes. In addition, cumulating evidences have linked alteration in 5-HT neurotransmission with the onset of psychiatric and neurodevelopmental disorders, such as depression, autisms and schizophrenia. Nevertheless only 5% of the total body content of serotonin exerts its action in the CNS, while the rest is synthetized and stored in peripheral tissues where it acts as an autacoid. Read More

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December 2018
1 Read

Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.

Biochimie 2018 Dec 1. Epub 2018 Dec 1.

Department of Biological Sciences and Technology, National University of Tainan, Tainan, Taiwan. Electronic address:

SEPTIN12 (SEPT12) is a testis-enriched gene that is downregulated in the testis of infertile men with severe spermatogenic defects. While SEPT12 is involved in spermatogenic failure and sperm motility disorder, SEPT12 transcriptional regulation is still unknown. Here we report the promoter region of SEPT12 as a 245 bp segment upstream from the transcription start site. Read More

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December 2018
2 Reads

Oleate increase neutral lipid accumulation, cellular respiration and rescues palmitate-exposed GLP-1 secreting cells by reducing ceramide-induced ROS.

Biochimie 2018 Dec 1. Epub 2018 Dec 1.

Södertälje Hospital, Department of Internal Medicine, SE, 152 86, Södertälje, Sweden; Karolinska Institute, Department of Molecular Medicine and Surgery, Stockholm, Sweden; Uppsala University, Department of Medical Cell Biology, Uppsala, Sweden. Electronic address:

Background: Fatty acids (FAs), and especially monounsaturated FAs (MUFAs) stimulate GLP-1 release. However, lipotoxicity is indicated in GLP-1 secreting cells following long-term exposure to elevated levels of saturated FAs (SFAs) in vivo and in vitro, where in vitro studies indicate that cosupplementation with MUFAs confers lipoprotection. SFAs and MUFAs differentially affect the fate of cells in ways that depend on the cell type, concentration and ratio of the FAs. Read More

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December 2018
1 Read

Parametric study of immobilized cellulase-polymethacrylate particle for the hydrolysis of carboxymethyl cellulose.

Biochimie 2018 Dec 1. Epub 2018 Dec 1.

Bioprocess Engineering Research Group, Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400, Kota Kinabalu, Sabah, Malaysia. Electronic address:

Biocarriers are pivotal in enhancing the reusability of biocatalyst that would otherwise be less economical for industrial application. Ever since the induction of enzymatic technology, varied materials have been assessed for their biocompatibility with enzymes of distinct functionalities. Herein, cellulase was immobilized onto polymethacrylate particles (ICP) as the biocarrier grafted with ethylenediamine (EDA) and glutaraldehyde (GA). Read More

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December 2018
1 Read

Long noncoding RNA NPCCAT1 promotes nasopharyngeal carcinoma progression via upregulating YY1.

Biochimie 2018 Nov 24;157:184-194. Epub 2018 Nov 24.

Department of Rhinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. Electronic address:

Long noncoding RNAs (lncRNAs) are frequently implicated in various cancers. However, the significances of lncRNAs in nasopharyngeal carcinoma (NPC) are largely unclear. In this study, we identified a novel lncRNA nasopharyngeal carcinoma copy number amplified transcript-1 (NPCCAT1), whose expression is increased in NPC tissues compared with nasopharyngeal normal tissues. Read More

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November 2018
2 Reads
2.963 Impact Factor

Thermodynamic signature of indoloquinolines interacting with G-quadruplexes: Impact of ligand side chain.

Biochimie 2018 Nov 24;157:142-148. Epub 2018 Nov 24.

Institute of Biochemistry, Universität Greifswald, Felix-Hausdorff-Str. 4, D-17487, Greifswald, Germany. Electronic address:

Binding of indoloquinolines with different aliphatic side chains to a parallel G-quadruplex derived from the MYC promoter sequence was characterized by optical and calorimetric measurements. ITC experiments performed at different temperatures enabled the determination of molar heat capacity changes upon quadruplex binding and a partitioning of the total binding free enthalpy into contributing terms with hydrophobic effects being major driving forces for all derivatives. Whereas affinities increase for indoloquinolines equipped with a long and positively charged side arm, the highest contribution of specific intermolecular interactions anticipated to impart enhanced specificity is found for a ligand with an uncharged ether aliphatic tail. Read More

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November 2018

Thermodynamics and site stoichiometry of DNA binding by a large antiviral hairpin polyamide.

Biochimie 2018 Nov 24;157:149-157. Epub 2018 Nov 24.

Department of Chemistry & Biochemistry, University of Missouri St. Louis, St. Louis, MO, 63121, USA. Electronic address:

PA1 (dIm-PyPyβPyPyPy-γ-PyPyβPyPyPyPyβ-Ta) is a large (14-ring) hairpin polyamide that was designed to recognize the DNA sequence 5'-WGW-3', where W is either A or T. As is common among the smaller 6-8-ring hairpin polyamides (PAs), it binds its target recognition sequence with low nM affinity. However, in addition to its large size, it is distinct from these more extensively characterized PAs in its high tolerance for mismatches and antiviral properties. Read More

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November 2018
6 Reads
2.960 Impact Factor

Contribution of microRNAs to the immunosuppressive function of mesenchymal stem cells.

Biochimie 2018 Dec 6;155:109-118. Epub 2018 Jul 6.

IRMB, University Montpellier, INSERM, CHU Montpellier, Montpellier, France; Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital, Montpellier, France. Electronic address:

Mesenchymal stem/stromal cells (MSCs) are progenitor cells identified in many adult tissues, in particular in bone marrow or adipose tissue and, in placental tissues. MSCs exert pleiotropic functions that render them attractive for many clinical applications, both in degenerative and inflammatory diseases. Their main mode of action is through the secretion of trophic factors that can be released in the extracellular milieu or packaged within extracellular vesicles. Read More

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December 2018

Biological applications of tethered bilayer lipid membranes.

Biochimie 2018 Nov 22;157:131-141. Epub 2018 Nov 22.

Institute of Biochemistry, Life Science Center, Vilnius University, Vilnius, LT-10257, Lithuania. Electronic address:

Lipid membranes have an essential role in most physiological processes including cell protection, cell-to-cell communication and regulation of intracellular signaling. These multiple roles of biological membranes prompted the study and the development of artificial lipid membranes with the primary aim to reconstitute the natural functions in vitro and understand the interaction between all membrane components at the molecular level. Tethered bilayer lipid membranes (tBLMs) are emerging as the ideal experimental platform for functional and structural studies on membrane-associated proteins due to their peculiar properties such as their stability and fluidity of both leaflets in the phospholipid bilayer. Read More

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November 2018

Properties of a recombinant GH49 family dextranase heterologously expressed in two recipient strains of Penicillium species.

Biochimie 2018 Nov 23;157:123-130. Epub 2018 Nov 23.

Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Leninsky Pr. 33/2, Moscow, 119071, Russia; Department of Chemistry, M. V. Lomonosov Moscow State University, Vorobyovy Gory 1/11, Moscow, 119991, Russia.

The dexA gene encoding Penicillium funiculosum dextranase (GenBank accession MH581385) belonging to family 49 of glycoside hydrolases (GH49) was cloned and heterologously expressed in two recipient strains, P. canescens RN3-11-7 and P. verruculosum B1-537. Read More

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November 2018

Could glucagon-like peptide-1 be a potential biomarker of early-stage intestinal ischemia?

Biochimie 2018 Nov 14. Epub 2018 Nov 14.

INSERM LNC UMR1231, LIPNESS Team, 7 boulevard Jeanne d'Arc, 21000, Dijon, France; University Bourgogne Franche-Comté, UFR Sciences de Santé, 7 boulevard Jeanne d'Arc, 21000, Dijon, France; LipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne Franche-Comté, 7 boulevard Jeanne d'Arc, 21000, Dijon, France; Agrosup Dijon, 26 boulevard Docteur Petitjean, 21000, Dijon, France. Electronic address:

Intestinal ischemia, also called mesenteric ischemia, is a severe gastrointestinal and vascular medical emergency caused by a sudden decrease of blood flow through the mesenteric vessels. It generates hypoperfusion of intestinal tissues and can rapidly progress to intestinal wall infarction, systemic inflammation or even death if not treated in time. The mortality of this condition is still considerably high despite all the medical advances of the past few years. Read More

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November 2018
2 Reads

Study of the metabolomic relationship between lung cancer and chronic obstructive pulmonary disease based on direct infusion mass spectrometry.

Biochimie 2018 Nov 13;157:111-122. Epub 2018 Nov 13.

Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, Research Center on Health and Environment (RENSMA), 21007, Huelva, Spain. Electronic address:

The high prevalence of lung cancer (LC) has triggered the search of biomarkers for early diagnosis of this disease. For this purpose the study of metabolic changes related to the development of lung cancer could provide interesting information about its early diagnosis. In this sense, chronic obstructive pulmonary disease (COPD), a disease associated with tumor development, is a comorbidity that increases the risk of onset and progression of lung neoplasia and has also to be considered in the study of pathology related to lung cancer. Read More

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November 2018
7 Reads

Neotuberostemonine inhibits osteoclastogenesis via blockade of NF-κB pathway.

Biochimie 2018 Nov 13;157:81-91. Epub 2018 Nov 13.

College of Pharmacy, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu, 704-701, Republic of Korea. Electronic address:

Osteoporosis has been attributed to low bone mass arising from cellular communications between bone formation and bone resorption. Osteoclastogenesis is induced by M-CSF and RANKL in hematopoietic lineage cells. Once RANK/RANKL complex is formed, TRAF6 is recruited and triggers the activation of NF-κB pathway and the expression of osteoclast-related genes including NFATc1. Read More

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November 2018
4 Reads

A novel uORF-based regulatory mechanism controls translation of the human MDM2 and eIF2D mRNAs during stress.

Biochimie 2018 Nov 9;157:92-101. Epub 2018 Nov 9.

School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119234, Russia; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119234, Russia; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia; Department of Biochemistry, Biological Faculty, Lomonosov Moscow State University, Moscow, 119991, Russia. Electronic address:

Short upstream open reading frames (uORFs) are the most prevalent cis-acting regulatory elements in the mammalian transcriptome which can orchestrate mRNA translation. Apart from being "passive roadblocks" that decrease expression of the main coding regions, particular uORFs can serve as specific sensors for changing conditions, thus regulating translation in response to cell stress. Here we report a novel uORF-based regulatory mechanism that is employed under conditions of hyperosmotic stress by at least two human mRNAs, coding for translation reinitiation/recycling factor eIF2D and E3 ubiquitin ligase MDM2. Read More

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November 2018
7 Reads

The cell secretome in personalized and regenerative medicine.

Biochimie 2018 Dec 9;155. Epub 2018 Nov 9.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.

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December 2018

Serotonin in retina.

Authors:
Justine Masson

Biochimie 2018 Nov 9. Epub 2018 Nov 9.

Institut du Fer à Moulin, UMRS 839, INSERM, Sorbonne Université, 75005, Paris, France. Electronic address:

The expression of serotonin (5-HT) in the retina was first reported in the sixties. The detection of vesicular monoamine transporter and serotonin receptors in several retinal cells confirm that 5-HT is playing a neuromodulatory role in this structure. Whereas signaling pathways activated by 5-HT receptor binding has been poorly investigated so far, numerous data demonstrated that 5-HT is involved in retinal physiology, retinal physiopathology and photoreceptor survival. Read More

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November 2018
5 Reads

Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives.

Biochimie 2018 Nov 8;157:64-71. Epub 2018 Nov 8.

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating mutations in a tumor suppressor gene, adenomatous polyposis coli (APC), leading to constitutive activation of the Wnt signaling pathway. This review summarizes the roles of somatic and germline mutations of the APC gene in hereditary as well as sporadic forms of CRC. Read More

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November 2018
8 Reads

A secondary structure within a human piRNA modulates its functionality.

Biochimie 2018 Nov 8;157:72-80. Epub 2018 Nov 8.

Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA. Electronic address:

The piwi-interacting RNAs (piRNAs) are small non-coding RNAs, mostly 24-32 nucleotides in length. The piRNAs are not known to have any conserved secondary structure or sequence motifs. Using bioinformatics analysis, we discovered the presence of putative G-quadruplex (GQ) forming sequences in human piRNAs. Read More

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November 2018
6 Reads

Virus-like nanoparticles as a novel delivery tool in gene therapy.

Biochimie 2018 Nov 5;157:38-47. Epub 2018 Nov 5.

Chemical Engineering Department, University of Tennessee, Chattanooga, TN, 37403, United States.

Viruses are considered as natural nanomaterials as they are in the size range of 20-500 nm with a genetical material either DNA or RNA, which is surrounded by a protein coat capsid. Recently, the field of virus nanotechnology is gaining significant attention from researchers. Attention is given to the utilization of viruses as nanomaterials for medical, biotechnology and energy applications. Read More

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November 2018
18 Reads

Silencing of LncRNA steroid receptor RNA activator attenuates polycystic ovary syndrome in mice.

Biochimie 2018 Nov 1;157:48-56. Epub 2018 Nov 1.

Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, People's Republic of China. Electronic address:

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and has a prevalence of 1 in 15 women worldwide. This study aims to investigate the role of lncRNA SRA in the pathological processes of polycystic ovary syndrome (PCOS).

Methods: Twenty five-day old female C57BL/6 mice received subcutaneous injection of 60 mg/kg dehydroepiandrosterone for 20 days to induce PCOS. Read More

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November 2018
4 Reads
2.960 Impact Factor

Cytotoxic action of acetate on tumor cells of thymic origin: Role of MCT-1, pH homeostasis and altered cell survival regulation.

Biochimie 2018 Nov 1;157:1-9. Epub 2018 Nov 1.

School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India. Electronic address:

Neoplastic cells display altered biosynthetic and bioenergetic machinery to support cell survival. Therefore, cancer cells optimally utilize all available fuel resources to pump their highly upregulated metabolic pathways. While glucose is the main carbon source, transformed cells also utilize other molecules, which can be utilized in metabolic pathways, designated as alternative fuels. Read More

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November 2018
2 Reads

Thermal denaturation profile: A straightforward signature to characterize parallel G-quadruplexes.

Biochimie 2018 Oct 31;157:22-25. Epub 2018 Oct 31.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, China. Electronic address:

G-quadruplexes (G4s) are fascinating non-canonical nucleic acid structures that attract broad attention due to their vital roles in gene expression and various applications. G4s exhibit high structural polymorphism and high resolution techniques (NMR, Crystallography) are often required to unambiguously determine G4 topology. Fast and handy techniques such as UV and CD provide interesting structural information. Read More

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October 2018
1 Read

Mo-CBP-PepI, Mo-CBP-PepII, and Mo-CBP-PepIII are synthetic antimicrobial peptides active against human pathogens by stimulating ROS generation and increasing plasma membrane permeability.

Biochimie 2018 Oct 31;157:10-21. Epub 2018 Oct 31.

Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza, Ceara, 60451, Brazil.

The efficiency of current antimicrobial drugs is noticeably decreasing and thus the development of new treatments is necessary. Natural and synthetic antimicrobial peptides (AMPs) have attracted great attention as promising candidates. Inspired on Mo-CBP, an antimicrobial protein from Moringa oleifera seeds, we designed and synthesized three AMPs named Mo-CBP-PepI, Mo-CBP-PepII, and Mo-CBP-PepIII. Read More

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October 2018
4 Reads

Autoantibody against arrestin-1 as a potential biomarker of renal cell carcinoma.

Biochimie 2018 Oct 30;157:26-37. Epub 2018 Oct 30.

Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia; Department of Cell Signalling, Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia. Electronic address:

Renal cell carcinoma (RCC) is the second-most common uronephrological cancer. In the absence of specific symptoms, early diagnosis of RCC is challenging. Monitoring of the aberrant expression of tumour-associated antigens (TAAs) and related autoantibody response is considered as a novel approach of RCC diagnostics. Read More

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October 2018
3 Reads

Subatomic structure of hyper-sweet thaumatin D21N mutant reveals the importance of flexible conformations for enhanced sweetness.

Biochimie 2018 Oct 31;157:57-63. Epub 2018 Oct 31.

Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto, 611-0011, Japan.

One of the sweetest proteins found in tropical fruits (with a threshold of 50 nM), thaumatin, is also used commercially as a sweetener. Our previous study successfully produced the sweetest thaumatin mutant (D21N), designated hyper-sweet thaumatin, which decreases the sweetness threshold to 31 nM. To investigate why the D21N mutant is sweeter than wild-type thaumatin, we compared the structure of the D21N mutant solved at a subatomic resolution of 0. Read More

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October 2018
2 Reads

3D structure of the natural tetrameric form of human butyrylcholinesterase as revealed by cryoEM, SAXS and MD.

Biochimie 2018 Oct 29;156:196-205. Epub 2018 Oct 29.

National Research Center, Kurchatov Institute, Akademika Kurchatova pl. 1, Moscow, 123182, Russia; Shubnikov Institute of Crystallography of Federal Scientific Research Centre "Crystallography and Photonics" Russian Academy of Sciences, Leninsky pr. 59, Moscow, 119333, Russia.

Human plasma butyrylcholinesterase (BChE) is an endogenous bioscavenger that hydrolyzes numerous medicamentous and poisonous esters and scavenges potent organophosphorus nerve agents. BChE is thus a marker for the diagnosis of OP poisoning. It is also considered a therapeutic target against Alzheimer's disease. Read More

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October 2018
2 Reads

Secretome proteins regulate comparative osteogenic and adipogenic potential in bone marrow and dental stem cells.

Biochimie 2018 Dec 24;155:129-139. Epub 2018 Oct 24.

Department of Biophysics, PGIMER, Chandigarh, India. Electronic address:

Introduction: Dental stem cells (DMSC) have been studied extensively since their early discovery. However, the data regarding osteogenic potential of DMSC with other cell types is sparse and the secretome proteins underlying these differences have not been explored. In this study, we have compared the osteogenic and adipogenic potential of DMSC with Bone Marrow Stem cells (BMSC) and reported the contribution of secretome proteins in controlling their differentiation. Read More

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December 2018
3 Reads
2.963 Impact Factor

Bacterial ribosome heterogeneity: Changes in ribosomal protein composition during transition into stationary growth phase.

Biochimie 2018 Oct 23;156:169-180. Epub 2018 Oct 23.

Institute of Molecular and Cell Biology, University of Tartu, Riia 23B, Tartu, 51010, Estonia. Electronic address:

Ribosomes consist of many small proteins and few large RNA molecules. Both components are necessary for ribosome functioning during translation. According to widely accepted view, bacterial ribosomes contain always the same complement of ribosomal proteins. Read More

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October 2018
14 Reads

Neuroprotective effects of Tat-ATOX1 protein against MPP-induced SH-SY5Y cell deaths and in MPTP-induced mouse model of Parkinson's disease.

Biochimie 2018 Oct 21;156:158-168. Epub 2018 Oct 21.

Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, 24252, South Korea. Electronic address:

Parkinson's disease (PD), a neurodegenerative disorder, is characterized by a loss of dopaminergic neurons in the substantia nigra (SN) of the brain and it is well known that the pathogenesis of PD is related to a number of risk factors including oxidative stress. Antioxidant 1 (ATOX1) protein plays a crucial role in various diseases as an antioxidant and chaperone. In this study, we determined whether Tat-ATOX1 could protect against 1-methyl-4-phenylpyridinium ion (MPP)-induced SH-SY5Y cell death and in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal model of PD. Read More

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October 2018
4 Reads

LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis.

Biochimie 2018 Oct 19;157:102-110. Epub 2018 Oct 19.

Department of Traditional Chinese Medicine, Renmin Hospital of Wuhan University, Wuhan, China.

This study is designed to explore the mechanism by which long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) plays a pathogenic role in uric acid nephropathy (UAN). The expressions of ANRIL, miR-122-5p, BRCA1-BRCA2-containing complex subunit 3 (BRCC3) and NOD-like receptor protein 3 (NLRP3) were determined in UAN patients and uric acid-treated HK-2 cells by qRT-PCR. Protein levels of BRCC3 and NLRP3 were examined by western blot. Read More

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October 2018
9 Reads

High altitude mediated skeletal muscle atrophy: Protective role of curcumin.

Biochimie 2018 Oct 19;156:138-147. Epub 2018 Oct 19.

Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India. Electronic address:

Chronic hypobaric hypoxia induced muscle atrophy results in decreased physical performance at high altitude. Curcumin has been shown to have muscle sparing effects under cachectic conditions. However, the protective effects of curcumin under chronic hypobaric hypoxia have not been studied till now. Read More

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October 2018
12 Reads
2.960 Impact Factor

Epigenetics in the early divergent eukaryotic Giardia duodenalis: An update.

Biochimie 2018 Oct 19;156:123-128. Epub 2018 Oct 19.

Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico City, Mexico. Electronic address:

Giardia duodenalis is a flagellated unicellular eukaryotic microorganism that usually parasitizes the small intestine of humans and many other vertebrates causing diarrheal disease throughout the world. Notably, Giardia despite minimization of most cellular systems shows different strategies to adapt to environmental conditions, evade the immune system and resist exposure to antimicrobial agents. Over the past years, epigenetic regulation of gene expression has been shown to have a relevant role in the parasite's biology. Read More

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October 2018
5 Reads

Influence of passage number on the impact of the secretome of adipose tissue stem cells on neural survival, neurodifferentiation and axonal growth.

Biochimie 2018 Dec 17;155:119-128. Epub 2018 Oct 17.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's - PT Government Associated Laboratory, Braga/Guimarães, Portugal. Electronic address:

Mesenchymal stem cells (MSCs), and within them adipose tissue derived stem cells (ASCs), have been shown to have therapeutic effects on central nervous system (CNS) cell populations. Such effects have been mostly attributed to soluble factors, as well as vesicles, present in their secretome. Yet, little is known about the impact that MSC passaging might have in the secretion therapeutic profile. Read More

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December 2018
1 Read

Ferrochelatase activity of plant frataxin.

Biochimie 2018 Oct 18;156:118-122. Epub 2018 Oct 18.

Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI-CONICET), Universidad Nacional de Rosario, Rosario 2000, Argentina. Electronic address:

Frataxin plays a key role in cellular iron homeostasis of different organisms. It is engaged in several activities at the FeS cluster assembly machinery and it is also involved in heme biosynthesis. In plants, two genes encoding ferrochelatases (FC1 and FC2) catalyze the incorporation of iron into protoporphyrin IX in the last stage of heme synthesis in chloroplasts. Read More

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October 2018
5 Reads

Self-association and folding in membrane determine the mode of action of peptides from the lytic segment of sticholysins.

Biochimie 2018 Oct 13;156:109-117. Epub 2018 Oct 13.

Center for Protein Studies, Biology Faculty, University of Havana, Havana, Cuba. Electronic address:

Sticholysin I and II (Sts: St I and St II) are proteins of biomedical interest that form pores upon the insertion of their N-terminus in the plasma membrane. Peptides spanning the N-terminal residues of StI (StI) or StII (StII) can mimic the permeabilizing ability of these toxins, emerging as candidates to rationalize their potential biomedical applications. These peptides have different activities that correlate with their hydrophobicity. Read More

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October 2018
5 Reads

Activation of catalase via co-administration of aspirin and pioglitazone: Experimental and MLSD simulation approaches.

Biochimie 2018 Oct 14;156:100-108. Epub 2018 Oct 14.

Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran; Center of Excellence in Biothermodynamics, University of Tehran, Tehran, Iran.

Aspirin (ASP) and pioglitazone (PGL) are the most common drugs that are widely used by diabetic patients to control the blood sugar and hinder cardiovascular diseases. The interaction between PGL and ASP is one of the important medical issues to clarify the safety of co-administration of these drugs. In the present study, the effect of co-administered ASP with PGL was investigated on the structure and catalytic function of catalase as a potential target in the liver. Read More

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October 2018
4 Reads

Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy.

Biochimie 2018 Oct 13;156:148-157. Epub 2018 Oct 13.

Department of Animal Sciences, Central University of Punjab, Bathinda, Punjab, India. Electronic address:

The five-year survival rate of esophageal cancer patients is less than 20%. This may be due to increased resistance (acquired or intrinsic) of tumor cells to chemo/radiotherapies, often caused by aberrant cell cycle, deregulated apoptosis, increases in growth factor signaling pathways, and/or changes in the proteome network. In addition, deregulation in non-coding RNA-mediated signaling pathways may contribute to resistance to therapies. Read More

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October 2018
4 Reads

Lysines residing in putative Small Ubiquitin-like MOdifier (SUMO) motifs regulate fate and function of 37 KDa laminin receptor.

Biochimie 2018 Oct 10;156:92-99. Epub 2018 Oct 10.

Purdue University, Department of Basic Medical Sciences, 625 Harrison St, LYNN 2177, West Lafayette, IN, 47907, USA. Electronic address:

There is a putative precursor to mature receptor relationship between 37 Laminin Receptor (LR) and 67 LR. As such, the pair are frequently referred to as a single entity, the 37/67 kDa Laminin Receptor (37/67 LR) and 67 LR was identified as a laminin binding entity. 37/67 LR has been of clinical interest for many years, as 37/67 LR is a prognostic indicator for many cancers including breast, lung, colon, and prostate. Read More

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October 2018
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Fragmentation of Escherichia coli mRNA by MazF and MqsR.

Biochimie 2018 Oct 10;156:79-91. Epub 2018 Oct 10.

Institute of Technology, University of Tartu, Nooruse 1, 50411, Tartu, Estonia. Electronic address:

MazEF and MqsRA are toxin-antitoxin systems, where the toxins MazF and MqsR sequence-specifically cleave single-stranded RNA, thereby shutting down protein synthesis and cell growth. However, it has been proposed that MazF functions in a highly specific pathway, where it truncates the 5' ends of a set of E. coli transcripts (the MazF regulon), which are then translated under stress conditions by specialized ribosomes. Read More

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October 2018
3 Reads

α-Lipoic acid and amlodipine/perindopril combination potentiate the therapeutic effect of mesenchymal stem cells on isoproterenol induced cardiac injury in rats.

Biochimie 2018 Oct 8;156:59-68. Epub 2018 Oct 8.

Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Cardiac injury is a dangerous disease and become a greater issue in the forthcoming decades. The ultimate goal is to prevent the progression of heart failure and apoptotic processes. Cardiac tissue may regenerate itself but to certain extent depending on the number of resident stem cells that is limited. Read More

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October 2018
1 Read

MiR-650 regulates the proliferation, migration and invasion of human oral cancer by targeting growth factor independent 1 (Gfi1).

Biochimie 2018 Oct 6;156:69-78. Epub 2018 Oct 6.

Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, 117 Nanjing North Street, Shenyang, 110002, Liaoning, China. Electronic address:

Oral cancer being one of the lethal cancers is generally detected at advanced stages and causes significant mortality world over. The unavailability of the reliable biomarkers and therapeutic targets/agents forms a bottleneck in the treatment of oral cancer. MicroRNAs are considered of immense therapeutic potential for the treatment of cancer. Read More

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October 2018
7 Reads

Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti-inflammatory and anti-senescent heat shock response in mice.

Biochimie 2018 Sep 28;156:33-46. Epub 2018 Sep 28.

Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address:

Unhealthy lifestyle persistently feeds forward inflammation in metabolic organs thus imposing senescence-associated secretory phenotype (SASP), as observed in obesity and type 2 diabetes. However, SASP blocks physiological resolution of inflammation by suppressing the anti-inflammatory and anti-senescent heat shock (HS) response, i.e. Read More

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September 2018
9 Reads

Pro-inflammatory effects of extracellular Hsp70 and cigarette smoke in primary airway epithelial cells from COPD patients.

Biochimie 2018 Sep 27;156:47-58. Epub 2018 Sep 27.

University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Hematology, Zagreb, Croatia. Electronic address:

Extracellular Hsp70 (eHsp70) can activate immune cells via Toll-like receptors (TLR) 2 and 4, and induce cytokine synthesis. The aim of this study was to explore inflammation-associated effects of eHsp70 alone and in combination with cigarette smoke extract (CSE) in primary bronchial epithelial cells. We assessed IL-6 and IL-8 concentrations, TLR2, TLR4 and Hsp70 mRNA expressions, and mitogen-activated protein kinases (MAPKs) activation induced by recombinant human (rh) Hsp70, CSE or their combinations in normal human bronchial epithelial cells (NHBE) obtained commercially, and primary bronchial epithelial cells isolated from non-COPD lung donors (PBEC) or COPD patients (PBEC COPD). Read More

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September 2018
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Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.

Biochimie 2018 Oct 7;153:203-209. Epub 2018 Jul 7.

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan. Electronic address:

Although 24(S)-hydroxycholesterol (24S-OHC) plays an important role to maintain homeostasis of cholesterol in the brain, it induces neuronal cell death at high concentrations. 24S-OHC-induced cell death was suppressed by γ-tocopherol (γ-Toc) but not by γ-tocotrienol (γ-Toc3) in a similar way to α-tocopherol (α-Toc) and α-tocotrienol (α-Toc3) in human neuroblastoma SH-SY5Y cells. Both γ-Toc and γ-Toc3 significantly inhibited cumene hydroperoxide-induced cell death, as previously shown in the case of α-Toc and α-Toc3. Read More

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October 2018

Thermodynamics of the fourU RNA thermal switch derived from molecular dynamics simulations and spectroscopic techniques.

Biochimie 2018 Sep 19;156:22-32. Epub 2018 Sep 19.

Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland. Electronic address:

Bacterial 5' untranslated regions of mRNA, termed thermal switches or thermometers, change their structure in response to temperature change. This structural change provides for the regulation of gene expression. One of such thermal switches, called fourU, is present in the Salmonella species. Read More

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September 2018
1 Read