164 results match your criteria Biochimica et biophysica acta. Reviews on cancer[Journal]


The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer.

Biochim Biophys Acta Rev Cancer 2019 Apr 11. Epub 2019 Apr 11.

Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA. Electronic address:

Disparate occurrence of breast cancer remains an intriguing question since only a subset of women with known risk factors develop cancer. Recent studies suggest an active role of local and distant microbiota in breast cancer initiation, progression, and overall prognosis. A dysbiotic microbiota predisposes the body to develop cancer by inducing genetic instability, initiating DNA damage and proliferation of the damaged progeny, eliciting favorable immune response, metabolic dysregulation and altered response to therapy. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.04.001DOI Listing
April 2019
1 Read

Atomic force microscopy-based cancer diagnosis by detecting cancer-specific biomolecules and cells.

Biochim Biophys Acta Rev Cancer 2019 Apr 2;1871(2):367-378. Epub 2019 Apr 2.

Biomechanics Laboratory, College of Sport Science, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea. Electronic address:

Atomic force microscopy (AFM) has recently attracted much attention due to its ability to analyze biomolecular interactions and to detect certain biomolecules, which play a crucial role in disease expression. Despite recent studies reporting AFM imaging for the analyses of biomolecules, the application of AFM-based cancer-specific biomolecule/cell detection has remained largely underexplored, especially for the early diagnosis of cancer. In this paper, we review the recent attempts, including our efforts, to analyze and detect cancer-specific biomolecules and cancer cells. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.03.002DOI Listing

Targeting the mTOR regulatory network in hepatocellular carcinoma: Are we making headway?

Biochim Biophys Acta Rev Cancer 2019 Apr 2;1871(2):379-391. Epub 2019 Apr 2.

Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China; Department of Medical Microbiology, Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, China. Electronic address:

The mechanistic target of rapamycin (mTOR) pathway coordinates organismal growth and homeostasis in response to growth factors, nutrients, and cellular energy stage. The pathway regulates several major cellular processes and is implicated in various pathological conditions, including hepatocellular carcinoma (HCC). This review summarizes recent advances of the mTOR pathway, highlights the potential of the mTOR pathway as a therapeutic target, and explores clinical trials targeting the mTOR pathway in HCC. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.03.001DOI Listing
April 2019
2 Reads

Targeting PI3K signaling in cancer: Challenges and advances.

Biochim Biophys Acta Rev Cancer 2019 Apr 1;1871(2):361-366. Epub 2019 Apr 1.

Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address:

The key role of phosphoinositide 3-kinase (PI3K) pathway in different cellular processes and several disorders, together with the presence of targetable proteins, opened the way to promising studies for the development of small molecule inhibitors. Despite the high expectation, the shift of PI3K inhibitors to the clinic met several limitations due to the emergence of dose-limiting, on-target adverse effects. In this review, we will summarize the main issues and recent advances in PI3K inhibitors clinical trials. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.03.003DOI Listing
April 2019
1 Read
7.845 Impact Factor

Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression.

Biochim Biophys Acta Rev Cancer 2019 Feb 28;1871(2):331-341. Epub 2019 Feb 28.

Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, China; School of Life Science, Shanxi University, Taiyuan 030006, China. Electronic address:

Rewiring glucose metabolism, termed as Warburg effect or aerobic glycolysis, is a common signature of cancer cells to meet their high energetic and biosynthetic demands of rapid growth and proliferation. Pyruvate kinase M2 isoform (PKM2) is a key player in such metabolic reshuffle, which functions as a rate-limiting glycolytic enzyme in the cytosol of highly-proliferative cancer cells. During the recent decades, PKM2 has been extensively studied in non-canonical localizations such as nucleus, mitochondria, and extracellular secretion, and pertained to novel biological functions in tumor progression. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.02.003DOI Listing
February 2019

Rethinking pulmonary toxicity in advanced non-small cell lung cancer in the era of combining anti-PD-1/PD-L1 therapy with thoracic radiotherapy.

Biochim Biophys Acta Rev Cancer 2019 Feb 28;1871(2):323-330. Epub 2019 Feb 28.

Department of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

The combination of programmed cell death 1/programmed cell death ligand 1 blockade and thoracic radiotherapy has become the new standard of care in the treatment of locally advanced non-small-cell lung cancer. The information regarding the pulmonary safety of such therapy remains limited to mostly retrospective studies and case reports with a small portion of data from prospective clinical trials. By analyzing the underlying mechanisms of interactions between radiation and immunotherapy from preclinical data and summarizing safety data from relevant clinical studies with pulmonary toxicity, we believe that longer and rigorous follow-up is warranted, to determine if the combination of such modalities is appropriate for patients without risking undue toxicity. Read More

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February 2019
9 Reads

Many ways to resistance: How melanoma cells evade targeted therapies.

Biochim Biophys Acta Rev Cancer 2019 Feb 15;1871(2):313-322. Epub 2019 Feb 15.

Life Sciences Research Unit, University of Luxembourg, 6, avenue du Swing, L-4367 Belvaux, Luxembourg. Electronic address:

Melanoma is an aggressive malignancy originating from pigment-producing melanocytes. The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies (immune checkpoint inhibitors) led to a substantial improvement in overall survival of patients. However, the long-term efficacy of such treatments is limited by side effects, lack of clinical effects and the rapidly emerging resistance to treatment. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.02.002DOI Listing
February 2019

RLIP: An existential requirement for breast carcinogenesis.

Biochim Biophys Acta Rev Cancer 2019 Feb 13;1871(2):281-288. Epub 2019 Feb 13.

Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Breast cancer (BC) is the most common cancer among women worldwide. Due to its complexity in nature, effective BC treatment can encounter many challenges. The human RALBP1 gene encodes a 76-kDa splice variant protein, RLIP (ral-binding protein1, RalBP1), a stress-protective mercapturic acid pathway (MAP) transporter protein, that also plays a key role in regulating clathrin-dependent endocytosis (CDE) as a Ral effector. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.02.001DOI Listing
February 2019
2 Reads

Recent advances in extracellular vesicle research for urological cancers: From technology to application.

Biochim Biophys Acta Rev Cancer 2019 Feb 7;1871(2):342-360. Epub 2019 Feb 7.

The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Urological malignancies, including prostate cancer, bladder cancer and kidney cancer, are major causes of morbidity and mortality worldwide. Because of the high incidence, diversity in biology, and especially direct interaction with urine, urological cancers are an important resource for both scientists and clinicians for novel diagnostic and therapeutic discovery. Extracellular vesicles (EVs) are lipid bilayer encapsulated particles released by cells into the extracellular space. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.01.008DOI Listing
February 2019
4 Reads

Reflections on depletion of tumor stroma in pancreatic cancer.

Biochim Biophys Acta Rev Cancer 2019 Feb 6;1871(2):267-272. Epub 2019 Feb 6.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China. Electronic address:

Pancreatic cancer characteristically has an extremely dense stroma, which facilitates chemoresistance by creating physical and biological barriers to therapeutic agents. Thus, stroma-depleting agents may enhance the delivery and efficacy of chemotherapy drugs. However, stroma-targeting therapy for pancreatic cancer is a double-edged sword, as the stroma can also inhibit tumor metastasis and malignancy. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.01.007DOI Listing
February 2019

The role of necroptosis in cancer: A double-edged sword?

Biochim Biophys Acta Rev Cancer 2019 Feb 1;1871(2):259-266. Epub 2019 Feb 1.

National Center for Liver Cancer, Shanghai, China; The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. Electronic address:

Necroptosis is a programmed, caspase-independent cell death that is morphologically similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by releasing damage-associated molecular patterns. Recent studies suggest that tumor undergoes necroptosis in vivo and necroptosis has pro- or anti-tumoral effects in cancer development and progression. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.01.006DOI Listing
February 2019

Prostate cancer-specific hallmarks of amino acids metabolism: Towards a paradigm of precision medicine.

Biochim Biophys Acta Rev Cancer 2019 Jan 29;1871(2):248-258. Epub 2019 Jan 29.

Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00 Brno, Czech Republic. Electronic address:

So far multiple differences in prostate cancer-specific amino acids metabolism have been discovered. Moreover, attempts to utilize these alterations for prostate cancer diagnosis and treatment have been made. The prostate cancer metabolism and biosynthesis of amino acids are particularly focused on anaplerosis more than on energy production. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.01.001DOI Listing
January 2019
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Targeting acidity in cancer and diabetes.

Biochim Biophys Acta Rev Cancer 2019 Jan 30;1871(2):273-280. Epub 2019 Jan 30.

Dept. of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Roma 00161, Italy. Electronic address:

While cancer is commonly described as "a disease of the genes", it is also a disease of metabolism. Indeed, carcinogenesis and malignancy are highly associated with metabolic re-programming, and there is clinical evidence that interrupting a cancer's metabolic program can improve patients' outcomes. Notably, many of the metabolic adaptations observed in cancer are similar to the same perturbations observed in diabetic patients. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.01.003DOI Listing
January 2019
9 Reads

Combination therapies with HSP90 inhibitors against colorectal cancer.

Biochim Biophys Acta Rev Cancer 2019 Jan 30;1871(2):240-247. Epub 2019 Jan 30.

Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Colorectal Cancer Research Centre, Division for Cancer Medicine, Oslo University Hospital, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address:

Oncogene stability and homeostasis mediated by the HSP90 chaperone is a crucial protection trait of cancer cells. Therefore, HSP90 represents an attractive therapeutic target for many cancers, including colorectal cancer. Although monotherapy has limited clinical efficacy, preclinical and early-phase clinical studies indicate improved antitumor activity when HSP90 inhibitors are combined with chemotherapies or targeted agents. Read More

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January 2019
17 Reads

A critical review of the role of MPYK in the Warburg effect.

Biochim Biophys Acta Rev Cancer 2019 Jan 29;1871(2):225-239. Epub 2019 Jan 29.

Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, KS 66160, United States. Electronic address:

It is becoming generally accepted in recent literature that the Warburg effect in cancer depends on inhibition of MPYK, the pyruvate kinase isozyme most commonly expressed in tumors. We remain skeptical. There continues to be a general lack of solid experimental evidence for the underlying idea that a bottle neck in aerobic glycolysis at the level of MPYK results in an expanded pool of glycolytic intermediates (which are thought to serve as building blocks necessary for proliferation and growth of cancer cells). Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.01.004DOI Listing
January 2019
4 Reads

Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases.

Biochim Biophys Acta Rev Cancer 2019 Jan 29;1871(2):289-312. Epub 2019 Jan 29.

Laboratory of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple signalling pathways, including the PI3K, p38/ERK, and JAK pathways, and regulates cell survival and migration. The CXCLs/CXCR2 axis plays a vital role in the tumour microenvironment and in recruiting neutrophils to inflammatory sites. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.01.005DOI Listing
January 2019

The expression of FOXP3 and its role in human cancers.

Biochim Biophys Acta Rev Cancer 2019 Jan 7;1871(1):170-178. Epub 2019 Jan 7.

Department of Surgery, the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China. Electronic address:

FOXP3 is a transcription factor, which belongs to the family of FOX protein. FOXP3 was initially discovered in regulatory T cells and supposed to play a significant role in the process of regulatory T cell differentiation. Increasing evidence has shown that FOXP3 is also expressed in tumor cells. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.12.004DOI Listing
January 2019
3 Reads

Targeting mitosis exit: A brake for cancer cell proliferation.

Biochim Biophys Acta Rev Cancer 2019 Jan 3;1871(1):179-191. Epub 2019 Jan 3.

Tongji School of Pharmacy, Huazhong University of Science & Technology, Wuhan, Hubei 430030, China. Electronic address:

The transition from mitosis to interphase, referred to as mitotic exit, is a critical mitotic process which involves activation and inactivation of multiple mitotic kinases and counteracting protein phosphatases. Loss of mitotic exit checkpoints is a common feature of cancer cells, leading to mitotic dysregulation and confers cancer cells with oncogenic characteristics, such as aberrant proliferation and microtubule-targeting agent (MTA) resistance. Since MTA resistance results from cancer cells prematurely exiting mitosis (mitotic slippage), blocking mitotic exit is believed to be a promising anticancer strategy. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.12.007DOI Listing
January 2019
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Immune checkpoint blockade and its combination therapy with small-molecule inhibitors for cancer treatment.

Biochim Biophys Acta Rev Cancer 2018 Dec 31;1871(2):199-224. Epub 2018 Dec 31.

Laboratory of Aging Research and Nanotoxicology, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan 610041, PR China. Electronic address:

Initially understood for its physiological maintenance of self-tolerance, the immune checkpoint molecule has recently been recognized as a promising anti-cancer target. There has been considerable interest in the biology and the action mechanism of the immune checkpoint therapy, and their incorporation with other therapeutic regimens. Recently the small-molecule inhibitor (SMI) has been identified as an attractive combination partner for immune checkpoint inhibitors (ICIs) and is becoming a novel direction for the field of combination drug design. Read More

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December 2018
18 Reads

Genetic aberrations and alterations in signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer.

Biochim Biophys Acta Rev Cancer 2018 Dec 31. Epub 2018 Dec 31.

Department of Microbiology and Immunology, University of Illinois-College of Medicine, Chicago, IL, USA. Electronic address:

Anaplastic Thyroid Cancer (ATC) accounts for >40% thyroid cancer-related deaths and has a dismal prognosis. In the past decade, significant efforts have been made towards understanding the pathogenesis of this disease and developing novel therapeutics. Unfortunately, effective treatment is still lacking and a more thorough understanding of ATC pathogenesis may provide new opportunities to improve ATC therapeutics. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.12.003DOI Listing
December 2018
7.845 Impact Factor

Modulation of radiation sensitivity and antitumor immunity by viral pathogenic factors: Implications for radio-immunotherapy.

Biochim Biophys Acta Rev Cancer 2019 Jan 31;1871(1):126-137. Epub 2018 Dec 31.

Department of Radiotherapy and Oncology, Goethe-University, Frankfurt am Main, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK) partner site: Frankfurt am Main, Germany.

Several DNA viruses including Human Papillomavirus (HPV), Epstein-Barr virus (EBV), and Human cytomegalovirus (HCMV) are mechanistically associated with the development of human cancers (HPV, EBV) and/or modulation of the immune system (HCMV). Moreover, a number of distinct mechanisms have been described regarding the modulation of tumor cell response to ionizing radiation and evasion from the host immune system by viral factors. There is further accumulating interest in the treatment with immune-modulatory therapies such as immune checkpoint inhibitors for malignancies with a viral etiology. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.12.006DOI Listing
January 2019

The emerging role for Cullin 4 family of E3 ligases in tumorigenesis.

Biochim Biophys Acta Rev Cancer 2019 Jan 30;1871(1):138-159. Epub 2018 Dec 30.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

As a member of the Cullin-RING ligase family, Cullin-RING ligase 4 (CRL4) has drawn much attention due to its broad regulatory roles under physiological and pathological conditions, especially in neoplastic events. Based on evidence from knockout and transgenic mouse models, human clinical data, and biochemical interactions, we summarize the distinct roles of the CRL4 E3 ligase complexes in tumorigenesis, which appears to be tissue- and context-dependent. Notably, targeting CRL4 has recently emerged as a noval anti-cancer strategy, including thalidomide and its derivatives that bind to the substrate recognition receptor cereblon (CRBN), and anticancer sulfonamides that target DCAF15 to suppress the neoplastic proliferation of multiple myeloma and colorectal cancers, respectively. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.11.007DOI Listing
January 2019
3 Reads

Role of mesenchymal stromal cell-derived extracellular vesicles in tumour microenvironment.

Biochim Biophys Acta Rev Cancer 2019 Jan 30;1871(1):192-198. Epub 2018 Dec 30.

Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy. Electronic address:

Stromal cells, deriving from mesenchymal stromal cells (MSCs), are crucial component of tumour microenvironment and represent key regulators of tumour processes. MSCs can be recruited to the tumour environment and interact with many cellular elements, thus influencing tumour biology. Cell-to-cell communication is in part mediated by the release of extracellular vesicle (EVs). Read More

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January 2019

Piwi-interacting RNAs (piRNAs) and cancer: Emerging biological concepts and potential clinical implications.

Biochim Biophys Acta Rev Cancer 2019 Jan 30;1871(1):160-169. Epub 2018 Dec 30.

Center for Gastrointestinal Research, Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute and Charles A Sammons Cancer Center, Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246-2017, USA. Electronic address:

Piwi-interacting RNAs (piRNAs) are a very recently discovered class of small non-coding RNAs (ncRNAs), with approximately 20,000 piRNA genes already identified within the human genome. These short RNAs were originally described as key functional regulators for the germline maintenance and transposon silencing. However, due to our limited knowledge regarding their function, piRNAs were for a long time assumed to be the "dark matter" of ncRNAs in our genome. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392428PMC
January 2019
1 Read

What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer.

Biochim Biophys Acta Rev Cancer 2019 Jan 7;1871(1):109-116. Epub 2018 Dec 7.

Center for Nanomedicine and Theranostics, Department of Micro- and Nanotechnology, Technical University of Denmark, Denmark. Electronic address:

Circulating biomarkers have a great potential in diagnosing cancer diseases at early stages, where curative treatment is a realistic possibility. In the recent years, using extracellular vesicles (EVs) derived from blood as biomarkers has gained widespread popularity, mainly because they are thought to be easy to isolate and carry a vast variety of biological cargos that can be analyzed for biomarker purposes. However, our current knowledge on the plasma EV concentration in normophysiological states is sparse. Read More

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January 2019
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Advancing the understanding of NAFLD to hepatocellular carcinoma development: From experimental models to humans.

Biochim Biophys Acta Rev Cancer 2019 Jan 5;1871(1):117-125. Epub 2018 Dec 5.

College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China; Biomedical Research Center, Northwest Minzu University, Lanzhou, China; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) has recently been recognized as an important etiology contributing to the increased incidence of hepatocellular carcinoma (HCC). NAFLD, characterized by fat accumulation in the liver, is affecting at least one-third of the global population. The more aggressive form, nonalcoholic steatohepatitis (NASH), is characterized by hepatocyte necrosis and inflammation. Read More

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January 2019
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An emerging role for nanomaterials in increasing immunogenicity of cancer cell death.

Biochim Biophys Acta Rev Cancer 2019 Jan 6;1871(1):99-108. Epub 2018 Dec 6.

Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhni Novgorod, Nizhny Novgorod, Russian Federation; Cell Death Investigation and Therapy Laboratory, Department of Human Structure and Repair, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium. Electronic address:

In the last decade, it has become clear that anti-cancer therapy is more successful when it can also induce an immunogenic form of cancer cell death (ICD). ICD is an umbrella term covering several cell death modalities, including apoptosis and necroptosis. In general, ICD is characterized by the emission of damage-associated molecular patterns (DAMPs) and/or cytokines/chemokines, leading to the induction of strong anti-tumor immune responses. Read More

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January 2019
3 Reads

Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies.

Biochim Biophys Acta Rev Cancer 2019 Jan 9;1871(1):85-98. Epub 2018 Nov 9.

Department of Microbiology, Harbin Medical University, Harbin, China; Wu Lien-Teh Institute, Harbin Medical University, Harbin, China; Heilongjiang Province Key Laboratory of Immunity and Infection, Pathogenic Biology, Harbin, China. Electronic address:

The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed in many tumors, and is linked to the regulation of many cancer-related pathways. It co-activates many transcription factors, with profound implications for cancer development, and the de-regulation of its functions is ultimately associated with tumor formation and progression. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.11.003DOI Listing
January 2019
2 Reads
7.845 Impact Factor

NF-kappaB-inducing kinase in cancer.

Biochim Biophys Acta Rev Cancer 2019 Jan 9;1871(1):40-49. Epub 2018 Nov 9.

Institute of Experimental Internal Medicine, Otto von Guericke University, 39120 Magdeburg, Germany. Electronic address:

Dysregulation of the alternative NF-κB signaling has severe developmental consequences that can ultimately lead to oncogenesis. Pivotal for the activation of the alternative NF-κB pathway is the stabilization of the NF-κB-inducing kinase (NIK). The aim of this review is to focus on the emerging role of NIK in cancer. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.10.002DOI Listing
January 2019
15 Reads

The cornerstone of integrating circulating tumor DNA into cancer management.

Biochim Biophys Acta Rev Cancer 2019 Jan 9;1871(1):1-11. Epub 2018 Nov 9.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, People's Republic of China. Electronic address:

Recent circulating tumor DNA (ctDNA) research has demonstrated its potential as a non-invasive biomarker for cancer. However, the deployment of ctDNA assays in routine clinical practice remains challenging owing to variability in analytical approaches and the assessment of clinical significance. A well-developed, analytically valid ctDNA assay is a prerequisite for integrating ctDNA into cancer management, and an appropriate analytical technology is crucial for the development of a ctDNA assay. Read More

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January 2019
1 Read
7.845 Impact Factor

EMT: A mechanism for escape from EGFR-targeted therapy in lung cancer.

Biochim Biophys Acta Rev Cancer 2019 Jan 10;1871(1):29-39. Epub 2018 Nov 10.

Petrov Institute of Oncology, Saint-Petersburg, Russia. Electronic address:

Epithelial mesenchymal transition (EMT) is a reversible developmental genetic programme of transdifferentiation of polarised epithelial cells to mesenchymal cells. In cancer, EMT is an important factor of tumour cell plasticity and has received increasing attention for its role in the resistance to conventional and targeted therapies. In this paper we provide an overview of EMT in human malignancies, and discuss contribution of EMT to the development of the resistance to Epidermal Growth Factor Receptor (EGFR)-targeted therapies in non-small cell lung cancer (NSCLC). Read More

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January 2019
16 Reads

Unraveling the journey of cancer stem cells from origin to metastasis.

Biochim Biophys Acta Rev Cancer 2019 Jan 9;1871(1):50-63. Epub 2018 Nov 9.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA. Electronic address:

Cancer biology research over recent decades has given ample evidence for the existence of self-renewing and drug-resistant populations within heterogeneous tumors, widely recognized as cancer stem cells (CSCs). However, a lack of clear understanding about the origin, existence, maintenance, and metastatic roles of CSCs limit efforts towards the development of CSC-targeted therapy. In this review, we describe novel avenues of current CSC biology. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347501PMC
January 2019
13 Reads

Functions and clinical implications of exosomes in pancreatic cancer.

Biochim Biophys Acta Rev Cancer 2019 Jan 9;1871(1):75-84. Epub 2018 Nov 9.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 2000332, China. Electronic address:

Pancreatic cancer is one of the most aggressive human malignancies and is associated with a dismal prognosis, which can be contributed to its atypical symptoms, metastatic propensity, and significant chemoresistance. Emerging evidence shows that pancreatic cancer cell-derived exosomes (PEXs) play critical roles in tumorigenesis and tumor development, as they are involved in drug resistance, immune evasion and metabolic reprograming, and distant metastasis of pancreatic cancer. Their numerous differentially expressed and functional contents make PEXs promising screening tools and therapeutic targets, which require further exploration. Read More

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January 2019
10 Reads

Role of tumor-derived exosomes in cancer metastasis.

Biochim Biophys Acta Rev Cancer 2019 Jan 9;1871(1):12-19. Epub 2018 Nov 9.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. Electronic address:

The highlights of cancer research include the discovery of exosomes, which are small (30-100 nm) sized vesicular nanoparticles released virtually by all cells. Tumor-derived exosomes (TDEs) are notoriously known for orchestrating the invasion-metastasis cascade via systemic pathways that we have previously proposed (1), resulting in a paradigm shift of our understanding about the pathobiology of metastases. In principle, exosomes serve as transport medium for proteins, mRNAs and miRNAs to transmit targeted cues from the primary cell to distant sites via horizontal transfer or cell-receptor interaction. Read More

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January 2019
43 Reads
7.845 Impact Factor

Neural regulation of drug resistance in cancer treatment.

Biochim Biophys Acta Rev Cancer 2019 Jan 9;1871(1):20-28. Epub 2018 Nov 9.

Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou 221000, Jiangsu, China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou 221000, Jiangsu, China. Electronic address:

The treatment of cancer has made great progress. However, drug resistance remains problematic. Multiple physiologic processes of tumor development can be dominated by central and sympathetic nervous systems. Read More

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January 2019
14 Reads

Dancing from bottoms up - Roles of the POZ-ZF transcription factor Kaiso in Cancer.

Biochim Biophys Acta Rev Cancer 2019 Jan 9;1871(1):64-74. Epub 2018 Nov 9.

Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada. Electronic address:

The POZ-ZF transcription factor Kaiso was discovered two decades ago as a binding partner for p120. Since its discovery, roles for Kaiso in diverse biological processes (epithelial-to-mesenchymal transition, apoptosis, inflammation) and several signalling pathways (Wnt/β-catenin, TGFβ, EGFR, Notch) have emerged. While Kaiso's biological role in normal tissues has yet to be fully elucidated, Kaiso has been increasingly implicated in multiple human cancers including colon, prostate, ovarian, lung, breast and chronic myeloid leukemia. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467064PMC
January 2019
19 Reads

Cancer Metabolism: the Known, Unknowns.

Authors:
Chi Van Dang

Biochim Biophys Acta Rev Cancer 2018 Aug 13;1870(1). Epub 2018 Aug 13.

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August 2018
1 Read

The next generation of PI3K-Akt-mTOR pathway inhibitors in breast cancer cohorts.

Biochim Biophys Acta Rev Cancer 2018 Dec 21;1870(2):185-197. Epub 2018 Aug 21.

Department of Surgery, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address:

The PI3K/Akt/mTOR pathway plays a role in various oncogenic processes in breast cancer and key pathway aberrations have been identified which drive the different molecular subtypes. Early drugs developed targeting this pathway produced some clinical success but were hampered by pharmacokinetics, tolerability and efficacy problems. This created a need for new PI3K pathway-inhibiting drugs, which would produce more robust results allowing incorporation into treatment regimens for breast cancer patients. Read More

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December 2018
15 Reads

Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment.

Biochim Biophys Acta Rev Cancer 2018 Dec 21;1870(2):165-175. Epub 2018 Aug 21.

Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore. Electronic address:

Cells and soluble mediators of the innate and adaptive immune systems are fundamental components of the tumor microenvironment. Nuclear factors, e.g. Read More

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December 2018
9 Reads

Dynamic matrisome: ECM remodeling factors licensing cancer progression and metastasis.

Biochim Biophys Acta Rev Cancer 2018 Dec 12;1870(2):207-228. Epub 2018 Oct 12.

Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, UK.

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process. The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic progression; however, the ECM exists as a complex macromolecular substrate and it is unclear how its molecular composition promotes cancer progression. ECM homeostasis is regulated by various secreted proteins including cross-linkers (e. Read More

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December 2018
15 Reads

PI3K pathway in prostate cancer: All resistant roads lead to PI3K.

Biochim Biophys Acta Rev Cancer 2018 Dec 6;1870(2):198-206. Epub 2018 Oct 6.

Department of Physiology and Biomedical Sciences, Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, South Korea. Electronic address:

The phosphoinositide 3-kinase (PI3K) pathway integrates multifarious environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the PI3K pathway increases biological fitness by offering a high degree of adaptability to and resilience against diverse perturbations, thus conferring survival benefits on premalignant and transformed cells. In prostate cancer, the PI3K pathway is aberrantly activated by various genetic and epigenetic alterations and its hyperactivation is closely associated with a poor clinical outcome. Read More

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December 2018
4 Reads

Mitochondrial dynamics in cancer-induced cachexia.

Biochim Biophys Acta Rev Cancer 2018 Dec 29;1870(2):137-150. Epub 2018 Jul 29.

Division of Human Nutrition, Wageningen University and Research, Wageningen, Netherlands. Electronic address:

Cancer-induced cachexia has a negative impact on quality of life and adversely affects therapeutic outcomes and survival rates. It is characterized by, often severe, loss of muscle, with or without loss of fat mass. Insight in the pathophysiology of this complex metabolic syndrome and direct treatment options are still limited, which creates a research demand. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.07.008DOI Listing
December 2018
17 Reads
7.845 Impact Factor

Glutaminase isoenzymes in the metabolic therapy of cancer.

Biochim Biophys Acta Rev Cancer 2018 Dec 24;1870(2):158-164. Epub 2018 Jul 24.

IBIMA, Department of Molecular Biology and Biochemistry, Faculty of Sciences, Campus de Teatinos, University of Málaga, 29071 Málaga, Spain.

Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with malignancy of tumours. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.07.007DOI Listing
December 2018

ARID1A mutant ovarian clear cell carcinoma: A clear target for synthetic lethal strategies.

Biochim Biophys Acta Rev Cancer 2018 Dec 17;1870(2):176-184. Epub 2018 Jul 17.

Department of Medical Oncology, Cancer Research Centre Groningen, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. Electronic address:

SWI/SNF chromatin remodeling complexes play an important role in the epigenetic regulation of chromatin structure and gene transcription. Mutual exclusive subunits in the SWI/SNF complex include the DNA targeting members ARID1A and ARID1B as well as the ATPases SMARCA2 and SMARCA4. SWI/SNF complexes are mutated across many cancer types. Read More

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December 2018
2 Reads

Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism.

Biochim Biophys Acta Rev Cancer 2018 Aug 6;1870(1):103-121. Epub 2018 Aug 6.

Lady Davis Institute, McGill University, Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montréal, QC H3T 1E2, Canada; Department of Oncology, McGill University, 5100 de Maisonneuve Blvd. West, Suite 720, Montréal H4A 3T2, QC, Canada. Electronic address:

Cancer is irrevocably linked to aberrant metabolic processes. While once considered a vestigial organelle, we now know that peroxisomes play a central role in the metabolism of reactive oxygen species, bile acids, ether phospholipids (e.g. Read More

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August 2018
3 Reads

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors.

Biochim Biophys Acta Rev Cancer 2018 Aug 11;1870(1):15-22. Epub 2018 Jul 11.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

Cancer cells are characterized by high metabolic demand. The substrates in demand include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular metabolism and bioenergetics. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.07.002DOI Listing
August 2018
5 Reads

Extracellular vesicles and anti-cancer drug resistance.

Biochim Biophys Acta Rev Cancer 2018 Dec 10;1870(2):123-136. Epub 2018 Jul 10.

School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address:

Extracellular vesicles (EVs) including exosomes, microvesicles, oncosomes, and microparticles have been associated with communicating anti-cancer drug-resistance. The in vitro, pre-clinical in vivo and patients' data linking EVs to drug-resistance (and the specific drugs involved) in breast cancer, prostate cancer, lung cancer, ovarian cancer, haematological malignancies, colorectal cancer, gastric cancer, pancreatic cancer, glioblastoma, neuroblastoma, melanoma, kidney cancer and osteosarcoma. Details of the mechanisms by which the resistance seems to be occurring (e. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.07.003DOI Listing
December 2018
12 Reads

Hybrid epithelial/mesenchymal phenotype(s): The 'fittest' for metastasis?

Biochim Biophys Acta Rev Cancer 2018 Dec 8;1870(2):151-157. Epub 2018 Jul 8.

Center for Theoretical Biological Physics, Rice University, Houston, TX, USA; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Metastasis is the leading cause of mortality among cancer patients. Dissemination enabled by an epithelial-to-mesenchymal transition (EMT) of carcinoma cells has long been considered to be the predominant mechanism for carcinoma metastasis, based on overexpression studies of many EMT-inducing transcription factors. Individual CTCs - and a binary framework of EMT - have been long considered to be sufficient and necessary condition for metastasis. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.07.001DOI Listing
December 2018
35 Reads

EMT, stemness and tumor plasticity in aggressive variant neuroendocrine prostate cancers.

Biochim Biophys Acta Rev Cancer 2018 Dec 5;1870(2):229-238. Epub 2018 Jul 5.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Stem Cell and Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

Neuroendocrine/Aggressive Variant Prostate Cancers are lethal variants of the disease, with an aggressive clinical course and very short responses to conventional therapy. The age-adjusted incidence rate for this tumor sub-type has steadily increased over the past 20 years in the United States, with no reduction in the associated mortality rate. The molecular networks fueling its emergence and sustenance are still obscure; however, many factors have been associated with the onset and progression of neuroendocrine differentiation in clinically typical adenocarcinomas including loss of androgen-receptor expression and/or signaling, conventional therapy, and dysregulated cytokine function. Read More

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http://dx.doi.org/10.1016/j.bbcan.2018.06.006DOI Listing
December 2018
4 Reads
7.845 Impact Factor

Preclinical models for precision oncology.

Biochim Biophys Acta Rev Cancer 2018 Dec 28;1870(2):239-246. Epub 2018 Jun 28.

Candiolo Cancer Institute-FPO, IRCCS, Candiolo, TO, Italy; Department of Oncology, University of Torino, SP 142 km 3.95, Candiolo, TO, Italy. Electronic address:

Precision medicine approaches have revolutionized oncology. Personalized treatments require not only identification of the driving molecular alterations, but also development of targeted therapies and diagnostic tests to identify the appropriate patient populations for clinical trials and subsequent therapeutic implementation. Preclinical in vitro and in vivo models are widely used to predict efficacy of newly developed treatments. Read More

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December 2018
35 Reads