243 results match your criteria Biochimica et biophysica acta. Reviews on cancer[Journal]


Bacteria as a double-action sword in cancer.

Biochim Biophys Acta Rev Cancer 2020 Jun 23;1874(1):188388. Epub 2020 Jun 23.

Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, SAR, China. Electronic address:

Bacteria have long been known as one of the primary causative agents of cancer, however, recent studies suggest that they can be used as a promising agent in cancer therapy. Because of the limitations that conventional treatment faces due to the specific pathophysiology and the tumor environment, there is a great need for the new anticancer therapeutic agents. Bacteriotherapy utilizes live, attenuated strains or toxins, peptides, bacteriocins of the bacteria in the treatment of cancer. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188388DOI Listing

Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal.

Biochim Biophys Acta Rev Cancer 2020 Jun 21;1874(1):188387. Epub 2020 Jun 21.

The Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA. Electronic address:

Late detection, compromised immune system, and chemotherapy resistance underlie the poor patient prognosis for pancreatic ductal adenocarcinoma (PDAC) patients, making it the 3 leading cause of cancer-related deaths in the United States. Cooperation between the tumor cells and the immune system leads to the immune escape and eventual establishment of the tumor. For more than 20 years, sincere efforts have been made to intercept the tumor-immune crosstalk and identify the probable therapeutic targets for breaking self-tolerance toward tumor antigens. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188387DOI Listing

Immunomodulatory effects of ablation therapy on tumors: Potentials for combination with immunotherapy.

Biochim Biophys Acta Rev Cancer 2020 Jun 15;1874(1):188385. Epub 2020 Jun 15.

Department of Minimally Invasive Therapy Center, Fudan University Shanghai Cancer Center, Shanghai 200032, PR China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, PR China. Electronic address:

As a promising area of tumor treatment, immunotherapies, such as immune checkpoint inhibitors, have been applied to various types of cancer. However, many patients do not respond to such therapies. Increasing application of tumor ablation therapy, a minimally invasive treatment, has been observed in the clinic. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188385DOI Listing

Priming the tumor immune microenvironment with chemo(radio)therapy: A systematic review across tumor types.

Biochim Biophys Acta Rev Cancer 2020 Jun 12;1874(1):188386. Epub 2020 Jun 12.

Amsterdam UMC, University of Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.

Background: Chemotherapy (CT), radiotherapy (RT), and chemoradiotherapy (CRT) are able to alter the composition of the tumor immune microenvironment (TIME). Understanding the effect of these modalities on the TIME could aid in the development of improved treatment strategies. Our aim was to systematically review studies investigating the influence of CT, RT or CRT on different TIME markers. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188386DOI Listing

Cardiovascular risks and toxicity - The Achilles heel of androgen deprivation therapy in prostate cancer patients.

Biochim Biophys Acta Rev Cancer 2020 Jun 11:188383. Epub 2020 Jun 11.

Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University Richmond, VA 23298-0204, USA. Electronic address:

Androgen deprivation therapy (ADT) is the primary systemic therapy for treating locally advanced or metastatic prostate cancer (PCa). Despite its positive effect on PCa patient survival, ADT causes various adverse effects, including increased cardiovascular risk factors and cardiotoxicity. Lifespans extension, early use of ADT, and second-line treatment with next-generation androgen receptor pathway inhibitors would further extend the duration of ADT and possibly increase the risk of ADT-induced cardiotoxicity. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188383DOI Listing
June 2020
7.845 Impact Factor

Killing the "BAD": Challenges for immunotherapy in pancreatic cancer.

Biochim Biophys Acta Rev Cancer 2020 Jun 9;1874(1):188384. Epub 2020 Jun 9.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pancreatic Cancer Institute, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China. Electronic address:

Cancer regression often fails after systemic immune activation, especially for solid tumors due to their local immunosuppressive microenvironments. Among these, the pancreatic cancer microenvironment is unique and an important reason for resistance to anti-cancer treatments that include immunotherapy. In this review, the three main "BAD" characteristics that create and maintain this immunosuppressive microenvironment are discussed for effector T cells: Barriers to overcome, Attraction problems, and their Disabilities. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188384DOI Listing

New insights on sorafenib resistance in liver cancer with correlation of individualized therapy.

Biochim Biophys Acta Rev Cancer 2020 Jun 6;1874(1):188382. Epub 2020 Jun 6.

International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital/Institute, Second Military Medical University, Shanghai 200433, China; National Center for Liver Cancer, Shanghai 200433, China. Electronic address:

Liver cancer is highly malignant and insensitive to cytotoxic chemotherapy and is associated with very poor patient prognosis. In 2007, the small-molecule targeted drug sorafenib was approved for the treatment of advanced liver cancer. In the subsequent ten years, sorafenib has been the only first-line therapeutic targeted drug for advanced hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188382DOI Listing

Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics.

Biochim Biophys Acta Rev Cancer 2020 May 31;1874(1):188381. Epub 2020 May 31.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA. Electronic address:

The United States Food and Drug Administration has permitted number of therapeutic agents for cancer treatment. Most of them are expensive and have some degree of systemic toxicity which makes overbearing in clinical settings. Although advanced research continuously applied in cancer therapeutics, but drug resistance, metastasis, and recurrence remain unanswerable. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188381DOI Listing

Emerging functions and clinical prospects of connexins and pannexins in melanoma.

Biochim Biophys Acta Rev Cancer 2020 May 24;1874(1):188380. Epub 2020 May 24.

CellCOM Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña, Xubias de Arriba, 84, 15006 A Coruña, Spain. Electronic address:

Cellular communication through gap junctions and hemichannels formed by connexins and through channels made by pannexins allows for metabolic cooperation and control of cellular activity and signalling. These channel proteins have been described to be tumour suppressors that regulate features such as cell death, proliferation and differentiation. However, they display cancer type-dependent and stage-dependent functions and may facilitate tumour progression through junctional and non-junctional pathways. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188380DOI Listing

Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions.

Biochim Biophys Acta Rev Cancer 2020 May 18;1874(1):188379. Epub 2020 May 18.

Cell Signaling and Cancer Biology Laboratory, Department of Biochemistry, Guindy Campus, University of Madras, Chennai 600025, India. Electronic address:

Breast cancer is the most ubiquitous type of neoplasms among women worldwide. Molecular aberrations associated with breast development and progressions have been extensively investigated in recent years. An AMP-activated kinase (AMPK) initially identified as a cellular energy sensor that plays a crucial role in cellular energy homeostasis. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188379DOI Listing
May 2020
7.845 Impact Factor

FOX transcription factor family in hepatocellular carcinoma.

Biochim Biophys Acta Rev Cancer 2020 May 11;1874(1):188376. Epub 2020 May 11.

Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process, involving the progressive accumulation of molecular alterations and transcriptomic alterations. The Forkhead-box (FOX) transcription factor family is characterized by its unique DNA binding domain (FKH or winged-helix domain). Human FOX family consists of about 17 subfamilies, at least 43 members. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188376DOI Listing

Nucleic acid nanotechnology for cancer treatment.

Biochim Biophys Acta Rev Cancer 2020 May 11;1874(1):188377. Epub 2020 May 11.

Department of Biomedical Sciences, University of Ulsan College of Medicine, ASAN Medical Center, Seoul 05505, South Korea. Electronic address:

Cancer is one of the most prevalent potentially lethal diseases. With the increase in the number of investigations into the uses of nanotechnology, many nucleic acid (NA)-based nanostructures such as small interfering RNA, microRNA, aptamers, and immune adjuvant NA have been applied to treat cancer. Here, we discuss studies on the applications of NA in cancer treatment, recent research trends, and the limitations and prospects of specific NA-mediated gene therapy and immunotherapy for cancer treatment. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188377DOI Listing

CRISPR screen in mechanism and target discovery for cancer immunotherapy.

Biochim Biophys Acta Rev Cancer 2020 May 13;1874(1):188378. Epub 2020 May 13.

Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou 221000, Jiangsu, China; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou 221000, Jiangsu, China. Electronic address:

CRISPR/Cas-based genetic perturbation screens have emerged as powerful tools for large-scale identification of new targets for cancer immunotherapy. Various strategies of CRISPR screen have been used for immune-oncology (IO) target discovery. The genomic sequences targeted by CRISPR/Cas system range from coding sequences to non-coding RNA/DNA, including miRNAs, LncRNAs, circRNAs, promoters, and enhancers, which may be potential targets for future pharmacological and therapeutic interventions. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188378DOI Listing
May 2020
7.845 Impact Factor

Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges.

Biochim Biophys Acta Rev Cancer 2020 Apr 25;1874(1):188367. Epub 2020 Apr 25.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address:

Pancreatic neuroendocrine neoplasms (PanNENs) contain two primary subtypes with distinct molecular features and associated clinical outcomes: well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). PanNENs are a group of clinically heterogeneous tumors, whose diagnosis is based on tumor morphologic features and proliferation indices. However, these standards incompletely meet clinical needs by failing to adequately assess the likelihood of tumor recurrence and the potential for therapeutic response. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188367DOI Listing

Enzyme-based autophagy in anti-neoplastic management: From molecular mechanisms to clinical therapeutics.

Biochim Biophys Acta Rev Cancer 2020 Apr 24;1874(1):188366. Epub 2020 Apr 24.

Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA; Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

Autophagy is an evolutionarily conserved self-cannibalization process commonly found in all eukaryotic cells. Through autophagy, long-lived or damaged organelles, superfluous proteins, and pathogens are sequestered and encapsulated into the double-membrane autophagosomes prior to fusion with lysosomes for ultimate degradation and recycling. Given that autophagy is deemed both protective and detrimental in malignancies, the clinical therapeutic utilization of autophagy modulators in cancer has attracted immense attentions over the past decades. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188366DOI Listing

Functionally analyzing the important roles of hepatocyte nuclear factor 3 (FoxA) in tumorigenesis.

Biochim Biophys Acta Rev Cancer 2020 04 20;1873(2):188365. Epub 2020 Apr 20.

Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510275, China. Electronic address:

Transcriptional factors (TFs) play a central role in governing gene expression under physiological conditions including the processes of embryonic development, metabolic homeostasis and response to extracellular stimuli. Conceivably, the aberrant dysregulations of TFs would dominantly result in various human disorders including tumorigenesis, diabetes and neurodegenerative diseases. Serving as the most evolutionarily reserved TFs, Fox family TFs have been explored to exert distinct biological functions in neoplastic development, by manipulating diverse gene expression. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188365DOI Listing

Odyssey of trefoil factors in cancer: Diagnostic and therapeutic implications.

Biochim Biophys Acta Rev Cancer 2020 04 13;1873(2):188362. Epub 2020 Apr 13.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, NE, 68198, USA. Electronic address:

Trefoil factors 1, 2, and 3 (TFFs) are a family of small secretory molecules involved in the protection and repair of the gastrointestinal tract (GI). TFFs maintain and restore epithelial structural integrity via transducing key signaling pathways for epithelial cell migration, proliferation, and invasion. In recent years, TFFs have emerged as key players in the pathogenesis of multiple diseases, especially cancer. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188362DOI Listing

The rise of T-type channels in melanoma progression and chemotherapeutic resistance.

Biochim Biophys Acta Rev Cancer 2020 04 7;1873(2):188364. Epub 2020 Apr 7.

Universitat de Lleida-IRBlLeida, Cell Calcium Signaling Lab, 25198, Rovira Roure, 80, Lleida, Spain. Electronic address:

Hyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the BRAF and NRAS genes. MAPK inhibitors are effective only short-term, and recurrence occurs due to functional redundancies or intertwined pathways. The remodeling of Ca signaling is also common in melanoma cells, partly through the increased expression of T-type channels (TTCCs). Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188364DOI Listing

Circulating tumour DNA: A new biomarker to monitor resistance in NSCLC patients treated with EGFR-TKIs.

Biochim Biophys Acta Rev Cancer 2020 04 8;1873(2):188363. Epub 2020 Apr 8.

Peking University Fifth School of Clinical Medicine, National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China; National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China. Electronic address:

Targeted molecular therapies have markedly improved the therapeutic management of lung cancer, while the discovery of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has revolutionized the treatment of non-small cell lung cancer (NSCLC). However, the clinical benefit of targeted therapies is limited by the eventual emergence of resistance. Identifying and monitoring the underlying mechanism of EGFR-TKI resistance could lead to more precise therapy and advances in treatment. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188363DOI Listing

Targeting tumor microenvironment in ovarian cancer: Premise and promise.

Biochim Biophys Acta Rev Cancer 2020 04 29;1873(2):188361. Epub 2020 Mar 29.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, PR China. Electronic address:

Ovarian cancer is the leading cause of gynecological cancer-related mortality globally. The majority of ovarian cancer patients suffer from relapse after standard of care therapies and the clinical benefits from cancer therapies are not satisfactory owing to drug resistance. Certain novel drugs targeting the components of tumor microenvironment (TME) have been approved by US Food and Drug Administration in solid cancers. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188361DOI Listing

RON receptor tyrosine kinase in pancreatic ductal adenocarcinoma: Pathogenic mechanism in malignancy and pharmaceutical target for therapy.

Biochim Biophys Acta Rev Cancer 2020 04 29;1873(2):188360. Epub 2020 Mar 29.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA; Zhejiang Provincial Key Laboratory of Tumor Molecular Diagnosis & Individualized Medicine, Zhejiang Provincial People's Hospital and People's Hospital of Hangzhou Medical College, Hangzhou, China. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with poor prognosis and high mortality. Molecular aberrations associated with PDAC pathogenesis and progression have been extensively investigated. Nevertheless, these findings have not been translated into clinical practice. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188360DOI Listing

Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions.

Biochim Biophys Acta Rev Cancer 2020 04 25;1873(2):188359. Epub 2020 Mar 25.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

Advanced cancer patients exhibit cachexia, a condition characterized by a significant reduction in the body weight predominantly from loss of skeletal muscle and adipose tissue. Cachexia is one of the major causes of morbidity and mortality in cancer patients. Decreased food intake and multi-organ energy imbalance in cancer patients worsen the cachexia syndrome. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188359DOI Listing
April 2020
7.845 Impact Factor

HOX genes function in Breast Cancer development.

Biochim Biophys Acta Rev Cancer 2020 04 5;1873(2):188358. Epub 2020 Mar 5.

IBMC- Institute for Molecular and Cell Biology, I3S- Institute for Innovation and Health Research, Universidade do Porto, Portugal.; ICBAS- Institute of Biomedical Sciences Abel Salazar, Universidade do Porto, Portugal.. Electronic address:

Breast cancer develops in the mammary glands during mammalian adulthood and is considered the second most common type of human carcinoma and the most incident and mortal in the female population. In contrast to other human structures, the female mammary glands continue to develop after birth, undergoing various modifications during pregnancy, lactation and involution under the regulation of hormones and transcription factors, including those encoded by the HOX clusters (A, B, C, and D). Interestingly, HOX gene deregulation is often associated to breast cancer development. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188358DOI Listing

Caspase-8: The double-edged sword.

Biochim Biophys Acta Rev Cancer 2020 04 5;1873(2):188357. Epub 2020 Mar 5.

Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R. Besides it's roles in triggering death receptor-mediated apoptosis, Caspase-8 has also been implicated in the onsets of anoikis, autophagy and pyroptosis. Furthermore, Caspase-8 also plays a crucial pro-survival function by inhibiting an alternative form of programmed cell death called necroptosis. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188357DOI Listing

Fibrosis and cancer: A strained relationship.

Biochim Biophys Acta Rev Cancer 2020 04 5;1873(2):188356. Epub 2020 Mar 5.

Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco (UCSF), USA; Departments of Radiation Oncology, Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, UCSF Helen Diller Comprehensive Cancer Center, 513 Parnassus Avenue, HSE565, San Francisco, CA 94143-0456, USA. Electronic address:

Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma enhances tumor cell growth, survival and migration and drives a mesenchymal transition. A stiff ECM also induces angiogenesis, hypoxia and compromises anti-tumor immunity. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188356DOI Listing

HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential.

Biochim Biophys Acta Rev Cancer 2020 04 2;1873(2):188355. Epub 2020 Mar 2.

Department of Surgery, Neuroscience Research Group, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada. Electronic address:

The human ether-à-go-go related gene (HERG) encodes the alpha subunit of Kv11.1, which is a voltage-gated K channel protein mainly expressed in heart and brain tissue. HERG plays critical role in cardiac repolarization, and mutations in HERG can cause long QT syndrome. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188355DOI Listing

Role of fibrillin-2 in the control of TGF-β activation in tumor angiogenesis and connective tissue disorders.

Biochim Biophys Acta Rev Cancer 2020 04 28;1873(2):188354. Epub 2020 Feb 28.

Angiogenesis Laboratory, Cancer Center Amsterdam, Department of Medical Oncology, VU University Medical Center, Amsterdam UMC, Amsterdam, the Netherlands.

Fibrillins constitute a family of large extracellular glycoproteins which multimerize to form microfibrils, an important structure in the extracellular matrix. It has long been assumed that fibrillin-2 was barely present during postnatal life, but it is now clear that fibrillin-2 molecules form the structural core of microfibrils, and are masked by an outer layer of fibrillin-1. Mutations in fibrillins give rise to heritable connective tissue disorders, including Marfan syndrome and congenital contractural arachnodactyly. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188354DOI Listing

Super-enhancers: A new frontier for glioma treatment.

Biochim Biophys Acta Rev Cancer 2020 04 26;1873(2):188353. Epub 2020 Feb 26.

Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei 230601, China. Electronic address:

Glioma is the most common primary malignant tumor in the human brain. Although there are a variety of treatments, such as surgery, radiation and chemotherapy, glioma is still an incurable disease. Super-enhancers (SEs) are implicated in the control of tumor cell identity, and they promote oncogenic transcription, which supports tumor cells. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188353DOI Listing

Control of tumor angiogenesis and metastasis through modulation of cell redox state.

Biochim Biophys Acta Rev Cancer 2020 04 5;1873(2):188352. Epub 2020 Feb 5.

Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga, Spain; CIBER de Enfermedades Raras (CIBERER), E-29071 Málaga, Spain. Electronic address:

Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the connections between redox and cancer. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188352DOI Listing

Application of organoids in translational research of human diseases with a particular focus on gastrointestinal cancers.

Biochim Biophys Acta Rev Cancer 2020 04 30;1873(2):188350. Epub 2020 Jan 30.

Storr Liver Centre, Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia. Electronic address:

Gastrointestinal (GI) cancers constitute the largest portion of all human cancers and represent a significant health burden on modern society. Conventional therapeutic approaches such as chemotherapy and surgical resections often fail due to poor treatment response or tumour relapse. Unfortunately, drug discovery for GI cancers has stalled as current cancer models fail to recapitulate critical features of the parent tumour, leading to poor translation from bench to bedside. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188350DOI Listing

Cholesterol and beyond - The role of the mevalonate pathway in cancer biology.

Biochim Biophys Acta Rev Cancer 2020 04 30;1873(2):188351. Epub 2020 Jan 30.

Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technische Universität Dresden, Germany; German Cancer Consortium (DKTK), partner site Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany; Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany.

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming and loss of cell growth control. Recently, the mevalonate pathway has emerged as a crucial regulator of tumor biology and a potential therapeutic target. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188351DOI Listing

Epigenetic memory in development and disease: Unraveling the mechanism.

Authors:
Sam Thiagalingam

Biochim Biophys Acta Rev Cancer 2020 04 23;1873(2):188349. Epub 2020 Jan 23.

Department of Medicine (Biomedical Genetics Section and Cancer Center), Department of Pathology & Laboratory Medicine, Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, United States of America. Electronic address:

Epigenetic memory is an essential process of life that governs the inheritance of predestined functional characteristics of normal cells and the newly acquired properties of cells affected by cancer and other diseases from parental to progeny cells. Unraveling the molecular basis of epigenetic memory dictated by protein and RNA factors in conjunction with epigenetic marks that are erased and re-established during embryogenesis/development during the formation of somatic, stem and disease cells will have far reaching implications to our understanding of embryogenesis/development and various diseases including cancer. While there has been enormous progress made, there are still gaps in knowledge which includes, the identity of unique epigenetic memory factors (EMFs) and epigenome coding enzymes/co-factors/scaffolding proteins involved in the assembly of defined "epigenetic memorysomes" and the epigenome marks that constitute collections of gene specific epigenetic memories corresponding to specific cell types and physiological conditions. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225062PMC

Multiple roles and context-specific mechanisms underlying YAP and TAZ-mediated resistance to anti-cancer therapy.

Biochim Biophys Acta Rev Cancer 2020 01 10;1873(1):188341. Epub 2020 Jan 10.

Laboratory of Translational Research, Azienda USL- IRCCS di Reggio Emilia, Reggio Emilia, Italy. Electronic address:

Understanding the molecular mechanisms driving resistance to anti-cancer drugs is both a crucial step to define markers of response to therapy and a clinical need in many cancer settings. YAP and TAZ transcriptional cofactors behave as oncogenes in different cancer types. Deregulation of YAP/TAZ expression or alterations in components of the multiple signaling pathways converging on these factors are important mechanisms of resistance to chemotherapy, target therapy and hormone therapy. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188341DOI Listing
January 2020

Communication in tiny packages: Exosomes as means of tumor-stroma communication.

Biochim Biophys Acta Rev Cancer 2020 04 8;1873(2):188340. Epub 2020 Jan 8.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address:

Tumor-derived exosomes are nano-sized vesicles acting as multi-signal devices influencing tumor growth at local and distant sites. Exosomes are derived from the endolysosomal compartment and can shuttle diverse biomolecules like nucleic acids (microRNAs and DNA fragments), lipids, proteins, and even pharmacological compounds from a donor cell to recipient cells. The transfer of cargo to recipient cells enables tumor-derived exosomes to influence diverse cellular functions like proliferation, cell survival, and migration in recipient cells, highlighting tumor-derived exosomes as important players in communication within the tumor microenvironment and at distant sites. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188340DOI Listing

BRCA1/P53: Two strengths in cancer chemoprevention.

Biochim Biophys Acta Rev Cancer 2020 01 7;1873(1):188339. Epub 2020 Jan 7.

LAQV/REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address:

Increasing emphasis has been given to prevention as a feasible approach to reduce the cancer burden. However, for its clinical success, further advances are required to identify effective chemopreventive agents. This review affords a critical and up-to-date discussion of issues related to cancer prevention, including an in-depth knowledge on BRCA1 and p53 tumor suppressor proteins as key molecular players. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188339DOI Listing
January 2020

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds.

Biochim Biophys Acta Rev Cancer 2020 04 3;1873(2):188338. Epub 2020 Jan 3.

Department of Pharmacological and Biomolecular Sciences, University of Milano, Milano, Italy. Electronic address:

Standard anti-cancer therapies promote tumor growth suppression mainly via induction of apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell death, thus becoming resistant to current treatments. In this setting, the interest in alternative cell death modes has recently increased. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188338DOI Listing

RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis.

Biochim Biophys Acta Rev Cancer 2020 01 2;1873(1):188337. Epub 2020 Jan 2.

Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Medical Sciences Center, Lubbock, TX 79430, USA.

RLIP (Ral-interacting protein) is a multifunctional protein that couples ATP hydrolysis with the movement of substances. Its primary function appears to be in the plasma membrane, where it catalyzes the ATP-dependent efflux of glutathione-conjugates (GS-Es), as well as un-metabolized drugs and toxins. In the plasma membrane, its interaction with the clathrin adaptor protein AP2 localizes it to endocytic vesicle, where its GS-E-stimulated ATPase and transport activity are required for clathrin-dependent endocytosis (CDE). Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188337DOI Listing
January 2020

The conflicting role of E2F1 in prostate cancer: A matter of cell context or interpretational flexibility?

Biochim Biophys Acta Rev Cancer 2020 01 21;1873(1):188336. Epub 2019 Dec 21.

Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul 03080, Republic of Korea. Electronic address:

The transcription factor E2F1 plays a crucial role in mediating multiple cancer hallmark capabilities that regulate cell cycle, survival, apoptosis, metabolism, and metastasis. Aberrant activation of E2F1 is closely associated with a poor clinical outcome in various human cancers. However, E2F1 has conflictingly been reported to exert tumor suppressive activity, raising a question as to the nature of its substantive role in the control of cell fate. Read More

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January 2020

The role of AhR in transcriptional regulation of immune cell development and function.

Biochim Biophys Acta Rev Cancer 2020 01 6;1873(1):188335. Epub 2019 Dec 6.

Cellular Therapy & Cancer Immunotherapy Program, Center for Childhood Cancer & Blood Diseases, WA-4112 Abigail Wexner Research Institute, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, United States of America.

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor (TF) that is a member of the Per-Arnt-Sim family of proteins. AhR regulates diverse processes, including malignant transformation, hematopoietic cell development, and fate determination of immune cell lineages. Moreover, AhR forms a crucial link between innate and adaptive arms of the immune system. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188335DOI Listing
January 2020

Mechanism of colorectal carcinogenesis triggered by heme iron from red meat.

Biochim Biophys Acta Rev Cancer 2020 01 26;1873(1):188334. Epub 2019 Nov 26.

Department of Toxicology, University Medical Center Mainz, 55131 Mainz, Germany; Rudolf Buchheim Institute of Pharmacology, Justus Liebig University Giessen, 35392 Giessen, Germany; Division of Food Chemistry and Toxicology, Department of Chemistry, Technical University of Kaiserslautern, 67663 Kaiserslautern, Germany. Electronic address:

Colorectal cancer (CRC) is one of the major tumor entities worldwide, with an increasing incidence in younger people. CRC formation is causally linked to various genetic, life-style and dietary risk factors. Among the ladder, the consumption of red meat has emerged as important risk factor contributing to CRC. Read More

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January 2020

Principles and methods of integrative chromatin analysis in primary tissues and tumors.

Biochim Biophys Acta Rev Cancer 2020 01 22;1873(1):188333. Epub 2019 Nov 22.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

Recent methodological advances have enabled the genome-wide interrogation of chromatin from primary tumor tissues. Integrative analysis of histone post-translational modifications, transcription factor (TF) binding and open chromatin sites in tumors across cancer stages can elucidate the aberrant epigenetic states accompanying tumor progression. Cancer-associated chromatin alterations can activate or inactivate enhancers at genes involved in cancer while still respecting cell-of-origin constrictions. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188333DOI Listing
January 2020

Targeting citrate as a novel therapeutic strategy in cancer treatment.

Biochim Biophys Acta Rev Cancer 2020 01 18;1873(1):188332. Epub 2019 Nov 18.

Division of Infectious Diseases, Allergy & Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA. Electronic address:

An important feature shared by many cancer cells is drastically altered metabolism that is critical for rapid growth and proliferation. The distinctly reprogrammed metabolism in cancer cells makes it possible to manipulate the levels of metabolites for cancer treatment. Citrate is a key metabolite that bridges many important metabolic pathways. Read More

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January 2020
7.845 Impact Factor

The intricate relationship between diabetes, obesity and pancreatic cancer.

Biochim Biophys Acta Rev Cancer 2020 01 9;1873(1):188326. Epub 2019 Nov 9.

Metabolic Signalling Group, School Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley 6102, Perth, Western Australia, Australia. Electronic address:

Pancreatic cancer is one of the leading determinants of global cancer mortality, and its incidence is predicted to increase, to become in 2030 the second most common cause of cancer-related death. Obesity and diabetes are recognized risk factors for the development of pancreatic cancer. In the last few decades an epidemic of diabetes and obesity has been spreading worldwide, forewarning an increase in incidence of pancreatic cancer. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188326DOI Listing
January 2020

Venous thromboembolism GWAS reported genetic makeup and the hallmarks of cancer: Linkage to ovarian tumour behaviour.

Biochim Biophys Acta Rev Cancer 2020 01 2;1873(1):188331. Epub 2019 Nov 2.

Molecular Oncology and Viral Pathology Group-Research Center, Portuguese Institute of Oncology, Edificio Laboratórios, 1° piso, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal; ICBAS, Abel Salazar Institute for the Biomedical Sciences, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; FMUP, Faculty of Medicine, Porto University, Porto, Portugal; CEBIMED, Faculty of Health Sciences, Fernando Pessoa University, 4200-150 Porto, Portugal. Electronic address:

Venous thromboembolism (VTE) is a common cardiovascular disease thought to be the outcome of an intricate interplay between acquired and inherited factors that act together to modify disease risk. Over the years, several single-nucleotide polymorphisms (SNPs) in candidate genes have been associated with disease risk, including F5 rs6025, F2 rs1799963, FGG rs2066865, ABO genetic variants, among others less common. More recently, genome-wide association studies (GWAS) have contributed to the identification of novel VTE-associated SNPs, some of them located in novel genes with no clear role in the haemostatic system, such as SLC44A2 rs2288904 and TSPAN15 rs78707713. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188331DOI Listing
January 2020
7.845 Impact Factor

Challenges in liver cancer and possible treatment approaches.

Biochim Biophys Acta Rev Cancer 2020 01 1;1873(1):188314. Epub 2019 Nov 1.

Department of Microbiology, Biochemistry and Immunology, Cancer Health Equity Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA. Electronic address:

Globally, liver cancer is the most frequent fatal malignancy; in the United States, it ranks fifth. Patients are often diagnosed with liver cancer in advanced stages, contributing to its poor prognosis. Of all liver cancer cases, >90% are hepatocellular carcinomas (HCCs) for which chemotherapy and immunotherapy are the best options for therapy. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981221PMC
January 2020
7.845 Impact Factor

Harnessing the therapeutic potential of anticancer drugs through amorphous solid dispersions.

Biochim Biophys Acta Rev Cancer 2020 01 31;1873(1):188319. Epub 2019 Oct 31.

Molecular Pharmaceutics and Drug Delivery Division, College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, Austin, TX 78712, USA. Electronic address:

The treatment of cancer is still a major challenge. But tremendous progress in anticancer drug discovery and development has occurred in the last few decades. However, this progress has resulted in few effective oncology products due to challenges associated with anticancer drug delivery. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188319DOI Listing
January 2020
7.845 Impact Factor

Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s).

Biochim Biophys Acta Rev Cancer 2020 01 30;1873(1):188318. Epub 2019 Oct 30.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is an incredibly deadly disease with a 5-year survival rate of 9%. The presence of pancreatic cystic lesions (PCLs) confers an increased likelihood of future pancreatic cancer in patients placing them in a high-risk category. Discerning concurrent malignancy and risk of future PCL progression to cancer must be carefully and accurately determined to improve survival outcomes and avoid unnecessary morbidity of pancreatic resection. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980327PMC
January 2020
7.845 Impact Factor

Lipoic acid a multi-level molecular inhibitor of tumorigenesis.

Authors:
D Farhat H Lincet

Biochim Biophys Acta Rev Cancer 2020 01 1;1873(1):188317. Epub 2019 Nov 1.

Université Lyon 1, Lyon, France; Inserm U1052, Centre de Recherche en Cancérologie de Lyon (CRCL), Lyon, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon (CRCL), Lyon, France; ISPB, Faculté de Pharmacie, Lyon, France. Electronic address:

We discuss how lipoic acid (LA), a natural antioxidant, induces apoptosis and inhibits proliferation, EMT, metastasis and stemness of cancer cells. Furthermore, owing to its ability to reduce chemotherapy-induced side effects and chemoresistance, LA appears to be a promising compound for cancer treatment. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188317DOI Listing
January 2020

Nervous system and gastric cancer.

Biochim Biophys Acta Rev Cancer 2020 01 21;1873(1):188313. Epub 2019 Oct 21.

State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an, China; Department of Experimental Surgery, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, China. Electronic address:

The nervous system has been recently shown to exert impact on gastric cancer directly and indirectly. Gastric cancer cells invade nerve fibers to induce outgrowth and branching of neural cells, and nerve fibers in turn infiltrate into tumor microenvironment to promote progression of gastric cancer. Additionally, the neuro-immune interaction also plays an important role in gastric cancer development. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188313DOI Listing
January 2020
7.845 Impact Factor

The association between type of endocrine therapy and development of estrogen receptor-1 mutation(s) in patients with hormone-sensitive advanced breast cancer: A systematic review and meta-analysis of randomized and non-randomized trials.

Biochim Biophys Acta Rev Cancer 2019 12 21;1872(2):188315. Epub 2019 Oct 21.

Multidisciplinary Breast Clinic Antwerp University Hospital, University of Antwerp, Antwerp, Belgium; Faculty of Medicine, University of Antwerp, Belgium.

Background: Breast cancer has, due to its high incidence, the highest mortality of cancer in women. The most common molecular type of breast cancer is the luminal subtype, which expresses estrogen and progesterone receptors and is typically treated with surgery and adjuvant endocrine therapy (ET). Estrogen receptor alpha (ERα), encoded by the estrogen receptor-1 (ESR1) gene, is expressed in approximately 70% of all breast cancers, and ET represents a major treatment modality in ERα-positive cancers. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.188315DOI Listing
December 2019