525 results match your criteria Biochimica et biophysica acta. Molecular cell research[Journal]


Ca signals triggered by bacterial pathogens and microdomains.

Biochim Biophys Acta Mol Cell Res 2018 Nov 18;1865(11 Pt B):1838-1845. Epub 2018 Aug 18.

Université Paris Sud, UMRS1174, Orsay F-91405, France; Institut National de la Santé et de la Recherche Médicale (Inserm), UMRS1174, Orsay F-91405, France. Electronic address:

Recent reports have highlighted the pivotal role of Ca during host cell infection by bacterial pathogens. Here, we review how bacterial pore-forming toxins (PFTs) trigger global Ca signals to regulate cell adhesion-, inflammatory- or death processes. We comment recent reports describing the role of bacterial effectors injected by a type III secretion system (T3SS) as well as host cell players in the formation of Ca microdomains during Shigella invasion and Chlamydia extrusion of host cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183026
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http://dx.doi.org/10.1016/j.bbamcr.2018.08.007DOI Listing
November 2018
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Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways.

Biochim Biophys Acta Mol Cell Res 2018 Nov 9;1865(11 Pt B):1718-1732. Epub 2018 Aug 9.

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA; UCI Center for Autism Research and Translation, School of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Pediatrics, Section of Human Genetics and Genomics, University of California, Irvine, Irvine, CA, USA. Electronic address:

Autism spectrum disorder (ASD) is a group of complex, neurological disorders that affect early cognitive, social, and verbal development. Our understanding of ASD has vastly improved with advances in genomic sequencing technology and genetic models that have identified >800 loci with variants that increase susceptibility to ASD. Although these findings have confirmed its high heritability, the underlying mechanisms by which these genes produce the ASD phenotypes have not been defined. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2018.08.003DOI Listing
November 2018

Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma gondii.

Biochim Biophys Acta Mol Cell Res 2018 Nov 10;1865(11 Pt B):1846-1856. Epub 2018 Aug 10.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA; Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. Electronic address:

Toxoplasma gondii has a complex life cycle involving different hosts and is dependent on fast responses, as the parasite reacts to changing environmental conditions. T. gondii causes disease by lysing the host cells that it infects and it does this by reiterating its lytic cycle, which consists of host cell invasion, replication inside the host cell, and egress causing host cell lysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183025
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http://dx.doi.org/10.1016/j.bbamcr.2018.08.004DOI Listing
November 2018
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Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics.

Biochim Biophys Acta Mol Cell Res 2019 Jul 26;1866(7):1068-1078. Epub 2018 Oct 26.

Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, 35131 Padova, Italy.

The versatility of mitochondrial metabolism and its fine adjustments to specific physiological or pathological conditions regulate fundamental cell pathways, ranging from proliferation to apoptosis. In particular, Ca signalling has emerged as a key player exploited by mitochondria to tune their activity according with cell demand. The functional interaction between mitochondria and endoplasmic reticulum (ER) deeply impacts on the correct mitochondrial Ca signal, thus modulating cell bioenergetics and functionality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183047
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http://dx.doi.org/10.1016/j.bbamcr.2018.10.016DOI Listing
July 2019
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Tumor protein D52 (isoform 3) interacts with and promotes peroxidase activity of Peroxiredoxin 1 in prostate cancer cells implicated in cell growth and migration.

Biochim Biophys Acta Mol Cell Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Applied Biology, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India. Electronic address:

Tumor protein D52 (TPD52) is overexpressed in multiple cancers including prostate cancer due to gene amplification and investigations to understand its role in the pathophysiology of different cancers are continuing. GST pull-down assays and Tandem affinity purification of TPD52 as bait identified novel prey Peroxiredoxin 1 (PRDX1) in prostate cancer (PCa) cells. PRDX1 interaction with TPD52 was confirmed in immunoprecipitation and affinity interaction assays. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.04.007DOI Listing

P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy.

Biochim Biophys Acta Mol Cell Res 2019 Apr 6;1866(8):1272-1281. Epub 2019 Apr 6.

Department of Toxicology and Nutrition, School of Public Health, Shandong University, 44 Wenhua Xi Rd., Jinan, Shandong 250012, China. Electronic address:

Diabetic nephropathy (DN) is the leading cause of end stage renal disease, posing a severe threat to public health. Previous studies reported the protective role of sirtuin 1 (SIRT1) in DN, encouraging the investigation of more potent and specific SIRT1 activators. SRT2104 is a novel, first-in-class, highly selective small-molecule activator of SIRT1, with its effect and mechanism unknown on DN. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.04.006DOI Listing
April 2019
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A new human calpastatin skipped of the inhibitory region protects calpain-1 from inactivation and degradation.

Biochim Biophys Acta Mol Cell Res 2019 Apr 5;1866(8):1260-1271. Epub 2019 Apr 5.

Department of Experimental Medicine (DIMES), Biochemistry Section, University of Genova, Viale Benedetto XV, 1-16132 Genova, Italy; Centre of Excellence for Biomedical Research (CEBR), University of Genova, Viale Benedetto XV, 7-16132 Genova, Italy. Electronic address:

Several human acute and chronic diseases involve calpain over-activation. However, the mechanistic linkages between the etiology and the progression of cell damages are not yet completely understood. Here we show that different human cells and tissues, including brain tumor specimens, cell lines of nerve origin, breast tumor samples and peripheral blood mononuclear cells from healthy donors, express a calpastatin form that lacks all the exons coding for the domains responsible of calpain inhibition. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.04.005DOI Listing

DDR1 role in fibrosis and its pharmacological targeting.

Biochim Biophys Acta Mol Cell Res 2019 Apr 5. Epub 2019 Apr 5.

Roche Pharma Research and Early Development, Roche Innovation Center Basel, Switzerland; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland. Electronic address:

Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways; however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.04.004DOI Listing

Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism.

Biochim Biophys Acta Mol Cell Res 2019 Apr 4. Epub 2019 Apr 4.

University Medical Center Hamburg-Eppendorf, Institute of Experimental Pharmacology and Toxicology, 20246 Hamburg, Germany; German Centre for Heart Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany. Electronic address:

Cardiomyocyte energy metabolism is altered in heart failure, and primary defects of metabolic pathways can cause heart failure. Studying cardiac energetics in rodent models has principal shortcomings, raising the question to which extent human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) can provide an alternative. As metabolic maturation of CM occurs mostly after birth during developmental hypertrophy, the immaturity of hiPSC-CM is an important limitation. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.04.001DOI Listing

Getting a grip on adhesion: Cadherin switching and collagen signaling.

Biochim Biophys Acta Mol Cell Res 2019 Apr 4. Epub 2019 Apr 4.

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Epithelial-mesenchymal transition (EMT) is a developmental biological process that is hijacked during tumor progression. Cadherin switching, which disrupts adherens junctions and alters cadherin-associated signaling pathways, is common during EMT. In many tumors, substantial extracellular matrix (ECM) is deposited. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.04.002DOI Listing

Dichotomy of the function of DDR1 in cells and disease progression.

Biochim Biophys Acta Mol Cell Res 2019 Apr 4. Epub 2019 Apr 4.

International Research Center for Wound Repair and Regeneration, Tainan, Taiwan; Department of Physiology, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Discoidin domain receptors DDR1 and DDR2 are collagen receptor tyrosine kinases that have many roles in tissue development and disease progression. Under physiological conditions, DDR1 is predominantly expressed in epithelial cells and functions to maintain cell differentiation and tissue homeostasis. A switch in expression from DDR1 to DDR2 occurs during epithelial-to-mesenchymal transition. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.04.003DOI Listing

Corrigendum to "HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway" [BBA - Mol. Cell Res. 1866 (2019) 750-760].

Biochim Biophys Acta Mol Cell Res 2019 Apr 3. Epub 2019 Apr 3.

College of Laboratory Medicine, Dalian Medical University, Dalian 116044, Liaoning Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.015DOI Listing
April 2019
5.019 Impact Factor

MURC/CAVIN-4 facilitates store-operated calcium entry in neonatal cardiomyocytes.

Biochim Biophys Acta Mol Cell Res 2019 Apr 2;1866(8):1249-1259. Epub 2019 Apr 2.

Département de Pharmacologie et Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, QC J1H 5N4, Canada; Institut de Pharmacologie de Sherbrooke, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada. Electronic address:

Intact store-operated calcium entry (SOCE) mechanisms ensure the maintenance of Ca homeostasis in cardiomyocytes while their dysregulation promotes the development of cardiomyopathies. To better understand this calcium handling process in cardiomyocytes, we sought to identify unknown protein partners of stromal interaction molecule 1 (STIM1), a main regulatory protein of SOCE. We identified the muscle-related coiled-coil protein (MURC), also known as Cavin-4, as a candidate and showed that MURC interacts with STIM1 in cardiomyocytes. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.017DOI Listing
April 2019
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5.019 Impact Factor

tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function.

Biochim Biophys Acta Mol Cell Res 2019 Mar 31. Epub 2019 Mar 31.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands. Electronic address:

Transfer RNAs (tRNAs) and their processing enzymes have long-recognized roles in cardiac and skeletal muscle pathophysiology. Recently, tRNA fragments have emerged as a new class of non-coding RNAs involved in the regulation of cell function. In this review, we provide a synopsis of the molecular processes that regulate the biogenesis, post-transcriptional regulation and functional roles of tRNAs in cardiac and skeletal muscle. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.012DOI Listing

The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10.

Biochim Biophys Acta Mol Cell Res 2019 Mar 31. Epub 2019 Mar 31.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China; Research Center on Aging and Medicine, Fudan University, Shanghai, China; Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China. Electronic address:

Physiological function and metabolic regulation are the most important outputs of circadian clock controls in mammals. Mitochondrial respiration and ROS production show rhythmic activity. Mitochondrial carriers, which are responsible for mitochondrial substance transfer, are vital for mitochondrial metabolism. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.016DOI Listing
March 2019
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Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation.

Biochim Biophys Acta Mol Cell Res 2019 Mar 29;1866(8):1282-1297. Epub 2019 Mar 29.

Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan, ROC; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, ROC; Graduate Institute for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan, ROC. Electronic address:

Fas-associated factor 1 (FAF1) was originally isolated as a Fas-associated factor and was subsequently found to interact with numerous other proteins that are involved in various cellular events including Fas-mediated apoptosis, nuclear factor (NF)-κB, Wnt/β-catenin, and transforming growth factor (TGF)-β signaling pathways, mineralocorticoid receptor (MR)-mediated transactivation, and ubiquitin-dependent processes. Herein, we defined two small ubiquitin-like modifier (SUMO)-interacting motifs (SIMs) within FAF1 and demonstrated to be crucial for transcriptional modulation of the MR. Our study demonstrated that the SIMs of FAF1 do not play a significant role in regulating its subcellular localization, Fas-mediated apoptosis, or NF-κB or Wnt/β-catenin pathways. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.014DOI Listing
March 2019
4 Reads

Cardiomyocyte proliferation, a target for cardiac regeneration.

Biochim Biophys Acta Mol Cell Res 2019 Mar 28. Epub 2019 Mar 28.

Aix-Marseille Univ, INSERM, MMG, U 1251, Marseille, France. Electronic address:

Cardiac diseases, characterized by cardiomyocyte loss, lead to dramatic impairment of cardiac function and ultimately to congestive heart failure. Despite significant advances, conventional treatments do not correct the defects in cardiac muscle cell numbers and the prognosis of congestive heart failure remains poor. The existence, in adult mammalian heart, of low but detectable cardiomyocyte proliferative capacities has shifted the target of regenerative therapy toward new therapeutical strategy. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.008DOI Listing

Advances in understanding the mechanisms of evasive and innate resistance to mTOR inhibition in cancer cells.

Biochim Biophys Acta Mol Cell Res 2019 Mar 27. Epub 2019 Mar 27.

Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, BO, Italy. Electronic address:

The development of drug-resistance by neoplastic cells is recognized as a major cause of targeted therapy failure and disease progression. The mechanistic (previously mammalian) target of rapamycin (mTOR) is a highly conserved Ser/Thr kinase that acts as the catalytic subunit of two structurally and functionally distinct large multiprotein complexes, referred to as mTOR complex 1 (mTORC1) and mTORC2. Both mTORC1 and mTORC2 play key roles in a variety of healthy cell types/tissues by regulating physiological anabolic and catabolic processes in response to external cues. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.013DOI Listing

What's in a cardiomyocyte - And how do we make one through reprogramming?

Biochim Biophys Acta Mol Cell Res 2019 Mar 25. Epub 2019 Mar 25.

McAllister Heart Institute, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

Substantial progress is being made in the field cardiac reprogramming, and those in the field are hopeful that the technology will be formulated for therapeutic use. Beyond the excitement around generating a revolutionary new approach for treating ischemic heart diseases, cardiac reprogramming has delivered provocative findings that challenge common notions of cell fate and cell identity. Have we really made de novo cardiomyocytes? To answer this question, the essential characteristics of this unique and important cell type must first be defined. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.011DOI Listing
March 2019
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5.019 Impact Factor

Dual knockdown of Galectin-8 and its glycosylated ligand, the activated leukocyte cell adhesion molecule (ALCAM/CD166), synergistically delays in vivo breast cancer growth.

Biochim Biophys Acta Mol Cell Res 2019 Mar 21. Epub 2019 Mar 21.

Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro Paladini (CONICET-UBA), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. Electronic address:

Galectin-8 (Gal-8), a 'tandem-repeat'-type galectin, has been described as a modulator of cellular functions including adhesion, spreading, growth arrest, apoptosis, pathogen recognition, autophagy, and immunomodulation. We have previously shown that activated leukocyte cell adhesion molecule (ALCAM), also known as CD166, serves as a receptor for endogenous Gal-8. ALCAM is a member of the immunoglobulin superfamily involved in cell-cell adhesion through homophilic (ALCAM-ALCAM) and heterophilic (i. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.010DOI Listing

Cannabinoid-sensitive receptors in cardiac physiology and ischaemia.

Authors:
Sarah-Lena Puhl

Biochim Biophys Acta Mol Cell Res 2019 Mar 16. Epub 2019 Mar 16.

Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Pettenkoferstrasse 9, 80336 Munich, Germany. Electronic address:

The classical cannabinoid receptors CB1 and CB2 as well as the cannabinoid-sensitive receptor GPR55 are widely distributed throughout the mammalian body. In the cardiovascular field, CB1 and CB2 crucially impact on diseases characterized by inflammatory processes, such as atherosclerosis and acute myocardial infarction. Both receptors and their endogenous ligands anandamide and 2-arachidonoylglycerol are up-regulated in the ischaemic heart in humans and animal models. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.009DOI Listing
March 2019
7 Reads

Oxygen as a key regulator of cardiomyocyte proliferation: New results about cell culture conditions!

Biochim Biophys Acta Mol Cell Res 2019 Mar 15. Epub 2019 Mar 15.

Division of Angiology, Heart and Vessel department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland. Electronic address:

The goal of the new therapeutically strategies aimed to treat cardiovascular diseases (CVDs) is to enhance the natural ability of the heart to regenerate. This represents a great challenge for the coming years as all the mechanisms underlying the replacement of dying cells by functional cells of the same type are not completely elucidated. Among these, stimulating cardiomyocyte proliferation seems to be crucial for the restoration of normal cardiac function after CVDs. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.007DOI Listing

Using synthetic peptides and recombinant collagen to understand DDR-collagen interactions.

Biochim Biophys Acta Mol Cell Res 2019 Mar 15. Epub 2019 Mar 15.

Department of Chemistry, Tufts University, Medford, MA 02155, USA. Electronic address:

The discoidin domain receptors, DDR1 and DDR2, are a subfamily of receptor tyrosine kinases that are activated upon binding to collagen. DDR-collagen interactions play an important role in cell proliferation and migration. Over the past few decades, synthetic peptides and recombinant collagen have been developed as tools to study the biophysical characteristics of collagen and various protein-collagen interactions. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.005DOI Listing

Role of HDACs in cardiac electropathology: Therapeutic implications for atrial fibrillation.

Biochim Biophys Acta Mol Cell Res 2019 Mar 14. Epub 2019 Mar 14.

Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, the Netherlands.. Electronic address:

Perpetuation of atrial fibrillation (AF) is caused by electropathology, which is defined as impairment of electrical activation caused by structural and metabolic remodeling of cardiomyocytes. We previously dissected the molecular mechanisms underlying electropathology and identified an important role for histone deacetylases (HDACs). HDACs catalyze the removal of acetyl-groups from lysine residues within nucleosomal histone tails and many non-histone proteins. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.006DOI Listing

Lactate dehydrogenase A regulates autophagy and tamoxifen resistance in breast cancer.

Biochim Biophys Acta Mol Cell Res 2019 Jun 13;1866(6):1004-1018. Epub 2019 Mar 13.

School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India. Electronic address:

Estrogen receptor (ER) antagonist, tamoxifen has been universally used for the treatment of the ER-positive breast cancer; however, the inevitable emergence of resistance to tamoxifen obstructs the successful treatment of this cancer. So, there is an immediate requirement for the search of a novel therapeutic target for treatment of this cancer. Acquired tamoxifen-resistant breast cancer cell lines MCF-7 (MCF-7/TAM-R) and T47D (T47D/TAM-R) showed higher apoptotic resistance accompanied by induction of pro-survival autophagy compared to their parental cells. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.004DOI Listing
June 2019
5.019 Impact Factor

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo.

Biochim Biophys Acta Mol Cell Res 2019 Jun 10;1866(6):992-1003. Epub 2019 Mar 10.

School of Pharmacy, College of Medicine, National Taiwan University, No. 33, Linsen S. Road, Taipei 10050, Taiwan. Electronic address:

Triple-negative breast cancer (TNBC) is associated with an increased risk of metastasis and a poor prognosis. The invasive ability of TNBC relies on actin reorganization and is regulated by histone deacetylase 6 (HDAC6). The present study aimed to examine the effect of MPT0G211, a novel HDAC6 inhibitor, on cell migration and microtubule association in both in vitro and in vivo models of TNBC. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.003DOI Listing

Long-term self-renewal of naïve neural stem cells in a defined condition.

Biochim Biophys Acta Mol Cell Res 2019 Jun 9;1866(6):971-977. Epub 2019 Mar 9.

Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology & Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America. Electronic address:

During embryonic development, neural stem cells (NSCs) emerge as early as the neural plate stage and give rise to the nervous system. Early-stage NSCs express Sry-related-HMG box-1 (Sox1) and are biased towards neuronal differentiation. However, long-term maintenance of early-stage NSCs in vitro remains a challenge. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.001DOI Listing

CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation.

Biochim Biophys Acta Mol Cell Res 2019 Jun 8;1866(6):978-991. Epub 2019 Mar 8.

Division of Cell Signalling and Immunology, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Electronic address:

Extracellular amino acid (AA) withdrawal/restriction invokes an integrated stress response (ISR) that induces global suppression of protein synthesis whilst allowing transcription and translation of a select group of genes, whose protein products facilitate cellular adaptation to AA insufficiency. Transcriptional induction of the System A/SNAT2 AA transporter represents a classic adaptation response and crucially depends upon activation of the General Control Nonderepressible-2 kinase/Activating transcription factor 4 (GCN2/ATF4) pathway. However, the ISR may also include additional signalling inputs operating in conjunction or independently of GCN2/ATF4 to upregulate SNAT2. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456927PMC

Autophagy in cardiomyopathies.

Biochim Biophys Acta Mol Cell Res 2019 Feb 6. Epub 2019 Feb 6.

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg, Hamburg, Germany; German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany. Electronic address:

Autophagy (greek auto: self; phagein: eating) is a highly conserved process within eukaryotes that degrades long-lived proteins and organelles within lysosomes. Its accurate and constant operation in basal conditions ensures cellular homeostasis by degrading damaged cellular components and thereby acting not only as a quality control but as well as an energy supplier. An increasing body of evidence indicates a major role of autophagy in the regulation of cardiac homeostasis and function. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.01.013DOI Listing
February 2019
2 Reads

An element for development: Calcium signaling in mammalian reproduction and development.

Biochim Biophys Acta Mol Cell Res 2019 Jul 28;1866(7):1230-1238. Epub 2019 Feb 28.

Mater Research Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, QLD, Australia; Translational Research Institute, Woolloongabba, QLD, Australia. Electronic address:

Life begins with calcium. It is the language that a sperm cell uses to respond to instructions from the female reproductive tract to alter its swimming pattern and gain the force required to penetrate the outer layers of the oocyte. The first heartbeat transpires from spontaneous calcium oscillations in embryonic cardiomyocytes. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.016DOI Listing

Nuclear proteasomal degradation of Saccharomyces cerevisiae inorganic pyrophosphatase Ipp1p, a nucleocytoplasmic protein whose stability depends on its subcellular localization.

Biochim Biophys Acta Mol Cell Res 2019 Jun 28;1866(6):1019-1033. Epub 2019 Feb 28.

Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla-CSIC, Av. Américo Vespucio 49, 41092 Sevilla, Spain. Electronic address:

Inorganic pyrophosphate (PPi) is an abundant by-product of cellular metabolism. PPi-producing reactions take place in the nucleus concurrently with reactions that use PPi as a substrate. Saccharomyces cerevisiae possesses two soluble pyrophosphatases (sPPases): Ipp1p, an essential and allegedly cytosolic protein, and Ipp2p, a mitochondrial isoenzyme. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.015DOI Listing
June 2019
2 Reads

Rat-derived feeder cells immortalized by expression of mutant CDK4, cyclin D, and telomerase can support stem cell growth.

Biochim Biophys Acta Mol Cell Res 2019 May 1;1866(5):945-956. Epub 2019 Mar 1.

National Institute for Environmental studies, Wildlife Genome Collaborative Research Group, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan; Iwate University, Graduate School of Science and Engineering, 4-3-5, Ueda, Morioka 020-8551, Japan; Soft-Path Engineering Research Center (SPERC), Iwate University, Morioka, Japan. Electronic address:

The maintenance of stem cells often requires the support of feeder cells. Primary mouse embryonic fibroblasts (MEFs) have traditionally been used as feeder cells, and although these MEF-derived feeder cells have exhibited a reasonable performance, they require repeated cell isolation, since MEFs cannot expand indefinitely. To overcome this limitation, immortalized cells, such as STO cells, have been used. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.013DOI Listing

Mechanistic insights into store-operated Ca entry during excitation-contraction coupling in skeletal muscle.

Biochim Biophys Acta Mol Cell Res 2019 Jul 27;1866(7):1239-1248. Epub 2019 Feb 27.

School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.

Skeletal muscle fibres support store-operated Ca-entry (SOCE) across the t-tubular membrane upon exhaustive depletion of Ca from the sarcoplasmic reticulum (SR). Recently we demonstrated the presence of a novel mode of SOCE activated under conditions of maintained [Ca]. This phasic SOCE manifested in a fast and transient manner in synchrony with excitation contraction (EC)-coupling mediated SR Ca-release (Communications Biology 1:31, doi: https://doi. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.014DOI Listing

Mitochondrial presequence import: Multiple regulatory knobs fine-tune mitochondrial biogenesis and homeostasis.

Biochim Biophys Acta Mol Cell Res 2019 May 22;1866(5):930-944. Epub 2019 Feb 22.

Laboratoire de Microbiologie et Génétique Moléculaires, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Toulouse, France. Electronic address:

Mitochondria are pivotal organelles for cellular signaling and metabolism, and their dysfunction leads to severe cellular stress. About 60-70% of the mitochondrial proteome consists of preproteins synthesized in the cytosol with an amino-terminal cleavable presequence targeting signal. The TIM23 complex transports presequence signals towards the mitochondrial matrix. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.012DOI Listing
May 2019
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Establishing life is a calcium-dependent TRiP: Transient receptor potential channels in reproduction.

Biochim Biophys Acta Mol Cell Res 2018 Nov 9;1865(11 Pt B):1815-1829. Epub 2018 Aug 9.

Laboratory of Endometrium, Endometriosis & Reproductive Medicine, Department Development & Regeneration, KU Leuven, G-PURE, Leuven, Belgium. Electronic address:

Calcium plays a key role in many different steps of the reproduction process, from germ cell maturation to placental development. However, the exact function and regulation of calcium throughout subsequent reproductive events remains rather enigmatic. Successful pregnancy requires the establishment of a complex dialogue between the implanting embryo and the endometrium. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2018.08.005DOI Listing
November 2018
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Calcium signaling in health, disease and therapy.

Biochim Biophys Acta Mol Cell Res 2018 Nov 30;1865(11 Pt B):1657-1659. Epub 2018 Aug 30.

KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2018.08.019DOI Listing
November 2018
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Pathophysiological characterization of MERRF patient-specific induced neurons generated by direct reprogramming.

Biochim Biophys Acta Mol Cell Res 2019 May 22;1866(5):861-881. Epub 2019 Feb 22.

Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain. Electronic address:

Mitochondrial diseases are a group of rare heterogeneous genetic disorders caused by total or partial mitochondrial dysfunction. They can be caused by mutations in nuclear or mitochondrial DNA (mtDNA). MERRF (Myoclonic Epilepsy with Ragged-Red Fibers) syndrome is one of the most common mitochondrial disorders caused by point mutations in mtDNA. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.010DOI Listing
May 2019
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The vacuolar shapes of ageing: From function to morphology.

Biochim Biophys Acta Mol Cell Res 2019 May 21;1866(5):957-970. Epub 2019 Feb 21.

Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, 8010 Graz, Austria; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20C, 106 91 Stockholm, Sweden. Electronic address:

Cellular ageing results in accumulating damage to various macromolecules and the progressive decline of organelle function. Yeast vacuoles as well as their counterpart in higher eukaryotes, the lysosomes, emerge as central organelles in lifespan determination. These acidic organelles integrate enzymatic breakdown and recycling of cellular waste with nutrient sensing, storage, signalling and mobilization. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.011DOI Listing
May 2019
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BAG3 deletion suppresses stem cell-like features of pancreatic ductal adenocarcinoma via translational suppression of ISG15.

Biochim Biophys Acta Mol Cell Res 2019 May 14;1866(5):819-827. Epub 2019 Feb 14.

Department of Biochemistry & Molecular Biology, China Medical University, Shenyang 110122, China; Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, China. Electronic address:

BAG3 is a member of the cochaperone BAG family and often highly expressed in various cancers. Recently, evidences show that BAG3 promotes stemness of human cancer cells. IFN-stimulated genes 15 (ISG15) is an ubiquitin-like molecule, which is covalently conjugated with substrates to form ISGylated proteins. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.008DOI Listing
May 2019
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Lysosomal regulation of extracellular vesicle excretion during d-ribose-induced NLRP3 inflammasome activation in podocytes.

Biochim Biophys Acta Mol Cell Res 2019 May 14;1866(5):849-860. Epub 2019 Feb 14.

Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, United States of America. Electronic address:

The NLRP3 inflammasome is activated in the cytoplasm of cells and its products such as IL-1β are exported through a non-classical ER-Golgi pathway. Several mechanistically distinct models including exocytosis of secretory lysosomes, microvesicles (MVs) and extracellular vehicles (EVs) have been proposed for their release. In this study, we hypothesized that the NLRP3 inflammasome product, IL-1β in response to exogenously administrated and endogenously produced d-ribose stimulation is released via extracellular vesicles including EVs via a sphingolipid-mediated molecular mechanisms controlling lysosome and multivesicular body (MVB) interaction. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.007DOI Listing
May 2019
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DENN domain-containing protein FAM45A regulates the homeostasis of late/multivesicular endosomes.

Biochim Biophys Acta Mol Cell Res 2019 May 13;1866(5):916-929. Epub 2019 Feb 13.

Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, Jiangsu 215123, China. Electronic address:

DENN (differentially expressed in normal cells and neoplasia) domain-containing proteins are a family of guanine nucleotide exchange factors (GEFs) for Rab small GTPases and coordinate a plethora of intracellular membrane trafficking events. FAM45A is a non-classical DENN domain protein, whose function was unknown. In this study, we characterized cellular roles of FAM45A. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.006DOI Listing
May 2019
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PKA negatively modulates the migration enhancing effect of Connexin 43.

Biochim Biophys Acta Mol Cell Res 2019 May 12;1866(5):828-838. Epub 2019 Feb 12.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München and Munich University Hospital, Großhaderner Str. 9, 82152 Planegg, Martinsried, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Biedersteiner Str. 29, 80802 München, Germany. Electronic address:

Connexin 43 (Cx43) expression is associated with an increased cell migration and related changes of the actin cytoskeleton (enhanced filopodia formation). These effects are mediated by the C-terminal cytoplasmic part of Cx43 in a channel-independent manner. Since this part has been shown to interact with a variety of proteins and has multiple phosphorylation sites we analyzed here a potential role of the protein kinase A (PKA) for the Cx43 mediated increase in cell migration. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.001DOI Listing
May 2019
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5' processing of Saccharomyces cerevisiae mitochondrial tRNAs requires expression of multiple genes.

Biochim Biophys Acta Mol Cell Res 2019 May 10;1866(5):806-818. Epub 2019 Feb 10.

Departamento de Microbiologia - Instituto de Ciências Biomédicas, University of São Paulo, São Paulo, Brazil. Electronic address:

Mitochondrial tRNAs are processed at their 5'ends by highly divergent but ubiquitous RNase P. In Saccharomyces cerevisiae, Rpm2p is the protein component of RNase P. Here, we identify four novel genes MTA1, MTA2, GEP5 and PET130 of the Saccharomycetaceae family that are necessary for an efficient processing of mitochondrial tRNAs. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.002DOI Listing
May 2019
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HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway.

Biochim Biophys Acta Mol Cell Res 2019 May 8;1866(5):750-760. Epub 2019 Feb 8.

College of Laboratory Medicine, Dalian Medical University, Dalian 116044, Liaoning Province, China. Electronic address:

Metastasis is the main cause of death in colorectal cancer (CRC) patients. Aberrant fucosylation, catalyzed by the specific fucosyltransferases (FUTs), is associated with malignant behaviors. Non-conding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), emerge as key molecules in cancer malignancy. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.004DOI Listing
May 2019
2 Reads
5.019 Impact Factor

Mix and (mis-)match - The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart.

Biochim Biophys Acta Mol Cell Res 2019 Feb 8. Epub 2019 Feb 8.

Division of Bioengineering, School of Engineering and Materials Science & Institute for Bioengineering, Queen Mary University of London, United Kingdom. Electronic address:

The composition and the stiffness of cardiac microenvironment change during development and/or in heart disease. Cardiomyocytes (CMs) and their progenitors sense these changes, which decides over the cell fate and can trigger CM (progenitor) proliferation, differentiation, de-differentiation or death. The field of mechanobiology has seen a constant increase in output that also includes a wealth of new studies specific to cardiac or cardiomyocyte mechanosensing. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.01.017DOI Listing
February 2019
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Phosphatidylinositol-3-phosphate-mediated actin domain formation linked to DNA synthesis upon insulin treatment in rat hepatoma-derived H4IIEC3 cells.

Biochim Biophys Acta Mol Cell Res 2019 May 8;1866(5):793-805. Epub 2019 Feb 8.

Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8503, Japan; Laboratory of Frontier Image Analysis, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. Electronic address:

Phosphatidylinositol-3-phosphate (PI3P) is a lipid that accumulates in the early endosomal membrane, and acts as a scaffold to recruit proteins that contain a PI3P-binding domain, such as the FYVE domain. In this study, we examined the effect of PI3P depletion on the insulin response in rat hepatoma-derived H4IIEC3 cells. We found that insulin treatment induced the transient formation of an actin domain structure, a mesh-like tangled network of actin filaments where phosphorylated Akt, endosomal proteins, and PI3P accumulated. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.005DOI Listing
May 2019
3 Reads

The M-band: The underestimated part of the sarcomere.

Biochim Biophys Acta Mol Cell Res 2019 Feb 7. Epub 2019 Feb 7.

Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK; School of Cardiovascular Medicine and Sciences, British Heart Foundation Research Excellence Centre, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK. Electronic address:

The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and associated proteins) and thick (myosin and associated proteins) filaments to the elastic filament system composed of titin. A plethora of proteins are known to be integral or associated proteins of the Z-disc and its structural and signalling role in muscle is better understood, while the molecular constituents of the M-band and its function are less well defined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183034
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http://dx.doi.org/10.1016/j.bbamcr.2019.02.003DOI Listing
February 2019
4 Reads

Regulation of extracellular ATP of human erythrocytes treated with α-hemolysin. Effects of cell volume, morphology, rheology and hemolysis.

Biochim Biophys Acta Mol Cell Res 2019 May 3;1866(5):896-915. Epub 2019 Feb 3.

Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química y Fisico-Química Biológicas (IQUIFIB) "Prof. Alejandro C. Paladini", Facultad de Farmacia y Bioquímica, Junín 956 Buenos Aires, Argentina.; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Cátedra de Química Biológica Superior, Junín 956 Buenos Aires, Argentina.. Electronic address:

Alpha-hemolysin (HlyA) of uropathogenic strains of Escherichia coli irreversibly binds to human erythrocytes (RBCs) and triggers activation of ATP release and metabolic changes ultimately leading to hemolysis. We studied the regulation of extracellular ATP (ATPe) of RBCs exposed to HlyA. Luminometry was used to assess ATP release and ATPe hydrolysis, whereas changes in cell volume and morphology were determined by electrical impedance, ektacytometry and aggregometry. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.01.018DOI Listing

Loss of Peter Pan protein is associated with cell cycle defects and apoptotic events.

Biochim Biophys Acta Mol Cell Res 2019 May 1;1866(5):882-895. Epub 2019 Feb 1.

Institute of Biochemistry and Molecular Biology, Ulm University, Ulm, Germany. Electronic address:

The nucleolus is a subnuclear compartment, which governs ribosome biogenesis. Moreover, it functions as hub in the stress response by orchestrating a variety of processes, such as regulation of cell cycle progression, senescence and apoptosis. Emerging evidence links the nucleolus also to the control of genomic stability and the development of human malignancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183037
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http://dx.doi.org/10.1016/j.bbamcr.2019.01.010DOI Listing
May 2019
10 Reads