626 results match your criteria Biochimica et biophysica acta. Molecular and cell biology of lipids[Journal]


Toll-like receptor signaling induces a temporal switch towards a resolving lipid profile in monocyte-derived macrophages.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 21:158740. Epub 2020 May 21.

Leiden University Medical Center, Department of Rheumatology, Leiden, the Netherlands.

Inflammation is a tightly regulated process. During the past decade it has become clear that the resolution of inflammation is an active process and its dysregulation can contribute to chronic inflammation. Several cells and soluble mediators, including lipid mediators, regulate the course of inflammation and its resolution. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158740DOI Listing

Lipidomics reveals how the endoparasitoid wasp Pteromalus puparum manipulates host energy stores for its young.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 10:158736. Epub 2020 May 10.

State Key Laboratory of Rice Biology & Agricultural and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

Endoparasitoid wasps inject venom along with their eggs to adjust the physiological and nutritional environment inside their hosts to benefit the development of their offspring. In particular, wasp venoms are known to modify host lipid metabolism, lipid storage in the fat body, and release of lipids into the hemolymph, but how venoms accomplish these functions remains unclear. Here, we use an UPLC-MS-based lipidomics approach to analyze the identities and concentrations of lipids in both fat body and hemolymph of host cabbage butterfly (Pieris rapae) infected by the pupal endoparasitoid Pteromalus puparum. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158736DOI Listing

Lipidomic analysis of epithelial corneal cells following hyperosmolarity and benzalkonium chloride exposure: New insights in dry eye disease.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 10:158728. Epub 2020 May 10.

Chimie Toxicologie Analytique et Cellulaire CNRS UMR 8038, Université Paris Descartes, Faculté de Pharmacie, Sorbonne Paris Cité, Paris, France. Electronic address:

Dry eye disease (DED) is a multifactorial chronic inflammatory disease of the ocular surface characterized by tear film instability, hyperosmolarity, cell damage and inflammation. Hyperosmolarity is strongly established as the core mechanism of the DED. Benzalkonium chloride (BAK) - a quaternary ammonium salt commonly used in eye drops for its microbicidal properties - is well known to favor the onset of DED. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158728DOI Listing

Olesoxime, a cholesterol-like neuroprotectant restrains synaptic vesicle exocytosis in the mice motor nerve terminals: Possible role of VDACs.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 16:158739. Epub 2020 May 16.

Laboratory of Biophysics of Synaptic Processes, Kazan Institute of Biochemistry and Biophysics, Federal Research Center "Kazan Scientific Center of RAS", 2/31 Lobachevsky Street, box 30, Kazan 420111, Russia; Institute of Neuroscience, Kazan State Medial University, 49 Butlerova Street, Kazan 420012, Russia. Electronic address:

Olesoxime is a cholesterol-like neuroprotective compound that targets to mitochondrial voltage dependent anion channels (VDACs). VDACs were also found in the plasma membrane and highly expressed in the presynaptic compartment. Here, we studied the effects of olesoxime and VDAC inhibitors on neurotransmission in the mouse neuromuscular junction. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158739DOI Listing

Regulation of lipid droplet homeostasis by hypoxia inducible lipid droplet associated HILPDA.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 11;1865(9):158738. Epub 2020 May 11.

Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, the Netherlands. Electronic address:

Nearly all cell types have the ability to store excess energy as triglycerides in specialized organelles called lipid droplets. The formation and degradation of lipid droplets is governed by a diverse set of enzymes and lipid droplet-associated proteins. One of the lipid droplet-associated proteins is Hypoxia Inducible Lipid Droplet Associated (HILPDA). Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158738DOI Listing

Niacin increases diet-induced hepatic steatosis in B6129 mice.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 10:158731. Epub 2020 May 10.

Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States of America. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is a very common disorder affecting between 20 and 30% of adults in the United States. However, there is no effective pharmacotherapy for treating NAFLD. Niacin, a water-soluble vitamin (B3), at pharmacological doses, decreases hepatic triglyceride (TG) content in NAFLD through inhibition of diacylglycerol acyltransferase 2, a key enzyme that catalyzes the final step in TG synthesis. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158731DOI Listing

Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 10:158737. Epub 2020 May 10.

Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria. Electronic address:

Aberrant fatty acid (FA) metabolism is a hallmark of proliferating cells, including untransformed fibroblasts or cancer cells. Lipolysis of intracellular triglyceride (TG) stores by adipose triglyceride lipase (ATGL) provides an important source of FAs serving as energy substrates, signaling molecules, and precursors for membrane lipids. To investigate if ATGL-mediated lipolysis impacts cell proliferation, we modified ATGL activity in murine embryonic fibroblasts (MEFs) and in five different cancer cell lines to determine the consequences on cell growth and metabolism. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158737DOI Listing

Roles for lysophosphatidic acid signaling in vascular development and disease.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 3;1865(8):158734. Epub 2020 May 3.

Division of Cardiovascular Medicine, The Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY 40536, United States of America; Veterans Affairs Medical Center, Lexington, KY 40511, United States of America.

The bioactive lipid lysophosphatidic acid (LPA) is emerging as an important mediator of inflammation in cardiovascular diseases. Produced in large part by the secreted lysophospholipase D autotaxin (ATX), LPA acts on a series of G protein-coupled receptors and may have action on atypical receptors such as RAGE to exert potent effects on vascular cells, including the promotion of foam cell formation and phenotypic modulation of smooth muscle cells. The signaling effects of LPA can be terminated by integral membrane lipid phosphate phosphatases (LPP) that hydrolyze the lipid to receptor inactive products. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158734DOI Listing

Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 1;1865(9):158733. Epub 2020 May 1.

Dipartimento di Scienze Biomediche e Chirurgiche, Università di Perugia, Perugia, Italy. Electronic address:

The farnesoid-X-receptor (FXR) is validated target in the cholestatic disorders treatment. Obeticholic acid (OCA), the first in class of FXR agonist approved for clinical use, causes side effects including acute liver decompensation when administered to cirrhotic patients with primary biliary cholangitis at higher than recommended doses. The V-Maf avian-musculoaponeurotic-fibrosarcoma-oncogene-homolog-G (Mafg) and nuclear factor-erythroid-2-related-factor-2 (Nrf2) mediates some of the downstream effects of FXR. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158733DOI Listing

Increased plasma levels of palmitoleic acid may contribute to beneficial effects of Krill oil on glucose homeostasis in dietary obese mice.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 1;1865(8):158732. Epub 2020 May 1.

Laboratory of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic.

Omega-3 polyunsatuarted fatty acids (PUFA) are associated with hypolipidemic and anti-inflammatory effects. However, omega-3 PUFA, usually administered as triacylglycerols or ethyl esters, could also compromise glucose metabolism, especially in obese type 2 diabetics. Phospholipids represent an alternative source of omega-3 PUFA, but their impact on glucose homeostasis is poorly explored. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158732DOI Listing

Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 1;1865(8):158730. Epub 2020 May 1.

Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstraße 31/II, A-8010 Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:

Vitamin A is stored as retinyl esters (REs) in lipid droplets of hepatic stellate cells (HSCs). To date, two different pathways are known to facilitate the breakdown of REs: (i) Hydrolysis of REs by neutral lipases, and (ii) whole lipid droplet degradation in autolysosomes by acid hydrolysis. In this study, we evaluated the contribution of neutral and acid RE hydrolases to the breakdown of REs in human HSCs. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158730DOI Listing
May 2020
5.162 Impact Factor

Knockdown of CTRP6 reduces the deposition of intramuscular and subcutaneous fat in pigs via different signaling pathways.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 28;1865(8):158729. Epub 2020 Apr 28.

College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. Electronic address:

The regulation of porcine subcutaneous (SC) and intramuscular (IM) fat deposition significantly affects pork quality and the lean meat percentage of the carcass, respectively. The adipokine C1q/tumor necrosis factor-related protein 6 (CTRP6), plays a significant role in regulating animal fat deposition. The purpose of this study was to understand the effects of CTRP6 gene knockdown in IM and SC adipocytes by RNA-seq analysis. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158729DOI Listing

Corrigendum to "Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells" [BBA-Mol. Cell Biol. Volume 1863/2, Pages 152-164].

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 27:158701. Epub 2020 Apr 27.

Institute of Biochemistry, Charite - University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2020.158701DOI Listing

Enhanced peripheral blood miR-324-5p is associated with the risk of metabolic syndrome by suppressing ROCK1.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 27;1865(8):158727. Epub 2020 Apr 27.

The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China. Electronic address:

The current study aims to evaluate whether peripheral blood miR-324-5p could be used to differentiate patients with metabolic disorders and healthy controls. Our data showed that miR-324-5p levels were elevated in the peripheral blood of patients with hyperglycemia or hyperlipidemia. In addition, the expression of miR-324-5p was enhanced in the peripheral blood and liver of db/db mice. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158727DOI Listing

Catalase is required for peroxisome maintenance during adipogenesis.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 23;1865(8):158726. Epub 2020 Apr 23.

Division of Life Science, Department of Pharmacy, Hokkaido University of Science, 7-15-4-1 Maeda, Teine, Sapporo, Hokkaido 006-8585, Japan. Electronic address:

Although obesity contributes to the onset and pathogenesis of metabolic diseases, it has been repeatedly demonstrated that being overweight or mildly obese carries a survival advantage compared with being thin or normal-weight. This relationship is called the obesity paradox. Hence, it is necessary to clarify the underlying mechanism of obesity onset for the prevention and treatment of these diseases. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158726DOI Listing

Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 21;1865(8):158715. Epub 2020 Apr 21.

Pathophysiology, Diagnosis and treatments of bone diseases, INSERM UMR1033, Lyon, France. Electronic address:

Lysphosphatidic acid (LPA) is a major natural bioactive lipid mediator whose biological functions affect multiple organs. These include bone as demonstrated by global Lpar1-knockout mice (Lpar1) which present a bone growth defect. LPA acts on all bone cells including osteoblasts, that are responsible for bone formation, and osteoclasts, which are specialized cells that resorb bone. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158715DOI Listing

VLDL and HDL attenuate endoplasmic reticulum and metabolic stress in HL-1 cardiomyocytes.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 21;1865(8):158713. Epub 2020 Apr 21.

Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address:

Lipoproteins have a vital role in the development of metabolic and cardiovascular diseases ranging from protective to deleterious effects on target tissues. VLDL has been shown to induce lipotoxic lipid accumulation and exert a variety of negative effects on cardiomyocytes. Lipotoxicity and endoplasmic reticulum (ER) stress are proposed to be the mediators of damaging effects of metabolic diseases on cardiovascular system. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158713DOI Listing

Identification and functional characterization of a lipid droplet protein CtLDP1 from an oleaginous yeast Candida tropicalis SY005.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 19;1865(8):158725. Epub 2020 Apr 19.

Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. Electronic address:

Proteins residing in lipid droplets (LDs) of organisms exhibit diverse physiological roles. Since the LD proteins of yeasts are largely unexplored, we have identified a putative LD protein gene, CtLDP1 in the oleaginous yeast Candida tropicalis SY005 and characterized its function. The increased lipid accumulation in SY005 could be correlated with enhanced (~2. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158725DOI Listing

Role of the autotaxin-lysophosphatidate axis in the development of resistance to cancer therapy.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 16;1865(8):158716. Epub 2020 Apr 16.

Department of Biochemistry, University of Alberta, Edmonton T6G 2S2, Canada; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton T6G 2S2, Canada. Electronic address:

Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to produce lysophosphatidate (LPA), which signals through six G-protein coupled receptors (GPCRs). Signaling through LPA is terminated by its degradation by a family of three lipid phosphate phosphatases (LPPs). LPP1 also attenuates signaling downstream of the activation of LPA receptors and some other GPCRs. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158716DOI Listing
April 2020
5.162 Impact Factor

Potential role of aryl hydrocarbon receptor signaling in childhood obesity.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 14;1865(8):158714. Epub 2020 Apr 14.

Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Background: There is a growing concern that junk food has contributed to the childhood obesity epidemic. Recently, experimental studies suggested that the aryl hydrocarbon receptor (AHR) gene is strongly linked to western diet-induced obesity.

Aim: This study investigated the potential role of AHR signaling in childhood obesity and the possible associations of the AHR-aryl hydrocarbon receptor repressor (AHRR)-cytochrome P450 1B1 (CYP1B1) axis with fatty acid homeostasis and the appetite-related hormones, leptin and ghrelin. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158714DOI Listing
April 2020
5.162 Impact Factor

Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 11;1865(8):158712. Epub 2020 Apr 11.

Department of Physiology & Biophysics, Boston University School of Medicine, Boston, MA 02118, USA; Amyloidosis Treatment and Research Center, Boston University School of Medicine, Boston MA, USA.

Low-density lipoprotein (LDL) binding to arterial proteoglycans initiates LDL retention and modification in the arterial wall, triggering atherosclerosis. The details of this binding, its effectors, and its ramifications are incompletely understood. We combined heparin affinity chromatography with biochemical, spectroscopic and electron microscopic techniques to show that brief binding to heparin initiates irreversible pro-atherogenic remodeling of human LDL. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158712DOI Listing

Differential postprandial incorporation of 20:5n-3 and 22:6n-3 into individual plasma triacylglycerol and phosphatidylcholine molecular species in humans.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 11;1865(8):158710. Epub 2020 Apr 11.

School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK. Electronic address:

The mechanisms by which digested fat is absorbed and transported in the circulation are well documented. However, it is uncertain whether the molecular species composition of dietary fats influences the molecular species composition of meal-derived lipids in blood. This may be important because enzymes that remove meal-derived fatty acids from the circulation exhibit differential activities towards individual lipid molecular species. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158710DOI Listing

Regulation of adiponectin on lipid metabolism in large yellow croaker (Larimichthys crocea).

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 11;1865(8):158711. Epub 2020 Apr 11.

Key Laboratory of Aquaculture Nutrition and Feed (Ministry of Agriculture and Rural Affairs), Key Laboratory of Mariculture (Ministry of Education), Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, PR China; Laboratory for Marine Fisheries and Aquaculture, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong 266003, PR China. Electronic address:

Adiponectin (APN), an adipose tissue-derived hormone, plays a key role in regulating energy metabolism in mammals. However, its physiological roles in teleosts remain poorly understood. In the present study, the apn gene was cloned from large yellow croaker, which was mainly expressed in the adipose, muscle and liver. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158711DOI Listing

S1P-lyase deficiency uncouples ganglioside formation - Potential contribution to tumorigenic capacity.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 10;1865(8):158708. Epub 2020 Apr 10.

LIMES Institute Membrane Biology and Lipid Biochemistry, University Bonn, Germany. Electronic address:

Sphingosine-1-phosphate (S1P) is not only a catabolic intermediate of all sphingolipids but also an evolutionary conserved bioactive lipid with critical functions in cell survival, differentiation, and migration as well as in immunity and angiogenesis. S1P-lyase (SGPL1) irreversibly cleaves S1P in the final step of sphingolipid catabolism. As sphingoid bases and their 1-phosphates are not only metabolic intermediates but also highly bioactive lipids that modulate a wide range of physiological processes, it would be predicted that their elevation might induce adjustments in other facets of sphingolipid metabolism and/or alter cell behavior. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158708DOI Listing

The lipid composition of yeast cells modulates the response to iron deficiency.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 4;1865(8):158707. Epub 2020 Apr 4.

Departamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos (IATA), , Consejo Superior de Investigaciones Científicas (CSIC), Paterna, Valencia, Spain. Electronic address:

Iron is a vital micronutrient for all eukaryotes because it participates as a redox cofactor in multiple metabolic pathways, including lipid biosynthesis. In response to iron deficiency, the Saccharomyces cerevisiae iron-responsive transcription factor Aft1 accumulates in the nucleus and activates a set of genes that promote iron acquisition at the cell surface. In this study, we report that yeast cells lacking the transcription factor Mga2, which promotes the expression of the iron-dependent Δ9-fatty acid desaturase Ole1, display a defect in the activation of the iron regulon during the adaptation to iron limitation. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158707DOI Listing

Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Apr 1;1865(8):158706. Epub 2020 Apr 1.

Division of Biophysics, Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, Debrecen H-4032, Hungary. Electronic address:

As described in the literature the interaction between cholesterol and membrane proteins can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are mediated by alterations in the biophysical properties or in the protein-organizing functions of the lipid membrane. Early studies emphasized the importance of indirect and raft-mediated effects, but improvements in computational and structural imaging techniques allowed the definition of a wide range of functionally active cholesterol binding domains and sites suggesting the relevance of direct cholesterol effects in various proteins. However, the intramolecular rearrangements induced by cholesterol leading to modulation of ion channel gating, membrane transport and receptor functions still have not been revealed. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158706DOI Listing

The WD40 repeat protein, WDR36, orchestrates sphingosine kinase-1 recruitment and phospholipase C-β activation by G-coupled receptors.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 31;1865(7):158704. Epub 2020 Mar 31.

Institut für Allgemeine Pharmakologie und Toxikologie, Universitätsklinikum, Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Electronic address:

Sphingosine kinases (SphK) catalyse the formation of sphingosine-1-phosphate (S1P) and play important roles in the cardiovascular, nervous and immune systems. We have shown before that G-coupled receptors induce a rapid and long-lasting translocation of SphK1 to the plasma membrane and cross-activation of S1P receptors. Here, we further addressed G regulation of SphK1 by analysing the influence of the WD40 repeat protein, WDR36. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158704DOI Listing

4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Mar 31;1865(8):158705. Epub 2020 Mar 31.

Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX 79430-6551, USA.

Hemichannels formed by connexins mediate the exchange of ions and signaling molecules between the cytoplasm and the extracellular milieu. Under physiological conditions hemichannels have a low open probability, but in certain pathologies their open probability increases, which can result in cell damage. Pathological conditions are characterized by the production of a number of proinflammatory molecules, including 4-hydroxynonenal (4-HNE), one of the most common lipid peroxides produced in response to inflammation and oxidative stress. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158705DOI Listing

Rab7 controls lipid droplet-phagosome association during mycobacterial infection.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Mar 27;1865(8):158703. Epub 2020 Mar 27.

Laboratório de Imunofarmacologia, IOC, Fundação Oswaldo Cruz, Rio de Janeiro, 21045-900, RJ, Brazil. Electronic address:

Lipid droplets (LDs) are organelles that have multiple roles in inflammatory and infectious diseases. LD act as essential platforms for immunometabolic regulation, including as sites for lipid storage and metabolism, inflammatory lipid mediator production, and signaling pathway compartmentalization. Accumulating evidence indicates that intracellular pathogens may exploit host LDs as source of nutrients and as part of their strategy to promote immune evasion. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158703DOI Listing

Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Mar 25:158702. Epub 2020 Mar 25.

Institute of Pharmaceutical Chemistry/ZAFES, Max-von-Laue-Straße 9, Goethe University, 60438 Frankfurt/Main, Germany. Electronic address:

Macrophage polarization switches during the course of inflammation along with the lipid mediators released. We investigated the lipid mediator formation in human monocyte-derived macrophages during in vitro differentiation and pathogen stimulation. For this, peripheral blood monocytes were differentiated into M1 (CSF-2/IFNγ) or M2 (CSF-1/IL-4) macrophages followed by stimulation with the toll-like receptor (TLR) ligands zymosan (TLR-2), Poly(I:C) (TLR-3) or bacterial lipopolysaccharides (TLR-4) mimicking fungal, viral and bacterial infection, respectively. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158702DOI Listing

Carotenoid research: History and new perspectives for chemistry in biological systems.

Authors:
George Britton

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Mar 20:158699. Epub 2020 Mar 20.

University of Liverpool, School of Biological Sciences, Crown Street, Liverpool, L69 7ZB, United Kingdom. Electronic address:

The history of carotenoid research as this progressed from chemistry to biochemistry and biology is outlined. Proposed roles of carotenoids in eye health, as antioxidants, and in protection against cancer and other degenerative diseases, as well as stimulatory effects on the immune system and metabolism are covered. Proposed biological actions must be consistent with the chemistry of carotenoids in the largely aqueous biological systems, which may differ from the known chemistry of carotenoids in organic solvents. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158699DOI Listing

"Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice".

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 19;1865(7):158700. Epub 2020 Mar 19.

Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE, CICPBA-CONICET-UNLP), Calle 526, 10 y 11, La Plata 1900, Argentina; Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900, Argentina. Electronic address:

Spexin (SPX) is a novel adipokine related to many metabolic effects, such as gastrointestinal movements, insulin and glucose homeostasis, lipid metabolism and energy balance. This study evaluates the role of SPX in the improvement of the metabolic and inflammatory profile in fructose-rich-diet obese mice. Adult Swiss mice were supplemented or not with fructose (20% in tap water, FRD and CTR, respectively) for 10 weeks. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158700DOI Listing

A low level of lysophosphatidic acid in human gingival crevicular fluid from patients with periodontitis due to high soluble lysophospholipase activity: Its potential protective role on alveolar bone loss by periodontitis.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 13;1865(7):158698. Epub 2020 Mar 13.

Department of Pharmaceutical Health Chemistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Shomachi, Tokushima 770-8505, Japan; Department of Life Science, Faculty of Pharmacy, Yasuda Women's University, Hiroshima 730-0153, Japan. Electronic address:

We previously detected a submicromolar concentration of lysophosphatidic acid (LPA) in human saliva. Here, we compare LPA concentrations in human gingival crevicular fluid (GCF) from patients with periodontitis and healthy controls, and examine how the local LPA levels are regulated enzymatically. The concentrations of LPA and its precursor lysophospholipids in GCF was measured by liquid chromatography-tandem mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158698DOI Listing

Lysophospholipids and their receptors: New data and new insights into their function.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 13;1865(7):158697. Epub 2020 Mar 13.

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http://dx.doi.org/10.1016/j.bbalip.2020.158697DOI Listing

S1P and plasmalogen derived fatty aldehydes in cellular signaling and functions.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 12;1865(7):158681. Epub 2020 Mar 12.

Department of Pharmacology, University of Illinois, Chicago, IL, United States of America; Department of Medicine, University of Illinois, Chicago, IL, United States of America. Electronic address:

Long-chain fatty aldehydes are present in low concentrations in mammalian cells and serve as intermediates in the interconversion between fatty acids and fatty alcohols. The long-chain fatty aldehydes are generated by enzymatic hydrolysis of 1-alkyl-, and 1-alkenyl-glycerophospholipids by alkylglycerol monooxygenase, plasmalogenase or lysoplasmalogenase while hydrolysis of sphingosine-1-phosphate (S1P) by S1P lyase generates trans ∆2-hexadecenal (∆2-HDE). Additionally, 2-chloro-, and 2-bromo- fatty aldehydes are produced from plasmalogens or lysoplasmalogens by hypochlorous, and hypobromous acid generated by activated neutrophils and eosinophils, respectively while 2-iodofatty aldehydes are produced by excess iodine in thyroid glands. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214093PMC

Lysophosphatidylcholines inhibit human eosinophil activation and suppress eosinophil migration in vivo.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 11;1865(7):158686. Epub 2020 Mar 11.

Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Universitätsplatz 4, 8010 Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:

Eosinophils are important multifaceted effector cells involved in allergic inflammation. Following allergen challenge, eosinophils and other immune cells release secreted phospholipases, generating lysophosphatidylcholines (LPCs). LPCs are potent lipid mediators, and serum levels of LPCs associate with asthma severity, suggesting a regulatory activity of LPCs in asthma development. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158686DOI Listing
July 2020
5.162 Impact Factor

Advancements in understanding the role of lysophospholipids and their receptors in lung disorders including bronchopulmonary dysplasia.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 10;1865(7):158685. Epub 2020 Mar 10.

Department of Pediatrics, University of Illinois, Chicago, IL, United States of America; Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, IL, United States of America; Department of Pharmacology, University of Illinois, Chicago, IL, United States of America. Electronic address:

Bronchopulmonary dysplasia (BPD) is a devastating chronic neonatal lung disease leading to serious adverse consequences. Nearly 15 million babies are born preterm accounting for >1 in 10 births globally. The aetiology of BPD is multifactorial and the survivors suffer lifelong respiratory morbidity. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206974PMC

Induction of DEAD Box helicase 5 in early adipogenesis is regulated by Ten-eleven translocation 2.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 10;1865(7):158684. Epub 2020 Mar 10.

Department of Nutritional Science and Food Management, College of Science and Industry Convergence, Ewha Womans University, Seodaemoon-gu, Seoul 03760, Republic of Korea. Electronic address:

Dead box helicase 5 (DDX5) is an RNA helicase that is has cellular function on RNA splicing and transcriptional regulation. It has been reported to be involved in cell differentiation including adipogenesis. However, it is not clear how DDX5 is regulated during adipogenesis. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158684DOI Listing

Sterols as dietary markers for Drosophila melanogaster.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 10;1865(7):158683. Epub 2020 Mar 10.

MPI of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany. Electronic address:

During cold acclimation fruit flies switch their feeding from yeast to plant food, however there are no robust molecular markers to monitor this in the wild. Drosophila melanogaster is a sterol auxotroph and relies on dietary sterols to produce lipid membranes, lipoproteins and molting hormones. We employed shotgun lipidomics to quantify eight major food sterols in total lipid extracts of heads and genital tracts of adult male and female flies. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158683DOI Listing

VLDL/LDL serves as the primary source of cholesterol in the adrenal glucocorticoid response to food deprivation.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 10;1865(7):158682. Epub 2020 Mar 10.

Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, the Netherlands. Electronic address:

The contribution of individual lipoprotein species to the generation of the adrenal cholesterol pool used for the synthesis of anti-inflammatory glucocorticoid species remains unknown. Here we examined the impact of specific lowering of very low-density lipoprotein (VLDL) and low-density (LDL) levels on adrenal cholesterol and glucocorticoid homeostasis. Hereto, lethally-irradiated hypercholesterolemic apolipoprotein E (APOE) knockout mice received APOE-containing bone marrow from wild-type mice (n = 6) or APOE knockout control bone marrow (n = 10) and were subsequently fed a regular chow diet. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158682DOI Listing

A role of Gln596 in fine-tuning mammalian ALOX15 specificity, protein stability and allosteric properties.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 6;1865(7):158680. Epub 2020 Mar 6.

Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia. Electronic address:

His596 of human ALOX12 has been suggested to interact with the COO-group of arachidonic acid during ALOX catalysis. In mammalian ALOX15 orthologs Gln596 occupies this position and this amino acid exchange might contribute to the functional differences between the two ALOX-isoforms. To explore the role of Gln596 for ALOX15 functionality we mutated this amino acid to different residues in rabbit and human ALOX15 and investigated the impact of these mutations on structural, catalytic and allosteric enzyme properties. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158680DOI Listing

ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 6;1865(7):158679. Epub 2020 Mar 6.

Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Anatomy, University of Helsinki, Finland. Electronic address:

Loss-of-function (LOF) mutations in ANGPTL3, an inhibitor of lipoprotein lipase (LPL), cause a drastic reduction of serum lipoproteins and protect against the development of atherosclerotic cardiovascular disease. Therefore, ANGPTL3 is a promising therapy target. We characterized the impacts of ANGPTL3 depletion on the immortalized human hepatocyte (IHH) transcriptome, lipidome and human plasma lipoprotein lipidome. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158679DOI Listing

Suppression of long chain acyl-CoA synthetase blocks intracellular fatty acid flux and glucose uptake in skeletal myotubes.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 29;1865(7):158678. Epub 2020 Feb 29.

Department of Food and Nutrition, Daegu University, Gyeongsan 38453, South Korea. Electronic address:

Alterations in fatty acid metabolism are associated with impaired glucose uptake in skeletal muscle. Long-chain acyl-CoA synthetase (Acsl) 6 is the one of the Acsl isoforms expressed in skeletal muscle although its role in muscle energy metabolism has not been studied. Thus, the aims of this study were to investigate the role of Acsl6 in fatty acid partitioning and glucose uptake in differentiated skeletal myotubes using a siRNA-mediated knockdown approach. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158678DOI Listing

Promotion of plasmalogen biosynthesis reverse lipid changes in a Barth Syndrome cell model.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jun 29;1865(6):158677. Epub 2020 Feb 29.

Department of Biochemistry and Biomedical Sciences, McMaster University, Health Sciences Centre, Hamilton, Ontario L8S 4K1, Canada. Electronic address:

In Barth syndrome (BTHS) mutations in tafazzin leads to changes in both the quantities and the molecular species of cardiolipin (CL), which are the hallmarks of BTHS. Contrary to the well-established alterations in CL associated with BTHS; recently a marked decrease in the plasmalogen levels in Barth specimens has been identified. To restore the plasmalogen levels, the present study reports the effect of promotion of plasmalogen biosynthesis on the lipidome of lymphoblasts derived from Barth patients as well as on cell viability, mitochondria biogenesis, and mitochondrial membrane potential. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158677DOI Listing

Carotenoids and carotenoid conversion products in adipose tissue biology and obesity: Pre-clinical and human studies.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Feb 28:158676. Epub 2020 Feb 28.

Grup de Recerca Nutrigenòmica i Obesitat, Laboratori de Biologia Molecular, Nutrició i Biotecnologia (LBNB), Universitat de les Illes Balears, Palma de Mallorca, Spain; Institut d'Investigació Sanitària Illes Balears (IdISBa), Spain; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain.

Antiobesity activities of carotenoids and carotenoid conversion products (CCPs) have been demonstrated in pre-clinical studies, and mechanisms behind have begun to be unveiled, thus suggesting these compounds may help obesity prevention and management. The antiobesity action of carotenoids and CCPs can be traced to effects in multiple tissues, notably the adipose tissues. Key aspects of the biology of adipose tissues appear to be affected by carotenoid and CCPs, including adipogenesis, metabolic capacities for energy storage, release and inefficient oxidation, secretory function, and modulation of oxidative stress and inflammatory pathways. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158676DOI Listing
February 2020

Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jun 26;1865(6):158675. Epub 2020 Feb 26.

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

Ceramide kinase (CerK) phosphorylates ceramide to ceramide-1-phosphate (C1P), a bioactive sphingolipid. Since the mechanisms responsible for regulating the proliferation and migration/metastasis of cancer cells by the CerK/C1P pathway remain unclear, we conducted the present study. The knockdown of CerK in A549 lung and MCF-7 breast cancer cells (shCerK cells) increased the formation of lamellipodia, which are membrane protrusions coupled with cell migration. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158675DOI Listing

Retinoids in health and disease: A role for hepatic stellate cells in affecting retinoid levels.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jun 24;1865(6):158674. Epub 2020 Feb 24.

Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address:

Vitamin A (retinol) is important for normal growth, vision and reproduction. It has a role in the immune response and the development of metabolic syndrome. Most of the retinol present in the body is stored as retinyl esters within lipid droplets in hepatic stellate cells (HSCs). Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158674DOI Listing

Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jun 21;1865(6):158673. Epub 2020 Feb 21.

Leiden Academic Centre for Drug Research, Leiden, the Netherlands. Electronic address:

Patients with Atopic Dermatitis (AD) suffer from inflamed skin and skin barrier defects. Proper formation of the outermost part of the skin, the stratum corneum (SC), is crucial for the skin barrier function. In this study we analyzed the localization and activity of lipid enzymes β-glucocerebrosidase (GBA) and acid sphingomyelinase (ASM) in the skin of AD patients and controls. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158673DOI Listing

Carotenoid biofortification in crop plants: citius, altius, fortius.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Feb 15:158664. Epub 2020 Feb 15.

King Abdullah University of Science and Technology (KAUST), Division of Biological and Environmental Science and Engineering, Center for Desert Agriculture, the BioActives Lab, Thuwal 23955-6900, Saudi Arabia. Electronic address:

Carotenoids are indispensable for human health, required as precursors of vitamin A and efficient antioxidants. However, these plant pigments that play a vital role in photosynthesis are represented at insufficient levels in edible parts of several crops, which creates a need for increasing their content or optimizing their composition through biofortification. In particular, vitamin A deficiency, a severe health problem affecting the lives of millions in developing countries, has triggered the development of a series of high-provitamin A crops, including Golden Rice as the best-known example. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158664DOI Listing
February 2020