PRDM14, a putative histone methyl-transferase, interacts with and decreases the stability and activity of the HOXA1 transcription factor.
- Amandine Draime,
- Laure Bridoux,
- Magali Belpaire,
- Tamara Pringels,
- Janne Tys,
- René Rezsohazy
Biochim Biophys Acta 2018 Feb 19. Epub 2018 Feb 19.
Animal Molecular and Cellular Biology Group, Institut des Sciences de la Vie (ISV), Université catholique de Louvain, Croix du Sud 5, 1348 Louvain-la-Neuve, Belgium. Electronic address:
Understanding how the activity of transcription factors like HOX proteins is regulated remains a widely open question. In a recent screen for proteins interacting with HOXA1, we identified a PRDM protein family member, PRDM14, which is known to be transiently co-expressed with HOXA1 in epiblast cells before their specification towards somatic versus germ cell fate. Here, we confirm PRDM14 is an interactor of HOXA1 and we identify the homeodomain of HOXA1 as well as the PR domain and Zinc fingers of PRDM14 to be required for the interaction. Read More