102,231 results match your criteria Biochimica et Biophysica Acta[Journal]


RhoC/ROCK2 promotes vasculogenic mimicry formation primarily through ERK/MMPs in hepatocellular carcinoma.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 16. Epub 2019 Feb 16.

Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai 200080, PR China. Electronic address:

Vasculogenic mimicry (VM) results in the formation of an alternative circulatory system that can improve the blood supply to multiple malignant tumors, including hepatocellular carcinoma (HCC). However, the potential mechanisms of RhoC/ROCK in VM have not yet been investigated in HCC. Here, RhoC expression was upregulated in HCC tissues, especially the VM-positive (VM+) group, compared to noncancerous tissues (P < 0. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.12.007DOI Listing
February 2019

Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 15. Epub 2019 Feb 15.

Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, the Netherlands.

The nuclear receptor liver X receptor (LXR) impacts on cholesterol metabolism as well as hepatic lipogenesis via transcriptional regulation. It is proposed that inhibition of the protein arginine methyltransferase 3 (PRMT3) uncouples these two transcriptional pathways in vivo by acting as a specific lipogenic coactivator of LXR. Here we validated the hypothesis that treatment with the allosteric PRMT3 inhibitor SGC707 will diminish the hepatic steatosis extent, while leaving global cholesterol metabolism, important in cholesterol-driven pathologies like atherosclerosis, untouched. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.012DOI Listing
February 2019

The potential contribution of stromal cell-derived factor 2 (SDF2) in endoplasmic reticulum stress response in severe preeclampsia and labor-onset.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 15. Epub 2019 Feb 15.

Institute of Biomedical Sciences, Department of Cell and Developmental Biology, University of São Paulo, São Paulo, SP, Brazil. Electronic address:

Endoplasmic reticulum (ER) stress occurs when the protein folding machinery in the cell is unable to cope with newly synthesized proteins, which results in an accumulation of misfolded proteins in the ER lumen. In response, the cell activates a cellular signaling pathway known as the Unfolded Protein Response (UPR), aiming to restore cellular homeostasis. Activation and exacerbation of the UPR have been described in several human pathologies, including cancer and neurological disorders, and in some gestational diseases such as preeclampsia and gestational diabetes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.012DOI Listing
February 2019

Many ways to resistance: How melanoma cells evade targeted therapies.

Biochim Biophys Acta Rev Cancer 2019 Feb 15. Epub 2019 Feb 15.

Life Sciences Research Unit, University of Luxembourg, 6, avenue du Swing, L-4367 Belvaux, Luxembourg. Electronic address:

Melanoma is an aggressive malignancy originating from pigment-producing melanocytes. The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies (immune checkpoint inhibitors) led to a substantial improvement in overall survival of patients. However, the long-term efficacy of such treatments is limited by side effects, lack of clinical effects and the rapidly emerging resistance to treatment. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.02.002DOI Listing
February 2019

Rsp5-dependent endocytosis and degradation of the arsenite transporter Acr3 requires its N-terminal acidic tail as an endocytic sorting signal and arrestin-related ubiquitin-ligase adaptors.

Biochim Biophys Acta Biomembr 2019 Feb 15. Epub 2019 Feb 15.

Institute of Experimental Biology, University of Wroclaw, 50-328 Wroclaw, Poland. Electronic address:

The yeast plasma membrane transporter Acr3 mediates efflux of toxic arsenite and antimonite. Here, we investigated the mechanisms of Acr3 turnover. We found that after arrival and residence at the plasma membrane, Acr3 is subjected to internalization followed by proteolysis in the vacuole. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.02.004DOI Listing
February 2019

Assemblies of lauryl maltose neopentyl glycol (LMNG) and LMNG-solubilized membrane proteins.

Biochim Biophys Acta Biomembr 2019 Feb 15. Epub 2019 Feb 15.

Univ. Grenoble Alpes, CNRS, CEA, Institute for Structural Biology (IBS), 38000 Grenoble, France. Electronic address:

Laurylmaltose neopentylglycol (LMNG) bears two linked hydrophobic chains of equal length and two hydrophilic maltoside groups. It arouses a strong interest in the field of membrane protein biochemistry, since it was shown to efficiently solubilize and stabilize membrane proteins often better than the commonly used dodecylmaltopyranoside (DDM), and to allow structure determination of some challenging membrane proteins. However, LMNG was described to form large micelles, which could be unfavorable for structural purposes. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.02.003DOI Listing
February 2019
3.836 Impact Factor

Binding of a Naja naja venom acidic phospholipase A cognate complex to membrane-bound vimentin of rat L6 cells: Implications in cobra venom-induced cytotoxicity.

Biochim Biophys Acta Biomembr 2019 Feb 15. Epub 2019 Feb 15.

Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, Assam, India. Electronic address:

An acidic phospholipase A enzyme (NnPLA-I) interacts with three finger toxins (cytotoxin and neurotoxin) from Naja naja venom to form cognate complexes to enhance its cytotoxicity towards rat L6 myogenic cells. The cytotoxicity was further enhanced in presence of trace quantity of venom nerve growth factor. The purified rat myoblast cell membrane protein showing interaction with NnPLA-I was identified as vimentin by LC-MS/MS analysis. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.02.002DOI Listing
February 2019

Structure determination of UL49.5 transmembrane protein from bovine herpesvirus 1 by NMR spectroscopy and molecular dynamics.

Biochim Biophys Acta Biomembr 2019 Feb 14. Epub 2019 Feb 14.

Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland. Electronic address:

The transporter associated with antigen processing (TAP) directly participates in the immune response as a key component of the cytosolic peptide to major histocompatibility complex (MHC) class I protein loading machinery. This makes TAP an important target for viruses avoiding recognition by CD8+ T lymphocytes. Its activity can be suppressed by the UL49. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.02.005DOI Listing
February 2019

Corrigendum to quantitative NMR study of heat-induced aggregation of eye-lens crystallin proteins under crowding conditions. BBAPAP Volume 1866/10 2018 1055-1061].

Biochim Biophys Acta Proteins Proteom 2019 Feb 13. Epub 2019 Feb 13.

Institut für Physik, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle (Saale), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2019.02.001DOI Listing
February 2019

FMRpolyG alters mitochondrial transcripts level and respiratory chain complex assembly in Fragile X associated tremor/ataxia syndrome [FXTAS].

Biochim Biophys Acta Mol Basis Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry, Faculty of Science, The M.S. University of Baroda, Vadodara 390002, Gujarat, India. Electronic address:

Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder caused by an expansion of 55 to 200 CGG repeats (premutation) in FMR1. These CGG repeats are Repeat Associated non-ATG (RAN) translated into a small and pathogenic protein, FMRpolyG. The cellular and molecular mechanisms of FMRpolyG toxicity are unclear. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.010DOI Listing
February 2019

SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy; Infertility Service, San Salvatore Hospital, L'Aquila 67100, L'Aquila, Italy. Electronic address:

Methylglyoxal (MG), a highly reactive dicarbonyl derived from metabolic processes, is the most powerful precursor of advanced glycation end products (AGEs). Glycative stress has been recently associated with ovarian dysfunctions in aging and PCOS syndrome. We have investigated the role of the NAD-dependent Class III deacetylase SIRT1 in the adaptive response to MG in mouse oocytes and ovary. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.011DOI Listing
February 2019

RLIP: An existential requirement for breast carcinogenesis.

Biochim Biophys Acta Rev Cancer 2019 Feb 13;1871(2):281-288. Epub 2019 Feb 13.

Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Breast cancer (BC) is the most common cancer among women worldwide. Due to its complexity in nature, effective BC treatment can encounter many challenges. The human RALBP1 gene encodes a 76-kDa splice variant protein, RLIP (ral-binding protein1, RalBP1), a stress-protective mercapturic acid pathway (MAP) transporter protein, that also plays a key role in regulating clathrin-dependent endocytosis (CDE) as a Ral effector. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.02.001DOI Listing
February 2019

BAG3 deletion suppresses stem cell-like features of pancreatic ductal adenocarcinoma via translational suppression of ISG15.

Biochim Biophys Acta Mol Cell Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry & Molecular Biology, China Medical University, Shenyang 110122, China; Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, China. Electronic address:

BAG3 is a member of the cochaperone BAG family and often highly expressed in various cancers. Recently, evidences show that BAG3 promotes stemness of human cancer cells. IFN-stimulated genes 15 (ISG15) is an ubiquitin-like molecule, which is covalently conjugated with substrates to form ISGylated proteins. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.008DOI Listing
February 2019

Lysosomal regulation of extracellular vesicle excretion during d-ribose-induced NLRP3 inflammasome activation in podocytes.

Biochim Biophys Acta Mol Cell Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, United States of America. Electronic address:

The NLRP3 inflammasome is activated in the cytoplasm of cells and its products such as IL-1β are exported through a non-classical ER-Golgi pathway. Several mechanistically distinct models including exocytosis of secretory lysosomes, microvesicles (MVs) and extracellular vehicles (EVs) have been proposed for their release. In this study, we hypothesized that the NLRP3 inflammasome product, IL-1β in response to exogenously administrated and endogenously produced d-ribose stimulation is released via extracellular vesicles including EVs via a sphingolipid-mediated molecular mechanisms controlling lysosome and multivesicular body (MVB) interaction. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.007DOI Listing
February 2019

DENN domain-containing protein FAM45A regulates the homeostasis of late/multivesicular endosomes.

Biochim Biophys Acta Mol Cell Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou, Jiangsu 215123, China. Electronic address:

DENN (differentially expressed in normal cells and neoplasia) domain-containing proteins are a family of guanine nucleotide exchange factors (GEFs) for Rab small GTPases and coordinate a plethora of intracellular membrane trafficking events. FAM45A is a non-classical DENN domain protein, whose function was unknown. In this study, we characterized cellular roles of FAM45A. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.006DOI Listing
February 2019

Intrinsic origin of amyloid aggregation: Behavior of histidine (εεε) and (δδδ) tautomer homodimers of Aβ (1-40).

Biochim Biophys Acta Gen Subj 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, Sungkyunkwan University, Suwon 16419, South Korea; School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China. Electronic address:

Amyloid-beta protein (Aβ) accumulation in the brain, which is influenced by several factors, is a hallmark of Alzheimer's disease (AD). Despite the important role of histidine in stabilizing the fibrillar structure of the Aβ peptide at neutral pH, the effect of histidine tautomerism on Aβ peptide aggregation is still largely unknown. Histidine is in equilibrium between δ and ε tautomers and there are three histidine residues (H6, H13, and H14) in the Aβ(1-40) peptide. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.007DOI Listing
February 2019

Variations in carotenoid content and acyl chain composition in exponential, stationary and biofilm states of Staphylococcus aureus, and their influence on membrane biophysical properties.

Biochim Biophys Acta Biomembr 2019 Feb 13. Epub 2019 Feb 13.

Department of Physics, Universidad de los Andes, Bogotá, Colombia. Electronic address:

Bacteria are often found in close association with surfaces, resulting in the formation of biofilms. In Staphylococcus aureus (S. aureus), biofilms are implicated in the resilience of chronic infections, presenting a serious clinical problem world-wide. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.02.001DOI Listing
February 2019

CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: Novel microglial models for X-linked Adrenoleukodystrophy.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Feb 12. Epub 2019 Feb 12.

Laboratoire Bio-PeroxIL EA7270, University of Bourgogne Franche-Comté, Dijon, France. Electronic address:

X-linked adrenoleukodystrophy (X-ALD), the most frequent peroxisomal disorder, is associated with mutation in the ABCD1 gene which encodes a peroxisomal ATP-binding cassette transporter for very long-chain fatty acids (VLCFA). The biochemical hallmark of the disease is the accumulation of VLCFA. Peroxisomal defect in microglia being now considered a priming event in the pathology, we have therefore generated murine microglial cells mutated in the Abcd1 gene and its closest homolog, the Abcd2 gene. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.02.006DOI Listing
February 2019

Novel functions of phospholipase As: Overview.

Authors:
Makoto Murakami

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; AMED-CREST, Japan Agency for Medical Research and Development, 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2019.02.005DOI Listing
February 2019

PKA negatively modulates the migration enhancing effect of Connexin 43.

Biochim Biophys Acta Mol Cell Res 2019 Feb 12. Epub 2019 Feb 12.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München and Munich University Hospital, Großhaderner Str. 9, 82152 Planegg, Martinsried, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Biedersteiner Str. 29, 80802 München, Germany. Electronic address:

Connexin 43 (Cx43) expression is associated with an increased cell migration and related changes of the actin cytoskeleton (enhanced filopodia formation). These effects are mediated by the C-terminal cytoplasmic part of Cx43 in a channel-independent manner. Since this part has been shown to interact with a variety of proteins and has multiple phosphorylation sites we analyzed here a potential role of the protein kinase A (PKA) for the Cx43 mediated increase in cell migration. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.001DOI Listing
February 2019

Involvement of Caveolin-1 and CD36 in native LDL endocytosis by endothelial cells.

Biochim Biophys Acta Gen Subj 2019 Feb 12. Epub 2019 Feb 12.

Institute of Chemistry and Biology of Membranes and Nano-objects (CBMN), UMR 5248, CNRS, University of Bordeaux, INP, F-33600 Pessac, France.

Atherosclerosis is a lipid disease characterized by accumulation of low density lipoprotein (LDL) in the artery wall. The transport of LDL across the endothelium of coronary artery is an initiating event of atherosclerosis, whose mechanism remains poorly understood. In the last decade, it has been shown that in caveolin-1 (Cav-1) deficient mice, LDL infiltration in aorta wall is decreased and CD36 expression in aortas is down-regulated, leading to regression of atherosclerotic lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03044165193000
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http://dx.doi.org/10.1016/j.bbagen.2019.01.005DOI Listing
February 2019
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A multidimensional concept for mercury neuronal and sensory toxicity in fish - from toxicokinetics and biochemistry to morphometry and behavior.

Biochim Biophys Acta Gen Subj 2019 Feb 12. Epub 2019 Feb 12.

Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Background: Neuronal and sensory toxicity of mercury (Hg) compounds has been largely investigated in humans/mammals with a focus on public health, while research in fish is less prolific and dispersed by different species. Well-established premises for mammals have been governing fish research, but some contradictory findings suggest that knowledge translation between these animal groups needs prudence [e.g. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.01.020DOI Listing
February 2019
4.381 Impact Factor

Regulatory effect of host miR-101b-3p on parasitism of nematode Angiostrongylus cantonensis via superoxide dismutase 3.

Biochim Biophys Acta Gene Regul Mech 2019 Feb 11. Epub 2019 Feb 11.

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory for Tropical Diseases Control (SYSU), Ministry of Education, Guangzhou 510080, China; Provincial Engineering Technology Research Center for Diseases-vectors Control, Guangdong, Guangzhou 510080, China. Electronic address:

MicroRNA plays a vital role in the regulation of host-parasite interaction. In recent years, genomic and transcriptomic resources have become increasingly available for many helminths, but only a limited number of reports in this area are on the regulatory effects of host microRNAs on parasitic nematodes. In this work, we screened increased expression of host microRNAs after nematode infection from miRNA-seq data and predicted target genes by combined bioinformatics analysis and transcriptional profiling. Read More

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http://dx.doi.org/10.1016/j.bbagrm.2019.02.004DOI Listing
February 2019

Two mechanisms involving the autophagic and proteasomal pathways process the metastasis suppressor protein, N-myc downstream regulated gene 1.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 11. Epub 2019 Feb 11.

Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute, Medical Foundation Building (K25), University of Sydney, Sydney, New South Wales 2006, Australia; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. Electronic address:

N-myc downstream regulated gene 1 (NDRG1) is an intriguing metastasis suppressor protein, which plays an important role in suppressing multiple oncogenic signaling pathways. Interestingly, multiple isoforms of NDRG1 have been identified, although the molecular mechanisms involved in their generation remains elusive. Herein, we demonstrate the role of two mechanisms involving autophagic and proteasomal machinery as part of an intricate system to generate different NDRG1 isoforms. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.008DOI Listing
February 2019

Lysophosphatidic acid receptor 1 inhibitor, AM095, attenuates diabetic nephropathy in mice by downregulation of TLR4/NF-κB signaling and NADPH oxidase.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 11. Epub 2019 Feb 11.

College of Pharmacy, Gachon University, Incheon, Republic of Korea; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea; Gachon University Gil Medical Center, Gachon Medical and Convergence Institute, Incheon, Republic of Korea. Electronic address:

Diabetic nephropathy (DN) is one of the major long-term complications of diabetes. Lysophosphatidic acid (LPA) signaling has been implicated in renal fibrosis. In our previous study, we found that the LPA receptor 1/3 (LPAR1/3) antagonist, ki16425, protected against DN in diabetic db/db mice. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.001DOI Listing
February 2019

Regulation of permeability transition pore opening in mitochondria by external NAD(H).

Biochim Biophys Acta Gen Subj 2019 Feb 11. Epub 2019 Feb 11.

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, Pushchino, Moscow Region 142290, Russia. Electronic address:

Background: The opening of the permeability transition pore (PTP) in mitochondria plays a critical role in the pathogenesis of numerous diseases. Mitochondrial matrix pyridine nucleotides are potent regulators of the PTP, but the role of extramitochondrial nucleotides is unclear.

Methods: The PTP opening was explored in isolated mitochondria and mitochondria in permeabilized differentiated and undifferentiated cells in the presence of added NAD(P)(H) in combination with Mg, adenine nucleotides (AN), and the inhibitors of AN translocase (ANT), voltage-dependent anion channel (VDAC), and cyclophilin D. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.01.003DOI Listing
February 2019

AFM study: Cell cycle and probe geometry influences nanomechanical characterization of Panc1 cells.

Biochim Biophys Acta Gen Subj 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry and Molecular Biology, Mayo College of Medicine and Science, Jacksonville, FL, USA; Department of Pathology and Biomedical Engineering, Mayo College of Medicine and Science, Jacksonville, FL, USA. Electronic address:

Atomic force microscope (AFM) is emerging as an immensely promising tool to study the cellular morphology with a nanometer scale resolution and to analyze nanomechanical properties (NPs) at various physiological conditions. Advancement of AFM technology enables studying living cells and differentiating cancer cell from normal cells based on topography and NPs. Though the trend overlaps from different literature; numerical values of nanomechanical readouts depict variations over a wide range. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.006DOI Listing
February 2019

Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment ("chemobrain"), a condition that significantly impairs the quality of life of many cancer survivors.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 10. Epub 2019 Feb 10.

Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

Increasing numbers of cancer patients survive and live longer than five years after therapy, but very often side effects of cancer treatment arise at same time. One of the side effects, chemotherapy-induced cognitive impairment (CICI), also called "chemobrain" or "chemofog" by patients, brings enormous challenges to cancer survivors following successful chemotherapeutic treatment. Decreased abilities of learning, memory, attention, executive function and processing speed in cancer survivors with CICI, are some of the challenges that greatly impair survivors' quality of life. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.007DOI Listing
February 2019

Embryonic programming of heart disease in response to obesity during pregnancy.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 10. Epub 2019 Feb 10.

Translational Medicine, The Hospital for Sick Children, Toronto M5G0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5S1A8, Canada; Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto M5S3H2, Canada. Electronic address:

Obesity during pregnancy programs adult-onset heart disease in the offspring. Clinical studies indicate that exposure to an adverse environment in utero during early, as compared to late, gestation leads to a higher prevalence of adult-onset heart disease. This suggests that the early developing heart is particularly sensitive to an adverse environment. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.028DOI Listing
February 2019
4.882 Impact Factor

5' processing of Saccharomyces cerevisiae mitochondrial tRNAs requires expression of multiple genes.

Biochim Biophys Acta Mol Cell Res 2019 Feb 10. Epub 2019 Feb 10.

Departamento de Microbiologia - Instituto de Ciências Biomédicas, University of São Paulo, São Paulo, Brazil. Electronic address:

Mitochondrial tRNAs are processed at their 5'ends by highly divergent but ubiquitous RNase P. In Saccharomyces cerevisiae, Rpm2p is the protein component of RNase P. Here, we identify four novel genes MTA1, MTA2, GEP5 and PET130 of the Saccharomycetaceae family that are necessary for an efficient processing of mitochondrial tRNAs. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.002DOI Listing
February 2019

Rice Trithorax factor ULTRAPETALA 1 (OsULT1) specifically binds to "GAGAG" sequence motif present in Polycomb response elements.

Biochim Biophys Acta Gene Regul Mech 2019 Feb 9. Epub 2019 Feb 9.

Division of Plant Biology, Bose Institute, Kolkata 700054, India. Electronic address:

Co-ordinated interplay between Polycomb group (PcG) and Trithorax group (TrxG) of proteins regulate chromatin state and maintain the transcription "off" and "on" state of a gene in higher eukaryotes. Targeting PcG complex to a specific locus is mediated by DNA sequences known as Polycomb response elements. Interestingly, these PREs are also recognized by TrxG proteins to antagonise PcG mediated gene repression. Read More

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http://dx.doi.org/10.1016/j.bbagrm.2019.02.001DOI Listing
February 2019
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MiR-15/16 mediate crosstalk between the MAPK and Wnt/β-catenin pathways during hepatocyte differentiation from amniotic epithelial cells.

Biochim Biophys Acta Gene Regul Mech 2019 Feb 9. Epub 2019 Feb 9.

Key Laboratory of Precision Oncology of Shandong Higher Education, Institute of precision medicine, Jining Medical University, Jining, Shandong 272067, PR China; College of Basic Medicine, Jining Medical University, Jining, Shandong 272067, PR China; Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China. Electronic address:

MiR-15/16 play an important role in liver development and hepatocyte differentiation, but the mechanisms by which these miRNAs regulate their targets and downstream genes to influence cell fate are poorly understood. In this study, we showed up-regulation of miR-15/16 during HGF- and FGF4-induced hepatocyte differentiation from amniotic epithelial cells (AECs). To elucidate the role of miR-15/16 and their targets in hepatocyte differentiation, we investigated the roles of miR-15/16 in both the MAPK and Wnt/β-catenin pathways, which were predicted to be involved in miR-15/16 signaling. Read More

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http://dx.doi.org/10.1016/j.bbagrm.2019.02.003DOI Listing
February 2019
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Generation of induced pluripotent stem cells using elastin like polypeptides as a non-viral gene delivery system.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 9. Epub 2019 Feb 9.

Department of Chemical Engineering, Texas Tech University, 8th and Canton, Lubbock, TX 79409, United States. Electronic address:

Induced pluripotent stem cells (iPSCs) have been generated from various somatic cells using different approaches; however, a major restriction of reprogramming methods is the use of viral vectors, which have the risk of causing genome-integration of viral DNA. Here, without a viral vector, we generated iPSCs from mouse fibroblasts using an elastin-like polypeptide (ELP)-based transfection method. Our findings support the possible use of ELPs for delivery of the reprogramming genes in to somatic cells for generation of iPSCs. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.031DOI Listing
February 2019

LPS promotes HBO1 stability via USP25 to modulate inflammatory gene transcription in THP-1 cells.

Biochim Biophys Acta Gene Regul Mech 2018 Sep 4;1861(9):773-782. Epub 2018 Aug 4.

Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA 15213.

The histone acetyltransferase HBO1 (Histone acetyltransferase binding to origin recognition complex 1, Myst2/Kat7) participates in a range of life processes including DNA replication and tumorigenesis. Recent studies revealed that HBO1 is involved in gene transcriptional activation. However, the molecular behavior of HBO1 in inflammation is yet to be studied. Read More

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http://dx.doi.org/10.1016/j.bbagrm.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368258PMC
September 2018

Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose consumption.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 8. Epub 2019 Feb 8.

Department of Endocrinology, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Medical College, Yangzhou University, Yangzhou 225001, China.

Overweight and obesity may cause several metabolic complications, including type 2 diabetes mellitus and hyperlipidemia. Despite years of progress in medicine, there are no highly effective pharmacological treatments for obesity. The natural compound celastrol, a pentacyclic triterpene extracted from the roots of Tripterygium Wilfordi (thunder god vine) plant, exerts various bioactivities including anti-diabetic and anti-obese effects. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.002DOI Listing
February 2019
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Impact of apolipoprotein A1- or lecithin:cholesterol acyltransferase-deficiency on white adipose tissue metabolic activity and glucose homeostasis in mice.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 10. Epub 2019 Feb 10.

University of Patras, School of Medicine, Department of Pharmacology, Rio, Achaias, TK. 26500, Greece. Electronic address:

High density lipoprotein (HDL) has attracted the attention of biomedical community due to its well-documented role in atheroprotection. HDL has also been recently implicated in the regulation of islets of Langerhans secretory function and in the etiology of peripheral insulin sensitivity. Indeed, data from numerous studies strongly indicate that the functions of pancreatic β-cells, skeletal muscles and adipose tissue could benefit from improved HDL functionality. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.003DOI Listing
February 2019
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Human-induced pluripotent stems cells as a model to dissect the selective neurotoxicity of methylmercury.

Biochim Biophys Acta Gen Subj 2019 Feb 10. Epub 2019 Feb 10.

School of Health Sciences, Purdue University, West Lafayette, IN 47907-2051, United States. Electronic address:

Methylmercury (MeHg) is a potent neurotoxicant affecting both the developing and mature central nervous system (CNS) with apparent indiscriminate disruption of multiple homeostatic pathways. However, genetic and environmental modifiers contribute significant variability to neurotoxicity associated with human exposures. MeHg displays developmental stage and neural lineage selective neurotoxicity. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.002DOI Listing
February 2019
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Variation in the biological half-life of methylmercury in humans: Methods, measurements and meaning.

Biochim Biophys Acta Gen Subj 2019 Feb 8. Epub 2019 Feb 8.

Husson University, School of Pharmacy, Bangor, ME 04401, United States.

Background: Understanding methylmercury (MeHg) toxicity requires a complete understanding of its fundamental toxicokinetic and toxicodynamic characteristics in the human body. The biological half-life (t) of MeHg is a kinetic property that directly influences the body burden of Hg that results from repeated exposures such as can occur with fish and seafood consumption. The t of MeHg in humans is approximately 50 days, equivalent to an elimination rate (k) of 0. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.003DOI Listing
February 2019
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Mercury-induced inflammation and autoimmunity.

Biochim Biophys Acta Gen Subj 2019 Feb 8. Epub 2019 Feb 8.

Department of Immunology and Microbiology, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, 92037, United States of America. Electronic address:

Background: Human exposure to mercury leads to a variety of pathologies involving numerous organ systems including the immune system. A paucity of epidemiological studies and suitable diagnostic criteria, however, has hampered collection of sufficient data to support a causative role for mercury in autoimmune diseases. Nevertheless, there is evidence that mercury exposure in humans is linked to markers of inflammation and autoimmunity. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.001DOI Listing
February 2019
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Direct observation of alpha-lactalbumin interaction, adsorption and incorporation with lipid membrane and formation of lipid/protein hybrid structures.

Biochim Biophys Acta Gen Subj 2019 Feb 8. Epub 2019 Feb 8.

Dipartimento di Fisica e Chimica, Università di Palermo, 90128 Palermo, Italy. Electronic address:

The interaction between proteins and membranes is of great interest in biomedical and biotechnological research for its implication in many functional and dysfunctional processes. We present an experimental study on the interaction between model membranes and alpha-lactalbumin (α-La). α-La is widely studied for both its biological function and its anti-tumoral properties. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.005DOI Listing
February 2019
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Periostin/β1integrin interaction regulates p21-activated kinases in valvular interstitial cell survival and in actin cytoskeleton reorganization *¶.

Biochim Biophys Acta Gen Subj 2019 Feb 8. Epub 2019 Feb 8.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.. Electronic address:

The matricellular protein periostin (PN) promotes postnatal valve remodeling and maturation. Incomplete remodeling of the valve can trigger degenerative processes that lead to a myxomatous phenotype that includes loss of PN. However, signaling pathways involved that link valvular-interstitial-fibroblast cells (VICs) to proliferation, migration and actin remodeling functions are unclear. Read More

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http://dx.doi.org/10.1016/j.bbagen.2018.12.015DOI Listing
February 2019
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HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway.

Biochim Biophys Acta Mol Cell Res 2019 Feb 8;1866(5):750-760. Epub 2019 Feb 8.

College of Laboratory Medicine, Dalian Medical University, Dalian 116044, Liaoning Province, China. Electronic address:

Metastasis is the main cause of death in colorectal cancer (CRC) patients. Aberrant fucosylation, catalyzed by the specific fucosyltransferases (FUTs), is associated with malignant behaviors. Non-conding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), emerge as key molecules in cancer malignancy. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.004DOI Listing
February 2019
5.019 Impact Factor

Mix and (mis-)match - The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart.

Biochim Biophys Acta Mol Cell Res 2019 Feb 8. Epub 2019 Feb 8.

Division of Bioengineering, School of Engineering and Materials Science & Institute for Bioengineering, Queen Mary University of London, United Kingdom. Electronic address:

The composition and the stiffness of cardiac microenvironment change during development and/or in heart disease. Cardiomyocytes (CMs) and their progenitors sense these changes, which decides over the cell fate and can trigger CM (progenitor) proliferation, differentiation, de-differentiation or death. The field of mechanobiology has seen a constant increase in output that also includes a wealth of new studies specific to cardiac or cardiomyocyte mechanosensing. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.01.017DOI Listing
February 2019
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Phosphatidylinositol-3-phosphate-mediated actin domain formation linked to DNA synthesis upon insulin treatment in rat hepatoma-derived H4IIEC3 cells.

Biochim Biophys Acta Mol Cell Res 2019 Feb 8. Epub 2019 Feb 8.

Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8503, Japan; Laboratory of Frontier Image Analysis, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. Electronic address:

Phosphatidylinositol-3-phosphate (PI3P) is a lipid that accumulates in the early endosomal membrane, and acts as a scaffold to recruit proteins that contain a PI3P-binding domain, such as the FYVE domain. In this study, we examined the effect of PI3P depletion on the insulin response in rat hepatoma-derived H4IIEC3 cells. We found that insulin treatment induced the transient formation of an actin domain structure, a mesh-like tangled network of actin filaments where phosphorylated Akt, endosomal proteins, and PI3P accumulated. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.005DOI Listing
February 2019

Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Feb 8. Epub 2019 Feb 8.

Center for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:

Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipodystrophy (FPLD), to a total absence of metabolically active AT in congenital generalized lipodystrophy (CGL) and is generally associated with the severity of metabolic complications. Significant genetic, allelic, phenotypic, and clinical heterogeneity exists among the lipodystrophies. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.02.002DOI Listing
February 2019
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Interaction of salt with ether- and ester-linked phospholipid bilayers.

Biochim Biophys Acta Biomembr 2019 Feb 8;1861(5):907-915. Epub 2019 Feb 8.

Department of Physics, University of South Florida, Tampa, FL 33620, United States of America. Electronic address:

A distinguishing feature of Archaeal plasma membranes is that their phospholipids contain ether-links, as opposed to bacterial and eukaryotic plasma membranes where phospholipids primarily contain ester-links. Experiments show that this chemical difference in headgroup-tail linkage does produce distinct differences in model bilayer properties. Here we examine the effects of salt on bilayer structure in the case of an ether-linked lipid bilayer. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.01.016DOI Listing
February 2019

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Biochim Biophys Acta Gen Subj 2019 Feb 7;1863(4):742-748. Epub 2019 Feb 7.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom. Electronic address:

Background: The β-lactam antibiotics represent the most successful drug class for treatment of bacterial infections. Resistance to them, importantly via production of β-lactamases, which collectively are able to hydrolyse all classes of β-lactams, threatens their continued widespread use. Bicyclic boronates show potential as broad spectrum inhibitors of the mechanistically distinct serine- (SBL) and metallo- (MBL) β-lactamase families. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.004DOI Listing
February 2019
2 Reads

Hypothalamic expression of the atypical chemokine receptor ACKR2 is involved in the systemic regulation of glucose tolerance.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 7. Epub 2019 Feb 7.

Laboratory of Cell Signaling, University of Campinas, 13083-865 Campinas, SP, Brazil; Obesity and Comorbidities research Center, University of Campinas, 13083-865 Campinas, SP, Brazil. Electronic address:

In experimental obesity, the hypothalamus is affected by an inflammatory response activated by dietary saturated fats. This inflammation is triggered as early as one day after exposure to a high-fat diet, and during its progression, there is recruitment of inflammatory cells from the systemic circulation. The objective of the present study was identifying chemokines potentially involved in the development of hypothalamic diet-induced inflammation. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.001DOI Listing
February 2019

Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 7. Epub 2019 Feb 7.

INRS-Institut Armand-Frappier, Université du Québec and Biomed Research Center, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada; Center for Interdisciplinary Research on Well-Being, Health, Society and Environment, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.

Serotonin (5-hydroxytryptamine, 5-HT) regulates diverse physiological and behavioural and processes, also acts as a developmental signal in early embryogenesis and in regulation of fetal development. A number of studies have implicated the prominent role of serotonin transporter (SERT or 5-HTT) and 5-HT receptor subtypes in placental development and function. Here, in this article we have provided a comprehensive review on the important role of 5-HT homeostasis in pregnancy outcomes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.017DOI Listing
February 2019
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The M-band: The underestimated part of the sarcomere.

Biochim Biophys Acta Mol Cell Res 2019 Feb 7. Epub 2019 Feb 7.

Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK; School of Cardiovascular Medicine and Sciences, British Heart Foundation Research Excellence Centre, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK. Electronic address:

The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and associated proteins) and thick (myosin and associated proteins) filaments to the elastic filament system composed of titin. A plethora of proteins are known to be integral or associated proteins of the Z-disc and its structural and signalling role in muscle is better understood, while the molecular constituents of the M-band and its function are less well defined. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.003DOI Listing
February 2019