1,202 results match your criteria Biochimica Et Biophysica Acta-molecular Basis Of Disease[Journal]


Osteoclast signaling-targeting miR-146a-3p and miR-155-5p are downregulated in Paget's disease of bone.

Biochim Biophys Acta Mol Basis Dis 2020 May 30:165852. Epub 2020 May 30.

Division of Rheumatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12(th) Avenue North, Sherbrooke, PQ, Canada. Electronic address:

MicroRNA (miRs) are small, non-coding RNA that post-transcriptionally regulate DNA expression. We hypothesized that specific miR profiles may be a feature of overactive osteoclasts in Paget's disease of bone (PDB), a disorder characterized by an increased and disorganized bone remodeling that typically begins with excessive bone resorption. We compared the expression profile of 13 miRs in human osteoclasts differentiated in vitro from peripheral blood mononuclear cells (PBMCs) of patients with PDB (n = 10) or age- and sex- matched healthy subjects (n = 10). Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165852DOI Listing

Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model.

Biochim Biophys Acta Mol Basis Dis 2020 May 30:165849. Epub 2020 May 30.

Rocky Mountain Regional VA Medical Center, USA; Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

Alzheimer's disease (AD) often coexists with other aging-associated diseases including obesity, diabetes, hypertension, and cardiovascular diseases. The early stage of these comorbidities is known as metabolic syndrome (MetS) which is highly prevalent in mid-life. An important cause of MetS is the deficiency of SIRT3, a mitochondrial deacetylase which enhances the functions of critical mitochondrial proteins, including metabolic enzymes, by deacetylation. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165849DOI Listing

Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.

Biochim Biophys Acta Mol Basis Dis 2020 May 29:165844. Epub 2020 May 29.

Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan; Centre for Cancer Cell Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, Australia. Electronic address:

The iron-containing protein, acireductone dioxygenase 1 (ADI1), is a dioxygenase important for polyamine synthesis and proliferation. Using differential proteomics, the studies herein demonstrated that ADI1 was significantly down-regulated by cellular iron depletion. This is important, since ADI1 contains a non-heme, iron-binding site critical for its activity. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165844DOI Listing

Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1.

Biochim Biophys Acta Mol Basis Dis 2020 May 29:165851. Epub 2020 May 29.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan. Electronic address:

ERK and Akt have been shown to regulate cell sensitivity to death-inducing stress by phosphorylating GSK-3β, a major modulator of the threshold for mitochondrial permeability transition. Here we examined intra-mitochondrial localization of the pro-survival kinases and their regulation by phosphatases. Stepwise trypsin digestion of mitochondria isolated from HEK293 or H9c2 cells was performed, and immunoblotting revealed that GSK-3β and ERK localized dominantly in the outer membrane (OM), while Akt resided at comparable levels in OM, the inner membrane (IM) and the matrix. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165851DOI Listing

Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway.

Biochim Biophys Acta Mol Basis Dis 2020 May 28:165848. Epub 2020 May 28.

Department of Anesthesiology, Xi'an Children's Hospital, Xi'an 710003, China. Electronic address:

Cardiac hypertrophy, including hypertension and valvular dysfunction, is a pathological feature of many cardiac diseases that ultimately leads to heart failure. Melatonin confers a protective role against pathological cardiac hypertrophy, but the underlying mechanisms remain elusive. In the present study, we hypothesized that melatonin protects against pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165848DOI Listing

A systematic review of genes affecting mitochondrial processes in cancer.

Biochim Biophys Acta Mol Basis Dis 2020 May 27:165846. Epub 2020 May 27.

Tecnologico de Monterrey, Escuela de Medicina, Cátedra de Bioinformática, Av. Morones Prieto No. 3000, Colonia Los Doctores, Monterrey, Nuevo León 64710, Mexico. Electronic address:

Malignant conversion of cancer cells requires efficient mitochondria reprogramming orchestrated by hundreds of genes. The transformation includes increased energy demand, biosynthesis of precursors, and reactive oxygen species needed to accelerate cell growth, proliferation, and survival. The reprogramming involves complex gene alterations that have not been methodically curated. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165846DOI Listing

Mitochondrial function in immune cells in health and disease.

Authors:
M M Faas P de Vos

Biochim Biophys Acta Mol Basis Dis 2020 May 27:165845. Epub 2020 May 27.

Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen and University Medical Centre Groningen, Groningen, the Netherlands.

One of the main functions of mitochondria is production of ATP for cellular energy needs, however, it becomes more recognized that mitochondria are involved in differentiation and activation processes of immune cells. Upon activation, immune cells have a high need for energy. Immune cells have different strategies to generate this energy. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165845DOI Listing

Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer.

Biochim Biophys Acta Mol Basis Dis 2020 May 27:165847. Epub 2020 May 27.

Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address:

Liquid biopsy refers to the sampling, screening, and detecting potential biomarkers in unique liquid samples for clinical use. Lung cancer is one of the most highly frequent cancer subtypes, which is hard to be early diagnosed and monitored by radiological and histopathological evaluation that are the most general and accurate methods. Circulating miRNA is a potential clinical examination index for tumor detection and monitoring tumorigenesis progression using liquid biopsy. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165847DOI Listing

Copper mediates mitochondrial biogenesis in retinal pigment epithelial cells.

Biochim Biophys Acta Mol Basis Dis 2020 May 23:165843. Epub 2020 May 23.

R S Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO, Vision Research Foundation, Sankara Nethralaya, College Road, Nungambakkam, Chennai - 6, India. Electronic address:

Age related macular degeneration (AMD) is a multifactorial disease with genetic, biochemical and environmental risk factors. We observed a significant increase in copper levels in choroid-RPE from donor eyeballs with AMD. Adult retinal pigment epithelial cells (ARPE19 cells) exposed to copper in-vitro showed a 2-fold increase in copper influx transporter CTR1 and copper uptake at 50 μM concentration. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165843DOI Listing

Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models.

Biochim Biophys Acta Mol Basis Dis 2020 May 21;1866(10):165842. Epub 2020 May 21.

Institute of Translational Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China; Department of Infectious Disease, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China. Electronic address:

Wilson's disease is an autosomal recessive disease characterized by excess copper accumulated in the liver and brain. It is caused by mutations in the copper transporter gene ATP7B. However, based on the poor understanding of the transcriptional program involved in the pathogenesis of Wilson's disease and the lack of more safe and efficient therapies, the identification of novel pathways and the establishment of complementary model systems of Wilson's disease are urgently needed. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165842DOI Listing

Ubiquitin ligases and medulloblastoma: genetic markers of the four consensus subgroups identified through transcriptome datasets.

Biochim Biophys Acta Mol Basis Dis 2020 May 20;1866(10):165839. Epub 2020 May 20.

Department of Biochemistry and Medical Genetics and Regenerative Medicine Program, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.

The ubiquitin proteasome system regulates key cellular processes in normal and in cancer cells. Herein, we review published data on the role of ubiquitin ligases in the four major subgroups of medulloblastoma (MB). While conventional literature serves as an initial source of information on cellular pathways in MB, large publicly available datasets of gene expression can be used to add information not previously identified in the literature. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165839DOI Listing

Cathelicidin represents a new target for manipulation of skin inflammation in Netherton syndrome.

Biochim Biophys Acta Mol Basis Dis 2020 May 19:165831. Epub 2020 May 19.

Department of Pharmacy, School of Health Sciences, University of Patras, Rion, Patras 26504, Greece. Electronic address:

Netherton syndrome (NS) is a severe ichthyosis caused by inactivating mutations in the SPINK5 gene encoding the serine protease inhibitor LEKTI. Spink5 mice recapitulate NS and die perinatally from extensive dehydration as a result of a severe defect of the epidermal barrier. We showed that deletion of Klk5 in Spink5 rescues neonatal lethality (Furio et al. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165831DOI Listing

Reprogramming of serine, glycine and one-carbon metabolism in cancer.

Biochim Biophys Acta Mol Basis Dis 2020 May 19;1866(10):165841. Epub 2020 May 19.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA; Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Metabolic pathways leading to the synthesis, uptake, and usage of the nonessential amino acid serine are frequently amplified in cancer. Serine encounters diverse fates in cancer cells, including being charged onto tRNAs for protein synthesis, providing head groups for sphingolipid and phospholipid synthesis, and serving as a precursor for cellular glycine and one-carbon units, which are necessary for nucleotide synthesis and methionine cycle reloading. This review will focus on the participation of serine and glycine in the mitochondrial one-carbon (SGOC) pathway during cancer progression, with an emphasis on the genetic and epigenetic determinants that drive SGOC gene expression. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165841DOI Listing

The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective.

Biochim Biophys Acta Mol Basis Dis 2020 May 11;1866(10):165834. Epub 2020 May 11.

Laboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Str., 02-093 Warsaw, Poland. Electronic address:

Mitochondria-associated membranes (MAM), physical platforms that enable communication between mitochondria and the endoplasmic reticulum (ER), are enriched with many proteins and enzymes involved in several crucial cellular processes, such as calcium (Ca) homeostasis, lipid synthesis and trafficking, autophagy and reactive oxygen species (ROS) production. Accumulating studies indicate that tumor suppressors and oncogenes are present at these intimate contacts between mitochondria and the ER, where they influence Ca flux between mitochondria and the ER or affect lipid homeostasis at MAM, consequently impacting cell metabolism and cell fate. Understanding these fundamental roles of mitochondria-ER contact sites as important domains for tumor suppressors and oncogenes can support the search for new and more precise anticancer therapies. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165834DOI Listing

Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte.

Biochim Biophys Acta Mol Basis Dis 2020 May 8:165832. Epub 2020 May 8.

Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada; Dalhousie Medicine New Brunswick, E2L 4L5 Saint John, NB, Canada. Electronic address:

Glucolipotoxicity following nutrient-overload causes cardiomyocyte injury by inhibiting TFEB and suppressing lysosomal function. We ascertained if besides the amount, do the type of fatty acid (FA) and duration of FA exposure regulate TFEB action and dictate cardiomyocyte viability. Saturated FA, palmitate, but not polyunsaturated FAs decreased TFEB content in a concentration- and time-dependent manner in cardiomyocytes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165832DOI Listing

Mitochondrial dysfunction in metabolic syndrome.

Authors:
Pankaj Prasun

Biochim Biophys Acta Mol Basis Dis 2020 May 16;1866(10):165838. Epub 2020 May 16.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address:

Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It is a global health problem. An estimated 20%-30% of adults of the world have metabolic syndrome. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165838DOI Listing

Sexes on the brain: Sex as multiple biological variables in the neuronal control of feeding.

Biochim Biophys Acta Mol Basis Dis 2020 May 16;1866(10):165840. Epub 2020 May 16.

Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, United States of America; Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA, United States of America. Electronic address:

Neuronal interactions at the level of vagal, homeostatic, and hedonic circuitry work to regulate the neuronal control of feeding. This integrative system appears to vary across sex and gender in the animal and human worlds. Most feeding research investigating these variations across sex and gender focus on how the organizational and activational mechanisms of hormones contribute to these differences. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165840DOI Listing

Signal pathway analysis of selected obesity-associated melanocortin-4 receptor class V mutants.

Biochim Biophys Acta Mol Basis Dis 2020 May 8;1866(8):165835. Epub 2020 May 8.

Department of Biochemistry & Molecular Biology, Libin Cardiovascular Institute and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada. Electronic address:

Mutations in the melanocortin-4 receptor (MC4R) in humans are the single most common cause of rare monogenic 1severe obesity, and polymorphisms in this gene are also associated with obesity in the general population. The MC4R is a G-protein coupled receptor, and in vitro analysis suggests that MC4R can signal through several different G-protein subtypes. In vivo studies show complex outcomes, with different G-proteins in different cells responsible for different physiological responses linked to obesity. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165835DOI Listing
May 2020
4.882 Impact Factor

Acetylation in cardiovascular diseases: Molecular mechanisms and clinical implications.

Biochim Biophys Acta Mol Basis Dis 2020 May 12;1866(10):165836. Epub 2020 May 12.

Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 210032, China. Electronic address:

Acetylation belongs to a class of post-translational modification (PTM) processes that epigenetically regulate gene expression and gene transcriptional activity. Reversible histone acetylation on lysine residues governs the interactions between DNA and histones to mediate chromatin remodeling and gene transcription. Non-histone protein acetylation complicates cellular function whereas acetylation of key mitochondrial enzymes regulates bioenergetic metabolism. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165836DOI Listing

Special edition: The NCLs/Batten disease.

Biochim Biophys Acta Mol Basis Dis 2020 May 5:165824. Epub 2020 May 5.

UCL MRC Laboratory for Molecular Cell Biology and UCL Great Ormond Street Institute of Child Health, University College London, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1016/j.bbadis.2020.165824DOI Listing

Targeting endothelial exosomes for the prevention of cardiovascular disease.

Biochim Biophys Acta Mol Basis Dis 2020 May 4;1866(8):165833. Epub 2020 May 4.

Diabetes and Cardiovascular Research Center, University of Missouri School of Medicine, Columbia, MO 65212, USA; Research Service, Harry S Truman Memorial Veterans Hospital, 800 Hospital Dr, Columbia, MO 65201, USA; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65212, USA. Electronic address:

Exosomes are small lipid bilayer-enclosed 30-140 nm diameter vesicles formed from endosomes. Exosomes are secreted by various cell types including endothelial cells, immune cells and other cardiovascular tissues, and they can be detected in plasma, urine, cerebrospinal fluid, as well as tissues. Exosomes were initially regarded as a disposal mechanism to discard unwanted materials from cells. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165833DOI Listing

Interplay between hormones and exercise on hippocampal plasticity across the lifespan.

Biochim Biophys Acta Mol Basis Dis 2020 May 3;1866(8):165821. Epub 2020 May 3.

Division of Medical Sciences and Neuroscience Graduate Program, University of Victoria, Victoria, BC, Canada; Island Medical Program, Faculty of Medicine, University of British Columbia, Victoria, BC, Canada. Electronic address:

The hippocampus is a brain structure known to play a central role in cognitive function (namely learning and memory) as well as mood regulation and affective behaviors due in part to its ability to undergo structural and functional changes in response to intrinsic and extrinsic stimuli. While structural changes are achieved through modulation of hippocampal neurogenesis as well as alterations in dendritic morphology and spine remodeling, functional (i.e. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165821DOI Listing

Analysis of gene expression profiles of lung cancer subtypes with machine learning algorithms.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 28;1866(8):165822. Epub 2020 Apr 28.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, China. Electronic address:

Lung cancer is one of the most common cancer types worldwide and causes more than one million deaths annually. Lung adenocarcinoma (AC) and lung squamous cell cancer (SCC) are two major lung cancer subtypes and have different characteristics in several aspects. Identifying their differentially expressed genes and different gene expression patterns can deepen our understanding of these two subtypes at the transcriptomic level. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165822DOI Listing

Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 28:165823. Epub 2020 Apr 28.

Laboratório de Bioenergética e Estresse Oxidativo, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

A wide array of molecular pathways has been investigated during the past decade in order to understand the mechanisms by which the practice of physical exercise promotes neuroprotection and reduces the risk of developing communicable and non-communicable chronic diseases. While a single session of physical exercise may induce a transient imbalance of cell homeostasis, repeated physical exercise sessions will improve immunosurveillance and immunocompetence. Additionally, immune cells from the central nervous system will acquire an anti-inflammatory phenotype, protecting central functions from age-induced cognitive decline. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188661PMC

Impact of high-intensity interval training and sprint interval training on peripheral markers of glycemic control in metabolic syndrome and type 2 diabetes.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 29;1866(8):165820. Epub 2020 Apr 29.

Department of Human Studies, University of Alabama at Birmingham, Birmingham, AL, United States of America.

Glycemic control is essential to reduce the risk of complications associated with metabolic syndrome (MetS) and type 2 diabetes (T2D). Aerobic and resistance exercise performed alone or in combination improve glycemic control in both conditions. However, perceived lack of time and commitment are considered principal barriers to performing exercise regularly. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165820DOI Listing

Corrigendum to "Differential response of liver sinusoidal endothelial cells and hepatocytes to oleic and palmitic acid revealed by Raman and CARS imaging." [Biochim. Biophys. Acta Mol. Basis Dis. 1866 (2020) 165763-72].

Biochim Biophys Acta Mol Basis Dis 2020 Apr 27:165804. Epub 2020 Apr 27.

Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, 30-348 Krakow, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2020.165804DOI Listing

Empagliflozin improves left ventricular diastolic function of db/db mice.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 28;1866(8):165807. Epub 2020 Apr 28.

Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany. Electronic address:

Objectives: Investigation of the effect of SGLT2 inhibition by empagliflozin on left ventricular function in a model of diabetic cardiomyopathy.

Background: SGLT2 inhibition is a new strategy to treat diabetes. In the EMPA-REG Outcome trial empagliflozin treatment reduced cardiovascular and overall mortality in patients with diabetes presumably due to beneficial cardiac effects, leading to reduced heart failure hospitalization. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165807DOI Listing

Mitochondrial transplantation ameliorates ischemia/reperfusion-induced kidney injury in rat.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 28;1866(8):165809. Epub 2020 Apr 28.

Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address:

No real therapeutic modality is currently available for Acute kidney injury (AKI) and if any, they are mainly supportive in nature. Therefore, developing a new therapeutic strategy is crucial. Mitochondrial dysfunction proved to be a key contributor to renal tubular cell death during AKI. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165809DOI Listing

Cardiolipin remodeling in Barth syndrome and other hereditary cardiomyopathies.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 27;1866(8):165803. Epub 2020 Apr 27.

Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, 97078 Würzburg, Germany. Electronic address:

Mitochondria play a prominent role in cardiac energy metabolism, and their function is critically dependent on the integrity of mitochondrial membranes. Disorders characterized by mitochondrial dysfunction are commonly associated with cardiac disease. The mitochondrial phospholipid cardiolipin directly interacts with a number of essential protein complexes in the mitochondrial membranes including the respiratory chain, mitochondrial metabolite carriers, and proteins critical for mitochondrial morphology. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165803DOI Listing

Modulation of mitochondria and NADPH oxidase function by the nitrate-nitrite-NO pathway in metabolic disease with focus on type 2 diabetes.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 25;1866(8):165811. Epub 2020 Apr 25.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Mitochondria play fundamental role in maintaining cellular metabolic homeostasis, and metabolic disorders including type 2 diabetes (T2D) have been associated with mitochondrial dysfunction. Pathophysiological mechanisms are coupled to increased production of reactive oxygen species and oxidative stress, together with reduced bioactivity/signaling of nitric oxide (NO). Novel strategies restoring these abnormalities may have therapeutic potential in order to prevent or even treat T2D and associated cardiovascular and renal co-morbidities. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165811DOI Listing

Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 24;1866(8):165805. Epub 2020 Apr 24.

Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA; Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84602, USA. Electronic address:

Ad libitum high-fat diet (HFD) induces obesity and skeletal muscle metabolic dysfunction. Liver kinase B1 (LKB1) regulates skeletal muscle metabolism by controlling the AMP-activated protein kinase family, but its importance in regulating muscle gene expression and glucose tolerance in obese mice has not been established. The purpose of this study was to determine how the lack of LKB1 in skeletal muscle (KO) affects gene expression and glucose tolerance in HFD-fed, obese mice. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165805DOI Listing

RHBDD2 overexpression promotes a chemoresistant and invasive phenotype to rectal cancer tumors via modulating UPR and focal adhesion genes.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 25;1866(8):165810. Epub 2020 Apr 25.

Centro de Investigaciones Inmunológicas Básicas y Aplicadas, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina. Electronic address:

The current standard of care for locally advanced rectal cancer (RC) is neoadjuvant radio-chemotherapy (NRC) with 5-fluorouracil (5Fu) as the main drug, followed by surgery and adjuvant chemotherapy. While a group of patients will achieve a pathological complete response, a significant percentage will not respond to the treatment. The Unfolding Protein Response (UPR) pathway is generally activated in tumors and results in resistance to radio-chemotherapy. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165810DOI Listing

Mitochondria-targeted drug delivery in cancers.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 22;1866(8):165808. Epub 2020 Apr 22.

Department of Pharmacy and BK21PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662, Republic of Korea. Electronic address:

Mitochondria are considered one of the most important subcellular organelles for targeting and delivering drugs because mitochondria are the main location for various cellular functions and energy (i.e., ATP) production, and mitochondrial dysfunctions and malfunctions cause diverse diseases such as neurodegenerative disorders, cardiovascular disorders, metabolic disorders, and cancers. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165808DOI Listing

Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 19;1866(8):165806. Epub 2020 Apr 19.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Diabetic cardiomyopathy (DCM) accounts for increasing deaths of diabetic patients, and effective therapeutic targets are urgently needed. Myocardial lipotoxicity, which is caused by cardiac non-oxidative metabolic fatty acids and cardiotoxic fatty acid metabolites accumulation, has gained more attention to explain the increasing prevalence of DCM. However, whether mammalian Ste20-like kinase 1 (Mst1) plays a role in lipotoxicity in type 2 diabetes-induced cardiomyopathy has not yet been illustrated. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165806DOI Listing

Differential expression of caveolin-1 during pathogenesis of combined pulmonary fibrosis and emphysema: Effect of phosphodiesterase-5 inhibitor.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 18;1866(8):165802. Epub 2020 Apr 18.

Department of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.

Introduction: Combined pulmonary fibrosis and emphysema (CPFE) is a relatively new entity within the spectrum of cigarette smoke induced lung disorders. Currently there is no consensus about its treatment. We hypothesized that caveolin-1 critically determines the parenchymal and vascular remodeling leading to the development of CPFE. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165802DOI Listing

Interplay between NADH oxidation by complex I, glutathione redox state and sirtuin-3, and its role in the development of insulin resistance.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 16;1866(8):165801. Epub 2020 Apr 16.

Facultad de Enfermería, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich 58260, México.

Metabolic diseases are characterized by high NADH/NAD ratios due to excessive electron supply, causing defective mitochondrial function and impaired sirtuin-3 (SIRT-3) activity, the latter driving to oxidative stress and altered fatty acid β-oxidation. NADH is oxidized by the complex I in the electron transport chain, thereby factors inhibiting complex I like acetylation, cardiolipin peroxidation, and glutathionylation by low GSH/GSSG ratios affects SIRT3 function by increasing the NADH/NAD ratio. In this review, we summarized the evidence supporting a role of the above events in the development of insulin resistance, which is relevant in the pathogenesis of obesity and diabetes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165801DOI Listing

Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic dysfunction promoted by a dysferlin mutation.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 16;1866(8):165800. Epub 2020 Apr 16.

Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago, Chile. Electronic address:

Dysferlinopathy is a genetic human disease caused by mutations in the gene that encodes the dysferlin protein (DYSF). Dysferlin is believed to play a relevant role in cell membrane repair. However, in dysferlin-deficient (blAJ) mice (a model of dysferlinopathies) the recovery of the membrane resealing function by means of the expression of a mini-dysferlin does not arrest progressive muscular damage, suggesting the participation of other unknown pathogenic mechanisms. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165800DOI Listing

Regulation of the cerebrovascular smooth muscle cell phenotype by mitochondrial oxidative injury and endoplasmic reticulum stress in simulated microgravity rats via the PERK-eIF2α-ATF4-CHOP pathway.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 15;1866(8):165799. Epub 2020 Apr 15.

Department of Cardiology & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China. Electronic address:

Microgravity exposure results in vascular remodeling and cardiovascular dysfunction. Here, the effects of mitochondrial oxidative stress on vascular smooth muscle cells (VSMCs) in rat cerebral arteries under microgravity simulated by hindlimb unweighting (HU) was studied. Endoplasmic reticulum (ER)-resident transmembrane sensor proteins and phenotypic markers of rat cerebral VSMCs were examined. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165799DOI Listing
April 2020
4.882 Impact Factor

Functional roles of GDF15 in modulating microenvironment to promote carcinogenesis.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 15;1866(8):165798. Epub 2020 Apr 15.

Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases research team (PEC2, EA 7460), University of Bourgogne - Franche-Comté, Faculty of Health Sciences, 7 boulevard Jeanne d'Arc, 21079 Dijon, France.

Obesity and related metabolic dysregulation are risk factors for many types of cancer. The interactions between a developing tumor and its microenvironment are known to implicate a complex "crosstalk" among the factors produced by the population of cells. Among these factors, Growth and differentiation factor 15 (GDF15) has a functional role in cancer. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165798DOI Listing

Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 14;1866(8):165797. Epub 2020 Apr 14.

Cellular and Molecular Neurobiology Area, Group of Neuroscience, SIU, Faculty of Medicine, University of Antioquia UdeA, Calle 70 No. 52 - 21, Medellín, Colombia. Electronic address:

Sporadic Alzheimer's disease (SAD) is the most common form of dementia, and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most frequent hereditary ischemic small vessel disease of the brain. Relevant biomarkers or specific metabolic signatures could provide powerful tools to manage these diseases. Therefore, the main goal of this study was to compare the postmortem frontal cortex gray matter, white matter and cerebrospinal fluid (CSF) between a cognitively healthy group and CADASIL and SAD groups. Read More

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The TGF-β profibrotic cascade targets ecto-5'-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 11;1866(7):165796. Epub 2020 Apr 11.

Institute of Biochemistry and Microbiology, Science Faculty, Universidad Austral de Chile, Valdivia, Chile. Electronic address:

Progressive diabetic nephropathy (DN) and loss of renal function correlate with kidney fibrosis. Crosstalk between TGF-β and adenosinergic signaling contributes to the phenotypic transition of cells and to renal fibrosis in DN models. We evaluated the role of TGF-β on NT5E gene expression coding for the ecto-5`-nucleotidase CD73, the limiting enzyme in extracellular adenosine production. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165796DOI Listing

Identification of proliferative diabetic retinopathy-associated genes on the protein-protein interaction network by using heat diffusion algorithm.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 8:165794. Epub 2020 Apr 8.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China; National Clinical Research Center for Eye Diseases, Shanghai 20080, China; Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai 20080, China. Electronic address:

Diabetic retinopathy is a common complication of diabetes mellitus that causes pathogenic damage to the retina. Particularly, the proliferative diabetic retinopathy (PDR) state can cause abnormal angiogenesis in the retina tissues and trigger the retina destruction in advanced stage. In the clinic, the symptoms during the initiation and progression of PDR are relatively unrecognizable. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165794DOI Listing
April 2020
4.882 Impact Factor

Retinoic acid receptor-beta prevents cisplatin-induced proximal tubular cell death.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 8;1866(7):165795. Epub 2020 Apr 8.

Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address:

Cisplatin's toxicity in renal tubular epithelial cells limits the therapeutic efficacy of this antineoplastic drug. In cultured human proximal tubular HK-2 cells (PTC) a prostaglandin uptake transporter (PGT)-dependent increase in intracellular prostaglandin E (iPGE) mediates cisplatin's toxicity (i.e. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165795DOI Listing

Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 8;1866(7):165793. Epub 2020 Apr 8.

Dept of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address:

Rett Syndrome (RTT) is a rare X-linked neurodevelopmental disorder which affects about 1: 10000 live births. In >95% of subjects RTT is caused by a mutation in Methyl-CpG binding protein-2 (MECP2) gene, which encodes for a transcription regulator with pleiotropic genetic/epigenetic activities. The molecular mechanisms underscoring the phenotypic alteration of RTT are largely unknown and this has impaired the development of therapeutic approaches to alleviate signs and symptoms during disease progression. Read More

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Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 4;1866(7):165792. Epub 2020 Apr 4.

Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital, Central South University, Changsha 410011, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, USA. Electronic address:

Renal ischemia-reperfusion is a major cause of acute kidney injury, a disease currently without effective treatments. Irisin was initially identified as an important factor produced by muscles to mediate the health benefits of exercise, and recent work has further suggested its protective effect against lung and liver injury. However, the role of Irisin in kidney diseases, including renal ischemia-reperfusion injury (IRI), remains unknown. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165792DOI Listing

Essential gene expression pattern of head and neck squamous cell carcinoma revealed by tumor-specific expression rule based on single-cell RNA sequencing.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 28;1866(7):165791. Epub 2020 Mar 28.

Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai 201210, China. Electronic address:

Head and neck squamous cell carcinoma (HNSCC) has been widely reported and considered as one of the most threatening diseases to human health. Derived from complicated tissue subtypes, HNSCC has diverse symptoms and pathogenesis. They make the identification of the core carcinogenic factors of such diseases at the multi-cell level difficult. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165791DOI Listing

Contribution of patient organisations to the NCLs.

Biochim Biophys Acta Mol Basis Dis 2020 Mar 26:165773. Epub 2020 Mar 26.

BDSRA, 2780 Airport Drive, Ste 342 Columbus, OH 43219.

This review will summarise the achievements of Patient Organisations and Foundations started by affected Batten disease families, with an emphasis on their recent contribution to Batten disease, examine the benefits and pitfalls of their interactions with scientists and propose a way forward. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165773DOI Listing

Dietary influence on central nervous system myelin production, injury, and regeneration.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 26;1866(7):165779. Epub 2020 Mar 26.

Department of Physical Medicine & Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN 55905, USA; Neuroscience Program, Mayo Clinic School of Biomedical Sciences, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

Oligodendrocytes not only produce myelin to facilitate nerve impulse conduction, but are also essential metabolic partners of the axon. Oligodendrocyte loss and myelin destruction, as occurs in multiple sclerosis (MS), leaves axons vulnerable to degeneration and permanent neurological deficits ensue. Many studies now propose that lifestyle factors such as diet may impact demyelinating conditions, including MS. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165779DOI Listing

Proteostasis regulators as potential rescuers of PMM2 activity.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 25;1866(7):165777. Epub 2020 Mar 25.

Centro de Diagnóstico de Enfermedades Moleculares, Centro de Biología Molecular-CSIC-UAM, Universidad Autónoma de Madrid, CIBERER, IdiPAZ, Spain. Electronic address:

Phosphomannomutase 2 deficiency (PMM2-CDG) is the most common N-glycosylation disorder. To date there is no treatment. Following the identification of a number of destabilizing pathogenic variants, our group suggested PMM2-CDG to be a conformational disease. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165777DOI Listing

Exercise, redox system and neurodegenerative diseases.

Biochim Biophys Acta Mol Basis Dis 2020 Mar 25:165778. Epub 2020 Mar 25.

Research Institute of Sport Science, University of Physical Education, Budapest, Hungary; Faculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan. Electronic address:

Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165778DOI Listing