280 results match your criteria Biochimica Et Biophysica Acta-bioenergetics[Journal]


Mechanism and impact of catecholamine conversion by Vibrio cholerae.

Biochim Biophys Acta Bioenerg 2019 Apr 12. Epub 2019 Apr 12.

Institute of Microbiology, University of Hohenheim, Stuttgart, Germany. Electronic address:

Bacterial pathogens are influenced by signaling molecules including the catecholamines adrenaline and noradrenaline which are host-derived hormones and neurotransmitters. Adrenaline and noradrenaline modulate growth, motility and virulence of bacteria. We show that adrenaline is converted by the pathogen Vibrio cholerae to adrenochrome in the course of respiration, and demonstrate that superoxide produced by the respiratory, Na - translocating NADH:quinone oxidoreductase (NQR) acts as electron acceptor in the oxidative conversion of adrenaline to adrenochrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00052728193003
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http://dx.doi.org/10.1016/j.bbabio.2019.04.003DOI Listing
April 2019
2 Reads

Fourier transform visible and infrared difference spectroscopy for the study of P700 in photosystem I from Fischerella thermalis PCC 7521 cells grown under white light and far-red light: Evidence that the A cofactor is chlorophyll f.

Biochim Biophys Acta Bioenerg 2019 Apr 13;1860(6):452-460. Epub 2019 Apr 13.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA; Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, USA.

(P700 - P700) Fourier transform visible and infrared difference spectra (DS) have been obtained using photosystem I (PSI) complexes isolated from cells of Fischerella thermalis PCC 7521 grown under white light (WL) or far-red light (FRL). PSI from cells grown under FRL (FRL-PSI) contain ~8 chlorophyll f (Chl f) molecules (Shen et al., Photosynth. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.04.002DOI Listing

Phospholipid distributions in purple phototrophic bacteria and LH1-RC core complexes.

Biochim Biophys Acta Bioenerg 2019 Apr 8. Epub 2019 Apr 8.

Faculty of Science, Ibaraki University, Mito 310-8512, Japan. Electronic address:

In contrast to plants, algae and cyanobacteria that contain glycolipids as the major lipid components in their photosynthetic membranes, phospholipids are the dominant lipids in the membranes of anoxygenic purple phototrophic bacteria. Although the phospholipid compositions in whole cells or membranes are known for a limited number of the purple bacteria, little is known about the phospholipids associated with individual photosynthetic complexes. In this study, we investigated the phospholipid distributions in both membranes and the light-harvesting 1-reaction center (LH1-RC) complexes purified from several purple sulfur and nonsulfur bacteria. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.04.001DOI Listing

Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase.

Biochim Biophys Acta Bioenerg 2019 May 22;1860(5):375-382. Epub 2019 Mar 22.

School of Tropical Medicine and Global Health, Nagasaki University, Sakamoto 1-12-4, Nagasaki 852-8523, Japan; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Hongo 7-3-1, Tokyo 113-0033, Japan; Department of Host-Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Sakamoto 1-12-4, Nagasaki 852-8523, Japan.

The alternative oxidase (AOX) is a monotopic diiron carboxylate protein which catalyzes the four-electron reduction of dioxygen to water by ubiquinol. Although we have recently determined the crystal structure of Trypanosoma brucei AOX (TAO) in the presence and absence of ascofuranone (AF) derivatives (which are potent mixed type inhibitors) the mechanism by which ubiquinol and dioxygen binds to TAO remain inconclusive. In this article, ferulenol was identified as the first competitive inhibitor of AOX which has been used to probe the binding of ubiquinol. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00052728193002
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http://dx.doi.org/10.1016/j.bbabio.2019.03.008DOI Listing
May 2019
8 Reads
5.353 Impact Factor

Proton leakage across lipid bilayers: Oxygen atoms of phospholipid ester linkers align water molecules into transmembrane water wires.

Biochim Biophys Acta Bioenerg 2019 Mar 20;1860(6):439-451. Epub 2019 Mar 20.

Department of Physics, Osnabrueck University, 49069 Osnabrueck, Germany; School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow 119991, Russia; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119991, Russia. Electronic address:

Up to half of the cellular energy gets lost owing to membrane proton leakage. The permeability of lipid bilayers to protons is by several orders of magnitude higher than to other cations, which implies efficient proton-specific passages. The nature of these passages remains obscure. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.03.001DOI Listing

The role of water-water cycle in regulating the redox state of photosystem I under fluctuating light.

Biochim Biophys Acta Bioenerg 2019 May 16;1860(5):383-390. Epub 2019 Mar 16.

Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650201, China. Electronic address:

The regulation of photosystem I (PSI) redox state under fluctuating light was investigated for four species using P700 measurement and electrochromic shift analysis. Species included the angiosperms Camellia japonica, Bletilla striata and Arabidopsis thaliana and the fern Cyrtomium fortunei. For the first seconds after transition from low to high light, all species showed relatively low levels of the proton gradient (ΔpH) across the thylakoid membranes. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.03.007DOI Listing

Glutamine regulates mitochondrial uncoupling protein 2 to promote glutaminolysis in neuroblastoma cells.

Biochim Biophys Acta Bioenerg 2019 May 15;1860(5):391-401. Epub 2019 Mar 15.

Institute of Physiology, Pathophysiology and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria. Electronic address:

Mitochondrial uncoupling protein 2 (UCP2) is highly abundant in rapidly proliferating cells that utilize aerobic glycolysis, such as stem cells, cancer cells, and cells of the immune system. However, the function of UCP2 has been a longstanding conundrum. Considering the strict regulation and unusually short life time of the protein, we propose that UCP2 acts as a "signaling protein" under nutrient shortage in cancer cells. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.03.006DOI Listing

Structural and spectroscopic characterization of HCP2.

Biochim Biophys Acta Bioenerg 2019 May 15;1860(5):414-424. Epub 2019 Mar 15.

MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA; Environmental Genomics and Systems Biology and Molecular Biophysics and Integrated Bioimaging Divisions, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA. Electronic address:

The Helical Carotenoid Proteins (HCPs) are a large group of newly identified carotenoid-binding proteins found in ecophysiologically diverse cyanobacteria. They likely evolved before becoming the effector (quenching) domain of the modular Orange Carotenoid Protein (OCP). The number of discrete HCP families-at least nine-suggests they are involved in multiple distinct functions. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.03.004DOI Listing
May 2019
1 Read

Enhanced NPQ affects long-term acclimation in the spring ephemeral Berteroa incana.

Biochim Biophys Acta Bioenerg 2019 Mar 15. Epub 2019 Mar 15.

School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom. Electronic address:

The spring ephemeral Berteroa incana is a familial relative of Arabidopsis thaliana and thrives in a diverse range of terrestrial ecosystems. Within this study, the novel chlorophyll fluorescence parameter of photochemical quenching in the dark (qPd) was used to measure the redox state of the primary quinone electron acceptor (Q) in order to estimate the openness of photosystem II (PSII) reaction centres (RC). From this, the early onset of photoinactivation can be sensitively quantified alongside the light tolerance of PSII and the photoprotective efficiency of nonphotochemical quenching (NPQ). Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.03.005DOI Listing
March 2019
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Contribution of NDH-dependent cyclic electron transport around photosystem I to the generation of proton motive force in the weak mutant allele of pgr5.

Biochim Biophys Acta Bioenerg 2019 May 13;1860(5):369-374. Epub 2019 Mar 13.

Department of Botany, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. Electronic address:

In angiosperms, cyclic electron transport (CET) around photosystem I (PSI) consists of two pathways, depending on PGR5/PGRL1 proteins and the chloroplast NDH complex. In single mutants defective in chloroplast NDH, photosynthetic electron transport is only slightly affected at low light intensity, but in double mutants impaired in both CET pathways photosynthesis and plant growth are severely affected. The question is whether this strong mutant phenotype observed in double mutants can be simply explained by the additive effect of defects in both CET pathways. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.03.003DOI Listing

The carboxyl-terminal helical domain of the ATP synthase γ subunit is involved in ε subunit conformation and energy coupling.

Biochim Biophys Acta Bioenerg 2019 May 12;1860(5):361-368. Epub 2019 Mar 12.

Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga 526-0829, Japan. Electronic address:

The γ subunit located at the center of ATP synthase (FF) plays critical roles in catalysis. Escherichia coli mutant with Pro substitution of the γ subunit residue γLeu218, which are located the rotor shaft near the c subunit ring, decreased NADH-driven ATP synthesis activity and ATP hydrolysis-dependent H transport of membranes to ~60% and ~40% of the wild type, respectively, without affecting FF assembly. Consistently, the mutant was defective in growth by oxidative phosphorylation, indicating that energy coupling is impaired by the mutation. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.03.002DOI Listing
May 2019
1 Read

The mechanism of cyclic electron flow.

Biochim Biophys Acta Bioenerg 2019 May 7;1860(5):433-438. Epub 2019 Mar 7.

Institut de Biologie Physico-Chimique, UMR 7141 CNRS-UPMC, 13 rue P. et M. Curie, 75005 Paris, France.

Apart from the canonical light-driven linear electron flow (LEF) from water to CO, numerous regulatory and alternative electron transfer pathways exist in chloroplasts. One of them is the cyclic electron flow around Photosystem I (CEF), contributing to photoprotection of both Photosystem I and II (PSI, PSII) and supplying extra ATP to fix atmospheric carbon. Nonetheless, CEF remains an enigma in the field of functional photosynthesis as we lack understanding of its pathway. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.12.005DOI Listing
May 2019
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The role of far-red spectral states in the energy regulation of phycobilisomes.

Biochim Biophys Acta Bioenerg 2019 Apr 2;1860(4):341-349. Epub 2019 Feb 2.

Department of Physics, University of Pretoria, Pretoria 0023, South Africa; Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, the Netherlands.

The main light-harvesting pigment-protein complex of cyanobacteria and certain algae is the phycobilisome, which harvests sunlight and regulates the flow of absorbed energy to provide the photochemical reaction centres with a constant energy throughput. At least two light-driven mechanisms of excited energy quenching in phycobilisomes have been identified: the dominant mechanism in many strains of cyanobacteria depends on the orange carotenoid protein (OCP), while the second mechanism is intrinsically available to a phycobilisome and is possibly activated faster than the former. Recent single molecule spectroscopy studies have shown that far-red (FR) emission states are related to the OCP-dependent mechanism and it was proposed that the second mechanism may involve similar states. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00052728183062
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http://dx.doi.org/10.1016/j.bbabio.2019.01.007DOI Listing
April 2019
7 Reads

A highly efficient heptamethine cyanine antenna for photosynthetic Reaction Center: From chemical design to ultrafast energy transfer investigation of the hybrid system.

Biochim Biophys Acta Bioenerg 2019 Apr 2;1860(4):350-359. Epub 2019 Feb 2.

Dipartimento di Chimica, Università degli Studi di Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy. Electronic address:

The photosynthetic Reaction Center (RC) from the purple bacterium Rhodobacter sphaeroides has unique photoconversion capabilities, that can be exploited in assembly biohybrid devices for applications in solar energy conversion. Extending the absorption cross section of isolated RC through covalent functionalization with ad-hoc synthesized artificial antennas is a successful strategy to outperform the efficiency of the pristine photoenzyme under visible light excitation. Here we report a new heptamethine cyanine antenna that, upon covalent binding to RC, forms a biohybrid (hCyN7-RC) which, under white light excitation, has doubled photoconversion efficiency versus the bare photoenzyme. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.01.009DOI Listing
April 2019
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Maximal cyclic electron flow rate is independent of PGRL1 in Chlamydomonas.

Biochim Biophys Acta Bioenerg 2019 May 1;1860(5):425-432. Epub 2019 Feb 1.

Institut de Biologie Physico-Chimique, UMR 7141 CNRS-Sorbonne Université, 13 rue P. et M. Curie, 75005 Paris, France.

Cyclic electron flow (CEF) is defined as a return of the reductants from the acceptor side of Photosystem I (PSI) to the pool of its donors via the cytochrome bf. It is described to be complementary to the linear electron flow and essential for photosynthesis. However, despite many efforts aimed to characterize CEF, its pathway and its regulation modes remain equivocal, and its physiological significance is still not clear. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.01.004DOI Listing

Mechanism of action of an old antibiotic revisited: Role of calcium ions in protonophoric activity of usnic acid.

Biochim Biophys Acta Bioenerg 2019 Apr 30;1860(4):310-316. Epub 2019 Jan 30.

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.

Usnic acid (UA), an old antibiotic and one of the first described mitochondrial uncouplers, has demonstrated many beneficial activities, such as antimicrobial, antiviral, antitumour and anti-inflammatory properties. Here, we performed a thorough investigation of effects of usnic acid and its analogues on artificial planar bilayer lipid membrane (BLM), rat liver mitochondria and bacteria. Surprisingly enough, all of the three hydroxyl groups of UA appeared to be involved in its proton-shuttling activity on BLM. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.01.005DOI Listing

Tuning the redox properties of a [4Fe-4S] center to modulate the activity of Mo-bisPGD periplasmic nitrate reductase.

Biochim Biophys Acta Bioenerg 2019 May 29;1860(5):402-413. Epub 2019 Jan 29.

Aix Marseille Univ, CNRS, BIP Laboratoire de Bioénergétique et Ingénierie des Protéines, Marseille, France. Electronic address:

Molybdoenzymes are ubiquitous in living organisms and catalyze, for most of them, oxidation-reduction reactions using a large range of substrates. Periplasmic nitrate reductase (NapAB) from Rhodobacter sphaeroides catalyzes the 2-electron reduction of nitrate into nitrite. Its active site is a Mo bis-(pyranopterin guanine dinucleotide), or Mo-bisPGD, found in most prokaryotic molybdoenzymes. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.01.003DOI Listing
May 2019
2 Reads

Chemical rescue of H delivery in proton transfer mutants of reaction center of photosynthetic bacteria.

Authors:
Péter Maróti

Biochim Biophys Acta Bioenerg 2019 Apr 29;1860(4):317-324. Epub 2019 Jan 29.

Institute of Medical Physics, University of Szeged, Hungary. Electronic address:

In the native and most mutant reaction centers of bacterial photosynthesis, the electron transfer is coupled to proton transfer and is rate limiting for the second reduction of Q → QH. In the presence of divalent metal ions (e.g. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.01.006DOI Listing

New insights on Chl function in Photosystem II from site-directed mutants of D1/T179 in Thermosynechococcus elongatus.

Biochim Biophys Acta Bioenerg 2019 Apr 29;1860(4):297-309. Epub 2019 Jan 29.

Graduate School of Science and Technology, Ehime University, Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan; Proteo-Science Research Center, Ehime University, Bunkyo-cho, Matsuyama, Ehime 790-8577, Japan. Electronic address:

The monomeric chlorophyll, Chl, which is located between the PP chlorophyll pair and the pheophytin, Pheo is the longest wavelength chlorophyll in the heart of Photosystem II and is thought to be the primary electron donor. Its central Mg is liganded to a water molecule that is H-bonded to D1/T179. Here, two site-directed mutants, D1/T179H and D1/T179V, were made in the thermophilic cyanobacterium, Thermosynechococcus elongatus, and characterized by a range of biophysical techniques. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.01.008DOI Listing
April 2019
2 Reads

Computational analyses, molecular dynamics, and mutagenesis studies of unprocessed form of [NiFe] hydrogenase reveal the role of disorder for efficient enzyme maturation.

Biochim Biophys Acta Bioenerg 2019 Apr 29;1860(4):325-340. Epub 2019 Jan 29.

Centro de Biotecnología y Genómica de Plantas (C.B.G.P.) UPM-INIA, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain; Departamento de Biotecnología-Biología Vegetal, Escuela Técnica Superior de Ingeniería Agronómica, Alimentaria y de Biosistemas, Universidad Politécnica de Madrid, Madrid, Spain. Electronic address:

Biological production and oxidation of hydrogen is mediated by hydrogenases, key enzymes for these energy-relevant reactions. Synthesis of [NiFe] hydrogenases involves a complex series of biochemical reactions to assemble protein subunits and metallic cofactors required for enzyme function. A final step in this biosynthetic pathway is the processing of a C-terminal tail (CTT) from its large subunit, thus allowing proper insertion of nickel in the unique NiFe(CN)CO cofactor present in these enzymes. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.01.001DOI Listing

Mapping the excitation energy migration pathways in phycobilisomes from the cyanobacterium Acaryochloris marina.

Biochim Biophys Acta Bioenerg 2019 Apr 28;1860(4):286-296. Epub 2019 Jan 28.

Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 32000, Israel.

In this study, we use ultrafast time-resolved absorption and fluorescence spectroscopies to examine A. marina phycobilisomes isolated from cells grown under light of different intensities and spectral regimes. Investigations were performed at room temperature and at 77 K. Read More

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http://dx.doi.org/10.1016/j.bbabio.2019.01.002DOI Listing

Two-dimensional spectroscopy for non-specialists.

Biochim Biophys Acta Bioenerg 2019 Apr 21;1860(4):271-285. Epub 2018 Dec 21.

Institute of Chemical Physics, Faculty of Physics, Vilnius University, Sauletekio 9-III, Vilnius 10222, Lithuania; Department of Molecular Compound Physics, Center for Physical Sciences and Technology, Sauletekio 3, Vilnius 10257, Lithuania. Electronic address:

Detailed studies of the excitation dynamics in photosynthetic pigment-proteins require an application of a wide range of spectroscopic methods. From the later part of the previous century, pump-probe and time-resolved fluorescence spectroscopy provided an impressive amount of information. Being simple to grasp, these methods are well-understood and widely used by the photosynthesis research community. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00052728183024
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http://dx.doi.org/10.1016/j.bbabio.2018.12.006DOI Listing
April 2019
13 Reads

The cytochrome b lysine 329 residue is critical for ubihydroquinone oxidation and proton release at the Q site of bacterial cytochrome bc.

Biochim Biophys Acta Bioenerg 2019 Feb 12;1860(2):167-179. Epub 2018 Dec 12.

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

The ubihydroquinone:cytochrome (cyt) c oxidoreductase (or cyt bc) is an important enzyme for photosynthesis and respiration. In bacteria like Rhodobacter capsulatus, this membrane complex has three subunits, the iron‑sulfur protein (ISP) with its FeS cluster, cyt c and cyt b, forming two catalytic domains, the Q (hydroquinone (QH) oxidation) and Q (quinone (Q) reduction) sites. At the Q site, the electron transfer pathways originating from QH oxidation are known, but their associated proton release routes are less well defined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00052728183019
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http://dx.doi.org/10.1016/j.bbabio.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317905PMC
February 2019
11 Reads

Efficiency of excitation energy trapping in the green photosynthetic bacterium Chlorobaculum tepidum.

Biochim Biophys Acta Bioenerg 2019 Feb 8;1860(2):147-154. Epub 2018 Dec 8.

Laboratory of Biophysics, Wageningen University, Wageningen, the Netherlands; MicroSpectroscopy Research Facility, Wageningen University, Wageningen, the Netherlands. Electronic address:

During the millions of years of evolution, photosynthetic organisms have adapted to almost all terrestrial and aquatic habitats, although some environments are obviously more suitable for photosynthesis than others. Photosynthetic organisms living in low-light conditions require on the one hand a large light-harvesting apparatus to absorb as many photons as possible. On the other hand, the excitation trapping time scales with the size of the light-harvesting system, and the longer the distance over which the formed excitations have to be transferred, the larger the probability to lose excitations. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.12.004DOI Listing
February 2019
1 Read

Photochemical study of a cyanobacterial chloride-ion pumping rhodopsin.

Biochim Biophys Acta Bioenerg 2019 Feb 7;1860(2):136-146. Epub 2018 Dec 7.

Faculty of Advanced Life Science, Hokkaido University, Sapporo 060-0810, Japan; Global Station for Soft Matter, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo 060-0810, Japan.

Mastigocladopsis repens halorhodopsin (MrHR) is a Cl-pumping rhodopsin that belongs to a distinct cluster far from other Cl pumps. We investigated its pumping function by analyzing its photocycle and the effect of amino acid replacements. MrHR can bind I similar to Cl but cannot transport it. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.12.001DOI Listing
February 2019
16 Reads

Residue 249 in subunit beta regulates ADP inhibition and its phosphate modulation in Escherichia coli ATP synthase.

Biochim Biophys Acta Bioenerg 2019 Mar 7;1860(3):181-188. Epub 2018 Dec 7.

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia. Electronic address:

ATPase activity of proton-translocating FF-ATP synthase (F-type ATPase or F-ATPase) is suppressed in the absence of protonmotive force by several regulatory mechanisms. The most conservative of these mechanisms found in all enzymes studied so far is allosteric inhibition of ATP hydrolysis by MgADP (ADP-inhibition). When MgADP is bound without phosphate in the catalytic site, the enzyme lapses into an inactive state with MgADP trapped. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00052728183064
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http://dx.doi.org/10.1016/j.bbabio.2018.12.003DOI Listing
March 2019
22 Reads

Corrigendum to "probing the role of valine 185 of the D1 protein in the photosystem II oxygen evolution" [Biochim. Biophys. Acta Bioenerg. 1859 (2018) 1259-1273].

Biochim Biophys Acta Bioenerg 2019 Mar 6;1860(3):270. Epub 2018 Dec 6.

I(2)BC, UMR CNRS 9198, CEA Saclay, 91191 Gif-sur-Yvette, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2018.11.019DOI Listing

Elimination of proton donor strongly affects directionality and efficiency of proton transport in ESR, a light-driven proton pump from Exiguobacterium sibiricum.

Biochim Biophys Acta Bioenerg 2019 Jan 18;1860(1):1-11. Epub 2018 Sep 18.

Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Ul. Miklukho-Maklaya, 16/10, Russian Federation. Electronic address:

ESR from Exiguobacterium sibiricum is a retinal protein which functions as a proton pump. Unusual feature of ESR is that a lysine residue is present at a site for the internal proton donor, which in other proton pumps is a carboxylic residue. Replacement of Lys96 with alanine slows reprotonation of the Schiff base by two orders of magnitude, indicating that Lys96 and interacting water molecules function as internal proton donor to the Schiff base. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.09.365DOI Listing
January 2019
2 Reads

Radioprotective role of cyanobacterial phycobilisomes.

Biochim Biophys Acta Bioenerg 2019 Feb 20;1860(2):121-128. Epub 2018 Nov 20.

Department of Biophysics, Faculty of Biology, M.V. Lomonosov Moscow State University, 119992 Moscow, Russia.

Cyanobacteria are thought to be responsible for pioneering dioxygen production and the so-called "Great Oxygenation Event" that determined the formation of the ozone layer and the ionosphere restricting ionizing radiation levels reaching our planet, which increased biological diversity but also abolished the necessity of radioprotection. We speculated that ancient protection mechanisms could still be present in cyanobacteria and studied the effect of ionizing radiation and space flight during the Foton-M4 mission on Synechocystis sp. PCC6803. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.018DOI Listing
February 2019
13 Reads

Fasting promotes functional changes in liver mitochondria.

Biochim Biophys Acta Bioenerg 2019 Feb 20;1860(2):129-135. Epub 2018 Nov 20.

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:

Overnight fasting of rodents is commonly adopted in protocols to obtain isolated liver mitochondria, but the effects of fasting itself on mitochondrial function are poorly characterized. In this study we show that overnight fasting (15 h) promotes a shift in the liver mitochondrial bioenergetic profile, with a reduction in ADP-stimulated and maximal respiration, lower membrane potentials and lower resistance to Ca-induced mitochondrial permeability transition. Short term fasting (4 h) promoted similar changes, suggesting that this is a physiological shift in mitochondrial function associated with fasting, but not torpor. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.017DOI Listing
February 2019
14 Reads

A new mechanistic model for an O-protected electron-bifurcating hydrogenase, Hnd from Desulfovibrio fructosovorans.

Biochim Biophys Acta Bioenerg 2018 Dec 18;1859(12):1302-1312. Epub 2018 Sep 18.

Aix Marseille Univ, CNRS, BIP, 31 Chemin Joseph Aiguier, 13402, Marseille Cedex 09, France. Electronic address:

The genome of the sulfate-reducing and anaerobic bacterium Desulfovibrio fructosovorans encodes different hydrogenases. Among them is Hnd, a tetrameric cytoplasmic [FeFe] hydrogenase that has previously been described as an NADP-specific enzyme (Malki et al., 1995). Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.09.364DOI Listing
December 2018
13 Reads
5.353 Impact Factor

Critical evaluation of electron transfer kinetics in P-F/F, P-F, and P-A Photosystem I core complexes in liquid and in trehalose glass.

Biochim Biophys Acta Bioenerg 2018 Dec 19;1859(12):1288-1301. Epub 2018 Sep 19.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA; Department of Chemistry, The Pennsylvania State University, University Park, PA, USA. Electronic address:

This work aims to fully elucidate the effects of a trehalose glassy matrix on electron transfer reactions in cyanobacterial Photosystem I (PS I). Forward and backward electron transfer rates from A and A to F and charge recombination rates from A, A, A, F, and [F/F] to P were measured in P-F/F complexes, P-F cores, and P-A cores, both in liquid and in a trehalose glassy matrix at 11% humidity. By comparing CONTIN-resolved kinetic events over 6 orders of time in increasingly simplified versions of PS I at 480 nm, a wavelength that reports primarily A/A oxidation, and over 9 orders of time at 830 nm, a wavelength that reports P reduction and A oxidation, assignments could be made for nearly all of the resolved kinetic phases. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.09.367DOI Listing
December 2018
15 Reads

Molecular dynamics and structural models of the cyanobacterial NDH-1 complex.

Biochim Biophys Acta Bioenerg 2019 Mar 16;1860(3):201-208. Epub 2018 Nov 16.

Department of Chemistry, Technical University of Munich (TUM), Lichtenbergstraße 4, Garching D-85747, Germany. Electronic address:

NDH-1 is a gigantic redox-driven proton pump linked with respiration and cyclic electron flow in cyanobacterial cells. Based on experimentally resolved X-ray and cryo-EM structures of the respiratory complex I, we derive here molecular models of two isoforms of the cyanobacterial NDH-1 complex involved in redox-driven proton pumping (NDH-1L) and CO-fixation (NDH-1MS). Our models show distinct structural and dynamic similarities to the core architecture of the bacterial and mammalian respiratory complex I. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358722PMC
March 2019
11 Reads

Cation-dependent changes in the thylakoid membrane appression of the diatom Thalassiosira pseudonana.

Biochim Biophys Acta Bioenerg 2019 Jan 15;1860(1):41-51. Epub 2018 Nov 15.

Institute of Molecular Biosciences, Goethe University Frankfurt, Max-von-Laue Straße 9, 60438 Frankfurt, Germany. Electronic address:

Diatoms show a special organisation of their plastid membranes, such that their thylakoids span the entire plastid in bands of three. While in higher plants the interaction of the light harvesting complex II and photosystem II with divalent cations (especially Mg) was found to take part in the interplay of electrostatic attraction and repulsion in grana membrane appression, for diatoms the key players in maintaining proper membrane distances were not identified so far. In this work, we investigated the changes in the thylakoid architecture of Thalassiosira pseudonana in reaction to different salts by using circular dichroism and fluorescence spectroscopy in combination with other techniques. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.003DOI Listing
January 2019
12 Reads

Redox-state dependent blinking of single photosystem I trimers at around liquid-nitrogen temperature.

Biochim Biophys Acta Bioenerg 2019 Jan 11;1860(1):30-40. Epub 2018 Nov 11.

Department of Chemistry, Graduate School of Science, Tohoku University, Aramaki Aza Aoba, Aoba-ku, Sendai 980-8578, Japan. Electronic address:

Efficient light harvesting in a photosynthetic antenna system is disturbed by a ragged and fluctuating energy landscape of the antenna pigments in response to the conformation dynamics of the protein. This situation is especially pronounced in Photosystem I (PSI) containing red shifted chlorophylls (red Chls) with the excitation energy much lower than the primary donor. The present study was conducted to clarify light-harvesting dynamics of PSI isolated from Synechocystis sp. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.002DOI Listing
January 2019

Molecular mechanism of metabolic NAD(P)H-dependent electron-transfer systems: The role of redox cofactors.

Authors:
Takashi Iyanagi

Biochim Biophys Acta Bioenerg 2019 Mar 9;1860(3):233-258. Epub 2018 Nov 9.

Department of Life Science, Graduate School of Life Science, University of Hyogo, Koto 3-2-1, Kamighori, Ako, Hyogo 678-1297, Japan.

NAD(P)H-dependent electron-transfer (ET) systems require three functional components: a flavin-containing NAD(P)H-dehydrogenase, one-electron carrier and metal-containing redox center. In principle, these ET systems consist of one-, two- and three-components, and the electron flux from pyridine nucleotide cofactors, NADPH or NADH to final electron acceptor follows a linear pathway: NAD(P)H → flavin → one-electron carrier → metal containing redox center. In each step ET is primarily controlled by one- and two-electron midpoint reduction potentials of protein-bound redox cofactors in which the redox-linked conformational changes during the catalytic cycle are required for the domain-domain interactions. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.014DOI Listing
March 2019
11 Reads

Regulated chloroplast transcription termination.

Biochim Biophys Acta Bioenerg 2019 Jan 8;1860(1):69-77. Epub 2018 Nov 8.

Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China. Electronic address:

Transcription termination by the RNA polymerase (RNAP) is a fundamental step of gene expression that involves the release of the nascent transcript and dissociation of the RNAP from the DNA template. However, the functional importance of termination extends beyond the mere definition of the gene borders. Chloroplasts originate from cyanobacteria and possess their own gene expression system. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.011DOI Listing
January 2019
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Engineering of B800 bacteriochlorophyll binding site specificity in the Rhodobacter sphaeroides LH2 antenna.

Biochim Biophys Acta Bioenerg 2019 Mar 9;1860(3):209-223. Epub 2018 Nov 9.

Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK. Electronic address:

The light-harvesting 2 complex (LH2) of the purple phototrophic bacterium Rhodobacter sphaeroides is a highly efficient, light-harvesting antenna that allows growth under a wide-range of light intensities. In order to expand the spectral range of this antenna complex, we first used a series of competition assays to measure the capacity of the non-native pigments 3-acetyl chlorophyll (Chl) a, Chl d, Chl f or bacteriochlorophyll (BChl) b to replace native BChl a in the B800 binding site of LH2. We then adjusted the B800 site and systematically assessed the binding of non-native pigments. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358721PMC
March 2019
9 Reads

Measuring the functionality of the mitochondrial pumping complexes with multi-wavelength spectroscopy.

Biochim Biophys Acta Bioenerg 2019 Jan 8;1860(1):89-101. Epub 2018 Nov 8.

Cardiovascular Division, King's College London, British Heart Foundation Centre of Excellence, 125 Coldharbour Lane, London SE5 9NU, United Kingdom. Electronic address:

The proton pumps of the mitochondrial electron transport chain (ETC) convert redox energy into the proton motive force (ΔP), which is subsequently used by the ATP synthase to regenerate ATP. The limited available redox free energy requires the proton pumps to operate close to equilibrium in order to maintain a high ΔP, which in turn is needed to maintain a high phosphorylation potential. Current biochemical assays measure complex activities far from equilibrium and so shed little light on their function under physiological conditions. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.013DOI Listing
January 2019
11 Reads

Atomistic insights into cardiolipin binding sites of cytochrome c oxidase.

Biochim Biophys Acta Bioenerg 2019 Mar 8;1860(3):224-232. Epub 2018 Nov 8.

Department of Physics, P. O. Box 64, University of Helsinki, Helsinki 00014, Finland; Institute of Biotechnology, P. O. Box 56, University of Helsinki, Helsinki 00014, Finland. Electronic address:

Mitochondrial cytochrome c oxidase couples the reduction of oxygen to proton pumping. Despite an overall good understanding of its molecular mechanism, the role of cardiolipin in protein function is not understood. Here, we have studied the cardiolipin-protein interactions in a dynamic context by means of atomistic molecular dynamics simulations performed on the entire structure of monomeric and dimeric forms of the enzyme. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.004DOI Listing
March 2019
2 Reads

Spectral microscopic imaging of heterocysts and vegetative cells in two filamentous cyanobacteria based on spontaneous Raman scattering and photoluminescence by 976 nm excitation.

Biochim Biophys Acta Bioenerg 2019 Jan 8;1860(1):78-88. Epub 2018 Nov 8.

Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. Electronic address:

Photosynthetic pigment-protein complexes are highly concentrated in thylakoid membranes of chloroplasts and cyanobacteria that emit strong autofluorescence (mainly 600-800 nm). In Raman scattering microscopy that enables imaging of pigment concentrations of thylakoid membranes, near infrared laser excitation at 1064 nm or visible laser excitation at 488-532 nm has been often employed in order to avoid the autofluorescence. Here we explored a new approach to Raman imaging of thylakoid membranes by using excitation wavelength of 976 nm. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.012DOI Listing
January 2019

Energy transfer dynamics in a red-shifted violaxanthin-chlorophyll a light-harvesting complex.

Biochim Biophys Acta Bioenerg 2019 Feb 8;1860(2):111-120. Epub 2018 Nov 8.

Institute of Physics, Faculty of Science, University of South Bohemia, Branišovská 1760, 37005 České Budějovice, Czech Republic; Institute of Plant Molecular Biology, Biological Centre, Czech Academy of Sciences, Branišovská 31, České Budějovice, Czech Republic. Electronic address:

Photosynthetic eukaryotes whose cells harbor plastids originating from secondary endosymbiosis of a red alga include species of major ecological and economic importance. Since utilization of solar energy relies on the efficient light-harvesting, one of the critical factors for the success of the red lineage in a range of environments is to be found in the adaptability of the light-harvesting machinery, formed by the proteins of the light-harvesting complex (LHC) family. A number of species are known to employ mainly a unique class of LHC containing red-shifted chlorophyll a (Chl a) forms absorbing above 690 nm. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.006DOI Listing
February 2019
8 Reads

Structure-dynamic and functional relationships in a Li-transporting sodium‑calcium exchanger mutant.

Biochim Biophys Acta Bioenerg 2019 Mar 8;1860(3):189-200. Epub 2018 Nov 8.

Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel. Electronic address:

The cell membrane (NCX) and mitochondrial (NCLX) Na/Ca exchangers control Ca homeostasis. Eleven (out of twelve) ion-coordinating residues are highly conserved among eukaryotic and prokaryotic NCXs, whereas in NCLX, nine (out of twelve) ion-coordinating residues are different. Consequently, NCXs exhibit high selectivity for Na and Ca, whereas NCLX can exchange Ca with either Na or Li. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.015DOI Listing
March 2019
7 Reads

Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1).

Biochim Biophys Acta Bioenerg 2019 Mar 8;1860(3):259-269. Epub 2018 Nov 8.

Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland. Electronic address:

Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these tissues, is the key factor for heat production. Recent molecular aspects of UCP1 structure provide support for the fatty acid cycling model of coupling, i. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.007DOI Listing
March 2019
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Light-adaptive state transitions in the Ross Sea haptophyte Phaeocystis antarctica and in dinoflagellate cells hosting kleptoplasts derived from it.

Biochim Biophys Acta Bioenerg 2019 Jan 8;1860(1):102-110. Epub 2018 Nov 8.

Institute of Biosciences and Applications, NCSR "Demokritos", 15310, Aghia Paraskevi Attikis, Greece.

Light state transitions (STs) is a reversible physiological process that oxygenic photosynthetic organisms use in order to minimize imbalances in the electronic excitation delivery to the reaction centers of Photosystems I and II, and thus to optimize photosynthesis. STs have been studied extensively in plants, green algae, red algae and cyanobacteria, but sparsely in algae with secondary red algal plastids, such as diatoms and haptophytes, despite their immense ecological significance. In the present work, we examine whether the haptophyte alga Phaeocystis antarctica, and dinoflagellate cells that host kleptoplasts derived from P. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.016DOI Listing
January 2019
15 Reads

Functional investigation of an universally conserved leucine residue in subunit a of ATP synthase targeted by the pathogenic m.9176 T>G mutation.

Biochim Biophys Acta Bioenerg 2019 Jan 7;1860(1):52-59. Epub 2018 Nov 7.

Institut de Biochimie et Génétique Cellulaires, CNRS-Bordeaux University (UMR5095), 1 Rue Camille Saint-Saëns, Bordeaux 33077 cedex, France.. Electronic address:

Protons are transported from the mitochondrial matrix to the intermembrane space of mitochondria during the transfer of electrons to oxygen and shuttled back to the matrix by the a subunit and a ring of identical c subunits across the membrane domain (F) of ATP synthase, which is coupled to ATP synthesis. A mutation (m.9176 T > G) of the mitochondrial ATP6 gene that replaces an universally conserved leucine residue into arginine at amino acid position 217 of human subunit a (aLR) has been associated to NARP (Neuropathy, Ataxia and Retinitis Pigmentosa) and MILS (Maternally Inherited Leigh's Syndrome) diseases. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.005DOI Listing
January 2019
20 Reads

Role of the PB-loop in ApcE and phycobilisome core function in cyanobacterium Synechocystis sp. PCC 6803.

Biochim Biophys Acta Bioenerg 2019 Feb 7;1860(2):155-166. Epub 2018 Nov 7.

K.A. Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russia. Electronic address:

The phycobilisome (PBS) is a giant highly-structured pigment-protein antenna of cyanobacteria and red algae. PBS is composed of the phycobiliproteins and several linker polypeptides. The large core-membrane linker protein (L or ApcE) influences many features and functions of PBS and consists of several domains including the chromophorylated PB-domain. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.10.004DOI Listing
February 2019

Cytochrome c is the main respiratory and photosynthetic soluble electron donor in heterocysts of the cyanobacterium Anabaena sp. PCC 7120.

Biochim Biophys Acta Bioenerg 2019 Jan 7;1860(1):60-68. Epub 2018 Nov 7.

Instituto de Bioquímica Vegetal y Fotosíntesis, cicCartuja, Universidad de Sevilla and CSIC, Sevilla, Spain; Departamento de Bioquímica Vegetal y Biología Molecular, Universidad de Sevilla, Sevilla, Spain. Electronic address:

Cytochrome c is a soluble electron carrier, present in all known cyanobacteria, that has been replaced by plastocyanin in plants. Despite their high structural differences, both proteins have been reported to be isofunctional in cyanobacteria and green algae, acting as alternative electron carriers from the cytochrome b-f complex to photosystem I or terminal oxidases. We have investigated the subcellular localization of both cytochrome c and plastocyanin in the heterocyst-forming cyanobacterium Anabaena sp. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.009DOI Listing
January 2019
7 Reads

Assessing the role of residue E73 and lipid headgroup charge in VDAC1 voltage gating.

Biochim Biophys Acta Bioenerg 2019 Jan 6;1860(1):22-29. Epub 2018 Nov 6.

Section on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

The voltage-dependent anion channel (VDAC) is the most abundant protein of the mitochondrial outer membrane (MOM) where it regulates transport of ions and metabolites in and out of the organelle. VDAC function is extensively studied in a lipid bilayer system that allows conductance monitoring of reconstituted channels under applied voltage. The process of switching from a high-conductance state, open to metabolites, to a variety of low-conducting states, which excludes metabolite transport, is termed voltage gating and the mechanism remains poorly understood. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.11.001DOI Listing
January 2019
14 Reads

Significance of MccR, MccC, MccD, MccL and 8-methylmenaquinone in sulfite respiration of Wolinella succinogenes.

Biochim Biophys Acta Bioenerg 2019 Jan 18;1860(1):12-21. Epub 2018 Oct 18.

Microbial Energy Conversion and Biotechnology, Department of Biology, Technische Universität Darmstadt, Schnittspahnstraße 10, 64287 Darmstadt, Germany. Electronic address:

Reduction of sulfite to sulfide is an essential step in the biogeochemical sulfur cycle. The Epsilonproteobacterium Wolinella succinogenes uses the copper-containing octahaem cytochrome c sulfite reductase MccA to respire sulfite. MccA is encoded by the first gene of the mcc gene cluster, whose transcription is apparently induced by the two-component regulatory system MccRS. Read More

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http://dx.doi.org/10.1016/j.bbabio.2018.10.002DOI Listing
January 2019
9 Reads