276 results match your criteria Biochemistry research international[Journal]


Effects of Tormentic Acid and the Extracts from on the Production of Extracellular Proteases by .

Biochem Res Int 2020 21;2020:6926320. Epub 2020 Apr 21.

Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe.

is among the common nosocomial pathogens. Antibiotics have been used to treat infections. However, there has been increased mortality associated with drug-resistant strains of . Read More

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http://dx.doi.org/10.1155/2020/6926320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211245PMC

The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan.

Biochem Res Int 2020 28;2020:5729389. Epub 2020 Apr 28.

No. 1650, Taiwan Boulevard Section 4, Xitun District, Division of Breast Surgery, Department of Surgery, Taichung Veterans General Hospital, 40705 Taichung, Taiwan.

Breast cancer is a global issue regarding women's health, and high incident rates remain in the Taiwanese female population. Chemotherapy, using anthracycline-based chemotherapeutic agents in neoadjuvant settings, has been introduced as a promising new therapeutic option for treatment of invasive breast cancer. Set apart from conventional anthracycline regimens such as epirubicin, pegylated liposomal doxorubicin (Lipo-Dox®, PLD) was introduced for providing a justifiable treatment effect, while offering a favorable toxicity profile for breast cancer patients in a metastatic setting. Read More

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http://dx.doi.org/10.1155/2020/5729389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204388PMC

The Safety and Efficiency of Tirofiban in Acute Ischemic Stroke Patients Treated with Mechanical Thrombectomy: A Multicenter Retrospective Cohort Study.

Biochem Res Int 2020 27;2020:5656173. Epub 2020 Apr 27.

Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.

Introduction: Limited comparative studies have reported the safety and efficacy of tirofiban in acute ischemic stroke (AIS) patients after mechanical thrombectomy (MT). Additionally, the available studies are inconsistent with each other, which makes application of tirofiban unclear in neuro-intervention. Here, we performed a comparative retrospective study to investigate whether tirofiban combined with MT improves short- and long-term prognosis in AIS patients and whether its use is associated with complications. Read More

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http://dx.doi.org/10.1155/2020/5656173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211241PMC

Application of L. and L. Extracts in Coagulation of Milk: The Case of Traditional Practice in Ab'ala Area, Afar Regional State, Ethiopia.

Biochem Res Int 2020 7;2020:9874949. Epub 2020 Apr 7.

Raya University, Maichew, Tigray Region, Ethiopia.

People living in and around Ab'ala area of the Afar Regional State, Ethiopia, have a traditional practice of applying leaf and fruit extracts to milk in order to coagulate it as soon as possible. Thus, to investigate the role of the extracts in the coagulation of milk and their health threats, the milk-clotting activity, phytochemical screening tests, antimicrobial activities by the agar well diffusion method, and heavy metal content by ICP-OES technique were determined. Accordingly, both and were found to possess phenolics, saponins, and tannins. Read More

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http://dx.doi.org/10.1155/2020/9874949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166260PMC

Flavonoid-Rich Extract of Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage.

Biochem Res Int 2020 31;2020:7656127. Epub 2020 Mar 31.

Department of Pharmacology, School of Pharmacy, University of Ghana, Legon, Accra, Ghana.

is a plant in the family Melastomataceae. The methanolic extract of the whole plant is reported to be rich in C-glycosylflavones such as vitexin and orientin. Though there are several reports on the ethnomedicinal use of this plant extract in stomach ulcers, experimental-based data is unavailable. Read More

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http://dx.doi.org/10.1155/2020/7656127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152943PMC

Energy Requirement of Patients Undergoing Hemodialysis: A Cross-Sectional Study in Multiple Centers.

Biochem Res Int 2020 21;2020:2054265. Epub 2020 Mar 21.

School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan.

Background: Energy requirements must be estimated before nutritional care can be provided for patients undergoing hemodialysis (HD). However, the recommended caloric intake for patients has not been conclusively determined because of insufficiently large sample sizes.

Method: This cross-sectional observational study recruited patients undergoing long-term HD from multiple centers as well as people in the general population without chronic kidney disease. Read More

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http://dx.doi.org/10.1155/2020/2054265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115188PMC

Long-Term Efficacy and Complications of Radiofrequency Thermocoagulation at Different Temperatures for the Treatment of Trigeminal Neuralgia.

Biochem Res Int 2020 4;2020:3854284. Epub 2020 Mar 4.

Department of Pain Management, Shengjing Hospital of China Medical School, No. 36, Sanhao Street, Heping District, Shenyang 110004, China.

Trigeminal neuralgia (TN) is a common neuropathic pain that seriously affects the daily life of patients. Many invasive treatments are currently available for patients who respond poorly to oral carbamazepine or oxcarbazepine. Among them, radiofrequency (RF) treatment is a viable option with reliable initial and long-term clinical efficacy. Read More

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http://dx.doi.org/10.1155/2020/3854284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077036PMC

Single-Nucleotide Polymorphisms in are Associated with Noise-Induced Hearing Loss in a Chinese Population.

Biochem Res Int 2020 17;2020:9589310. Epub 2020 Feb 17.

Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China.

Objectives: The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3'UTR of gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.

Methods: We conducted a case-control study involving 1040 cases and 1060 controls. The effects of SNPs on gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on. Read More

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http://dx.doi.org/10.1155/2020/9589310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048908PMC
February 2020

Methylated Flavonols from J.F.Gmel. and Their Antimicrobial and Antioxidant Activities.

Biochem Res Int 2020 18;2020:4812312. Epub 2020 Feb 18.

Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Street, Hanoi, Vietnam.

Methylated flavonols form a special group with modulating biological activities in comparison with kaempferol and quercetin. The present study isolated ten compounds including two kaempferol methyl ethers: 5-hydroxy-3,7,4'-trimethoxyflavone (), 3-hydroxy-5,7,4'-trimethoxyflavone (); four quercetin methyl ethers: retusin (5-hydroxy-3,7,3',4'-tetramethoxyflavone) (), 3,5-dihydroxy-7,3',4'-trimethoxyflavone (), 3,4'-dihydroxy-5,7,3'-trimethoxyflavone (), and 3,5,7,3',4'-pentamethoxyflavone (); -sitosterol (); 5-hydroxy-1-(4'-hydroxyphenyl)eicosan-3-one (); -hydroquinone (); and vanillic acid () from the rhizomes and fruit of J.F. Read More

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http://dx.doi.org/10.1155/2020/4812312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049450PMC
February 2020

The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways.

Biochem Res Int 2020 11;2020:4186308. Epub 2020 Feb 11.

Department of Orthopedics, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 100191, China.

Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking. Rab proteins alternate between an activated (GTP-bound) state and an inactivated (GDP-bound) state. Early endosome marker Rab5 GTPase, a key member of the Rab family, plays a crucial role in endocytosis and membrane transport. Read More

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http://dx.doi.org/10.1155/2020/4186308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036122PMC
February 2020

Animal Models of Osteochondral Defect for Testing Biomaterials.

Biochem Res Int 2020 28;2020:9659412. Epub 2020 Jan 28.

Translational Medicine R&D Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

The treatment of osteochondral defects (OCD) remains a great challenge in orthopaedics. Tissue engineering holds a good promise for regeneration of OCD. In the light of tissue engineering, it is critical to establish an appropriate animal model to evaluate the degradability, biocompatibility, and interaction of implanted biomaterials with host bone/cartilage tissues for OCD repair . Read More

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http://dx.doi.org/10.1155/2020/9659412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007938PMC
January 2020

Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Fresen. (Combretaceae) against in Mice.

Biochem Res Int 2020 22;2020:9749410. Epub 2020 Jan 22.

Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. Evergrowing resistance towards the currently available antimalarial drugs is a challenge to combat malaria. Medicinal plants are a promising source of new drugs to tackle this problem. Read More

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http://dx.doi.org/10.1155/2020/9749410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001668PMC
January 2020

miR-142-5p as a CXCR4-Targeted MicroRNA Attenuates SDF-1-Induced Chondrocyte Apoptosis and Cartilage Degradation via Inactivating MAPK Signaling Pathway.

Biochem Res Int 2020 24;2020:4508108. Epub 2020 Jan 24.

Department of Pharmacy, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China.

Osteoarthritis (OA) is a chronic joint function disorder with characteristics of chondrocytes reduction and extracellular matrix (ECM) components destruction. MicroRNAs (miRNAs) and the SDF-1/CXCR4 axis are essential factors of chondrocyte apoptosis and ECM degeneration. However, very few studies have investigated the correlation between miRNAs and the SDF-1/CXCR4 axis in osteoarthritis so far. Read More

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http://dx.doi.org/10.1155/2020/4508108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003277PMC
January 2020

Protein Binding Characteristics of the Principal Green Tea Catechins: A QCM Study Comparing Crude Extract to Pure EGCG.

Biochem Res Int 2019 30;2019:6154170. Epub 2019 Oct 30.

Department of Mechanical Engineering, Bradley University, Peoria, IL, USA.

Label-free detection methods such as the quartz crystal microbalance (QCM) are well suited to the analysis of molecular interactions in complex mixtures such as crude botanical extracts. In the present study, the binding characteristics of epigallocatechin gallate (EGCG) and crude green tea extract solutions to bovine serum albumin (BSA) have been investigated. The adsorbed mass levels onto BSA-functionalized surfaces were measured at various solution concentrations. Read More

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http://dx.doi.org/10.1155/2019/6154170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881586PMC
October 2019

Phytochemical, Antimicrobial, and Antioxidant Profiles of L. Parts.

Biochem Res Int 2019 24;2019:8731595. Epub 2019 Oct 24.

Department of Veterinary Pathology, University of Ibadan, Ibadan, Nigeria.

The use of plant-based medicine is popular amongst individuals and communities in developing countries. has been used in Africa and Asia to treat a wide range of diseases. This study evaluated the phytochemical profile and antioxidant and antimicrobial activities of to ascertain its health benefits in traditional medicine. Read More

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http://dx.doi.org/10.1155/2019/8731595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855089PMC
October 2019

The Binding Affinity of Small Molecules with Yam Tyrosinase (Catechol Oxidase): A Biophysical Study.

Biochem Res Int 2019 10;2019:8284968. Epub 2019 Oct 10.

Department of Biotechnology, Shivaji University, Kolhapur 416004, India.

Yam tyrosinase has become an economically essential enzyme due to its ease of purification and abundant availability of yam tubers. However, an efficient biochemical and biophysical characterization of yam tyrosinase has not been reported. In the present study, the interaction of yam () tyrosinase was studied with molecules such as crocin (), hydroquinone, and kojic acid. Read More

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http://dx.doi.org/10.1155/2019/8284968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811792PMC
October 2019

Chemical Composition, Total Phenolic Content, and Antioxidant Activities of the Essential Oils of the Leaves and Fruit Pulp of L. (Soursop) from Ghana.

Biochem Res Int 2019 2;2019:4164576. Epub 2019 Sep 2.

Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

, also called soursop, is widespread in many tropical countries, and various parts of the plant have been shown to possess very good pharmacological properties. This work evaluated the chemical composition and antioxidant activities of essential oils obtained from the fruit pulp and leaves of soursop. Essential oils were obtained via hydrodistillation and characterized by gas chromatography-mass spectrometry. Read More

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http://dx.doi.org/10.1155/2019/4164576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745133PMC
September 2019

Synthesis of Surfactants Derived from 2-Mercaptobenzimidazole and Study of Their Acute Toxicity and Analgesic and Psychotropic Activities.

Biochem Res Int 2019 30;2019:9615728. Epub 2019 Jul 30.

Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, BP 6203 Rabat-Institutes, Rabat, Morocco.

The aim of the present study is to synthesize cationic salts from a relatively toxic compound named 2-mercaptobenzimidazole and to evaluate some of their pharmacological properties. The acute toxicity of these salts is evaluated according to OECD 423 Guidelines at the doses of 300 and 2000 mg/kg; their peripheral analgesic effect is studied using the Koster test at the therapeutic dose of 200 mg/kg and their sedative action is evaluated using Traction, Chimney, Hole-board, and Rotarod tests at the doses of 200 and 400 mg/kg. All synthesized molecules show no acute toxicity according to OECD Code 423 guidelines at doses ranging from 300 to 2000 mg/kg and do not cause any obesity or anorexia. Read More

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http://dx.doi.org/10.1155/2019/9615728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701276PMC

Integrated Analysis of Oncogenic Networks in Colorectal Cancer Identifies GUCA2A as a Molecular Marker.

Biochem Res Int 2019 28;2019:6469420. Epub 2019 Jul 28.

Research Center for Clinical Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing 210000, Jiangsu, China.

Colorectal cancer (CRC) is one of the most common and deadly malignancies in the world. In China, the morbidity rate of CRC has increased during the period 2000 to 2011. Biomarker detection for early CRC diagnosis can effectively reduce the mortality of patients with CRC. Read More

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http://dx.doi.org/10.1155/2019/6469420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701329PMC

Cryptolepine, the Main Alkaloid of the Antimalarial (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos.

Biochem Res Int 2019 8;2019:7076986. Epub 2019 Jul 8.

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: Previous studies on cryptolepine, the antimalarial and cytotoxic alkaloid of , showed that it preferentially accumulates in rapidly proliferating cells and melanin-containing tissues. Subsequently, we demonstrated that cryptolepine was toxic to murine embryos but no signs of teratogenicity. developmental studies can be confounded by maternal effects. Read More

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http://dx.doi.org/10.1155/2019/7076986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644280PMC
July 2019
5 Reads

Phytochemical Screening of Essential Oils and Antibacterial Activity and Antioxidant Properties of (L) Leaf Extract.

Biochem Res Int 2019 12;2019:7143989. Epub 2019 Feb 12.

Faculty of Resource Science and Technology, University of Malaysia Sarawak, Kuching, Kota Samarahan, Malaysia.

Objective: To ascertain the essential oil phytochemicals of the leaf and to test for the antibacterial and antioxidant properties of dichloromethane crude extract of leaf.

Methods: The phytochemical screening of essential oils, extraction by hydrodistillation using the Clevenger apparatus, and analysis performed by gas chromatography equipped with a flame ionization detector (GC-FID). Antibacterial activity and the inhibition rate (mm) were determined using the agar disc method against four bacterial strains using tetracycline as positive control. Read More

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http://dx.doi.org/10.1155/2019/7143989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390260PMC
February 2019
2 Reads

Impact of Alkaline Pretreatment to Enhance Volatile Fatty Acids (VFAs) Production from Rice Husk.

Biochem Res Int 2019 23;2019:8489747. Epub 2019 Jan 23.

Department of Municipal Engineering, College of Civil Engineering, Guangzhou University, Guangzhou 510006, China.

This study explores the use of alkaline pretreatments to improve the hydrolyzation of rice husks to produce volatile fatty acids (VFAs). The study investigated the effects of reagent concentration and pretreatment time on protein, carbohydrates, and dissolved chemical oxygen demand (SCOD) dissolution after the pretreatment. The optimum alkaline pretreatment conditions were 0. Read More

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http://dx.doi.org/10.1155/2019/8489747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364127PMC
January 2019
2 Reads

Leaf-Methanolic Extract of (Araliaceae) (L. F. Phillipson) Reverses Amitriptyline-Induced Sexual Dysfunction in Male Rats.

Biochem Res Int 2018 15;2018:2869727. Epub 2018 Nov 15.

Animal Physiology and Phytopharmacology Laboratory, Department of Animal Biology, Faculty of Science, University of Dschang, Dschang, Cameroon.

The people of the Bayangi tribe (Manyu Division) of Cameroon have used the leaves of (Araliaceae) traditionally for decades as an aphrodisiac. In order to scientifically investigate this folk claim, we evaluated the effects of the leaf-aqueous extract of on the sexual behavior of normal male rats. The present study was designed to assess the effects of the leaf-methanolic extract of on amitriptyline-induced sexual dysfunction in male rats. Read More

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http://dx.doi.org/10.1155/2018/2869727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276499PMC
November 2018

The Cardio- and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage.

Biochem Res Int 2018 3;2018:9302414. Epub 2018 Sep 3.

SI "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine", Dnipro, Ukraine.

Heart diseases, especially acute coronary syndrome (ACS), are among the most severe illnesses that often lead to death. Despite significant advances in the prevention and treatment of ACS, the incidence of the disease and its complications are very serious. The imbalance between pro- and antioxidant systems, the formation of active carbonyl compounds, and the end products of glycation in the blood and tissues are the key moments in the development of heart and neurological disorders leading to a change of behavioral responses. Read More

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http://dx.doi.org/10.1155/2018/9302414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140133PMC
September 2018
2 Reads

Molecular Modeling of Antimalarial Agents by 3D-QSAR Study and Molecular Docking of Two Hybrids 4-Aminoquinoline-1,3,5-triazine and 4-Aminoquinoline-oxalamide Derivatives with the Receptor Protein in Its Both Wild and Mutant Types.

Biochem Res Int 2018 24;2018:8639173. Epub 2018 Jun 24.

Engineering Materials, Modeling and Environmental Laboratory, Faculty of Sciences of Dhar Elmehraz, Sidi Mohammed Ben Abdellah University, B.P. 1796, Atlas, Fes, Morocco.

Modeling studies using 3D-QSAR and molecular docking methods were performed on a set of 34 hybrids of 4-aminoquinoline derivatives previously studied as effective antimalarial agents of wild type and quadruple mutant dihydrofolate reductase (DHFR). So, the famous mathematical method multiple linear regression (MLR) was explored to build the QSAR model. The DFT-B3LYP method with the basis set 6-31G was used to calculate the quantum chemical descriptors, chosen to represent the electronic descriptors of molecular structures. Read More

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http://dx.doi.org/10.1155/2018/8639173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035821PMC
June 2018
40 Reads

Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex.

Biochem Res Int 2018 9;2018:6406372. Epub 2018 Jan 9.

School of Biological Science and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea.

Med6 protein (Med6p) is a hallmark component of evolutionarily conserved Mediator complexes, and the genuine role of Med6p in Mediator functions remains elusive. For the functional analysis of Med6p (scMed6p), we generated a series of scMed6p mutants harboring a small internal deletion. Genetic analysis of these mutants revealed that three regions (amino acids 33-42 (Δ2), 125-134 (Δ5), and 157-166 (Δ6)) of scMed6p are required for cell viability and are located at highly conserved regions of Med6 homologs. Read More

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http://dx.doi.org/10.1155/2018/6406372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818915PMC
January 2018
2 Reads

Influences of on the CYP450 Activities in Rats Using a Cocktail Method by UHPLC-MS/MS.

Biochem Res Int 2018 3;2018:1467143. Epub 2018 Apr 3.

Department of Pharmacology, Jinhua Polytechnic, Zhejiang, China.

has been used to treat various cancers. Cytochrome P450, a drug metabolic enzyme, might be influenced by herbal medicine. Currently, the problem that remains is the effective treatment in drug-drug interaction situation. Read More

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http://dx.doi.org/10.1155/2018/1467143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903335PMC
April 2018
1 Read

Bioactivity and Toxicity of and Extracts.

Biochem Res Int 2018 2;2018:8074306. Epub 2018 Apr 2.

Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, 60021-970 Fortaleza, CE, Brazil.

This work investigated the content of total polyphenolic compounds and flavonoids as well as their toxicity and larvicidal and acetylcholinesterase inhibitory activities. The antioxidant activities of two medicinal species extracts ( and ) were also investigated. The ethanol extract of the leaves of and the ethanol extract of the branches of presented the best performance in the DPPH/FRAP and ABTS/ORAC assays, respectively. Read More

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http://dx.doi.org/10.1155/2018/8074306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902074PMC
April 2018
6 Reads

Streptozotocin-Induced Adaptive Modification of Mitochondrial Supercomplexes in Liver of Wistar Rats and the Protective Effect of Lam.

Biochem Res Int 2018 1;2018:5681081. Epub 2018 Mar 1.

Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango Campus, Gómez Palacio, DGO, Mexico.

The increasing prevalence of diabetes continues to be a major health issue worldwide. Alteration of mitochondrial electron transport chain is a recognized hallmark of the diabetic-associated decline in liver bioenergetics; however, the molecular events involved are only poorly understood. is used for the treatment of diabetes. Read More

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http://dx.doi.org/10.1155/2018/5681081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852898PMC
March 2018
8 Reads
1 Citation

Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers.

Biochem Res Int 2018 1;2018:7463796. Epub 2018 Feb 1.

Preventive and Community Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA.

Type 2 diabetes mellitus (T2DM) is emerging as a metabolic epidemic worldwide. Pathologically, dysregulation of many biological pathways precedes hyperglycemia and the clinical diagnosis of T2DM. Changing trajectories along the process of T2DM development necessitates frequent measurement of biomarkers for early identification of at-risk individuals and successful prevention. Read More

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http://dx.doi.org/10.1155/2018/7463796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816886PMC
February 2018
2 Reads

Genistein Exposure Interferes with Pharmacokinetics of Celecoxib in SD Male Rats by UPLC-MS/MS.

Biochem Res Int 2017 4;2017:6510232. Epub 2017 Dec 4.

School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objective: To discuss the effects of genistein on the metabolism of celecoxib in vitro and in vivo.

Method: In vitro, the effects of genistein on the metabolism of celecoxib were studied using rat and human liver microsomes. In vivo, pharmacokinetics of celecoxib was evaluated in rats with or without genistein. Read More

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http://dx.doi.org/10.1155/2017/6510232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745716PMC
December 2017
5 Reads

Biochemical Analysis of Histone Succinylation.

Biochem Res Int 2017 1;2017:8529404. Epub 2017 Nov 1.

Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

Posttranslational modification (PTM) of proteins is used to regulate protein activity and stability. Histone PTMs are regarded as some of the most important, as they can directly regulate gene expression through chromatin reorganization. Recently, histone proteins were found to undergo succinylation, adding to other well-known PTMs such as acetylation, methylation, and phosphorylation. Read More

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http://dx.doi.org/10.1155/2017/8529404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684591PMC
November 2017
2 Reads

Antioxidant and Antiradical Properties of Selected Flavonoids and Phenolic Compounds.

Biochem Res Int 2017 12;2017:7616791. Epub 2017 Oct 12.

Department of Chemistry, Faculty of Sciences, Atatürk University, 25240 Erzurum, Turkey.

Phenolic compounds and flavonoids are known by their antioxidant properties and one of the most important sources for humans is the diet. Due to the harmful effects of synthetic antioxidants such as BHA and BHT, natural novel antioxidants have become the focus of attention for protecting foods and beverages and reducing oxidative stress . In the current study, we investigated the total antioxidant, metal chelating, Fe and Cu reduction, and free radical scavenging activities of some phenolic and flavonoid compounds including malvin, oenin, ID-8, silychristin, callistephin, pelargonin, 3,4-dihydroxy-5-methoxybenzoic acid, 2,4,6-trihydroxybenzaldehyde, and arachidonoyl dopamine. Read More

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http://dx.doi.org/10.1155/2017/7616791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660747PMC
October 2017
55 Reads

Evaluation of Essential Oils Derived from (Piperaceae) and (Rutaceae) against the Tick (Acari: Ixodidae).

Biochem Res Int 2017 8;2017:5342947. Epub 2017 Oct 8.

Laboratório de Estudos em Pragas e Parasitos, Universidade Federal Fluminense, IB, Departamento de Biologia Celular e Molecular-GCM, Niterói, RJ, Brazil.

The present research aimed to study the chemical composition and acaricidal activity of and essential oils against the cattle tick . GC-MS analysis of essential oil showed limonene (50.3%), -pinene (14. Read More

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http://dx.doi.org/10.1155/2017/5342947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651092PMC
October 2017
37 Reads

The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats.

Biochem Res Int 2017 28;2017:9478958. Epub 2017 Aug 28.

Department of Chemistry, Faculty of Science and Literature, Harran University, Sanliurfa, Turkey.

The aim of this study is to examine the protective effect of naringenin-oxime (NOX) on cisplatin-induced major organ toxicity and DNA damage in rats. Thirty-five male Wistar albino rats were equally split into five groups as follows: control (i.p. Read More

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http://dx.doi.org/10.1155/2017/9478958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592396PMC
August 2017
4 Reads

Serum Transthyretin Level as a Plausible Marker for Diagnosis of Child Acute Malnutrition.

Biochem Res Int 2017 8;2017:9196538. Epub 2017 Aug 8.

Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.

Malnutrition is a major underlying condition for mortality in children under five years of age in developing countries, particularly in Ethiopia. The most important forms of malnutrition in Ethiopia are protein and energy deficiencies. There is no reliable laboratory method at present to assess acute malnutrition. Read More

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https://www.hindawi.com/journals/bri/2017/9196538/
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http://dx.doi.org/10.1155/2017/9196538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591899PMC
August 2017
32 Reads

Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases.

Biochem Res Int 2017 21;2017:6257240. Epub 2017 Jun 21.

Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100043, China.

To get inside the properties of N,N-disubstituted Schiff bases, we synthesized three high-yielding benzaldehyde Schiff bases. We used the reaction between salicylaldehyde and different diamine compounds, including diamine, ethanediamine, and -phenylenediamine, determining the structure of obtained molecules by nuclear magnetic resonance spectroscopy and electrospray ionization mass spectroscopy. We thus evaluated the microbicidal and antitumor activity of these compounds, showing that salicylaldehyde-hydrazine hydrate Schiff base (compound ) significantly inhibited the growth of ; salicylaldehyde--phenylenediamine Schiff base (compound ) displayed a strong capability to inhibit the proliferation of leukemia cell lines K562 and HEL. Read More

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http://dx.doi.org/10.1155/2017/6257240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497607PMC
June 2017
48 Reads

Elevated Cardiovascular Risks among Postmenopausal Women: A Community Based Case Control Study from Nepal.

Biochem Res Int 2017 2;2017:3824903. Epub 2017 May 2.

Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal.

Cardiovascular disease (CVD) is one of the leading causes of death worldwide which is more prevalent in women after menopause. Hormonal changes associated with menopause are accountable for dyslipidemic pattern that causes CVD and associated complications. Therefore, the present study was commenced to compare the lipid profile in pre- and postmenopausal women. Read More

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http://dx.doi.org/10.1155/2017/3824903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433412PMC
May 2017
41 Reads

Biochemical Content of Cambium of Eaten by Bears on the Far East of Russia.

Biochem Res Int 2017 26;2017:3020571. Epub 2017 Apr 26.

Pacific Geographical Institute FEB RAS, 7 Radio St., Vladivostok 690041, Russia.

The peculiarity of bears behavior of stripping of bark is typical for all species. We have described the damage to trees, by Asiatic black bear and brown bear in Primorsky Krai and by brown bears on the Sakhalin Island during 1998-2015. In this study, we studied the damaged bark of the tree only in cases where it was clear that part of the cambium was eaten by bears. Read More

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http://dx.doi.org/10.1155/2017/3020571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424178PMC
April 2017
5 Reads

Salivary Distinctiveness and Modifications in Males with Diabetes and Behçet's Disease.

Biochem Res Int 2017 21;2017:9596202. Epub 2017 Feb 21.

Department of Oral Medicine, Faculty of Dentistry, University of Damascus, Damascus, Syria.

Oral diseases associated with systematic diseases as metabolic and vasculitic have been included in this paper. This will enhance our understanding of the salivary function in promoting healthy oral condition. The study investigates the effects of type I and type II diabetes mellitus in well-controlled diabetic patients, in addition to on saliva flow rate (SFR), pH, the decay, missing, and filled tooth (DMFT) index, glucose, and major earth-alkaline ions (Ca and Mg) compared to healthy males and age-matched controls. Read More

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http://dx.doi.org/10.1155/2017/9596202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339495PMC
February 2017
273 Reads

Protective Effect of Edaravone against Carbon Monoxide Induced Apoptosis in Rat Primary Cultured Astrocytes.

Biochem Res Int 2017 2;2017:5839762. Epub 2017 Feb 2.

Department of Rehabilitation Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China.

. To observe the protective effect of edaravone (Eda) on astrocytes after prolonged exposure to carbon monoxide (CO) and further to investigate the potential mechanisms of Eda against CO-induced apoptosis. . Read More

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http://dx.doi.org/10.1155/2017/5839762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312051PMC
February 2017
9 Reads

In Vitro and In Vivo Effects of Norathyriol and Mangiferin on -Glucosidase.

Biochem Res Int 2017 10;2017:1206015. Epub 2017 Jan 10.

Institute of Drug Discovery & Development, Kunming Pharmaceutical Corporation, Kunming 650106, China.

Norathyriol is a metabolite of mangiferin. Mangiferin has been reported to inhibit -glucosidase. To the best of our knowledge, no study has been conducted to determine or compare those two compounds on inhibiting -glucosidase in vitro and in vivo by far. Read More

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http://dx.doi.org/10.1155/2017/1206015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259675PMC
January 2017
5 Reads

Molecular Evolution of the Glycosyltransferase 6 Gene Family in Primates.

Biochem Res Int 2016 4;2016:9051727. Epub 2016 Dec 4.

Laboratório de Biologia Molecular "Francisco Mauro Salzano", Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.

Glycosyltransferase 6 gene family includes ABO, Ggta1, iGb3S, and GBGT1 genes and by three putative genes restricted to mammals, GT6m6, GTm6, and GT6m7, only the latter is found in primates. GT6 genes may encode functional and nonfunctional proteins. Ggta1 and GBGT1 genes, for instance, are pseudogenes in catarrhine primates, while iGb3S gene is only inactive in human, bonobo, and chimpanzee. Read More

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http://dx.doi.org/10.1155/2016/9051727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164903PMC
December 2016
10 Reads

Crystal Structures of Two Isozymes of Citrate Synthase from Sulfolobus tokodaii Strain 7.

Biochem Res Int 2016 30;2016:7560919. Epub 2016 Aug 30.

Department of Physics, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.

Thermoacidophilic archaeon Sulfolobus tokodaii strain 7 has two citrate synthase genes (ST1805-CS and ST0587-CS) in the genome with 45% sequence identity. Because they exhibit similar optimal temperatures of catalytic activity and thermal inactivation profiles, we performed structural comparisons between these isozymes to elucidate adaptation mechanisms to high temperatures in thermophilic CSs. The crystal structures of ST1805-CS and ST0587-CS were determined at 2. Read More

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http://dx.doi.org/10.1155/2016/7560919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021468PMC
September 2016
6 Reads

Presynaptic Proteins as Markers of the Neurotoxic Activity of BmjeTX-I and BmjeTX-II Toxins from Bothrops marajoensis (Marajó Lancehead) Snake Venom.

Biochem Res Int 2016 18;2016:2053459. Epub 2016 Aug 18.

Multidisciplinary Research Laboratory, São Francisco University (USF), Avenida São Francisco de Assis 218, Jardim São José, 12916-350 Bragança Paulista, SP, Brazil; Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Cidade Universitária Zeferino Vaz, 13083-365 Campinas, SP, Brazil.

Neuromuscular preparations exposed to B. marajoensis venom show increases in the frequency of miniature end-plate potentials and twitch tension facilitation followed by presynaptic neuromuscular paralysis, without evidences of muscle damage. Considering that presynaptic toxins interfere into the machinery involved in neurotransmitter release (synaptophysin, synaptobrevin, and SNAP25 proteins), the main objective of this communication is to analyze, by immunofluorescence and western blotting, the expression of the synaptic proteins, synaptophysin, synaptobrevin, and SNAP25 and by myography, light, and transmission electron microscopy the pathology of motor nerve terminals and skeletal muscle fibres of chick biventer cervicis preparations (CBC) exposed in vitro to BmjeTX-I and BmjeTX-II toxins from B. Read More

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http://dx.doi.org/10.1155/2016/2053459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007310PMC
September 2016
16 Reads

Urinary Markers of Tubular Injury in HIV-Infected Patients.

Biochem Res Int 2016 17;2016:1501785. Epub 2016 Jul 17.

Department of Clinical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Renal disease is a common complication of HIV-infected patients, associated with increased risk of cardiovascular events, progression to AIDS, AIDS-defining illness, and mortality. Early and accurate identification of renal disease is therefore crucial to improve patient outcomes. The use of serum creatinine, along with proteinuria, to detect renal involvement is essentially to screen for markers of glomerular disease and may not be effective in detecting earlier stages of renal injury. Read More

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http://dx.doi.org/10.1155/2016/1501785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967446PMC
August 2016
5 Reads
1 Citation

A Bioinformatics Analysis Reveals a Group of MocR Bacterial Transcriptional Regulators Linked to a Family of Genes Coding for Membrane Proteins.

Biochem Res Int 2016 30;2016:4360285. Epub 2016 Jun 30.

Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, 00185 Roma, Italy.

The MocR bacterial transcriptional regulators are characterized by an N-terminal domain, 60 residues long on average, possessing the winged-helix-turn-helix (wHTH) architecture responsible for DNA recognition and binding, linked to a large C-terminal domain (350 residues on average) that is homologous to fold type-I pyridoxal 5'-phosphate (PLP) dependent enzymes like aspartate aminotransferase (AAT). These regulators are involved in the expression of genes taking part in several metabolic pathways directly or indirectly connected to PLP chemistry, many of which are still uncharacterized. A bioinformatics analysis is here reported that studied the features of a distinct group of MocR regulators predicted to be functionally linked to a family of homologous genes coding for integral membrane proteins of unknown function. Read More

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http://dx.doi.org/10.1155/2016/4360285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944035PMC
July 2016
5 Reads

Potential Properties of Plant Sprout Extracts on Amyloid β.

Biochem Res Int 2016 27;2016:9347468. Epub 2016 Jun 27.

Laboratory on Ageing & Health Management, Graduate School of Nursing & Health, Aichi Prefectural University, Tohgoku, Kamishidami, Moriyama, Nagoya 463-8502, Japan.

The aim of this study is to examine the amyloid β (Aβ) inhibition mechanism of plant sprouts' aqueous extracts (PSAE). In this study, we screened the effects of five plant sprouts' extracts on Aβ (1-42) structure modification using gel electrophoresis. In PSAE, no band of Aβ monomer was recognized in Japanese butterbur. Read More

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http://dx.doi.org/10.1155/2016/9347468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939385PMC
July 2016
1 Read

Cetuximab and Cisplatin Show Different Combination Effect in Nasopharyngeal Carcinoma Cells Lines via Inactivation of EGFR/AKT Signaling Pathway.

Biochem Res Int 2016 24;2016:7016907. Epub 2016 May 24.

The Fourth Clinical School of Nanjing Medical University, Nanjing 210009, China; Department of Radiation Oncology, Nanjing Medical University Affiliated Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, China; Xuzhou Medical College, Xuzhou 210009, China.

Nasopharyngeal carcinoma (NPC) is a common malignant cancer in South China. Cisplatin is a classical chemotherapeutic employed for NPC treatment. Despite the use of cisplatin-based concurrent chemoradiotherapy, distant failure still confuses clinicians and the outcome of metastatic NPC remains disappointing. Read More

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http://www.hindawi.com/journals/bri/2016/7016907/
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http://dx.doi.org/10.1155/2016/7016907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894995PMC
June 2016
5 Reads

Production of Laccase by Cochliobolus sp. Isolated from Plastic Dumped Soils and Their Ability to Degrade Low Molecular Weight PVC.

Biochem Res Int 2016 12;2016:9519527. Epub 2016 May 12.

Department of Virology and DST-PURSE Centre, Sri Venkateswara University, Tirupati 517502, India.

One of the utmost man-made problems faced today has been the ever-increasing plastic waste filling the world. It accounts for an estimated 20-30% (by volume) of municipal solid waste in landfill sites worldwide. Research on plastic biodegradation has been steadily growing over the past four decades. Read More

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http://dx.doi.org/10.1155/2016/9519527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880699PMC
June 2016
1 Read
1 Citation