256 results match your criteria Biochemistry research international[Journal]


Phytochemical Screening of Essential Oils and Antibacterial Activity and Antioxidant Properties of (L) Leaf Extract.

Biochem Res Int 2019 12;2019:7143989. Epub 2019 Feb 12.

Faculty of Resource Science and Technology, University of Malaysia Sarawak, Kuching, Kota Samarahan, Malaysia.

Objective: To ascertain the essential oil phytochemicals of the leaf and to test for the antibacterial and antioxidant properties of dichloromethane crude extract of leaf.

Methods: The phytochemical screening of essential oils, extraction by hydrodistillation using the Clevenger apparatus, and analysis performed by gas chromatography equipped with a flame ionization detector (GC-FID). Antibacterial activity and the inhibition rate (mm) were determined using the agar disc method against four bacterial strains using tetracycline as positive control. Read More

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http://dx.doi.org/10.1155/2019/7143989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390260PMC
February 2019
1 Read

Impact of Alkaline Pretreatment to Enhance Volatile Fatty Acids (VFAs) Production from Rice Husk.

Biochem Res Int 2019 23;2019:8489747. Epub 2019 Jan 23.

Department of Municipal Engineering, College of Civil Engineering, Guangzhou University, Guangzhou 510006, China.

This study explores the use of alkaline pretreatments to improve the hydrolyzation of rice husks to produce volatile fatty acids (VFAs). The study investigated the effects of reagent concentration and pretreatment time on protein, carbohydrates, and dissolved chemical oxygen demand (SCOD) dissolution after the pretreatment. The optimum alkaline pretreatment conditions were 0. Read More

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http://dx.doi.org/10.1155/2019/8489747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364127PMC
January 2019

Leaf-Methanolic Extract of (Araliaceae) (L. F. Phillipson) Reverses Amitriptyline-Induced Sexual Dysfunction in Male Rats.

Biochem Res Int 2018 15;2018:2869727. Epub 2018 Nov 15.

Animal Physiology and Phytopharmacology Laboratory, Department of Animal Biology, Faculty of Science, University of Dschang, Dschang, Cameroon.

The people of the Bayangi tribe (Manyu Division) of Cameroon have used the leaves of (Araliaceae) traditionally for decades as an aphrodisiac. In order to scientifically investigate this folk claim, we evaluated the effects of the leaf-aqueous extract of on the sexual behavior of normal male rats. The present study was designed to assess the effects of the leaf-methanolic extract of on amitriptyline-induced sexual dysfunction in male rats. Read More

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http://dx.doi.org/10.1155/2018/2869727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276499PMC
November 2018

The Cardio- and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage.

Biochem Res Int 2018 3;2018:9302414. Epub 2018 Sep 3.

SI "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine", Dnipro, Ukraine.

Heart diseases, especially acute coronary syndrome (ACS), are among the most severe illnesses that often lead to death. Despite significant advances in the prevention and treatment of ACS, the incidence of the disease and its complications are very serious. The imbalance between pro- and antioxidant systems, the formation of active carbonyl compounds, and the end products of glycation in the blood and tissues are the key moments in the development of heart and neurological disorders leading to a change of behavioral responses. Read More

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http://dx.doi.org/10.1155/2018/9302414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140133PMC
September 2018
1 Read

Molecular Modeling of Antimalarial Agents by 3D-QSAR Study and Molecular Docking of Two Hybrids 4-Aminoquinoline-1,3,5-triazine and 4-Aminoquinoline-oxalamide Derivatives with the Receptor Protein in Its Both Wild and Mutant Types.

Biochem Res Int 2018 24;2018:8639173. Epub 2018 Jun 24.

Engineering Materials, Modeling and Environmental Laboratory, Faculty of Sciences of Dhar Elmehraz, Sidi Mohammed Ben Abdellah University, B.P. 1796, Atlas, Fes, Morocco.

Modeling studies using 3D-QSAR and molecular docking methods were performed on a set of 34 hybrids of 4-aminoquinoline derivatives previously studied as effective antimalarial agents of wild type and quadruple mutant dihydrofolate reductase (DHFR). So, the famous mathematical method multiple linear regression (MLR) was explored to build the QSAR model. The DFT-B3LYP method with the basis set 6-31G was used to calculate the quantum chemical descriptors, chosen to represent the electronic descriptors of molecular structures. Read More

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http://dx.doi.org/10.1155/2018/8639173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035821PMC
June 2018
19 Reads

Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex.

Biochem Res Int 2018 9;2018:6406372. Epub 2018 Jan 9.

School of Biological Science and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea.

Med6 protein (Med6p) is a hallmark component of evolutionarily conserved Mediator complexes, and the genuine role of Med6p in Mediator functions remains elusive. For the functional analysis of Med6p (scMed6p), we generated a series of scMed6p mutants harboring a small internal deletion. Genetic analysis of these mutants revealed that three regions (amino acids 33-42 (Δ2), 125-134 (Δ5), and 157-166 (Δ6)) of scMed6p are required for cell viability and are located at highly conserved regions of Med6 homologs. Read More

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http://dx.doi.org/10.1155/2018/6406372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818915PMC
January 2018
1 Read

Influences of on the CYP450 Activities in Rats Using a Cocktail Method by UHPLC-MS/MS.

Biochem Res Int 2018 3;2018:1467143. Epub 2018 Apr 3.

Department of Pharmacology, Jinhua Polytechnic, Zhejiang, China.

has been used to treat various cancers. Cytochrome P450, a drug metabolic enzyme, might be influenced by herbal medicine. Currently, the problem that remains is the effective treatment in drug-drug interaction situation. Read More

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http://dx.doi.org/10.1155/2018/1467143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903335PMC

Bioactivity and Toxicity of and Extracts.

Biochem Res Int 2018 2;2018:8074306. Epub 2018 Apr 2.

Department of Organic and Inorganic Chemistry, Federal University of Ceará, Pici Campus, 60021-970 Fortaleza, CE, Brazil.

This work investigated the content of total polyphenolic compounds and flavonoids as well as their toxicity and larvicidal and acetylcholinesterase inhibitory activities. The antioxidant activities of two medicinal species extracts ( and ) were also investigated. The ethanol extract of the leaves of and the ethanol extract of the branches of presented the best performance in the DPPH/FRAP and ABTS/ORAC assays, respectively. Read More

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http://dx.doi.org/10.1155/2018/8074306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902074PMC
April 2018
6 Reads

Streptozotocin-Induced Adaptive Modification of Mitochondrial Supercomplexes in Liver of Wistar Rats and the Protective Effect of Lam.

Biochem Res Int 2018 1;2018:5681081. Epub 2018 Mar 1.

Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango Campus, Gómez Palacio, DGO, Mexico.

The increasing prevalence of diabetes continues to be a major health issue worldwide. Alteration of mitochondrial electron transport chain is a recognized hallmark of the diabetic-associated decline in liver bioenergetics; however, the molecular events involved are only poorly understood. is used for the treatment of diabetes. Read More

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http://dx.doi.org/10.1155/2018/5681081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852898PMC
March 2018
4 Reads
1 Citation

Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers.

Biochem Res Int 2018 1;2018:7463796. Epub 2018 Feb 1.

Preventive and Community Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USA.

Type 2 diabetes mellitus (T2DM) is emerging as a metabolic epidemic worldwide. Pathologically, dysregulation of many biological pathways precedes hyperglycemia and the clinical diagnosis of T2DM. Changing trajectories along the process of T2DM development necessitates frequent measurement of biomarkers for early identification of at-risk individuals and successful prevention. Read More

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http://dx.doi.org/10.1155/2018/7463796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816886PMC
February 2018

Genistein Exposure Interferes with Pharmacokinetics of Celecoxib in SD Male Rats by UPLC-MS/MS.

Biochem Res Int 2017 4;2017:6510232. Epub 2017 Dec 4.

School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objective: To discuss the effects of genistein on the metabolism of celecoxib in vitro and in vivo.

Method: In vitro, the effects of genistein on the metabolism of celecoxib were studied using rat and human liver microsomes. In vivo, pharmacokinetics of celecoxib was evaluated in rats with or without genistein. Read More

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http://dx.doi.org/10.1155/2017/6510232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745716PMC
December 2017
3 Reads

Biochemical Analysis of Histone Succinylation.

Biochem Res Int 2017 1;2017:8529404. Epub 2017 Nov 1.

Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

Posttranslational modification (PTM) of proteins is used to regulate protein activity and stability. Histone PTMs are regarded as some of the most important, as they can directly regulate gene expression through chromatin reorganization. Recently, histone proteins were found to undergo succinylation, adding to other well-known PTMs such as acetylation, methylation, and phosphorylation. Read More

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http://dx.doi.org/10.1155/2017/8529404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684591PMC
November 2017

Antioxidant and Antiradical Properties of Selected Flavonoids and Phenolic Compounds.

Biochem Res Int 2017 12;2017:7616791. Epub 2017 Oct 12.

Department of Chemistry, Faculty of Sciences, Atatürk University, 25240 Erzurum, Turkey.

Phenolic compounds and flavonoids are known by their antioxidant properties and one of the most important sources for humans is the diet. Due to the harmful effects of synthetic antioxidants such as BHA and BHT, natural novel antioxidants have become the focus of attention for protecting foods and beverages and reducing oxidative stress . In the current study, we investigated the total antioxidant, metal chelating, Fe and Cu reduction, and free radical scavenging activities of some phenolic and flavonoid compounds including malvin, oenin, ID-8, silychristin, callistephin, pelargonin, 3,4-dihydroxy-5-methoxybenzoic acid, 2,4,6-trihydroxybenzaldehyde, and arachidonoyl dopamine. Read More

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http://dx.doi.org/10.1155/2017/7616791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660747PMC
October 2017
42 Reads

Evaluation of Essential Oils Derived from (Piperaceae) and (Rutaceae) against the Tick (Acari: Ixodidae).

Biochem Res Int 2017 8;2017:5342947. Epub 2017 Oct 8.

Laboratório de Estudos em Pragas e Parasitos, Universidade Federal Fluminense, IB, Departamento de Biologia Celular e Molecular-GCM, Niterói, RJ, Brazil.

The present research aimed to study the chemical composition and acaricidal activity of and essential oils against the cattle tick . GC-MS analysis of essential oil showed limonene (50.3%), -pinene (14. Read More

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http://dx.doi.org/10.1155/2017/5342947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651092PMC
October 2017
15 Reads

The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats.

Biochem Res Int 2017 28;2017:9478958. Epub 2017 Aug 28.

Department of Chemistry, Faculty of Science and Literature, Harran University, Sanliurfa, Turkey.

The aim of this study is to examine the protective effect of naringenin-oxime (NOX) on cisplatin-induced major organ toxicity and DNA damage in rats. Thirty-five male Wistar albino rats were equally split into five groups as follows: control (i.p. Read More

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http://dx.doi.org/10.1155/2017/9478958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592396PMC
August 2017
2 Reads

Serum Transthyretin Level as a Plausible Marker for Diagnosis of Child Acute Malnutrition.

Biochem Res Int 2017 8;2017:9196538. Epub 2017 Aug 8.

Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.

Malnutrition is a major underlying condition for mortality in children under five years of age in developing countries, particularly in Ethiopia. The most important forms of malnutrition in Ethiopia are protein and energy deficiencies. There is no reliable laboratory method at present to assess acute malnutrition. Read More

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https://www.hindawi.com/journals/bri/2017/9196538/
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http://dx.doi.org/10.1155/2017/9196538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591899PMC
August 2017
27 Reads

Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases.

Biochem Res Int 2017 21;2017:6257240. Epub 2017 Jun 21.

Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100043, China.

To get inside the properties of N,N-disubstituted Schiff bases, we synthesized three high-yielding benzaldehyde Schiff bases. We used the reaction between salicylaldehyde and different diamine compounds, including diamine, ethanediamine, and -phenylenediamine, determining the structure of obtained molecules by nuclear magnetic resonance spectroscopy and electrospray ionization mass spectroscopy. We thus evaluated the microbicidal and antitumor activity of these compounds, showing that salicylaldehyde-hydrazine hydrate Schiff base (compound ) significantly inhibited the growth of ; salicylaldehyde--phenylenediamine Schiff base (compound ) displayed a strong capability to inhibit the proliferation of leukemia cell lines K562 and HEL. Read More

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http://dx.doi.org/10.1155/2017/6257240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497607PMC
June 2017
26 Reads

Elevated Cardiovascular Risks among Postmenopausal Women: A Community Based Case Control Study from Nepal.

Biochem Res Int 2017 2;2017:3824903. Epub 2017 May 2.

Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal.

Cardiovascular disease (CVD) is one of the leading causes of death worldwide which is more prevalent in women after menopause. Hormonal changes associated with menopause are accountable for dyslipidemic pattern that causes CVD and associated complications. Therefore, the present study was commenced to compare the lipid profile in pre- and postmenopausal women. Read More

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http://dx.doi.org/10.1155/2017/3824903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433412PMC
May 2017
30 Reads

Biochemical Content of Cambium of Eaten by Bears on the Far East of Russia.

Biochem Res Int 2017 26;2017:3020571. Epub 2017 Apr 26.

Pacific Geographical Institute FEB RAS, 7 Radio St., Vladivostok 690041, Russia.

The peculiarity of bears behavior of stripping of bark is typical for all species. We have described the damage to trees, by Asiatic black bear and brown bear in Primorsky Krai and by brown bears on the Sakhalin Island during 1998-2015. In this study, we studied the damaged bark of the tree only in cases where it was clear that part of the cambium was eaten by bears. Read More

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http://dx.doi.org/10.1155/2017/3020571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424178PMC
April 2017
2 Reads

Salivary Distinctiveness and Modifications in Males with Diabetes and Behçet's Disease.

Biochem Res Int 2017 21;2017:9596202. Epub 2017 Feb 21.

Department of Oral Medicine, Faculty of Dentistry, University of Damascus, Damascus, Syria.

Oral diseases associated with systematic diseases as metabolic and vasculitic have been included in this paper. This will enhance our understanding of the salivary function in promoting healthy oral condition. The study investigates the effects of type I and type II diabetes mellitus in well-controlled diabetic patients, in addition to on saliva flow rate (SFR), pH, the decay, missing, and filled tooth (DMFT) index, glucose, and major earth-alkaline ions (Ca and Mg) compared to healthy males and age-matched controls. Read More

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http://dx.doi.org/10.1155/2017/9596202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339495PMC
February 2017
180 Reads

Protective Effect of Edaravone against Carbon Monoxide Induced Apoptosis in Rat Primary Cultured Astrocytes.

Biochem Res Int 2017 2;2017:5839762. Epub 2017 Feb 2.

Department of Rehabilitation Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China.

. To observe the protective effect of edaravone (Eda) on astrocytes after prolonged exposure to carbon monoxide (CO) and further to investigate the potential mechanisms of Eda against CO-induced apoptosis. . Read More

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http://dx.doi.org/10.1155/2017/5839762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312051PMC
February 2017
6 Reads

In Vitro and In Vivo Effects of Norathyriol and Mangiferin on -Glucosidase.

Biochem Res Int 2017 10;2017:1206015. Epub 2017 Jan 10.

Institute of Drug Discovery & Development, Kunming Pharmaceutical Corporation, Kunming 650106, China.

Norathyriol is a metabolite of mangiferin. Mangiferin has been reported to inhibit -glucosidase. To the best of our knowledge, no study has been conducted to determine or compare those two compounds on inhibiting -glucosidase in vitro and in vivo by far. Read More

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https://www.hindawi.com/journals/bri/2017/1206015/
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http://dx.doi.org/10.1155/2017/1206015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259675PMC
January 2017
2 Reads

Molecular Evolution of the Glycosyltransferase 6 Gene Family in Primates.

Biochem Res Int 2016 4;2016:9051727. Epub 2016 Dec 4.

Laboratório de Biologia Molecular "Francisco Mauro Salzano", Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.

Glycosyltransferase 6 gene family includes ABO, Ggta1, iGb3S, and GBGT1 genes and by three putative genes restricted to mammals, GT6m6, GTm6, and GT6m7, only the latter is found in primates. GT6 genes may encode functional and nonfunctional proteins. Ggta1 and GBGT1 genes, for instance, are pseudogenes in catarrhine primates, while iGb3S gene is only inactive in human, bonobo, and chimpanzee. Read More

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http://dx.doi.org/10.1155/2016/9051727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164903PMC
December 2016
7 Reads

Crystal Structures of Two Isozymes of Citrate Synthase from Sulfolobus tokodaii Strain 7.

Biochem Res Int 2016 30;2016:7560919. Epub 2016 Aug 30.

Department of Physics, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.

Thermoacidophilic archaeon Sulfolobus tokodaii strain 7 has two citrate synthase genes (ST1805-CS and ST0587-CS) in the genome with 45% sequence identity. Because they exhibit similar optimal temperatures of catalytic activity and thermal inactivation profiles, we performed structural comparisons between these isozymes to elucidate adaptation mechanisms to high temperatures in thermophilic CSs. The crystal structures of ST1805-CS and ST0587-CS were determined at 2. Read More

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http://dx.doi.org/10.1155/2016/7560919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021468PMC
September 2016
2 Reads

Presynaptic Proteins as Markers of the Neurotoxic Activity of BmjeTX-I and BmjeTX-II Toxins from Bothrops marajoensis (Marajó Lancehead) Snake Venom.

Biochem Res Int 2016 18;2016:2053459. Epub 2016 Aug 18.

Multidisciplinary Research Laboratory, São Francisco University (USF), Avenida São Francisco de Assis 218, Jardim São José, 12916-350 Bragança Paulista, SP, Brazil; Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, Cidade Universitária Zeferino Vaz, 13083-365 Campinas, SP, Brazil.

Neuromuscular preparations exposed to B. marajoensis venom show increases in the frequency of miniature end-plate potentials and twitch tension facilitation followed by presynaptic neuromuscular paralysis, without evidences of muscle damage. Considering that presynaptic toxins interfere into the machinery involved in neurotransmitter release (synaptophysin, synaptobrevin, and SNAP25 proteins), the main objective of this communication is to analyze, by immunofluorescence and western blotting, the expression of the synaptic proteins, synaptophysin, synaptobrevin, and SNAP25 and by myography, light, and transmission electron microscopy the pathology of motor nerve terminals and skeletal muscle fibres of chick biventer cervicis preparations (CBC) exposed in vitro to BmjeTX-I and BmjeTX-II toxins from B. Read More

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http://dx.doi.org/10.1155/2016/2053459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007310PMC
September 2016
12 Reads

Urinary Markers of Tubular Injury in HIV-Infected Patients.

Biochem Res Int 2016 17;2016:1501785. Epub 2016 Jul 17.

Department of Clinical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Renal disease is a common complication of HIV-infected patients, associated with increased risk of cardiovascular events, progression to AIDS, AIDS-defining illness, and mortality. Early and accurate identification of renal disease is therefore crucial to improve patient outcomes. The use of serum creatinine, along with proteinuria, to detect renal involvement is essentially to screen for markers of glomerular disease and may not be effective in detecting earlier stages of renal injury. Read More

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http://dx.doi.org/10.1155/2016/1501785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967446PMC
August 2016
1 Read
1 Citation

A Bioinformatics Analysis Reveals a Group of MocR Bacterial Transcriptional Regulators Linked to a Family of Genes Coding for Membrane Proteins.

Biochem Res Int 2016 30;2016:4360285. Epub 2016 Jun 30.

Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, 00185 Roma, Italy.

The MocR bacterial transcriptional regulators are characterized by an N-terminal domain, 60 residues long on average, possessing the winged-helix-turn-helix (wHTH) architecture responsible for DNA recognition and binding, linked to a large C-terminal domain (350 residues on average) that is homologous to fold type-I pyridoxal 5'-phosphate (PLP) dependent enzymes like aspartate aminotransferase (AAT). These regulators are involved in the expression of genes taking part in several metabolic pathways directly or indirectly connected to PLP chemistry, many of which are still uncharacterized. A bioinformatics analysis is here reported that studied the features of a distinct group of MocR regulators predicted to be functionally linked to a family of homologous genes coding for integral membrane proteins of unknown function. Read More

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http://dx.doi.org/10.1155/2016/4360285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944035PMC
July 2016
3 Reads

Potential Properties of Plant Sprout Extracts on Amyloid β.

Biochem Res Int 2016 27;2016:9347468. Epub 2016 Jun 27.

Laboratory on Ageing & Health Management, Graduate School of Nursing & Health, Aichi Prefectural University, Tohgoku, Kamishidami, Moriyama, Nagoya 463-8502, Japan.

The aim of this study is to examine the amyloid β (Aβ) inhibition mechanism of plant sprouts' aqueous extracts (PSAE). In this study, we screened the effects of five plant sprouts' extracts on Aβ (1-42) structure modification using gel electrophoresis. In PSAE, no band of Aβ monomer was recognized in Japanese butterbur. Read More

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http://dx.doi.org/10.1155/2016/9347468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939385PMC
July 2016
1 Read

Cetuximab and Cisplatin Show Different Combination Effect in Nasopharyngeal Carcinoma Cells Lines via Inactivation of EGFR/AKT Signaling Pathway.

Biochem Res Int 2016 24;2016:7016907. Epub 2016 May 24.

The Fourth Clinical School of Nanjing Medical University, Nanjing 210009, China; Department of Radiation Oncology, Nanjing Medical University Affiliated Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, China; Xuzhou Medical College, Xuzhou 210009, China.

Nasopharyngeal carcinoma (NPC) is a common malignant cancer in South China. Cisplatin is a classical chemotherapeutic employed for NPC treatment. Despite the use of cisplatin-based concurrent chemoradiotherapy, distant failure still confuses clinicians and the outcome of metastatic NPC remains disappointing. Read More

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http://downloads.hindawi.com/journals/bri/2016/7016907.pdf
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http://www.hindawi.com/journals/bri/2016/7016907/
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http://dx.doi.org/10.1155/2016/7016907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894995PMC
June 2016
3 Reads

Production of Laccase by Cochliobolus sp. Isolated from Plastic Dumped Soils and Their Ability to Degrade Low Molecular Weight PVC.

Biochem Res Int 2016 12;2016:9519527. Epub 2016 May 12.

Department of Virology and DST-PURSE Centre, Sri Venkateswara University, Tirupati 517502, India.

One of the utmost man-made problems faced today has been the ever-increasing plastic waste filling the world. It accounts for an estimated 20-30% (by volume) of municipal solid waste in landfill sites worldwide. Research on plastic biodegradation has been steadily growing over the past four decades. Read More

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http://dx.doi.org/10.1155/2016/9519527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880699PMC
June 2016
1 Citation

Perspective of Fe3O4 Nanoparticles Role in Biomedical Applications.

Biochem Res Int 2016 12;2016:7840161. Epub 2016 May 12.

Biotechnology Research Center and Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 917751365, Iran.

In recent years, although many review articles have been presented about bioapplications of magnetic nanoparticles by some research groups with different expertise such as chemistry, biology, medicine, pharmacology, and materials science and engineering, the majority of these reviews are insufficiently comprehensive in all related topics like magnetic aspects of process. In the current review, it is attempted to carry out the inclusive surveys on importance of magnetic nanoparticles and especially magnetite ones and their required conditions for appropriate performance in bioapplications. The main attentions of this paper are focused on magnetic features which are less considered. Read More

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http://dx.doi.org/10.1155/2016/7840161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884576PMC
June 2016
7 Reads

Para-Phenylenediamine Induces Apoptotic Death of Melanoma Cells and Reduces Melanoma Tumour Growth in Mice.

Biochem Res Int 2016 17;2016:3137010. Epub 2016 May 17.

Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700 019, India.

Melanoma is one of the most aggressive forms of cancer, usually resistant to standard chemotherapeutics. Despite a huge number of clinical trials, any success to find a chemotherapeutic agent that can effectively destroy melanoma is yet to be achieved. Para-phenylenediamine (p-PD) in the hair dyes is reported to purely serve as an external dyeing agent. Read More

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http://dx.doi.org/10.1155/2016/3137010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886052PMC
June 2016
32 Reads

Effect of pH, Temperature, and Chemicals on the Endoglucanases and β-Glucosidases from the Thermophilic Fungus Myceliophthora heterothallica F.2.1.4. Obtained by Solid-State and Submerged Cultivation.

Biochem Res Int 2016 8;2016:9781216. Epub 2016 May 8.

Laboratório de Bioquímica de Proteínas, Departamento de Química e Ciências Ambientais, Universidade Estadual Paulista (UNESP), Rua Cristovão Colombo 2265, 15054-000 São José do Rio Preto, SP, Brazil.

This work reports endoglucanase and beta-glucosidase production by the thermophilic fungus Myceliophthora heterothallica in solid-state (SSC) and submerged (SmC) cultivation. Wheat bran and sugarcane bagasse were used for SSC and cardboard for SmC. Highest endoglucanase production in SSC occurred after 192 hours: 1,170. Read More

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http://dx.doi.org/10.1155/2016/9781216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875970PMC
May 2016
2 Reads

Phytochemical Evaluation of Moth Bean (Vigna aconitifolia L.) Seeds and Their Divergence.

Biochem Res Int 2016 30;2016:3136043. Epub 2016 Apr 30.

School of Studies in Biotechnology, Jiwaji University, Gwalior 474011, India.

In the present study, phytochemical contents of 25 moth bean (Vigna aconitifolia) seed accessions were evaluated. This includes protease inhibitors, phytic acid, radical scavenging activity, and tannins. The studies revealed significant variation in the contents of theses phytochemicals. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867057PMC
May 2016
4 Reads

Curcumin Mediated Attenuation of Carbofuran Induced Oxidative Stress in Rat Brain.

Biochem Res Int 2016 24;2016:7637931. Epub 2016 Apr 24.

Department of Biochemistry, University of Allahabad, Allahabad 211002, India.

The indiscriminate use of carbofuran to improve crop productivity causes adverse effects in nontargets including mammalian systems. The objective of this study was to evaluate carbofuran induced oxidative stress in rat brain stem and its attenuation by curcumin, a herbal product. Out of 6 groups of rats, 2 groups received two different doses of carbofuran, that is, 15 and 30% of LD50, respectively, for 30 days. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860210PMC
May 2016
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Purification and Characterization of a Novel Intracellular Sucrase Enzyme of Leishmania donovani Promastigotes.

Biochem Res Int 2016 14;2016:7108261. Epub 2016 Apr 14.

Division of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata, West Bengal 700032, India.

The promastigote stage of Leishmania resides in the sand fly gut, enriched with sugar molecules. Recently we reported that Leishmania donovani possesses a sucrose uptake system and a stable pool of intracellular sucrose metabolizing enzyme. In the present study, we purified the intracellular sucrase nearly to its homogeneity and compared it with the purified extracellular sucrase. Read More

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http://dx.doi.org/10.1155/2016/7108261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848734PMC
May 2016
4 Reads

Characterization of Seed Storage Proteins from Chickpea Using 2D Electrophoresis Coupled with Mass Spectrometry.

Biochem Res Int 2016 10;2016:1049462. Epub 2016 Apr 10.

School of Studies in Biotechnology, Jiwaji University, Gwalior 474011, India.

Proteomic analysis was employed to map the seed storage protein network in landrace and cultivated chickpea accessions. Protein extracts were separated by two-dimensional gel electrophoresis (2D-GE) across a broad range 3.0-10. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842031PMC
May 2016
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Potential Antioxidant Activity of New Tetracyclic and Pentacyclic Nonlinear Phenothiazine Derivatives.

Biochem Res Int 2016 4;2016:9896575. Epub 2016 Apr 4.

Biochemistry, Chemical Sciences Department, Godfrey Okoye University, PMB 01014, Thinkers Corner, Enugu, Nigeria.

The global increase in oxidative stress related diseases such as cancer, cardiovascular, and inflammatory diseases caused by overwhelming level of free radicals in the body has encouraged the search for new antioxidant agents. Based on the ability of newly synthesized phenothiazine derivatives (6-chloro-11-azabenzo[a]phenothiazine-5-one and 6-[4-bromophenyl]-10-methyl-11-azabenzo[a]phenothiazine-5-one) to oxidize H2O2, a known free radical to sulfoxide, this study assessed the in vitro and in vivo antioxidant activity. The synthesized phenothiazine derivatives exhibited reducing power potential to convert Fe(3+) to Fe(2+) and high ability to scavenge H2O2 free radical in vitro. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834405PMC
April 2016
9 Reads

Geometric Simulation Approach for Grading and Assessing the Thermostability of CALBs.

Biochem Res Int 2016 31;2016:4101059. Epub 2016 Mar 31.

Computational Biology Lab, Department of Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India.

Candida antarctica lipase B (CALB) is a known stable and highly active enzyme used widely in biodiesel synthesis. In this work, the stability of native (4K6G) and mutant (4K5Q) CALB was studied through various structural parameters using conformational sampling approach. The contours of polar surface area and surface area of mutant CALB were 11357. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830698PMC

From Synthesis to Biological Impact of Pd (II) Complexes: Synthesis, Characterization, and Antimicrobial and Scavenging Activity.

Biochem Res Int 2016 16;2016:4359375. Epub 2016 Mar 16.

School of Chemical Sciences, Central University of Gujarat, Gandhinagar 382030, India.

The Pd (II) complexes with a series of halosubstituted benzylamine ligands (BLs) have been synthesized and characterized with different spectroscopic technique such as FTIR, UV/Vis, LCMS, (1)H, and (13)C NMR. Their molecular sustainability in different solvents such as DMSO, DMSO : H2O, and DMSO : PBS at physiological condition (pH 7.2) was determined by UV/Vis spectrophotometer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812500PMC

Nationality, Gender, Age, and Body Mass Index Influences on Vitamin D Concentration among Elderly Patients and Young Iraqi and Jordanian in Jordan.

Biochem Res Int 2016 24;2016:8920503. Epub 2016 Mar 24.

Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 00962, Jordan.

Vitamin D is necessary for maintaining and regulating calcium levels; thus, insufficiency of vitamin D increases the risk of many chronic diseases. This study aimed to examine vitamin D levels among Jordanian and Iraqi volunteers and find the relation between vitamin D level and lipid profile patients. Vitamin D levels were evaluated using enzyme-linked immunosorbent assay. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823503PMC
April 2016
22 Reads
3 Citations

Oxidative Stress: An Effective Prognostic Tool for an Early Detection of Cardiovascular Disease in Menopausal Women.

Biochem Res Int 2016 16;2016:6157605. Epub 2016 Mar 16.

Department of Medicine, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.

Background. Menopause, a form of reproductive aging, is marked by many hormonal variations which cause imbalance in the oxidative processes resulting in onset of endothelial dysfunction leading to cardiovascular disease (CVD). We aimed to analyze the effect of oxidative stress in an early detection of CVD in all menopausal women both normolipidemic and hyperlipidemic. Read More

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http://dx.doi.org/10.1155/2016/6157605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812210PMC
April 2016
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Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic Exercise.

Biochem Res Int 2016 15;2016:3757623. Epub 2016 Mar 15.

Department of Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran; Cellular & Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Objective. To assess the influence of different physical training status on exercise-induced oxidative stress and changes in cellular redox state. Methods. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811060PMC

In Silico Screening, Alanine Mutation, and DFT Approaches for Identification of NS2B/NS3 Protease Inhibitors.

Biochem Res Int 2016 25;2016:7264080. Epub 2016 Feb 25.

King Institute of Preventive Medicine, Guindy, Chennai, India.

To identify the ligand that binds to a target protein with high affinity is a nontrivial task in computer-assisted approaches. Antiviral drugs have been identified for NS2B/NS3 protease enzyme on the mechanism to cleave the viral protein using the computational tools. The consequence of the molecular docking, free energy calculations, and simulation protocols explores the better ligand. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785246PMC

Changes in Lipid Profiles of HIV(+) Adults over Nine Months at a Harare HIV Clinic: A Longitudinal Study.

Biochem Res Int 2016 8;2016:3204818. Epub 2016 Mar 8.

Institute of Clinical Medicine, University in Oslo, Oslo University Hospital, P.O. Box 1171, Blindern, 0318 Oslo, Norway.

HIV infection, together with ART, is associated with changes in biochemical, metabolic parameters and lipid profiles. The aim of this study was to compare changes in lipid profiles among HIV positive outpatients over nine months. 171 patients were investigated, 79% were ART experienced, and 82% of ART experienced patients were on NVP/EFV first line at baseline, but some patients changed ART groups over follow-up and classification was based on intent to treat. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802011PMC
April 2016
8 Reads

The Ginkgo biloba Extract Reverses the Renal Effects of Titanium Dioxide Nanoparticles in Adult Male Rats.

Biochem Res Int 2016 3;2016:5781579. Epub 2016 Mar 3.

Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, 20131 Aguascalientes, AGS, Mexico.

The Ginkgo biloba extract (GbE) is a commercial product used as a nutraceutic herbal remedy in Europe and US. It contains 27% of the polyphenols isorhamnetin, kaempferol, and quercetin, as antioxidants. We used male adult Wistar rats (200-300 g), divided into four groups: control group (treated with 5. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794584PMC
April 2016
3 Reads

Biosensors in Health Care: The Milestones Achieved in Their Development towards Lab-on-Chip-Analysis.

Biochem Res Int 2016 3;2016:3130469. Epub 2016 Mar 3.

Department of Biochemistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh 492099, India.

Immense potentiality of biosensors in medical diagnostics has driven scientists in evolution of biosensor technologies and innovating newer tools in time. The cornerstone of the popularity of biosensors in sensing wide range of biomolecules in medical diagnostics is due to their simplicity in operation, higher sensitivity, ability to perform multiplex analysis, and capability to be integrated with different function by the same chip. There remains a huge challenge to meet the demands of performance and yield to its simplicity and affordability. Read More

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http://dx.doi.org/10.1155/2016/3130469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794574PMC
April 2016
5 Reads

Influenza A Virus and Influenza B Virus Can Induce Apoptosis via Intrinsic or Extrinsic Pathways and Also via NF-κB in a Time and Dose Dependent Manner.

Biochem Res Int 2016 2;2016:1738237. Epub 2016 Mar 2.

Central Public Health Laboratories (CPHL), Cairo 11613, Egypt.

Influenza viruses are able to cause annual epidemics and pandemics due to their mutation rates and reassortment capabilities leading to antigenic shifts and drifts. To identify host response to influenza A and B viruses on A549 and MDCK II cells at low and high MOIs, expressions of MxA and caspases 3, 8, and 9 and BAD, TNFα, and IκBα genes were measured in the cells supernatants. H1N1 and H3N2 prefer to initially enhance the intrinsic pathway, determined by higher caspase 9 activity in MDCK II cells compared to caspase 8 activity and vice versa in A549 cells at different MOIs, while INF B prefers extrinsic pathway in A549 cells according to significant low or undetectable caspase 9 activity and high activity of caspase 8 but also can induce intrinsic pathway in MDCK II cells as determined by significant low or undetectable activity of caspase 8 and high caspase 9 activity at different MOIs; the considerable MxA expression was found in influenza A and B viruses infected A549 and MDCK II cells at low MOIs. Read More

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http://dx.doi.org/10.1155/2016/1738237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793101PMC
April 2016
8 Reads

HPV Infection and Prognostic Factors of Tongue Squamous Cell Carcinoma in Different Ethnic Groups from Geographically Closed Cohort in Xinjiang, China.

Biochem Res Int 2016 10;2016:7498706. Epub 2016 Mar 10.

The Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, 79 Qinchun Road, Hangzhou, Zhejiang 310003, China; Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases, 79 Qinchun Road, Hangzhou, Zhejiang 310003, China.

Background. The effect of HPV infection status and ethnic differences on the prognosis of tongue squamous cell carcinoma in Xinjiang presents an interesting set of conditions that has yet to be studied. Methods. Read More

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http://dx.doi.org/10.1155/2016/7498706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806271PMC
April 2016
4 Reads

Characterization of Jamaican Delonix regia and Cassia fistula Seed Extracts.

Biochem Res Int 2016 10;2016:3850102. Epub 2016 Mar 10.

Department of Chemistry, The University of the West Indies, Mona, Kingston 7, Jamaica.

Delonix regia and Cassia fistula seed extracts were evaluated for their antioxidant activity, total phenolics, ash, zinc and fatty acid content. Fourier Transform Infrared Spectroscopy (FTIR) was utilized to assess the chemical functionalities present within the seeds. Antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Trolox equivalent antioxidant capacity (TEAC) assays. Read More

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http://www.hindawi.com/journals/bri/2016/3850102/
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http://dx.doi.org/10.1155/2016/3850102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806270PMC
April 2016
6 Reads