3,281 results match your criteria Biochemical genetics[Journal]


Association of the IL6 Gene Polymorphism with Component Features of Metabolic Syndrome in Obese Subjects.

Biochem Genet 2019 Apr 15. Epub 2019 Apr 15.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, 99199-91766, Mashhad, Iran.

Metabolic syndrome (MetS) is a risk factor for type 2 diabetes mellitus and cardiovascular disease. Obesity is a component of the metabolic syndrome. Several genetic variants are reported to be associated with obesity and hypo adiponectinemia, including ars1800796 polymorphism of the interleukin-6 (IL-6) gene. Read More

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http://dx.doi.org/10.1007/s10528-019-09913-5DOI Listing

Combination of Simple Sequence Repeat, S-Locus Polymorphism and Phenotypic Data for Identification of Tunisian Plum Species (Prunus spp.).

Biochem Genet 2019 Apr 12. Epub 2019 Apr 12.

Laboratory of Molecular Genetics, Immunology & Biotechnology LR99ES12, Faculty of Sciences of Tunis, University of Tunis El Manar, Campus University, El Manar, 2092, Tunis, Tunisia.

Plums (Prunus spp.) are among the first fruit tree species that attracted human interest. Artificial crosses between wild and domesticated species of plums are still paving the way for creation of new phenotypic variability. Read More

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http://dx.doi.org/10.1007/s10528-019-09922-4DOI Listing

Discovery and Utilization of EST-SSR Marker Resource for Genetic Diversity and Population Structure Analyses of a Subtropical Bamboo, Dendrocalamus hamiltonii.

Biochem Genet 2019 Apr 5. Epub 2019 Apr 5.

Molecular Genetics & Genomics Lab, Department of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India.

Dendrocalamus hamiltonii is a giant bamboo species native to Indian subcontinent with high economic importance. Nevertheless, highly outcross nature and flowering once in decades impose severe limitation in its propagation. Identification and mixed cultivation of genetically diverse genotypes may assist successful breeding and natural recombination of desirable traits. Read More

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http://dx.doi.org/10.1007/s10528-019-09914-4DOI Listing

IGF2 is Deregulated During the Development of Uterine Cervical Carcinoma in Indian Patients.

Biochem Genet 2019 Apr 4. Epub 2019 Apr 4.

Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, 700 026, India.

Uterine cervical carcinoma (CACX) is one of the leading causes of deaths in Indian women. Chromosomal alterations including 11p15.5 locus were reported in CACX. Read More

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http://dx.doi.org/10.1007/s10528-019-09917-1DOI Listing
April 2019
2 Reads

Association of rs146292819 Polymorphism in ABCA1 Gene with the Risk of Coronary Artery Disease in Pakistani Population.

Biochem Genet 2019 Apr 3. Epub 2019 Apr 3.

Department of Zoology, University of Education, Lower Mall Campus, Lahore, Pakistan.

Coronary artery disease (CAD) is an inflammatory heart disease characterized by the narrowing of coronary arteries. ATP-binding cassette transporter A1 (ABCA1) is a gene involved in regulation of cholesterol efflux and formation of high-density lipoprotein cholesterol (HDL-C). Present study aimed to explore the association of ABCA1 rs146292819 polymorphism with CAD development as well as its effect on serum lipid levels in the Pakistani population. Read More

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http://dx.doi.org/10.1007/s10528-019-09915-3DOI Listing
April 2019
1 Read

De Novo Assembled Transcriptome Analysis and Identification of Genic SSR Markers in Red-Flowered Strawberry.

Biochem Genet 2019 Mar 1. Epub 2019 Mar 1.

College of Horticulture, Shenyang Agricultural University, Shenyang, 110866, China.

Red-flowered strawberry is a new ornamental flower derived from intergeneric hybridization (Fragaria × Potentilla). To date, few molecular markers have been reported for this plant. RNA sequencing provides a relatively fast and low-cost approach for large-scale detection of simple sequence repeats (SSRs). Read More

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http://dx.doi.org/10.1007/s10528-019-09912-6DOI Listing

Genetic Polymorphisms of CCDC26 rs891835, rs6470745, and rs55705857 in Glioma Risk: A Systematic Review and Meta-analysis.

Biochem Genet 2019 Feb 18. Epub 2019 Feb 18.

Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, Mexico.

A genetic component is accepted in the etiology of the glioma. Evidence from candidate genes studies and GWAS reveal that CCDC26 gene could increase the risk of glioma. We performed a systematic review and up-to-date meta-analysis to explore if polymorphisms of CCDC26 gene (rs891835, rs6470745, and rs55705857) may be a susceptibility factor in developing glioma. Read More

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http://dx.doi.org/10.1007/s10528-019-09911-7DOI Listing
February 2019

Variant Ionotropic Receptors are Expressed in the Antennae of Anopheles sinensis (Diptera: Culicidae).

Biochem Genet 2019 Feb 8. Epub 2019 Feb 8.

Department of Chemistry and Biology, National University of Defense Technology, No. 109 Deya Road, Kaifu District, Changsha, Hunan, China.

Mosquitoes transmit many harmful diseases that seriously threaten public health. The mosquito's olfactory system is of great significance for host selection. Inotropic receptors (IRs) and olfactory receptors (ORs) have been demonstrated to be capable of odorant molecular recognition. Read More

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http://dx.doi.org/10.1007/s10528-019-09910-8DOI Listing
February 2019
1 Read

Analysis of Genetic Diversity and Development of a SCAR Marker for Green Tea (Camellia sinensis) Cultivars in Zhejiang Province: The Most Famous Green Tea-Producing Area in China.

Biochem Genet 2019 Feb 8. Epub 2019 Feb 8.

National Center for Tea Improvement, Tea Research Institute of the Chinese Academy of Agricultural Sciences/ Key Laboratory of Tea Biology and Resources Utilization, Ministry of Agriculture, 9 South Meiling Road, Hangzhou, 310008, China.

Camellia sinensis (L.) O. Kuntze is one of the most important non-alcoholic beverage crops in Asian and African countries. Read More

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http://dx.doi.org/10.1007/s10528-019-09909-1DOI Listing
February 2019
1 Read

Population Genetics of Calotropis gigantea, a Medicinal and Fiber Resource Plant, as Inferred from Microsatellite Marker Variation in two Native Countries.

Biochem Genet 2019 Feb 7. Epub 2019 Feb 7.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China.

Calotropis gigantea is well known for its aesthetic, medicinal, pharmacological, fodder, fuel, and fiber production potential. Unfortunately, this plant species is still undomesticated, and the genetic information available for crop improvement is limited. For this study, we sampled 21 natural populations of C. Read More

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http://dx.doi.org/10.1007/s10528-019-09904-6DOI Listing
February 2019

Down-Regulation of SIRT1 Expression by mir-23b Contributes to Lipid Accumulation in HepG2 Cells.

Biochem Genet 2019 Jan 29. Epub 2019 Jan 29.

Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran.

Non-alcoholic fatty liver disease is one of the main causes of chronic liver disease and therefore is currently considered a major public health problem. Sirtuin 1 (SIRT1) is an NAD-dependent deacetylase enzyme that contributes in the regulation of metabolic processes and protects against lipid accumulation in hepatocytes. Its expression is potentially regulated by microRNAs which attach to the 3' untranslated region (3'-UTR) of their target mRNA. Read More

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http://dx.doi.org/10.1007/s10528-019-09905-5DOI Listing
January 2019
1 Read

A Novel CNGA1 Gene Mutation (c.G622A) of Autosomal Recessive Retinitis Pigmentosa Leads to the CNGA1 Protein Reduction on Membrane.

Biochem Genet 2019 Jan 16. Epub 2019 Jan 16.

Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.

CNGA1 encodes a membrane protein on rod photoreceptor related to phototransduction. The present study was to identify a novel mutation of CNGA1 associated with autosomal recessive retinitis pigmentosa by using next generation sequencing of a Chinese family. Next generation sequencing and Sanger sequencing has identified a compound heterozygous mutation in CNGA1 gene, c0. Read More

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http://dx.doi.org/10.1007/s10528-019-09907-3DOI Listing
January 2019

Genome-Wide Identification and Characterization of DIR Genes in Medicago truncatula.

Biochem Genet 2019 Jan 16. Epub 2019 Jan 16.

College of Life Science, Qufu Normal University, Qufu, 273165, People's Republic of China.

Dirigent proteins (DIRs) are critically involved in the formation of lignans, a diverse and widely distributed class of secondary plant metabolites exhibiting interesting pharmacological activities and implicated in natural plant defense. However, no detailed information is available about DIR gene family in Medicago truncatula. In this study, a total of 45 DIR genes were identified in M. Read More

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http://dx.doi.org/10.1007/s10528-019-09903-7DOI Listing
January 2019
1 Read

Omega-3 PUFA Alters the Expression Level but Not the Methylation Pattern of the WIF1 Gene Promoter in a Pancreatic Cancer Cell Line (MIA PaCa-2).

Biochem Genet 2019 Jan 16. Epub 2019 Jan 16.

Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran.

Pancreatic cancer is the fourth leading cause of death in both males and females, with a 5-year relative survival rate of 8%. The Wnt signaling pathway has a significant role in the pathogenesis of many tumors, including those of pancreatic cancer. Hypermethylation of the Wnt inhibitory Factor-1 (WIF1) gene promoter have been detected in different types of cancer. Read More

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http://dx.doi.org/10.1007/s10528-018-9895-0DOI Listing
January 2019

Engineering Corynebacterium glutamicum Mutants for 3-Methyl-1-butanol Production.

Biochem Genet 2019 Jan 14. Epub 2019 Jan 14.

Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou, 510640, China.

3-Methyl-1-butanol (3MB) is a promising biofuel that can be produced from 2-ketoisocaproate via the common L-leucine biosynthesis pathway. Corynebacterium glutamicum was chosen as a host bacterium because of its strong resistance to isobutanol. In the current study, several strategies were designed to overproduce 3MB in C. Read More

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http://dx.doi.org/10.1007/s10528-019-09906-4DOI Listing
January 2019

PTPN22 +788 G>A (R263Q) Polymorphism is Associated with mRNA Expression but it is not a Susceptibility Marker for Rheumatoid Arthritis Patients from Western Mexico.

Biochem Genet 2019 Jan 14. Epub 2019 Jan 14.

Research Institute in Biomedical Sciences, University Center of Health Science, University of Guadalajara, Guadalajara, Jalisco, Mexico.

PTPN22 represents an important non-HLA gene that has been strongly associated with rheumatoid arthritis (RA) pathogenesis. Several studies have reported a specific genetic variant for PTPN22 (+788 G>A; rs33996649) that might be associated with decreased RA risk in Caucasian population; nevertheless, its specific role in western Mexican population has not been yet described. A case-control study with 443 RA patients and 317 control subjects (CS) was conducted. Read More

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http://link.springer.com/10.1007/s10528-019-09902-8
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http://dx.doi.org/10.1007/s10528-019-09902-8DOI Listing
January 2019
8 Reads

Genetic Diversity and Population Structure in Upland Rice (Oryza sativa L.) of Mizoram, North East India as Revealed by Morphological, Biochemical and Molecular Markers.

Biochem Genet 2019 Jan 2. Epub 2019 Jan 2.

Department of Botany, Mizoram University, Aizawl, Mizoram, India.

Upland rice landraces from different villages of Mizoram, Northeast India were analyzed for seed morphology, amylose content, aromatic characteristic, seed storage protein profiling and genetic diversity. Results revealed variation in grain length, width, weight and shape. Protein profiling showed polypeptide bands ranging from 7 to 10 with similarity coefficient from 0. Read More

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http://dx.doi.org/10.1007/s10528-018-09901-1DOI Listing
January 2019

Identification and Characterization of a Novel Strigolactone-Insensitive Mutant, Dwarfism with High Tillering Ability 34 (dhta-34) in Rice (Oryza sativa L.).

Biochem Genet 2019 Jan 1. Epub 2019 Jan 1.

Department of Agronomy, Zhejiang University, Hangzhou, 310058, China.

Rice tillering ability and plant height are two of the important traits determining the grain yield. A novel rice (Oryza sativa L.) mutant dhta-34 from an Indica cultivar Zhenong 34 treated by ethyl methy1 sulfonate (EMS) was investigated in this study. Read More

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http://link.springer.com/10.1007/s10528-018-9896-z
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http://dx.doi.org/10.1007/s10528-018-9896-zDOI Listing
January 2019
4 Reads

Comparative Analysis of Expression Profiles of Reg Signaling Pathways-Related Genes Between AHF and HCC.

Biochem Genet 2019 Jan 1. Epub 2019 Jan 1.

College of Life Science, Henan Normal University, Xinxiang, 453007, Henan, China.

Regenerating islet-derived protein (Reg) could participate in the occurrence of diabetes mellitus, inflammation, tumors, and other diseased or damaged tissues. However, the correlation of Reg with acute hepatic failure (AHF) and hepatocellular carcinoma (HCC) is poorly defined. To reveal the expression profiles of Reg family and their possible regulatory roles in AHF and HCC, rat models of HCC and AHF were separately established, and Rat Genome 230 2. Read More

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http://dx.doi.org/10.1007/s10528-018-9900-7DOI Listing
January 2019
2 Reads

Evolution and Expression of S100A7 Gene in Vertebrates.

Biochem Genet 2018 Dec 15. Epub 2018 Dec 15.

College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.

The skin is the primary barrier between the internal organs of an organism and the environment, and it provides protection from ultraviolet (UV) radiation. According to the nocturnal bottleneck hypothesis, ungulates might have traversed to the grasslands and were exposed to UV radiation subsequent to the reduction in predation pressure. UV light exposure might have increased the S100A7 expression. Read More

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http://dx.doi.org/10.1007/s10528-018-9897-yDOI Listing
December 2018
4 Reads

Screening of Genetic Factor in the Interaction Between Periodontitis and Metabolic Traits Using Candidate Gene Association Study (CGAS).

Authors:
Kyung-Hui Moon

Biochem Genet 2018 Dec 13. Epub 2018 Dec 13.

Department of Dental Hygiene, Jinju Health College, Uibyeong-ro 51, Jinju, Korea.

Periodontitis has been reported to relate to metabolic syndrome traits such as obesity, blood pressure, and so on. However, the relation between periodontitis and metabolic syndrome remains unclear. The present study aimed to confirm common genetic factors between periodontitis and metabolic traits using Candidate gene association study (CGAS) in the Korean population. Read More

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http://dx.doi.org/10.1007/s10528-018-9899-9DOI Listing
December 2018

Association of SHMT1, MAZ, ERG, and L3MBTL3 Gene Polymorphisms with Susceptibility to Multiple Sclerosis.

Biochem Genet 2018 Nov 19. Epub 2018 Nov 19.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Multiple sclerosis (MS) is the most common inflammatory and chronic disease of the central nervous system (CNS). A complex interaction between genetic, environmental, and epigenetic factors is involved in the pathogenesis of MS. With the advancement of GWAS, various variants associated with MS have been identified. Read More

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http://dx.doi.org/10.1007/s10528-018-9894-1DOI Listing
November 2018
1 Read

Development of New SSR (Simple Sequence Repeat) Markers for Lentils (Lens culinaris Medik.) from Genomic Library Enriched with AG and AC Microsatellites.

Biochem Genet 2019 Apr 8;57(2):338-353. Epub 2018 Nov 8.

Department of Field Crops, Faculty of Agriculture, Harran University, Sanliurfa, 63300, Turkey.

Simple sequence repeat (SSR) markers are the major molecular tools for genetic and genomic researches that have been extensively developed and used in major crops. However, few are available for lentils (Lens culinaris M.), economically an important cool-season legume. Read More

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http://link.springer.com/10.1007/s10528-018-9893-2
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http://dx.doi.org/10.1007/s10528-018-9893-2DOI Listing
April 2019
14 Reads

Mitochondrial Genetic Diversity of the Freshwater Snail Melanoides tuberculata.

Biochem Genet 2019 Apr 26;57(2):323-337. Epub 2018 Oct 26.

Department of Biology, The Affiliated School of National Tainan First Senior High School, Tainan, 701, Taiwan.

According to geological history, Peninsular Malaysia and Borneo formed at different times and were once connected during Quaternary glaciations. To determine how this history has influenced phylogeography, our study examined the population genetic structure of the tropical freshwater gastropod Melanoides tuberculata across Peninsular Malaysia and Borneo using the sequences from mitochondrial DNA 16S rRNA and cytochrome oxidase subunit I genes (1168 bp). In total, 104 specimens were collected from seventeen populations. Read More

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http://dx.doi.org/10.1007/s10528-018-9892-3DOI Listing
April 2019
1 Read

Association Between SSR Molecular Markers and Chemical and Sensory Traits of Cacao Samples Using Multiple Regression Analysis.

Biochem Genet 2019 Apr 3;57(2):301-322. Epub 2018 Oct 3.

Instituto de Biociencias, Universidad Autónoma de Chiapas. Boulevard Príncipe Akishino sin número, Colonia Solidaridad 2000, C.P. 30798, Tapachula, Chiapas, Mexico.

The sensory properties of cacao beans are linked to the chemical composition of the seeds, and both characteristics are the partial results of its allelic composition. Therefore, it is useful to search for molecular markers associated with these traits. We perform multiple regression analysis to associate previously generated data of alleles generated with 12 SSR (of cultivated cacao trees) with data obtained from chemical and sensory characterization (of beans) of plants grown in the southern region from Mexico. Read More

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http://dx.doi.org/10.1007/s10528-018-9891-4DOI Listing
April 2019
2 Reads

Clinical and Demographic Evaluation According to MEFV Genes in Patients with Familial Mediterranean Fever.

Biochem Genet 2019 Apr 3;57(2):289-300. Epub 2018 Oct 3.

Department of Biostatistics, Gaziosmanpasa University School of Medicine, 60250, Tokat, Turkey.

The present study examined the relationship between clinical findings and mutation analyses in children with Familial Mediterranean Fever (FMF) in the inner Black Sea region of Turkey. This retrospective, cross-sectional study included patients with FMF who were evaluated between 2007 and 2015. FMF was diagnosed according to the Tel Hashomer criteria. Read More

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http://link.springer.com/10.1007/s10528-018-9889-y
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http://dx.doi.org/10.1007/s10528-018-9889-yDOI Listing
April 2019
2 Reads

Posttraumatic Stress Disorder Augments Plasma Triglycerides in TT Homozygotes of rs495225 at Growth Hormone Secretagogue Receptor Gene.

Biochem Genet 2019 Apr 29;57(2):273-288. Epub 2018 Sep 29.

Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, China.

Posttraumatic stress disorder (PTSD) and growth hormone secretagogue receptor (GHSR) were reported to be associated with plasma lipid and glucose levels. However, interplays of PTSD with GHSR on plasma lipid and glucose levels have not been explored yet. This study was to investigate the interplays of PTSD and GHSR rs495225 on plasma glucose and lipid profiles. Read More

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http://link.springer.com/10.1007/s10528-018-9890-5
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http://dx.doi.org/10.1007/s10528-018-9890-5DOI Listing
April 2019
18 Reads

Characterization of Cellulose Synthase A (CESA) Gene Family in Eudicots.

Biochem Genet 2019 Apr 28;57(2):248-272. Epub 2018 Sep 28.

Department of Biotechnology, Chonnam National University, Chonnam, 59626, Republic of Korea.

Cellulose synthase A (CESA) is a key enzyme involved in the complex process of plant cell wall biosynthesis, and it remains a productive subject for research. We employed systems biology approaches to explore structural diversity of eudicot CESAs by exon-intron organization, mode of duplication, synteny, and splice site analyses. Using a combined phylogenetics and comparative genomics approach coupled with co-expression networks we reconciled the evolution of cellulose synthase gene family in eudicots and found that the basic forms of CESA proteins are retained in angiosperms. Read More

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http://dx.doi.org/10.1007/s10528-018-9888-zDOI Listing
April 2019
27 Reads
0.865 Impact Factor

Retrovirus-Mediated Transfection of the Tissue-type Plasminogen Activator Gene Results in Increased Thrombolysis of Blood Clots.

Biochem Genet 2019 Apr 14;57(2):234-247. Epub 2018 Sep 14.

Department of Nephrology, Suzhou Municipal Hospital, Nanjing Medical University, No.242 Guangji Road, Suzhou, 215008, People's Republic of China.

Tissue-type plasminogen activator (tPA) is involved in the lysis of blood clots. In this study, we attempted to target thrombolysis and enhance blood clot lysis by generating a construct (pLEGFP-N1-tPA) to integrate tPA gene into the genome of different cell lines. pLEGFP-N1-tPA construct was generated and used to target the tPA gene in different cell lines. Read More

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http://dx.doi.org/10.1007/s10528-018-9887-0DOI Listing
April 2019
3 Reads

MIR146A rs2910164 (G/C) Polymorphism is Associated with Incidence of Preeclampsia in Gestational Diabetes Patients.

Biochem Genet 2019 Apr 18;57(2):222-233. Epub 2018 Aug 18.

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

Preeclampsia and gestational diabetes are common pregnancy disorders that may be interrelated. MIR146A rs2910164 (G/C) is a functional polymorphism that was associated with several diseases. This study aimed to investigate the frequency of rs2910164 polymorphism and its possible correlation with the incidence of preeclampsia in gestational diabetes patients. Read More

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http://dx.doi.org/10.1007/s10528-018-9886-1DOI Listing
April 2019
1 Read

Association Between GSTP1 Ile105Val Genetic Polymorphism and Dependency to Heroin and Opium.

Biochem Genet 2019 Apr 18;57(2):214-221. Epub 2018 Aug 18.

Department of Biology, College of Sciences, Shiraz University, Shiraz, 71467-13565, Iran.

Relationship between glutathione S-transferase P1 (GSTP1, OMIM: 134660) variants and the risk of drug dependency is unknown. Chronic use of illegal drugs leads to oxidative stress, which can be alleviated by cellular detoxification mechanisms. There are several polymorphisms in the GSTP1, including Ile105Val (rs1695). Read More

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http://dx.doi.org/10.1007/s10528-018-9885-2DOI Listing
April 2019
12 Reads

Morphometrics and Mitochondrial DNA Genes Analysis Suggest a New Species of Penaeus (Crustacea: Penaeidae) from the Persian Gulf.

Biochem Genet 2019 Apr 12;57(2):193-213. Epub 2018 Aug 12.

School of Biological Sciences, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia.

There are two morphotypes of Penaeus semisulcatus described hitherto in the Persian Gulf, namely the banded and non-banded antennae morphotypes. In this study, we used morphometric measurements and two mitochondrial genes (16S rRNA and cytochrome oxidase subunit I-COI) to assess relationships between the two morphotypes of P. semisulcatus. Read More

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http://dx.doi.org/10.1007/s10528-018-9884-3DOI Listing

Correction to: Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions.

Biochem Genet 2018 10;56(5):450

Fourth Affiliated Hospital, Anhui Medical University, Hefei, 230032, China.

The original version of this article unfortunately contained an error in the Acknowledgement section. The corrected text has been given below. Read More

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http://dx.doi.org/10.1007/s10528-018-9874-5DOI Listing
October 2018
12 Reads

Genetic Variation at 15 Autosomal STR Loci Among Seven Egyptian Populations.

Biochem Genet 2019 Feb 3;57(1):170-191. Epub 2018 Aug 3.

Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.

Egypt is a transcontinental country containing substantial ethnic, cultural, and linguistic diversity among its people. This study was conducted to investigate the genetic variation at 15 AmpFlSTR Identifiler short tandem repeat (STR) loci, D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA, within and between seven Egyptian populations. Samples of 814 unrelated individuals from Northern Coast, Delta, Greater Cairo, Canal governorates, Northern Upper Egypt, Southern Upper Egypt, and Sinai were investigated. Read More

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http://dx.doi.org/10.1007/s10528-018-9879-0DOI Listing
February 2019
6 Reads

TNIP1 Polymorphisms with the Risk of Hepatocellular Carcinoma Based on Chronic Hepatitis B Infection in Chinese Han Population.

Biochem Genet 2019 Feb 2;57(1):117-128. Epub 2018 Aug 2.

Department of Blood Transfusion, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, #157 Jinbi Road, Kunming, 650032, Yunnan, China.

Chronic hepatitis B virus (HBV) infection is an important etiology for the development of hepatocellular carcinoma (HCC). Tumor necrosis factor-α-induced protein 3-interacting protein 1 (TNIP1) is linked to specific inflammatory diseases as a novel type of endogenous inflammatory regulator. However, presently, rare information is found about the association between TNIP1 polymorphisms and HBV-induced HCC risk. Read More

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http://dx.doi.org/10.1007/s10528-018-9882-5DOI Listing
February 2019
3 Reads

Association of IL-8-251 A/T rs4073 and IL-10 rs1800872 -592C/A Polymorphisms and Coronary Artery Disease in North Indian Population.

Biochem Genet 2019 Feb 2;57(1):129-146. Epub 2018 Aug 2.

Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

CAD (Coronary Artery Disease) morbidity is becoming an endemic worldwide. Recently, the role of pro- and anti-inflammatory cytokines in the development of atherosclerotic plaques has been explored, but the association of their genetic polymorphisms and CAD has yet not been established. The present study aimed to investigate the association of IL-8-251A/T (rs4073) and IL-10 -592C/A (rs1800872) polymorphisms and the risk of CAD in North Indian population. Read More

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http://dx.doi.org/10.1007/s10528-018-9880-7DOI Listing
February 2019
1 Read
0.865 Impact Factor

Correlations of an Insertion/Deletion Polymorphism (rs10680577) in the RERT-lncRNA with the Susceptibility, Clinicopathological Features, and Prognosis of Lung Cancer.

Biochem Genet 2019 Feb 2;57(1):147-158. Epub 2018 Aug 2.

Department of Laboratory Medicine, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, 434020, Hubei, China.

The aim of this study was to investigate the correlations of an Ins/Del polymorphism (rs10680577) in the RERT-lncRNA with the susceptibility, clinicopathological features, and prognosis of lung cancer. A total of 376 patients with lung cancer and 419 healthy subjects were enrolled in this study. The genotype of rs10680577 was performed using polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis. Read More

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http://link.springer.com/10.1007/s10528-018-9883-4
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http://dx.doi.org/10.1007/s10528-018-9883-4DOI Listing
February 2019
9 Reads

Altered Expression of Zinc Transporter ZIP12 in Broilers of Ascites Syndrome Induced by Intravenous Cellulose Microparticle Injection.

Biochem Genet 2019 Feb 2;57(1):159-169. Epub 2018 Aug 2.

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, People's Republic of China.

Ascites syndrome (AS) is a harmful disease in fast-growing broilers characterized by heart failure and serious fluid accumulation in the abdominal cavity. One of the known functions of zinc transporter ZIP12 is an important regulator in pulmonary hypertension (PH) in rat. Whether chicken ZIP12 is involved in the process of AS need to be explored. Read More

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http://dx.doi.org/10.1007/s10528-018-9876-3DOI Listing
February 2019
2 Reads

Correction to: Functional Polymorphism Located in the microRNA Binding Site of the Insulin Receptor (INSR) Gene Confers Risk for Type 2 Diabetes Mellitus in the Bangladeshi Population.

Biochem Genet 2019 02;57(1):34

Laboratory of Population Genetics, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 1000, Bangladesh.

The original version of this article unfortunately contained a mistake in the co-author name. It should be Farhana Jahan instead of Farhan Jahan. Read More

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http://dx.doi.org/10.1007/s10528-018-9878-1DOI Listing
February 2019
16 Reads

Genetic Diversity and Molecular Characterization of Iranian Durum Wheat Landraces (Triticum turgidum durum (Desf.) Husn.) Using DArT Markers.

Biochem Genet 2019 Feb 26;57(1):98-116. Epub 2018 Jul 26.

Department of Plant Breeding, Yadegar-e-Imam Khomeini (RAH), Islamic Azad University, Shahre Rey Branch, Tehran, Iran.

Durum wheat is grown mainly in rain-fed regions of Iran and the Mediterranean district under stressful conditions. Different environmental conditions and agricultural practices among ancient communities have led to the development of locally adapted genotypes known as landraces. Landraces are a valued source of genetic variety and show definite adaptation to local environmental conditions according to their home of origin. Read More

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http://dx.doi.org/10.1007/s10528-018-9877-2DOI Listing
February 2019

Association of SELP Polymorphisms with Soluble P-Selectin Levels and Vascular Risk in Patients with Type 2 Diabetes Mellitus: A Case-Control Study.

Biochem Genet 2019 Feb 25;57(1):73-97. Epub 2018 Jul 25.

Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.

P-selectin, an adhesion molecule, is encoded by SELP and known as biomarker of endothelial as well as platelet dysfunction. SELP polymorphisms (rs6136, rs6127, and rs6125) and raised levels of soluble P-selectin (sP-selectin) have been associated with several disease conditions. The present study was aimed to determine the association of SELP variants and sP-selectin levels as well as vascular risk in Type 2 diabetes mellitus (T2DM) patients. Read More

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http://dx.doi.org/10.1007/s10528-018-9881-6DOI Listing
February 2019
8 Reads

ISSR Characterization and Quantification of Purpurin and Alizarin in Rubia cordifolia L. Populations from India.

Biochem Genet 2019 Feb 23;57(1):56-72. Epub 2018 Jul 23.

Department of Plant Biology and Systematics, CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Bangalore, Karnataka, 560065, India.

Rubia cordifolia L., is an industrially viable medicinal crop and is widely exploited for the therapeutic potential of its bioactive metabolite, purpurin. The present investigation aimed to explore the chemotypic and molecular variability in seven wild populations of R. Read More

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http://link.springer.com/10.1007/s10528-018-9875-4
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http://dx.doi.org/10.1007/s10528-018-9875-4DOI Listing
February 2019
10 Reads
0.865 Impact Factor

Bi-parentally Inherited Genetic Evidence for Male-Biased Dispersal in Common Moorhen (Gallinula chloropus).

Biochem Genet 2019 Feb 20;57(1):46-55. Epub 2018 Jul 20.

State Ministry of Education Key Laboratory of Poyang Lake Environment and Resource Utilization, School of Life Sciences, Nanchang University, Nanchang, 330031, People's Republic of China.

Dispersal is a life history trait that has relevant effect on both the dynamics and the genetics of species and sex-biased dispersal depends on how resource competition affects each of the sexes. In this study, a total of 210 blood samples including 121 Common Moorhen (Gallinula chloropus) females and 89 males were collected from 18 diverse areas during the breeding season. Based on 8 microsatellite markers analyses, we found that the most genetic diversities from female populations were higher than those from the males, where only 2 male individuals were identified as the long-distance dispersal. Read More

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http://dx.doi.org/10.1007/s10528-018-9873-6DOI Listing
February 2019
7 Reads

Gene Expression of ABHD6, a Key Factor in the Endocannabinoid System, Can Be Modulated by Female Hormones in Human Immune Cells.

Biochem Genet 2019 Feb 13;57(1):35-45. Epub 2018 Jul 13.

Department of Cell Biology, Embryology and Genetics, Centro de Ciências Biológicas (CCB), Federal University of Santa Catarina, Sala 301B, Florianópolis, 88040-900, Brazil.

One of the main risk factors for the development of an autoimmune disease is to be a woman. Much attention has been given to the involvement of female hormones in their etiology and sexual bias, although the mechanisms behind this potentially strong contribution in disease susceptibility are poorly understood. ABHD6 gene was recently identified as a risk factor for system lupus erythematosus and the risk was correlated with overexpression of the gene. Read More

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http://dx.doi.org/10.1007/s10528-018-9871-8DOI Listing
February 2019

Functional Polymorphism Located in the microRNA Binding Site of the Insulin Receptor (INSR) Gene Confers Risk for Type 2 Diabetes Mellitus in the Bangladeshi Population.

Biochem Genet 2019 Feb 4;57(1):20-33. Epub 2018 Jul 4.

Laboratory of Population Genetics, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 1000, Bangladesh.

Bangladesh has the second largest number of adults with diabetes in South Asia. Compelling evidence suggest that miRNAs contribute to the etiology of Type 2 diabetes mellitus (T2DM) by regulating many aspects of glucose homeostasis. Hence, we hypothesized that genetic polymorphisms in the diabetes-related miRNA target-binding sites could be associated with the risk of T2DM in Bangladesh. Read More

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http://dx.doi.org/10.1007/s10528-018-9872-7DOI Listing
February 2019
5 Reads
0.865 Impact Factor

Comparative Analysis of Regulatory Role of Notch Signaling Pathway in 8 Types Liver Cell During Liver Regeneration.

Biochem Genet 2019 Feb 30;57(1):1-19. Epub 2018 Jun 30.

College of Life Science, Henan Normal University, No. 46, Constrution East Road, Xinxiang, 453007, Henan, China.

Notch signaling is closely related to cell proliferation, cell apoptosis, cell fate decisions, DNA damage repair, and so on. However, the exactly regulatory mechanism of Notch signaling pathway in liver regeneration (LR) remains unclear. To reveal the role of Notch signaling pathway in rat liver regeneration, Ingenuity Pathway Analysis (IPA) software and related pathway database were firstly used to construct the Notch signaling pathway in this study. Read More

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http://dx.doi.org/10.1007/s10528-018-9869-2DOI Listing
February 2019
15 Reads

Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions.

Biochem Genet 2018 Oct 27;56(5):423-449. Epub 2018 Jun 27.

Fourth Affiliated Hospital, Anhui Medical University, Hefei, 230032, China.

In this review, we summarize the current understanding of microRNA (miRNA)-mediated modulation of the gene expression in the fatty liver as well as related signaling pathways. Because of the breadth and diversity of miRNAs, miRNAs may have a very wide variety of biological functions, and much evidence has confirmed that miRNAs are involved in the pathogenesis of fatty liver. In the pathophysiological mechanism of fatty liver, miRNAs may be regulated by upstream regulators, and have their own regulatory targets. Read More

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http://dx.doi.org/10.1007/s10528-018-9870-9DOI Listing
October 2018
3 Reads

Investigation of Chinese Wolfberry (Lycium spp.) Germplasm by Restriction Site-Associated DNA Sequencing (RAD-seq).

Biochem Genet 2018 Dec 6;56(6):575-585. Epub 2018 Jun 6.

Qinghai Academy of Agriculture and Forestry, Qinghai University, Xining, 810016, China.

Chinese wolfberry (Lycium spp.) is an important edible and medicinal plant, with a long cultivation history. The genetic relationships among wild Lycium species and landraces have been unclear for a number of reasons, which has hindered the breeding of modern Chinese wolfberry cultivars. Read More

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http://dx.doi.org/10.1007/s10528-018-9861-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223726PMC
December 2018
1 Read

Epigenetic Modifications Linked to T2D, the Heritability Gap, and Potential Therapeutic Targets.

Biochem Genet 2018 Dec 5;56(6):553-574. Epub 2018 Jun 5.

Department of Internal Medicine, University of Medicine and Pharmacy of Tîrgu Mureș, 38 Gheorghe Marinescu Street, 540139, Tîrgu Mureș, Romania.

With the pandemic of type 2 diabetes (T2D), there is an ever-increasing need to fully understand the underlying mechanisms of the disease. Type 2 diabetes shows a high heritability risk (25-80%); however, genes account only for 10% of this risk. From all the risk factors for diabetes, epigenetic mechanisms have the highest statistical scoring in explaining the disease. Read More

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http://dx.doi.org/10.1007/s10528-018-9863-8DOI Listing
December 2018
6 Reads

Detection of Insertions/Deletions Within SIRT1, SIRT2 and SIRT3 Genes and Their Associations with Body Measurement Traits in Cattle.

Biochem Genet 2018 Dec 4;56(6):663-676. Epub 2018 Jun 4.

Shaanxi Key Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, People's Republic of China.

Growth traits are complex quantitative traits controlled by numerous candidate genes, and they can be well-evaluated using body measurement traits. As the members of the nicotinamide adenine dinucleotide-dependent family of histone deacetylases, class I sirtuin genes (including SIRT1, SIRT2 and SIRT3) play crucial roles in regulating lipid metabolism, cellular growth and metabolism, suggesting that they are potential candidate genes affecting body measurement traits in animals. Hence, the objective of this work aimed to detect novel insertions/deletions (indels) of SIRT1, SIRT2 and SIRT3 genes in 955 cattle belonging to five breeds, as well as to evaluate their effects on body measurement traits. Read More

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http://dx.doi.org/10.1007/s10528-018-9868-3DOI Listing
December 2018
16 Reads