3,331 results match your criteria Biochemical genetics[Journal]


Unleash the Association of Mitochondrial Uncoupling Protein (UCP2) Promoter Variant (G-866A; rs659366) with Obesity: Stepping from a Case-Control Study to a Meta-analysis.

Biochem Genet 2020 May 30. Epub 2020 May 30.

Department of Biochemistry, Faculty of Physical Therapy, Horus University - Egypt, New Damietta, Egypt.

Numerous eligible articles investigated the potential impact of the promoter region of UCP2 (rs659366) variant and the susceptibility for obesity with questionable outcomes. Our team designed this case-control combined with meta-analysis survey to illustrate the contribution of this variant with obesity. This case-control survey was formulated based on 110 obese Egyptian patients and 122 non-obese controls. Read More

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http://dx.doi.org/10.1007/s10528-020-09973-yDOI Listing

MELK Accelerates the Progression of Colorectal Cancer via Activating the FAK/Src Pathway.

Biochem Genet 2020 May 29. Epub 2020 May 29.

Department of Imaging, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Guiyang, 550004, Guizhou, China.

Maternal embryo leucine zipper kinase (MELK) has a higher expression level in a variety of cancers and involved in progression of colorectal cancer. The MELK expression levels in colorectal cancer tissues and cells were detected by RT-qPCR. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and transwell assays were used to examine the effect of the MELK konckdown on the proliferation, migration and invasion of colorectal cancer cells. Read More

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http://dx.doi.org/10.1007/s10528-020-09974-xDOI Listing

Suppression of miR-30a-3p Attenuates Hepatic Steatosis in Non-alcoholic Fatty Liver Disease.

Biochem Genet 2020 May 17. Epub 2020 May 17.

College of Pharmacy, Harbin Medical University, Harbin, 150001, People's Republic of China.

Non-alcoholic fatty liver disease (NAFLD) have a high prevalence in humans in the past two decades. Here, we elucidated the functions of miR-30a-3p in the development of NAFLD and identified its potential targets. HepG-2 cells and NAFLD patients' blood samples were used in our study. Read More

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http://dx.doi.org/10.1007/s10528-020-09971-0DOI Listing

Genome-Wide Identification and Analysis of the Growth-Regulating Factor (GRF) Gene Family and GRF-Interacting Factor Family in Triticum aestivum L.

Biochem Genet 2020 May 12. Epub 2020 May 12.

State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, 3 Taicheng Rd, Yangling, 712100, Shaanxi, People's Republic of China.

Growth-regulating factors (GRFs) are unique transcription factors in plants. GRFs can interact with SNH (SYT N-terminal homology) domains in GRF-interacting factor (GIF) proteins via the N-terminal QLQ (Gln, Leu, Gln) domain to form functional complexes and participate in the regulation of downstream gene expression. In this study, we systematically identified the GRF gene family and GIF gene family in wheat and its relatives comprising Triticum urartu, Triticum dicoccoides, and Aegilops tauschii. Read More

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http://dx.doi.org/10.1007/s10528-020-09969-8DOI Listing

High Resolution Melting (HRM) Genotyping in the Genus Origanum: Molecular Identification and Discrimination for Authentication Purposes.

Biochem Genet 2020 May 11. Epub 2020 May 11.

Department of Agriculture, University of Patras, Theodoropoulou Str, 27200, Amaliada, Greece.

Origanum L. (Lamiaceae) is an important genus of medicinal and aromatic plants used since ancient times as culinary herbs and remedies in traditional medicine. Although it is a relatively small genus, intra-generic species delineation, as well as its inter-generic relationships within tribe Mentheae, are still poorly understood. Read More

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http://dx.doi.org/10.1007/s10528-020-09970-1DOI Listing

Comparison of mRNA Expression of P2X Receptor Subtypes in Different Arterial Tissues of Rats.

Biochem Genet 2020 May 8. Epub 2020 May 8.

Department of Anesthesiology, Affiliated Hospital of Hebei University, No. 212 of Yuhua East Road, Lianchi District, Baoding, 071000, China.

This study aims to compare the expression of P2X receptor subtype mRNA in different arterial tissues of rats. After the rats were sacrificed, the internal carotid, pulmonary, thoracic aorta, mesenteric and caudal arteries were dissected out. Then, the P2X receptor mRNA expression in different blood vessels was detected by reverse transcription-polymerase chain reaction (RT-PCR) and real-time quantitative polymerase chain reaction. Read More

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http://dx.doi.org/10.1007/s10528-020-09968-9DOI Listing

Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease.

Biochem Genet 2020 May 5. Epub 2020 May 5.

Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center and German Center for Cardiovascular Research, Partner Site Göttingen, Göttingen, Germany.

Genetic variations affecting the course of depressive symptoms in patients with coronary artery disease (CAD) have not yet been well studied. Therefore, we set out to investigate whether distinct haplotypes of the two insertion/deletion polymorphisms in the serotonin-transporter-linked polymorphic region (5-HTTLPR) and the angiotensin I-converting enzyme (ACE) gene located on chromosome 17 can be identified as risk factors for trajectories of depression. Clinical and genotyping data were derived from 507 depressed CAD patients participating in the randomized, controlled, multicenter Stepwise Psychotherapy Intervention for Reducing Risk in Coronary Artery Disease (SPIRR-CAD) trial, of whom the majority had an acute cardiac event before study inclusion. Read More

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http://dx.doi.org/10.1007/s10528-020-09967-wDOI Listing

Descending Expression of miR320 in Insulin-Resistant Adipocytes Treated with Ascending Concentrations of Metformin.

Biochem Genet 2020 May 4. Epub 2020 May 4.

Department of Biochemistry and Molecular Biology, School of Medicine, ShahidSadoughi University of Medical Sciences, Yazd, Iran.

Some miRNAs are supposed to play a role in insulin resistance and metabolic disorders. Such miRNAs can be differentially expressed in response to a pharmacologic intervention for insulin resistance as a biomarker/risk factor for insulin resistance. This study aimed at determining the effect of Metformin on miR320 expression in insulin-resistant (IR) adipocytes. Read More

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http://dx.doi.org/10.1007/s10528-020-09964-zDOI Listing
May 2020
0.865 Impact Factor

Smoking-Related DNA Methylation is Differentially Associated with Cadmium Concentration in Blood.

Biochem Genet 2020 Apr 28. Epub 2020 Apr 28.

Division of Biobank for Health Sciences, Center for Genome Science, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Korea.

Tobacco smoking, a risk factor for several human diseases, can lead to alterations in DNA methylation. Smoking is a key source of cadmium exposure; however, there are limited studies examining DNA methylation alterations following smoking-related cadmium exposure. To identify such cadmium exposure-related DNA methylation, we performed genome-wide DNA methylation profiling using DNA samples from 50 smokers and 50 non-smokers. Read More

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http://dx.doi.org/10.1007/s10528-020-09965-yDOI Listing

The Impact of TRAIL (C1595T and G1525A) and DR4 (rs20576) Gene Polymorphisms on Systemic Lupus Erythematosus.

Biochem Genet 2020 Apr 27. Epub 2020 Apr 27.

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Apoptosis dysregulation is a distinct hallmark of several disorders like systemic lupus erythematosus (SLE). In fact, SLE has two special features for apoptosis: irregular apoptosis and decline in clearing of apoptotic bodies. Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) is a death ligand that causes to apoptosis via attaching to its receptors such as death receptor-4 (DR4). Read More

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http://dx.doi.org/10.1007/s10528-020-09966-xDOI Listing

Porphyromonas gingivalis Inhibition of MicroRNA-205-5p Expression Modulates Proinflammatory Cytokines in Gingival Epithelial Cells.

Biochem Genet 2020 Apr 17. Epub 2020 Apr 17.

Department of Stomatology, Yantai Yuhuangding Hospital, Zhifu District, No. 20 Yuhuangding East Road, Yantai, 264000, Shandong, China.

In this study, we strived to investigate the effect of miR-205-5p on JAK/STAT signaling way induced by P. gingivalis in periodontitis. Microarray analysis was conducted to find differentially expressed miRNAs in periodontitis patients. Read More

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http://dx.doi.org/10.1007/s10528-020-09957-yDOI Listing
April 2020
0.865 Impact Factor

Microsatellite Genotyping Corroborated Loss of Genetic Diversity in Clarias batrachus as a Result of Lack of Regulatory Reforms in Aquaculture.

Biochem Genet 2020 Apr 13. Epub 2020 Apr 13.

Paul Hebert Centre for DNA Barcoding and Biodiversity Studies, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004, India.

In India, over the past 50 years, aquaculture practices of species such as those used for Clarias batrachus were developed without adequate regulatory oversight. In these situations, it is important to consider the influence that genetic factors can have on such vulnerable aquaculture species. Population genetic structure can be evaluated through the use of neutral molecular markers, and this can aid in predicting the risk of the demise of populations and for framing management strategies to conserve remaining populations. Read More

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http://dx.doi.org/10.1007/s10528-020-09963-0DOI Listing

Endothelial Nitric Oxide Synthase (eNOS) Gene Polymorphisms and Markers of Hemolysis, Inflammation and Endothelial Dysfunction in Brazilian Sickle Cell Anemia Patients.

Biochem Genet 2020 Apr 10. Epub 2020 Apr 10.

Department of Clinical Pathology - School of Medical Sciences, State University of Campinas (UNICAMP), Rua Vital Brasil 50, Campinas, SP, 13083-888, Brazil.

The impaired bioavailability of endogenous nitric oxide (NO) in sickle cell anemia (SCA) may be influenced by polymorphisms in the endothelial nitric oxide synthase gene (eNOS). We compared allelic/genotypic frequencies of the eNOS polymorphisms T-786C, VNTR4a/b and G894T between 89 adult SCA patients and 100 healthy controls, and investigated the relationship between these SNPs and markers of hemolysis [lactate dehydrogenase (LDH), indirect bilirubin (IB) and reticulocyte counts], inflammation [interleukins IL-1β, IL-6, IL-8, Tumor Necrosis Factor (TNF-α) and C-reactive protein (CRP)] and endothelial dysfunction (ED) [soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble L-selectin (sL-selectin), von Willebrand Factor (vWF) antigen and D-dimers] in the patients. The frequencies of the mutant -786C allele and -786C/C genotype were significantly higher in patients (p = 0. Read More

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http://dx.doi.org/10.1007/s10528-020-09959-wDOI Listing

Evaluation of ASPM and TEF Gene Expressions as Potential Biomarkers for Bladder Cancer.

Biochem Genet 2020 Jun 9;58(3):490-507. Epub 2020 Apr 9.

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Yassin Abdel Ghaffar St., Shebin el-Kom, 32511, Egypt.

Bladder cancer is one of the most predominant tumors of the genitourinary tract. In addition to pathological findings, the molecular modifications that might affect tumorigenesis and tumor outcome should be considered when treating bladder cancer. Accordingly, we aimed to investigate the expression levels of both the ASPM and TEF genes in bladder cancer tissues and their value in disease prognosis. Read More

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http://dx.doi.org/10.1007/s10528-020-09962-1DOI Listing

Zoledronate Inhibits Osteoclast Differentiation via Suppressing Vascular Endothelial Growth Factor Receptor 2 Expression.

Biochem Genet 2020 Jun 9;58(3):473-489. Epub 2020 Apr 9.

Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-Ku, Hiroshima, 734-8553, Japan.

Bisphosphonate-related osteonecrosis of the jaw (ONJ) is a major oral complication; however, its pathogenesis remains unclear. Impairment of osteoclast differentiation by bisphosphonates may be associated with the pathogenesis of ONJ. In our previous study, we reported that the expression of the gene encoding nuclear factor of activated T cells c1 (NFATc1), a known osteoclast differentiation marker, was significantly silenced by zoledronate, a bisphosphonate, in mouse osteoclast precursor cells (mOCPCs) using cDNA microarray. Read More

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http://dx.doi.org/10.1007/s10528-020-09961-2DOI Listing

Population Genetics Coupled Chemical Profiling for Conservation Implications of Decalepis salicifolia (Bedd. ex Hook.f.) Venter, an Endemic and Critically Endangered Species of Western Ghats, India.

Biochem Genet 2020 Jun 27;58(3):452-472. Epub 2020 Mar 27.

Plant Biology and Systematics, CSIR - Central Institute of Medicinal and Aromatic Plants, Research Center, Bengaluru, Karnataka, 560 065, India.

Information on the genetic diversity and population structure is essential for developing conservational management programs, especially for threatened species. Decalepis salicifolia (Bedd. ex Hook. Read More

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http://dx.doi.org/10.1007/s10528-020-09958-xDOI Listing
June 2020
0.865 Impact Factor

Characterization of the Whole Mitogenome of Largehead Hairtail Trichiurus lepturus (Trichiuridae): Insights into Special Characteristics.

Biochem Genet 2020 Jun 13;58(3):430-451. Epub 2020 Mar 13.

ICAR- Central Marine Fisheries Research Institute, Ernakulam North P.O., Kochi, Kerala, 682018, India.

Mitochondrial genomes are valuable for making inferences regarding population genetics, phylogenetics and recently in understanding adaptive variation in OXPHOS genes. Ribbon fish, Trichiurus lepturus is distributed in the Indian Ocean and contributes to a major share of pelagic fish landings. Considering the importance, we characterized the complete mitogenome of large head hairtail T. Read More

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http://dx.doi.org/10.1007/s10528-020-09956-zDOI Listing
June 2020
0.865 Impact Factor

Genomic and Transcriptional Analysis of Banana Ovate Family Proteins Reveals Their Relationship with Fruit Development and Ripening.

Biochem Genet 2020 Jun 6;58(3):412-429. Epub 2020 Mar 6.

Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 4 Xueyuan Road, Haikou, 571101, China.

Ovate Family Proteins (OFPs) belong to a plant-specific transcription factor family. They have been found to have significant roles in growth and development in Arabidopsis and tomato; however, little is known regarding their role in banana. Thus, a genome-wide study of OFP genes in banana was conducted for the first time in the present study. Read More

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http://dx.doi.org/10.1007/s10528-020-09951-4DOI Listing

Evaluating the Genetic Correlations Between Left-Handedness and Mental Disorder Using Linkage Disequilibrium Score Regression and Transcriptome-Wide Association Study.

Biochem Genet 2020 Apr 25;58(2):348-358. Epub 2020 Feb 25.

Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yan Ta West Road, Xi'an, 710061, People's Republic of China.

Handedness is an elusive human behavioral phenotypes and the genetic basis of it remains unclear until now. The aim of this study is to evaluate the genetic correlations between left-handedness and multiple mental disorders, and explored the genes detected by genetic correlations. In this study, linkage disequilibrium score regression (LDSC) analysis was conducted to evaluate the genetic correlations between left-handedness and multiple mental disorders. Read More

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http://dx.doi.org/10.1007/s10528-020-09952-3DOI Listing

Molecular Characteristics, Phylogeny and Expression Profile of the PTEN Gene in Goats.

Biochem Genet 2020 Jun 4;58(3):399-411. Epub 2020 Feb 4.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.

Phosphatase and the tensin homologue deleted on chromosome ten (PTEN) has pleiotropic effects on cell growth, organ development, glucose metabolism and insulin resistance in mammals. In the present study, we investigated the molecular characteristics, phylogeny and expression profile of the PTEN gene in different tissues of Jianzhou Daer goats. In this study, eight different tissues from E90, E135 and D90 female goats were collected to quantify the expression pattern of the PTEN gene using quantitative real-time PCR (qPCR), western blotting and FISH. Read More

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http://dx.doi.org/10.1007/s10528-020-09947-0DOI Listing
June 2020
0.865 Impact Factor

WBSCR22 Competes with Long Non-coding RNA Linc00346 for miR-509-5p Binding Site to Regulate Cancer Stem Cell Phenotypes of Colorectal Cancer.

Biochem Genet 2020 Jun 1;58(3):384-398. Epub 2020 Feb 1.

Hepatobiliay Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 646000, Sichuan, China.

Various Long non-coding RNAs (lncRNAs) and MicroRNAs (miRNAs) have been demonstrated to be involved in colorectal cancer stem cells (CSCs). WBSCR22 is a key gene we previously found that functions in colorectal cancer (CRC). This paper aims to investigate the effects of WBSCR22 and its corresponding miRNA and lncRNA in CRC. Read More

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http://dx.doi.org/10.1007/s10528-020-09949-yDOI Listing

Association Between the Polymorphism of Aldehyde Dehydrogenase 2 Gene and Cerebral Infarction in a Hakka Population in Southern China.

Biochem Genet 2020 Apr 31;58(2):322-334. Epub 2020 Jan 31.

Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated To Sun Yat-Sen University, Meizhou, 514031, People's Republic of China.

Genetic factors play an important role in determining the susceptibility to ischemic stroke. Herein, we examined the association of an aldehyde dehydrogenase 2 (ALDH2) gene polymorphism with cerebral infarction. Patients with cerebral infarction (n = 963) and healthy controls (n = 921) were included. Read More

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http://dx.doi.org/10.1007/s10528-020-09950-5DOI Listing

Small Molecules with Big Impacts on Cardiovascular Diseases.

Biochem Genet 2020 Jun 29;58(3):359-383. Epub 2020 Jan 29.

Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Although in recent years there has been a significant progress in the diagnosis, treatment, and prognosis of CVD, but due to their complex pathobiology, developing novel biomarkers and therapeutic interventions are still in need. MicroRNAs (miRNAs) are a fraction of non-coding RNAs that act as micro-regulators of gene expression. Read More

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http://dx.doi.org/10.1007/s10528-020-09948-zDOI Listing

Functional Analysis of Sheep POU2F3 Isoforms.

Biochem Genet 2020 Apr 31;58(2):335-347. Epub 2019 Dec 31.

College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.

POU domain class 2 transcription factor 3 (POU2F3) plays an important role in keratinocyte proliferation and differentiation. Our previous study identified four sheep POU2F3 transcript variants (POU2F3-1, POU2F3-2, POU2F3-3, and POU2F3-4), encoding three POU2F3 protein isoforms (POU2F3-1, POU2F3-2, and POU2F3-3). However, the functional differences among the three POU2F3 isoforms remain unknown. Read More

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http://dx.doi.org/10.1007/s10528-019-09945-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113193PMC

Genetic Diversity and Structure Analysis Assessed by SSR Markers in a Large Collection of Vitis Cultivars from the Island of Crete, Greece.

Biochem Genet 2020 Apr 28;58(2):294-321. Epub 2019 Nov 28.

Laboratory of Plant Biotechnology, Hellenic Agricultural Organization DEMETER (Ex. NAGREF), Institute of Olive Tree, Sub-Tropical Crops and Viticulture, P.O. Box 2228, 71003, Heraklion, GR, Greece.

The grape (Vitis vinifera L.) cultivars in the island of Crete, Greece represent one of the oldest populations of the species; nevertheless, very scarce information is available about its genetic structure. In this study, Vitis cultivars collected from the island of Crete were characterized using microsatellite markers. Read More

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http://dx.doi.org/10.1007/s10528-019-09943-zDOI Listing

Epigenetic Modifications in Head and Neck Cancer.

Biochem Genet 2020 Apr 11;58(2):213-244. Epub 2019 Nov 11.

Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19 Str., 41-808, Zabrze, Katowice, Poland.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human malignancy in the world, with high mortality and poor prognosis for patients. Among the risk factors are tobacco and alcohol intake, human papilloma virus, and also genetic and epigenetic modifications. Many studies show that epigenetic events play an important role in HNSCC development and progression, including DNA methylation, chromatin remodeling, histone posttranslational covalent modifications, and effects of non-coding RNA. Read More

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http://dx.doi.org/10.1007/s10528-019-09941-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113219PMC

Haplogroup Structure and Genetic Variation Analyses of 60 Mitochondrial DNA Markers in Southern Shaanxi Han Population.

Biochem Genet 2020 Apr 6;58(2):279-293. Epub 2019 Nov 6.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.

Mitochondrial DNA (mtDNA) has been widely employed as one tool for the studies of human migration and phylogenetic evolution owing to the characteristics of its lack of recombination and matrilineal inheritance. In this study, we analyze genetic distributions of 60 mtDNA markers in 126 unrelated individuals of Southern Shaanxi Han population and classify their haplogroups. Genetic distribution comparisons between Southern Shaanxi Han and other populations from different continents are conducted based on the same mtDNA markers. Read More

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http://dx.doi.org/10.1007/s10528-019-09942-0DOI Listing

Retraction Note to: Inferring Phylogenetic Relationships of Indian Citron (Citrus medica L.) Based on rbcL and matK Sequences of Chloroplast DNA.

Biochem Genet 2020 02;58(1):210-211

Tissue Culture and Cryopreservation Unit, National Bureau of Plant Genetic Resources (NBPGR), Pusa Campus, New Delhi, India.

The Editor-in-Chief and the publisher have retracted this article [1] because of significant overlap with previously published articles [2-5]. Ajit Uchoi, Surendra Kumar Malik, Ravish Chaudhary, Susheel Kumar, M.R. Read More

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http://dx.doi.org/10.1007/s10528-019-09939-9DOI Listing
February 2020
0.865 Impact Factor

Association of the Variant rs7561317 Downstream of the TMEM18 Gene with Overweight/Obesity and Related Anthropometric Traits in a Sample of Pakistani Population.

Biochem Genet 2020 Apr 18;58(2):257-278. Epub 2019 Oct 18.

Molecular Biology and Human Genetics Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, 75270, Pakistan.

Obesity is a multifactorial disorder and requires favorable environment for its expression. However, some individuals are more prone to weight gain than others in an obesogenic environment. Thus, at individual level, who becomes overweight or obese is mostly determined by genetic factors. Read More

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http://dx.doi.org/10.1007/s10528-019-09940-2DOI Listing
April 2020
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Disruption of the Molecular Circadian Clock and Cancer: An Epigenetic Link.

Biochem Genet 2020 Feb 24;58(1):189-209. Epub 2019 Sep 24.

Institute of Neuroethology, Universidad Veracruzana, Xalapa, Veracruz, Mexico.

The circadian clock is regulated at the molecular level by feedback circuits of a group of genes known as "clock genes", which establish a mechanism that controls circadian cellular physiology to maintain the balance between cell proliferation, response to DNA damage and apoptosis. Alterations in the expression of clock genes due to genetic or epigenetic mechanisms have been associated with multiple diseases including cancer. Even some clock genes such as the Per1, Per2, Bmal1 genes have been proposed as tumor suppressor genes, with a relevant role during carcinogenesis. Read More

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http://dx.doi.org/10.1007/s10528-019-09938-wDOI Listing
February 2020
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Association Between MTHFR Gene Common Variants, Serum Homocysteine, and Risk of Early-Onset Coronary Artery Disease: A Case-Control Study.

Biochem Genet 2020 Apr 24;58(2):245-256. Epub 2019 Sep 24.

Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.

The common variants of the methylenetetrahydrofolate reductase (MTHFR) gene are related to the activity of the MTHFR enzyme and the concentrations of blood homocysteine (Hcy). This study was designed to investigate the associations of MTHFR in Chinese populations with early-onset coronary artery disease (EOCAD). The two common variants of the MTHFR gene were genotyped in 875 EOCAD patients and 956 controls using PCR, followed by direct sequencing of the PCR product. Read More

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http://dx.doi.org/10.1007/s10528-019-09937-xDOI Listing
April 2020
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Characterization and Analysis of Mammalian AKR7A Gene Promoters: Implications for Transcriptional Regulation.

Biochem Genet 2020 Feb 16;58(1):171-188. Epub 2019 Sep 16.

Department of Pharmacy, Brac University, 41, Pacific Tower, Mohakhali, Dhaka, 1212, Bangladesh.

Aldo-keto reductase (AKR) superfamily is responsible for preventing mammalian cells from the toxic and carcinogenic effect of different genotoxic and non-genotoxic chemicals by reducing them, though the inducibility of these genes are different in different species. The aim of this paper is to compare the gene regulation mechanisms of AKR superfamily genes in different species and to identify the conserved areas, which are responsible for gene regulations in the presence of antioxidant, toxicants, and non-genotoxic carcinogens. At the beginning of the analysis AKR genes found in different species were divided into two groups based on their amino acid sequence similarities. Read More

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http://dx.doi.org/10.1007/s10528-019-09936-yDOI Listing
February 2020

Correction to: Morphological Characterization and Gene Expression Patterns for Melanin Pigmentation in Rex Rabbit.

Biochem Genet 2019 10;57(5):746

College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.

The original article has been published with an incorrect grant number in the Funding section. Read More

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http://dx.doi.org/10.1007/s10528-019-09934-0DOI Listing
October 2019
0.865 Impact Factor

Genetic Diversity and Population Structure Analysis of Three Deep-Sea Amphipod Species from Geographically Isolated Hadal Trenches in the Pacific Ocean.

Biochem Genet 2020 Feb 13;58(1):157-170. Epub 2019 Aug 13.

Shanghai Engineering Research Center of Hadal Science & Technology, College of Marine Sciences, Shanghai Ocean University, Shanghai, 201306, China.

Amphipods of the superfamily Lysianassoidea that inhabit the hadal zone ( > 6000 m) have large bathymetric ranges and play a key role in deep ocean ecosystems. The endemism of these amphipod species makes them a good model for investigating potent natural selection and restricted dispersal in deep ocean trenches. Here, we describe genetic diversity and intraspecific population differentiation among three amphipod species from four Pacific trenches based on a mtDNA concatenated dataset (CO Ι and 16S rRNA genes) from 150 amphipod individuals. Read More

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http://dx.doi.org/10.1007/s10528-019-09935-zDOI Listing
February 2020

Morphological Characterization and Gene Expression Patterns for Melanin Pigmentation in Rex Rabbit.

Biochem Genet 2019 Oct 13;57(5):734-744. Epub 2019 Jul 13.

College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.

Animal melanin has an important role in the formation of animal fur and skin, which is determined by its quantities, character, and distribution. To identify the effect of melanin on the formation of multi-colored Rex rabbits (Black, Chinchilla, Beaver, Protein cyan, Protein yellow, White), the structure of hair follicles and melanin content in multi-colored Rex rabbit skins were observed by Hematoxylin and Eosin (H&E) staining and melanin staining, respectively. The melanin granules were primarily found in the epidermis and hair follicle roots. Read More

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http://link.springer.com/10.1007/s10528-019-09929-x
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http://dx.doi.org/10.1007/s10528-019-09929-xDOI Listing
October 2019
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0.865 Impact Factor

Biological Effects of Single-Nucleotide Polymorphisms in the Drosophila melanogaster Malic Enzyme Locus.

Biochem Genet 2020 Feb 13;58(1):129-156. Epub 2019 Jul 13.

Department of Chemistry & Biochemistry, Laurentian University, Sudbury, ON, P3E 2C6, Canada.

A pair of amino acid polymorphisms within the Drosophila melanogaster Malic enzyme (Men) locus presents an interesting case of genetic variation that appears to be under selection. The two alleles at each site are biochemically distinct, but their biological effects are unknown. One polymorphic site is near the active site and the other is buried within the protein. Read More

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http://dx.doi.org/10.1007/s10528-019-09932-2DOI Listing
February 2020
1 Read

Genome Wide Identification, Molecular Characterization, and Gene Expression Analyses of Grapevine NHX Antiporters Suggest Their Involvement in Growth, Ripening, Seed Dormancy, and Stress Response.

Biochem Genet 2020 Feb 8;58(1):102-128. Epub 2019 Jul 8.

Laboratory of Extremophile Plants, Center of Biotechnology of Borj-Cédria, B.P. 901, 2050, Hammam-lif, Tunisia.

Plant NHX antiporters are critical for cellular pH, Na, and K homeostasis and salt tolerance. Even though their genomic and functional studies have been conducted in many species, the grapevine NHX family has not been described yet. Our work highlights the presence of six VvNHX genes whose phylogenetic analysis revealed their classification in two distinct groups: group I vacuolar (VvNHX1-5) and group II endosomal (VvNHX6). Read More

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http://dx.doi.org/10.1007/s10528-019-09930-4DOI Listing
February 2020
2 Reads

Additive Diagnostic Yield of Homozygosity Regions Identified During Chromosomal microarray Testing in Children with Developmental Delay, Dysmorphic Features or Congenital Anomalies.

Biochem Genet 2020 Feb 4;58(1):74-101. Epub 2019 Jul 4.

Cytogenetics Unit, Al Borg Medical Laboratories, Jeddah, Kingdom of Saudi Arabia.

Chromosomal microarray (CMA) has emerged as a robust tool for identifying microdeletions and microduplications, termed copy number variants (CNVs). Nevertheless, data regarding its utility in different patient populations with developmental delay (DD), dysmorphic features (DF) and congenital anomalies (CA), is a matter of dense debate. Although regions of homozygosity (ROH) are not diagnostic of a specific condition, they may have pathogenic implications. Read More

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http://dx.doi.org/10.1007/s10528-019-09931-3DOI Listing
February 2020
0.865 Impact Factor

Upregulation of Pro-inflammatory Cytokine Genes by Parvovirus B19 in Human Bone Marrow Mesenchymal Stem Cells.

Biochem Genet 2020 Feb 27;58(1):63-73. Epub 2019 Jun 27.

Department of Medical Biotechnology, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, 34199-15315, Iran.

Chronic inflammation plays a prominent role in cancer initiation and development. On the other hand, the Inflammation can be established by a number of factors such as viral infections. Parvovirus B19 (B19V) is a pathogen with widespread infection, which infects bone marrow erythroid progenitor cells. Read More

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http://dx.doi.org/10.1007/s10528-019-09928-yDOI Listing
February 2020
4 Reads

Identification, Expression, and Interaction Network Analyses of the CDPK Gene Family Reveal Their Involvement in the Development, Ripening, and Abiotic Stress Response in Banana.

Biochem Genet 2020 Feb 29;58(1):40-62. Epub 2019 May 29.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, China.

Calcium-dependent protein kinases (CDPKs) play vital roles in the regulation of plant growth, development, and tolerance to various abiotic stresses. However, little information is available for this gene family in banana. In this study, 44 CDPKs were identified in banana and were classified into four groups based on phylogenetic, gene structure, and conserved motif analyses. Read More

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http://dx.doi.org/10.1007/s10528-019-09916-2DOI Listing
February 2020
2 Reads

Expression of Concern: Genetic Diversity Among Historical Olive (Olea europaea L.) Genotypes from Southern Anatolia Based on SSR Markers.

Biochem Genet 2019 06;57(3):475

Department of Horticulture, Agricultural Faculty, Ataturk University, Erzurum, Turkey.

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http://dx.doi.org/10.1007/s10528-019-09923-3DOI Listing
June 2019
1 Read

A Novel Method for Identifying the Potential Cancer Driver Genes Based on Molecular Data Integration.

Biochem Genet 2020 Feb 21;58(1):16-39. Epub 2019 May 21.

College of Computer Science and Electronics Engineering, Hunan University, Changsha, 410082, Hunan, China.

The identification of the cancer driver genes is essential for personalized therapy. The mutation frequency of most driver genes is in the middle (2-20%) or even lower range, which makes it difficult to find the driver genes with low-frequency mutations. Other forms of genomic aberrations, such as copy number variations (CNVs) and epigenetic changes, may also reflect cancer progression. Read More

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http://dx.doi.org/10.1007/s10528-019-09924-2DOI Listing
February 2020
3 Reads
0.865 Impact Factor

Complete Genome of Bacillus velezensis CMT-6 and Comparative Genome Analysis Reveals Lipopeptide Diversity.

Biochem Genet 2020 Feb 17;58(1):1-15. Epub 2019 May 17.

Department of Wine, Food and Molecular Biosciences, Lincoln University, Lincoln, 7647, New Zealand.

The complete genome sequence of Bacillus velezensis type strain CMT-6 is presented for the first time. A comparative analysis between the genome sequences of CMT-6 with the genome of Bacillus amyloliquefaciens DSM7, B. velezensis FZB42, and Bacillus subtilis 168 revealed major differences in the lipopeptide synthesis genes. Read More

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http://dx.doi.org/10.1007/s10528-019-09927-zDOI Listing
February 2020
4 Reads
0.865 Impact Factor

NEMP1 Promotes Tamoxifen Resistance in Breast Cancer Cells.

Biochem Genet 2019 Dec 11;57(6):813-826. Epub 2019 May 11.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.

Breast cancer (BC) is a worldwide malignant and a leading death cancer in women. Studies have shown that adjuvant tamoxifen reduces the recurrence rate and metastasis in BC. Even though tamoxifen has been used for the therapy of BC for decades, the resistance of it on BC cells could not be ignored. Read More

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http://dx.doi.org/10.1007/s10528-019-09926-0DOI Listing
December 2019
1 Read

Tissue-Specific Monoallelic Expression of Bovine AXL is Associated with DNA Methylation of Promoter DMR.

Biochem Genet 2019 Dec 9;57(6):801-812. Epub 2019 May 9.

College of Life Science, Agricultural University of Hebei, Baoding, 071001, China.

The AXL protein is a receptor tyrosine kinase and is often implicated in proliferation, migration and therapy resistance in various cancers. The AXL gene in humans is maternally expressed and paternally imprinted with differentially methylated regions (DMR) surrounding the promoter region. However, the imprinting status and epigenetic regulation of AXL gene in cattle remain unclear. Read More

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http://dx.doi.org/10.1007/s10528-019-09925-1DOI Listing
December 2019
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Genome-Wide Identification and Comparative Expression Profile Analysis of the Long-Chain Acyl-CoA synthetase (LACS) Gene Family in Two Different Oil Content Cultivars of Brassica napus.

Biochem Genet 2019 Dec 22;57(6):781-800. Epub 2019 Apr 22.

Chongqing Engineering Research Center for Rapeseed, College of Agronomy and Biotechnology, Southwest University, Chongqing, 400715, China.

Long-chain acyl-CoA synthetase (LACS) is one of the key enzymes involved in fatty acid metabolism, including phospholipid biosynthesis, triacylglycerol (TAG) biosynthesis, and fatty acid β-oxidation in plants. However, the characterization of LACSs family in seed oil biosynthesis of Brassica napus (B. napus) remains unknown. Read More

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http://link.springer.com/10.1007/s10528-019-09921-5
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http://dx.doi.org/10.1007/s10528-019-09921-5DOI Listing
December 2019
15 Reads
0.865 Impact Factor

Altered miR-21, miRNA-148a Expression in Relation to KRAS Mutation Status as Indicator of Adenoma-Carcinoma Transitional Pattern in Colorectal Adenoma and Carcinoma Lesions.

Biochem Genet 2019 Dec 17;57(6):767-780. Epub 2019 Apr 17.

Colorectal Cancer Research Center and Department of Biochemistry, Shiraz University of Medical Sciences, P.O Box 1167, Shiraz, Iran.

Sporadic colorectal cancer (CRC) is a fatal disease, mostly known as the silent killer, due to the fact that this disease is asymptomatic before diagnosis in advanced stage. Screening and the early detection of CRC and colorectal adenoma (CRA) by non-aggressive molecular biomarkers' signature is useful for improvement of survival rate in CRC patients. To achieve such a goal, a better understanding of distinct molecular abnormalities as candidate biomarkers in CRC development is crucial. Read More

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http://dx.doi.org/10.1007/s10528-019-09918-0DOI Listing
December 2019
2 Reads

Expanding Phaseolus coccineus Genomic Resources: De Novo Transcriptome Assembly and Analysis of Landraces 'Gigantes' and 'Elephantes' Reveals Rich Functional Variation.

Biochem Genet 2019 Dec 17;57(6):747-766. Epub 2019 Apr 17.

Institute of Applied Biosciences, CERTH, Thermi, 570 01, Thessaloniki, Greece.

Beans are one of the most important staple crops in the world. Runner bean (Phaseolus coccineus L.) is a small-scale agriculture crop compared to common bean (Phaseolusvulgaris). Read More

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http://dx.doi.org/10.1007/s10528-019-09920-6DOI Listing
December 2019
11 Reads

Genome-Wide Identification of the Aux/IAA Family Genes (MdIAA) and Functional Analysis of MdIAA18 for Apple Tree Ideotype.

Biochem Genet 2019 Oct 17;57(5):709-733. Epub 2019 Apr 17.

Department of Pomology, College of Horticulture, China Agricultural University, Yuanmingyuan West Road No. 2, Haidian District, Beijing, 100193, People's Republic of China.

The Aux/IAA (auxin/indole-3-acetic acid) gene family is one of the early auxin-responsive gene families, which play a central role in auxin response. Few reports are involved in Aux/IAA genes in fruit trees, especially in apple (Malus × domestica Borkh.). Read More

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http://dx.doi.org/10.1007/s10528-019-09919-zDOI Listing
October 2019
3 Reads