85,689 results match your criteria Biochemical and biophysical research communications[Journal]


A calcium-dependent phospholipase A2 (cPLA2) expression is regulated by MIG-6 during endometrial tumorigenesis.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, College of Human Medicine, Grand Rapids, MI, 49503, USA. Electronic address:

The ovarian steroid hormones, estrogen (E2) and progesterone (P4), are essential regulators of uterine biology. The imbalance of these ovarian steroid hormones leads to uterine diseases such as endometrial cancer, endometriosis, and infertility. Mitogen-inducible gene 6 (MIG-6) is an adaptor protein. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.034DOI Listing
February 2019

8-Nitro-cGMP attenuates context-dependent fear memory in mice.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan. Electronic address:

We previously reported that 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) is endogenously produced via nitric oxide/reactive oxygen species signaling pathways and it reacts with protein thiol residues to add cGMP structure to proteins through S-guanylation. S-Guanylation occurs on synaptosomal-associated protein 25 (SNAP-25), which is a part of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex that regulates exocytosis. However, the biological relevance of 8-nitro-cGMP in the nervous system remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.138DOI Listing
February 2019

Multi-site phosphorylation controls the neurogenic and myogenic activity of E47.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK; Wellcome Trust/MRC Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK. Electronic address:

The superfamily of basic-Helix-Loop-Helix (bHLH) transcription factors influence cell fate in all three embryonic germ layers, and the tissue-specific class II factors have received prominent attention for their potent ability to direct differentiation during development and in cellular reprogramming. The activity of many class II bHLH proteins driving differentiation, and the inhibitory class VI bHLH factor Hes1, is controlled by phosphorylation on multiple sites by Cyclin-dependent kinases (Cdks). As class II proteins are generally thought to be active through hetero-dimerisation with the ubiquitously expressed class I E proteins, regulation of class I transcription factors such as E47 may influence the activity of multiple tissue-specific bHLH proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.045DOI Listing
February 2019

Loss of Emp2 compromises cardiogenic differentiation in mouse embryonic stem cells.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Cellular Genetics (CEGE), Department of Biology, Faculty of Science and Bioengineering Sciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium. Electronic address:

Isolated mouse embryonic stem cells (mESCs) retain the capacities to self-renew limitlessly and to give rise to all tissues of an adult mouse. A precise understanding of the relationships, mechanisms of action and functions of novel genes involved in mESCs differentiation is crucial to expand our knowledge of vertebrate development. The epithelial membrane protein 2 (EMP2) is a membrane-spanning protein found in epithelial and endothelial cell-cell junctions that has been implicated in the regulation of cell proliferation and migration in normal and tumor tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.048DOI Listing
February 2019

Corrigendum to "The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss" [Biochem. Biophys. Res. Commun. 509 (3) (2019) 641-646].

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical Laboratory, Inner Mongolia People's Hospital, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.132DOI Listing
February 2019

Crystal structure of substrate-bound bifunctional proline racemase/hydroxyproline epimerase from a hyperthermophilic archaeon.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Department of Bioscience, Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime, 790-8566, Japan; Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime, 790-8566, Japan.

The hypothetical OCC_00372 protein from Thermococcus litoralis is a member of the ProR superfamily from hyperthermophilic archaea and exhibits unique bifunctional proline racemase/hydroxyproline 2-epimerase activity. However, the molecular mechanism of the broad substrate specificity and extreme thermostability of this enzyme (TlProR) remains unclear. Here we determined the crystal structure of TlProR at 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.141DOI Listing
February 2019

Knockdown of aristaless-like homeobox1 inhibits epithelial-mesenchymal transition through Wnt/β-catenin signaling pathway in melanoma cells.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, 014010, China. Electronic address:

Aristaless-like homeobox1 (ALX1), a member of the ALX family, is capable of mediating survival and development of mesenchyme-derived elements in vertebrates and its mutation will prevent the fusion of frontonasal and maxillary elements. Recently, ALX1 has been reported to be associated with cancer progression. However, the specific roles of ALX1 in melanoma remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.050DOI Listing
February 2019

Corticosteroids protect infected cells against mycobacterial killing in vitro.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Infectious Diseases Clinic, Umeå University Hospital, SE-901 85, Umeå, Sweden. Electronic address:

The effect of corticosteroids on human physiology is complex and their use in tuberculosis patients remains controversial. In a high-throughput screening approach designed to discover virulence inhibitors, several corticosteroids were found to prevent cytolysis of fibroblasts infected with mycobacteria. Further experiments with Mycobacterium tuberculosis showed anti-cytolytic activity in the 10 nM range, but no effect on bacterial growth or survival in the absence of host cells at 20 μM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.044DOI Listing
February 2019

Characterization of crystal structure and key residues of Aspergillus fumigatus nucleoside diphosphate kinase.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Center for Disease Control and Prevention of Chinese PLA, Beijing, 100071, China. Electronic address:

Aspergillus fumigatus is a major pathogen of invasive pulmonary aspergillosis with high mortality rate. The nucleoside diphosphate kinase of A. fumigatus, AfNDK (also called SwoH) is essential for its viability, however, its structural characteristic was unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.126DOI Listing
February 2019

Dulaglutide ameliorates STZ induced AD-like impairment of learning and memory ability by modulating hyperphosphorylation of tau and NFs through GSK3β.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Pathophysiology Department, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. Electronic address:

Dulaglutide, a novel long-acting glucagon-like peptide 1 (GLP-1) receptor agonist, is an incretin mimetic approved for type 2 diabetes mellitus (T2DM) treatment. Alzheimer's disease (AD) is called type 3 diabetes. The aim of this study is to explore the effects of dulaglutide on the learning and memory impairment in AD mice induced by injection of streptozocin (STZ) via intracerebroventricularly (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.103DOI Listing
February 2019

PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.

Biochem Biophys Res Commun 2019 Feb 13. Epub 2019 Feb 13.

Division of Immune Regulation, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan. Electronic address:

Cancer immunotherapies targeting programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte antigen 4 revolutionized cancer treatment and instigated various trials to develop new cancer immunotherapies with higher therapeutic efficacy. Agonistic Abs against tumor necrosis factor receptor super family (TNFRSF) molecules are highly expected due to their high potential to enhance survival, proliferation, and effector function of T cells. To date, agonistic antibodies (Abs) against CD27, GITR, OX40, and 4-1BB have been reported to increase the efficacy of anti-PD-1 therapy in animal models and clinical trials of these combinatorial therapies are underway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.004DOI Listing
February 2019

Role of eosinophils in a murine model of inflammatory bowel disease.

Biochem Biophys Res Commun 2019 Feb 13. Epub 2019 Feb 13.

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan.

Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD), which is triggered spontaneously by unknown mechanisms and manifests as chronic and relapsing inflammatory conditions in the colon. Eosinophil infiltration is often observed in the colonic tissue of ulcerative colitis patients. However, the role of eosinophils in the disease has not been well defined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.056DOI Listing
February 2019

CD133 promotes the self-renewal capacity of thyroid cancer stem cells through activation of glutamate aspartate transporter SLC1A3 expression.

Biochem Biophys Res Commun 2019 Feb 13. Epub 2019 Feb 13.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. Electronic address:

CD133+ cancer stem cells are responsible for thyroid cancer initiation. The regulatory pathways essential for sustaining the self-renewal of thyroid cancer stem cells remain largely unknown. Glutamate signaling regulates the self-renewal ability of stem cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.023DOI Listing
February 2019

Annexin A2 is involved in activation of extracellular signal-regulated kinase upon endothelin-1 stimulation.

Biochem Biophys Res Commun 2019 Feb 13. Epub 2019 Feb 13.

Department of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

The overexpression of endothelin (ET)-1 or ET receptors (ETRs) is related to initiation and progression of tumor. In cancer cells, ET-1 activates various signaling pathways, including mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase C through ETRs, although the mechanisms by which ET-1 activates these signaling pathways remain uncertain. Here, we found that ETRs interacted with annexin A2, which is overexpressed in various cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.040DOI Listing
February 2019

Glycyl-tRNA synthetase from Nanoarchaeum equitans: The first crystal structure of archaeal GlyRS and analysis of its tRNA glycylation.

Biochem Biophys Res Commun 2019 Feb 13. Epub 2019 Feb 13.

Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan; Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. Electronic address:

This study reports the X-ray crystallographic structure of the glycyl-tRNA synthetase (GlyRS) of Nanoarchaeum equitans - a hyperthermophilic archaeal species. This is the first archaeal GlyRS crystal structure elucidated. The GlyRS comprises an N-terminal catalytic domain and a C-terminal anticodon-binding domain with a long β-sheet inserted between these domains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.142DOI Listing
February 2019

Cancer upregulated gene (CUG)2 elevates YAP1 expression, leading to enhancement of epithelial-mesenchymal transition in human lung cancer cells.

Biochem Biophys Res Commun 2019 Feb 13. Epub 2019 Feb 13.

BK21 Plus, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, 46241, Republic of Korea. Electronic address:

Although our previous studies have showed that a novel oncogene, cancer upregulated gene (CUG)2 induced epithelial-mesenchymal transition (EMT), the detailed molecular mechanism remains unknown. Because several lines of evidence documented that Yes-Associated Protein (YAP)1 is closely associated with cancer stem cell (CSC)-like phenotypes including EMT, stemness, and drug resistance, we wondered if YAP1 is involved in CUG2-induced EMT. We herein found that the overexpression of CUG2 increased YAP1 expression at the transcriptional as well as protein levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.036DOI Listing
February 2019

Long non-coding RNA DNM3OS promotes tumor progression and EMT in gastric cancer by associating with Snail.

Biochem Biophys Res Commun 2019 Feb 12. Epub 2019 Feb 12.

Department of Gastrointestinal Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. Electronic address:

Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in tumor development and progression. In the present study, we explored the expression and biological role of the lncRNA DNM3OS in gastric cancer (GC). We observed that DNM3OS was upregulated in GC tissues and cell lines, and high DNM3OS expression was correlated with malignant features and served as an indicator of a poor prognosis for GC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.030DOI Listing
February 2019

NO in the dPAG modulates panic-like responses and ASIC1a expression in the prefrontal cortex and hippocampus in mice.

Biochem Biophys Res Commun 2019 Feb 12. Epub 2019 Feb 12.

Department of Medical Psychology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, 210029, China. Electronic address:

Panic disorder (PD) is a multifactorial neuropsychiatric disorder. Our previous study has demonstrated that the nitric oxide (NO) pathway and the acid-sensing ion channel 1a (ASIC1a) level in the dorsal midbrain periaqueductal gray (dPAG) are involved in the modulation of panic-like responses. In addition, the prefrontal cortex (PFC) and the hippocampus also play a role in panic-like responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.020DOI Listing
February 2019

Low-concentration HCP1 inhibits apoptosis in vascular endothelial cells.

Biochem Biophys Res Commun 2019 Feb 13. Epub 2019 Feb 13.

Institute of Medical Sciences, The Second Hospital of Shandong University, Jinan, 250033, PR China. Electronic address:

Vascular endothelial cell (VEC) apoptosis takes part in the development of various cardiovascular diseases. Heat shock protein 90 (HSP90) regulates apoptosis through various apoptosis associated client proteins. In previous study, we identified a novel HSP90 inhibitor HCP1 induced apoptosis in A549 human lung cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.003DOI Listing
February 2019

Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.

Biochem Biophys Res Commun 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Number 1, Youyi Road Yuzhong District, 400042, Chongqing, China. Electronic address:

Glucagon-like peptide-1 (GLP-1) and its receptor, GLP-1R, are valuable tools in the therapy of type 2 diabetes mellitus. Although GLP-1R stimulation is also potentially applicable to neurological disorders, few investigators have evaluated its beneficial effects in neurological disease models. Thus, we aimed to look into the antiepileptic effects of GLP-1R on epilepsy and its underlying mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.028DOI Listing
February 2019

Genetic deletion of β adrenergic receptors exacerbates hepatocellular lipid accumulation in high-fat diet mice.

Biochem Biophys Res Commun 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; The Key Laboratory for Drug Target Research and Pharmacodynamic Evaluation of Hubei Province, Wuhan, 430030, China. Electronic address:

β Adrenergic receptors (βARs) are G protein-coupled receptors (GPCRs) that are expressed in major insulin target tissues. βARs play an important role in the regulation of lipid metabolism during aging; however, little is known about the significance of βARs in the pathogenesis of hepatic fat accumulation in high-fat diet (HFD) mice. This study aims to examine the role of βAR in the development of nonalcoholic fatty liver disease (NAFLD) induced by HFD and the underlying mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.037DOI Listing
February 2019

MYCN-induced E2F5 promotes neuroblastoma cell proliferation through regulating cell cycle progression.

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatrics, The Second Xiangya Hospital, Central South University, PR China.

The MYCN oncoprotein induces the proliferation of neuroblastoma cells through regulating gene transcription. The E2F transcription factor 5 (E2F5) plays an oncogenic role in several types of cancer, however, its role in neuroblastoma cells remains poorly characterized. We report here that MYCN positively regulates E2F5 expression in neuroblastoma cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.087DOI Listing
February 2019

Inhibition of gastric cancer cell growth by a PI3K-mTOR dual inhibitor GSK1059615.

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

Endoscopy Center, Minhang Hospital, Fudan University, Shanghai, China. Electronic address:

Gastric cancer (GC) is a common malignancy. Developing novel and efficient anti-GC agents is urgent. GSK1059615 is a PI3K (phosphatidylinositol 3-kinase) and mTOR (mammalian target of rapamycin) dual inhibitor. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X193021
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2019.02.032DOI Listing
February 2019
1 Read

Structural analysis of molybdopterin synthases from two mycobacterial pathogens.

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China; College of Life Science, Nankai University, Tianjin, China; Laboratory of Structural Biology, Tsinghua University, Beijing, China.

The molybdenum cofactor, composed of molybdopterin and molybdenum, is a necessary compound for the catalytic activity of molybdenum enzymes. Molybdenum cofactor biosynthesis is a conserved multi-step process involving several enzymes. Molybdopterin synthase, a hetero-tetrameric enzyme composed of a pair of MoaE-MoaD subunits, catalyzes the generation of the cis-dithiolene group of molybdopterin in the second step of the process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.024DOI Listing
February 2019

Glycosylation differentially modulates membranolytic and chaperone-like activities of PDC-109, the major protein of bovine seminal plasma.

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India. Electronic address:

The major bovine seminal plasma protein, PDC-109, is a mixture of glycosylated (BSP-A1) and non-glycosylated (BSP-A2) isoforms of a 109-residue long polypeptide. It binds to spermatozoa by specifically recognizing choline phospholipids on the plasma membrane and destabilizes it by penetrating the hydrophobic interior, resulting in lipid efflux, which is necessary for sperm capacitation and successful fertilization. PDC-109 also acts as a molecular chaperone and protects target proteins from denaturation and aggregation induced by various types of stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.002DOI Listing
February 2019

Corrigendum to "Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress" Biochem. Biophys. Res. Commun. 508 (2019): 243-249.

Biochem Biophys Res Commun 2019 Feb 12. Epub 2019 Feb 12.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.027DOI Listing
February 2019

MicroRNA-552 promotes migration and invasion of osteosarcoma through targeting TIMP2.

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopaedics, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710077, China. Electronic address:

Aberrant miRNAs play important roles in tumor development and progression. Previous studies reported that miR-552 was dysregulated expressed in multiple cancers. However, its biological effects and underlying mechanism in osteosarcoma remains largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.007DOI Listing
February 2019

TRUSS inhibition protects against high fat diet (HFD)-stimulated brain injury by alleviation of inflammatory response.

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

Department of Anesthesiology, The Affiliated Huxi Hospital of Jining Medical College, Shanxian Central Hospital, Shanxian, Shandong, 274300, China. Electronic address:

High fat diet (HFD)-induced obesity is associated with insulin resistance (IR) and other chronic, diet associated illnesses, including neuroinflammation and brain injury. However, the involvement of inflammatory response in HFD-elicited central nerve injury has yet to be fully determined. Recent studies have indicated that tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein (TRUSS), also known as TRPC4AP, plays an essential role in regulating inflammation via the meditation of NF-κB signaling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.058DOI Listing
February 2019

TRAF1 meditates lipopolysaccharide-induced acute lung injury by up regulating JNK activation.

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatrics, Ankang Central Hospital, Ankang, 725000, China. Electronic address:

Acute lung injury (ALI) is served as a severe life-threatening disease. However, the pathogenesis that contributes to ALI has not been fully understood. Tumor necrosis factor receptor-associated factor 1 (TRAF1) interacts with multiple regulators, performing its diverse role in biological functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.041DOI Listing
February 2019

Ionic strength and calcium regulate membrane interactions of myelin basic protein and the cytoplasmic domain of myelin protein zero.

Biochem Biophys Res Commun 2019 Feb 9. Epub 2019 Feb 9.

Department of Biomedicine, University of Bergen, Bergen, Norway; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland. Electronic address:

The formation of a mature myelin sheath in the vertebrate nervous system requires specific protein-membrane interactions. Several myelin-specific proteins are involved in stacking lipid membranes into multilayered structures around axons, and misregulation of these processes may contribute to chronic demyelinating diseases. Two key proteins in myelin membrane binding and stacking are the myelin basic protein (MBP) and protein zero (P0). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.025DOI Listing
February 2019

Crystal structure of the C-terminal domain of the primosomal DnaT protein: Insights into a new oligomerization mechanism.

Biochem Biophys Res Commun 2019 Feb 9. Epub 2019 Feb 9.

School of Biomedical Sciences, Chung Shan Medical University, No.110, Sec.1, Chien-Kuo N. Rd., Taichung City, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, No.110, Sec.1, Chien-Kuo N. Rd., Taichung City, Taiwan. Electronic address:

DnaT is a replication restart primosomal protein required for re-initiating chromosomal DNA replication in bacteria. DnaT can be a monomer, dimer, trimer, tetramer, or pentamer. The oligomerization and disassembly of DnaT oligomers are critical in primosome assembly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.026DOI Listing
February 2019

Oxygen partial pressure plays a crucial role in B16 melanoma cell survival by regulating autophagy and mitochondrial functions.

Biochem Biophys Res Commun 2019 Feb 8. Epub 2019 Feb 8.

Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China; Institute of Biological Sciences, Jinzhou Medical University, Jinzhou, Liaoning, China. Electronic address:

The oxygen partial pressure generally increases when cancerous cells become part of the blood vessels. The study was to investigate the influence of oxygen partial pressure on the apoptosis of B16 melanoma cells. Our results demonstrated that both short-term and long-term hypoxia/reoxygenation (H/R) treatment increased stress-induced intracellular reactive oxygen species (ROS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.135DOI Listing
February 2019
1 Read

CircRNA hsa-circ-0014359 promotes glioma progression by regulating miR-153/PI3K signaling.

Biochem Biophys Res Commun 2019 Feb 8. Epub 2019 Feb 8.

Department of Orthopedics, Chu Hsien-I Memorial Hospital (Metabolic Diseases Hospital), Tianjin Medical University, Tianjin, 300070, China; NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

RNA back splicing produces circRNA, a new type of non-coding RNA. Studies have indicated that circRNAs play important roles in malignant tumors of the central nervous system. Here, we aimed to evaluate the expression of the circRNA, hsa-circ-0014359 (circ-0014359) in human glioma cell lines to assess its function in glioma progression and prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.019DOI Listing
February 2019

TORC1 regulates the DNA damage checkpoint via checkpoint protein levels.

Biochem Biophys Res Commun 2019 Feb 8. Epub 2019 Feb 8.

Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan; Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan. Electronic address:

Target of rapamycin complex 1 (TORC1) protein kinase, a master controller of cell growth, is thought to be involved in genome integrity. However, the molecular mechanisms associated with this are unclear. Here, we show that TORC1 inactivation causes decreases in the levels of a wide range of proteins involved in the DNA damage checkpoint (DDC) signaling including Tel1, Mre11, Rad9, Mrc1, and Chk1 in budding yeast. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.010DOI Listing
February 2019

Targeting eIF4E signaling with ribavirin as a sensitizing strategy for ovarian cancer.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

The First Clinical College, Hubei University of Chinese Medicine, Wuhan, Hubei, China. Electronic address:

The essential roles of eukaryotic translation initiation factor 4E (eIF4E) have been shown in various cancers, including ovarian cancer. In this work, we demonstrate that eIF4E inhibition in ovarian cancer can be achieved by ribavirin, a FDA-approved antiviral drug. We show that ribavirin at clinically relevant doses significantly inhibits growth and survival in multiple ovarian cancer cell lines, regardless of morphological and molecular subtypes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.117DOI Listing
February 2019
1 Read

PPARβ/δ agonist GW501516 inhibits TNFα-induced repression of adiponectin and insulin receptor in 3T3-L1 adipocytes.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, 25451, Republic of Korea. Electronic address:

Previous reports have shown that PPARβ/δ agonists ameliorate insulin resistance associated with type 2 diabetes mellitus (T2DM). To determine the role of PPARβ/δ in tumor necrosis factor α (TNFα)-mediated insulin resistance, we investigated expression levels of adiponectin and insulin receptor (IR) in response to treatment with the PPARβ/δ agonist GW501516 with or without TNFα, a proinflammatory cytokine, in differentiated 3T3-L1 adipocytes. GW501516 induced adipocyte differentiation and the expression of adiponectin in a dose-dependent manner in differentiated adipocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.013DOI Listing
February 2019
1 Read
2.297 Impact Factor

Identification and functional analysis of candidate gene VPS28 for milk fat in bovine mammary epithelial cells.

Authors:
Lily Liu Qin Zhang

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory of Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. Electronic address:

In a previous genome-wide association study on milk production traits in Chinese Holstein population, we revealed VPS28 gene was highly expressed in mammary gland tissue and a -58C > T mutation in 5'-UTR of it was significantly associated with milk fat content traits. In this study, we explored the effect of this -58C > T mutation on VPS28, and found it could significantly decrease promoter activity of VPS28 by reducing transcription factor binding sites. To identify the potential functional SNP involved, we performed RNAi experiment in BMECs, the results showed that VPS28 knockdown could increase the expression of ADFP and CD36, lead accumulation of ubiquitinated proteins, long chain fatty acids and triglyceride, and decrease the proteasome activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.016DOI Listing
February 2019

Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Raman Project Center for Medical and Biological Applications, Shimane University, Matsue, Shimane, 690-8504, Japan; Institute of Agricultural and Life Sciences, Academic Assembly, Shimane University, Matsue, Shimane, 690-8504, Japan; Estuary Research Center, Shimane University, Matsue, Shimane, 690-8504, Japan. Electronic address:

Intestinal bacteria produce skatole (3-methylindole) from tryptophan in dietary proteins and ingesting large quantities of animal protein is associated with increased fecal skatole concentrations. Although possibly associated with disrupted intestinal homeostasis, the influence of skatole on intestinal epithelial cellular function has not been characterized in detail. The present study aimed to determine whether skatole induces intestinal epithelial cell (IEC) dysfunction. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X193015
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2019.01.122DOI Listing
February 2019
1 Read

Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Sendai, 980-8578, Japan; Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan. Electronic address:

Systemic lupus erythematosus (SLE) increases the risk of preterm birth and preeclampsia (PE). The flares of SLE during pregnancy or after delivery are also problematic. We have previously demonstrated that nicotinamide (NAM), a non-teratogenic amide of vitamin B3, reduces inflammation and oxidative stress and improves PE-like phenotype and pregnancy outcomes in the mouse models of PE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.110DOI Listing
February 2019
1 Read

YnbB is a CdsA paralogue dedicated to biosynthesis of glycolipid MPIase involved in membrane protein integration.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate, Japan; Department of Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University, Morioka, Iwate, Japan. Electronic address:

MPIase is a glycolipid involved in protein integration in E. coli. Recently, we identified CdsA, a CDP-diacylglycerol (CDP-DAG) synthase, as a biosynthetic enzyme for MPIase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.145DOI Listing
February 2019

LncRNA FIRRE is activated by MYC and promotes the development of diffuse large B-cell lymphoma via Wnt/β-catenin signaling pathway.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Department of Hematology, The Affiliated Hospital of Qingdao University, No.16, Jiangsu Road, Qingdao, Shandong, 266003, China. Electronic address:

Diffuse large B-cell lymphoma (DLBCL) contributes to the cancer-related mortality. Increasing evidence have reported the crucial role of long non-coding RNAs (lncRNAs) in tumorigenesis. Microarray analysis was used to screen out the differentially expressed lncRNAs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.105DOI Listing
February 2019
1 Read

Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE mice via miR-let7 mediated infiltration and polarization of M2 macrophage.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurosurgery, Qilu Hospital of Shandong University, 107#, Wenhua Xi Road, Jinan, Shandong Province, 250012, PR China; Institute of Brain and Brain-Inspired Science, Shandong Provincial Key Laboratory of Brain Function Remodeling, Shandong University, Jinan, Shandong Province, PR China. Electronic address:

Atherosclerosis is a chronic inflammatory disease of the vasculature. Exosomes derived from mesenchymal stem cells (MSCs) exert immunomodulatory and immunosuppressive effects; however, the MSCs-exosomes administration on atherosclerosis was unknown. Here, our ApoE mice were fed a high-fat diet and received intravenous injections of exosomes from MSCs for 12 weeks. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X193018
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2019.02.005DOI Listing
February 2019
2 Reads

Transcriptomic analyses of oncogenic hepatocytes reveal common and different molecular pathways of hepatocarcinogenesis in different developmental stages and genders in kras transgenic zebrafish.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Department of Biological Sciences, National University of Singapore, Singapore. Electronic address:

Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is mainly due to genetic changes in hepatocytes. However, molecular expression in hepatocytes during hepatocarcinogenesis has not been characterized. In this study, using an inducible kras transgenic zebrafish models for HCC, transcriptomic profiles of oncogenic hepatocytes from larvae, male and female adult fish following a brief induction of oncogenic kras were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.008DOI Listing
February 2019
1 Read

Crystal structure and biochemical studies of the bifunctional DNA primase-polymerase from phage NrS-1.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China. Electronic address:

A novel DNA polymerase found in the deep-sea vent phage NrS-1, was confirmed to have both DNA polymerase and primase activities. In this polymerase, the N-terminal residues 1-300 (referred to as N300) are the core region required for polymerizing DNA and catalyzing de novo DNA synthesis. Here, the crystal structure of N300 was solved at a resolution of 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.144DOI Listing
February 2019

Crystal structure of AlpK: An essential monooxygenase involved in the biosynthesis of kinamycin.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, School of Medicine, Sun Yat-sen University, Guangzhou, China. Electronic address:

AlpK is an essential monooxygenase involved in the biosynthesis of kinamycin. It catalyzes the C5-hyfroxylattion of the crucial benzo[b]-fluorence intermediate in kinamycin synthesis. However, the structure and mechanism of AlpK is unclear. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X193009
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2019.01.077DOI Listing
February 2019
7 Reads

Nucleocytoplasmic shuttling of SAMHD1 is important for LINE-1 suppression.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin, 130061, China. Electronic address:

Currently, SAMHD1 is the only known dNTPase in human cells. It also suppresses the replication of both retroviruses and retroelements. SAMHD1 contains a classic nuclear localization sequence (NLS) and resides in the nucleus in live or fixed cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.02.009DOI Listing
February 2019

Evidence for in vivo interactions between dehydrins and the aquaporin AtPIP2B.

Biochem Biophys Res Commun 2019 Feb 6. Epub 2019 Feb 6.

Laboratorio de Biología Molecular de Hongos y Plantas, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica AC, San Luis Potosí, SLP, Mexico. Electronic address:

Plants have developed mechanisms that allow them to tolerate different abiotic stresses. Among these mechanisms, the accumulation of specific proteins such as dehydrins (DHNs) and aquaporins (AQPs) can protect other proteins from damage during dehydration and may allow the control of water loss, respectively. Although both types of proteins are involved in plant protection against dehydration stress, a direct interaction between them has not been explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.095DOI Listing
February 2019

The effect of CTCF binding sites destruction by CRISPR/Cas9 on transcription of metallothionein gene family in liver hepatocellular carcinoma.

Biochem Biophys Res Commun 2019 Feb 6. Epub 2019 Feb 6.

Department of Oncology, Yantai Yuhuangding Hospital, Yantai, Shandong, 264001, China. Electronic address:

Chromatin spatial organization is essential for transcriptional modulation and stabilization. The pattern of DNA distal interplay form the multiple topological associating domains (TADs), and further assemble the functional compartmentalization with open and expression-active chromatin ("A" compartments) or closed and expression-inactive chromatin ("B" compartments) in genome, whose boundaries were defined by the high enrichment of CCCTC-binding factor (CTCF). Nevertheless, As a potential therapeutic strategy, changing the local chromatin architecture via adding or removing the CTCF binding sites in situ to regulate the transcription activity of genes within one TAD in cancer cells is poorly explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.107DOI Listing
February 2019

DDX10 overexpression predicts worse prognosis in osteosarcoma and its deletion prohibits cell activities modulated by MAPK pathway.

Biochem Biophys Res Commun 2019 Feb 6. Epub 2019 Feb 6.

Department of Orthopaedics, Hospital of Zhengzhou University, Zhengzhou, 450052, PR China. Electronic address:

Osteosarcoma (OS) is an invasive cancer in the skeletal system. The molecular mechanism of its etiology and pathogenesis are still not clear, so the effective treatment strategy of OS needs further research. First, we analyzed the expression level and prognostic ability of the RNA helicase DDX10 in OS patients based on the data obtained from GEO database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.114DOI Listing
February 2019

Upregulated circular RNA circ_0074027 promotes glioblastoma cell growth and invasion by regulating miR-518a-5p/IL17RD signaling pathway.

Biochem Biophys Res Commun 2019 Feb 6. Epub 2019 Feb 6.

Department of Immunology, Qiqihar Medical University, Qiqihar, 161006, China.

Glioblastoma (GBM) is one of the major cause of the cancer-related fatality worldwide. Several circular RNAs (circRNAs) have been observed to exert functions in GBM. The current study is aimed to explore the potential mechanism of circ_0074027 via miR-518a-5p and IL17RD in GBM progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.140DOI Listing
February 2019