- Kiyoko Yamamoto,
- Takahiro Kuragano,
- Tomoko Kimura,
- Masayoshi Nanami,
- Yukiko Hasuike,
- Takeshi Nakanishi
Biochem Biophys Res Commun 2017 Nov 17. Epub 2017 Nov 17.
Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, 663-8501, Japan.
Conflicting evidence concerning leptin, an adipocyte-derived hormone, in atherogenesis and non-alcoholic fatty liver disease (NAFLD) has been reported. Iron metabolism and iron-mediated oxidative stress should be taken into consideration for the clarification of the pathogenesis of these diseases. In this study, we demonstrate that leptin receptor activation directly affects iron metabolism by the finding that serum levels of hepcidin, the master regulator of iron in the whole body, were significantly lower in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Read More