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    82854 results match your criteria Biochemical and biophysical research communications[Journal]

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    Interplay of adipocyte and hepatocyte: Leptin upregulates hepcidin.
    Biochem Biophys Res Commun 2017 Nov 17. Epub 2017 Nov 17.
    Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, 663-8501, Japan.
    Conflicting evidence concerning leptin, an adipocyte-derived hormone, in atherogenesis and non-alcoholic fatty liver disease (NAFLD) has been reported. Iron metabolism and iron-mediated oxidative stress should be taken into consideration for the clarification of the pathogenesis of these diseases. In this study, we demonstrate that leptin receptor activation directly affects iron metabolism by the finding that serum levels of hepcidin, the master regulator of iron in the whole body, were significantly lower in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Read More

    FABP4 induces asthmatic airway epithelial barrier dysfunction via ROS-activated FoxM1.
    Biochem Biophys Res Commun 2017 Nov 17. Epub 2017 Nov 17.
    Department of Respiratory and Critical Care Medicine, Chronic Airways Diseases Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:
    Functional abnormal airway epithelial cells, along with activated inflammatory cells, resulting in chronic airway inflammation, are considered as the characteristic of asthma. Fatty Acid Binding Protein 4 (FABP4) takes part in glucose and lipid homeostasis, and also have an important role in allergic airway inflammation. However, whether FABP4 influence barrier function of airway epithelial cells is unknown. Read More

    PFN2a, a new partner of RARα in the cytoplasm.
    Biochem Biophys Res Commun 2017 Nov 17. Epub 2017 Nov 17.
    IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), INSERM, U596, CNRS, UMR7104, Université de Strasbourg, 1 Rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France. Electronic address:
    Retinoic acid receptors (RARs) are classically considered as nuclear ligand-dependent regulators of transcription. Here we highlighted a novel face of the RARα subtype: RARα is present in low amounts in the cytoplasm of mouse embryonic fibroblasts (MEFs) where it interacts with profilin2a (PFN2A), a small actin-binding protein involved in filaments polymerisation. The interaction involves the N-terminal proline-rich motif (PRM) of RARα and the SH3-like domain of PFN2a. Read More

    Generation of branching ureteric bud tissues from human pluripotent stem cells.
    Biochem Biophys Res Commun 2017 Nov 17. Epub 2017 Nov 17.
    Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:
    Recent progress in kidney regeneration research is noteworthy. However, the selective and robust differentiation of the ureteric bud (UB), an embryonic renal progenitor, from human pluripotent stem cells (hPSCs) remains to be established. The present study aimed to establish a robust induction method for branching UB tissue from hPSCs towards the creation of renal disease models. Read More

    Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction.
    Biochem Biophys Res Commun 2017 Nov 17. Epub 2017 Nov 17.
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address:
    The coronary vascular system is critical for myocardial growth and cardiomyocyte survival. However, the molecular mechanism regulating coronary angiogenesis remains elusive. Vascular endothelial growth factor (VEGF) regulates angiogenesis by binding to the specific receptors Flk1 and Flt1, which results in different functions. Read More

    UNC-5 netrin receptor B mediates osteogenic differentiation by modulating bone morphogenetic protein signaling in human adipose-derived stem cells.
    Biochem Biophys Res Commun 2017 Nov 17. Epub 2017 Nov 17.
    Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China; National Engineering Lab for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing 100081, China. Electronic address:
    UNC-5 netrin receptor B (UNC5B) is a dependence receptor of netrin-1 that plays an essential role in mediating angiogenesis and tumorigenesis. Despite its significant roles, there is limited knowledge about the role played by UNC5B in osteogenesis. In the present study, we first demonstrated that UNC5B was required for osteogenic differentiation of human adipose-derived stem cells (hASCs), both in vitro and in vivo. Read More

    The role of N-terminal segment and membrane association in MyD88-mediated signaling.
    Biochem Biophys Res Commun 2017 Nov 16. Epub 2017 Nov 16.
    Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, SI-1000, Slovenia; EN-FIST Centre of Excellence, Ljubljana, SI-1000, Slovenia. Electronic address:
    MyD88 is a central signaling mediator of innate immunity, composed of the N-terminal death (DD) and C-terminal Toll/interleukin-1 receptor (TIR) domain linked by an intermediary (INT) domain. We showed that the N-terminal domain (NTD), composed of apparently unstructured 21 amino-acid residues, is involved in localization and clustering of MyD88 and is required for the efficient signaling, since the deletion mutant is unable to reconstitute MyD88-dependent signaling. Furthermore, we found that the NTD peptide interacts with phosphatidic acid, which potentiates MyD88-mediated signaling through TLRs. Read More

    Cell membrane dynamics induction using optogenetic tools.
    Biochem Biophys Res Commun 2017 Nov 16. Epub 2017 Nov 16.
    Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. Electronic address:
    Structures arising from actin-based cell membrane movements, including ruffles, lamellipodia, and filopodia, play important roles in a broad spectrum of cellular functions, such as cell motility, axon guidance in neurons, wound healing, and micropinocytosis. Previous studies investigating these cell membrane dynamics often relied on pharmacological inhibition, RNA interference, and constitutive active/dominant negative protein expression systems. However, such studies did not allow the modulation of protein activity at specific regions of cells, tissues, and organs in animals with high spatial and temporal precision. Read More

    MicroRNA let-7f-5p regulates neuronal differentiation of rat bone marrow mesenchymal stem cells by targeting Par6α.
    Biochem Biophys Res Commun 2017 Nov 16. Epub 2017 Nov 16.
    Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 1st Jianshe Street, Zhengzhou, Henan, China. Electronic address:
    Par6α (partitioning defective 6 homologue alpha), a component of the Par3/Par6/aPKC complex, was recently shown to be essential for axon specification during neuronal development. However, the biological functions and regulatory mechanisms of Par6α in the mesenchymal stem cell (MSC) differentiation process have not been investigated. In this study, we found that the expression of let-7f-5p was downregulated during differentiation of bone marrow-derived MSCs to neuron-like cells. Read More

    Induction of immune-related gene expression by seminal exosomes in the porcine endometrium.
    Biochem Biophys Res Commun 2017 Nov 16. Epub 2017 Nov 16.
    Animal Resource Science Center, Graduate School of Agricultural and Life Science, The University of Tokyo, Kasama, Ibaraki 319-2606, Japan. Electronic address:
    Seminal plasma (SP) is considered as a vehicle to carry sperm into female reproductive tract, of which functions have not been completely understood. This study aimed to identify the function of seminal exosomes on porcine endometrium. Exosomes were isolated from the sperm-rich fraction of boar semen and were confirmed by the expression of exosome marker HSP70 and size distribution using nano-sight tracking analysis. Read More

    Co-treatment with a C1B5 peptide of protein kinase Cγ and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation.
    Biochem Biophys Res Commun 2017 Nov 16. Epub 2017 Nov 16.
    Departments of Anatomy & Physiology, Kansas State University College of Veterinary Medicine, Manhattan, KS, 66506, USA. Electronic address:
    Although gemcitabine is an effective chemotherapeutic for pancreatic cancer, severe side effects often accompany its use. Since we have discovered that locally administered C1B domain peptides effectively control tumor growth without any side effects, the efficacy of co-treatment with this peptide and a low dose of gemcitabine on the growth of pancreatic cancer was examined. Two- and three-dimensional cell culture studies clarified that a co-treatment with C1B5 peptide and gemcitabine significantly attenuated growth of PAN02 mouse and PANC-1 human pancreatic cancer cells in 2D and 3D cultures. Read More

    Toward understanding barnacle cementing by characterization of one cement protein-100kDa in Amphibalanus amphitrite.
    Biochem Biophys Res Commun 2017 Nov 16. Epub 2017 Nov 16.
    Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China. Electronic address:
    Barnacles, as major fouling organisms, have attracted more attentions. It is no doubt that the study on cement proteins is required to illustrate the mechanism of barnacle cementing. A cement protein defined as Aa-cp100k was characterized from Amphibalanus amphitrite in this study. Read More

    Structural and biophysical characterization of Rv3716c, a hypothetical protein from Mycobacterium tuberculosis.
    Biochem Biophys Res Commun 2017 Nov 15. Epub 2017 Nov 15.
    National Institute for Research in Tuberculosis, Chennai 600031, India.
    Latent tuberculosis (TB) is the main hurdle in reaching the goal of "Stop TB 2050". Tuberculin skin and Interferon-gamma release assay tests used currently for the diagnosis of TB infection cannot distinguish between active disease and latent tuberculosis infection (LTBI) and hence new and sensitive protein markers need to be identified for the diagnosis. A protein Rv3716c from Mycobacterium tuberculosis (MtbRv3716c) has been identified as a potential surrogate marker for the diagnosis of LTBI. Read More

    The rice CONSTANS-like protein OsCOL15 suppresses flowering by promoting Ghd7 and repressing RID1.
    Biochem Biophys Res Commun 2017 Nov 15. Epub 2017 Nov 15.
    Zhejiang Key Laboratory of Super Rice Research and State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou 310006, PR China. Electronic address:
    The photoperiodic flowering pathway is one of the most important regulatory networks controlling flowering time in rice (Oryza sativa L.). Rice is a facultative short-day (SD) plant; flowering is promoted under inductive SD conditions and delayed under non-inductive long-day (LD) conditions. Read More

    Exosomes derived from human umbilical vein endothelial cells promote neural stem cell expansion while maintain their stemness in culture.
    Biochem Biophys Res Commun 2017 Nov 15. Epub 2017 Nov 15.
    Department of Medical Genetics and Developmental Biology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; Department of Biochemistry and Molecular Biology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:
    The neural stem cell (NSC) niche in subventricular zone (SVZ) of adult mammalian brain contains dense vascular plexus, where endothelial cells (ECs) regulate NSCs by releasing plenty of angiocrine factors. However, the role of ECs-derived exosomes, a novel type of mediators of intercellular communications, in the regulation of NSCs remains unclear. In the current study, primary NSCs isolated from embryonic mouse brains form more neurospheres when cultured in the presence of human umbilical vein endothelial cells (HUVECs). Read More

    A role for Candida albicans superoxide dismutase enzymes in glucose signaling.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address:
    The Saccharomyces cerevisiae and Candida albicans yeasts have evolved to differentially use glucose for fermentation versus respiration. S. cerevisiae is Crabtree positive, where glucose represses respiration and promotes fermentation, while the opportunistic fungal pathogen C. Read More

    Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address:
    Protein arginine methyltransferase 5 (PRMT5) is the most promising anticancer target in PRMT family. In this study, based on the first S-adenosylmethionine (SAM) competitive small molecule inhibitor (17, compound number is from original paper) of PRMT5 reported in our recent paper, we determined the molecular mechanism of 17 interacting with PRMT5 by computational methods. Previously reported CMP5 was also thought of as a SAM competitive inhibitor of PRMT5, but the direct inhibition activity against PRMT5 at enzymatic level was not provided. Read More

    Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, FL, USA; Vascular Biology Institute, University of Miami, School of Medicine, Miami, FL, USA. Electronic address:
    Secretogranin III (Scg3) was recently discovered as the first highly diabetic retinopathy-associated angiogenic factor, and its neutralizing antibody alleviated the disease with high efficacy in diabetic mice. Investigation of its molecular mechanisms will facilitate the translation of this novel therapy. Scg3 was reported to induce the phosphorylation of mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK). Read More

    W9 peptide enhanced osteogenic differentiation of human adipose-derived stem cells.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    Department of Pharmacology, Faculty of Medicine, Osaka Medical College, Osaka, Japan.
    W9 is a peptide that abrogates osteoclast differentiation via blockade of nuclear factor-κB ligand (RANKL)-RANK signaling, which activates bone formation. However, W9 stimulated osteogenesis in osteoblasts and mesenchymal stem cells. The present study demonstrated that the W9 peptide promoted osteogenic differentiation of human adipose-derived stem cells (hAdSCs) even under non-osteogenic differentiation culture conditions. Read More

    The SCF ubiquitin ligase Slimb controls Nerfin-1 turnover in Drosophila.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    The State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address:
    The C2H2 type zinc-finger transcription factor Nerfin-1 expresses dominantly in Drosophila nervous system and plays an important role in early axon guidance decisions and preventing neurons dedifferentiation. Recently, increasing reports indicated that INSM1 (homologue to nerfin-1 in mammals) is a useful marker for prognosis of neuroendocrine tumors. The dynamic expression of Nerfin-1 is regulated post-transcriptionally by multiple microRNAs; however, its post-translational regulation is still unclear. Read More

    Newly developed selective immunoinactivation assay revealed reduction in adipose triglyceride lipase activity in peripheral leucocytes from patients with idiopathic triglyceride deposit cardiomyovasculopathy.
    Biochem Biophys Res Commun 2017 Nov 13. Epub 2017 Nov 13.
    Laboratory of Cardiovascular Disease, Novel, Non-invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, 6-2-3, Furuedai, Suita, Osaka 565-0874, Japan. Electronic address:
    Triglyceride deposit cardiomyovasculopathy (TGCV) is a rare and newly identified disease among patients requiring cardiac transplantation. TGCV is characterized by cardiomyocyte steatosis and triglyceride (TG)-deposit atherosclerosis, resulting from the abnormal intracellular metabolism of TG. TGCV is classified into primary and idiopathic types. Read More

    Oxidized low-density lipoprotein promotes osteoclast differentiation from CD68 positive mononuclear cells by regulating HMGB1 release.
    Biochem Biophys Res Commun 2017 Nov 13. Epub 2017 Nov 13.
    Department of Rheumatology, Jining First People's Hospital, Jining, Shandong 272001, PR China.
    Patients with ankylosing spondylitis (AS) have an increased risk for cardiovascular mortality. The circulating ox-LDL/LDL ratio is associated with subclinical atherosclerosis in patients with systemic lupus erythematosus. In this study, we found that the ox-LDL/LDL ratio was increased in AS patients. Read More

    Old drug new tricks: Chlorhexidine acts as a potential allosteric inhibitor toward PAK1.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    Department of Surgical Oncology and General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China. Electronic address:
    This paper describes the identification of chlorhexidine, an agent commonly used in clinical as a novel potential allosteric inhibitor of PAK1. In cellular assays, chlorhexidine showed a good inhibitory profile, and its inhibitory profile was even better than IPA-3, a well-known allosteric inhibitor. In pharmacology experiments, chlorhexidine successfully inhibited the relief of PAK1 dimer and inhibited the activation of PAK1. Read More

    LOX-related collagen crosslink changes act as an initiator of bone fragility in a ZDF rats model.
    Biochem Biophys Res Commun 2017 Nov 13. Epub 2017 Nov 13.
    The State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Sichuan, People's Republic of China. Electronic address:
    Diabetes mellitus type 2 (DM2) results in bone abnormalities that manifest as increased bone fragility. Bone consists of two phases, the mineral phase and the matrix phase, and disorders in both are seen in DM2. However, the phase in which DM2 mediated bone fragility is initiated is still unknown. Read More

    Human soluble thrombomodulin-induced blockade of peripheral HMGB1-dependent allodynia in mice requires both the lectin-like and EGF-like domains.
    Biochem Biophys Res Commun 2017 Nov 13. Epub 2017 Nov 13.
    Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (formerly known as Kinki University), 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan. Electronic address:
    Thrombomodulin (TM), an endothelial protein with anti-coagulant activity, is composed of 5 domains, D1-D5. Recombinant human soluble TM (TMα) consisting of D1-D3, which is generated in CHO cells, suppresses inflammatory and nociceptive signals by inactivating high mobility group box 1 (HMGB1), one of damage-associated molecular patterns. TMα sequesters HMGB1 with the lectin-like D1 and promotes its degradation by thrombin binding to the EGF-like D2. Read More

    Biomarker identification for statin sensitivity of cancer cell lines.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    Department of Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:
    Statins are potent cholesterol reducing drugs that have been shown to reduce tumor cell proliferation in vitro and tumor growth in animal models. Moreover, retrospective human cohort studies demonstrated decreased cancer-specific mortality in patients taking statins. We previously implicated membrane E-cadherin expression as both a marker and mechanism for resistance to atorvastatin-mediated growth suppression of cancer cells; however, a transcriptome-profile-based biomarker signature for statin sensitivity has not yet been reported. Read More

    Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan; Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan. Electronic address:
    Cancer cells rapidly consume glutamine as a carbon and nitrogen source to support proliferation, but the cell number continues to increase exponentially after glutamine is nearly depleted from the medium. In contrast, cell proliferation rates are strongly depressed when cells are cultured in glutamine-free medium. How cancer cells survive in response to nutrient limitation and cellular stress remains poorly understood. Read More

    D Rhamnose β-hederin inhibits migration and invasion of human breast cancer cell line MDA-MB-231.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China. Electronic address:
    Many natural products have been shown to have inhibitory effects on the metastatic process of various cancers including breast cancer. An active triterpenoid saponin D Rhamnose β-hederin (DRβ-H) from Clematis ganpiniana, has been known induce the apoptosis of breast cancer cells, but the effect of DRβ-H on the metastasis of breast cancer cells is largely unknown. In this study, we demonstrated that a non-cytotoxic concentration of DRβ-H markedly suppressed wound healing migration, migration through the chamber and invasion through the matrigel. Read More

    Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2.
    Biochem Biophys Res Commun 2017 Nov 14. Epub 2017 Nov 14.
    KS-215, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400085, India. Electronic address:
    Previous reports show that the desmosomal plaque protein plakophilin3 (PKP3) is essential for desmosome formation. Here, we report that PKP3 over-expression decreases calcium dependency for de novo desmosome formation and makes existing cell-cell adhesion junctions more resilient in low calcium medium due to an increase in desmocollin2 expression. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins. Read More

    Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise α2,6 sialic acid-dependent and -independent interactions.
    Biochem Biophys Res Commun 2017 Nov 13. Epub 2017 Nov 13.
    Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. Electronic address:
    Lectins expressed on the cell surface are often bound and regulated by the membrane molecules containing the glycan ligands on the same cell (cis-ligands). However, molecular nature and function of cis-ligands are generally poorly understood partly because of weak interaction between lectins and glycan ligands. Cis-ligands are most extensively studied in CD22 (also known as Siglec-2), an inhibitory B lymphocyte receptor specifically recognizing α2,6 sialic acids. Read More

    Degree of pectin methyl esterification in endosperm cell walls is involved in embryo bending in Arabidopsis thaliana.
    Biochem Biophys Res Commun 2017 Nov 12. Epub 2017 Nov 12.
    Instituto de Ecología, Universidad Nacional Autónoma de México, Ciudad Universitaria, CP.04510, CDMX, Mexico. Electronic address:
    The endosperm is a transitory structure involved in proper embryo elongation. The cell walls of mature seed endosperm are generally composed of a uniform distribution of cellulose, unesterified homogalacturonans, and arabinans. Recent studies suggest that changes in cell wall properties during endosperm development could be related to embryo growth. Read More

    Long-range stress transmission guides endothelial gap formation.
    Biochem Biophys Res Commun 2017 Nov 11. Epub 2017 Nov 11.
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
    In endothelial gap formation, local tractions exerted by the cell upon its basal adhesions are thought to exceed balancing tensile stresses exerted across the cell-cell junction, thus causing the junction to rupture. To test this idea, we mapped evolving tractions, intercellular stresses, and corresponding growth of paracellular gaps in response to agonist challenge. Contrary to expectation, we found little to no relationship between local tensile stresses and gap formation. Read More

    The effect of surface charge on the thermal stability and ice recrystallization inhibition activity of antifreeze protein III (AFP III).
    Biochem Biophys Res Commun 2017 Nov 11. Epub 2017 Nov 11.
    School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK. Electronic address:
    The aim of this study was to examine the effect of chemical cationization on the structure and function of antifreeze protein III (AFP III) over an extreme temperature range (-40 °C to +90 °C) using far-UV synchrotron radiation circular dichroism (SRCD) and ice recrystallization inhibition (IRI) assays. Chemical cationization was able to produce a modified AFP III with a net cationic charge at physiological pH that had enhanced resistance to denaturation at elevated temperatures, with no immediate negative impact on protein structure at subzero temperatures. Furthermore, cationized AFP III retained an IRI activity similar to that of native AFP III. Read More

    Recombinant human GLP-1(rhGLP-1) alleviating renal tubulointestitial injury in diabetic STZ-induced rats.
    Biochem Biophys Res Commun 2017 Nov 12. Epub 2017 Nov 12.
    Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, PR China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, PR China. Electronic address:
    GLP-1-based treatment improves glycemia through stimulation of insulin secretion and inhibition of glucagon secretion. Recently, more and more findings showed that GLP-1 could also protect kidney from diabetic nephropathy. Most of these studies focused on glomeruli, but the effect of GLP-1 on tubulointerstitial and tubule is not clear yet. Read More

    Transcriptional regulation of acetoacetyl-CoA synthetase by Sp1 in neuroblastoma cells.
    Biochem Biophys Res Commun 2017 Nov 11. Epub 2017 Nov 11.
    Department of Health Chemistry, Hoshi University, Shinagawa, Tokyo, 142-8501, Japan.
    Acetoacetyl-CoA synthetase (AACS) is the enzyme responsible for cholesterol and fatty acid synthesis in the cytosol. We have previously shown that AACS has an important role in normal neuronal development and that knockdown of SREBP-2, which orchestrates cholesterol synthesis, resulted in the downregulation of AACS mRNA levels. In this study, we investigated the transcriptional mechanism of AACS in Neuro-2a, neuroblastoma cells. Read More

    Adipose tissue complement factor B promotes adipocyte maturation.
    Biochem Biophys Res Commun 2017 Nov 11. Epub 2017 Nov 11.
    Section of Periodontology, Kyushu University Faculty of Dental Science, Fukuoka, Japan. Electronic address:
    Objectives: It is well-known that the complement system plays an essential role in host immunity. Observational studies have indicated that complement system-related molecules such as complement factor B (CfB) and other components are correlated with obesity and/or insulin resistance parameters. In this study, we investigated the role of adipocyte-derived CfB in adipose tissue metabolism. Read More

    Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway.
    Biochem Biophys Res Commun 2017 Nov 11. Epub 2017 Nov 11.
    Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China. Electronic address:
    Interstitial cystitis (IC) is a bladder syndrome characterized by pelvic pain and urinary frequency without infection or other identifiable pathology. There are no effective treatments to cure IC. This study investigated the effects of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) injection on IC rat model. Read More

    Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG.
    Biochem Biophys Res Commun 2017 Nov 12. Epub 2017 Nov 12.
    Centre de Biophysique Moléculaire, CNRS UPR 4301, Affiliated with the Université d'Orléans - Pôle Universitaire Centre Val de Loire, Rue Charles Sadron, 45071 Orléans Cedex 2, France. Electronic address:
    GALIG, an internal gene to the human galectin-3 gene, encodes two distinct proteins, Mitogaligin and Cytogaligin through translation of a unique mRNA in two overlapping alternative reading frames. When overexpressed GALIG induces apoptosis. In cultured cells, Mitogaligin destabilizes mitochondria membranes through interaction with cardiolipin. Read More

    Acute and chronic cadmium telluride quantum dots-exposed human bronchial epithelial cells: The effects of particle sizes on their cytotoxicity and carcinogenicity.
    Biochem Biophys Res Commun 2017 Nov 11. Epub 2017 Nov 11.
    Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong 515041, People's Republic of China. Electronic address:
    Quantum dots (QDs) are semiconducting nanocrystals with unique optical properties. When coated with shell/capping, QDs are not deleterious to cells and organisms. However, when QDs are retained in the cellular environment for a certain period of time, their coatings may be degraded, yielding "naked" QDs. Read More

    Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation.
    Biochem Biophys Res Commun 2017 Nov 11. Epub 2017 Nov 11.
    Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan. Electronic address:
    Roundabout4 (Robo4) is an endothelial cell-specific receptor that stabilizes vasculature in pathological angiogenesis. Previous studies have shown that Robo4 is a potential therapeutic target for inflammatory diseases, but its precise roles in inflammation remain unclear. To investigate physiological Robo4 functions in inflammation, we performed a loss-of-function study in vitro and in vivo using lipopolysaccharide (LPS)-induced endotoxemia models. Read More

    Downregulation of caveolin-1 increased EGFR-TKIs sensitivity in lung adenocarcinoma cell line with EGFR mutation.
    Biochem Biophys Res Commun 2017 Nov 12. Epub 2017 Nov 12.
    Department of Immunology, Hebei Medical University, Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang 050017, Hebei, China. Electronic address:
    Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), including gefitinib and erlotinib, have shown notable effects in lung adenocarcinoma patients harboring EGFR mutations, there are significant differences between individual patients in the degree of benefits provided by EGFR-TKIs. Some evidence supports a role for caveolin-1 (Cav-1) in modulating drug sensitivity. This study aimed to investigate whether Cav-1 plays an important role in sensitivity to EGFR-TKIs in lung adenocarcinoma cells. Read More

    Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo.
    Biochem Biophys Res Commun 2017 Nov 10. Epub 2017 Nov 10.
    Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address:
    Bromodomain-containing protein 4 (BRD4) and phosphatidylinositol 3-kinase (PI3K) are both key oncogenic proteins in human prostate cancer. In the current study, we examined the anti-prostate cancer cell activity by SF2523, a BRD4 and PI3K dual inhibitor. We showed that SF2523 potently inhibited survival and proliferation of the primary human prostate cancer cells. Read More

    Expression of FSHR in chondrocytes and the effect of FSH on chondrocytes.
    Biochem Biophys Res Commun 2017 Nov 10. Epub 2017 Nov 10.
    Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong province, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong province, China; Scientific Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong province, China. Electronic address:
    Objective: Chondrocytes express many kinds of hormone receptors. The function of Follicle stimulating hormone (FSH) in the ovary is mediated by FSH receptor (FSHR). FSH receptor (FSHR) is found in many non-ovarian tissues, however it has been unclear if chondrocytes express FSHR. Read More

    Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice.
    Biochem Biophys Res Commun 2017 Nov 11. Epub 2017 Nov 11.
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. Electronic address:
    Normal bone mineralization requires phosphate oversaturation in bone matrix vesicles, as well as normal regulation of phosphate metabolism via the interplay among bone, intestine, and kidney. In turn, derangement of phosphate metabolism greatly affects bone function and structure. The type III sodium-dependent phosphate transporters, PiT-1 and PiT-2, are believed to be important in tissue phosphate metabolism and physiological bone formation, but their requirement and molecular roles in bone remain poorly investigated. Read More

    Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3β pathway in cells and in APP/PS1 transgenic mice.
    Biochem Biophys Res Commun 2017 Nov 9. Epub 2017 Nov 9.
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Institute for Brain Disorders, Beijing Engineering Research Center for Nerve System Drugs, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China. Electronic address:
    Alternative splicing of amyloid precursor protein (APP) exon 7 generates the isoforms containing a Kunitz protease inhibitor (KPI) domain. APP-KPI levels in the brain are correlated with amyloid beta (Aβ) production. Here, we determined the effect of Tetrahydroxystilbene glucoside (TSG) on the AKT-GSK3β pathway. Read More

    Mitochondrial tRNA(Thr) 15909A>G mutation associated with hypertension in a Chinese Han pedigree.
    Biochem Biophys Res Commun 2017 Nov 10. Epub 2017 Nov 10.
    Attardi Institute of Mitochondrial Biomedicine, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address:
    Mitochondrial DNA mutations are one of the molecular genetic bases of hypertension. Here, we performed clinical, genetic and mutational evaluation, molecular characterization as well as biochemical analysis of a Chinese Han family with maternally inherited hypertension. The m. Read More

    FOXJ1 promotes bladder cancer cell growth and regulates Warburg effect.
    Biochem Biophys Res Commun 2017 Nov 9. Epub 2017 Nov 9.
    Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. Electronic address:
    Forkhead Box J1 (FOXJ1) which belongs to Fox gene family, plays complex and crucial roles in processes of development, organogenesis, regulation of the immune system, as well as progression of several malignancies. However, how FOXJ1 functions in bladder cancer remains unclear. Here, we report that FOXJ1 is upregulated in most bladder cancer patients, and predicts poor clinical outcomes. Read More

    PRMT1 mediates podocyte injury and glomerular fibrosis through phosphorylation of ERK pathway.
    Biochem Biophys Res Commun 2017 Nov 10. Epub 2017 Nov 10.
    Tongji University School of Medicine (First Unit), Department of Nephrology, Shanghai East Hospital (Second Unit), Shanghai, China. Electronic address:
    Diabetic nephropathy (DN) is characterized by a change of glomerular structure and dysfunction of filtration barrier, which significantly accompanied by podocytes apoptosis and glomerular fibrosis. Angiotensin Ⅱ(Ang Ⅱ) induced activation of ERK1/2 signaling plays important roles in causing apoptosis of podocytes in DN kidneys. Previous studies have shown that PRMT1 have a pro-inflammatory function through activating ERK1/2 signaling pathway during development of chronic pulmonary disease, however, its role in DN development has not been investigated. Read More

    RecBCD (Exonuclease V) is inhibited by DNA adducts produced by cisplatin and ultraviolet light.
    Biochem Biophys Res Commun 2017 Nov 10. Epub 2017 Nov 10.
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:
    The presence of adducts on the DNA double-helix can have major consequences for the efficient functioning of DNA repair enzymes. E. coli RecBCD (exonuclease V) is involved in recombinational repair of double-strand breaks that are caused by defective DNA replication, DNA damaging agents and other factors. Read More

    Monoterpenoid perillyl alcohol impairs metabolic flexibility of Candida albicans by inhibiting glyoxylate cycle.
    Biochem Biophys Res Commun 2017 Nov 9. Epub 2017 Nov 9.
    Amity Institute of Biotechnology, Amity University Haryana, Gurugram (Manesar) 122413, India. Electronic address:
    The metabolic pathway such as glyoxylate cycle (GC) enables Candida albicans, to survive under glucose deficient conditions prevalent in the hostile niche. Thus its key enzymes (Isocitrate lyase; ICL and malate synthase; MLS) represent attractive targets against C. albicans. Read More

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