374,186 results match your criteria Biochemical Society Transactions[Journal]


Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA. ALKBH3 can promote cancer cell proliferation, migration and invasion. Read More

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December 2018

Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, P.R. China.

Human NOL1/NOP2/Sun RNA methyltransferase family member 6 (hNSun6) generates 5-methylcytosine (m5C) at C72 of four specific tRNAs, and its homologs are present only in higher eukaryotes and hyperthermophilic archaea. Archaeal NSun6 homologs possess conserved catalytic residues, but have distinct differences in their RNA recognition motifs from eukaryotic NSun6s. Until now, the biochemical properties and functions of archaeal NSun6 homologs were unknown. Read More

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December 2018
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Dietary total antioxidant capacity (TAC) among candidates for coronary artery bypass grafting (CABG) surgery: Emphasis to possible beneficial role of TAC on serum vitamin D.

PLoS One 2018 12;13(12):e0208806. Epub 2018 Dec 12.

Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Aims: Recently, the clinical importance of total antioxidant capacity (TAC) and its protective role against several chronic diseases like cardiovascular disease, osteoporosis and several types of cancers has been reported. However, its association with cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet. CABG is associated with increased oxidative stress and free radicals; so, the current study was aimed to evaluate the potential association of TAC with cardiovascular risk factors among patients candidate for CABG. Read More

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December 2018
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Physicochemical and microbiological characterization of the sensory deviation responsible for the origin of the special sherry wines "palo cortado" type.

PLoS One 2018 12;13(12):e0208330. Epub 2018 Dec 12.

Department of Chemical Engineering and Food Technology, Faculty of Sciences, University of Cadiz, Cadiz, Spain.

The aim of this study was to characterize the biochemical changes and microbiological processes involved in the sensory deviation of "sobretablas" wines during biological aging, which leads to the origin of special or rare "palo cortado" wines. Industrial trials of biological aging of "sobretablas" wines with the potential for the development of lactic acid bacteria (LAB) were performed to study this phenomenon. The results showed that sensory deviation was due to the development of malolactic fermentation (MLF) together with an attenuated aerobic metabolism of "flor" yeast. Read More

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December 2018
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Desert plant bacteria reveal host influence and beneficial plant growth properties.

PLoS One 2018 12;13(12):e0208223. Epub 2018 Dec 12.

Desert Agriculture Initiative, King Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences and Engineering Division (BESE), Thuwal, Kingdom of Saudi Arabia.

Deserts, such as those found in Saudi Arabia, are one of the most hostile places for plant growth. However, desert plants are able to impact their surrounding microbial community and select beneficial microbes that promote their growth under these extreme conditions. In this study, we examined the soil, rhizosphere and endosphere bacterial communities of four native desert plants Tribulus terrestris, Zygophyllum simplex, Panicum turgidum and Euphorbia granulata from the Southwest (Jizan region), two of which were also found in the Midwest (Al Wahbah area) of Saudi Arabia. Read More

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December 2018

[Fulminating ischemic hepatitis induced by severe cardiac dysfunction: case report].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):285-288

Facultad de Medicina, Universidad Peruana Cayetano Heredia. Lima, Perú.

Ischemic Hepatitis is an uncommon entity in daily clinical practice with a prevalence of 0.16 to 0.5% among patients admitted to a critical care unit, associated with an approximate 60% mortality rate. Read More

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December 2018
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Novel Application of the Pfirrmann Disc Degeneration Grading System to 9.4T MRI: Higher Reliability Compared to 3T MRI.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, Monash Medical Centre, Clayton, Victoria, Australia.

Study Design: Reliability Study.

Objective: To evaluate the applicability and reliability of 9.4T MRI in the assessment of degenerative disc disease compared to 3T MRI. Read More

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December 2018

68Ga-PSMA PET/CT Urachus Metastases in Recurrent Prostate Cancer With Very Low PSA Level.

Clin Nucl Med 2019 Jan;44(1):40-41

Peritoneal carcinomatosis in prostate cancer is extremely rare and has been described in only few cases with high PSA level, androgen deprivation, or in symptomatic patients. To date, 2 cases of Ga-PSMA PET positive peritoneal metastases have been reported. We report a case of urachus metastases showed on Ga-PSMA PET/CT performed for biochemical recurrence with a very low PSA level at 0. Read More

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January 2019

Standards of Care for Hypoparathyroidism in Adults.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

B Clarke, Medicine, Mayo Clinic School of Medicine, Rochester, MN, USA, Rochester, United States.

Purpose: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included. Read More

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December 2018

Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4.

FASEB J 2018 Dec 12:fj201801498R. Epub 2018 Dec 12.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Peroxisomes are essential organelles for the specialized oxidation of a wide variety of fatty acids, but they are also able to degrade fatty acids that are typically handled by mitochondria. Using a combination of pharmacological inhibition and clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 genome editing technology to simultaneously manipulate peroxisomal and mitochondrial fatty acid β-oxidation (FAO) in HEK-293 cells, we identified essential players in the metabolic crosstalk between these organelles. Depletion of carnitine palmitoyltransferase (CPT)2 activity through pharmacological inhibition or knockout (KO) uncovered a significant residual peroxisomal oxidation of lauric and palmitic acid, leading to the production of peroxisomal acylcarnitine intermediates. Read More

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December 2018

Enterococci as a key parameter for water quality index: Purires River, Costa Rica.

J Water Health 2018 Dec;16(6):1007-1017

Instituto de Investigaciones en Salud (INISA), Universidad de Costa Rica, 2060, San José, Costa Rica E-mail:

This study used the Canadian Water Quality Index (CWI) to characterize water sampled at three points within the Purires River micro basin, Costa Rica. The first sampling point is located in a high zone with domestic agricultural activities, the second point around the mid-point of the flow of the river, and the third point at the lowest zone with extensive agricultural activities mainly centered on the production of fresh vegetables. Eleven physicochemical parameters (As, Cd, Cr, biochemical oxygen demand (BOD), chemical oxygen demand (COD), NH, NO, Pb, pH, percent saturation of dissolved oxygen (PSO), and total suspended solids (TSS)) and two microbiological parameters (fecal coliforms and enterococci) were evaluated. Read More

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December 2018

Class I methyltransferase VioH catalyzes unusual SAM cyclization leading to 4-methylazetidinecarboxylic acid formation in vioprolide biosynthesis.

Authors:
Fu Yan Rolf Müller

ACS Chem Biol 2018 Dec 12. Epub 2018 Dec 12.

SAM-dependent methyltransferases are intensely studied since they play important roles in the methylation of biomolecules in all domains of life. In this study we describe that the methyltransferase VioH from Cysotobacter violaceus catalyzes a so far unknown cyclization of SAM to azetidine-2-carboxylic acid (AZE), which is proposed to be the precursor of the unusual 4-methylazetidinecarboxylic acid (MAZ) moiety of vioprolides. In vitro biochemical investigations reveal that SAM is converted to AZE in the presence of VioH, while MAZ is generated by coexpression of VioH and the radical SAM enzyme VioG in Myxococcus xanthus or by combination of VioH and the cell lysate of M. Read More

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December 2018

Primary malignant tumors of the adrenal glands.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e756s. Epub 2018 Dec 10.

Unidade de Suprarrenal, Laboratorio de Hormonios e Genetica Molecular LIM/42, Servico de Endocrinologia e Metabologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Malignancy must be considered in the management of adrenal lesions, including those incidentally identified on imaging studies. Adrenocortical carcinomas (ACCs) are rare tumors with an estimated annual incidence of 0.7-2 cases per year and a worldwide prevalence of 4-12 cases per million/year. Read More

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December 2018

Detection molecular of Rangelia vitalii in dogs from Parana State, Southern Brazil.

Rev Bras Parasitol Vet 2018 Dec 10. Epub 2018 Dec 10.

Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Paraná - UFPR, Curitiba, PR, Brasil.

Rangelia vitalii infects erythrocytes, leukocytes and endothelial cells of dogs. The present study aimed to report the molecular detection confirmed by sequencing of R. vitalii in the state of Paraná, as well as describe the clinical, hematological and biochemical alterations of the infected dogs. Read More

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December 2018

CORRELATION BETWEEN NONALCOHOLIC FATTY LIVER DISEASE FEATURES AND LEVELS OF ADIPOKINES AND INFLAMMATORY CYTOKINES AMONG MORBIDLY OBESE INDIVIDUALS.

Arq Gastroenterol 2018 Jul-Sep;55(3):247-251

Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Cirurgia, Campinas, SP, Brasil.

Background: Nonalcoholic fatty liver disease (NAFLD) is the commonest hepatopathy worldwide.

Objective: To investigate the correlations between NAFLD histopathological features and the levels of adipokines (adiponectin, leptin, and resistin) and circulating inflammatory markers (interleukin-6 [IL-6], interleukin-8 [IL-8], tumor necrosis factor alpha [TNF-α], and C-reactive protein [CRP]).

Methods: This is an exploratory cross-sectional study, which enrolled 19 women with obesity who underwent bariatric surgery. Read More

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February 2018
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[Association between excess weight and serum lipid alterations in adolescents].

Cien Saude Colet 2018 Dec;23(12):4055-4063

Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas. Campinas SP Brasil.

The study estimated the prevalence of serum lipid alterations among adolescents and investigated its association with excess weight and abdominal obesity. It involved a cross-sectional study with 525 adolescents from Piracicaba (São Paulo state). Anthropometric (body mass index, waist circumference and waist-height ratio) and biochemical information were obtained (total cholesterol and fractions, triglycerides). Read More

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December 2018

VITAMIN D DEFICIENCY AND PARATOHOMMONIUM INCREASE IN LATE POSTOPERATIVE GASTRIC BYPASS IN ROUX-EN-Y.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1407. Epub 2018 Dec 6.

Lane Clinic, Campinas, SP, Brazil.

Background : Roux-en-Y gastric bypass patients can experience changes in calcium metabolism and hyperparathyroidism secondary to vitamin D deficiency.

Aim : To evaluate nutritional deficiencies related to the calcium metabolism of patients undergoing gastric bypass with a 10-year follow-up.

Method : This is a longitudinal retrospective study of patients submitted to Roux-en-Y gastric bypass at a multidisciplinary clinic located in the Brazilian southeast region. Read More

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December 2018

The protective effect of rifampicin on behavioral deficits, biochemical, and neuropathological changes in a cuprizone model of demyelination.

Cytokine 2019 Jan 24;113:417-426. Epub 2018 Oct 24.

Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Multiple sclerosis (MS) is a disease of the central nervous system (CNS) in which both neuroinflammation and neurodegeneration play critical roles in the pathogenesis of the disease. A growing body of evidence indicates that some antibiotics have anti-inflammatory and neuroprotective properties. Rifampicin, commonly used for the treatment of mycobacteria, has been shown to exert neuroprotective activities in neurodegenerative diseases. Read More

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January 2019

Terpenoid-rich Elettaria cardamomum extract prevents Alzheimer-like alterations induced in diabetic rats via inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines.

Cytokine 2019 Jan 24;113:405-416. Epub 2018 Oct 24.

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Purpose: Recent studies suggested that the non-familiar form of Alzheimer's disease (AD) could be consequence of metabolic syndrome and neuroinflammation. Elettaria cardamomum extract (EC) has exhibited antidiabetic, antioxidant and anti-inflammatory properties. This research was conducted to evaluate the effects of EC on AD-like alterations in rats induced by high fructose and high fat diet coupled with a single small dose of STZ (25 mg/kg) (T2DM rats). Read More

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January 2019

Evaluation of levels of interleukin-6, interleukin-8 and some haematologic parameters of dogs with cutaneous wounds.

Cytokine 2019 Jan 28;113:128-138. Epub 2018 Jun 28.

Department of Veterinary Medicine, ABU, Zaria, Nigeria.

The aim of the study was to investigate the time-course of serum and wound fluids interleukin (IL)-6 and IL-8 levels in dogs with cutaneous wounds and their relationship with some haematologic parameters. The experimental group comprised of six adult dogs that underwent surgery with wounds (n = 6) on the mid lateral aspect of the right antebrachium; and control group of six, apparently, healthy intact (free from cutaneous wounds) adult dogs, comprising equal number of both sexes. Vital signs evaluated were within normal limits. Read More

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January 2019

Biochemical Mechanisms and Therapeutic Strategies in Gastrointestinal and Metabolic Disorders.

Curr Pharm Des 2018 ;24(27):3153-3154

School of Health Sciences, College of Health and Medicine University of Tasmania, Launceston, Tasmania, Australia.

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January 2018

Suppressive Effects of the Standardized Extract of Phyllanthus amarus on Type II collagen-induced Rheumatoid Arthritis in Sprague Dawley Rats.

Curr Pharm Biotechnol 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine,University of Tabuk, Tabuk 71491. Saudi Arabia.

Background: Standardized extract of Phyllanthus amarus has been shown to possess inhibitory effects on cellular and humoral immune responses in Wistar-Kyoto rats and Balb/c mice.

Objective: In the present study, the standardized extract of P. amarus was investigated for its suppressive effects on type II collagen-induced rheumatoid arthritis (TCIA) in Sprague Dawley rats. Read More

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December 2018

Fundamentals of RNA Analysis on Biobanked Specimens.

Authors:
Samuel P Strom

Methods Mol Biol 2019 ;1897:345-357

Fulgent Genetics, Temple City, CA, USA.

Compared to DNA, analysis of RNA is one step closer on the central dogma of biology to assessing cellular function. This makes it an extremely valuable target for research and clinical testing in nearly all areas of molecular biology. Most RNA molecules are ephemeral by nature. Read More

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January 2019

Parameter-efficient bioclogging model: calibration and comparison with laboratory data.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

College of Harbour, Coastal and Offshore Engineering, Hohai University, Nanjing, 210098, People's Republic of China.

A parameter-efficient bioclogging model coupled with hydrodynamics was developed with a stepwise numerical calculation. Column lab tests were carried out to calibrate and verify the bioclogging model developed in this paper. The results showed that the experimental data fit well with the simulation data, which indicated that the developed model was reasonable. Read More

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December 2018

Acute triflumuron exposure induces oxidative stress responses in liver and kidney of Balb/C mice.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

Triflumuron (TFM) is one of the most widely used insecticides over the world. It is a benzoylphenyl urea that belongs to the class of insect growth regulators. This insecticide acts by inhibiting insect's chitin synthesis and by consequences, making insect more susceptible to pathogens and malformations. Read More

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December 2018

Changes in serum and intracardiac fibroblast growth factor 23 during the progression of left ventricular hypertrophy in hypertensive model rats.

Clin Exp Nephrol 2018 Dec 11. Epub 2018 Dec 11.

Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Background: Recent clinical studies have demonstrated that serum fibroblast growth factor 23 (FGF23) levels have a significant association with left ventricular hypertrophy (LVH). Although LVH is commonly seen in hypertensive patients, the association between FGF23, hypertension, and LVH remains unclear. We aimed to examine the changes in serum and intracardiac FGF23 during the progression of hypertension using spontaneously hypertensive rats (SHR). Read More

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December 2018

Anticaries effect of toothpaste with nano-sized sodium hexametaphosphate.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

School of Dentistry, Araçatuba, Department of Pediatric Dentistry and Public Health, São Paulo State University (UNESP), Rua José Bonifácio 1193, Aracatuba, SP, 16015-050, Brazil.

Objective: To evaluate the effect of a fluoride toothpaste containing nano-sized sodium hexametaphosphate (HMPnano) on enamel demineralization on the biochemical composition and insoluble extracellular polysaccharide (EPS) in biofilm formed in situ.

Methods: This crossover double-blind study consisted of four phases (7 days each), in which 12 volunteers wore intraoral appliances containing four enamel bovine blocks. The cariogenic challenge was performed using 30% sucrose solution (6×/day). Read More

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December 2018

T-cell receptor-α CDR3 domain chemical features correlate with survival rates in bladder cancer.

J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, USA.

Purpose: In certain cancer settings, a T-cell response to cancer represents a relatively favorable outcome. Thus, the near-future challenges include a better understanding of exactly which T-cell features contribute to a response to which cancer antigen-groups, to maximize the opportunities for tumor-infiltrating lymphocyte (TIL)-based therapies and other immunotherapies.

Methods: The immune receptor complementarity determining region-3 (CDR3) is considered to be important for antigen binding, hence, in this report, we evaluated the chemical features of the CDR3 of 846 T-cell receptor-α (TCR-α) coding regions associated with bladder tumor tissue, using bioinformatics databases. Read More

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December 2018

Mechanical-activated digital microfluidics with gradient surface wettability.

Lab Chip 2018 Dec 12. Epub 2018 Dec 12.

Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.

This paper reports a simple yet effective droplet manipulation approach that can displace aqueous droplets over a long distance within the working plane. Repeated patterns with surface gradient wettability were created on a super-hydrophobic surface by laser irradiation. Aqueous droplets as small as 2 μL are moved on the patterns over a long distance under in-plane symmetric cyclic vibration. Read More

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December 2018

Th1/Th2 Dichotomy in Obese Women with Gestational Diabetes and Their Macrosomic Babies.

J Diabetes Res 2018 14;2018:8474617. Epub 2018 Nov 14.

Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, 5005 Dakar-Fann, Senegal.

The aim of the study was to assess T cell differentiation and the modulation of inflammatory cytokines in obese and gestational diabetes mellitus (GDM) women and their macrosomic newborns. Hence, immediately after delivery, blood samples were collected through the mother's arm vein and the umbilical cordon vein. Biochemical parameters measured were HbA1C, glucose, insulin, triglyceride (TG), total cholesterol (Tchol), HDL cholesterol (HDLchol), and LDL cholesterol (LDLchol). Read More

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November 2018
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Unusual bilateral ureter strangulation by fibrous tissue after perineal hernia repair in a dog.

Open Vet J 2018 19;8(4):441-444. Epub 2018 Nov 19.

Hokkaido University Veterinary Teaching Hospital, Kita 19, Nishi 10, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.

A 10-year-old castrated male cross-breed dog was referred for the repair of perineal hernia with bladder retroflexion and a mass lesion in the hernial sac. Surgical treatment was performed and the mass was identified as degenerated adipose tissue that was suspected to be derived from the omentum. The hernial contents were reduced without difficulty, and the dog exhibited a normal recovery. Read More

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November 2018

subsp. , the cause of contagious caprine pleuropneumonia, comprises two distinct biochemical groups.

Open Vet J 2018 26;8(4):393-400. Epub 2018 Oct 26.

Consultant, The Oaks, Nutshell Lane, Upper Hale, Farnham, Surrey GU9 0HG, UK.

subsp. , the cause of the World Organisation of Animal Health- listed contagious caprine pleuropneumonia, is a member of the cluster which comprises five pathogenic mycoplasmas of ruminants. These mycoplasmas are closely related immunologically and genetically which can lead to difficulties for differential diagnosis. Read More

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October 2018

Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet-Induced Accumulation of Lipid in the Liver of ApoE Mice.

Oxid Med Cell Longev 2018 14;2018:6256802. Epub 2018 Nov 14.

Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, Wuhan 430023, China.

Diets containing various docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) ratios protect against liver damage in mice fed with a high-fat diet (HFD). However, it is unclear whether these beneficial roles of DHA and EPA are associated with alterations of fatty acid (FA) composition in the liver. This study evaluated the positive impacts of n-6/n-3 polyunsaturated fatty acids (PUFAs) containing different DHA/EPA ratios on HFD-induced liver disease and alterations of the hepatic FA composition. Read More

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November 2018

Groove Pancreatitis Masquerading as Pancreatic Carcinoma-Detected on F-FDG PET/CT.

Nucl Med Mol Imaging 2018 Dec 20;52(6):473-474. Epub 2018 Oct 20.

2Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Groove pancreatitis is a rare form of chronic pancreatitis that affects the groove area adjacent to the second part of the duodenum. Clinical and biochemical features often overlap with other subsets of chronic pancreatitis, while the imaging features resemble that of carcinoma of the head of pancreas. We present a 38-year-old man with abdominal pain, nausea, vomiting, and loss of weight who underwent F-FDG PET/CT to rule out a pancreatic malignancy. Read More

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December 2018

Evaluation of RECIST, PERCIST, EORTC, and MDA Criteria for Assessing Treatment Response with Ga68-PSMA PET-CT in Metastatic Prostate Cancer Patient with Biochemical Progression: a Comparative Study.

Nucl Med Mol Imaging 2018 Dec 26;52(6):420-429. Epub 2018 Sep 26.

4Department of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.

Purpose: The aim of the study was to compare response evaluation criteria in solid tumours 1.1 (RECIST 1.1), positron emission tomography response criteria in solid tumours (PERCIST), European organisation for research and treatment of cancer (EORTC), and MD Anderson (MDA) criteria for response assessment by Gallium 68-prostate-specific membrane antigen positron emission tomography-computed tomography (Ga68-PSMA PET-CT) in metastatic adenocarcinoma prostate cancer (mPCa) patients with biochemical progression. Read More

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December 2018

Cellular Complexity in MAPK Signaling in Plants: Questions and Emerging Tools to Answer Them.

Front Plant Sci 2018 27;9:1674. Epub 2018 Nov 27.

Institute of Plant Sciences Paris Saclay (IPS2), CNRS, INRA, Université Paris-Sud, Université d'Evry, Université Paris-Saclay, Gif-sur-Yvette, France.

Mitogen activated protein kinase (MAPK) cascades play an important role in many aspects of plant growth, development, and environmental response. Because of their central role in many important processes, MAPKs have been extensively studied using biochemical and genetic approaches. This work has allowed for the identification of the MAPK genes and proteins involved in a number of different signaling pathways. Read More

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November 2018

In , OatA (Formerly YjgM) Uses Acetyl-Serine and Acetyl-CoA to Synthesize Diacetylserine, Which Upregulates Cysteine Biosynthesis.

Front Microbiol 2018 27;9:2838. Epub 2018 Nov 27.

Department of Microbiology, University of Georgia, Athens, GA, United States.

L-Cysteine biosynthesis has been extensively analyzed in . The cysteine regulon contains the genes whose protein products are necessary to convert sulfate to sulfide, which is eventually reacted with -acetyl-serine (OAS) to generate cysteine. The LysR type regulator, CysB, is required for activation of the cysteine regulon, and its interaction with various genes has been thoroughly characterized. Read More

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November 2018

Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging.

Front Endocrinol (Lausanne) 2018 27;9:515. Epub 2018 Nov 27.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare commonly benign neuroendocrine tumors that share pathology features and clinical behavior in many cases. While PCCs are chromaffin-derived tumors that arise within the adrenal medulla, PGLs are neural-crest-derived tumors that originate at the extraadrenal paraganglia. Pheochromocytoma-paraganglioma (PPGL) syndromes are rapidly evolving entities in endocrinology and oncology. Read More

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November 2018

X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging.

Front Aging Neurosci 2018 27;10:394. Epub 2018 Nov 27.

Center for Magnetic Resonance Research (CMRR), Department of Radiology, School of Medicine, University of Minnesota, Minneapolis, MN, United States.

Brain relies on glucose and oxygen metabolisms to generate biochemical energy in the form of adenosine triphosphate (ATP) for supporting electrophysiological activities and neural signaling under resting or working state. Aging is associated with declined mitochondrial functionality and decreased cerebral energy metabolism, and thus, is a major risk factor in developing neurodegenerative diseases including Alzheimer's disease (AD). However, there is an unmet need in the development of novel neuroimaging tools and sensitive biomarkers for detecting abnormal energy metabolism and impaired mitochondrial function, especially in an early stage of the neurodegenerative diseases. Read More

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November 2018

Which methods are appropriate for the detection of and is it worthwhile to distinguish from ?

Infect Drug Resist 2018 21;11:2335-2344. Epub 2018 Nov 21.

Department of Medical Sciences, Clinical Microbiology, Uppsala University, Uppsala, Sweden,

Purpose: To further analyze a clinical isolate originally identified as methicillin-resistant (MRSA) using whole-genome sequencing and comparative genomics.

Materials And Methods: Classical diagnostic methods such as cultivation, biochemical tests, and PCR were supplemented with whole-genome sequencing and comparative genomics, to identify the isolate.

Results: The isolate was phenotypically similar to MRSA. Read More

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November 2018

Biogenic pentagonal silver nanoparticles for safer and more effective antibacterial therapeutics.

Int J Nanomedicine 2018 21;13:7789-7799. Epub 2018 Nov 21.

Nanomedicine & Nanobiotechnology Lab, Department of Biosciences, Integral University, Dasauli, Lucknow, India,

Background: Biological synthesis of nanomaterials possesses unprecedented potential in the production of nanomaterials due to their ability to produce nanomaterials with improved biocompatibility in addition to eco-friendly synthetic procedures.

Methods: This article reports the isolation of an air-borne fungus from the campus of Integral University, Lucknow, with an exceptional ability to withstand very high concentrations of silver salt. The fungus was found to produce pentagonal silver nanoparticles (AgPgNps) when silver ions were reduced from silver nitrate. Read More

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November 2018

Dysregulated autophagy contributes to caspase-dependent neuronal apoptosis.

Cell Death Dis 2018 Dec 11;9(12):1189. Epub 2018 Dec 11.

Department of Systems Biology, Yonsei University College of Life Science and Biotechnology, Seoul, 120-749, South Korea.

Autophagy is a regulated, intracellular degradation process that delivers unnecessary or dysfunctional cargo to the lysosome. Autophagy has been viewed as an adaptive survival response to various stresses, whereas in other cases, it promotes cell death. Therefore, both deficient and excessive autophagy may lead to cell death. Read More

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December 2018

Therapeutic effect of hepatocyte growth factor-overexpressing bone marrow-derived mesenchymal stem cells on CCl-induced hepatocirrhosis.

Cell Death Dis 2018 Dec 11;9(12):1186. Epub 2018 Dec 11.

Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.

Hepatocirrhosis is one of the most severe complications of chronic hepatic disease in terms of medical intervention, and the available therapies are limited and not very successful. In this study, bone marrow-derived mesenchymal stem cells (BM-MSCs) from host rats were transduced with an adenoviral vector labelled with green fluorescent protein (EGFP) to overexpress hepatocyte growth factor (HGF). The therapeutic effect of these modified stem cells (HGF-BM-MSC group) transplanted intravenously into hepatocirrhosis model rats treated with CCl was evaluated using serological, biochemical and histological approaches. Read More

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December 2018

Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA

produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics. Read More

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December 2018

The Protozoan Targets Bacteria with Laterally Acquired NlpC/P60 Peptidoglycan Hydrolases.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

School of Biological Sciences, University of Auckland, Auckland, New Zealand

The human eukaryotic pathogen causes trichomoniasis, a prevalent sexually transmitted infection. This extracellular protozoan is intimately associated with the human vaginal mucosa and microbiota, but key aspects of the complex interactions between the parasite and the vaginal bacteria remain elusive. We report that has acquired, by lateral gene transfer from bacteria, genes encoding peptidoglycan hydrolases of the NlpC/P60 family. Read More

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December 2018

kinesin-8 stabilizes the kinetochore-microtubule interaction.

J Cell Biol 2018 Dec 11. Epub 2018 Dec 11.

Division of Biological Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan

Kinesin-8 is required for proper chromosome alignment in a variety of animal and yeast cell types. However, it is unclear how this motor protein family controls chromosome alignment, as multiple biochemical activities, including inconsistent ones between studies, have been identified. Here, we find that kinesin-8 (Klp67A) possesses both microtubule (MT) plus end-stabilizing and -destabilizing activity, in addition to kinesin-8's commonly observed MT plus end-directed motility and tubulin-binding activity in vitro. Read More

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December 2018

Prostate Cancer Risk-Associated Single-Nucleotide Polymorphism Affects Prostate-Specific Antigen Glycosylation and Its Function.

Clin Chem 2018 Dec 11. Epub 2018 Dec 11.

Australian Prostate Cancer Research Centre-Queensland and Cancer Program, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia

Background: Genetic association studies have reported single-nucleotide polymorphisms (SNPs) at chromosome 19q13.3 to be associated with prostate cancer (PCa) risk. Recently, the rs61752561 SNP (Asp84Asn substitution) in exon 3 of the kallikrein-related peptidase 3 () gene encoding prostate-specific antigen (PSA) was reported to be strongly associated with PCa risk ( = 2. Read More

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December 2018

Frequency of Takotsubo Cardiomyopathy in Adult Patients Receiving Chemotherapy (from a 5-Year Nationwide Inpatient Study).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Cardiology, Atlanta VA Medical Center, Decatur, Georgia; Department of Cardiology, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

Takotsubo cardiomyopathy (TC) develops in patients who are under significant emotional, psychosocial, or sudden biochemical stress. However, the added burden of TC on the patients receiving chemotherapy has never been studied. We aimed to describe the additional clinical and economic burden, along with the potential predictors of TC and related in-hospital mortality in patients receiving chemotherapy using the largest inpatient cohort. Read More

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November 2018

Thermal Structure-Induced Biochemical Parameters Stratification in a Subtropical Dam Reservoir.

Water Environ Res 2018 Dec;90(12):2036-2048

Although stratification in deep lakes is well-discussed, few studies pay attention to thermal structure as well as its influences on stratification of biochemical parameters in subtropical lakes in mountainous cities. Here, we studied the depth profile of temperature and biochemical parameters in Longjing Lake, a subtropical reservoir in a mountainous city. Thermal stratification became strong during summer. Read More

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December 2018

Ageing influences the relationship of circulating miR-33a and miR- 33b levels with insulin resistance and adiposity.

Diab Vasc Dis Res 2018 Dec 11:1479164118816659. Epub 2018 Dec 11.

1 Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.

Objective:: The identification of circulating microRNAs related to abnormal metabolic function may be useful in the context of ageing, adiposity and insulin resistance. The miR-33 a/b has been shown to control the expression of genes involved in fatty acid biosynthesis, impaired metabolism and insulin resistance. In this study, we aimed to identify differences in circulating miR-33 a/b levels according to age-related metabolic impairment and increased adiposity. Read More

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December 2018