- Joy M Burchell,
- Richard Beatson,
- Rosalind Graham,
- Joyce Taylor-Papadimitriou,
- Virginia Tajadura-Ortega
Biochem Soc Trans 2018 Jun 14. Epub 2018 Jun 14.
Breast Cancer Biology, School of Cancer and Pharmaceutical Sciences, King's College London, Innovation Hub, Guy's Hospital London, London, U.K.
Changes in mucin-type O-linked glycosylation are seen in over 90% of breast cancers where increased sialylation is often observed and a change from branched glycans to linear glycans is often seen. There are many mechanisms involved including increased/altered expression of glycosyltransferases and relocalisation to the endoplasmic reticulum of the enzymes responsible for the addition of the first sugar, -acetyl-d-galactosamine. It is now becoming clear that these changes can contribute to tumour growth and progression by modulating the micro-environment through glycan-sensing lectins expressed on immune cells, by modulating interactions with tumour surface receptors and by binding to selectins. Read More