374,389 results match your criteria Biochemical Pharmacology[Journal]


Cranberry juice decreases disease activity in women with rheumatoid arthritis.

Nutrition 2018 Oct 10;60:112-117. Epub 2018 Oct 10.

Department of Internal Medicine,University of Londrina, Londrina, Paraná, Brazil. Electronic address:

Objectives: Studies have shown that cranberry (Vaccinium macrocarpon) has antiinflammatory and antioxidant effects; however, to our knowledge, the effects of cranberry juice consumption have not been studied in patients with rheumatoid arthritis (RA). The aim of this study was to verify the effect of cranberry juice consumption on several inflammatory biomarkers and on the disease activity of patients with RA.

Methods: A prospective study was conducted with 41 women diagnosed with RA. Read More

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October 2018

The renoprotective effect of the dipeptidyl peptidase-4 inhibitor sitagliptin on adenine-induced kidney disease in rats.

Biomed Pharmacother 2018 Dec 12;110:667-676. Epub 2018 Dec 12.

Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Khod, 123, Oman.

We assessed the effect of treatment with the dipeptidyl peptidase-4 inhibitor, sitagliptin, on adenine-induced chronic kidney disease (CKD). Six equal groups of rats were given either normal food or food mixed with adenine (0.25% w/w for five weeks) to induce CKD. Read More

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December 2018

Plasma and erythrocyte ω-3 and ω-6 fatty acids are associated with multiple inflammatory and oxidative stress biomarkers in breast cancer.

Nutrition 2018 Aug 21;58:194-200. Epub 2018 Aug 21.

Nutrition Department, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Objectives: The aim of this study was to assess the association of plasma and erythrocyte ω-3 and ω-6 fatty acids with multiple oxidative stress biomarkers in breast cancer patients.

Methods: Ninety-five women with recently diagnosed breast cancer and no previous treatment were selected for this study. The socioeconomic, clinical, and demographic profile of the patients was determined using a structured questionnaire and medical records. Read More

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A comprehensive analysis and optimization of continuous twin-screw granulation processes via sequential experimentation strategy.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmaceutics, Rutgers University, Piscataway, NJ 08854, USA; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:

Nowadays twin-screw granulation has been emerging as an attractive continuous wet granulation technique. This study was geared towards better process design and understanding with emphasis on bridging the knowledge gap between input and output variables by employing sequential experimentation strategy. A low-dose formulation for granulation experiments contained anhydrous caffeine as the model drug. Read More

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December 2018

Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone.

Toxicol In Vitro 2018 Dec 12. Epub 2018 Dec 12.

Division of Genetic and Molecular Toxicology, Division of Biochemical Toxicology, National Center for Toxicological Research, U.S Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address:

Many of the toxicants in tobacco smoke undergo biotransformation in the lungs of smokers, both to reactive and to detoxified derivatives. Human air-liquid-interface (ALI) airway tissue models have emerged as an advanced in vitro model for evaluating the toxicity of inhaled substances; however, the metabolic potential of these cultures has not been evaluated extensively. In this study, we compared the metabolic activities of an ALI tissue model to the undifferentiated normal human primary bronchial epithelial (NHBE) cells from which it was derived. Read More

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December 2018
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Osteoarthritis Year in Review 2018: biomarkers (biochemical markers).

Osteoarthritis Cartilage 2018 Dec 12. Epub 2018 Dec 12.

Biomarker and research, Nordic Bioscience, Herlev, Denmark. Electronic address:

Objective: The aim of this narrative review is to summarize important findings from biochemical marker studies relevant to osteoarthritis (OA) in the context of new discoveries and clinical and scientific need.

Design: We conducted a systematic search of electronic medical databases (Embase, Medline, Web of Science, Cochrane central) between 01-03-2017 and 31-03-2018. The search was restricted to human studies, English language and full text available publications while reviews were excluded. Read More

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December 2018

Mechanisms of Pyrethroid Resistance in Aedes (Stegomyia) aegypti from Colombia.

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Centro Internacional de Entrenamiento e Investigaciones Médicas CIDEIM, Carrera 125 N 19-225, Cali, Colombia; Universidad ICESI, Cali,Colombia. Electronic address:

In Colombia Aedes (Stegomyia) aegypti is the main vector of urban arboviruses such as dengue, chikungunya and Zika. This urban mosquito has a well-established capacity to develop insecticide resistance to different types of insecticides (pyrethroids, organochlorides, organophosphates), using multiple resistance mechanisms. An understanding of ongoing resistance mechanisms is critical to determining the activities of vector control programs. Read More

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December 2018

Characterization of two steroid hydroxylases from different Streptomyces spp. and their ligand-bound and -unbound crystal structures.

FEBS J 2018 Dec 15. Epub 2018 Dec 15.

Department of Life Science and Biochemical Engineering, Sunmoon University, Asansi, 31460, Republic of Korea.

Bacterial cytochrome P450 (CYP) enzymes are involved in the hydroxylation of various endogenous substrates while using a heme molecule as a cofactor. CYPs have gained biotechnological interest as useful biocatalysts capable of altering chemical structures by adding a hydroxyl group in a regiospecific manner. Here, we identified, purified, and characterized two CYP154C4 proteins from Streptomyces sp. Read More

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December 2018

Impacts of warming and water deficit on antioxidant responses in Panicum maximum Jacq.

Physiol Plant 2018 Dec 15. Epub 2018 Dec 15.

UNESP-Universidade Estadual Paulista, Faculdade de Ciências Agrarias e Veterinárias -FCAV, Departamento de Biologia Aplicada a Agropecuária (DBAA), 14884-900 Jaboticabal São Paulo, Brazil.

Agricultural activities are affected by many biotic and abiotic stresses associated with global climate change. Predicting the response of plants to abiotic stress under future climate scenarios requires an understanding of plant biochemical performance in simulated stress conditions. In this study the antioxidant response of Panicum maximum Jacq. Read More

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December 2018
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Sensitivity of physiological and biochemical endpoints in early ontogenetic stages of crops under diclofenac and paracetamol treatments.

Environ Sci Pollut Res Int 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Metabolomics and Isotope Analyses, Global Change Research Institute, Czech Academy of Sciences, Bělidla 986/4a, 603 00, Brno, Czech Republic.

Early stages of ontogenesis determining subsequent growth, development, and productivity of crops can be affected by wastewater and sludge contaminated with pharmaceuticals. Diclofenac (DCF) and paracetamol (PCT; both 0.0001 to 10 mg/L) did not affect seed germination and primary root length of onion, lettuce, pea, and tomato. Read More

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December 2018
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Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3.

Pflugers Arch 2018 Dec 14. Epub 2018 Dec 14.

Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effects of D-glucose in the β-cells. The present study extends this analogy to the bioelectrical response of β-cells. Read More

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December 2018

Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues.

Arch Toxicol 2018 Dec 14. Epub 2018 Dec 14.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

Exposure to environmental chemicals has been shown to have an impact on the epigenome. One example is a known human carcinogen 1,3-butadiene which acts primarily by a genotoxic mechanism, but also disrupts the chromatin structure by altering patterns of cytosine DNA methylation and histone modifications. Sex-specific differences in 1,3-butadiene-induced genotoxicity and carcinogenicity are well established; however, it remains unknown whether 1,3-butadiene-associated epigenetic alterations are also sex dependent. Read More

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December 2018

MoVE identifies metabolic valves to switch between phenotypic states.

Nat Commun 2018 Dec 14;9(1):5332. Epub 2018 Dec 14.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.

Metabolism is highly regulated, allowing for robust and complex behavior. This behavior can often be achieved by controlling a small number of important metabolic reactions, or metabolic valves. Here, we present a method to identify the location of such valves: the metabolic valve enumerator (MoVE). Read More

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December 2018

Molecular characterization of LysPBC2, a novel endolysin harboring a spore binding domain.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, and Center for Food and Bioconvergence, Seoul National University, Seoul 08826, South Korea

To control a spore-forming human pathogen , we isolated and characterized a novel endolysin, LysPBC2, from a newly isolated phage PBC2. Compared to the narrow host range of phage PBC2, LysPBC2 showed very broad lytic activity against all , , and species tested. In addition to a catalytic domain and a cell wall binding domain, LysPBC2 has a spore binding domain (SBD) partially overlapped with its catalytic domain, which specifically binds to spores but not to vegetative cells of Both immunogold electron microscopy and binding assay indicate that the SBD binds the external region of the spore cortex layer. Read More

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December 2018

Piercing the lipid raft: the case of cytolysin.

Authors:
Normand Cyr

Biochem J 2018 Dec 14;475(24):3917-3919. Epub 2018 Dec 14.

Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Canada

In a recent issue of , Kathuria et al [ (2018) , 3039-3055] report that membrane binding of the pore-forming toxin cytolysin (VCC) is facilitated by the presence of cholesterol, and the presence of this sterol within the lipid bilayer is key for the formation of a functional pore. Yet, in the presence of accessory non-lipid components, VCC retains its membrane-binding capability likely through membrane lipid raft structures. In light of their results, the authors provide new insights into the roles of cholesterol and of membrane microstructures in the binding, the oligomeric assembly and the cytolytic pore formation of VCC which all take place following infection by . Read More

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December 2018

Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5.

Biol Open 2018 Dec 14;7(12). Epub 2018 Dec 14.

Department of Biochemical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada

Phosphoenolpyruvate carboxykinase (PEPCK1) is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1. Here, we made a series of UBR5 HECT domain truncation variants and, through pull-down assay, showed that the N-terminal lobe of the UBR5 HECT domain is largely responsible for interacting with PEPCK1. We mutated all three lysine residues thought to be acetylated in PEPCK1 but were surprised to observe no loss of binding to UBR5 HECT domain. Read More

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December 2018

Transcription factor TFAP2B up-regulates human corneal endothelial cell-specific genes during corneal development and maintenance.

J Biol Chem 2018 Dec 14. Epub 2018 Dec 14.

Osaka University Graduate School of Medicine, Japan.

The corneal endothelium, which originates from the neural crest via the periocular mesenchyme (PM), is crucial for maintaining corneal transparency. The development of corneal endothelial cells (CECs) from the neural crest is accompanied by the expression of several transcription factors, but the contribution of some of these transcriptional regulators to CEC development is incompletely understood. Here, we focused on activating enhancer-binding protein 2 (TFAP2, AP-2), a neural crest-expressed transcription factor. Read More

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December 2018

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.

EMBO Mol Med 2018 Dec 14. Epub 2018 Dec 14.

MRC-Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

Loss-of-function mutations in , a gene exclusively found in higher eukaryotes, cause a characteristic type of cavitating leukoencephalopathy associated with mitochondrial cytochrome oxidase (COX) deficiency. Although the genetic association of APOPT1 pathogenic variants with isolated COX defects is now clear, the biochemical link between APOPT1 function and COX has remained elusive. We investigated the molecular role of APOPT1 using different approaches. Read More

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December 2018

The surgical management of sporadic primary hyperparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 6. Epub 2018 Dec 6.

University Hospital of Wales, Heath Park Way, Cardiff, CF14 4XW, UK. Electronic address:

Sporadic primary hyperparathyroidism (pHPT) is the commonest cause of hypercalcaemia in the ambulatory population. It has a female preponderance and its incidence is increasing. In 85% of cases it is caused by a single parathyroid adenoma, with four gland hyperplasia in up to 20%. Read More

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December 2018

Parathyroid carcinoma.

Best Pract Res Clin Endocrinol Metab 2018 Dec 1. Epub 2018 Dec 1.

Departments of Laboratory Medicine and Pathobiology, Medicine and Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Parathyroid carcinoma (PC) is a rare disease with an indolent behavior due to the low malignant potential. The etiology is unknown. Somatic mutations of CDC73 gene, the same gene involved in the hyperparathyroidism-jaw tumor syndrome, can be identified in up to 70% of patients with PC and in one-third of cases the mutations are germline. Read More

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December 2018

Design and assessment of an active anti-epidermal growth factor receptor (EGFR) single chain variable fragment (ScFv) with improved solubility.

Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei-shi, Tokyo, 184-8588, Japan. Electronic address:

ScFv is emerging as a therapeutic alternative to the full-length monoclonal antibodies due to its small size and low production cost, but its low solubility remains a limiting factor toward wider use. Here, we increased the solubility of an Anti-epidermal growth factor receptor ScFv (Anti-EGFR ScFv) by attaching, a short 12-residue solubility enhancing peptide (SEP) tag at its C terminus. We first estimated the solubility increase by running 500-ns Brownian dynamics (BD) simulations. Read More

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December 2018

Identification of Brucella abortus biovar 4 of bovine origin in Colombia.

Rev Argent Microbiol 2018 Dec 11. Epub 2018 Dec 11.

Corporación Colombiana de Investigación Agropecuaria AGROSAVIA, Centro de investigación Tibaitatá, Km 14 vía Mosquera-Bogotá, Mosquera, Colombia. Electronic address:

The objective of this study was to identify twelve Brucella abortus isolates of bovine origin from the department of Nariño in Colombia up to the biovar level. These isolates are included in the collection of the Germplasm Bank of Microorganisms of Animal Health Interest - Bacteria and Virus (BGSA-BV). The identification was carried out through conventional methods such as macro and microscopic morphological descriptions, enzymatic activity, biochemical profile, substrate use and sensitivity to dyes. Read More

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December 2018

Succinate dehydrogenase mutations: paraganglioma imaging and at-risk population screening.

Clin Radiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiology, St George's University Hospitals NHS Foundation Trust, UK.

Paragangliomas are rare vascular tumours of the autonomic nervous system. They can be classified as sympathetic or parasympathetic. Sympathetic paragangliomas, which include phaeochromocytomas, tend to be functional and symptomatic. Read More

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December 2018

Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.

Leptin, a hormone secreted by peripheral adipose tissues, regulates the appetite in animals. Recently, evidence has shown that leptin also plays roles in behavioral response in addition to controlling appetite. In this study, we examined the potential function of leptin on non-appetite behaviors in zebrafish model. Read More

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December 2018
2.862 Impact Factor

MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients.

Cells 2018 Dec 13;7(12). Epub 2018 Dec 13.

Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for the deterioration of the clinical status of a patient, and increased mortality rates. From a molecular viewpoint, microRNAs are one of the most complex macromolecular systems due to the numerous modular reactions and interactions that they are involved in. Read More

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December 2018
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Structural Features and Binding Modes of Thioether-Cyclized Peptide Ligands.

Biomedicines 2018 Dec 13;6(4). Epub 2018 Dec 13.

Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, 113-0033 Tokyo, Bunkyo-ku, Japan.

Macrocyclic peptides are an emerging class of bioactive compounds for therapeutic use. In part, this is because they are capable of high potency and excellent target affinity and selectivity. Over the last decade, several biochemical techniques have been developed for the identification of bioactive macrocyclic peptides, allowing for the rapid isolation of high affinity ligands to a target of interest. Read More

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December 2018

Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat.

Biomed Pharmacother 2019 Jan 5;109:892-901. Epub 2018 Nov 5.

Anatomy and Embryology Department, Faculty of Medicine, Ain Shams University, P.O. box 11381, Abbassia, Cairo, Egypt.

The present study was conducted to investigate the potential protective effects of coenzyme Q 10 (CoQ10) administration on methotrexate induced lung and liver fibrosis in rat model, and to explore our hypothesis regarding its possible mechanism of action through reactivation of autophagy pathway. Methotrexate induced fibrosis was achieved by intraperitoneal injections twice a week for 4 weeks. A combined treatment of CoQ10 and methotrexate were used. Read More

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January 2019

Protective effect of Centella asiatica against -galactose and aluminium chloride induced rats: Behavioral and ultrastructural approaches.

Biomed Pharmacother 2019 Jan 5;109:853-864. Epub 2018 Nov 5.

Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia. Electronic address:

Background: Alzheimer's disease (AD) is a neurodegenerative disorder and the commonest cause of dementia among the aged people. -galactose (D-gal) is a senescence agent, while aluminium is a known neurotoxin linked to pathogenesis of AD. The combined administration of rats with d-gal and aluminium chloride (AlCl) is considered to be an easy and a cheap method to obtain an animal model of AD. Read More

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January 2019

Effect of gemfibrozil on cardiotoxicity induced by doxorubicin in male experimental rats.

Biomed Pharmacother 2019 Jan 6;109:530-535. Epub 2018 Nov 6.

Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Electronic address:

Cardiotoxicity is an adverse effect of the anticancer drug doxorubicin (DOX). Gemfibrozil (GEM) is a lipid-lowering drug with a number of biological properties such as anti-inflammatory and antioxidant activities. Therefore, we decided to investigate the effect of GEM on DOX-induced cardiotoxicity in rats. Read More

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January 2019

Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model.

Biomed Pharmacother 2019 Jan 28;109:2285-2292. Epub 2018 Nov 28.

Institute of Microbiology, University of Agriculture, Faisalabad, 38040, Pakistan.

Cinnamomum zeylanicum, a widely used spice and flavor, is used in the treatment and prevention of many diseases. In the current study, Balb/c mice were pretreated with cinnamon bark aqueous extract (200 mg/kg/day i.g. Read More

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January 2019

Fibronectin promotes nasopharyngeal cancer cell motility and proliferation.

Biomed Pharmacother 2019 Jan 26;109:1772-1784. Epub 2018 Nov 26.

Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Nasopharyngeal cancer (NPC) is an Epstein-Barr virus (EBV)-associated carcinoma. Fibronectin is regarded as a prognosticator in NPC and its involvement in cell motility has been reported in EBV infection and viral latent membrane protein 1 (LMP1) overexpression NPC cell lines. However, its malignant potential in NPC cell lines without harbouring the EBV genome has not been investigated. Read More

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January 2019

Protective effect of Convolvulus pluricaulis against neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat.

Biomed Pharmacother 2019 Jan 20;109:1698-1708. Epub 2018 Nov 20.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, 400 056, India.

Depression is a heterogeneous disorder and has been regarded as an inflammatory disease. The aerial parts of the Convolvulus pluricaulis are used in Indian traditional medicines for the management of nervous disorders. However, the influence of methanolic extract of aerial parts of Convolvulus pluricaulis (CPE) on a chronic animal model of depression has not been investigated yet, and associated biochemical changes are still unclear. Read More

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January 2019

Establishment of in vitro and in vivo anti-colon cancer efficacy of essential oils containing oleo-gum resin extract of Mesua ferrea.

Biomed Pharmacother 2019 Jan 15;109:1620-1629. Epub 2018 Nov 15.

EMAN Testing and Research Laboratory, Department of Pharmacology, School of Pharmaceutical Sciences, Universti Sains Malaysia, Penang, 11800, Malaysia; ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, Australian National University, Australia. Electronic address:

Proven the great potential of essential oils as anticancer agents, the current study intended to explore molecular mechanisms responsible for in vitro and in vivo anti-colon cancer efficacy of essential oil containing oleo-gum resin extract (RH) of Mesua ferrea. MTT cell viability studies showed that RH had broad spectrum cytotoxic activities. However, it induced more profound growth inhibitory effects towards two human colon cancer cell lines i. Read More

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January 2019
2 Reads

Involvement of the uridine cytidine kinase 2 enzyme in cancer cell death: A molecular crosstalk between the enzyme and cellular apoptosis induction.

Biomed Pharmacother 2019 Jan 14;109:1506-1510. Epub 2018 Nov 14.

UPM-MAKNA Cancer Research Lab, Institute of Bioscience, Universiti Putra Malaysia, Malaysia. Electronic address:

Apoptosis is a series of molecular signalling regulating normal cellular growth and development. Cells resistance to apoptosis, however, leads to uncontrolled proliferation. Research involving cancer cell death is one of the most important targeted areas in the discovery of novel anticancer therapy. Read More

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January 2019

Neuroprotective effects of 1`δ-1`-acetoxyeugenol acetate on Aβ induced cognitive dysfunction in mice.

Biomed Pharmacother 2019 Jan 13;109:1454-1461. Epub 2018 Nov 13.

Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, 506009, India. Electronic address:

The progressive accumulation of amyloid beta (Aβ) peptide is neurotoxic and leads to Alzheimer's type dementia. Accumulation of Aβ has been associated with dysfunction of hypothalamic-pituitary-adrenal (HPA) axis and elevated pro-inflammatory cytokines. In this study, we investigated the effect of 1`δ-1`-acetoxyeugenol acetate (DAEA), isolated from Alpinia galanga (L. Read More

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January 2019

Effects of nimodipine, vinpocetine and their combination on isoproterenol-induced myocardial infarction in rats.

Biomed Pharmacother 2019 Jan 12;109:1372-1380. Epub 2018 Nov 12.

Department of Pharmacology, School of Pharmaceutical Education & Research (SPER), Jamia Hamdard, New Delhi, 110062, India. Electronic address:

Background: Myocardial infarction (MI) remains a major cause of morbidity and mortality worldwide. Nimodipine is a calcium (Ca channel blocker as well as a PDE1 inhibitor and primarily used in subarachnoid haemorrhage (SAH) due to its blood-brain barrier crossing property. Nimodipine and vinpocetine inhibit the degradation of phosphodiester bond which increases cGMP and cAMP levels causing vasodilation. Read More

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January 2019
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Vitamin D and liver fibrosis: Molecular mechanisms and clinical studies.

Biomed Pharmacother 2019 Jan 10;109:1351-1360. Epub 2018 Nov 10.

Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. Electronic address:

Vitamin D plays a primary role in regulation of bone metabolism and calcium homeostasis. Interestingly, emerging evidence suggests protective effects of vitamin D against liver fibrogenesis. However, the precise mechanisms of this action remain mysterious. Read More

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January 2019

In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature.

Biomed Pharmacother 2019 Jan 6;109:1085-1099. Epub 2018 Nov 6.

State key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, 211198, China. Electronic address:

Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly centers on recent ten years findings with respect to intervening diabetes and its complications with the well-known flavonoid quercetin. After a short introduction of quercetin, major in vitro and in vivo findings are summarized showing that quercetin is a promising molecule for the treatment of these diseases. Read More

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January 2019
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The effects of early treatment with anti-venom on length of hospital stay: Analysis of 46 cases of mamushi bites.

Chudoku Kenkyu 2017 Mar;30(1):25-30

To investigate the effectiveness of mamushi anti-venom, we examined the relationships between the length of hospital stay (LOS) and the anti-venom administration, LOS and intervals of the bite and administration of the anti-venom, and severity of the bite and initial laboratory data. The sample of this study was a total of 46 cases who were admitted for mamushi bite from 2003 to 2013 to our hospital. Data was collected from medical records retrospectively. Read More

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Increased incidence rate of hypothyroidism after iodine fortification in Denmark. A 20 year prospective population-based study.

J Clin Endocrinol Metab 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology, Aalborg University Hospital, Denmark.

Objective: To monitor the impact of a cautious iodine fortification (IF) on the incidence of overt hypothyroidism in two sub-populations with different levels of preexisting iodine deficiency (ID).

Design: A 20 years (1997-2016) prospective population-based study identified all new cases of diagnosed overt biochemical hypothyroidism in two open cohorts: a Western cohort with moderate ID (n=309,434, January 1st, 1997) and an Eastern cohort with mild ID (n=224,535, January 1st, 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas and possible new cases were verified individually. Read More

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December 2018

Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress.

Environ Toxicol Pharmacol 2018 Dec 5;65:60-65. Epub 2018 Dec 5.

College of Pharmacy, Guangxi Medical University, Guangxi, Nanning, 530021, PR China. Electronic address:

Our previous studies show that vitamin C (VC) plays promising hepatoprotection in mice. Intrahepatic exposure of perfluorooctane sulfonate (PFOS) can induce dose-dependent cytotoxicity. However, pharmacology-based assessment of VC on PFOS remains uninvestigated. Read More

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December 2018
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Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant.

Biomaterials 2018 Dec 10;193:1-11. Epub 2018 Dec 10.

Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China. Electronic address:

Mild heat stimulation can promote the restoration of bone defects but unfortunately, the delivery of exo-hyperthermy into human body is not efficient enough. In this study, mild heat-induced osteogenesis with high efficacy is demonstrated on an osteoimplant composed of black phosphorus nanosheets and poly(lactic-co-glycolic acid) (BPs@PLGA) with the participation of near-infrared (NIR) light irradiation. BPs@PLGA with only 0. Read More

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December 2018
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Pediatric reference intervals for clinical chemistry assays on Siemens ADVIA XPT/1800 and dimension EXL in the CALIPER cohort of healthy children and adolescents.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, ON M5S 1A8, Canada. Electronic address:

Introduction: Accurate reference intervals (RIs) are essential for clinical interpretation of laboratory test results; however, major gaps exist in pediatric RIs. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) has established age- and sex-specific pediatric RIs on various analytical platforms. The current study expands the CALIPER database by establishing age- and sex-specific RIs for biochemical assays on Siemens ADVIA XPT/1800 and Dimension EXL Systems. Read More

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December 2018

Can nutrient fertilization mitigate the effects of ozone exposure on an ozone-sensitive poplar clone?

Sci Total Environ 2018 Nov 30;657:340-350. Epub 2018 Nov 30.

Institute for Sustainable Plant Protection, National Research Council, Via Madonna del Piano 10, Sesto Fiorentino, Florence 50019, Italy.

We tested the independent and interactive effects of nitrogen (N; 0 and 80 kg ha), phosphorus (P; 0, 40 and 80 kg ha), and ozone (O) application/exposure [ambient concentration (AA), 1.5 × AA and 2.0 × AA] for five consecutive months on biochemical traits of the O-sensitive Oxford poplar clone. Read More

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November 2018

The protective effect of zeranol in cerebral ischemia reperfusion via p-CREB overexpression.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt. Electronic address:

Aims: Cerebral ischemia reperfusion (I/R) is a neurovascular disease leading to cerebral damage. It was found that postmenopausal women are liable to more dangerous effects than men at same age in stroke. The objective of this study is to investigate the neuroprotective effect of zeranol against cerebral ischemia reperfusion in ovariectomized rats. Read More

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December 2018

Dissecting the Thermodynamic Contributions of the Charged Residues in the Membrane Anchoring of Bcl-xl C-Terminal Domain.

Chem Phys Lipids 2018 Dec 11. Epub 2018 Dec 11.

Bioinformatics Centre, Bose Institute, P-1/12 C.I.T. Scheme VII M, Kolkata, 700054, India. Electronic address:

The C-terminal helix of the Bcl-xl is known to initiate the membrane insertion of the protein by anchoring into the mitochondrial outer membrane. The C-terminal charged residues of that helix, R232, and K233, are reported to have an important structural role in the process of insertion. The present work provides a quantitative understanding of the thermodynamic contribution of these residues on the membrane insertion profile from Adaptive Biasing Force based MD simulations of 2. Read More

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December 2018

Biochemical characterization of a native group III trypsin ZT from Atlantic cod (Gadus morhua).

Int J Biol Macromol 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland. University of Iceland, Sæmundargata 2, 101 Reykjavik, Iceland. Electronic address:

Atlantic cod trypsin ZT is biochemically characterized for the first time in this report in comparison to a group I trypsin (cod trypsin I). To our knowledge, trypsin ZT is the first thoroughly characterized group III trypsin. A more detailed understanding of trypsin ZT biochemistry may give insight into its physiological role as well as its potential use within the biotechnology sector. Read More

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December 2018

Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR-/- mice.

Nanomedicine 2018 Dec 11. Epub 2018 Dec 11.

Institute of Physiology II, University of Münster, Münster, Germany; Institute of Physiology, University of Lübeck, Lübeck, Germany. Electronic address:

Endothelial dysfunction is recognized as a critical condition in the development of cardiovascular disorders. This multifactorial process involves changes in the biochemical and mechanical properties of endothelial cells leading to disturbed release of vasoprotective mediators. Hypercholesterolemia and increased stiffness of the endothelial cortex are independently shown to result in reduced release of nitric oxide and thus endothelial dysfunction. Read More

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December 2018

Multisensory Logic of Infant-Directed Aggression by Males.

Cell 2018 Dec;175(7):1827-1841.e17

Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

Newborn mice emit signals that promote parenting from mothers and fathers but trigger aggressive responses from virgin males. Although pup-directed attacks by males require vomeronasal function, the specific infant cues that elicit this behavior are unknown. We developed a behavioral paradigm based on reconstituted pup cues and showed that discrete infant morphological features combined with salivary chemosignals elicit robust male aggression. Read More

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December 2018
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