Systems analysis of metabolism in platelet concentrates during storage in platelet additive solution.
- Freyr Jóhannsson,
- Steinn Guðmundsson,
- Giuseppe Paglia,
- Sveinn Guðmundsson,
- Bernhard Palsson,
- Ólafur E Sigurjónsson,
- Óttar Rolfsson
Biochem J 2018 Jun 18. Epub 2018 Jun 18.
Center for Systems Biology, University of Iceland, Sturlugata 8, Reykjavík, 101, Iceland
Platelets deteriorate over time when stored within blood banks through a biological process known as platelet storage lesion (PSL). Here we describe the refinement of biochemical network of platelet metabolism iAT-PLT-636 and its application to describe and investigate changes in metabolism during platelet storage. Changes to extracellular acetate and citrate were measured in buffy coat and apheresis platelet units over 10 days of storage in the platelet additive solution T-Sol. Read More