Biochem Eng J 2018 Mar 13;131:39-46. Epub 2017 Dec 13.
Department of Chemical and Biomedical Engineering, Florida State University, 2525 Pottsdamer St., Tallahassee, FL 32310, USA.
Three-dimensional aggregation of human mesenchymal stem cells (hMSCs) has been used to enhance their therapeutic properties but current fabrication protocols depend on laboratory methods and are not scalable. In this study, we developed thermal responsive poly(N-isopropylacrylamide) grafted microcarriers (PNIPAM-MCs), which supported expansion and thermal detachment of hMSCs at reduced temperature (23.0 °C). Read More