86,091 results match your criteria Biochem. Biophys. Res. Commun.[Journal]


Inhibition of GIP signaling extends lifespan without caloric restriction.

Biochem Biophys Res Commun 2019 Apr 17. Epub 2019 Apr 17.

Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine, Japan. Electronic address:

Aims/introduction: Caloric restriction (CR) promotes longevity and exerts anti-aging effects by increasing Sirtuin production and activation. Gastric inhibitory polypeptide (GIP), a gastrointestinal peptide hormone, exerts various effects on pancreatic β-cells and extra-pancreatic tissues. GIP promotes glucose-dependent augmentation of insulin secretion and uptake of nutrients into the adipose tissue. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.036DOI Listing
April 2019
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Corrigendum to 'Long non-coding RNA Linc00320 inhibits glioma cell proliferation through restraining Wnt/β-catenin signaling', Biochem Biophys Res Commun. 2019 Jan 8; 508(2):458-464.

Biochem Biophys Res Commun 2019 Apr 17. Epub 2019 Apr 17.

Department of Functional Neurosurgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Second Road, Shanghai, 200240, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.04.071DOI Listing

Determinants of lentiviral Vpx-CRL4 E3 ligase-mediated SAMHD1 degradation in the substrate adaptor protein DCAF1.

Biochem Biophys Res Commun 2019 Apr 17. Epub 2019 Apr 17.

Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, 130021, China; Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, China. Electronic address:

The lentiviral accessory protein Vpx enhances viral replication in macrophages, dendritic cells and resting CD4 T cells by utilizing the host CRL4-DCAF1 E3 ligase to trigger the degradation of the intrinsic antiviral factor SAMHD1. Distinct from the species-specific recognition of either the N or C-terminus of SAMHD1 by Vpx proteins of different HIV-2 and SIV lineages, Vpx recruits SAMHD1 onto the same CRL4-DCAF1 complex. However, the determinants in DCAF1 that are required for Vpx-mediated SAMHD1 degradation have not been well characterized. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.085DOI Listing

Long non-coding RNA LOXL1-AS1 acts as a ceRNA for miR-324-3p to contribute to cholangiocarcinoma progression via modulation of ATP-binding cassette transporter A1.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, 161000, China. Electronic address:

Accumulating evidence has appreciated long non-coding RNAs (lncRNAs) as novel prognostic markers and therapeutic targets in malignant carcinomas. Here, we aim to investigate the value of a novel cancer-related lncRNA, LOXL1-AS1, in cholangiocarcinoma (CCA). LOXL1-AS1 was found overexpressed in CCA tissues screened by high-throughput sequencing technology. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.089DOI Listing

Prenylated Rab acceptor RABAC1 inhibits anti-apoptotic protein BCL2A1 and induces apoptosis.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Department of Biomolecular Science, University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

The B cell lymphoma 2 (BCL2) family of proteins constitutes a critical intracellular checkpoint in the intrinsic apoptosis pathway. Among BCL2 members, the anti-apoptotic protein BCL2A1 mediates the resistance to BCL2 inhibitors and may be considered as a target for anti-cancer therapy. Here, we report that prenylated Rab acceptor 1 (RABAC1 or PRA1) inhibits the anti-apoptotic activity of BCL2A1 and induces apoptosis in AGS gastric cancer cells. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.080DOI Listing

NIPA2 regulates osteoblast function via its effect on apoptosis pathways in type 2 diabetes osteoporosis.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedics, The First Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address:

Type 2 diabetes osteoporosis has recently become a hot topic in the study of diabetic complications, but the specific mechanism of its development remains unclear. Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 (NIPA2), a highly-selective magnesium ion transporter, has been found to be associated with type 2 diabetes. In this study we aimed to investigate the specific role and mechanism of NIPA2 in the pathogenesis of type 2 diabetes osteoporosis. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.030DOI Listing

Tetrandrine induces apoptosis in human neuroblastoma through regulating the Hippo/YAP signaling pathway.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China. Electronic address:

Tetrandrine (TET), a bis-benzylisoquinoline alkaloid, shows cytotoxicity against several different types of tumors. However, the mechanism by which TET exerts its anti-cancer capabilities remains unclear. In this study, we confirmed that TET inhibits proliferation and induces apoptosis in neuroblastoma (NB) in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.075DOI Listing

Construction of the common cortical space by spontaneous activity and its application in the mouse cortex.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.

Wide-field optical imaging of the animal brain is a useful technique for measuring brain dynamics, including spatial structure. However, quantitative inter-animal comparison is difficult due to lack of the common cortical space that can normalize individually imaged brains as done in human functional MRI studies. Here, by using wide-field functional Ca imaging on anesthetized transgenic mice expressing G-CaMP7 in astrocytes and excitatory neutrons, we attempted to establish the common cortical space in mice, which can be useful as a standard of functional brain map. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.048DOI Listing

Single-molecule nanomechanical spectroscopy shows calcium ions contribute to chain association and structural flexibility of blood clotting factor VIII.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China; ZhangJiang Lab, Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210, China. Electronic address:

Blood coagulation factor VIII (FVIII) can bind calcium ions and ion-protein interactions appear central importance for both their structure and function in coagulation cascade. However, the mechanism and details of how calcium dependent structure change of proteins to fulfill their function remain to be fully defined. In this work, PeakForce Quantitative Nanomechanics (PF-QNM) mode atomic force microscopy (AFM) was used to map the topography and mechanical properties of FVIII with single protein resolution under different calcium concentrations. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.068DOI Listing

Microglia promote the proliferation of neural precursor cells by secreting osteopontin.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo, 187-8502, Japan. Electronic address:

Microglia are central nervous system-resident immune cells that play a crucial role in brain development by interacting with neural precursor cells (NPCs). It has been reported that microglia regulate the number of NPC by phagocytosis, inducing apoptosis, and promoting proliferation. Microglia surrounding the subventricular zone express osteopontin (OPN) during brain development. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.076DOI Listing

MicroRNA-146b-5p protects oligodendrocyte precursor cells from oxygen/glucose deprivation-induced injury through regulating Keap1/Nrf2 signaling via targeting bromodomain-containing protein 4.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Institute of Neurobiology, The Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.

The injury of oligodendrocyte precursor cells (OPCs) contributes to the pathology of hypoxic-ischemic encephalopathy in newborns. MicroRNAs (miRNAs) have emerge as critical regulators of hypoxic-ischemic encephalopathy; however, the role of miRNAs in regulating OPC injury remains largely unknown. MiRNA-146b-5p (miR-146b-5p) has been reported to exert a cytoprotective function under various pathological conditions. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.045DOI Listing
April 2019
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Process of immunogenic cell death caused by disulfiram as the anti-colorectal cancer candidate.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Immunology, School of Life Sciences and Biopharmaceuticals Engineering, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Guangdong Engineering & Technology Research Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Key Laboratory of Digital Quality Evaluation of Chinese Medical of State Administration of TCM, Guangzhou, 510006, PR China. Electronic address:

Background: Disulfiram (DSF), a drug widely used to control alcoholism, which has anticancer activity by inducing apoptosis in a copper (Cu)-dependent manner. Numerous evidences from mouse experiments indicated that some anti-cancer agents of chemotherapeutic drugs favor the induction of immunogenic cancer cell death (ICD) leading to tumor-specific immune responses. However, whether DSF could induce the colorectal tumor cells death and the mechanism involved in ICD regulatory remains elusive. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.192DOI Listing
April 2019
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Effects of epigallocatechin-3-gallate on the HMGB1/RAGE pathway in PM-exposed asthmatic rats.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, Children's Hospital Affiliated of Zhengzhou University, No.33 Long hu Wai huan East Road, Zhengzhou, 450018, Henan, China. Electronic address:

Current studies have shown that long-term exposure to fine particulate matter (PM) can aggravate lung injury in asthmatic children. The HMGB1/RAGE pathway may play an important role, but few studies on the HMGB1/RAGE signaling pathway in PM-induced asthma have been performed. Epigallocatechin-3-gallate (EGCG), which has antioxidant, anti-inflammatory and immunomodulatory effects, has not been examined in studies at home and abroad. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.165DOI Listing

Exosomes derived from plasma of septic patients inhibit apoptosis of T lymphocytes by down-regulating bad via hsa-miR-7-5p.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Respiratory Medicine, Chinese PLA General Hospital, 28th Fuxing Road, Beijing, 100853, PR China. Electronic address:

Immunosuppression is currently a vital pathophysiological characteristic and core problem of sepsis. Apoptosis of T lymphocyte contribute to immunosuppression by decreasing immune effector cells. A report has recently revealed the potential regulatory role of exosomal miRNAs derived from plasma of septic patients on immune system, but the underlying mechanism is unclear. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.051DOI Listing

Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Interventional Radiology, Zhongshan Hospital, Fudan University, China. Electronic address:

Hepatocellular carcinoma (HCC) presents a great burden for patients worldwide, and metastasis of HCC remains problematic. Arsenic trioxide is a traditional drug that has shown excellent efficacy when applied as cancer therapy. Our study explored the antimetastatic mechanism of arsenic trioxide in HCC. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.081DOI Listing
April 2019
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Dysregulation of humoral immunity in Foxp3 conditional-knockout mice.

Biochem Biophys Res Commun 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Pharmaceutical Immunology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan. Electronic address:

Foxp3 regulatory T cells (Tregs) are crucial for maintaining tolerance to self-antigens and preventing autoimmune diseases. Loss of Foxp3 expression leads to autoimmunity and disrupts humoral immune responses, including hyperproduction of immunoglobulin E (IgE). Elucidation of how Tregs control antibody production can lead to the development of new therapies for autoimmune and allergic diseases. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.090DOI Listing
April 2019
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Diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide: Isolation and properties.

Biochem Biophys Res Commun 2019 Apr 15. Epub 2019 Apr 15.

Institute of Chemical Biology and Fundamental Medicine, SB RAS, 8 Lavrentiev Avenue, Novosibirsk, 630090, Russia; Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia.

Recently, a new type of nucleic acid analogues with modified phosphate group, namely, phosphoryl guanidine oligonucleotides, has been described. In the present work, we assess the difference between diastereomers of a mono-substituted phosphoryl guanidine oligonucleotide and analyze their resistance to nuclease digestion. Individual diastereomers ('fast' and 'slow') of a trideoxynucleotide d (TpCp*A) were isolated by reverse-phase HPLC. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.024DOI Listing

IGF2BP1 promotes LPS-induced NFκB activation and pro-inflammatory cytokines production in human macrophages and monocytes.

Biochem Biophys Res Commun 2019 Apr 15. Epub 2019 Apr 15.

Department of Stomatology, Nanfang Hospital and College of Stomatology, Southern Medical University, Guangzhou, China. Electronic address:

Background: Lipopolysaccharide (LPS)-induced macrophage/monocyte activation and pro-inflammatory cytokines production are important mediators for periodontitis progression. The current study tested the potential role of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in the process.

Methods: THP-1 human macrophages and primary human peripheral blood mononuclear cells (PBMCs) were treated with LPS. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.206DOI Listing

Sestrin 2 protects against metabolic stress in a p53-independent manner.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry & Molecular Biology, China Medical University, Shenyang, 110026, China; Key Laboratory of Cell Biology, Ministry of Public Health, And Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, 110026, China. Electronic address:

Glucose limitation activates p53, which functions as an adaptive response to maintain cell survival. However, p53 is frequently deleted or mutated in a variety of tumors, while most cancer cells can acclimatize themselves to metabolically unfavorable surrounding, indicating that alternative mechanisms other than p53 transactivation underly adaptive response of cancer cells with p53 deletion or mutation to metabolically hostile environment. Sestrin 2 (SESN2) is a p53 downstream target, which plays a protective role against various stressful stimuli, such as genotoxic, energetic, and oxidative stress. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.072DOI Listing
April 2019
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Interleukin-6 is required for Neuregulin-1 induced HER2 signaling in lung epithelium.

Biochem Biophys Res Commun 2019 Apr 15. Epub 2019 Apr 15.

Department of Medicine, National Jewish Health, Denver, CO, United States. Electronic address:

A clear understanding of the mechanisms that regulate the alveolar epithelium's barrier is critical to develop new therapeutic strategies to mitigate lung injury. The HER2/HER3 receptor tyrosine kinase complex plays a central role in maintaining the alveolar-capillary barrier. This receptor complex is activated by its ligand, neuregulin-1 (NRG-1). Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.070DOI Listing
April 2019
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microRNA-4500 inhibits human glioma cell progression by targeting IGF2BP1.

Biochem Biophys Res Commun 2019 Apr 15. Epub 2019 Apr 15.

Neurosurgery Department, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China. Electronic address:

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) overexpression promotes glioma cell progression. The aim of the current study is to silence IGF2BP1 in glioma cells by the microRNA (miRNA) strategy. The bio-informatic analyses identified that microRNA-4500 (miR-4500) putatively targets 3'-UTR (3'-untranslated region) of IGF2BP1. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.058DOI Listing
April 2019
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Ribavirin sensitizes nasopharyngeal carcinoma to 5-fluorouracil through suppressing 5-fluorouracil-induced ERK-dependent-eIF4E activation.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Electronic address:

Although overexpression of eukaryotic translation initiation factor 4E (eIF4E) is associated with enhanced growth and poor prognosis in nasopharyngeal carcinoma (NPC), the function of eIF4E in NPC response to chemotherapy has not been revealed. In this work, we demonstrate that eIF4E inhibition using both ribavirin and siRNA targets NPC cells and enhances the efficacy of 5-fluorouracil (5-FU). Mechanism studies indicate that 5-FU treatment increases phosphorylation of eIF4E in NPC cells, and this is dependent on ERK activation. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.053DOI Listing
April 2019
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A novel circular RNA circ-ZNF652 promotes hepatocellular carcinoma metastasis through inducing snail-mediated epithelial-mesenchymal transition by sponging miR-203/miR-502-5p.

Biochem Biophys Res Commun 2019 Apr 15. Epub 2019 Apr 15.

Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, PR China. Electronic address:

Circular RNA (circRNA), a special class of non-coding RNA, is increasingly being realized as a critical regulator in human diseases, including carcinomas. However, its role in hepatocellular carcinoma (HCC) metastasis remains largely unknown. Herein, we enrolled three Gene Expression Omnibus (GEO) databases and screened and identified a novel circRNA, circ-ZNF652 (hsa_circ_0003258), which was significantly upregulated in HCC tissues and cell lines. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.214DOI Listing

Construction of the safe neutralizing assay system using pseudotyped Nipah virus and G protein-specific monoclonal antibody.

Biochem Biophys Res Commun 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, Republic of Korea; Department of Bio-industrial Technologies, Konkuk University, Seoul, 05029, Republic of Korea. Electronic address:

Nipah virus (NiV) is a recently emerged paramyxovirus that causes acute respiratory illness and fatal encephalitis in a broad spectrum of vertebrates, including humans. Due to its high pathogenicity and mortality rates, NiV requires handling in biosafety level-4 (BSL-4) containment facilities and no effective vaccines or therapeutic agents are currently available. Since current diagnostic tests for detecting serum neutralizing antibodies against NiV mainly employ live viruses, establishment of more safe and robust alternative diagnostic methods is an essential medical requirement. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.212DOI Listing

Distinct roles of Deinococcus radiodurans RecFOR and RecA in DNA transformation.

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, 310029, China. Electronic address:

RecFOR and RecA are key recombination factors in Deinococcus radiodurans, a bacterium that possesses robust DNA repair capability and is also naturally transformable. While RecFOR functioning as a RecA loader during DNA repair has been established, their relative roles in transformation need further exploration. Here, we constructed recFOR and recA deletion mutants of D. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.042DOI Listing
April 2019
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Modulation of the cell cycle regulating transcription factor E2F1 pathway by the proteasome following amino acid starvation.

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

Technion Integrated Cancer Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, 3109601, Israel. Electronic address:

The proteasome is one of the main catalytic machineries of eukaryotic cells responsible for protein degradation, and is known to be regulated during several cellular stress conditions. Recent studies suggest that the activity of the proteasome is modulated following mTOR inhibition. However, it is not clear how this process affects the proteome. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.066DOI Listing
April 2019
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CACNB2 is associated with aberrant RAS-MAPK signaling in hypertensive Dahl Salt-Sensitive rats.

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

Department of Physiology and Pharmacology, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA. Electronic address:

Several independent genome-wide association studies (GWAS) have indicated that calcium (Ca) voltage-gated channel auxiliary subunit beta 2 (CACNB2) an L-type Ca channel (LTCC) associated protein has strong association with hypertension. However, the molecular mechanism of CACNB2 and its role in the pathophysiology of hypertension is not clear. To address this knowledge gap, we utilized in vitro and in vivo approaches using HEK293 cells and genetically hypertensive, Dahl Salt-Sensitive (SS) rats. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.215DOI Listing
April 2019
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Hd3a and OsFD1 negatively regulate rice resistance to Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicola.

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, 430070, China. Electronic address:

In rice, Hd3a, GF14 and OsFD1 proteins, forming florigen activation complex, are key components in flowering time regulation. GF14 genes in rice response to biotic and abiotic stress has also been well addressed. The role of GF14e in rice defense has been well studied. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.169DOI Listing
April 2019
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Subpollens delivery of Platanus acerifolia pollen allergen Pla a3 and nucleic acid into lungs and cells.

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China. Electronic address:

Pollen allergy is a very serious seasonal respiratory disease. However, there has been a lack of understanding how pollen allergens enter the body and act on cells. This study focused on the release, transport and characteristic of Pla a3 allergen of the Platanus acerifolia pollen. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.210DOI Listing

Structural and mechanistic insights into modified G-quadruplex thrombin-binding DNA aptamers.

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, China.

Thrombin-binding aptamer (TBA) can fold into a G-quadruplex structure necessary for interacting with thrombin. When one thymidine residue of the TGT loop at position 7 is replaced with unlocked uracil (UNA), d-isothymidine (D-isoT) or l-isothymidine (L-isoT), these modified sequences display different activities. To date, the mechanisms of how D/L-isoT and UNA influence the biological properties of TBA have not been illustrated in the literature. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.025DOI Listing

Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells.

Biochem Biophys Res Commun 2019 Apr 12. Epub 2019 Apr 12.

Department of Molecular Biology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Neutrophils rapidly migrate to infection sites after the recognition of invaders. During chemotaxis, neutrophils require energy supplied by mitochondria oxidative phosphorylation (OXPHOS), whereas neutrophils rely heavily on glycolysis under normal conditions. Mitochondrial OXPHOS correlates with mitochondrial morphology. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.037DOI Listing

Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage.

Biochem Biophys Res Commun 2019 Apr 12. Epub 2019 Apr 12.

School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address:

Pellino1 is an E3 ubiquitin ligase that plays a key role in positive regulation of innate immunity signaling, specifically required for the production of interferon when induced by viral double-stranded RNA. We report the identification of the tumor suppressor protein, p53, as a binding partner of Pellino1. Their interaction has a K of 42 ± 2 μM and requires phosphorylation of Thr18 within p53 and association with the forkhead-associated (FHA) domain of Pellino1. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.095DOI Listing
April 2019
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Identification of a potent inhibitor of type II secretion system from Pseudomonas aeruginosa.

Biochem Biophys Res Commun 2019 Apr 12. Epub 2019 Apr 12.

Department of Experimental Biology, Wroclaw University of Environmental and Life Sciences, Ul. C. K. Norwida 27B, 50-375, Wroclaw, Poland; Faculty of Veterinary Medicine, Equine Clinic - Equine Surgery, Justus-Liebig-University, 35392, Giessen, Germany.

Pseudomonas aeruginosa is an opportunistic pathogen infecting human population. The pathogen is becoming a serious health problem due to its ability to evade normal immune response of the host and multiple drug resistance to many antibiotics. The pathogen has 2 major virulence systems of which the type III secretion system (T3SS) is of major concern to humans. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.055DOI Listing
April 2019
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Construction of small molecular CTLA4 analogs with CD80-binding affinity.

Biochem Biophys Res Commun 2019 Apr 12. Epub 2019 Apr 12.

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China. Electronic address:

A variety of CTLA4-Fc fusion proteins and anti-CTLA4 monoclonal antibody have been approved. Given the shortcomings of macromolecular antibodies, recombinant proteins derived from the tenth unit of human type III fibronectin (FN3) termed monobody were studied as CTLA4 analogs in this study. A peptide EL16 derived from CD80-binding domain (MYPPPY motifs) in the complementarity determining region (CDR) 3 of CTLA4 was found to inhibit the interaction of CTLA4 with CD80 significantly. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.041DOI Listing
April 2019
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Intra-individual variation and transcribed pseudogenes in the ribosomal ITS1-5.8S-ITS2 rDNA of Paraplagusia japonica (Pleuronectiformes: Cynoglossidae).

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510000, China; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou, 510000, China.

The eukaryotic ribosomal DNA (rDNA) cluster consists of multiple copies of three genes (18S, 5.8S, and 28S rDNA) and two internal transcribed spacers (ITS1 and ITS2). Typically, rDNA is thought to be evolved in a strict concerted evolution pattern, in which show little or even no variations within species, while sequence diversity between species or higher taxa. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.064DOI Listing
April 2019
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Protein interactome of the deamidase phosphoribosylformylglycinamidine synthetase (PFAS) by LC-MS/MS.

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

Department of Cell Biology, School of Life Sciences, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan, China. Electronic address:

Phosphoribosylformylglycinamidine synthase (PFAS) is an essential enzyme in de novo synthesis of purine. Previously, PFAS has been reported to modulate RIG-I activation during viral infection via deamidation. In this study, we sought to identify potential substrates that PFAS can deamidate. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.039DOI Listing

Intrauterine low-protein diet disturbs metanephric gene expression and induces urinary tract developmental abnormalities in mice.

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

Department of Nephrology, Children's Hospital of Fudan University, Shanghai Kidney Development and Pediatric Kidney Disease Research Center, Shanghai, China. Electronic address:

Intrauterine low-protein diet can affect kidney development and hence final nephron number. In this study, we reported that intrauterine low-protein diet can cause congenital anomalies of the kidney and urinary tract (CAKUT) phenotypes, which was dominated by the duplicated collecting system phenotype. At the same time, ectopic ureteric buds were increased under intrauterine low-protein diet and the number of UB branches was reduced in the serum-free culture. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.057DOI Listing
April 2019
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NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1β processing during Streptococcus pneumoniae infection.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

College of Animal Science and Technology, Southwest University, Chongqing, 400715, China. Electronic address:

Streptococcus pneumoniae is a pathogenic bacterium that can cause severe invasive diseases, such as pneumonia, otitis media and meningitis. The pro-inflammatory cytokine, IL-1β, has been reported to play important role in host defense against S. pneumoniae. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.004DOI Listing

Disruption of SpoIIID decreases sporulation, increases extracellular proteolytic activity and virulence in Bacillus anthracis.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing, 100071, China; College of Food Science and Technology, Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai Ocean University, No. 999, Huchenghuan Road, Shanghai, 201306, PR China. Electronic address:

Endospores are important for maintenance of the B. anthracis lifecycle and necessary for its effective spread between hosts. Our experiments with B. Read More

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Biodelivery of nerve growth factor and gold nanoparticles encapsulated in chitosan nanoparticles for schwann-like cells differentiation of human adipose-derived stem cells.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

The constant release of neurotrophic factors through a nanomaterial-based delivery system can be an important strategy in medical and pharmaceutical fields for nerve tissue engineering. The present study was aimed at encapsulating NGF and AuNPs in chitosan nanoparticles (NGF-CNPs and AuNPs-CSNPs) and its evaluation on the differentiation potential of human adipose-derived stem cells (h-ADSCs) to Schwann-like cells. The NGF-CNPs were prepared by ionotropic gelation method with tripolyphosphate (TPP) as a crosslinker. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.189DOI Listing

In vitro differentiation of mouse T cell-derived hybrid cells obtained through cell fusion with embryonic stem cells.

Biochem Biophys Res Commun 2019 Apr 12. Epub 2019 Apr 12.

Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, Japan. Electronic address:

Nuclear reprogramming is an innovative advance in cell biology. An important research initiative in this field is cell fusion-mediated nuclear reprogramming, wherein the nuclei of somatic cells, such as thymocytes, are initialized through cell fusion with embryonic stem cells (ESCs). However, hybrid cells obtained through cell fusion between ESCs and thymocytes failed to contribute to the embryo proper when injected into blastocysts, which suggested that there are fundamental defects in such hybrid cells. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.038DOI Listing

Long non-coding RNA MNX1-AS1 promotes hepatocellular carcinoma proliferation and invasion through targeting miR-218-5p/COMMD8 axis.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China. Electronic address:

Long noncoding RNAs (lncRNAs) are involved in tumorigenesis. Previously, lncRNA MNX1-AS1 was reported to increase the malignancy of ovarian cancer, cervical cancer and lung cancer. However, the potential function of MNX1-AS1 in hepatocellular carcinoma (HCC) remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.012DOI Listing
April 2019
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Ad5-EMC6 mediates antitumor activity in gastric cancer cells through the mitochondrial apoptosis pathway.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

Department of Immunology, Peking University School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, 100191, China. Electronic address:

Endoplasmic reticulum membrane protein complex subunit 6 (EMC6), also known as transmembrane protein 93 (transmembrane protein 93, TMEM93), is an autophagy-related protein. EMC6 overexpression inhibits cancer cell growth and induces apoptosis, but the interaction partners of EMC6 and its cellular responsibilities remain incompletely understood. In this study, we report that adenovirus-mediated ectopic overexpression of EMC6 (Ad5-EMC6) in BGC823 and SGC7901 gastric cancer cells decreases the activity of ERK1/2, down-regulates the levels of BCL-2 protein and phosphorylated BCL-2, increases the expression of tBID and BAX, and decreases mitochondrial membrane potential and subsequently leading to cell apoptosis. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.023DOI Listing

Fucoxanthin exerts anti-fibrogenic effects in hepatic stellate cells.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA; Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea. Electronic address:

The objective of this study was to evaluate whether fucoxanthin (FCX) have anti-fibrogenic properties in hepatic stellate cells (HSCs). FCX significantly decreased basal and transforming growth factor β1 (TGFβ1)-induced mRNA levels of fibrogenic genes with concomitant decreases in their protein levels in LX-2 cells. The phosphorylation of SMA- and MAD-related protein (SMAD3) was increased by TGFβ1, which was attenuated by FCX. Read More

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April 2019
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ROS/JNK/c-Jun axis is involved in oridonin-induced caspase-dependent apoptosis in human colorectal cancer cells.

Biochem Biophys Res Commun 2019 Apr 10. Epub 2019 Apr 10.

Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:

Colorectal cancer (CRC) is one of the most common malignant neoplasms with high mortality worldwide. Oridonin, a diterpenoid isolated from the Chinese medicinal herb Rabdosia rubescens, has been proved to have anticancer effect on various types of cancer cells. However, the detailed mechanisms of oridonin in CRC cells remain unclear and if oridonin can overcome 5-FU resistance have not been investigated yet. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.011DOI Listing

Structural basis for efonidipine block of a voltage-gated Ca channel.

Biochem Biophys Res Commun 2019 Apr 10. Epub 2019 Apr 10.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, 61004, China. Electronic address:

Efonidipine is a dual L-/T- type calcium channel blocker with a slow onset of action and a long lasting effect that exibihits antihypertensive and nephroprotective effects. differs from most other DHPs which can induce reflex tachycardia. Efonidipine reduces blood pressure without decreasing cardiac output and exerts organ-protective effects on the heart and kidney. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.176DOI Listing
April 2019
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Connexin 43-serine 282 modulates serine 279 phosphorylation in cardiomyocytes.

Biochem Biophys Res Commun 2019 Apr 10. Epub 2019 Apr 10.

Department of Pharmacology, Beijing Key Laboratory of Metabolic Disturbance Related Cardiovascular Disease, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China. Electronic address:

Connexin 43 (Cx43) phosphorylation plays a pivotal role in cardiac electrical and contractile performance. In a previous study we have found that Cx43 phosphorylation at serine 282 (pS282) regulates cardiomyocyte survival. Considering that both sites are altered simultaneously in many studies, we designed this study to identify the status of S279 phosphorylation upon pS282 manipulation. Read More

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April 2019
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Construction of an irreversible allergic rhinitis-induced olfactory loss mouse model.

Biochem Biophys Res Commun 2019 Apr 10. Epub 2019 Apr 10.

Department of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

Clinical data show that part of patients with sinonasal diseases suffered from olfactory dysfunction, especially with allergic rhinitis (AR) and chronic rhinosinusitis (CRS). However, the mechanisms responsible for AR-induced olfactory loss are still largely unknown. Because of the difficulty to obtain human olfactory mucosa, an AR-induced olfactory loss animal model needs to be constructed to clarify the mechanism. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.110DOI Listing
April 2019
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Nuclear receptor TLX regulates islet beta cell proliferation via E2F6.

Biochem Biophys Res Commun 2019 Apr 10. Epub 2019 Apr 10.

Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. Electronic address:

Both type 1 and type 2 diabetes are associated with loss of functional beta cell mass, and strategies to restore beta cells are urgently needed. We reported previously that overexpression of the nuclear receptor TLX induces beta cell proliferation, but the underlying molecular mechanism has not been defined. Here, we identified direct targets of TLX in beta cells at the genome-wide level by ChIP-Seq. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.033DOI Listing
April 2019
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Metabolomics profiling of haloperidol and validation of thromboxane-related signaling in the early development of zebrafish.

Biochem Biophys Res Commun 2019 Apr 10. Epub 2019 Apr 10.

Department of Chemistry, Chinese Culture University, Taipei, 11114, Taiwan. Electronic address:

Haloperidol is a common butyrophenone-derivative antipsychotic drug that is used clinically to treat schizophrenia and to control Tourette disorder. Haloperidol has been shown to be an embryonic toxicant and to cause a variety of adverse effects that affect human embryonic development. However, the pathway impaired by haloperidol during the developmental stages remains unclear. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.003DOI Listing