521 results match your criteria Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al[Journal]


MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins.

Cells 2020 May 11;9(5). Epub 2020 May 11.

Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.

Chromatin remodeling, including histone modification, chromatin (un)folding, and nucleosome remodeling, is a significant transcriptional regulation mechanism. By these epigenetic modifications, transcription factors and their regulators are recruited to the promoters of target genes, and thus gene expression is controlled through either transcriptional activation or repression. The -mediated transcriptional repressor (MMTR)/DNA methyltransferase 1 (DNMT1)-associated protein (Dmap1) is a transcription corepressor involved in chromatin remodeling, cell cycle regulation, DNA double-strand break repair, and tumor suppression. Read More

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http://dx.doi.org/10.3390/cells9051190DOI Listing

Public Interest in Textured Breast Implants Recall: A Google Trends Analysis.

Aesthetic Plast Surg 2020 Apr 30. Epub 2020 Apr 30.

Division of Plastic Surgery, Department of Surgery, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA, 94305, USA.

Background: Large-scale media coverage of health care outcomes can have a profound influence on health care utilization by the general population. Google trends (GT), an online resource, allows for tracking of global search volumes as a proxy for determining public interest.

Objective: To utilize GT to characterize measurable effects on public interest in breast implant removal procedures and breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) following March 2019 FDA Advisory Committee Meeting and July 2019 public statements by the FDA and Allergan announcing the voluntary recall of BIOCELL textured breast implants. Read More

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http://dx.doi.org/10.1007/s00266-020-01724-zDOI Listing

Effects of Microwave-Assisted Extract in Inhibiting the Impacts of Particulate Matter on Human Keratinocyte Skin Cell.

Antioxidants (Basel) 2020 Mar 25;9(4). Epub 2020 Mar 25.

Department of BioNano Technology, Gachon University, 1342 Seongnam-Daero, Sujeong-Gu, Seongnam-Si, Gyeonggi-do 13120, Korea.

Particulate matter (PM) is one of the most important factors causing serious skin diseases, due to its generation of reactive oxygen species (ROS) over the course of long-term exposure. As a source of natural antioxidants, () is a potential candidate for the design of advanced formulations to prevent PM's harmful effects. Unfortunately, its high viscosity does not allow it to be utilized in these formulations. Read More

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http://dx.doi.org/10.3390/antiox9040271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222191PMC

Evaluating the Necessity of Capsulectomy in Cases of Textured Breast Implant Replacement.

Authors:
Eric Swanson

Ann Plast Surg 2020 Feb 25. Epub 2020 Feb 25.

From the Swanson Center, Leawood, KS.

Background: Capsulectomy has traditionally been recommended as a treatment for capsular contracture after breast augmentation. With the advent of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL), and the Food and Drug Administration's decision to ban Biocell textured devices, this operation has taken on new importance. This review was undertaken to better inform clinical recommendations for women with textured devices. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002301DOI Listing
February 2020

Skin Toxicity Assessment of Silver Nanoparticles in a 3D Epidermal Model Compared to 2D Keratinocytes.

Int J Nanomedicine 2019 9;14:9707-9719. Epub 2019 Dec 9.

NCNST-NIFDC Joint Laboratory for Measurement and Evaluation of Nanomaterials in Medical Applications, National Institutes for Food and Drug Control, Beijing 102629, People's Republic of China.

Introduction: Increased use of silver nanoparticles (AgNPs) has raised concerns that AgNPs may induce toxic effects. In vitro studies of cell monolayers and in vivo studies have produced conflicting results. The inconsistency of these results has been mainly due to limitations of two-dimensional (2D) monolayer cell systems. Read More

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http://dx.doi.org/10.2147/IJN.S225451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910103PMC

Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia: A Longitudinal Study of Implant and Other Related Risk Factors.

Aesthet Surg J 2019 Nov 18. Epub 2019 Nov 18.

Peter MacCallum Cancer Center, Melbourne, Australia.

Background: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an emerging cancer that has been linked to the use of textured devices. Recent increase in number and frequency of cases has led to worldwide regulatory action.

Objective: We aimed to longitudinally study the disease in Australia since the index case was first reported in 2007. Read More

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http://dx.doi.org/10.1093/asj/sjz333DOI Listing
November 2019
4 Reads

The Food and Drug Administration Bans Biocell Textured Breast Implants: Lessons for Plastic Surgeons.

Authors:
Eric Swanson

Ann Plast Surg 2020 Apr;84(4):343-345

From the Swanson Center, Leawood, KS.

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http://dx.doi.org/10.1097/SAP.0000000000002139DOI Listing

Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Breast Implant Crisis.

Aesthetic Plast Surg 2020 02 17;44(1):1-12. Epub 2019 Oct 17.

Brazilian Society of Plastic Surgery, Curitiba, Brazil.

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon T-cell, CD-30+/ALK lymphoma. Late (9 years) periprosthetic fluid (seroma) is the most common presentation (90% of the cases). A combination of textured breast implant, bacterial contamination, and genetic predisposition seems to be necessary for BIA-ALCL to occur. Read More

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http://dx.doi.org/10.1007/s00266-019-01521-3DOI Listing
February 2020
2 Reads

Spindle pole body duplication defective yeast cells are more prone to membrane damage.

Mycologia 2019 Nov-Dec;111(6):895-903. Epub 2019 Oct 9.

Department of Bioengineering, Gebze Technical University, Gebze 41400, Kocaeli, Turkey.

Correct separation of chromosomes during mitosis is essential for preventing genetic instability and aneuploidy. Such separation is dependent on correct duplication of the nuclear-associated microtubular organizing center, i.e. Read More

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http://dx.doi.org/10.1080/00275514.2019.1659091DOI Listing

Plastic Surgeons Defend Textured Breast Implants at 2019 U.S. Food and Drug Administration Hearing: Why It Is Time to Reconsider.

Authors:
Eric Swanson

Plast Reconstr Surg Glob Open 2019 Aug 30;7(8):e2410. Epub 2019 Aug 30.

Swanson Center, Leawood, Kans.

Textured breast implants were the subject of a U.S. Food and Drug Administration (FDA) hearing on March 25 and 26, 2019. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756678PMC

[Thirty-six (36) French cases of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): What do we know about their prosthetic histories, and what conclusions may be drawn?]

Ann Chir Plast Esthet 2019 Aug 19;64(4):285-292. Epub 2019 Jul 19.

Service de chirurgie plastique esthétique et reconstructrice, centre hospitalo-universitaire de Strasbourg, hôpital de Hautepierre, avenue Molière, 67200 Strasbourg, France. Electronic address:

Introduction: Breast implant-associated anaplastic large cell lymphoma is a recent pathology; the one known risk factor is breast implantation.

Methods: A retrospective study was conducted on the French BIA-ALCL cases diagnosed by the Lymphopath network and reported to the National Medical Safety Agency (ANSM). Wishing to obtain supplementary data on the prosthetic history of implants, we sent the referent surgeons a questionnaire. Read More

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http://dx.doi.org/10.1016/j.anplas.2019.05.002DOI Listing
August 2019
12 Reads

Development of a new eczema-like reconstructed skin equivalent for testing child atopic dermatitis-relieving cosmetics.

J Cosmet Dermatol 2020 Mar 17;19(3):752-757. Epub 2019 Jul 17.

Pigeon Manufacturing (Shanghai) Co., Ltd., Shanghai, China.

Objective: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, and it has serious effects on children's and families' quality of life. We aimed to screen and evaluate the efficacy of different formulas on relieving of atopic dermatitis clinical symptoms by developing an eczema-like reconstructed human skin equivalent in vitro.

Method: Some research has reported that thymic stromal lymphopoietin (TSLP) may be a potential therapeutic target for the treatment of AD. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.13069
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http://dx.doi.org/10.1111/jocd.13069DOI Listing
March 2020
6 Reads

Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial.

Altern Ther Health Med 2019 Sep;25(5):12-29

Context: Dietary supplement manufacturers claim cutaneous anti-aging properties for their products; however, research supporting these claims remains sparse.

Objectives: The study intended to determine if a correlation existed between the effects of a collagen dietary supplement and changes associated with skin aging.

Design: The study was a 12-week, double-blind, placebo-controlled trial. Read More

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September 2019
5 Reads

Development of a new diaper dermatitis-like reconstructed skin equivalent for testing children atopic dermatitis relieving cosmetics.

Skin Res Technol 2019 Nov 19;25(6):839-845. Epub 2019 Jun 19.

Pigeon Manufacturing Shanghai Co., Ltd., Shanghai, China.

Background: Diaper dermatitis (DD) is the most common acute inflammatory skin disease. It has a serious effect on children's and families' quality of life. We aimed to screen and evaluate the efficacy of different formulas for relieving the diaper dermatitis symptoms by developing a kind of diaper dermatitis-like reconstructed human skin equivalent in vitro. Read More

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http://dx.doi.org/10.1111/srt.12731DOI Listing
November 2019
14 Reads

BioCell2XML: a novel tool for converting cell lineage data from SIMI BioCell to MaMuT (Fiji).

Dev Genes Evol 2019 07 22;229(4):137-145. Epub 2019 May 22.

Institut für Biologie, Vergleichende Zoologie, Humboldt-Universität zu Berlin, Philippstr 13, Haus 2, 10115, Berlin, Germany.

Computer-assisted 4D manual cell tracking has been a valuable method for understanding spatial-temporal dynamics of embryogenesis (e.g., Stach & Anselmi BMC Biol, 13(113), 1-11 2015; Vellutini et al. Read More

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http://link.springer.com/10.1007/s00427-019-00633-9
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http://dx.doi.org/10.1007/s00427-019-00633-9DOI Listing
July 2019
15 Reads

Clay Nanotubes Aligned with Shear Forces for Mesenchymal Stem Cell Patterning.

Small 2019 05 8;15(21):e1900357. Epub 2019 Apr 8.

Department of Materials Science and Engineering, Jinan University, Guangzhou, Guangdong, 510632, P. R. China.

Aligned halloysite nanotubes on solid substrates are fabricated by a shearing method with brush assistance. These clay nanotubes are aligned by shear force in strip-like patterns accomplished with drying ordering at elevated temperatures. The nanotubes' orientation is governed by "coffee-ring" formation mechanisms depending on the dispersion concentration, nanotube charge, and speed of thermos-evaporation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.2019003
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http://dx.doi.org/10.1002/smll.201900357DOI Listing
May 2019
26 Reads

Optical Coherence Tomography Investigations and Modeling of the Sintering of Ceramic Crowns.

Materials (Basel) 2019 Mar 21;12(6). Epub 2019 Mar 21.

Applied Optics Group, School of Physics, University of Kent, Canterbury CT2 7NR, UK.

Dental prostheses are sintered in ovens that sometimes suffer from a loss of calibration. This can lead to variations of the sintering temperature outside the range recommended by the manufacturer. Stress and even fractures in dental ceramics may occur, and this leads to the necessity to rebuild the dental construct. Read More

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http://dx.doi.org/10.3390/ma12060947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471312PMC
March 2019
4 Reads

The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants.

Plast Reconstr Surg Glob Open 2019 Feb 8;7(2):e2037. Epub 2019 Feb 8.

Division of Plastic & Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Mo.

Background: Bacterial contamination of breast implants causes infection, can lead to capsular contracture, and is implicated in breast implant-associated anaplastic large cell lymphoma. Bacteria, however, also colonize clinically benign breast implants and little is known about the biologic signals that trigger the switch from a benign to pathologic state.

Methods: Explanted smooth as well as Biocell and Siltex textured breast implants associated with clinically normal and pathologic conditions were analyzed in this observational study. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416121PMC
February 2019
5 Reads

Prothrombotic activity of cytokine-activated endothelial cells and shear-activated platelets in the setting of ventricular assist device support.

J Heart Lung Transplant 2019 06 18;38(6):658-667. Epub 2019 Feb 18.

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy; Advanced Heart Failure and Mechanical Circulatory Support Program, San Raffaele Scientific Institute, Milano, Italy; Università Vita Salute San Raffaele, Milano, Italy. Electronic address:

Background: We systematically analyzed the synergistic effect of: (i) cytokine-mediated inflammatory activation of endothelial cells (ECs) with and (ii) shear-mediated platelet activation (SMPA) as a potential contributory mechanism to intraventricular thrombus formation in the setting of left ventricular assist device (LVAD) support.

Methods: Intact and shear-activated human platelets were exposed to non-activated and cytokine-activated ECs. To modulate the level of LVAD-related shear activation, platelets were exposed to shear stress patterns of varying magnitude (30, 50, and 70 dynes/cm, 10 minutes) via a hemodynamic shearing device. Read More

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http://dx.doi.org/10.1016/j.healun.2019.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535357PMC
June 2019
6 Reads
6.650 Impact Factor

The Epidemiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia and New Zealand Confirms the Highest Risk for Grade 4 Surface Breast Implants.

Plast Reconstr Surg 2019 05;143(5):1285-1292

Macquarie Park and Sydney, New South Wales, and Melbourne, Victoria, Australia From Griffith University; the Australian Joint BIA-ALCL Task Force; Macquarie University; Monash University, Australian Breast Device Registry; the New Zealand Association of Plastic Surgeons; Epworth Healthcare, Sir Peter MacCallum Cancer Center and Department of Oncology, University of Melbourne; the Westmead Breast Cancer Institute, Breast Surgeons in Australia & New Zealand; and the Integrated Specialist Healthcare Education and Research Foundation.

Background: The epidemiology and implant-specific risk for breast implant-associated (BIA) anaplastic large cell lymphoma (ALCL) has been previously reported for Australia and New Zealand. The authors now present updated data and risk assessment since their last report.

Methods: New cases in Australia and New Zealand were identified and analyzed. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005500DOI Listing
May 2019
3 Reads

Adipose-Derived Stem Cell Coculturing Stimulates Integrin-Mediated Extracellular Matrix Adhesion of Melanocytes by Upregulating Growth Factors.

Biomol Ther (Seoul) 2019 Mar;27(2):185-192

Department of Dermatology, Dongguk University Ilsan Hospital, Goyang 10326, Republic of Korea.

Coculture with adipose-derived stem cells (ADSCs) can stimulate proliferation and migration of melanocytes. To enhance outcomes of skin disorders caused by melanocyte loss or death, mixed transplantation with ADSCs has been suggested. However, role of cocultured ADSCs in proliferation and migration of melanocytes remains unclear. Read More

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http://dx.doi.org/10.4062/biomolther.2018.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430229PMC
March 2019
3 Reads

Bacterial Adhesion and Biofilm Formation on Textured Breast Implant Shell Materials.

Aesthetic Plast Surg 2019 04 1;43(2):490-497. Epub 2018 Oct 1.

Keck School of Medicine, Division of Plastic Surgery, University of Southern California, Beverly Hills, CA, 90212, USA.

Background: Bacterial biofilms have been implicated with breast implant complications including capsular contracture and anaplastic large-cell lymphoma. The actual mechanisms for either are still under active investigation and are not clear. Due to their increased surface area, implants with textured surfaces may harbor greater biofilm loads than those with smooth surfaces. Read More

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http://dx.doi.org/10.1007/s00266-018-1234-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420479PMC
April 2019
27 Reads

Not All Breast Implants Are Equal: A 13-Year Review of Implant Longevity and Reasons for Explantation.

Plast Reconstr Surg 2018 09;142(3):281e-289e

Vancouver, British Columbia, Canada From the Division of Plastic Surgery, Department of Surgery, University of British Columbia.

Background: Augmentation mammaplasty is the most common aesthetic procedure. Textured implants control implant position and have improved capsular contracture rates; however, the impact of texturing on longevity and clinical findings at explantation is unclear.

Methods: All cases of explantation between January of 2005 and April of 2017 from an aesthetic practice were reviewed retrospectively. Read More

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http://dx.doi.org/10.1097/PRS.0000000000004678DOI Listing
September 2018
11 Reads

[Study on feasibility of HaCaT epidermal model as an alternative to skin irritation ].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 10;31(10):1262-1266

Guangdong Biocell Biotechnology Co. Ltd, Dongguan Guangdong, 523808, P.R.China.

Objective: To construct the epidermal model with HaCaT cells and evaluate the feasibility of this model as an skin irritation test tool.

Methods: The HaCaT model was reconstructed with HaCaT cells by adoption gas-liquid surface culture technique, and the EpiKutis model was reconstructed with human epidermal keratinocytes by the same techinique as control. Morphology changes of HaCaT and EpiKutis models were observed by HE staining. Read More

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http://dx.doi.org/10.7507/1002-1892.201705031DOI Listing
October 2017
15 Reads

Photocatalytic production of hydroxyl radicals by commercial TiO nanoparticles and phototoxic hazard identification.

Toxicology 2018 08 22;406-407:1-8. Epub 2018 May 22.

Guangdong Biocell Biotechnology, Ltd., Dongguan, Guangdong, 523888, China.

This study identifies the phototoxic potential of commercial titanium dioxide nanoparticles (TiO NPs) used in sunscreens and consumer products by employing a tiered testing approach comprising physicochemical, in vitro and ex vivo tests. Our results revealed that all the test samples of TiO NPs, varied in surface coating, crystallinity and primary particle size, produced hydroxyl radicals upon UVA photoexcitation as determined by electron spin resonance (ESR) spectroscopy. Their phototoxic potentials were assessed first by combining the validated 3T3 neutral red uptake phototoxicity test and red blood cell phototoxicity test and subsequently in ex vivo models of chick chorioallantoic membrane (CAM) and reconstructed human 3D skin model (H3D). Read More

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http://dx.doi.org/10.1016/j.tox.2018.05.010DOI Listing
August 2018
12 Reads

Real-Time Digital Bright Field Technology for Rapid Antibiotic Susceptibility Testing.

Methods Mol Biol 2018 ;1736:75-84

Philips BioCell A/S, Allerød, Denmark.

Optical scanning through bacterial samples and image-based analysis may provide a robust method for bacterial identification, fast estimation of growth rates and their modulation due to the presence of antimicrobial agents. Here, we describe an automated digital, time-lapse, bright field imaging system (oCelloScope, BioSense Solutions ApS, Farum, Denmark) for rapid and higher throughput antibiotic susceptibility testing (AST) of up to 96 bacteria-antibiotic combinations at a time. The imaging system consists of a digital camera, an illumination unit and a lens where the optical axis is tilted 6. Read More

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http://dx.doi.org/10.1007/978-1-4939-7638-6_7DOI Listing
December 2018
4 Reads

Capsular Biofilm Formation at the Interface of Textured Expanders and Human Acellular Dermal Matrix: A Comparative Scanning Electron Microscopy Study.

Plast Reconstr Surg 2018 04;141(4):919-928

Montreal, Quebec, Canada From the Plastic and Reconstructive Surgery Department, Notre-Dame Hospital, University of Montreal Hospital Center.

Background: Despite benefits in reducing capsular contractures, textured implants have been associated with significant pitfalls, such a propensity for biofilm formation. Few studies have investigated whether the use of acellular dermal matrix on textured implants produces similar findings. This study aims to characterize biofilm formation at the capsular-acellular dermal matrix interface with scanning electron microscopy. Read More

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http://dx.doi.org/10.1097/PRS.0000000000004216DOI Listing
April 2018
22 Reads

Automated time-lapse microscopy a novel method for screening of antibiotic combination effects against multidrug-resistant Gram-negative bacteria.

Clin Microbiol Infect 2018 Jul 3;24(7):778.e7-778.e14. Epub 2017 Nov 3.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Electronic address:

Objectives: Antibiotic combinations are often used for carbapenemase-producing Enterobacteriaceae (CPE) but more data are needed on the optimal selection of drugs. This study aimed to evaluate the feasibility of a novel automated method based on time-lapse microscopy (the oCelloScope, Philips BioCell A/S, Allerød, Denmark) to determine in vitro combination effects against CPE and to discuss advantages and limitations of the oCelloScope in relation to standard methods.

Methods: Four Klebsiella pneumoniae and two Escherichia coli were exposed to colistin, meropenem, rifampin and tigecycline, alone and in combination. Read More

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http://dx.doi.org/10.1016/j.cmi.2017.10.029DOI Listing
July 2018
8 Reads

Complete sequence-based pathway analysis by differential on-chip DNA and RNA extraction from a single cell.

Sci Rep 2017 09 8;7(1):11030. Epub 2017 Sep 8.

Philips Research Laboratories, High Tech Campus 11, 5656 AE, Eindhoven, The Netherlands.

We demonstrate on-chip, differential DNA and RNA extraction from a single cell using a microfluidic chip and a two-stage lysis protocol. This method enables direct use of the whole extract, without additional washing steps, reducing sample loss. Using this method, the tumor driving pathway in individual cells from a colorectal cancer cell line was determined by applying a Bayesian computational pathway model to sequences obtained from the RNA fraction of a single cell and, the mutations driving the pathway were determined by analyzing sequences obtained from the DNA fraction of the same single cell. Read More

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http://www.nature.com/articles/s41598-017-10704-4
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http://dx.doi.org/10.1038/s41598-017-10704-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591254PMC
September 2017
8 Reads

Enhanced polyhydroxyalkanoate (PHA) production from the organic fraction of municipal solid waste by using mixed microbial culture.

Biotechnol Biofuels 2017 22;10:201. Epub 2017 Aug 22.

Gruppo Ricicla labs-DiSAA-Università degli Studi di Milano, Via Celoria 2, 20133 Milan, Italy.

Background: In Europe, almost 87.6 million tonnes of food waste are produced. Despite the high biological value of food waste, traditional management solutions do not consider it as a precious resource. Read More

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http://dx.doi.org/10.1186/s13068-017-0888-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567430PMC
August 2017
29 Reads

Macrotextured Breast Implants with Defined Steps to Minimize Bacterial Contamination around the Device: Experience in 42,000 Implants.

Plast Reconstr Surg 2017 Sep;140(3):427-431

Dallas, Texas; Sydney, Toowoomba, and Gold Coast, Australia; Portland, Ore.; London, United Kingdom; and Stockholm, Sweden From the Department of Plastic Surgery, University of Texas Southwestern Medical Center; Macquarie University and Integrated Specialist Healthcare; private practice; Oregon Health Science University; and Royal Free Hospital.

Background: Bacteria/biofilm on breast implant surfaces has been implicated in capsular contracture and breast implant-associated anaplastic large-cell lymphoma (ALCL). Macrotextured breast implants have been shown to harbor more bacteria than smooth or microtextured implants. Recent reports also suggest that macrotextured implants are associated with a significantly higher incidence of breast implant-associated ALCL. Read More

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http://dx.doi.org/10.1097/PRS.0000000000003575DOI Listing
September 2017
33 Reads

Development of a Video-Microscopic Tool To Evaluate the Precipitation Kinetics of Poorly Water Soluble Drugs: A Case Study with Tadalafil and HPMC.

Mol Pharm 2017 12 16;14(12):4154-4160. Epub 2017 Aug 16.

Department of Pharmacy, University of Copenhagen , DK-2100 Copenhagen, Denmark.

Many drug candidates today have a low aqueous solubility and, hence, may show a low oral bioavailability, presenting a major formulation and drug delivery challenge. One way to increase the bioavailability of these drugs is to use a supersaturating drug delivery strategy. The aim of this study was to develop a video-microscopic method, to evaluate the effect of a precipitation inhibitor on supersaturated solutions of the poorly soluble drug tadalafil, using a novel video-microscopic small scale setup. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00422DOI Listing
December 2017
64 Reads

Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia and New Zealand: High-Surface-Area Textured Implants Are Associated with Increased Risk.

Plast Reconstr Surg 2017 Oct;140(4):645-654

Sydney, New South Wales; and Melbourne, Victoria, Australia From the Faculty of Medical and Health Sciences, Macquarie University; the Joint Breast Implant-Associated ALCL Task Force, American Society of Plastic Surgeons/American Society for Aesthetic Plastic Surgery/New Zealand Association of Plastic Surgeons; the Integrated Specialist Healthcare Education and Research Foundation; the Australian Breast Device Registry, Department of Epidemiology and Preventative Medicine, Monash University; and the Peter MacCallum Cancer Center.

Background: The association between breast implants and breast implant-associated anaplastic large cell lymphoma (ALCL) has been confirmed. Implant-related risk has been difficult to estimate to date due to incomplete datasets.

Methods: All cases in Australia and New Zealand were identified and analyzed. Read More

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http://dx.doi.org/10.1097/PRS.0000000000003654DOI Listing
October 2017
133 Reads
7 Citations
2.993 Impact Factor

High-Performance Respiration-Based Biocell Using Artificial Nanochannel Regulation.

Adv Mater 2017 Jun 24;29(24). Epub 2017 Apr 24.

State Key Laboratories of Natural and Mimetic Drugs and Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, P. R. China.

Based on electron and proton transfer events occurring in biological respiration, a mitochondria-based biocell is constructed by combining with artificial nanochannels. In this biocell, mitochondria transfer electrons to the working electrode and pump protons into the electrolyte through the tricarboxylic acid cycle. The nanochannels provide passages for protons to transport along the transmembrane concentration gradient to consume electrons on the counter electrode, forming a continuous and stable current. Read More

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http://dx.doi.org/10.1002/adma.201606871DOI Listing
June 2017
14 Reads

Human umbilical cord-derived mesenchymal stem cells in acute liver injury: Hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution.

Regul Toxicol Pharmacol 2016 Nov 28;81:437-447. Epub 2016 Sep 28.

Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Biomedical Center for Animal Resource and Development, Seoul National University College of Medicine, Seoul, Republic of Korea; Designed Animal and Transplantation Research Institute, Institute of GreenBio Science Technology, Seoul National University, Pyeongchang-gun, Gangwon-do, Republic of Korea. Electronic address:

Umbilical cord-derived mesenchymal stem cells (UC-MSCs) therapy might be an alternative to liver transplantation for acute or chronic liver injury. The aim of this study was to evaluate the efficacy of human UC-MSCs on carbon tetrachloride (CCl)-induced acute liver injury. In addition, its toxicity, tumorigenicity, and biodistribution were determined. Read More

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http://dx.doi.org/10.1016/j.yrtph.2016.09.029DOI Listing
November 2016
56 Reads
3 Citations
2.030 Impact Factor

Five-Year Outcomes of Breast Augmentation with Form-Stable Implants: Periareolar vs Transaxillary.

Aesthet Surg J 2017 Jan 30;37(1):46-56. Epub 2016 Sep 30.

Drs Benito-Ruiz and Manzano are plastic surgeons in private practice in Barcelona, Spain. Dr Salvador-Miranda is a general surgeon in private practice in Barcelona, Spain.

Background: Form-stable 410 implants have the potential advantage of maintaining their anatomic form thanks to the cohesiveness of the gel. Furthermore, Biocell texturing appears to maximize adhesion and to allow for implant immobility.

Objectives: To compare the rate of reoperations for transaxillary and periareolar approaches for breast augmentation. Read More

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http://dx.doi.org/10.1093/asj/sjw154DOI Listing
January 2017
10 Reads

Templated green synthesis of plasmonic silver nanoparticles in onion epidermal cells suitable for surface-enhanced Raman and hyper-Raman scattering.

Beilstein J Nanotechnol 2016 9;7:834-40. Epub 2016 Jun 9.

Danmarks Tekniske Universitet DTU, Department of Physics, 2800 Kgs. Lyngby, Denmark.

We report fast and simple green synthesis of plasmonic silver nanoparticles in the epidermal cells of onions after incubation with AgNO3 solution. The biological environment supports the generation of silver nanostructures in two ways. The plant tissue delivers reducing chemicals for the initial formation of small silver clusters and their following conversion to plasmonic particles. Read More

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http://dx.doi.org/10.3762/bjnano.7.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979762PMC
August 2016
10 Reads

Propagation of the change in the membrane potential using a biocell-model.

Phys Chem Chem Phys 2016 05 20;18(18):12689-95. Epub 2016 Apr 20.

Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606-8502, Japan.

A new model system of nerve conduction, which has two sites (the potential-sending and the potential-receiving sites) was constructed by the use of some liquid-membrane cells which mimic the function of the K(+) and Na(+) channels. The model system setup was such that the membrane potential of the K(+)-channel cell (resting potential) was different from that of the Na(+)-channel cell (action potential). Initially, the K(+)-channel cell at the potential-sending site was connected to that at the potential-receiving site. Read More

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http://dx.doi.org/10.1039/c5cp07446kDOI Listing
May 2016
14 Reads

Unraveling the role of mechanical stimulation on smooth muscle cells: A comparative study between 2D and 3D models.

Biotechnol Bioeng 2016 10 28;113(10):2254-63. Epub 2016 Mar 28.

Laboratory for Biomaterials and Bioengineering, Department of Min-Met-Materials and CHU de Québec Research Center, Laval University, Quebec City, QC, Canada.

A thorough understanding of cell response to combined culture configuration and mechanical cues is of paramount importance in vascular tissue engineering applications. Herein, we investigated and compared the response of vascular smooth muscle cells (vSMCs) cultured in different culture environments (2D cell monolayers and 3D cellularized collagen-based gels) in combination with mechanical stimulation (7% uniaxial cyclic strain, 1 Hz) for 2 and 5 days. When cyclic strain was applied, two different responses, in terms of cell orientation and expression of contractile-phenotype proteins, were observed in 2D and 3D models. Read More

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http://doi.wiley.com/10.1002/bit.25979
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http://dx.doi.org/10.1002/bit.25979DOI Listing
October 2016
3 Reads

Evaluation of the Effects of BioCell Collagen, a Novel Cartilage Extract, on Connective Tissue Support and Functional Recovery From Exercise.

Integr Med (Encinitas) 2015 Jun;14(3):30-8

BioCell Technology LLC in Newport Beach, California.

Context: Little is known about the effect of nutritional supplementation on metabolic optimization for enhancing adaptation and recovery of the connective tissue elements that support musculoskeletal function.

Objective: The study aimed to determine the potential effect of supplementation with a novel, hydrolyzed chicken sternal cartilage extract-called BioCell Collagen-on biomarkers and functional indices of recovery from intense exercise.

Design: The research team designed a randomized, double-blind, placebo-controlled pilot study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566464PMC
June 2015
83 Reads

Characterization of Breast Implant Surfaces, Shapes, and Biomechanics: A Comparison of High Cohesive Anatomically Shaped Textured Silicone, Breast Implants from Three Different Manufacturers.

Aesthetic Plast Surg 2016 Feb 8;40(1):89-97. Epub 2016 Jan 8.

Akademikliniken, Storängsvägen 10, 11542, Stockholm, Sweden.

Unlabelled: Several companies offer anatomically shaped breast implants but differences among manufacturers are often misunderstood. The shell texture is a crucial parameter for anatomically shaped implants to prevent rotation and to decrease the risk of capsular contracture, even though concerns have recently been raised concerning the complications associated with textured breast implants. The aim of this study was to characterize differences in terms of texture, cell adhesion, shape, and stiffness between some commonly used anatomically shaped implants from three different manufacturers. Read More

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http://link.springer.com/10.1007/s00266-015-0603-8
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http://dx.doi.org/10.1007/s00266-015-0603-8DOI Listing
February 2016
88 Reads

Real-time monitoring of fungal inhibition and morphological changes.

J Microbiol Methods 2015 Dec 2;119:196-202. Epub 2015 Nov 2.

Department of Food Science, Faculty of Science, University of Copenhagen, Frederiksberg C, Denmark.

Mold growth constitutes a problem in many food and clinical environments and there is therefore focus on studying antifungal activity. Methods for determining growth inhibition by measuring colony growth or biomass are, however, time-taking and rapid methods for evaluation of antifungal effects are needed. Propionic acid and diacetyl are antifungal compounds produced by a range of dairy-associated bacteria. Read More

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http://dx.doi.org/10.1016/j.mimet.2015.10.024DOI Listing
December 2015
2 Reads

Automated image analysis for quantification of filamentous bacteria.

BMC Microbiol 2015 Nov 4;15:255. Epub 2015 Nov 4.

Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 49, 9000, Aalborg, Denmark.

Background: Antibiotics of the β-lactam group are able to alter the shape of the bacterial cell wall, e.g. filamentation or a spheroplast formation. Read More

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http://dx.doi.org/10.1186/s12866-015-0583-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632676PMC
November 2015
5 Reads

Systematic Effect for an Ultralong Cycle Lithium-Sulfur Battery.

Nano Lett 2015 Nov 30;15(11):7431-9. Epub 2015 Oct 30.

Beijing Key Laboratory of Environmental Science and Engineering, School of Material Science & Engineering, Beijing Institute of Technology , Beijing 100081, China.

Rechargeable lithium-sulfur (Li-S) batteries are attractive candidates for energy storage devices because they have five times the theoretical energy storage of state-of-the-art Li-ion batteries. The main problems plaguing Li-S batteries are poor cycle life and limited rate capability, caused by the insulating nature of S and the shuttle effect associated with the dissolution of intermediate lithium polysulfides. Here, we report the use of biocell-inspired polydopamine (PD) as a coating agent on both the cathode and separator to address these problems (the "systematic effects"). Read More

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http://pubs.acs.org/doi/10.1021/acs.nanolett.5b02864
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http://dx.doi.org/10.1021/acs.nanolett.5b02864DOI Listing
November 2015
26 Reads

Rapid antimicrobial susceptibility testing of clinical isolates by digital time-lapse microscopy.

Eur J Clin Microbiol Infect Dis 2015 Dec 25;34(12):2385-94. Epub 2015 Sep 25.

Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 49, 9000, Aalborg, Denmark.

Rapid antimicrobial susceptibility testing (AST) is essential for early and appropriate therapy. Methods with short detection time enabling same-day treatment optimisation are highly favourable. In this study, we evaluated the potential of a digital time-lapse microscope system, the oCelloScope system, to perform rapid AST. Read More

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http://dx.doi.org/10.1007/s10096-015-2492-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655009PMC
December 2015
2 Reads

The impact of postoperative expansion initiation timing on breast expander capsular characteristics: a prospective combined clinical and scanning electron microscopy study.

Plast Reconstr Surg 2015 Apr;135(4):967-74

Montreal, Quebec, Canada From the Division of Plastic and Reconstructive Surgery, University of Montreal Hospital Center, and the Department of Chemical Engineering, École Polytechnique, Université de Montréal.

Background: In the first stage of expander-to-implant breast reconstruction, postoperative expansion is classically initiated at 10 to 14 days (conventional approach). The authors hypothesized that it may be beneficial to wait 6 weeks postoperatively before initiating serial expansion (delayed approach). Clinical and ultrastructural periprosthetic capsule analysis is first required before determining whether a delayed approach ultimately improves capsular tissue adherence and expansion process predictability. Read More

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http://dx.doi.org/10.1097/PRS.0000000000001126DOI Listing
April 2015
27 Reads

Adipose-derived stem cells improve efficacy of melanocyte transplantation in animal skin.

Biomol Ther (Seoul) 2014 Jul;22(4):328-33

Departments of Dermatology, Dongguk University Ilsan Hospital, Goyang 410-773.

Vitiligo is a pigmentary disorder induced by a loss of melanocytes. In addition to replacement of pure melanocytes, cocultures of melanocytes with keratinocytes have been used to improve the repigmentation outcome in vitiligo treatment. We previously identified by in vitro studies, that adipose-derived stem cells (ADSCs) could be a potential substitute for keratinocytes in cocultures with melanocytes. Read More

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http://dx.doi.org/10.4062/biomolther.2014.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131530PMC
July 2014
18 Reads

Benefits and Limitations of Macrotextured Breast Implants and Consensus Recommendations for Optimizing Their Effectiveness.

Aesthet Surg J 2014 Aug 1;34(6):876-81. Epub 2014 Aug 1.

Dr Hedén is an Associate Professor of Plastic Surgery at Akademikliniken, Stockholm, Sweden.

Implant texture is an important factor influencing implant selection for breast augmentation. Natrelle Biocell implants are characterized by macrotextured shell surfaces containing irregularly arranged concavities with large open-pore diameters and depths. These properties facilitate adhesion of the implant to the surrounding tissue, thereby promoting implant immobilization. Read More

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http://dx.doi.org/10.1177/1090820X14538635DOI Listing
August 2014
17 Reads

Natrelle round silicone breast implants: Core Study results at 10 years.

Plast Reconstr Surg 2014 Jun;133(6):1354-61

Washington, D.C.; and Santa Barbara, Calif. From the Department of Plastic Surgery, Georgetown University Hospital; and Allergan, Inc.

Background: Allergan's Natrelle round silicone-filled breast implants were approved by the U.S. Food and Drug Administration in 2006 based on interim results from the Core Study; final 10-year study results are now available. Read More

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http://dx.doi.org/10.1097/PRS.0000000000000021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819531PMC
June 2014
10 Reads