14,663 results match your criteria BioSystems [Journal]


Gallstone formation as an example of the two-step space confined aggregation process.

Authors:
Jacek Siódmiak

Biosystems 2018 Dec 12. Epub 2018 Dec 12.

Institute of Mathematics and Physics, UTP University of Science and Technology, Al. Prof. S. Kaliskiego 7, 85-796 Bydgoszcz, Poland. Electronic address:

Gallstone disease and in particular its cholesterol type is one of the most common diseases of the digestive system. More than 10% of the population is affected by this disease and in the case of Native Indians of Peru and Chile this rate reaches as much as 100%. While the disease is well-researched from a medical point of view, the two-step mechanism of formation of gallstones is not well studied. Read More

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December 2018

Magnetic-core@dual-functional-shell nanocomposites with peroxidase mimicking properties for use in colorimetric and electrochemical sensing of hydrogen peroxide.

Mikrochim Acta 2018 Dec 14;186(1):20. Epub 2018 Dec 14.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.

A self-sacrificing catalytic method is described for the preparation of magnetic core/dual-functional-shell nanocomposites composed of magnetite, gold and Prussian Blue (type FeO@Au-PB). Two reaction pathways are integrated. The first involves chemical dissolution of FeO (the self-sacrificing step) by acid to release ferrous ions which then reacts with hexacyanoferrate(IV) to generate PB in the proximity of the magntic nanoparticles (MNPs). Read More

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December 2018

DEPArray™ system: An automatic image-based sorter for isolation of pure circulating tumor cells.

Cytometry A 2018 Dec;93(12):1260-1266

Menarini Silicon Biosystems S.p.A, Bologna, Italy.

Circulating tumor cells (CTCs) are rare cells shed into the bloodstream by invasive tumors and their analysis offers a promising noninvasive tool to predict and monitor therapeutic responses. CTCs can be isolated from patient blood and their characterization at single-cell level can inform on the genomic landscape of a tumor. All CTC enrichment methods bear a burden of contaminating normal cells, which mandate a further step of purification to enable reliable downstream genetic analysis. Read More

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December 2018
1 Read

Investigating the physiological mechanisms underlying Salicornia ramosissima response to atmospheric CO enrichment under coexistence of prolonged soil flooding and saline excess.

Plant Physiol Biochem 2018 Dec 6;135:149-159. Epub 2018 Dec 6.

Departamento de Biología Vegetal y Ecología, Facultad de Biología, Universidad de Sevilla, 1095, 41080, Sevilla, Spain.

A 45-days long climatic chamber experiment was design to evaluate the effect of 400 and 700 ppm atmospheric CO treatments with and without soil water logging in combination with 171 and 510 mM NaCl in the halophyte Salicornia ramosissima. In order to ascertain the possible synergetic impact of these factors associate to climatic change in this plant species physiological and growth responses. Our results indicated that elevated atmospheric CO concentration improved plant physiological performance under suboptimal root-flooding and saline conditions plants. Read More

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December 2018
1 Read

A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell's photodynamic therapy (PDT).

J Photochem Photobiol B 2018 Dec 5;190:146-153. Epub 2018 Dec 5.

Biosystems Group, Institute of Automatic Control, Silesian University of Technology, Akademicka 16, 44-100 Gliwice, Poland; Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100 Gliwice, Poland. Electronic address:

Zn-based phthalocyanine acts as drug or photosensitizer in photodynamic therapy (PDT) for the treatment of cancer cells. The activated zinc octacarboxyphthalocyanine (ZnPcOC) reacts with oxygen, to generate reactive oxygen species for the damage of melanoma cancer cells, Me45. This in vitro study aimed at investigating the cytotoxic effects of different concentrations of ZnPcOC activated with a diode laser (λ = 685 nm) on Me45, and normal human fibroblast cells, NHDF. Read More

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December 2018

[The role of fraction analysis of ferritin in diagnostic of secondary hemophagocyte syndrome].

Klin Lab Diagn 2018 ;63(1):21-27

The Federal state budget educational institution of higher education "The Pavlov First Saint Petersburg State Medical University" of Minzdrav of Russia, 197022, St. Petersburg, Russia.

The secondary hemophagocytic syndrome is a life-threatening condition characterized by non-specifc manifestations: systemic inflammatory reaction, cytopenia, liver affection, high content of ferritin in blood serum. One of manifestations of secondary hemophagocytic syndrome is decreasing of level of glycated ferritin in blood serum expressed in percentage of total level. The detection of glycated ferritin can be applied for a differentiated diagnosis with cli9nically similar conditions, including septic process. Read More

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January 2018

Live single cell mass spectrometry reveals cancer-specific metabolic profiles of circulating tumor cells.

Cancer Sci 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo, Japan.

Recently, there has been an increased attention to circulating tumor cells (CTCs) analysis, also known as liquid biopsy, owing to its potential benefits in cancer diagnosis and treatment. CTCs are released from primary tumor lesions into the blood stream and eventually metastasize to distant body organs. However, a major hurdle with CTC analysis is their natural scarcity. Read More

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December 2018

Exosome isolation and purification via hydrophobic interaction chromatography using a polyester, capillary-channeled polymer fiber phase.

Electrophoresis 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemistry, Biosystems Research Complex, Clemson University, Clemson, SC, 29634.

Extracellular vesicles, including microvesicles and exosomes, are lipidic membrane-derived vesicles that are secreted by most cell types. Exosomes, one class of these vesicles that are 30-100 nm in diameter, hold a great deal of promise in disease diagnostics, as they display the same protein biomarkers as their originating cell. For exosomes to become useful in disease diagnostics, and as burgeoning drug delivery platforms, they must be isolated efficiently and effectively without compromising their structure. Read More

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December 2018

Co-Encapsulation of EGCG and Quercetin in Liposomes for Optimum Antioxidant Activity.

J Food Sci 2018 Dec 12. Epub 2018 Dec 12.

College of Biosystems Engineering and Food Science, Zhejiang Univ., Hangzhou, 310058, Zhejiang, China.

Although different delivery systems have been developed to overcome the limits of Epigallocatechin-3-gallate (EGCG) and quercetin in food application, none have referred to their simultaneous encapsulation. In this study, these two polyphenols were successfully co-loaded into liposomes. Under the optimal conditions (lecithin-total polyphenols ratio 25:1, lecithin-cholesterol ratio 6:1, lecithin-Tween 80 ratio 8:1 and ultrasonic time 2 min), the mean size, polydispersity index (PDI) and zeta potential of liposomes were 111. Read More

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December 2018

Epidermal Growth Factor-Releasing Radially Aligned Electrospun Nanofibrous Patches for the Regeneration of Chronic Tympanic Membrane Perforations.

Adv Healthc Mater 2018 Dec 12:e1801160. Epub 2018 Dec 12.

Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-742, Republic of Korea.

Chronic tympanic membrane (TM) perforations can cause otorrhea. To date, various types of tissue engineering techniques have been applied for the regeneration of chronic TM perforations. However, the application of nanofibers with radially aligned nanostructures and the simultaneous release of growth factors have never been applied in the regeneration of chronic TM perforations. Read More

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December 2018

High-Yield and Damage-free Exfoliation of Layered Graphdiyne in Aqueous Phase.

Angew Chem Int Ed Engl 2018 Dec 7. Epub 2018 Dec 7.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, the Chinese, Academy of Sciences (CAS), Beijing, 100190, China.

The two-dimensional carbon material graphdiyne (GDY) holds great promise as a semiconductor and porous material, however, exfoliation of bulk GDY into single- or few-layered GDY in the aqueous phase remains a challenge. We report an efficient method for the damage-free exfoliation of bulk GDY into single- or few-layered GDY with high yield in an aqueous solution of inorganic salts (e.g. Read More

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December 2018

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice.

Geroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, 4700 Old Main Hill, Logan, UT, 84322, USA.

Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Read More

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December 2018

Increases in cytosolic Ca induce dynamin- and calcineurin-dependent internalisation of CFTR.

Cell Mol Life Sci 2018 Dec 13. Epub 2018 Dec 13.

Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated, apical anion channel that regulates ion and fluid transport in many epithelia including the airways. We have previously shown that cigarette smoke (CS) exposure to airway epithelia causes a reduction in plasma membrane CFTR expression which correlated with a decrease in airway surface hydration. The effect of CS on CFTR was dependent on an increase in cytosolic Ca. Read More

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December 2018
1 Read

A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells.

Oncotarget 2018 Nov 16;9(90):36110-36125. Epub 2018 Nov 16.

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore.

The reciprocal interaction between circulating tumor cells (CTCs) and tissue-specific cells is influential for the progression of metastases. In particular, the process of extravasation relies on the complex cross-talk between cancer cells and other cellular players such as the endothelium and the secondary tissue. However, most studies only focus on one heterotypic cell-cell interaction and often lack of physiological relevance. Read More

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November 2018

Magnetic Nanoparticle-Based Biosensing Assay Quantitatively Enhances Acid-Fast Bacilli Count in Paucibacillary Pulmonary Tuberculosis.

Biosensors (Basel) 2018 Dec 12;8(4). Epub 2018 Dec 12.

Global Alliance for Rapid Diagnostics. Michigan State University, East Lansing, MI 48824, USA.

A new method using a magnetic nanoparticle-based colorimetric biosensing assay (NCBA) was compared with sputum smear microscopy (SSM) for the detection of pulmonary tuberculosis (PTB) in sputum samples. Studies were made to compare the NCBA against SSM using sputum samples collected from PTB patients prior to receiving treatment. Experiments were also conducted to determine the appropriate concentration of glycan-functionalized magnetic nanoparticles (GMNP) used in the NCBA and to evaluate the optimal digestion/decontamination solution to increase the extraction, concentration and detection of acid-fast bacilli (AFB). Read More

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December 2018

Hyperspectral Image-Based Variety Classification of Waxy Maize Seeds by the t-SNE Model and Procrustes Analysis.

Sensors (Basel) 2018 Dec 11;18(12). Epub 2018 Dec 11.

College of Automation, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.

Variety classification is an important step in seed quality testing. This study introduces t-distributed stochastic neighbourhood embedding (t-SNE), a manifold learning algorithm, into the field of hyperspectral imaging (HSI) and proposes a method for classifying seed varieties. Images of 800 maize kernels of eight varieties (100 kernels per variety, 50 kernels for each side of the seed) were imaged in the visible- near infrared (386. Read More

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December 2018

Feasibility of attenuated total reflection-fourier transform infrared (ATR-FTIR) chemical imaging and partial least squares regression (PLSR) to predict protein adhesion on polymeric surfaces.

Analyst 2018 Dec 13. Epub 2018 Dec 13.

School of Biosystems and Food Engineering, University College Dublin, Belfield, Dublin 4, Ireland.

Predicting the degree to which proteins adhere to a polymeric surface is an ongoing challenge in the scientific community to prevent non-specific protein adhesion and drive favourable protein - surface interactions. This work explores the potential of multivariate PLSR modelling in conjunction with Attenuated Total Reflection - Fourier Transform Infrared (ATR-FTIR) chemical imaging to investigate whether experimentally characterised surface chemistry can be used to predict surface protein adhesion. ATR-FTIR spectra were collected on dry and wetted polymeric surfaces, followed by evaluation of adhered fibrinogen on surfaces using the micro bicinchoninic (BCA) protein assay as a reference method. Read More

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December 2018

risks due to consumption of aquaculture-produced shrimp.

Microb Risk Anal 2018 Aug 13;9:22-32. Epub 2018 Apr 13.

Department of Civil, Architectural, and Environmental Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104.

The use of aquaculture is increasing to meet the growing global demand for seafood. However, the use of aquaculture for seafood production incurs potential human health risks, especially from enteric bacteria such as spp. spp. Read More

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Healthy Food as a New Technology-The Implications of Technological Diffusion and Food Price for Changes in Eating Habits.

Front Nutr 2018 22;5:109. Epub 2018 Nov 22.

Department of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA, United States.

Diet influences health and poor diets drive up healthcare costs for individuals and society as a whole. Multiple governmental programs in the US have aimed to educate citizens about diet choices, resulting in documented successes, as well as, unintended consequences such as increased food waste. Here we examine some of the relationships between healthy diets, food prices, and wealth by drawing parallels between the diffusion of technological innovation and healthy food diets. Read More

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November 2018

New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes.

Front Chem 2018 15;6:538. Epub 2018 Nov 15.

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.

sp. UR22 and sp. UR66, two actinomycetes derived from the Red Sea sponge , were co-cultured and the induced metabolites were monitored by HPLC-DAD and TLC. Read More

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November 2018

CASMAP: Detection of statistically significant combinations of SNPs in association mapping.

Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.

Department of Biosystems Science and Engineering, ETH Zurich, Basel, 4058, Switzerland SIB Swiss Institute of Bioinformatics.

Summary: Combinatorial association mapping aims to assess the statistical association of higher-order interactions between genetic markers with a phenotype of interest. This paper presents CASMAP, a software package that leverages recent advances in significant pattern mining to overcome the statistical and computational challenges that have hindered combinatorial association mapping. CASMAP can be used to perform region-based association studies and to detect higher-order epistatic interactions of genetic variants. Read More

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December 2018

Spatial impacts of a multi-individual grave on microbial and microfaunal communities and soil biogeochemistry.

PLoS One 2018 12;13(12):e0208845. Epub 2018 Dec 12.

Department of Biosystems Engineering and Soil Science, University of Tennessee, Knoxville, Tennessee, United States of America.

Decomposing vertebrates, including humans, result in pronounced changes in surrounding soil biogeochemistry, particularly nitrogen (N) and carbon (C) availability, and alter soil micro- and macrofauna. However, the impacts of subsurface human decomposition, where oxygen becomes limited and microbial biomass is generally lower, are far less understood. The goals of this study were to evaluate the impact of human decomposition in a multi-individual, shallow (~70 cm depth) grave on soil biogeochemistry and soil microbial and nematode communities. Read More

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December 2018

A New Phylogenetic Framework for the Animal-Adapted Complex.

Front Microbiol 2018 27;9:2820. Epub 2018 Nov 27.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Tuberculosis (TB) affects humans and other animals and is caused by bacteria from the complex (MTBC). Previous studies have shown that there are at least nine members of the MTBC infecting animals other than humans; these have also been referred to as ecotypes. However, the ecology and the evolution of these animal-adapted MTBC ecotypes are poorly understood. Read More

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November 2018
1 Read

Root mediated uptake of Salmonella is different from phyto-pathogen and associated with the colonization of edible organs.

BMC Plant Biol 2018 Dec 11;18(1):344. Epub 2018 Dec 11.

Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.

Background: Pre-harvest contamination of fruits and vegetables by Salmonella in fields is one of the causes of food-borne outbreaks. Natural openings like stomata, hydathodes and fruit cracks are known to serve as entry points. While there are reports indicating that Salmonella colonize and enter root through lateral root emerging area, further investigations regarding how the accessibility of Salmonella to lateral root is different from phyto-pathogenic bacteria, the efficacy of lateral root to facilitate entry have remained unexplored. Read More

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December 2018

Near IR Photochemistry for Biology: Exploiting the Optical Window of Tissue.

Photochem Photobiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Chemistry, Massachusetts Institute of Technology.

Photoactive molecules enable much of modern biology and biochemistry - a vast library of fluorescent chromophores is used to track and label cellular structures and macromolecules. However, photochemistry is better-known to the synthetic or physical organic chemist as a "light switch" that turns on unusual excited-state reactivity, isomerization, or dynamic adjustment of structure. This review details a rapidly growing approach to bio-photochemistry that uses low-energy near-IR wavelengths not only for imaging, but for close spatial control over chemical switching events in biosystems. Read More

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December 2018
1 Read

Identification of temperature-sensitive mutations and characterization of thermolabile RNase II variants.

FEBS Lett 2018 Dec 8. Epub 2018 Dec 8.

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.

The RNase II family of ribonucleases is ubiquitous and critical for RNA metabolism. The rnb500 allele has been widely used for over 30 years; however, the underlying genetic changes which result in RNase II thermolabile activity remain unknown. Here, we combine molecular and biophysical studies to carry out an in vivo and in vitro investigation of RNase II mutation(s) that confer the rnb500 phenotype. Read More

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December 2018

Effects of litter floor access and inclusion of experienced hens in aviary housing on floor eggs, litter condition, air quality, and hen welfare.

Poult Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Veterinary Diagnostic & Production Animal Medicine, Iowa State University, Ames 5011-1134, IA, USA.

With different cage-free (CF) housing styles and management schemes, retailers have developed their own CF criteria. One highly debated aspect is if hens may be kept inside the system for part of the day-during the first few hours after lights-on. Research is lacking regarding the impacts of such a practice on hen welfare, incidence of eggs laid on the litter floor, litter condition, and air quality. Read More

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December 2018
1 Read

The sickle cell trait affects contact dynamics and endothelial cell activation in -infected erythrocytes.

Commun Biol 2018 30;1:211. Epub 2018 Nov 30.

1Department of Infectious Diseases, Parasitology, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

Sickle cell trait, a common hereditary blood disorder, protects carriers from severe disease in infections with the human malaria parasite . Protection is associated with a reduced capacity of parasitized erythrocytes to cytoadhere to the microvascular endothelium and cause vaso-occlusive events. However, the underpinning cellular and biomechanical processes are only partly understood and the impact on endothelial cell activation is unclear. Read More

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November 2018
1 Read

Complete Genome Sequence of the Soil Bacterium Strain 46-2.

Microbiol Resour Announc 2018 Nov 29;7(21). Epub 2018 Nov 29.

Synthetic Biology and Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.

Pseudomonas kribbensis is a novel species belonging to the Pseudomonas fluorescens intrageneric group of the genus Pseudomonas. Herein, we report the complete genome sequence of strain 46-2, isolated from garden soil in Daejeon, South Korea. The 6. Read More

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November 2018
1 Read

Genome Sequence of the Wine Yeast UTAD17.

Microbiol Resour Announc 2018 Nov 8;7(18). Epub 2018 Nov 8.

Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

This work describes, for the first time, the genome sequence of a Saccharomycodes ludwigii strain. Although usually seen as a wine spoilage yeast, S. ludwigii has been of interest for the production of fermented beverages because it harbors several interesting properties, including the production of beneficial aroma compounds. Read More

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November 2018

Complete Genome Sequence of Bacillus subtilis Strain WB800N, an Extracellular Protease-Deficient Derivative of Strain 168.

Microbiol Resour Announc 2018 Nov 8;7(18). Epub 2018 Nov 8.

Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon, Republic of Korea.

Bacillus subtilis WB800N is a genetically engineered variant of B. subtilis 168, such that all extracellular proteases are disrupted, which enables WB800N to be widely used for the expression of secretory proteins. Here, we report the 4. Read More

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November 2018
1 Read

Draft Genome Sequences of the 1,2-Dichloropropane-Respiring Dehalococcoides mccartyi Strains RC and KS.

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.

Dehalococcoides mccartyi strains RC and KS respire toxic 1,2-dichloropropane to environmentally benign propene. Their genomes were sequenced with Ion Torrent technology, assembled, and annotated. The draft genomes of strains RC and KS were 1. Read More

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September 2018

Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.

J Oncol 2018 8;2018:6301980. Epub 2018 Nov 8.

Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil.

Introduction: Differential expression of genes encoding cytochrome P450 (CYP) and other oxygenases enzymes involved in biotransformation mechanisms of endogenous and exogenous compounds can lead to oral tumor development.

Objective: We aimed to identify the expression profile of these genes, searching for susceptibility biomarkers in oral squamous cell carcinoma.

Patients And Methods: Sixteen oral squamous cell carcinoma samples were included in this study (eight tumor and eight adjacent non-tumor tissues). Read More

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November 2018

Identifying disease genes using machine learning and gene functional similarities, assessed through Gene Ontology.

PLoS One 2018 10;13(12):e0208626. Epub 2018 Dec 10.

LASIGE, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.

Identifying disease genes from a vast amount of genetic data is one of the most challenging tasks in the post-genomic era. Also, complex diseases present highly heterogeneous genotype, which difficult biological marker identification. Machine learning methods are widely used to identify these markers, but their performance is highly dependent upon the size and quality of available data. Read More

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December 2018

Closing the gap between palaeontological and neontological speciation and extinction rate estimates.

Nat Commun 2018 12 7;9(1):5237. Epub 2018 Dec 7.

Swiss Institute of Bioinformatics (SIB), 1015, Lausanne, Switzerland.

Measuring the pace at which speciation and extinction occur is fundamental to understanding the origin and evolution of biodiversity. Both the fossil record and molecular phylogenies of living species can provide independent estimates of speciation and extinction rates, but often produce strikingly divergent results. Despite its implications, the theoretical reasons for this discrepancy remain unknown. Read More

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December 2018

Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties.

Bioorg Chem 2018 Nov 24;84:326-338. Epub 2018 Nov 24.

Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland.

8-Hydroxyquinoline scaffold is a privileged structure used in designing a new active agents with therapeutic potential. Its connections with the sugar unit is formed to improve the pharmacokinetic properties. The broad spectrum of activity of quinoline derivatives, especially glycoconjugates, is often associated with the ability to chelate metal ions or with the ability to intercalate into DNA. Read More

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November 2018

Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis.

J Control Release 2018 Dec 7. Epub 2018 Dec 7.

Pathophysiological and Health Science Team, Imaging Platform and Innovation Group, Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan. Electronic address:

In vivo biodistribution analyses, especially in tumors, of nucleic acids delivered with nanoparticles are important to develop drug delivery technologies for medical use. We previously developed wrapsome® (WS), an ~100 nm liposomal nanoparticle that can encapsulate siRNA, and reported that WS accumulates in tumors in vivo and inhibits their growth by an enhanced permeability and retention effect. In the present study, we evaluated the pharmacokinetics of nucleic acid-containing nanoparticles by combining dynamic positron emission tomography (PET) imaging and liquid chromatography-tandem mass spectrometry (LC/MS/MS) analysis. Read More

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December 2018

Global optimization using Gaussian Processes to estimate biological parameters from image data.

J Theor Biol 2018 Dec 7. Epub 2018 Dec 7.

Department for Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland; Swiss Institute of Bioinformatics (SIB), Mattenstrasse 26, Basel, 4058, Switzerland. Electronic address:

Parameter estimation is a major challenge in computational modeling of biological processes. This is especially the case in image-based modeling where the inherently quantitative output of the model is measured against image data, which is typically noisy and non-quantitative. In addition, these models can have a high computational cost, limiting the number of feasible simulations, and therefore rendering most traditional parameter estimation methods unsuitable. Read More

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December 2018

Isolation and molecular characterization of Dengue virus clinical isolates from pediatric patients in New Delhi.

Int J Infect Dis 2018 Dec 7. Epub 2018 Dec 7.

Translational Health Science and Technology Institute, Faridabad, Haryana, INDIA. Electronic address:

Objectives: To characterize the in vitro replication fitness, viral diversity and phylogeny of dengue viruses (DENV) isolated from Indian patients.

Methods: DENV was isolated from whole blood collected from patients by passaging in cell culture. Passage 3 viruses were used for growth kinetics in C6/36 mosquito cells. Read More

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December 2018
2.330 Impact Factor

An integrated parametric model for MT self-assembly formation analysis.

Biosystems 2018 Dec 6. Epub 2018 Dec 6.

Department of Computer Science, Virginia Commonwealth University, Richmond, VA 23284, USA. Electronic address:

Self-assembly is a ubiquitous, naturally occurring, robust process in many living organisms. Microtubule (MT), a self-organization system assemble itself into functional units by attaching to cellular structures. Modeling microtubule self-organization is of interest as microtubule forms a network of protein filaments that is critical to many processes in eukaryotic cells. Read More

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December 2018
1 Read

m-CALP - Yet another way of generating handwritten data through evolution for pattern recognition.

Biosystems 2018 Dec 6. Epub 2018 Dec 6.

Department of Computer Science, FAST-NUCES, Faisal Town, Lahore. Electronic address:

Recently a cellular automata learning and prediction (CALP) model was proposed that used evolution to generate handwritten data for pattern recognition. However, the proposed method by CALP was mechanical and not intuitive, as it did not consider the degree of image deformation that takes place during evolution. The problem with this approach is that it evolved handwritten shapes to a completely different form. Read More

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December 2018

Nanoparticles in mitigating gaseous emissions from liquid dairy manure stored under anaerobic condition.

J Environ Sci (China) 2019 Feb 24;76:26-36. Epub 2018 Mar 24.

NanoScience Technology Center, University of Central Florida, Orlando, FL 32826, USA; Department of Chemistry, University of Central Florida, Orlando, FL 32826, USA.

A number of mitigation techniques exist to reduce the emissions of pollutant gases and greenhouse gases (GHGs) from anaerobic storage of livestock manure. Nanoparticle (NP) application is a promising mitigating treatment option for pollutant gases, but limited research is available on the mode of NP application and their effectiveness in gaseous emission reduction. In this study, zinc silica nanogel (ZnSNL), copper silica nanogel (CuSNL), and N-acetyl cysteine (NACL) coated zinc oxide quantum dot (Qdot) NPs were compared to a control lacking NPs. Read More

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February 2019
2.002 Impact Factor

Characterization and alkaline pretreatment of rice husk varieties in Uganda for potential utilization as precursors in the production of activated carbon and other value-added products.

Waste Manag 2018 Nov 6;81:104-116. Epub 2018 Oct 6.

Department of Chemical Engineering, KTH Royal Institute of Technology, SE 100 44 Stockholm, Sweden.

In this study, 13 rice husk (RH) varieties from 4 agro-ecological zones in Uganda were characterized, NaOH-pretreated, and evaluated for their potential utilization as precursors for production of bio-oil, ash, char, and activated carbon for selected applications. RH varieties were characterized through particle size analysis, bulk density, proximate and ultimate analyses, specific surface area, pore volume, as well as lignocellulosic and inorganic compositions. Selected RH varieties were subsequently pretreated at NaOH concentrations of 1-4%w/v, using pretreatment ratios of 5 g RH: 40 mL NaOH. Read More

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November 2018
1 Read

In vitro fermentation of O‑acetyl‑arabinoxylan from bamboo shavings by human colonic microbiota.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Institute of Agricultural Engineering, Fujian Academy of Agricultural Sciences, Fuzhou 350003, PR China.

BSH-1 is an O‑acetyl-arabinoxylan obtained from bamboo shavings. This study investigated its fermentation behavior by human colonic bacteria in vitro. Results showed that BSH-1 remarkably modulated the composition of colonic microbiota, mainly by increasing the growth of potential beneficial genera (i. Read More

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December 2018
8 Reads

Optimal control applied to a temperature dependent schistosomiasis model.

Biosystems 2018 Dec 3. Epub 2018 Dec 3.

School of Life Sciences, College of Agriculture, Engineering and Science, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.

Schistosomiasis, the most common water-borne infection worldwide, continues to pose a serious public health challenge in developing nations and to travellers who visit these endemic regions. We apply optimal control on a temperature dependent schistosomiasis model. Our optimal control aims to minimize the pre-patent and patent human population at minimal costs. Read More

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December 2018
4 Reads

Males with More Pheomelanin Have a Lower Oxidative Balance in Asian Barn Swallows (Hirundo rustica gutturalis).

Zoolog Sci 2018 Dec;35(6):505-513

2 Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan.

Pheomelanin-based plumage pigmentation has been suggested to be an honest signal of individual quality to conspecifics. It has been hypothesized that oxidative stress is an important agent linking pheomelanic pigmentation to individual quality. Using the Asian barn swallow Hirundo rustica gutturalis, a wild passerine, we tested whether the pheomelanin pigmentation in the red throat patch of adult males, a sexually selected trait, is associated with the ratio between reduced and oxidized glutathione (RGSH/GSSG) as an indicator of current oxidative balance during the early breeding season. Read More

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December 2018

Nervous system characterization during the development of a basal echinoderm, the feather star Antedon mediterranea.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Environmental Science and Policy, Università degli Studi di Milano, Milano, Italy.

Neural development of echinoderms has always been difficult to interpret, as larval neurons degenerate at metamorphosis and a tripartite nervous system differentiates in the adult. Despite their key phylogenetic position as basal echinoderms, crinoids have been scarcely studied in developmental research. However, since they are the only extant echinoderms retaining the ancestral body plan of the group, crinoids are extremely valuable models to clarify neural evolution in deuterostomes. Read More

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December 2018
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MER: a shell script and annotation server for minimal named entity recognition and linking.

J Cheminform 2018 Dec 5;10(1):58. Epub 2018 Dec 5.

LASIGE, Faculdade de Ciências, Universidade de Lisboa, 1749 016, Lisbon, Portugal.

Named-entity recognition aims at identifying the fragments of text that mention entities of interest, that afterwards could be linked to a knowledge base where those entities are described. This manuscript presents our minimal named-entity recognition and linking tool (MER), designed with flexibility, autonomy and efficiency in mind. To annotate a given text, MER only requires: (1) a lexicon (text file) with the list of terms representing the entities of interest; (2) optionally a tab-separated values file with a link for each term; (3) and a Unix shell. Read More

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December 2018
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A bi-end injection capillary electrophoresis method for simultaneous determination of 37 cations and anions in beers.

Anal Bioanal Chem 2018 Dec 6. Epub 2018 Dec 6.

Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

Capillary electrophoresis (CE) is excellent at separating all the ions in a sample but is rarely used as a result of its detection issue and easy loss of very fast ions by common one-end injection methods. Herein we propose a newly developed method aimed at simultaneous determination of positive and negative ions with a home-made CE device, featuring bi-end injection and contactless conductivity detection at the middle. By simply using 2. Read More

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December 2018
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The QIAGEN 140-locus single-nucleotide polymorphism (SNP) panel for forensic identification using massively parallel sequencing (MPS): an evaluation and a direct-to-PCR trial.

Int J Legal Med 2018 Dec 5. Epub 2018 Dec 5.

National Centre for Forensic Studies, Faculty of Science & Technology, University of Canberra, Canberra, ACT, Australia.

Massively parallel sequencing (MPS) of identity informative single-nucleotide polymorphisms (IISNPs) enables hundreds of forensically relevant markers to be analysed simultaneously. Generating DNA sequence data enables more detailed analysis including identification of sequence variations between individuals. The GeneRead DNAseq 140 IISNP MPS panel (QIAGEN) has been evaluated on both the MiSeq (Illumina) and Ion PGM™ (Applied Biosystems) MPS platforms using the GeneRead DNAseq Targeted Panels V2 library preparation workflow (QIAGEN). Read More

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December 2018