264 results match your criteria BioResearch open access[Journal]


Electroporation: A Sustainable and Cell Biology Preserving Cell Labeling Method for Adipogenous Mesenchymal Stem Cells.

Biores Open Access 2019 29;8(1):32-44. Epub 2019 Mar 29.

Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany.

Human mesenchymal stem cells derived from adipose tissue (AD-hMSCs) represent a promising source for tissue engineering and are already widely used in cell therapeutic clinical trials. Until today, an efficient and sustainable cell labeling system for cell tracking does not exist. We evaluated transient transfection through electroporation for cell labeling and compared it with lentiviral transduction for AD-hMSCs. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/biores.2019.0001
Publisher Site
http://dx.doi.org/10.1089/biores.2019.0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445215PMC
March 2019
2 Reads

After Gestational Diabetes: Impact of Pregnancy Interval on Recurrence and Type 2 Diabetes.

Biores Open Access 2019 25;8(1):59-64. Epub 2019 Mar 25.

Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts.

The contribution of pregnancy interval after gestational diabetes (GDM) to type 2 diabetes (T2DM) onset is a poorly understood but potentially modifiable factor for T2DM prevention. The purpose of this study was to assess the impact of GDM recurrence and/or delivery interval on follow-up care and T2DM onset in a sample of continuously insured women with a term livebirth within 3 years of a GDM-affected delivery. This is a secondary analysis of a cohort of 12,622 women with GDM, 2006-2012, drawn from a national administrative data system (OptumLabs Data Warehouse). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437620PMC

Patent Application Trends of Induced Pluripotent Stem Cell Technologies in the United States, Japanese, and European Applications.

Biores Open Access 2019 19;8(1):45-58. Epub 2019 Mar 19.

Department of Regenerative Medicine and Stem Cell Biology, School of Medicine, Fujita Health University, Toyoake, Japan.

Patent application trends were investigated for induced pluripotent stem cell (iPSC) technologies, particularly disease-specific cell technologies related to iPSCs, in the U.S., Japanese, and European applications during 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428227PMC
March 2019
1 Read

Combination of Treatments With or Without Surgery in Localized Provoked Vulvodynia: Outcomes After Three Years of Follow-Up.

Biores Open Access 2019 8;8(1):25-31. Epub 2019 Mar 8.

Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Most vulvodynia patients receive combinations of several treatment modalities for their chronic painful condition. If conservative treatments fail, vestibulectomy is considered to be the ultimate treatment option for localized provoked vulvodynia (LPV). The aim of this descriptive study was to analyze relief of pain, quality of life (QoL), and complications associated with combining surgery with conservative treatments among LPV patients, both in short term and after 3 years of follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415354PMC

Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia.

Biores Open Access 2019 1;8(1):16-24. Epub 2019 Mar 1.

Liggins Institute, University of Auckland, Auckland, New Zealand.

This study compared the effects of a high-calcium vitamin D fortified milk with added FOS-Inulin versus regular milk on serum parathyroid hormone (PTH), vitamin D status, grip strength (GS), as well as bone density in Chinese premenopausal women over 52 weeks. Premenopausal women ( = 133), mean age 41 (±5.1) years were randomized into control ( = 66; regular milk at 500 mg calcium per day) or intervention (Int;  = 67; fortified milk at 1200 mg calcium, 15 μg vitamin D, and 4 g FOS-Inulin per day) groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400229PMC
March 2019
1 Read

Vascular Tissue Engineering Using Scaffold-Free Prevascular Endothelial-Fibroblast Constructs.

Biores Open Access 2019 8;8(1):1-15. Epub 2019 Jan 8.

Department of Surgery, Medical University of South Carolina, Charleston, South Carolina.

Vascularization remains a substantial limitation to the viability of engineered tissue. By comparing vascularization dynamics of a self-assembled prevascular endothelial-fibroblast model to avascular grafts, we explore the vascularization rate limitations in implants at early time intervals, during which tissue hypoxia begins to affect cell viability. Scaffold-free prevascular endothelial-fibroblast constructs (SPECs) may serve as a modular and reshapable vascular bed in replacement tissues. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/biores.2018.0039
Publisher Site
http://dx.doi.org/10.1089/biores.2018.0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327854PMC
January 2019
1 Read

The Impact of Different High-Intensity Interval Training Protocols on Body Composition and Physical Fitness in Healthy Young Adult Females.

Biores Open Access 2018 28;7(1):177-185. Epub 2018 Dec 28.

School of Health Sciences, Oakland University, Rochester, Michigan.

Although traditional high-intensity interval training (HIIT) has been effective in improving body composition and physical fitness, it is unclear how multimodal HIIT affects these variables. This study compared the differences between these two training programs on body composition and physical fitness in apparently healthy, nonobese young adult females. A total of 16 participants (mean age = 23 ± 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323591PMC
December 2018

Activity Tracking Devices in Group Prenatal Care: A Feasibility Study.

Biores Open Access 2018 28;7(1):165-176. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.

To evaluate the feasibility (adherence to the study protocol and satisfaction) of using an activity tracking device (ATD) in group prenatal care. Women participated if they (1) were in group prenatal care, (2) owned a smartphone, and (3) had no activity restrictions. Women were instructed to wear and sync the ATD daily. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267286PMC
November 2018
2 Reads

Diagnosis and Management of an Adenomatoid Uterine Tumor: Ultrasound, Magnetic Resonance Imaging, Surgical Appearance, and Pathology Correlation.

Biores Open Access 2018 26;7(1):159-164. Epub 2018 Oct 26.

Department of Obstetrics and Gynecology and Texas Tech University Health Sciences Center, Lubbock, Texas.

Adenomatoid uterine tumors are rare, and their appearance on medical imaging modalities is not well established. We present a case of an adenomatoid uterine tumor reviewing a unique sonographic presentation, magnetic resonance imaging (MRI), gross surgical appearance of the tumor, and microscopic pathology images. A 29-year-old gravida 0 Caucasian woman presented with dysmenorrhea, menorrhagia, and desire to conceive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206546PMC
October 2018
5 Reads

Lean Body Mass in the Prediction of Bone Mineral Density in Postmenopausal Women.

Biores Open Access 2018 10;7(1):150-158. Epub 2018 Oct 10.

School of Food and Nutrition, Massey University, Palmerston North, New Zealand.

Owing to conflicting results of the association between body composition and bone mineral density (BMD), we investigated the relationship between fat mass (FM), lean mass (LM), and BMD in New Zealand postmenopausal women. We hypothesized that increased LM will indicate a higher BMD. A cross-sectional study was performed examining the associations between body composition, anthropometric measures, activity energy expenditure, and bone health status (using dual-energy X-ray absorptiometry [DXA]). Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/biores.2018.0025
Publisher Site
http://dx.doi.org/10.1089/biores.2018.0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188582PMC
October 2018
3 Reads

Efficacy of Adjunctive Hyperbaric Oxygen Therapy in Osteoradionecrosis.

Biores Open Access 2018 8;7(1):145-149. Epub 2018 Oct 8.

Hospital Hyperbaric Oxygen Therapy Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Osteoradionecrosis (ORN) is a common consequence resulting from radiation in patients with cancer. Presently, hyperbaric oxygen therapy (HBOT) is proposed to have a role in improving wound healing in ORN patients. There is no strong scientific evidence to confirm the benefits of HBOT for treatment of ORN as an adjunctive treatment. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/biores.2018.0019
Publisher Site
http://dx.doi.org/10.1089/biores.2018.0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178923PMC
October 2018
22 Reads

Breast Cancer Risk Among Women in Jail.

Biores Open Access 2018 20;7(1):139-144. Epub 2018 Sep 20.

Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, Kansas.

Over 200,000 women are diagnosed with breast cancer each year, and incarcerated women face unique risks associated with poor access to healthcare. Regular mammography can diagnose breast cancer early, giving the patient the best chance of survival. The objective of this study was to determine the proportion of jail incarcerated women who have received a mammogram and were up-to-date based on the most recent United States Preventive Services Task Force recommendations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151327PMC
September 2018
20 Reads

What's the Risk? Older Women Report Fewer Symptoms for Suspected Acute Coronary Syndrome than Younger Women.

Biores Open Access 2018 18;7(1):131-138. Epub 2018 Sep 18.

School of Nursing, University of North Carolina, Chapel Hill, North Carolina.

The purpose of the study was to determine whether older (≥65 years) and younger (<65 years) women presenting to the emergency department (ED) with symptoms suggestive of acute coronary syndrome (ACS) varied on risk factors, comorbid conditions, functional status, and symptoms that have implications for emergent cardiac care. Women admitted to five EDs were enrolled. The ACS Symptom Checklist was used to measure symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146306PMC
September 2018
22 Reads

Circulating Levels of Bone and Inflammatory Markers in Gestational Diabetes Mellitus.

Biores Open Access 2018 1;7(1):123-130. Epub 2018 Aug 1.

Division of Endocrinology Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York.

Gestational diabetes mellitus (GDM) can cause short- and long-term complications to the mother and fetus. While the precise mechanisms in preserving glucose balance in a healthy pregnancy are unknown, various growth factors and hormones have been implicated or associated with GDM risk in humans or rodents, including prolactin, tumor necrosis factor alpha (TNFα), osteoprotegerin (OPG), hepatocyte growth factor (HGF), and receptor activator of nuclear factor-kappa B ligand (RANKL). We aimed to evaluate the relationship of these and other protein markers in women with GDM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106713PMC
August 2018
1 Read

Impact of Central Obesity on Women with Polycystic Ovary Syndrome Undergoing Fertilization.

Biores Open Access 2018 1;7(1):116-122. Epub 2018 Aug 1.

Department of Gynecology and Obstetrics, Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Central obesity (CO) is a defining characteristic of polycystic ovary syndrome (PCOS) and PCOS-induced disorders are likely to be exacerbated in the presence of CO. This study aims to evaluate the impact of CO on infertile women with PCOS undergoing fertilization (IVF).It is a retrospective and case-control study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076435PMC
August 2018
3 Reads

A New Approach to Treating Neurodegenerative Otologic Disorders.

Biores Open Access 2018 1;7(1):107-115. Epub 2018 Jul 1.

ShangPharma Innovation, Inc., South San Francisco, California.

Hearing loss, the most common neurological disorder and the fourth leading cause of years lived with disability, can have profound effects on quality of life. The impact of this "invisible disability," with significant consequences, economic and personal, is most substantial in low- and middle-income countries, where >80% of affected people live. Given the importance of hearing for communication, enjoyment, and safety, with up to 500 million affected globally at a cost of nearly $800 billion/year, research on new approaches toward prevention and treatment is attracting increased attention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069589PMC
July 2018
2 Reads

Canine Placenta Recellularized Using Yolk Sac Cells with Vascular Endothelial Growth Factor.

Biores Open Access 2018 1;7(1):101-106. Epub 2018 Jul 1.

Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.

Regenerative medicine has been growing because of the emergent need for tissues/organs for transplants and restorative surgeries. Biological scaffolds are important tools to try to solve this problem. The one used in this reserach was developed by an acellular biological scaffold from canine placenta with a rich source of cellular matrix. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056259PMC
July 2018
20 Reads

Fatness and Fluctuating Body Weight: Effect on Central Vasculature.

Biores Open Access 2018 1;7(1):90-100. Epub 2018 Jun 1.

School of Nutrition and Health Promotion, Arizona State University, Phoenix, Arizona.

Weight Cycling (WC) is a prevalent behavior associated with adverse cardiovascular (CV) health. However, a 2010 review on the effects of WC and blood pressure (BP) determined that there was not enough evidence to draw definitive conclusions. Central BP is the principal predictor of CV risk compared to peripheral BP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994146PMC

LUBAC and ABIN-1 Modulate TRAIL-Based NF-κB Induction in Human Embryonic Kidney 293 Cells.

Biores Open Access 2018 1;7(1):81-89. Epub 2018 May 1.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to activate the canonical NF-κB pathway similar to TNF. The exact mechanism of the entire signaling cascade is still under investigation. The involvement of linear ubiquitylation as upregulating component has already been shown recently in some cell lines, but not in human embryonic kidney 293 (HEK293) cells. Read More

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/biores.2018.0006
Publisher Site
http://dx.doi.org/10.1089/biores.2018.0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982153PMC
May 2018
12 Reads

The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East.

Biores Open Access 2018 1;7(1):73-80. Epub 2018 May 1.

Department of Biochemistry & Cancer Biology, Meharry Medical College, Nashville, Tennessee.

Breast cancer is the most common malignancy among Arab women in Eastern Mediterranean Region (EMR). The incidence of breast cancer has substantially increased in recent years among this women population, especially those younger than 50, and the incidence is expected to double by 2030. Considerable experimental evidence supports the potential role of dietary habits and lifestyle in cancer etiology and cancer prevention. Read More

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/biores.2018.0004
Publisher Site
http://dx.doi.org/10.1089/biores.2018.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982158PMC
May 2018
5 Reads

Knowledge and Acceptance of Human Papillomavirus Vaccine for Cervical Cancer Prevention Among Urban Professional Women in Bangladesh: A Mixed Method Study.

Biores Open Access 2018 1;7(1):63-72. Epub 2018 May 1.

International Centre for Diarrheal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh.

Prophylactic human papillomavirus (HPV) vaccination is the most effective preventive method against invasive cervical cancer, the second leading cause of cancer-related deaths among women in Bangladesh. Evidence on women's knowledge and perception about cervical cancer and HPV vaccination are needed for effective implementation of national cervical cancer prevention programs. The objective of this study was to assess the knowledge, attitude, and acceptance of cervical cancer, HPV, and HPV vaccination among urban professional women in Bangladesh. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970545PMC
May 2018
2 Reads

Pilot Study of Dose-Response Effects of Exercise on Change in C-Reactive Protein, Cortisol, and Health-Related Quality of Life Among Cancer Survivors.

Biores Open Access 2018 1;7(1):52-62. Epub 2018 May 1.

Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, California.

Fatigue, stress, and depression contribute to poor health-related quality of life (HRQoL) among cancer survivors. This study examined the effects of combined aerobic and resistance training (CART) on HRQoL and biomarkers of stress. Cancer survivors ( = 76, 91% female, 39% breast cancer, 32% gynecologic cancer) were enrolled in CART for three 60-min sessions, weekly, for 26 weeks. Read More

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/biores.2018.0003
Publisher Site
http://dx.doi.org/10.1089/biores.2018.0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961455PMC
May 2018
3 Reads

Possible Association of Multicentric Castleman's Disease with Autoimmune Lymphoproliferative Syndrome.

Biores Open Access 2018 1;7(1):47-51. Epub 2018 Apr 1.

Department of Cardiology and Hematology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Multicentric Castleman's disease (MCD) is lymphoproliferative disorder characterized by systemic inflammatory symptoms such as fever and weight loss. Human herpes virus-8 (HHV-8) is thought to be a causable pathogen in all HIV-positive and some HIV-negative MCD patients. Furthermore, the term idiopathic MCD (iMCD) was recently proposed to represent a group of HIV-negative and HHV-8-negative patients with unknown etiologies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908426PMC
April 2018
3 Reads

Novel Biomarkers of Physical Activity Maintenance in Midlife Women: Preliminary Investigation.

Biores Open Access 2018 1;7(1):39-46. Epub 2018 Apr 1.

Structure and Function Unit, Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas.

The precision health initiative is leading the discovery of novel biomarkers as important indicators of biological processes or responses to behavior, such as physical activity. Neural biomarkers identified by magnetic resonance imaging (MRI) hold promise to inform future research, and ultimately, for transfer to the clinical setting to optimize health outcomes. This study investigated resting-state and functional brain biomarkers between midlife women who were maintaining physical activity in accordance with the current national guidelines and previously acquired age-matched sedentary controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908419PMC

Pseudotumor from Metal-on-Metal Total Hip Arthroplasty Causing Unilateral Leg Edema: Case Presentation and Literature Review.

Biores Open Access 2018 1;7(1):33-38. Epub 2018 Mar 1.

Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, Kansas.

Metal-on-metal (MoM) total hip arthroplasty (THA) can be associated with adverse metal reactions, including pseudotumors. This case report describes a 58-year-old female with an MoM THA-related pseudotumor that caused unilateral leg edema from compression of her external iliac vein. After thorough preoperative workup to rule out infection and deep vein thrombosis and consultation with a vascular surgeon, the patient underwent revision THA and excision of her pseudotumor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870059PMC
March 2018
5 Reads

Patient-Perceived Autonomy and Long-Acting Reversible Contraceptive Use: A Qualitative Assessment in a Midwestern, University Community.

Biores Open Access 2018 1;7(1):25-32. Epub 2018 Mar 1.

School of Public Health, University of Maryland College Park, College Park, Maryland.

Long-acting reversible contraceptives (LARCs) are the most effective contraceptives and are first-line recommendations for most women. However, young women use these methods at relatively low rates. Given concern with contraceptive coercion, an underexamined factor contributing to LARC attitudes is women's perceived reproductive and bodily autonomy in regard to LARC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868328PMC
March 2018
7 Reads

Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types.

Biores Open Access 2018 1;7(1):10-24. Epub 2018 Feb 1.

Faculty of Medicine and Health Sciences, Guy Hilton Research Center, Institute for Science and Technology in Medicine, Keele University, Staffordshire, United Kingdom.

The poor healing capacity of cartilage and lack of effective treatment for associated disease and trauma makes it a strong candidate for a regenerative medicine approach. Potential therapies tested to date, although effective, have met with a number of intrinsic difficulties possibly related to limited autologous chondrocyte cell yield and quality of cartilage produced. A potential mechanism to bypass limited cell yields and improve quality of differentiation is to immortalize relevant cell types through the ectopic expression of telomerase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2018.0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865620PMC
February 2018
3 Reads

Acid-Sensing Ion Channel 1a Regulates Fate of Rat Nucleus Pulposus Cells in Acid Stimulus Through Endoplasmic Reticulum Stress.

Biores Open Access 2018 1;7(1):2-9. Epub 2018 Feb 1.

Department of Spine Surgery, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China.

Acid-sensing ion channel 1a (ASIC1a) participates in human intervertebral disc degeneration (IVDD) and regulates the destiny of nucleus pulposus cells (NPCs) in acid stimulus. However, the mechanism of ASIC1a activation and its downstream pathway remain unclear. Endoplasmic reticulum (ER) stress also participates in the acid-induced apoptosis of NPCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808393PMC
February 2018
11 Reads

Epigenetic Treatment of Neurodegenerative Ophthalmic Disorders: An Eye Toward the Future.

Biores Open Access 2017 1;6(1):169-181. Epub 2017 Dec 1.

ShangPharma Innovation, Inc., South San Francisco, California.

Eye disease is one of the primary medical conditions that requires attention and therapeutic intervention in ageing populations worldwide. Further, the global burden of diabetes and obesity, along with heart disease, all lead to secondary manifestations of ophthalmic distress. Therefore, there is increased interest in developing innovative new approaches that target various mechanisms and sequelae driving conditions that result in adverse vision. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747116PMC
December 2017
3 Reads

PDK4 Deficiency Induces Intrinsic Apoptosis in Response to Starvation in Fibroblasts from Doberman Pinschers with Dilated Cardiomyopathy.

Biores Open Access 2017 1;6(1):182-191. Epub 2017 Dec 1.

Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida.

The Doberman pinscher (DP) canine breed displays a high incidence of idiopathic, nonischemic dilated cardiomyopathy (DCM) with increased mortality. A common mutation in DPs is a splice site deletion in the pyruvate dehydrogenase kinase 4 (PDK4) gene that shows a positive correlation with DCM development. PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability. Read More

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/biores.2017.0023
Publisher Site
http://dx.doi.org/10.1089/biores.2017.0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745584PMC
December 2017
5 Reads

Understanding Breast Cancer Knowledge and Barriers to Treatment Adherence: A Qualitative Study Among Breast Cancer Survivors.

Biores Open Access 2017 1;6(1):159-168. Epub 2017 Dec 1.

Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts.

Disparities in breast cancer treatment receipt are common and multifactorial. Data are limited on how knowledge about one's breast cancer and understanding treatment rationales may impact treatment completion. In this qualitative analysis, we explored barriers to care with a focus on knowledge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743034PMC
December 2017
2 Reads

An Autologous Anti-Inflammatory Protein Solution Yielded a Favorable Safety Profile and Significant Pain Relief in an Open-Label Pilot Study of Patients with Osteoarthritis.

Biores Open Access 2017 1;6(1):151-158. Epub 2017 Dec 1.

Zimmer Biomet, Warsaw, Indiana.

Osteoarthritis (OA) is a progressive and degenerative disease, which may result in significant pain and decreased quality of life. Recent updates in our understanding of OA have demonstrated that it is a whole joint disease that has many similarities to an unhealed wound containing inflammatory cytokines. The nSTRIDE Autologous Protein Solution (APS) Kit is a medical device under development for the treatment of OA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738995PMC
December 2017
3 Reads

Effects of Atrial Natriuretic Peptide on p53 and Estrogen Receptor in Breast Cancer Cells.

Biores Open Access 2017 1;6(1):141-150. Epub 2017 Oct 1.

Department of Biomedical Diagnostic Therapeutic Sciences, School of Health Sciences, Institute for Stem Cell Research and Center for Biomedical Research, Oakland University, Rochester, Michigan.

The atrial natriuretic peptide (ANP) hormone is secreted by cardiac atrial myocytes and acts to regulate blood pressure homeostasis in humans. Previous research indicates ANP treatment significantly decreases the proliferation of human prostate cancer cells, pancreatic adenocarcinoma, and breast cancer cells. Minimal studies have been conducted with regard to ANP regulating tumor suppressor genes and steroid hormone receptors in breast cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665415PMC
October 2017
15 Reads

Process Review for Development of Quantitative Risk Analyses for Transboundary Animal Disease to Pathogen-Free Territories.

Biores Open Access 2017 1;6(1):133-140. Epub 2017 Oct 1.

National Agricultural Biosecurity Center, Kansas State University, Manhattan, Kansas.

Outbreaks of transboundary animal diseases (TADs) have the potential to cause significant detriment to animal, human, and environmental health; severe economic implications; and national security. Challenges concerning data sharing, model development, decision support, and disease emergence science have recently been promoted. These challenges and recommendations have been recognized and advocated in the disciplines intersecting with outbreak prediction and forecast modeling regarding infectious diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2016.0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665416PMC
October 2017
1 Read

Gut Microbiota and Salivary Diagnostics: The Mouth Is Salivating to Tell Us Something.

Biores Open Access 2017 1;6(1):123-132. Epub 2017 Oct 1.

ShangPharma Innovation, Inc., South San Francisco, California.

The microbiome of the human body represents a symbiosis of microbial networks spanning multiple organ systems. Bacteria predominantly represent the diversity of human microbiota, but not to be forgotten are fungi, viruses, and protists. Mounting evidence points to the fact that the "microbial signature" is host-specific and relatively stable over time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665491PMC
October 2017
6 Reads

Human Chorionic Gonadotropin Mediated Generation of Reactive Oxygen Species Is Sufficient to Induce Meiotic Exit but Not Apoptosis in Rat Oocytes.

Biores Open Access 2017 1;6(1):110-122. Epub 2017 Sep 1.

Cell Physiology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Generation of reactive oxygen species (ROS) is associated with final stages of follicular development and ovulation in mammals. The human chorionic gonadotropin (hCG) mimics the action of luteinizing hormone and triggers follicular development and ovulation. However, it remains unclear whether hCG induces generation of ROS, if yes, whether hCG-mediated increased level of ROS could induce meiotic exit and/or apoptosis in rat oocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655844PMC
September 2017
3 Reads

Supporting the One-Carbon Cycle Restores Ovarian Reserve in Subfertile Women: Absence of Correlation with Urinary Bisphenol A Concentration.

Biores Open Access 2017 1;6(1):104-109. Epub 2017 Aug 1.

Laboratoire Clément, Paris, France.

Environmental endocrine disrupting chemicals (EDCs), including bisphenol A (BPA), induce DNA methylation errors and oxidative stress, and alter fertility. Animal studies have demonstrated that supporting the one-carbon cycle (1-CC) with appropriate dietary supplements can reduce the effects of EDCs. Anti-Mullerian hormone (AMH), a marker of ovarian functionality, has been tested in subfertile female patients, to control this hypothesis in humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628560PMC
August 2017
17 Reads

Local Cellular Responses to Titanium Dioxide from Orthopedic Implants.

Biores Open Access 2017 1;6(1):94-103. Epub 2017 Jul 1.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.

We evaluated recently published articles relevant to the biological effects of titanium dioxide (TiO) particles on local endogenous cells required for normal bone homeostasis, repair, and implant osseointegration. Structural characteristics, size, stability, and agglomeration of TiO particles alter the viability and behavior of multiple bone-related cell types. Resulting shifts in bone homeostasis may increase bone resorption and lead to clinical incidents of osteolysis, implant loosening, and joint pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627672PMC
July 2017
8 Reads

Prevalence and Risk Factors of Osteoporosis Among Jordanian Postmenopausal Women Attending the National Center for Diabetes, Endocrinology and Genetics in Jordan.

Biores Open Access 2017 1;6(1):85-93. Epub 2017 Jul 1.

Department of Endocrinology, The National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG)/The University of Jordan, Amman, Jordan.

To assess the prevalence of osteoporosis and osteopenia among Jordanian postmenopausal women attending the National Center for Diabetes, Endocrinology, and Genetics (NCDEG), and to determine the potential associated risk factors. A cross-sectional study was conducted at (NCDEG) in Amman, Jordan. A total of 1079 Jordanian postmenopausal women aged between 45 and 84 years were included in this study that was conducted during the period between April 2013 and December 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2016.0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515108PMC
July 2017
5 Reads

Decellularization of Human Internal Mammary Artery: Biomechanical Properties and Histopathological Evaluation.

Biores Open Access 2017 1;6(1):74-84. Epub 2017 Jun 1.

Section of Tissue Engineering and Stem Cell Therapy, Pediatric Urology and Regenerative Medicine Research Center, Children's Hospital Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.

This study undertook to create small-diameter vascular grafts and assess their structure and mechanical properties to withstand arterial implantation. Twenty samples of intact human internal mammary arteries (IMAs) were collected and decellularized using detergent-based methods. To evaluate residual cellular and extracellular matrix (ECM) components, histological analysis was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2016.0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515095PMC
June 2017
23 Reads

Induced Pluripotent Stem Cells: Global Research Trends.

Biores Open Access 2017 1;6(1):63-73. Epub 2017 Jun 1.

Platform of Therapeutics for Rare Disease, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.

The induced pluripotent stem cell (iPSC) was first described more than 10 years ago and is currently used in various basic science and clinical research fields. The aim of this report is to examine the trends in research using iPSCs over the last 10 years. The 2006-2016 PubMed database was searched using the MeSH term "induced pluripotent stem cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515092PMC
June 2017
5 Reads

The Top 50 Most Cited Articles in Cartilage Regeneration.

Biores Open Access 2017 1;6(1):58-62. Epub 2017 Jun 1.

Department of Trauma and Orthopaedics, Galway University Hospital, Galway, Ireland.

The aim of this study was to identify and analyze the top 50 most cited articles in cartilage regeneration. The impact of a scientific journal can be gauged by the total number of citations it has accrued. The top 50 most cited articles involving cartilage regeneration represent the most quoted level of evidence among this new subspecialty. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515090PMC
June 2017
2 Reads

Tissue-Engineered Tendon for Enthesis Regeneration in a Rat Rotator Cuff Model.

Biores Open Access 2017 1;6(1):47-57. Epub 2017 Jun 1.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Healing of rotator cuff (RC) injuries with current suture or augmented scaffold techniques fails to regenerate the enthesis and instead forms a weaker fibrovascular scar that is prone to subsequent failure. Regeneration of the enthesis is the key to improving clinical outcomes for RC injuries. We hypothesized that the utilization of our tissue-engineered tendon to repair either an acute or a chronic full-thickness supraspinatus tear would regenerate a functional enthesis and return the biomechanics of the tendon back to that found in native tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2016.0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515124PMC
June 2017
17 Reads

Biores Open Access 2016;5:137-145.

Authors:

Biores Open Access 2017 1;6(1):46. Epub 2017 May 1.

[This corrects the article DOI: 10.1089/biores.2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2016.0010.correxDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443137PMC

Characterization of a Murine Model of Bioequivalent Bladder Wound Healing and Repair Following Subtotal Cystectomy.

Biores Open Access 2017 1;6(1):35-45. Epub 2017 May 1.

Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina.

Previous work demonstrated restoration of a bioequivalent bladder within 8 weeks of removing the majority of the bladder (subtotal cystectomy or STC) in rats. The goal of the present study was to extend our investigations of bladder repair to the murine model, to harness the power of mouse genetics to delineate the cellular and molecular mechanisms responsible for the observed robust bladder regrowth. Female C57 black mice underwent STC, and at 4, 8, and 12 weeks post-STC, bladder repair and function were assessed via cystometry, pharmacologic organ bath studies, and -weighted magnetic resonance imaging (MRI). Read More

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/biores.2017.0011
Publisher Site
http://dx.doi.org/10.1089/biores.2017.0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439456PMC
May 2017
19 Reads

Cataract Surgery and Visual Acuity in Elderly Japanese: Results of Fujiwara-kyo Eye Study.

Biores Open Access 2017 1;6(1):28-34. Epub 2017 Apr 1.

Department of Ophthalmology, Nara Medical University, Kashihara, Japan.

The aim of this study was to determine the presence of prior cataract surgery and best-corrected visual acuity (BCVA) in an elderly Japanese cohort. The Fujiwara-kyo Eye Study was a prospective, population-based, cross-sectional epidemiological study. The subjects were ≥68 years who lived in the Nara Prefecture and responded to recruitment notices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397236PMC
April 2017
4 Reads

Can Handgrip Strength Improve Following Body Mass-Based Lower Body Exercise?

Biores Open Access 2017 1;6(1):19-27. Epub 2017 Mar 1.

Department of Sports and Life Sciences, National Institute of Fitness and Sports in Kanoya, Kagoshima, Japan.

Knee extension strength (KES) improves following body mass-based lower body exercise training; however, it is unknown whether this type of exercise increases handgrip strength (HGS) as a result of a cross-education effect in older individuals. Our aim was to investigate the effect of a body mass-based exercise intervention on HGS and KES in older adults. At baseline, 166 subjects started a 12-week intervention program, and 160 (108 women and 52 men) subjects completed the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385419PMC
March 2017
2 Reads

Real-Time Three-Dimensional Echocardiography: Characterization of Cardiac Anatomy and Function-Current Clinical Applications and Literature Review Update.

Biores Open Access 2017 1;6(1):15-18. Epub 2017 Mar 1.

Banner University Medical Center , Sarver Heart Center, Tucson, Arizona.

Our review of real-time three-dimensional echocardiography (RT3DE) discusses the diagnostic utility of RT3DE and provides a comparison with two-dimensional echocardiography (2DE) in clinical cardiology. A Pubmed literature search on RT3DE was performed using the following key words: transthoracic, two-dimensional, three-dimensional, real-time, and left ventricular (LV) function. Articles included perspective clinical studies and meta-analyses in the English language, and focused on the role of RT3DE in human subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2016.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349224PMC
March 2017
4 Reads

Gender Differences in Post-Traumatic Stress.

Biores Open Access 2017 1;6(1):7-14. Epub 2017 Feb 1.

Dipartimento Emergenza-Urgenza, UNIMORE , Modena, Italy .

Acute stress can trigger cardiovascular events and disease. The earthquake is an "ideal" natural experiment for acute and chronic stress, with impact mainly on the cardiovascular system. On May 20th and 29th, 2012, two earthquakes of magnitude 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2017.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327031PMC
February 2017
26 Reads

Biomimetics of Bone Implants: The Regenerative Road.

Biores Open Access 2017 1;6(1):1-6. Epub 2017 Jan 1.

Hagey Laboratory for Pediatric Regenerative Medicine, Plastic and Reconstructive Surgery Division, Department of Surgery, Stanford University School of Medicine , Stanford, California.

The current strategies for healing bone defects are numerous and varied. At the core of each bone healing therapy is a biomimetic mechanism, which works to enhance bone growth. These range from porous scaffolds, bone mineral usage, collagen, and glycosaminoglycan substitutes to transplanted cell populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/biores.2016.0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248549PMC
January 2017
4 Reads