297 results match your criteria BioResearch open access[Journal]


Movement Analysis with Inertial Measurement Unit Sensor After Surgical Treatment for Distal Radius Fractures.

Biores Open Access 2020 21;9(1):151-161. Epub 2020 May 21.

Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University, Rome, Italy.

Inertial measurement unit (IMU) has recently been used to evaluate a movement of a body segment to provide accurate information of movement's characteristics. IMU systems have been validated to successfully measure joint angle during upper limb range of motion (ROM). The study aimed to retrospectively evaluate, using an IMU, the ROM recovery of the wrist after surgical treatment for distal-radius fractures with Kirschner wire fixation (KWF) or with volar plate fixation (VPF) and screws. Read More

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http://dx.doi.org/10.1089/biores.2019.0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247043PMC

Crimean-Congo Hemorrhagic Fever Virus: Advances in Vaccine Development.

Biores Open Access 2020 12;9(1):137-150. Epub 2020 May 12.

Division of Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

Crimean-Congo hemorrhagic fever (CCHF) is a severe human disease with mortality rates of up to 30%. The disease is widespread in Africa, Asia, the Middle East and Eastern Europe. The last few years have seen disease emergence in Spain for the first time and disease re-emergence in other regions of the world after periods of inactivity. Read More

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http://dx.doi.org/10.1089/biores.2019.0057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247048PMC

Induced Pluripotent Stem Cells: Reprogramming Platforms and Applications in Cell Replacement Therapy.

Biores Open Access 2020 28;9(1):121-136. Epub 2020 Apr 28.

Medical Genetics Laboratory, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

The generation of induced pluripotent stem cells (iPSCs) from differentiated mature cells is one of the most promising technologies in the field of regenerative medicine. The ability to generate patient-specific iPSCs offers an invaluable reservoir of pluripotent cells, which could be genetically engineered and differentiated into target cells to treat various genetic and degenerative diseases once transplanted, hence counteracting the risk of graft versus host disease. In this context, we review the scientific research streams that lead to the emergence of iPSCs, the roles of reprogramming factors in reprogramming to pluripotency, and the reprogramming strategies. Read More

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http://dx.doi.org/10.1089/biores.2019.0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194323PMC

Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells.

Biores Open Access 2020 27;9(1):116-120. Epub 2020 Apr 27.

Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.

Goshajinkigan (GJG) is a traditional Japanese Kampo medicine used clinically to treat muscle pain in Japan. However, its underlying mechanism remains unclear. Since voltage-gated sodium channel (Nav) 1. Read More

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http://dx.doi.org/10.1089/biores.2019.0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194311PMC

Importance of Osmolarity and Oxygen Tension for Cartilage Tissue Engineering.

Biores Open Access 2020 31;9(1):106-115. Epub 2020 Mar 31.

Osteoarthritis Research, Merck KGaA, Darmstadt, Germany.

For cartilage repair or evaluation of new therapeutic approaches , the generation of functional cartilage tissue is of crucial importance and can only be achieved if the phenotype of the chondrocytes is preserved. Three-dimensional (3D) cell culture is broadly used for this purpose. However, adapting culture parameters like the oxygen tension or the osmolarity to their physiological values is often omitted. Read More

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http://dx.doi.org/10.1089/biores.2020.0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133430PMC

Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs.

Biores Open Access 2020 31;9(1):94-105. Epub 2020 Mar 31.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.

In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by acting on mitochondrial function, thereby heralding a life-saving path forward for patients suffering from neuroinflammatory diseases. Disorders of myelin in the nervous system damage the transmission of signals, resulting in loss of vision, motion, sensation, and other functions depending on the affected nerves, currently with no effective treatment. Read More

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http://dx.doi.org/10.1089/biores.2020.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133426PMC

Cloning and Protein Expression of Gene in ESX-5 System from .

Biores Open Access 2020 31;9(1):86-93. Epub 2020 Mar 31.

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan.

() is the causative agent of tuberculosis in human. One of the major virulence factors is early secretory antigenic target of 6-kDa (ESAT-6), and EccB protein encoded by is one of its components. EccB protein is a transmembrane protein in ESX-5 system. Read More

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http://dx.doi.org/10.1089/biores.2019.0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133456PMC

Influence of Menopausal Hormone Therapy on Body Composition and Metabolic Parameters.

Biores Open Access 2020 17;9(1):80-85. Epub 2020 Mar 17.

Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.

The loss of estrogen with menopause is associated with an increase in central fat. The objective of this study was to evaluate the effects of menopause hormone therapy (HT) on body composition and metabolic parameters in postmenopausal women. A prospective study was conducted among postmenopausal women from the Climacteric clinic, Universidade Federal de São Paulo. Read More

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http://dx.doi.org/10.1089/biores.2019.0050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097676PMC

Comparison of Somatic Mutation Profiles Between Formalin-Fixed Paraffin Embedded Tissues and Plasma Cell-Free DNA from Ovarian Cancer Patients Before and After Surgery.

Biores Open Access 2020 13;9(1):73-79. Epub 2020 Mar 13.

Clinic of Gynecology and Obstetrics, Martin University Hospital (MUH) and JFM CU, Martin, Slovakia.

Ovarian carcinogenesis can be induced by a large number of somatic gene mutations. Circulating tumor DNA (ctDNA) released into peripheral blood can provide insights into the genomic landscape of cancer cells and monitor their dynamics. Our aim was to detect and compare the genetic profiles in tumor tissue and plasma before and after tumor resection in ovarian cancer patients. Read More

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http://dx.doi.org/10.1089/biores.2019.0031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097678PMC

Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy.

Biores Open Access 2020 12;9(1):64-72. Epub 2020 Mar 12.

Department of Pharmacology, Animal Physiology and Physiology Chemistry, Trakia University, Stara Zagora, Bulgaria.

Many studies have shown that mitochondrial metabolism has a fundamental role in induction of carcinogenesis due to the influence of increased levels of reactive oxygen species (ROS) generation in all steps of oncogene transformation and cancer progression. It is widely accepted that the anticancer effect of conventional anticancer drugs is due to induction of oxidative stress and elevated intracellular levels of ROS, which alter the redox homeostasis of cancer cells. On the other hand, the harmful side effects of conventional anticancer chemotherapeutics are also due to increased production of ROS and disruption of redox homeostasis of normal cells and tissues. Read More

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http://dx.doi.org/10.1089/biores.2019.0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097683PMC

Glial Fibrillary Acidic Protein as Biomarker Indicates Purity and Property of Auricular Chondrocytes.

Biores Open Access 2020 3;9(1):51-63. Epub 2020 Mar 3.

Department of Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Instead of the silicone implants previously used for repair and reconstruction of the auricle and nose lost due to accidents and disease, a new treatment method using tissue-engineered cartilage has been attracting attention. The quality of cultured cells is important in this method because it affects treatment outcomes. However, a marker of chondrocytes, particularly auricular chondrocytes, has not yet been established. Read More

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http://dx.doi.org/10.1089/biores.2019.0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057647PMC

Multiomics Evaluation of Human Fat-Derived Mesenchymal Stem Cells on an Osteobiologic Nanocomposite.

Biores Open Access 2020 21;9(1):37-50. Epub 2020 Feb 21.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee.

Effective graft technologies for bone repair have been a primary focus in the field of bone tissue engineering. We have previously fabricated and examined a nanocomposite composed of polyurethane, nano-hydroxyapatite, and decellularized bone particles, which demonstrated osteobiologic characteristics. To evaluate the underlying mechanisms of this biomaterial, human adipose-derived mesenchymal stem cell seeded scaffolds were assessed using a combinatorial approach of transcriptomic and metabolomic analyses. Read More

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http://dx.doi.org/10.1089/biores.2020.0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047255PMC
February 2020

Regeneration of Decellularized Pig Esophagus Using Human Amniotic Stem Cells.

Biores Open Access 2020 21;9(1):22-36. Epub 2020 Feb 21.

Laboratory for Transplantation and Regenerative Medicine, Sahlgrenska Academy at Gothenburg University and the Sahlgrenska Transplant Institute at Sahlgrenska University Hospital, Gothenburg, Sweden.

Decellularization of esophagus was studied using three different protocols. The sodium deoxycholate/DNase-I (SDC/DNase-I) method was the most successful as evidenced by histology and DNA quantification of the acellular scaffolds. Acellular scaffolds were further analyzed and compared with native tissue by histology, quantitative analysis of DNA, and extracellular matrix (ECM) proteins. Read More

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http://dx.doi.org/10.1089/biores.2019.0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047253PMC
February 2020

Expression of Estrogen-Related Receptors in Localized Provoked Vulvodynia.

Biores Open Access 2020 21;9(1):13-21. Epub 2020 Feb 21.

Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland.

Eight percent of women suffer from vulvodynia, a chronic pain condition with unknown etiology. Inflammation and dysregulation of estrogen signaling have been suggested to play a role in the pathogenesis of localized provoked vulvodynia (LPV). Therefore, the aim of the study was to analyze protein expression levels of estrogen-related receptors ERRα, ERRß, ERRγ, estrogen receptor (ERα), and progesterone receptor (PRα) and CD3-positive T cells in the vulvar vestibulum obtained from women suffering from LPV in comparison to healthy, unaffected controls. Read More

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http://dx.doi.org/10.1089/biores.2019.0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047250PMC
February 2020

Increased Urinary Concentration of C-Terminal Telopeptide of Type II Collagen and Pain by Radiographic Grade in Women with Knee Osteoarthritis in Northeastern Mexico: A Cross-Sectional Study.

Biores Open Access 2020 12;9(1):7-12. Epub 2020 Feb 12.

Unidad Médica de Alta Especialidad No. 71, División de Investigación en Salud, Departamento de Trasplantes, Instituto Mexicano del Seguro Social, Torreón, México.

Osteoarthritis (OA) of the knee causes disability, pain, and progressive destruction of cartilage in adult women. The objective of the study was to evaluate the concentrations of the urinary biomarker C-terminal telopeptide of type II collagen (CTX-II) and pain by radiographic grade in women with knee OA in northeastern Mexico: Cross-sectional study of 155 women with knee OA. Concentrations of biochemical parameters were evaluated and urine samples were collected to measure biomarker levels (uCTX-II) ng/mmol by competitive enzyme-linked immunoabsorbent assay (ELISA) technique and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale was used for pain classification; median age of 49 years and 29. Read More

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http://dx.doi.org/10.1089/biores.2019.0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019197PMC
February 2020

Serum Lipidomic Profiling in Breast Cancer to Identify Screening, Diagnostic, and Prognostic Biomarkers.

Biores Open Access 2020 3;9(1):1-6. Epub 2020 Jan 3.

National Laboratory of Reference, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.

Breast cancer is the major mortality cause of women worldwide. In the course of management of breast cancer, the identification of a biomarker is important in enhancing our knowledge on cancer pathology, predicting the response to treatment, and selecting the patients who are more favorable to receive certain treatments. These biomarkers have a prognostic value. Read More

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http://dx.doi.org/10.1089/biores.2018.0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945794PMC
January 2020

A Novel Rehabilitative Protocol in the Treatment of Mixed Urinary Incontinence in Women: The Effects of Focused Mechano-Acoustic Vibration.

Biores Open Access 2019 20;8(1):219-228. Epub 2019 Dec 20.

Unit of Physical Medicine and Rehabilitation, Department of Medical and Oral Sciences and Biotechnologies (DSMOB), G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.

Dysfunctions of the pelvic floor related to mixed urinary incontinence in women are pathologies extremely limiting for patients bodily and psychosocial conditions, altering their quality of life. The aim of this study was to determine the effects of focal mechanical vibrations in mixed urinary incontinence. In this retrospective observational case-control study, 65 patients were randomized and divided into 2 groups: treatment group by focal mechanical vibrations (VISS-10 sessions) ( = 33) and a control group in waiting list ( = 32). Read More

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http://dx.doi.org/10.1089/biores.2019.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931011PMC
December 2019

Enhancement of Cellular Adhesion and Proliferation in Human Mesenchymal Stromal Cells by the Direct Addition of Recombinant Collagen I Peptide to the Culture Medium.

Biores Open Access 2019 22;8(1):210-218. Epub 2019 Nov 22.

Department of Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.

Mesenchymal stromal cells (MSCs) have considerable potential for a wide range of clinical applications and regenerative medicine and cell therapy. As a consequence, there is considerable interest in developing robust culture methods for producing large number of MSCs for use in repair of injured tissues or treatment of diseases. In general, tissue culture plates or flasks that have been precoated with substrates derived from animal tissues are used in the production of MSCs. Read More

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http://dx.doi.org/10.1089/biores.2019.0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873350PMC
November 2019

Prediction of Drug Permeability Using Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.

Biores Open Access 2019 14;8(1):200-209. Epub 2019 Nov 14.

FUJIFILM Cellular Dynamics, Inc., Madison, Wisconsin.

The strong barrier function of the blood-brain barrier (BBB) protects the central nervous system (CNS) from xenobiotic substances, while the expression of selective transporters controls the transportation of nutrients between the blood and brain. As a result, the delivery of drugs to the CNS and prediction of the ability of specific drugs to penetrate the BBB can be difficult. Although pharmacokinetic analysis using rodents is a commonly used method for predicting human BBB permeability, novel BBB models, such as Transwell models, have been developed recently. Read More

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http://dx.doi.org/10.1089/biores.2019.0026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854432PMC
November 2019

Effects of Human Adipose Tissue-Derived and Umbilical Cord Tissue-Derived Mesenchymal Stem Cells in a Dextran Sulfate Sodium-Induced Mouse Model.

Biores Open Access 2019 11;8(1):185-199. Epub 2019 Nov 11.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Mesenchymal stem cells (MSCs) can be acquired from medical waste. MSCs are easily expanded and have multiple functions, including anti-inflammatory effects. We evaluated the effects of human adipose tissue-derived MSCs (AD-MSCs) and umbilical cord tissue-derived MSCs (UC-MSCs) in a dextran sulfate sodium (DSS)-induced mouse model. Read More

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http://dx.doi.org/10.1089/biores.2019.0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844129PMC
November 2019

Hormone-Like Effects of Bisphenol A on p53 and Estrogen Receptor Alpha in Breast Cancer Cells.

Biores Open Access 2019 31;8(1):169-184. Epub 2019 Oct 31.

Department of Biomedical Diagnostic and Therapeutic Sciences, School of Health Sciences, Center of Biomedical Research, Oakland University, Rochester, Michigan.

Bisphenol A (BPA) is a polymerizing agent commonly found in plastics that has been linked to xenoestrogenic activity. In this study, we analyzed the estrogen-like effects of BPA on the expression of estrogen receptor (ER)α and p53 with hormonal and antihormonal treatments in T-47D and MCF-7 cells. Cells were cultured in medium containing 5% charcoal-stripped fetal bovine serum for 6 days to deplete any endogenous steroids or effectors. Read More

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http://dx.doi.org/10.1089/biores.2018.0048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823605PMC
October 2019

The Cytotoxic Effects of Geranylgeranylacetone Are Attenuated in the High-Glucose Condition.

Biores Open Access 2019 25;8(1):162-168. Epub 2019 Oct 25.

Department of Cellular and Integrative Physiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.

Geranylgeranylacetone (GGA) has been used as an antiulcer drug and also is known as inducer of heat shock protein 70 that has cytoprotective effects especially in hyperglycemic condition. In contrast, cytotoxicity of GGA has also been reported. Some studies have reported that GGA suppresses cell growth and induces apoptosis in cell models of human leukemia, ovarian carcinoma, and colon cancer . Read More

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http://dx.doi.org/10.1089/biores.2018.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814082PMC
October 2019

Improving Uptake and Adherence to 17-Hydroxyprogesterone Caproate in Non-Hispanic Black Women: A Mixed Methods Study of Potential Interventions from the Patient Perspective.

Biores Open Access 2019 23;8(1):155-161. Epub 2019 Oct 23.

Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina.

Women with a history of a preterm birth (PTB) are at high risk for recurrence. Weekly 17-hydroxyprogestrone caproate (17-P) injections can reduce the risk of recurrence in women with prior spontaneous PTB. PTB occurs disproportionately in non-Hispanic black (NHB) women, and uptake and adherence to 17-P among NHB women are lower compared to women in other racial/ethnic groups. Read More

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http://dx.doi.org/10.1089/biores.2019.0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806361PMC
October 2019

The Relationship Between Alcohol and Glycohemoglobin: A Biopsychosocial Perspective.

Authors:
David A Wiss

Biores Open Access 2019 3;8(1):146-154. Epub 2019 Oct 3.

Department of Community Health Sciences, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.

With the rising prevalence of type 2 diabetes mellitus (T2DM), there is debate regarding biological and psychosocial risk factors. While it is well established that alcohol lowers glycohemoglobin (HbA1c) levels, it is less clear whether alcohol consumption is protective of T2DM. It is also unclear how gender and ethnicity influence the utility of HbA1c screening as a tool for T2DM diagnosis, particularly in the context of alcohol use. Read More

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http://dx.doi.org/10.1089/biores.2019.0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776959PMC
October 2019

Knowledge of Cervical Cancer and Acceptability of Prevention Strategies Among Human Papillomavirus-Vaccinated and Human Papillomavirus-Unvaccinated Adolescent Women in Eldoret, Kenya.

Biores Open Access 2019 20;8(1):139-145. Epub 2019 Aug 20.

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

Cervical cancer is a critical public health concern in sub-Saharan Africa. Adolescents are key targets in primary prevention strategies. Following a human papillomavirus (HPV) vaccination initiative () in Eldoret, Kenya, the knowledge and source of information of cervical cancer and acceptance of prevention strategies among vaccinated and unvaccinated adolescents were evaluated. Read More

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http://dx.doi.org/10.1089/biores.2019.0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715544PMC

Regulation of Myogenic Activity by Substrate and Electrical Stimulation .

Biores Open Access 2019 30;8(1):129-138. Epub 2019 Jul 30.

Department of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, Saint Louis University, St. Louis, Missouri.

Skeletal muscle has a remarkable regenerative capacity in response to mild injury. However, when muscle is severely injured, muscle regeneration is impaired due to the loss of muscle-resident stem cells, known as satellite cells. Fibrotic tissue, primarily comprising collagen I (COL), is deposited with this critical loss of muscle. Read More

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http://dx.doi.org/10.1089/biores.2019.0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664826PMC

Changes in Spine Alignment and Postural Balance After Breast Cancer Surgery: A Rehabilitative Point of View.

Biores Open Access 2019 30;8(1):121-128. Epub 2019 Jul 30.

Umberto I University Hospital, Rome, Italy.

Breast cancer is the most common malignant tumor in female patients in developed countries. Recent articles indicate that one-sided mastectomy or minor breast surgery to treat breast cancer can have deleterious effects on posture and the musculoskeletal system. The purpose of this study was to investigate the alterations post-breast cancer surgery of the spine alignment associated to the balance not reported by the noninvasive instrumentation. Read More

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http://dx.doi.org/10.1089/biores.2018.0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664823PMC
July 2019
4 Reads

Hyper-Crosslinked Carbohydrate Polymer for Repair of Critical-Sized Bone Defects.

Biores Open Access 2019 1;8(1):111-120. Epub 2019 Jul 1.

Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California.

This study evaluated the safety and efficacy of a novel hyper-crosslinked carbohydrate polymer (HCCP) for the repair of critical-sized bone defects in comparison to two alternative treatments: autologous bone and poly(lactide-co-glycolide) with hyaluronic acid (PLGA/HA). Bilateral critical-sized defects were created in the lateral femoral condyles of skeletally mature New Zealand White rabbits, and they were subsequently implanted with HCCP, PLGA/HA, or autologous bone in a randomized manner. Clinical and behavioral observations were made daily, and radiological and histopathological evaluations were performed at 4, 10, and 16 weeks postimplantation. Read More

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http://dx.doi.org/10.1089/biores.2019.0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657362PMC

Therapeutic Alliance in a Single Versus Group Rehabilitative Setting After Breast Cancer Surgery: Psychological Profile and Performance Rehabilitation.

Biores Open Access 2019 3;8(1):101-110. Epub 2019 Jul 3.

Department of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy.

The survival rate of women after breast cancer has improved significantly worldwide. More attention should be paid to the rehabilitation intervention after surgery. Cancer rehabilitation helps breast cancer survivors maintain the highest possible physical, social, psychological, and vocational function in the limits that are imposed by the cancer and its treatments. Read More

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http://dx.doi.org/10.1089/biores.2019.0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607049PMC
July 2019
6 Reads

Will Women Interact with Technology to Understand Their Cardiovascular Risk and Potentially Increase Activity?

Biores Open Access 2019 3;8(1):94-100. Epub 2019 Jul 3.

Mount Royal University, Calgary, Canada.

Cardiovascular disease (CVD) continues to be one of the leading causes of death for women. New approaches need to be identified that will enable women to recognize modifiable risk factors and target their efforts toward prevention. The objectives of this study were to (1) determine if women would access Vivametrica to assess CVD risk, (2) identify whether women would increase their physical activity as measured by their daily step counts, and (3) elicit women's opinions about using the system, prospective observational study design. Read More

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http://dx.doi.org/10.1089/biores.2018.0047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607047PMC

How Health Care Providers Can Use Digital Health Technologies to Inform Human Papillomavirus (HPV) Decision Making and Promote the HPV Vaccine Uptake Among Adolescents and Young Adults.

Biores Open Access 2019 10;8(1):84-93. Epub 2019 Jun 10.

Department of Human Development and Organization Studies in Education, College of Education, University of Florida, Gainesville, Florida.

High-risk stains of human papillomavirus (HPV) is linked to causing cancer, is highly prevalent, and has increased incidence among adolescents and young adults. However, vaccination rates are low. Health care provider recommendation is the biggest influencer toward vaccine uptake. Read More

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https://www.liebertpub.com/doi/10.1089/biores.2018.0051
Publisher Site
http://dx.doi.org/10.1089/biores.2018.0051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581018PMC
June 2019
37 Reads

The Effect of Calcium and Glucose Concentration on Corneal Epithelial Cell Lines Differentiation, Proliferation, and Focal Adhesion Expression.

Biores Open Access 2019 5;8(1):74-83. Epub 2019 Jun 5.

Trinity Centre for Biomedical Engineering, Trinity Biomedical Science Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland.

It is known that culture media composition can affect cell behavior, morphology, and gene expression. However, in the case of corneal epithelial cells, the combined role of calcium and glucose concentration in media has not previously been examined. In this study, a human immortalized corneal epithelial cell line was used to examine the effect of glucose and calcium concentrations on these cells. Read More

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http://dx.doi.org/10.1089/biores.2018.0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555176PMC
June 2019
1 Read

Acceptability of Human Papillomavirus Self-Sampling Among a National Sample of Women in the United States.

Biores Open Access 2019 30;8(1):65-73. Epub 2019 Apr 30.

Division of Health Behavior and Health Promotion, College of Public Health, The Ohio State University, Columbus, Ohio.

As human papillomavirus (HPV) self-sampling continues to emerge as a potential cervical cancer screening strategy in the United States, it is necessary to examine women's acceptability of this screening approach. Furthermore, since several HPV self-sampling devices exist, it is important to determine if women's preferences differ by device type. We conducted an online survey in Fall 2017 with a national sample of women ( = 605) ages 21-65 years (the recommended age range for cervical cancer screening). Read More

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https://www.liebertpub.com/doi/10.1089/biores.2018.0040
Publisher Site
http://dx.doi.org/10.1089/biores.2018.0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497327PMC
April 2019
6 Reads

Electroporation: A Sustainable and Cell Biology Preserving Cell Labeling Method for Adipogenous Mesenchymal Stem Cells.

Biores Open Access 2019 29;8(1):32-44. Epub 2019 Mar 29.

Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany.

Human mesenchymal stem cells derived from adipose tissue (AD-hMSCs) represent a promising source for tissue engineering and are already widely used in cell therapeutic clinical trials. Until today, an efficient and sustainable cell labeling system for cell tracking does not exist. We evaluated transient transfection through electroporation for cell labeling and compared it with lentiviral transduction for AD-hMSCs. Read More

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https://www.liebertpub.com/doi/10.1089/biores.2019.0001
Publisher Site
http://dx.doi.org/10.1089/biores.2019.0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445215PMC
March 2019
12 Reads

After Gestational Diabetes: Impact of Pregnancy Interval on Recurrence and Type 2 Diabetes.

Biores Open Access 2019 25;8(1):59-64. Epub 2019 Mar 25.

Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts.

The contribution of pregnancy interval after gestational diabetes (GDM) to type 2 diabetes (T2DM) onset is a poorly understood but potentially modifiable factor for T2DM prevention. The purpose of this study was to assess the impact of GDM recurrence and/or delivery interval on follow-up care and T2DM onset in a sample of continuously insured women with a term livebirth within 3 years of a GDM-affected delivery. This is a secondary analysis of a cohort of 12,622 women with GDM, 2006-2012, drawn from a national administrative data system (OptumLabs Data Warehouse). Read More

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http://dx.doi.org/10.1089/biores.2018.0043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437620PMC
March 2019
2 Reads

Patent Application Trends of Induced Pluripotent Stem Cell Technologies in the United States, Japanese, and European Applications.

Biores Open Access 2019 19;8(1):45-58. Epub 2019 Mar 19.

Department of Regenerative Medicine and Stem Cell Biology, School of Medicine, Fujita Health University, Toyoake, Japan.

Patent application trends were investigated for induced pluripotent stem cell (iPSC) technologies, particularly disease-specific cell technologies related to iPSCs, in the U.S., Japanese, and European applications during 2017. Read More

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http://dx.doi.org/10.1089/biores.2018.0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428227PMC
March 2019
6 Reads

Combination of Treatments With or Without Surgery in Localized Provoked Vulvodynia: Outcomes After Three Years of Follow-Up.

Biores Open Access 2019 8;8(1):25-31. Epub 2019 Mar 8.

Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Most vulvodynia patients receive combinations of several treatment modalities for their chronic painful condition. If conservative treatments fail, vestibulectomy is considered to be the ultimate treatment option for localized provoked vulvodynia (LPV). The aim of this descriptive study was to analyze relief of pain, quality of life (QoL), and complications associated with combining surgery with conservative treatments among LPV patients, both in short term and after 3 years of follow-up. Read More

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http://dx.doi.org/10.1089/biores.2018.0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415354PMC
March 2019
2 Reads

Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia.

Biores Open Access 2019 1;8(1):16-24. Epub 2019 Mar 1.

Liggins Institute, University of Auckland, Auckland, New Zealand.

This study compared the effects of a high-calcium vitamin D fortified milk with added FOS-Inulin versus regular milk on serum parathyroid hormone (PTH), vitamin D status, grip strength (GS), as well as bone density in Chinese premenopausal women over 52 weeks. Premenopausal women ( = 133), mean age 41 (±5.1) years were randomized into control ( = 66; regular milk at 500 mg calcium per day) or intervention (Int;  = 67; fortified milk at 1200 mg calcium, 15 μg vitamin D, and 4 g FOS-Inulin per day) groups. Read More

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http://dx.doi.org/10.1089/biores.2018.0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400229PMC
March 2019
2 Reads

Vascular Tissue Engineering Using Scaffold-Free Prevascular Endothelial-Fibroblast Constructs.

Biores Open Access 2019 8;8(1):1-15. Epub 2019 Jan 8.

Department of Surgery, Medical University of South Carolina, Charleston, South Carolina.

Vascularization remains a substantial limitation to the viability of engineered tissue. By comparing vascularization dynamics of a self-assembled prevascular endothelial-fibroblast model to avascular grafts, we explore the vascularization rate limitations in implants at early time intervals, during which tissue hypoxia begins to affect cell viability. Scaffold-free prevascular endothelial-fibroblast constructs (SPECs) may serve as a modular and reshapable vascular bed in replacement tissues. Read More

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https://www.liebertpub.com/doi/10.1089/biores.2018.0039
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http://dx.doi.org/10.1089/biores.2018.0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327854PMC
January 2019
1 Read

The Impact of Different High-Intensity Interval Training Protocols on Body Composition and Physical Fitness in Healthy Young Adult Females.

Biores Open Access 2018 28;7(1):177-185. Epub 2018 Dec 28.

School of Health Sciences, Oakland University, Rochester, Michigan.

Although traditional high-intensity interval training (HIIT) has been effective in improving body composition and physical fitness, it is unclear how multimodal HIIT affects these variables. This study compared the differences between these two training programs on body composition and physical fitness in apparently healthy, nonobese young adult females. A total of 16 participants (mean age = 23 ± 5. Read More

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http://dx.doi.org/10.1089/biores.2018.0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323591PMC
December 2018
3 Reads

Activity Tracking Devices in Group Prenatal Care: A Feasibility Study.

Biores Open Access 2018 28;7(1):165-176. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.

To evaluate the feasibility (adherence to the study protocol and satisfaction) of using an activity tracking device (ATD) in group prenatal care. Women participated if they (1) were in group prenatal care, (2) owned a smartphone, and (3) had no activity restrictions. Women were instructed to wear and sync the ATD daily. Read More

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http://dx.doi.org/10.1089/biores.2018.0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267286PMC
November 2018
5 Reads

Diagnosis and Management of an Adenomatoid Uterine Tumor: Ultrasound, Magnetic Resonance Imaging, Surgical Appearance, and Pathology Correlation.

Biores Open Access 2018 26;7(1):159-164. Epub 2018 Oct 26.

Department of Obstetrics and Gynecology and Texas Tech University Health Sciences Center, Lubbock, Texas.

Adenomatoid uterine tumors are rare, and their appearance on medical imaging modalities is not well established. We present a case of an adenomatoid uterine tumor reviewing a unique sonographic presentation, magnetic resonance imaging (MRI), gross surgical appearance of the tumor, and microscopic pathology images. A 29-year-old gravida 0 Caucasian woman presented with dysmenorrhea, menorrhagia, and desire to conceive. Read More

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http://dx.doi.org/10.1089/biores.2018.0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206546PMC
October 2018
9 Reads

Lean Body Mass in the Prediction of Bone Mineral Density in Postmenopausal Women.

Biores Open Access 2018 10;7(1):150-158. Epub 2018 Oct 10.

School of Food and Nutrition, Massey University, Palmerston North, New Zealand.

Owing to conflicting results of the association between body composition and bone mineral density (BMD), we investigated the relationship between fat mass (FM), lean mass (LM), and BMD in New Zealand postmenopausal women. We hypothesized that increased LM will indicate a higher BMD. A cross-sectional study was performed examining the associations between body composition, anthropometric measures, activity energy expenditure, and bone health status (using dual-energy X-ray absorptiometry [DXA]). Read More

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https://www.liebertpub.com/doi/10.1089/biores.2018.0025
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http://dx.doi.org/10.1089/biores.2018.0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188582PMC
October 2018
4 Reads

Efficacy of Adjunctive Hyperbaric Oxygen Therapy in Osteoradionecrosis.

Biores Open Access 2018 8;7(1):145-149. Epub 2018 Oct 8.

Hospital Hyperbaric Oxygen Therapy Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Osteoradionecrosis (ORN) is a common consequence resulting from radiation in patients with cancer. Presently, hyperbaric oxygen therapy (HBOT) is proposed to have a role in improving wound healing in ORN patients. There is no strong scientific evidence to confirm the benefits of HBOT for treatment of ORN as an adjunctive treatment. Read More

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https://www.liebertpub.com/doi/10.1089/biores.2018.0019
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http://dx.doi.org/10.1089/biores.2018.0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178923PMC
October 2018
39 Reads

Breast Cancer Risk Among Women in Jail.

Biores Open Access 2018 20;7(1):139-144. Epub 2018 Sep 20.

Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, Kansas.

Over 200,000 women are diagnosed with breast cancer each year, and incarcerated women face unique risks associated with poor access to healthcare. Regular mammography can diagnose breast cancer early, giving the patient the best chance of survival. The objective of this study was to determine the proportion of jail incarcerated women who have received a mammogram and were up-to-date based on the most recent United States Preventive Services Task Force recommendations. Read More

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http://dx.doi.org/10.1089/biores.2018.0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151327PMC
September 2018
39 Reads

What's the Risk? Older Women Report Fewer Symptoms for Suspected Acute Coronary Syndrome than Younger Women.

Biores Open Access 2018 18;7(1):131-138. Epub 2018 Sep 18.

School of Nursing, University of North Carolina, Chapel Hill, North Carolina.

The purpose of the study was to determine whether older (≥65 years) and younger (<65 years) women presenting to the emergency department (ED) with symptoms suggestive of acute coronary syndrome (ACS) varied on risk factors, comorbid conditions, functional status, and symptoms that have implications for emergent cardiac care. Women admitted to five EDs were enrolled. The ACS Symptom Checklist was used to measure symptoms. Read More

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http://dx.doi.org/10.1089/biores.2018.0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146306PMC
September 2018
42 Reads

Circulating Levels of Bone and Inflammatory Markers in Gestational Diabetes Mellitus.

Biores Open Access 2018 1;7(1):123-130. Epub 2018 Aug 1.

Division of Endocrinology Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York.

Gestational diabetes mellitus (GDM) can cause short- and long-term complications to the mother and fetus. While the precise mechanisms in preserving glucose balance in a healthy pregnancy are unknown, various growth factors and hormones have been implicated or associated with GDM risk in humans or rodents, including prolactin, tumor necrosis factor alpha (TNFα), osteoprotegerin (OPG), hepatocyte growth factor (HGF), and receptor activator of nuclear factor-kappa B ligand (RANKL). We aimed to evaluate the relationship of these and other protein markers in women with GDM. Read More

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http://dx.doi.org/10.1089/biores.2018.0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106713PMC
August 2018
3 Reads

Impact of Central Obesity on Women with Polycystic Ovary Syndrome Undergoing Fertilization.

Biores Open Access 2018 1;7(1):116-122. Epub 2018 Aug 1.

Department of Gynecology and Obstetrics, Reproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Central obesity (CO) is a defining characteristic of polycystic ovary syndrome (PCOS) and PCOS-induced disorders are likely to be exacerbated in the presence of CO. This study aims to evaluate the impact of CO on infertile women with PCOS undergoing fertilization (IVF).It is a retrospective and case-control study. Read More

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http://dx.doi.org/10.1089/biores.2017.0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076435PMC
August 2018
7 Reads

A New Approach to Treating Neurodegenerative Otologic Disorders.

Biores Open Access 2018 1;7(1):107-115. Epub 2018 Jul 1.

ShangPharma Innovation, Inc., South San Francisco, California.

Hearing loss, the most common neurological disorder and the fourth leading cause of years lived with disability, can have profound effects on quality of life. The impact of this "invisible disability," with significant consequences, economic and personal, is most substantial in low- and middle-income countries, where >80% of affected people live. Given the importance of hearing for communication, enjoyment, and safety, with up to 500 million affected globally at a cost of nearly $800 billion/year, research on new approaches toward prevention and treatment is attracting increased attention. Read More

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http://dx.doi.org/10.1089/biores.2018.0017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069589PMC
July 2018
12 Reads

Canine Placenta Recellularized Using Yolk Sac Cells with Vascular Endothelial Growth Factor.

Biores Open Access 2018 1;7(1):101-106. Epub 2018 Jul 1.

Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.

Regenerative medicine has been growing because of the emergent need for tissues/organs for transplants and restorative surgeries. Biological scaffolds are important tools to try to solve this problem. The one used in this reserach was developed by an acellular biological scaffold from canine placenta with a rich source of cellular matrix. Read More

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http://dx.doi.org/10.1089/biores.2018.0014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056259PMC
July 2018
32 Reads