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    1323 results match your criteria BioMedical Engineering OnLine [Journal]

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    Study of correlation between wall shear stress and elasticity in atherosclerotic carotid arteries.
    Biomed Eng Online 2018 Jan 16;17(1). Epub 2018 Jan 16.
    University 2020 Foundation, Northborough, MA, 01532, USA.
    Objective: This paper presents the use of the texture matching method to measure the rabbit carotid artery elasticity value of the experimental group and control group respectively. It compares the experimental rabbits, when they are prompted by pathological histology to be at the period of carotid atherosclerosis fatty streaks and fiber plaques, with the control group.

    Methods: We have used ultrasound linear array probe for scanning the rabbit carotid arteries. Read More

    Computational study of the effects of arterial bifurcation on the temperature distribution during cryosurgery.
    Biomed Eng Online 2018 Jan 16;17(1). Epub 2018 Jan 16.
    Vehicle Engineering, College of Engineering, China Agricultural University, Beijing, 100083, China.
    Background: Thermally significant blood flows into locally cooled diseased tissues and warm them during cryosurgery so that the iceball is often hard to cover the whole diseased volume. This paper is aimed at investigating the effects of large arterial bifurcation on the temperature distribution during cryosurgery through simulation method.

    Methods: A parametric geometry model is introduced to construct a close-to-real arterial bifurcation. Read More

    Generalized estimation of the ventilatory distribution from the multiple-breath washout: a bench evaluation study.
    Biomed Eng Online 2018 Jan 15;17(1). Epub 2018 Jan 15.
    Pulmonary Engineering Laboratory, Biomedical Engineering Programme, COPPE, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: The multiple-breath washout (MBW) is able to provide information about the distribution of ventilation-to-volume (v/V) ratios in the lungs. However, the classical, all-parallel model may return skewed results due to the mixing effect of a common dead space. The aim of this work is to examine whether a novel mathematical model and algorithm is able to estimate v/V of a physical model, and to compare its results with those of the classical model. Read More

    Perspectives on setting limits for RF contact currents: a commentary.
    Biomed Eng Online 2018 Jan 15;17(1). Epub 2018 Jan 15.
    Richard Tell Associates, Inc., 350 Falcon Ridge Parkway, Suite 103, Mesquite, NV, 89027, USA.
    Background: Limits for exposure to radiofrequency (RF) contact currents are specified in the two dominant RF safety standards and guidelines developed by the Institute of Electrical and Electronics Engineers (IEEE) and the International Commission on Non-Ionizing Radiation Protection (ICNIRP). These limits are intended to prevent RF burns when contacting RF energized objects caused by high local tissue current densities. We explain what contact currents are and review some history of the relevant limits with an emphasis on so-called "touch" contacts, i. Read More

    Temperature elevation in the human brain and skin with thermoregulation during exposure to RF energy.
    Biomed Eng Online 2018 Jan 8;17(1). Epub 2018 Jan 8.
    Department of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Nagoya, 466-8555, Japan.
    Background: Two international guidelines/standards for human protection from electromagnetic fields define the specific absorption rate (SAR) averaged over 10 g of tissue as a metric for protection against localized radio frequency field exposure due to portable devices operating below 3-10 GHz. Temperature elevation is suggested to be a dominant effect for exposure at frequencies higher than 100 kHz. No previous studies have evaluated temperature elevation in the human head for local exposure considering thermoregulation. Read More

    Investigation of red blood cell mechanical properties using AFM indentation and coarse-grained particle method.
    Biomed Eng Online 2017 Dec 19;16(1):140. Epub 2017 Dec 19.
    Science and Engineering Faculty, Queensland University of Technology (QUT), Brisbane, 4000, Australia.
    Background: Red blood cells (RBCs) deform significantly and repeatedly when passing through narrow capillaries and delivering dioxygen throughout the body. Deformability of RBCs is a key characteristic, largely governed by the mechanical properties of the cell membrane. This study investigated RBC mechanical properties using atomic force microscopy (AFM) with the aim to develop a coarse-grained particle method model to study for the first time RBC indentation in both 2D and 3D. Read More

    R-wave synchronised atrial pacing in pediatric patients with postoperative junctional ectopic tachycardia: the atrioventricular interval investigated by computational analysis and clinical evaluation.
    Biomed Eng Online 2017 Dec 19;16(1):139. Epub 2017 Dec 19.
    Department of Pediatric Cardiology, University of Leipzig, Strümpellstrasse 39, 04289, Leipzig, Germany.
    Background: R-wave synchronised atrial pacing is an effective temporary pacing therapy in infants with postoperative junctional ectopic tachycardia. In the technique currently used, adverse short or long intervals between atrial pacing and ventricular sensing (AP-VS) may be observed during routine clinical practice.

    Objectives: The aim of the study was to analyse outcomes of R-wave synchronised atrial pacing and the relationship between maximum tracking rates and AP-VS intervals. Read More

    A finite element model of the lower limb during stance phase of gait cycle including the muscle forces.
    Biomed Eng Online 2017 Dec 7;16(1):138. Epub 2017 Dec 7.
    Department of Orthopedic Surgery, Centre Hospitalier de Luxembourg, 76 Rue d'Eich, 1460, Luxembourg, Luxembourg.
    Background: Results of finite element (FE) analyses can give insight into musculoskeletal diseases if physiological boundary conditions, which include the muscle forces during specific activities of daily life, are considered in the FE modelling. So far, many simplifications of the boundary conditions are currently made. This study presents an approach for FE modelling of the lower limb for which muscle forces were included. Read More

    Correlation between quantitative analysis of wall shear stress and intima-media thickness in atherosclerosis development in carotid arteries.
    Biomed Eng Online 2017 Dec 6;16(1):137. Epub 2017 Dec 6.
    University 2020 Foundation, Northborough, MA, 01532, USA.
    Background: This paper presents quantitative analysis of blood flow shear stress by measuring the carotid arterial wall shear stress (WSS) and the intima-media thickness (IMT) of experimental rabbits fed with high-fat feedstuff on a weekly basis in order to cause atherosclerosis.

    Methods: This study is based on establishing an atherosclerosis model of high-fat rabbits, and measuring the rabbits' common carotid arterial WSS of the experimental group and control group on a weekly basis. Detailed analysis was performed by using WSS quantification. Read More

    Application of two-parameter scoliometer values for predicting scoliotic Cobb angle.
    Biomed Eng Online 2017 Dec 4;16(1):136. Epub 2017 Dec 4.
    Department of Orthopaedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital at Linkou, 5 Fushing St. Kweishan, Taoyuan, 33305, Taiwan.
    Background: Adolescent idiopathic scoliosis, in which obvious curves are visible in radiographic images, is also seen in combination with lumps in the back. These lumps contribute to inclination, which can be measured by a scoliometer. To the authors' knowledge, there are no previous formulas combining thoracic and lumbar scoliometer values simultaneously to predict thoracic and lumbar Cobb angles, respectively. Read More

    Image-based quantitative analysis of tear film lipid layer thickness for meibomian gland evaluation.
    Biomed Eng Online 2017 Nov 23;16(1):135. Epub 2017 Nov 23.
    Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology (GIST), 123 Cheomdan-gwagiro, Buk-gu, Gwangju, 61005, Korea.
    Background: Dry eye syndrome is one of the most common ocular diseases, and meibomian gland dysfunction (MGD) is the leading cause of evaporative dry eye syndrome. When the tear film lipid layer becomes thin due to obstructive or hyposecretory meibomian gland dysfunction, the excessive evaporation of the aqueous layer can occur, and this causes evaporative dry eye syndrome. Thus, measuring the lipid layer thickness (LLT) is essential for accurate diagnosis and proper treatment of evaporative dry eye syndrome. Read More

    Differentiation of human adipose-derived stem cells into cardiomyocyte-like cells in fibrin scaffold by a histone deacetylase inhibitor.
    Biomed Eng Online 2017 Nov 23;16(1):134. Epub 2017 Nov 23.
    Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
    Background: Human adipose-derived stem cells (hADSCs) are capable of differentiating into many cells such as cardiac cells. Different types of inducers are used for cardiac cell differentiation, but this question still remains to be investigated, which one is the best. The aim of this paper was to investigate the effect of combination of fibrin scaffold and trichostatin A (TSA), for differentiation of hADSCs into cardiomyocyte-like cells. Read More

    Automatic diagnosis of imbalanced ophthalmic images using a cost-sensitive deep convolutional neural network.
    Biomed Eng Online 2017 Nov 21;16(1):132. Epub 2017 Nov 21.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Xian Lie South Road 54#, Guangzhou, 510060, China.
    Background: Ocular images play an essential role in ophthalmological diagnoses. Having an imbalanced dataset is an inevitable issue in automated ocular diseases diagnosis; the scarcity of positive samples always tends to result in the misdiagnosis of severe patients during the classification task. Exploring an effective computer-aided diagnostic method to deal with imbalanced ophthalmological dataset is crucial. Read More

    Evaluation of normal swallowing functions by using dynamic high-density surface electromyography maps.
    Biomed Eng Online 2017 Nov 21;16(1):133. Epub 2017 Nov 21.
    Chinese Academy of Science (CAS) Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Shenzhen, 518055, China.
    Background: Swallowing is a continuous process with substantive interdependencies among different muscles, and it plays a significant role in our daily life. The aim of this study was to propose a novel technique based on high-density surface electromyography (HD sEMG) for the evaluation of normal swallowing functions.

    Methods: A total of 96 electrodes were placed on the front neck to acquire myoelectric signals from 12 healthy subjects while they were performing different swallowing tasks. Read More

    A customized fixation plate with novel structure designed by topological optimization for mandibular angle fracture based on finite element analysis.
    Biomed Eng Online 2017 Nov 15;16(1):131. Epub 2017 Nov 15.
    Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
    Background: The purpose of this study was to design a customized fixation plate for mandibular angle fracture using topological optimization based on the biomechanical properties of the two conventional fixation systems, and compare the results of stress, strain and displacement distributions calculated by finite element analysis (FEA).

    Methods: A three-dimensional (3D) virtual mandible was reconstructed from CT images with a mimic angle fracture and a 1 mm gap between two bone segments, and then a FEA model, including volume mesh with inhomogeneous bone material properties, three loading conditions and constraints (muscles and condyles), was created to design a customized plate using topological optimization method, then the shape of the plate was referenced from the stress concentrated area on an initial part created from thickened bone surface for optimal calculation, and then the plate was formulated as "V" pattern according to dimensions of standard mini-plate finally. To compare the biomechanical behavior of the "V" plate and other conventional mini-plates for angle fracture fixation, two conventional fixation systems were used: type A, one standard mini-plate, and type B, two standard mini-plates, and the stress, strain and displacement distributions within the three fixation systems were compared and discussed. Read More

    A medium invasiveness multi-level patient's specific template for pedicle screw placement in the scoliosis surgery.
    Biomed Eng Online 2017 Nov 14;16(1):130. Epub 2017 Nov 14.
    Pediatric Neurorehabilitation Research Center, Ergonomics Department, University of Social Welfare and Rehabilitation Sciences (USWR), Tehran, Iran.
    Background: Several methods including free-hand technique, fluoroscopic guidance, image-guided navigation, computer-assisted surgery system, robotic platform and patient's specific templates are being used for pedicle screw placement. These methods have screw misplacements and are not always easy to be applied. Furthermore, it is necessary to expose completely a large portions of the spine in order to access fit entirely around the vertebrae. Read More

    NeoAnalysis: a Python-based toolbox for quick electrophysiological data processing and analysis.
    Biomed Eng Online 2017 Nov 13;16(1):129. Epub 2017 Nov 13.
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.
    Background: In a typical electrophysiological experiment, especially one that includes studying animal behavior, the data collected normally contain spikes, local field potentials, behavioral responses and other associated data. In order to obtain informative results, the data must be analyzed simultaneously with the experimental settings. However, most open-source toolboxes currently available for data analysis were developed to handle only a portion of the data and did not take into account the sorting of experimental conditions. Read More

    Portable wireless neurofeedback system of EEG alpha rhythm enhances memory.
    Biomed Eng Online 2017 Nov 13;16(1):128. Epub 2017 Nov 13.
    Department of Psychology, National Cheng Kung University, Tainan, Taiwan.
    Background: Effect of neurofeedback training (NFT) on enhancement of cognitive function or amelioration of clinical symptoms is inconclusive. The trainability of brain rhythm using a neurofeedback system is uncertainty because various experimental designs are used in previous studies. The current study aimed to develop a portable wireless NFT system for alpha rhythm and to validate effect of the NFT system on memory with a sham-controlled group. Read More

    Hemodynamics analysis of the serial stenotic coronary arteries.
    Biomed Eng Online 2017 Nov 9;16(1):127. Epub 2017 Nov 9.
    Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Ave., Xili University Town, Nanshan, Shenzhen, 518055, Guangdong, China.
    Coronary arterial stenoses, particularly serial stenoses in a single branch, are responsible for complex hemodynamic properties of the coronary arterial trees, and the uncertain prognosis of invasive intervention. Critical information of the blood flow redistribution in the stenotic arterial segments is required for the adequate treatment planning. Therefore, in this study, an image based non-invasive functional assessment is performed to investigate the hemodynamic significances of serial stenoses. Read More

    Empirical study of seven data mining algorithms on different characteristics of datasets for biomedical classification applications.
    Biomed Eng Online 2017 Nov 2;16(1):125. Epub 2017 Nov 2.
    Department of Biomedical Engineering, School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China.
    Background: Various kinds of data mining algorithms are continuously raised with the development of related disciplines. The applicable scopes and their performances of these algorithms are different. Hence, finding a suitable algorithm for a dataset is becoming an important emphasis for biomedical researchers to solve practical problems promptly. Read More

    Prediction of high airway pressure using a non-linear autoregressive model of pulmonary mechanics.
    Biomed Eng Online 2017 Nov 2;16(1):126. Epub 2017 Nov 2.
    Department of Mechanical Engineering, University of Canterbury, Private bag 4800, Christchurch, 8140, New Zealand.
    Background: For mechanically ventilated patients with acute respiratory distress syndrome (ARDS), suboptimal PEEP levels can cause ventilator induced lung injury (VILI). In particular, high PEEP and high peak inspiratory pressures (PIP) can cause over distension of alveoli that is associated with VILI. However, PEEP must also be sufficient to maintain recruitment in ARDS lungs. Read More

    Global Patch Matching (GPM) for freehand 3D ultrasound reconstruction.
    Biomed Eng Online 2017 Oct 30;16(1):124. Epub 2017 Oct 30.
    Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Electronics, Beijing Institute of Technology, Beijing, 100081, China.
    Background: 3D ultrasound volume reconstruction from B-model ultrasound slices can provide more clearly and intuitive structure of tissue and lesion for the clinician.

    Methods: This paper proposes a novel Global Path Matching method for the 3D reconstruction of freehand ultrasound images. The proposed method composes of two main steps: bin-filling scheme and hole-filling strategy. Read More

    Near field effect on elasticity measurement for cartilage-bone structure using Lamb wave method.
    Biomed Eng Online 2017 Oct 30;16(1):123. Epub 2017 Oct 30.
    Orthopaedic Institute, Department of Orthopaedics, the First Affiliated Hospital, Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
    Background: Cartilage elasticity changes with cartilage degeneration. Hence, cartilage elasticity detection might be an alternative to traditional imaging methods for the early diagnosis of osteoarthritis. Based on the wave propagation measurement, Shear wave elastography (SWE) become an emerging non-invasive elasticity detection method. Read More

    Automatic non-proliferative diabetic retinopathy screening system based on color fundus image.
    Biomed Eng Online 2017 Oct 26;16(1):122. Epub 2017 Oct 26.
    Tianjin Medical University Metabolic Diseases Hospital, Tianjin, 300070, China.
    Background: Non-proliferative diabetic retinopathy is the early stage of diabetic retinopathy. Automatic detection of non-proliferative diabetic retinopathy is significant for clinical diagnosis, early screening and course progression of patients.

    Methods: This paper introduces the design and implementation of an automatic system for screening non-proliferative diabetic retinopathy based on color fundus images. Read More

    Paroxysmal atrial fibrillation recognition based on multi-scale wavelet α-entropy.
    Biomed Eng Online 2017 Oct 23;16(1):121. Epub 2017 Oct 23.
    Department of Biomedical Engineering, Beijing Institute of Technology, Beijing, 100081, China.
    Background: This study proposed an effective method based on the wavelet multi-scale α-entropy features of heart rate variability (HRV) for the recognition of paroxysmal atrial fibrillation (PAF). This new algorithm combines wavelet decomposition and non-linear analysis methods. The PAF signal, the signal distant from PAF, and the normal sinus signals can be identified and distinguished by extracting the characteristic parameters from HRV signals and analyzing their quantification indexes. Read More

    STAMPS: development and verification of swallowing kinematic analysis software.
    Biomed Eng Online 2017 Oct 17;16(1):120. Epub 2017 Oct 17.
    Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
    Background: Swallowing impairment is a common complication in various geriatric and neurodegenerative diseases. Swallowing kinematic analysis is essential to quantitatively evaluate the swallowing motion of the oropharyngeal structures. This study aims to develop a novel swallowing kinematic analysis software, called spatio-temporal analyzer for motion and physiologic study (STAMPS), and verify its validity and reliability. Read More

    Solar UV exposure among outdoor workers in Denmark measured with personal UV-B dosimeters: technical and practical feasibility.
    Biomed Eng Online 2017 Oct 10;16(1):119. Epub 2017 Oct 10.
    The Danish Meteorological Institute, Copenhagen, Denmark.
    Background: Exposure to solar ultraviolet radiation is a well-known cause of skin cancer. This is problematic for outdoor workers. In Denmark alone, occupational skin cancer poses a significant health and safety risk for around 400,000 outdoor workers. Read More

    Low-power transcutaneous current stimulator for wearable applications.
    Biomed Eng Online 2017 Oct 3;16(1):118. Epub 2017 Oct 3.
    The MARCS Institute for Brain, Behaviour and Development, Western Sydney University, Bullecourt Avenue, Milperra, Sydney, Australia.
    Background: Peripheral neuropathic desensitization associated with aging, diabetes, alcoholism and HIV/AIDS, affects tens of millions of people worldwide, and there is little or no treatment available to improve sensory function. Recent studies that apply imperceptible continuous vibration or electrical stimulation have shown promise in improving sensitivity in both diseased and healthy participants. This class of interventions only has an effect during application, necessitating the design of a wearable device for everyday use. Read More

    Diabetic foot ulcer mobile detection system using smart phone thermal camera: a feasibility study.
    Biomed Eng Online 2017 Oct 3;16(1):117. Epub 2017 Oct 3.
    Electrical and Computer Engineering Deparment, Abu Dhabi University, 59911, Abu Dhabi, United Arab Emirates.
    Background: Nowadays, the whole world is being concerned with a major health problem, which is diabetes. A very common symptom of diabetes is the diabetic foot ulcer (DFU). The early detection of such foot complications can protect diabetic patients from any dangerous stages that develop later and may require foot amputation. Read More

    Study of the variations of fall induced hip fracture risk between right and left femurs using CT-based FEA.
    Biomed Eng Online 2017 Oct 3;16(1):116. Epub 2017 Oct 3.
    Department of Mechanical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.
    Background: Hip fracture of elderly people-suffering from osteoporosis-is a severe public health concern, which can be reduced by providing a prior assessment of hip fracture risk. Image-based finite element analysis (FEA) has been considered an effective computational tool to assess the hip fracture risk. Considering the femoral neck region is the weakest, fracture risk indicators (FRI) are evaluated for both single-legged stance and sideways fall configurations and are compared between left and right femurs of each subject. Read More

    Biosignals learning and synthesis using deep neural networks.
    Biomed Eng Online 2017 Sep 25;16(1):115. Epub 2017 Sep 25.
    LIBPhys (Laboratory for Instrumentation, Biomedical Engineering and Radiation Physics), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516, Caparica, Portugal.
    Background: Modeling physiological signals is a complex task both for understanding and synthesize biomedical signals. We propose a deep neural network model that learns and synthesizes biosignals, validated by the morphological equivalence of the original ones. This research could lead the creation of novel algorithms for signal reconstruction in heavily noisy data and source detection in biomedical engineering field. Read More

    Building a resistance to ignition testing device for sunglasses and analysing data: a continuing study for sunglasses standards.
    Biomed Eng Online 2017 Sep 21;16(1):114. Epub 2017 Sep 21.
    Electrical Engineering Department, Engineering School of São Carlos, University of São Paulo, Av. Trabalhador Sãocarlense 400, São Carlos, SP, 13566-590, Brazil.
    Background: Sunglasses popularity skyrocketed since its advent. The ongoing trend led to the creation of standards to protect consumers from injuries and secondary hazards due to spectacles use. In Brazil, the corresponding standard is NBR ISO 12312-1:2015 and since there is no mandatory testing, evaluating sunglasses performance provides an insight into compliance with the standard. Read More

    Area asymmetry of heart rate variability signal.
    Biomed Eng Online 2017 Sep 21;16(1):112. Epub 2017 Sep 21.
    School of Control Science and Engineering, Shandong University, Jinan, 250061, China.
    Background: Heart rate fluctuates beat-by-beat asymmetrically which is known as heart rate asymmetry (HRA). It is challenging to assess HRA robustly based on short-term heartbeat interval series.

    Method: An area index (AI) was developed that combines the distance and phase angle information of points in the Poincaré plot. Read More

    Parameters sensitivity assessment and heat source localization using infrared imaging techniques.
    Biomed Eng Online 2017 Sep 21;16(1):113. Epub 2017 Sep 21.
    Department of Electrical and Computer Engineering, Ryerson University, 350 Victoria St, Toronto, ON, M5B 2K3, Canada.
    Background: At present, infrared (IR) imaging is used both as a non-invasive and a non-ionizing technology. Using an IR camera, it is possible to measure body surface temperature in order to detect tumors and malignant cells. Tumors have a high amount of vasculature and an enhanced metabolism rate, which may result in an increase in body surface temperature by several degrees above its normal level. Read More

    Automatic sleep staging using ear-EEG.
    Biomed Eng Online 2017 Sep 19;16(1):111. Epub 2017 Sep 19.
    Department of Engineering, Aarhus University, Finlandsgade 22, 8200, Aarhus N, Denmark.
    Background: Sleep and sleep quality assessment by means of sleep stage analysis is important for both scientific and clinical applications. Unfortunately, the presently preferred method, polysomnography (PSG), requires considerable expert assistance and significantly affects the sleep of the person under observation. A reliable, accurate and mobile alternative to the PSG would make sleep information much more readily available in a wide range of medical circumstances. Read More

    SinusCor: an advanced tool for heart rate variability analysis.
    Biomed Eng Online 2017 Sep 18;16(1):110. Epub 2017 Sep 18.
    Pulmonary Engineering Laboratory, Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Cidade Universitária, Rio de Janeiro, Brazil.
    Background: Heart rate variability (HRV) is a widespread non-invasive technique to assess cardiac autonomic function. Time and frequency domain analyses have been used in HRV studies, and their interpretations are linked with both clinical prognostic and diagnostic information. Statistical and geometrical parameters, Fast Fourier Transform and Autoregressive based periodograms are commonly used approaches for the assessment of stationary RR intervals (RRi) signals. Read More

    Implementation and validation of the extended Hill-type muscle model with robust routing capabilities in LS-DYNA for active human body models.
    Biomed Eng Online 2017 Sep 2;16(1):109. Epub 2017 Sep 2.
    Biomechanics and Biorobotics, Stuttgart Research Centre for Simulation Sciences (SRC SimTech), University of Stuttgart, Allmandring 28, 70569, Stuttgart, Germany.
    Background: In the state of the art finite element AHBMs for car crash analysis in the LS-DYNA software material named *MAT_MUSCLE (*MAT_156) is used for active muscles modeling. It has three elements in parallel configuration, which has several major drawbacks: restraint approximation of the physical reality, complicated parameterization and absence of the integrated activation dynamics. This study presents implementation of the extended four element Hill-type muscle model with serial damping and eccentric force-velocity relation including [Formula: see text] dependent activation dynamics and internal method for physiological muscle routing. Read More

    Evaluation of the effect of different sitting assistive devices in reclining wheelchair on interface pressure.
    Biomed Eng Online 2017 Aug 29;16(1):108. Epub 2017 Aug 29.
    Applied Biomechanics Laboratory, Graduate Institute of Mechatronic System Engineering, National University of Tainan, No. 33, Sec. 2, Shu-Lin St., West Central Dist., Tainan, 70005, Taiwan.
    Background: Reclining wheelchair users often add one or more sitting assistive devices to their wheelchairs, but the effect of these additional sitting assistive devices on the risk of pressure ulcers has rarely been investigated. This study examined the four modes of reclining wheelchair without and with different sitting assistive devices, namely the back reclined mode, the lumbar support with back reclined mode, the femur upward with back reclined mode, and the lumbar support with femur upward with back reclined mode, in terms of their effects on human-wheelchair interface pressure.

    Methods: This study recruited 16 healthy participants to undergo the aforementioned four modes in random order and have their human-wheelchair interface pressure measured. Read More

    Noise-assisted multivariate empirical mode decomposition for multichannel EMG signals.
    Biomed Eng Online 2017 Aug 23;16(1):107. Epub 2017 Aug 23.
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, No. 4, Section 2 of North Jianshe Road, Chengdu, 610054, China.
    Background: Ensemble Empirical Mode Decomposition (EEMD) has been popularised for single-channel Electromyography (EMG) signal processing as it can effectively extract the temporal information of the EMG time series. However, few papers examine the temporal and spatial characteristics across multiple muscle groups in relation to multichannel EMG signals.

    Experiment: The experimental data was obtained from the Center for Machine Learning and Intelligent Systems, University of California Irvine (UCI). Read More

    Evaluation of cervical posture improvement of children with cerebral palsy after physical therapy based on head movements and serious games.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):74. Epub 2017 Aug 18.
    Neural and Cognitive Engineering Group, Centre for Automation and Robotics (CAR) CSIC-UPM, Ctra. Campo Real Km 0.2, 28500, Arganda del Rey, Spain.
    Background: This paper presents the preliminary results of a novel rehabilitation therapy for cervical and trunk control of children with cerebral palsy (CP) based on serious videogames and physical exercise.

    Materials: The therapy is based on the use of the ENLAZA Interface, a head mouse based on inertial technology that will be used to control a set of serious videogames with movements of the head.

    Methods: Ten users with CP participated in the study. Read More

    A protocol for CABS-dock protein-peptide docking driven by side-chain contact information.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):73. Epub 2017 Aug 18.
    Faculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
    Background: The characterization of protein-peptide interactions is a challenge for computational molecular docking. Protein-peptide docking tools face at least two major difficulties: (1) efficient sampling of large-scale conformational changes induced by binding and (2) selection of the best models from a large set of predicted structures. In this paper, we merge an efficient sampling technique with external information about side-chain contacts to sample and select the best possible models. Read More

    Identification of informative features for predicting proinflammatory potentials of engine exhausts.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):66. Epub 2017 Aug 18.
    School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Background: The immunotoxicity of engine exhausts is of high concern to human health due to the increasing prevalence of immune-related diseases. However, the evaluation of immunotoxicity of engine exhausts is currently based on expensive and time-consuming experiments. It is desirable to develop efficient methods for immunotoxicity assessment. Read More

    Automated identification of reference genes based on RNA-seq data.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):65. Epub 2017 Aug 18.
    Departamento de Biología Molecular y Bioquímica, Universidad de Málaga, Malaga, Spain.
    Background: Gene expression analyses demand appropriate reference genes (RGs) for normalization, in order to obtain reliable assessments. Ideally, RG expression levels should remain constant in all cells, tissues or experimental conditions under study. Housekeeping genes traditionally fulfilled this requirement, but they have been reported to be less invariant than expected; therefore, RGs should be tested and validated for every particular situation. Read More

    Modeling EphB4-EphrinB2 protein-protein interaction using flexible docking of a short linear motif.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):71. Epub 2017 Aug 18.
    Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
    Background: Many protein-protein interactions are mediated by a short linear motif. Usually, amino acid sequences of those motifs are known or can be predicted. It is much harder to experimentally characterize or predict their structure in the bound form. Read More

    Feature ranking and rank aggregation for automatic sleep stage classification: a comparative study.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):78. Epub 2017 Aug 18.
    Computational Intelligence Group of CTS/UNINOVA, Caparica, Portugal.
    Background: Nowadays, sleep quality is one of the most important measures of healthy life, especially considering the huge number of sleep-related disorders. Identifying sleep stages using polysomnographic (PSG) signals is the traditional way of assessing sleep quality. However, the manual process of sleep stage classification is time-consuming, subjective and costly. Read More

    Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):72. Epub 2017 Aug 18.
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
    Background: A key challenge in the realm of human disease research is next generation sequencing (NGS) interpretation, whereby identified filtered variant-harboring genes are associated with a patient's disease phenotypes. This necessitates bioinformatics tools linked to comprehensive knowledgebases. The GeneCards suite databases, which include GeneCards (human genes), MalaCards (human diseases) and PathCards (human pathways) together with additional tools, are presented with the focus on MalaCards utility for NGS interpretation as well as for large scale bioinformatic analyses. Read More

    Transcranial direct current stimulation as a motor neurorehabilitation tool: an empirical review.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):76. Epub 2017 Aug 18.
    University of Almería, Almería, Spain.
    The present review collects the most relevant empirical evidence available in the literature until date regarding the effects of transcranial direct current stimulation (tDCS) on the human motor function. tDCS in a non-invasive neurostimulation technique that delivers a weak current through the brain scalp altering the cortical excitability on the target brain area. The electrical current modulates the resting membrane potential of a variety of neuronal population (as pyramidal and gabaergic neurons); raising or dropping the firing rate up or down, depending on the nature of the electrode and the applied intensity. Read More

    Influence of parameter perturbations on the reachability of therapeutic target in systems with switchings.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):77. Epub 2017 Aug 18.
    Silesian University of Technology, Akademicka 16, Gliwice, Poland.
    Background: Examination of physiological processes and the influences of the drugs on them can be efficiently supported by mathematical modeling. One of the biggest problems is related to the exact fitting of the parameters of a model. Conditions inside the organism change dynamically, so the rates of processes are very difficult to estimate. Read More

    Using random forests for assistance in the curation of G-protein coupled receptor databases.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):75. Epub 2017 Aug 18.
    Department of Computer Science, Universitat Politècnica de Catalunya, C. Jordi Girona, 1-3, 08034, Barcelona, Spain.
    Background: Biology is experiencing a gradual but fast transformation from a laboratory-centred science towards a data-centred one. As such, it requires robust data engineering and the use of quantitative data analysis methods as part of database curation. This paper focuses on G protein-coupled receptors, a large and heterogeneous super-family of cell membrane proteins of interest to biology in general. Read More

    Methodological factors affecting joint moments estimation in clinical gait analysis: a systematic review.
    Biomed Eng Online 2017 Aug 18;16(1):106. Epub 2017 Aug 18.
    Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza de Bosis 15, 00135, Rome, Italy.
    Quantitative gait analysis can provide a description of joint kinematics and dynamics, and it is recognized as a clinically useful tool for functional assessment, diagnosis and intervention planning. Clinically interpretable parameters are estimated from quantitative measures (i.e. Read More

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