1,551 results match your criteria BioMedical Engineering OnLine [Journal]


A concentric tube-based 4-DOF puncturing needle with a novel miniaturized actuation system for vitrectomy.

Biomed Eng Online 2019 Apr 18;18(1):46. Epub 2019 Apr 18.

Department of Mechanical Engineering, Chonnam National University, Gwangju, 61186, South Korea.

Background: Vitreoretinal surgeries require precise, dexterous, and steady instruments for operation in delicate parts of the eye. Robotics has presented solutions for many vitreoretinal surgical problems, but, in a few operations, the available tools are still not dexterous enough to carry out procedures with minimum trauma to patients. Vitrectomy is one of those procedures and requires some dexterous instruments to replace straight ones for better navigation to affected sides inside the eyeball. Read More

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https://biomedical-engineering-online.biomedcentral.com/arti
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http://dx.doi.org/10.1186/s12938-019-0666-xDOI Listing
April 2019
1 Read

Retraction mechanics of Finochietto-style self-retaining thoracic retractors.

Biomed Eng Online 2019 Apr 16;18(1):45. Epub 2019 Apr 16.

Physcient Inc., 112 South Duke St., Suite 4A, Durham, NC, 27701, USA.

Objectives: Analyze the mechanics of Finochietto-style retractors, including the responses of thoracic tissues during thoracotomy, with an emphasis on tissue trauma and means for its reduction.

Methods: Mechanical analyses of the retractor were performed, including analysis of deformation under load and kinematics of the crank mechanism. Thoracotomies in a porcine model were performed in anesthetized animals (7) and fresh cadavers (17) using an instrumented retractor. Read More

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http://dx.doi.org/10.1186/s12938-019-0664-zDOI Listing
April 2019
2 Reads

Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses.

Biomed Eng Online 2019 Apr 8;18(1):44. Epub 2019 Apr 8.

Neuroengineering Lab, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, ETH Zürich, TAN E 2, Tannenstrasse 1, 8092, Zurich, Switzerland.

Background: The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the processing of descending efferent neural signals recorded using peripheral neural interfaces could be a solution to such limitation. Unfortunately, this choice is still restrained by the reduced knowledge of the dynamics of human efferent signals recorded from the nerves and associated to hand movements. Read More

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https://biomedical-engineering-online.biomedcentral.com/arti
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http://dx.doi.org/10.1186/s12938-019-0659-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454621PMC
April 2019
2 Reads

Continuous distraction osteogenesis device with MAAC controller for mandibular reconstruction applications.

Biomed Eng Online 2019 Apr 8;18(1):43. Epub 2019 Apr 8.

Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Distraction osteogenesis (DO) is a novel technique widely used in human body reconstruction. DO has got a significant role in maxillofacial reconstruction applications (MRA); through this method, bone defects and skeletal deformities in various cranio-maxillofacial areas could be reconstructed with superior results in comparison to conventional methods. Recent studies revealed in a DO solution, using an automatic continuous distractor could significantly improve the results while decreasing the existing issues. Read More

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http://dx.doi.org/10.1186/s12938-019-0655-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454606PMC
April 2019
1 Read
1.427 Impact Factor

Evaluation of corneal elastic modulus based on Corneal Visualization Scheimpflug Technology.

Biomed Eng Online 2019 Apr 4;18(1):42. Epub 2019 Apr 4.

Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, 100069, China.

Background: Corneal biomechanical properties are important for the diagnosis of corneal diseases, individualized design and prognosis of corneal surgery. Clinical available devices such as Ocular Response Analyzer (ORA) and Corneal Visualization Scheimpflug Technology (Corvis ST) can provide corneal biomechanics related parameters, while corneal elastic modulus cannot be extracted directly from them at present. The aim of this study is to suggest a method to determine corneal elastic modulus based on the results of Corvis ST test according to Reissner's theory on the relation between stress and small displacement in shallow spherical shell. Read More

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http://dx.doi.org/10.1186/s12938-019-0662-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449989PMC
April 2019
2 Reads

Mechanical analysis of a novel biodegradable zinc alloy stent based on a degradation model.

Biomed Eng Online 2019 Apr 2;18(1):39. Epub 2019 Apr 2.

Northeastern University, Shenyang, 110819, Liaoning, China.

Background: Biodegradable stents display insufficient scaffold performance due to their poor Young's Modulus. In addition, the corresponding biodegradable materials harbor weakened structures during degradation processes. Consequently, such stents have not been extensively applied in clinical therapy. Read More

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http://dx.doi.org/10.1186/s12938-019-0661-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444843PMC
April 2019
1 Read

A review on low-dimensional physics-based models of systemic arteries: application to estimation of central aortic pressure.

Biomed Eng Online 2019 Apr 2;18(1):41. Epub 2019 Apr 2.

Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, 110819, China.

The physiological processes and mechanisms of an arterial system are complex and subtle. Physics-based models have been proven to be a very useful tool to simulate actual physiological behavior of the arteries. The current physics-based models include high-dimensional models (2D and 3D models) and low-dimensional models (0D, 1D and tube-load models). Read More

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http://dx.doi.org/10.1186/s12938-019-0660-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446386PMC
April 2019
1 Read

On the protective capacity of a safety vest for the thoracic injury caused by falling down.

Biomed Eng Online 2019 Apr 2;18(1):40. Epub 2019 Apr 2.

School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, People's Republic of China.

Background: Aged people all over the world are prone to fall down accidentally and be injured with fracture, such as the rib fracture. To protect the elderly, the safety vest has been developed to protect them from being injured when falling down. To effectively protect the elderly, more analysis on the protective capacity of a safety vest under different situation are needed. Read More

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http://dx.doi.org/10.1186/s12938-019-0652-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444614PMC
April 2019
4 Reads

Modified less invasive anterior subcutaneous fixator for unstable Tile-C-pelvic ring fractures: a biomechanical study.

Biomed Eng Online 2019 Mar 29;18(1):38. Epub 2019 Mar 29.

Department of General Trauma & Reconstructive Surgery, University Hospital, LMU Munich, Munich, Germany.

Background: Operative procedures for unstable pelvic ring fractures remain controversially discussed. Minimally invasive treatment options for pelvic ring fractures have several benefits for the patient. But they can also provide disadvantages. Read More

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http://dx.doi.org/10.1186/s12938-019-0648-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441140PMC
March 2019
1 Read

Design, characterization and evaluation of a laser-guided focused ultrasound system for preclinical investigations.

Biomed Eng Online 2019 Mar 28;18(1):36. Epub 2019 Mar 28.

Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD, 21201, USA.

Background: The clinical applications of transcranial focused ultrasound continue to expand and include ablation as well as drug delivery applications in the brain, where treatments are typically guided by MRI. Although MRI-guided focused ultrasound systems are also preferred for many preclinical investigations, they are expensive to purchase and operate, and require the presence of a nearby imaging center. For many basic mechanistic studies, however, MRI is not required. Read More

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http://dx.doi.org/10.1186/s12938-019-0656-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440155PMC

Combining continuous glucose monitoring and insulin pumps to automatically tune the basal insulin infusion in diabetes therapy: a review.

Biomed Eng Online 2019 Mar 29;18(1):37. Epub 2019 Mar 29.

Department of Information Engineering, University of Padova, Via G. Gradenigo 6/B, 35131, Padova, Italy.

For individuals affected by Type 1 diabetes (T1D), a chronic disease in which the pancreas does not produce any insulin, maintaining the blood glucose (BG) concentration as much as possible within the safety range (70-180 mg/dl) allows avoiding short- and long-term complications. The tuning of exogenous insulin infusion can be difficult, especially because of the inter- and intra-day variability of physiological and behavioral factors. Continuous glucose monitoring (CGM) sensors, which monitor glucose concentration in the subcutaneous tissue almost continuously, allowed improving the detection of critical hypo- and hyper-glycemic episodes. Read More

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http://dx.doi.org/10.1186/s12938-019-0658-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440103PMC

Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH): uncertainty quantification of geometric rupture risk parameters.

Biomed Eng Online 2019 Mar 25;18(1):35. Epub 2019 Mar 25.

Department of Fluid Dynamics and Technical Flows, University of Magdeburg, Magdeburg, Germany.

Background: Geometric parameters have been proposed for prediction of cerebral aneurysm rupture risk. Predicting the rupture risk for incidentally detected unruptured aneurysms could help clinicians in their treatment decision. However, assessment of geometric parameters depends on several factors, including the spatial resolution of the imaging modality used and the chosen reconstruction procedure. Read More

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http://dx.doi.org/10.1186/s12938-019-0657-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434802PMC

Multiscale experimental study on the effects of different weight-bearing levels during moderate treadmill exercise on bone quality in growing female rats.

Biomed Eng Online 2019 Mar 22;18(1):33. Epub 2019 Mar 22.

Department of Engineering Mechanics, Jilin University, Changchun, 130022, People's Republic of China.

Background: Bone tissue displays a hierarchical organization. Mechanical environments influence bone mass and structure. This study aimed to explore the effects of different mechanical stimuli on growing bone properties at macro-micro-nano scales. Read More

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http://dx.doi.org/10.1186/s12938-019-0654-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431042PMC
March 2019
1 Read

Analysis of measurement electrode location in bladder urine monitoring using electrical impedance.

Biomed Eng Online 2019 Mar 22;18(1):34. Epub 2019 Mar 22.

Department of Biomedical Engineering, University of Houston, 4849 Calhoun Road, Houston, TX, 77004, USA.

Purpose: The aim of this study was to document more appropriate electrode location of a four-electrode-based electrical impedance technology in the monitoring of bladder filling, and to characterize the relationship between bladder filling duration and the measured electrical impedances.

Methods: A simulation study, based on a 2-dimension computational model, was conducted to determine the preferable locations of excitation and measurement electrodes in a conventional four-electrode setup. A human observation study was subsequently performed on eight healthy volunteers during natural bladder urine accumulation to validate the result of the simulation study. Read More

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http://dx.doi.org/10.1186/s12938-019-0651-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431015PMC

Estimation of continuous elbow joint movement based on human physiological structure.

Biomed Eng Online 2019 Mar 20;18(1):31. Epub 2019 Mar 20.

School of Mechanical Engineering, Hebei University of Technology, Tianjin, 300130, China.

Objective: Human intention recognition technology plays a vital role in the application of robotic exoskeletons and powered exoskeletons. However, the precise estimation of the continuous motion of each joint represents a major challenge. In the current study, we present a method for estimating continuous elbow joint movement. Read More

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http://dx.doi.org/10.1186/s12938-019-0653-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427875PMC

Data driven filtering of bowel sounds using multivariate empirical mode decomposition.

Biomed Eng Online 2019 Mar 20;18(1):28. Epub 2019 Mar 20.

Department of Engineering Cybernetics, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Background: The analysis of abdominal sounds can help to diagnose gastro-intestinal diseases. Sounds originating from the stomach and the intestine, the so-called bowel sounds, occur in various forms. They are described as loose successions or clusters of rather sudden bursts. Read More

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http://dx.doi.org/10.1186/s12938-019-0646-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425713PMC

EZ Entropy: a software application for the entropy analysis of physiological time-series.

Authors:
Peng Li

Biomed Eng Online 2019 Mar 20;18(1):30. Epub 2019 Mar 20.

School of Control Science and Engineering, Shandong University, 17923 Jingshi Road, Jinan, 250061, Shandong, People's Republic of China.

Background: Entropy analysis has been attracting increasing attentions in the recent two or three decades. It assesses complexity, or irregularity, of time-series which is extraordinarily relevant to physiology and diseases as demonstrated by tremendous studies. However, the complexity can hardly be appreciated by traditional methods including time-, frequency-domain analysis, and time-frequency analysis that are the common built-in options in commercialized measurement and statistical software. Read More

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http://dx.doi.org/10.1186/s12938-019-0650-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425722PMC

CNNs for automatic glaucoma assessment using fundus images: an extensive validation.

Biomed Eng Online 2019 Mar 20;18(1):29. Epub 2019 Mar 20.

Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Avenida del Seminario s/n, Moncada, 46313, Valencia, Spain.

Background: Most current algorithms for automatic glaucoma assessment using fundus images rely on handcrafted features based on segmentation, which are affected by the performance of the chosen segmentation method and the extracted features. Among other characteristics, convolutional neural networks (CNNs) are known because of their ability to learn highly discriminative features from raw pixel intensities.

Methods: In this paper, we employed five different ImageNet-trained models (VGG16, VGG19, InceptionV3, ResNet50 and Xception) for automatic glaucoma assessment using fundus images. Read More

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http://dx.doi.org/10.1186/s12938-019-0649-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425593PMC

Correction to: Spasticity assessment based on the Hilbert-Huang transform marginal spectrum entropy and the root mean square of surface electromyography signals: a preliminary study.

Biomed Eng Online 2019 03 20;18(1):32. Epub 2019 Mar 20.

School of Mechanical Engineering, Hefei University of Technology, No. 193 Tunxi Road, Hefei, 230009, China.

After the publication of the original article work [1], it was highlighted that the circuit information and the A/D converter used for acquiring sEMG signal were not correctly reported in the Methods section. The circuit included a 10 Hz high-pass filter instead of 10 Hz notch filter as stated in the original article. The A/D converter was ADS7818, instead of ADS1198 as stated in the original paper. Read More

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http://dx.doi.org/10.1186/s12938-019-0642-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427868PMC
March 2019
1 Read

The relationship between compression garments and electrocardiogram signals during exercise and recovery phase.

Biomed Eng Online 2019 Mar 19;18(1):27. Epub 2019 Mar 19.

Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, VIC, 3122, Australia.

Background: The direction of the current research was to investigate whether electrocardiogram (ECG) signals have been impacted by using compression garments during exercise and recovery phase. Each subject is non-athletes, conducted two running tests, wearing either non-compression garments (NCGs) or compression garments (CGs) throughout experiments and 2-h of the recovery phase. Experiment 1 (number of participants (n) = 8; 61. Read More

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http://dx.doi.org/10.1186/s12938-019-0645-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425647PMC
March 2019
1 Read
1.427 Impact Factor

Differences in gait and trunk movement between patients after ankle fracture and healthy subjects.

Biomed Eng Online 2019 Mar 19;18(1):26. Epub 2019 Mar 19.

Department of Rehabilitation Medicine, Ten-Chan General Hospital, No. 155 Yanping Rd, Zhongli Dist., Taoyuan City, 320, Taiwan.

Background: Studies have shown that gait asymmetry and activity limitation can persist several months or years after ankle fracture. However, evidence of gait and trunk movement patterns following ankle fracture during the early rehabilitation period is scarce. Thus, we compared gait patterns and trunk movement during the early phase of rehabilitation between patients with ankle fracture and matched controls. Read More

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http://dx.doi.org/10.1186/s12938-019-0644-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425625PMC
March 2019
3 Reads

Processing of collagen based biomaterials and the resulting materials properties.

Authors:
Michael Meyer

Biomed Eng Online 2019 Mar 18;18(1):24. Epub 2019 Mar 18.

Research Institute for Leather and Plastic Sheeting, Meissner Ring 1-5, 09599, Freiberg, Germany.

Collagen, the most abundant extracellular matrix protein in animal kingdom belongs to a family of fibrous proteins, which transfer load in tissues and which provide a highly biocompatible environment for cells. This high biocompatibility makes collagen a perfect biomaterial for implantable medical products and scaffolds for in vitro testing systems. To manufacture collagen based solutions, porous sponges, membranes and threads for surgical and dental purposes or cell culture matrices, collagen rich tissues as skin and tendon of mammals are intensively processed by physical and chemical means. Read More

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http://dx.doi.org/10.1186/s12938-019-0647-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423854PMC

Anisotropic non-rigid Iterative Closest Point Algorithm for respiratory motion abdominal surface matching.

Biomed Eng Online 2019 Mar 18;18(1):25. Epub 2019 Mar 18.

Biomedical Engineering, Silesian University of Technology, 40 Roosevelta, 41-800, Zabrze, Poland.

Surface registration is a one of the crucial and actual problems of computer aided surgery. This paper presents the modification of the non-rigid Iterative Closest Point Algorithm which takes into account an anisotropic noise model and landmarks as guided correspondence at the transformation step in every iteration. The presented approach was validated on human abdominal briefing surface data from a time-of-flight camera. Read More

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http://dx.doi.org/10.1186/s12938-019-0643-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423874PMC

Effect of myocardial heterogeneity on ventricular electro-mechanical responses: a computational study.

Biomed Eng Online 2019 Mar 14;18(1):23. Epub 2019 Mar 14.

Department of IT Convergence Engineering, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi, Gyeongbuk, 39253, Republic of Korea.

Background: The heart wall exhibits three layers of different thicknesses: the outer epicardium, mid-myocardium, and inner endocardium. Among these layers, the mid-myocardium is typically the thickest. As indicated by preliminary studies, heart-wall layers exhibit various characteristics with regard to electrophysiology, pharmacology, and pathology. Read More

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http://dx.doi.org/10.1186/s12938-019-0640-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419335PMC
March 2019
1 Read

Image reconstruction utilizing median filtering applied to elastography.

Biomed Eng Online 2019 Mar 12;18(1):22. Epub 2019 Mar 12.

Electrical/Electronic Engineering Department and the Graduate School of Electrical Engineering and Applied Computer Sciences (DAELT-DAELN-CPGEI), Federal University of Technology-Paraná (UTFPR), Curitiba, PR, Brazil.

Background: The resources of ultrafast technology can be used to add another analysis to ultrasound imaging: assessment of tissue viscoelasticity. Ultrafast image formation can be utilized to find transitory shear waves propagating in soft tissue, which permits quantification of the mechanical properties of the tissue via elastography. This technique permits simple and noninvasive diagnosis and monitoring of disease. Read More

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http://dx.doi.org/10.1186/s12938-019-0641-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417019PMC
March 2019
1 Read

Comparing classification techniques for identification of grasped objects.

Biomed Eng Online 2019 Mar 7;18(1):21. Epub 2019 Mar 7.

LAETA-INEGI, Faculty of Engineering, University of Porto, Porto, Portugal.

Background: This work presents a comparison and selection of different machine learning classification techniques applied in the identification of objects using data collected by an instrumented glove during a grasp process. The selected classifiers techniques can be applied to e-rehabilitation and e-training exercises for different pathologies, as in aphasic patients.

Methods: The adopted method uses the data from a commercial instrumented glove. Read More

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http://dx.doi.org/10.1186/s12938-019-0639-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407276PMC

Analyzing temporal dynamics of cell deformation and intracellular movement with video feature aggregation.

Biomed Eng Online 2019 Mar 1;18(1):20. Epub 2019 Mar 1.

Department of Information and Electronics, Beijing Institute of Technology, Beijing, 100081, China.

Background: The research and analysis of cellular physiological properties has been an essential approach to studying some biological and biomedical problems. Temporal dynamics of cells therein are used as a quantifiable indicator of cellular response to extracellular cues and physiological stimuli.

Methods: This work presents a novel image-based framework to profile and model the cell dynamics in live-cell videos. Read More

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http://dx.doi.org/10.1186/s12938-019-0638-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397461PMC
March 2019
4 Reads

Investigating heartbeat-related in-plane motion and stress levels induced at the aortic root.

Biomed Eng Online 2019 Feb 26;18(1):19. Epub 2019 Feb 26.

Laboratoire de Biomécanique Appliquée, Aix-Marseille Université, IFSTTAR, LBA, UMR T24, 51 Bd. P. Dramard, 13015, Marseille, France.

Background: The axial motion of aortic root (AR) due to ventricular traction was previously suggested to contribute to ascending aorta (AA) dissection by increasing its longitudinal stress, but AR in-plane motion effects on stresses have never been studied. The objective is to investigate the contribution of AR in-plane motion to AA stress levels.

Methods: The AR in-plane motion was assessed on magnetic resonance imagining data from 25 healthy volunteers as the movement of the AA section centroid. Read More

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http://dx.doi.org/10.1186/s12938-019-0632-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391796PMC
February 2019
5 Reads

Effects of ultrasound therapy on the synovial fluid proteome in a rabbit surgery-induced model of knee osteoarthritis.

Biomed Eng Online 2019 Feb 22;18(1):18. Epub 2019 Feb 22.

The Fifth Affiliated Hospital of Guangzhou Medicine University, No. 621, GangWan Road, HuangPu District, Guangzhou, 510700, Guangdong Province, China.

Background: Ultrasound (US) therapy may improve osteoarthritis symptoms. We investigated the effects of US on the synovial fluid (SF) proteome in a rabbit knee osteoarthritis (KOA) model to explore its therapeutic mechanisms.

Methods: Sixteen healthy 6-month-old New Zealand white rabbits (eight male, eight female), weighing 2. Read More

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http://dx.doi.org/10.1186/s12938-019-0637-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387552PMC
February 2019
2 Reads

Novel dynamic corneal response parameters in a practice use: a critical review.

Biomed Eng Online 2019 Feb 13;18(1):17. Epub 2019 Feb 13.

Department of Biomedical Computer Systems, Faculty of Computer Science and Materials Science, Institute of Computer Science, University of Silesia, ul. Będzińska 39, 41-200, Sosnowiec, Poland.

Background: Non-contact tonometers based on the method using air puff and Scheimpflug's fast camera are one of the latest devices allowing the measurement of intraocular pressure and additional biomechanical parameters of the cornea. Biomechanical features significantly affect changes in intraocular pressure values, as well as their changes, may indicate the possibility of corneal ectasia. This work presents the latest and already known biomechanical parameters available in the new offered software. Read More

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http://dx.doi.org/10.1186/s12938-019-0636-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375180PMC
February 2019

A pap-smear analysis tool (PAT) for detection of cervical cancer from pap-smear images.

Biomed Eng Online 2019 Feb 12;18(1):16. Epub 2019 Feb 12.

Department of Biomedical Sciences and Engineering, Mbarara University of Science and Technology, Mbarara, 1410, Uganda.

Background: Cervical cancer is preventable if effective screening measures are in place. Pap-smear is the commonest technique used for early screening and diagnosis of cervical cancer. However, the manual analysis of the pap-smears is error prone due to human mistake, moreover, the process is tedious and time-consuming. Read More

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https://biomedical-engineering-online.biomedcentral.com/arti
Publisher Site
http://dx.doi.org/10.1186/s12938-019-0634-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373062PMC
February 2019
1 Read
1.427 Impact Factor

Serial electrocardiography to detect newly emerging or aggravating cardiac pathology: a deep-learning approach.

Biomed Eng Online 2019 Feb 12;18(1):15. Epub 2019 Feb 12.

Cardiology Department, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.

Background: Serial electrocardiography aims to contribute to electrocardiogram (ECG) diagnosis by comparing the ECG under consideration with a previously made ECG in the same individual. Here, we present a novel algorithm to construct dedicated deep-learning neural networks (NNs) that are specialized in detecting newly emerging or aggravating existing cardiac pathology in serial ECGs.

Methods: We developed a novel deep-learning method for serial ECG analysis and tested its performance in detection of heart failure in post-infarction patients, and in the detection of ischemia in patients who underwent elective percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1186/s12938-019-0630-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371549PMC
February 2019

Vision-aided brain-machine interface training system for robotic arm control and clinical application on two patients with cervical spinal cord injury.

Biomed Eng Online 2019 Feb 11;18(1):14. Epub 2019 Feb 11.

Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 03080, South Korea.

Background: While spontaneous robotic arm control using motor imagery has been reported, most previous successful cases have used invasive approaches with advantages in spatial resolution. However, still many researchers continue to investigate methods for robotic arm control with noninvasive neural signal. Most of noninvasive control of robotic arm utilizes P300, steady state visually evoked potential, N2pc, and mental tasks differentiation. Read More

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http://dx.doi.org/10.1186/s12938-019-0633-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371594PMC
February 2019

My Diabetes My Way: supporting online diabetes self-management: progress and analysis from 2016.

Biomed Eng Online 2019 Feb 8;18(1):13. Epub 2019 Feb 8.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.

Background: My Diabetes My Way (MDMW) is the National Health Service (NHS) Scotland website for people with diabetes and their carers. It consists of an interactive information website and an electronic personal health record (ePHR) available to the 291,981 people with diabetes in Scotland. We aimed to analyse the demographic characteristics of current registrants and system usage and activity during 2016. Read More

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http://dx.doi.org/10.1186/s12938-019-0635-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368718PMC
February 2019
1 Read

Partial volume correction for arterial spin labeling using the inherent perfusion information of multiple measurements.

Biomed Eng Online 2019 Feb 4;18(1):12. Epub 2019 Feb 4.

School of Biomedical Engineering, Fourth Military Medical University, Xi'an, China.

Background: Arterial spin labeling (ASL) provides a noninvasive way to measure cerebral blood flow (CBF). The CBF estimation from ASL is heavily contaminated by noise and the partial volume (PV) effect. The multiple measurements of perfusion signals in the ASL sequence are generally acquired and were averaged to suppress the noise. Read More

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http://dx.doi.org/10.1186/s12938-019-0631-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360711PMC
February 2019
1 Read

Docetaxel-loaded human serum albumin (HSA) nanoparticles: synthesis, characterization, and evaluation.

Biomed Eng Online 2019 Jan 31;18(1):11. Epub 2019 Jan 31.

Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, No.2699, Qianjin Street, Changchun, 130012, China.

Background: Docetaxel (DTX) is an anticancer drug that is currently formulated with polysorbate 80 and ethanol (50:50, v/v) in clinical use. Unfortunately, this formulation causes hypersensitivity reactions, leading to severe side-effects, which have been primarily attributed to polysorbate 80.

Methods: In this study, a DTX-loaded human serum albumin (HSA) nanoparticle (DTX-NP) was designed to overcome the hypersensitivity reactions that are induced by polysorbate 80. Read More

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http://dx.doi.org/10.1186/s12938-019-0624-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357434PMC
January 2019
1 Read
1.427 Impact Factor

Finite state machine implementation for left ventricle modeling and control.

Biomed Eng Online 2019 Jan 30;18(1):10. Epub 2019 Jan 30.

Department of Mechanical Engineering, University of Louisiana at Lafayette, 241 E. Lewis St. RM320, Lafayette, LA, 70503, USA.

Background: Simulation of a left ventricle has become a critical facet of evaluating therapies and operations that interact with cardiac performance. The ability to simulate a wide range of possible conditions, changes in cardiac performance, and production of nuisances at transition points enables evaluation of precision medicine concepts that are designed to function through this spectrum. Ventricle models have historically been based on biomechanical analysis, with model architectures constituted of continuous states and not conducive to deterministic processing. Read More

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http://dx.doi.org/10.1186/s12938-019-0628-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354391PMC
January 2019
2 Reads

Potential biomarkers of acute myocardial infarction based on weighted gene co-expression network analysis.

Biomed Eng Online 2019 Jan 25;18(1). Epub 2019 Jan 25.

Shenzhen Yuqiu Biological Big Data Research Institute, Shenzhen, 518033, China.

Background: Acute myocardial infarction (AMI) is the common cause of mortality in developed countries. The feasibility of whole-genome gene expression analysis to identify outcome-related genes and dysregulated pathways remains unknown. Molecular marker such as BNP, CRP and other serum inflammatory markers have got the notice at this point. Read More

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http://dx.doi.org/10.1186/s12938-019-0625-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347746PMC
January 2019
1 Read

Two-stage CNNs for computerized BI-RADS categorization in breast ultrasound images.

Biomed Eng Online 2019 Jan 24;18(1). Epub 2019 Jan 24.

Department of Biomedical Engineering, College of Materials Science and Engineering, Sichuan University, Chengdu, 610065, China.

Background: Quantizing the Breast Imaging Reporting and Data System (BI-RADS) criteria into different categories with the single ultrasound modality has always been a challenge. To achieve this, we proposed a two-stage grading system to automatically evaluate breast tumors from ultrasound images into five categories based on convolutional neural networks (CNNs).

Methods: This new developed automatic grading system was consisted of two stages, including the tumor identification and the tumor grading. Read More

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http://dx.doi.org/10.1186/s12938-019-0626-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346503PMC
January 2019
1.427 Impact Factor

Plane wave imaging combined with eigenspace-based minimum variance beamforming using a ring array in ultrasound computed tomography.

Biomed Eng Online 2019 Jan 23;18(1). Epub 2019 Jan 23.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Background: Ultrasound computed tomography (USCT) is usually realized with a ring array. It can provide better imaging performance and more tissue information by emitting and receiving the ultrasound signal in different directions simultaneously. However, USCT imaging is usually applied with the synthetic aperture (SA) emission method, which leads to a long scanning time with a large number of elements on the ring array. Read More

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http://dx.doi.org/10.1186/s12938-019-0629-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343295PMC
January 2019
10 Reads

Detection of pulmonary ground-glass opacity based on deep learning computer artificial intelligence.

Biomed Eng Online 2019 Jan 22;18(1). Epub 2019 Jan 22.

Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.

Background: A deep learning computer artificial intelligence system is helpful for early identification of ground glass opacities (GGOs).

Methods: Images from the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI) database were used in AlexNet and GoogLeNet to detect pulmonary nodules, and 221 GGO images provided by Xinhua Hospital were used in ResNet50 for detecting GGOs. We used computed tomography image radial reorganization to create the input image of the three-dimensional features, and used the extracted features for deep learning, network training, testing, and analysis. Read More

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http://dx.doi.org/10.1186/s12938-019-0627-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343356PMC
January 2019
2 Reads

Hippocampal subfields segmentation in brain MR images using generative adversarial networks.

Biomed Eng Online 2019 Jan 21;18(1). Epub 2019 Jan 21.

Beijing Institute of Technology, Institute of Signal and Image Processing, School of Information and Electronics, Haidian District, Beijing, 100081, China.

Background: Segmenting the hippocampal subfields accurately from brain magnetic resonance (MR) images is a challenging task in medical image analysis. Due to the small structural size and the morphological complexity of the hippocampal subfields, the traditional segmentation methods are hard to obtain the ideal segmentation result.

Methods: In this paper, we proposed a hippocampal subfields segmentation method using generative adversarial networks. Read More

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http://dx.doi.org/10.1186/s12938-019-0623-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341719PMC
January 2019

Biomechanical analysis of different dynamic sitting techniques: an exploratory study.

Biomed Eng Online 2019 Jan 3;18(1). Epub 2019 Jan 3.

Graduate Institute of Mechatronic System Engineering, National University of Tainan, No. 33, Sec. 2, Shu-Lin St., West Central Dist., Tainan, 70005, Taiwan.

Prolonged static sitting in wheelchairs increases the risk of pressure ulcers. This exploratory study proposed three dynamic sitting techniques in order to reduce the risk of developing pressure ulcer during wheelchair sitting, namely lumbar prominent dynamic sitting, femur upward dynamic sitting, and lumbar prominent with femur upward dynamic sitting. The purpose of this study was to analyze the biomechanical effects of these three techniques on interface pressure. Read More

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http://dx.doi.org/10.1186/s12938-018-0621-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318992PMC
January 2019
1 Read

Myoelectric control algorithm for robot-assisted therapy: a hardware-in-the-loop simulation study.

Biomed Eng Online 2019 Jan 3;18(1). Epub 2019 Jan 3.

Grupo de Automática y Diseño A+D, Cir. 1 #73-76, B22, Medellín, 050031, Colombia.

Background: A direct blow to the knee is one way to injure the anterior cruciate ligament (ACL), e.g., during a football or traffic accident. Read More

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http://dx.doi.org/10.1186/s12938-018-0622-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318920PMC
January 2019
2 Reads

Segmentation of lung parenchyma in CT images using CNN trained with the clustering algorithm generated dataset.

Biomed Eng Online 2019 Jan 3;18(1). Epub 2019 Jan 3.

Sino-Dutch Biomedical and Information Engineering School, Northeastern University, No. 195 Chuangxin Avenue, Hunnan District, Shenyang, 110169, China.

Background: Lung segmentation constitutes a critical procedure for any clinical-decision supporting system aimed to improve the early diagnosis and treatment of lung diseases. Abnormal lungs mainly include lung parenchyma with commonalities on CT images across subjects, diseases and CT scanners, and lung lesions presenting various appearances. Segmentation of lung parenchyma can help locate and analyze the neighboring lesions, but is not well studied in the framework of machine learning. Read More

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Publisher Site
http://dx.doi.org/10.1186/s12938-018-0619-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317251PMC
January 2019
12 Reads

A compact pulsatile simulator based on cam-follower mechanism for generating radial pulse waveforms.

Biomed Eng Online 2019 Jan 3;18(1). Epub 2019 Jan 3.

Future Medicine Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseongdaero, Yuseong-gu, Deajeon, 34054, Republic of Korea.

Background: There exists a growing need for a cost-effective, reliable, and portable pulsation simulator that can generate a wide variety of pulses depending on age and cardiovascular disease. For constructing compact pulsation simulator, this study proposes to use a pneumatic actuator based on cam-follower mechanism controlled by a DC motor. The simulator is intended to generate pulse waveforms for a range of pulse pressures and heart beats that are realistic to human blood pulsations. Read More

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http://dx.doi.org/10.1186/s12938-018-0620-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317228PMC
January 2019
1 Read

In vivo long-term investigation of tumor bearing mKate2 by an in-house fluorescence molecular imaging system.

Biomed Eng Online 2018 Dec 29;17(1):187. Epub 2018 Dec 29.

Department of Biomedical Engineering, College of Engineering, Peking University, No. 5 Yiheyuan Road, Beijing, 100871, China.

Background: Optical imaging is one of the most common, low-cost imaging tools used for investigating the tumor biological behavior in vivo. This study explores the feasibility and sensitivity of a near infrared fluorescent protein mKate2 for a long-term non-invasive tumor imaging in BALB/c nude mice, by using a low-power optical imaging system.

Methods: In this study, breast cancer cell line MDA-MB-435s expressing mKate2 and MDA-MB-231 expressing a dual reporter gene firefly luciferase (fLuc)-GFP were used as cell models. Read More

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Publisher Site
http://dx.doi.org/10.1186/s12938-018-0615-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310933PMC
December 2018
3 Reads
1.427 Impact Factor

Optimal combination of electrodes and conductive gels for brain electrical impedance tomography.

Biomed Eng Online 2018 Dec 20;17(1):186. Epub 2018 Dec 20.

Department of Biomedical Engineering, Fourth Military Medical University, Xi'an, China.

Background: Electrical impedance tomography (EIT) is an emerging imaging technology that has been used to monitor brain injury and detect acute stroke. The time and frequency properties of electrode-skin contact impedance are important for brain EIT because brain EIT measurement is performed over a long period when used to monitor brain injury, and is carried out across a wide range of frequencies when used to detect stroke. To our knowledge, no study has simultaneously investigated the time and frequency properties of both electrode and conductive gel for brain EIT. Read More

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https://biomedical-engineering-online.biomedcentral.com/arti
Publisher Site
http://dx.doi.org/10.1186/s12938-018-0617-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302411PMC
December 2018
13 Reads

A knowledge discovery methodology from EEG data for cyclic alternating pattern detection.

Biomed Eng Online 2018 Dec 18;17(1):185. Epub 2018 Dec 18.

CISUC-Centro de Informática e Sistemas da Universidade de Coimbra, Departamento de Engenharia Informática, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3030-290, Coimbra, Portugal.

Background: Detection and quantification of cyclic alternating patterns (CAP) components has the potential to serve as a disease bio-marker. Few methods exist to discriminate all the different CAP components, they do not present appropriate sensitivities, and often they are evaluated based on accuracy (AC) that is not an appropriate measure for imbalanced datasets.

Methods: We describe a knowledge discovery methodology in data (KDD) aiming the development of automatic CAP scoring approaches. Read More

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https://biomedical-engineering-online.biomedcentral.com/arti
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http://dx.doi.org/10.1186/s12938-018-0616-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299667PMC
December 2018
14 Reads

A refined method of quantifying deceleration capacity index for heart rate variability analysis.

Biomed Eng Online 2018 Dec 18;17(1):184. Epub 2018 Dec 18.

Department of Biomedical Engineering, Chinese PLA General Hospital, Room_105, South Ward Building, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.

Background: Phase-rectified signal averaging (PRSA) was often applied to assess the cardiac vagal modulation. Despite its broad use, this method suffers from the confounding effects of anomalous variants of sinus rhythm. This study aimed to improve the original PRSA method in deceleration capacity (DC) quantification. Read More

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https://biomedical-engineering-online.biomedcentral.com/arti
Publisher Site
http://dx.doi.org/10.1186/s12938-018-0618-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299532PMC
December 2018
9 Reads