1,522 results match your criteria BioMedical Engineering OnLine [Journal]


Novel dynamic corneal response parameters in a practice use: a critical review.

Biomed Eng Online 2019 Feb 13;18(1):17. Epub 2019 Feb 13.

Department of Biomedical Computer Systems, Faculty of Computer Science and Materials Science, Institute of Computer Science, University of Silesia, ul. Będzińska 39, 41-200, Sosnowiec, Poland.

Background: Non-contact tonometers based on the method using air puff and Scheimpflug's fast camera are one of the latest devices allowing the measurement of intraocular pressure and additional biomechanical parameters of the cornea. Biomechanical features significantly affect changes in intraocular pressure values, as well as their changes, may indicate the possibility of corneal ectasia. This work presents the latest and already known biomechanical parameters available in the new offered software. Read More

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http://dx.doi.org/10.1186/s12938-019-0636-3DOI Listing
February 2019

A pap-smear analysis tool (PAT) for detection of cervical cancer from pap-smear images.

Biomed Eng Online 2019 Feb 12;18(1):16. Epub 2019 Feb 12.

Department of Biomedical Sciences and Engineering, Mbarara University of Science and Technology, Mbarara, 1410, Uganda.

Background: Cervical cancer is preventable if effective screening measures are in place. Pap-smear is the commonest technique used for early screening and diagnosis of cervical cancer. However, the manual analysis of the pap-smears is error prone due to human mistake, moreover, the process is tedious and time-consuming. Read More

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http://dx.doi.org/10.1186/s12938-019-0634-5DOI Listing
February 2019
1 Read
1.427 Impact Factor

Serial electrocardiography to detect newly emerging or aggravating cardiac pathology: a deep-learning approach.

Biomed Eng Online 2019 Feb 12;18(1):15. Epub 2019 Feb 12.

Cardiology Department, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.

Background: Serial electrocardiography aims to contribute to electrocardiogram (ECG) diagnosis by comparing the ECG under consideration with a previously made ECG in the same individual. Here, we present a novel algorithm to construct dedicated deep-learning neural networks (NNs) that are specialized in detecting newly emerging or aggravating existing cardiac pathology in serial ECGs.

Methods: We developed a novel deep-learning method for serial ECG analysis and tested its performance in detection of heart failure in post-infarction patients, and in the detection of ischemia in patients who underwent elective percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1186/s12938-019-0630-9DOI Listing
February 2019

Vision-aided brain-machine interface training system for robotic arm control and clinical application on two patients with cervical spinal cord injury.

Biomed Eng Online 2019 Feb 11;18(1):14. Epub 2019 Feb 11.

Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 03080, South Korea.

Background: While spontaneous robotic arm control using motor imagery has been reported, most previous successful cases have used invasive approaches with advantages in spatial resolution. However, still many researchers continue to investigate methods for robotic arm control with noninvasive neural signal. Most of noninvasive control of robotic arm utilizes P300, steady state visually evoked potential, N2pc, and mental tasks differentiation. Read More

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http://dx.doi.org/10.1186/s12938-019-0633-6DOI Listing
February 2019

My Diabetes My Way: supporting online diabetes self-management: progress and analysis from 2016.

Biomed Eng Online 2019 Feb 8;18(1):13. Epub 2019 Feb 8.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.

Background: My Diabetes My Way (MDMW) is the National Health Service (NHS) Scotland website for people with diabetes and their carers. It consists of an interactive information website and an electronic personal health record (ePHR) available to the 291,981 people with diabetes in Scotland. We aimed to analyse the demographic characteristics of current registrants and system usage and activity during 2016. Read More

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http://dx.doi.org/10.1186/s12938-019-0635-4DOI Listing
February 2019

Partial volume correction for arterial spin labeling using the inherent perfusion information of multiple measurements.

Biomed Eng Online 2019 Feb 4;18(1):12. Epub 2019 Feb 4.

School of Biomedical Engineering, Fourth Military Medical University, Xi'an, China.

Background: Arterial spin labeling (ASL) provides a noninvasive way to measure cerebral blood flow (CBF). The CBF estimation from ASL is heavily contaminated by noise and the partial volume (PV) effect. The multiple measurements of perfusion signals in the ASL sequence are generally acquired and were averaged to suppress the noise. Read More

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http://dx.doi.org/10.1186/s12938-019-0631-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360711PMC
February 2019

Docetaxel-loaded human serum albumin (HSA) nanoparticles: synthesis, characterization, and evaluation.

Biomed Eng Online 2019 Jan 31;18(1):11. Epub 2019 Jan 31.

Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, No.2699, Qianjin Street, Changchun, 130012, China.

Background: Docetaxel (DTX) is an anticancer drug that is currently formulated with polysorbate 80 and ethanol (50:50, v/v) in clinical use. Unfortunately, this formulation causes hypersensitivity reactions, leading to severe side-effects, which have been primarily attributed to polysorbate 80.

Methods: In this study, a DTX-loaded human serum albumin (HSA) nanoparticle (DTX-NP) was designed to overcome the hypersensitivity reactions that are induced by polysorbate 80. Read More

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http://dx.doi.org/10.1186/s12938-019-0624-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357434PMC
January 2019
1.427 Impact Factor

Finite state machine implementation for left ventricle modeling and control.

Biomed Eng Online 2019 Jan 30;18(1):10. Epub 2019 Jan 30.

Department of Mechanical Engineering, University of Louisiana at Lafayette, 241 E. Lewis St. RM320, Lafayette, LA, 70503, USA.

Background: Simulation of a left ventricle has become a critical facet of evaluating therapies and operations that interact with cardiac performance. The ability to simulate a wide range of possible conditions, changes in cardiac performance, and production of nuisances at transition points enables evaluation of precision medicine concepts that are designed to function through this spectrum. Ventricle models have historically been based on biomechanical analysis, with model architectures constituted of continuous states and not conducive to deterministic processing. Read More

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http://dx.doi.org/10.1186/s12938-019-0628-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354391PMC
January 2019
1 Read

Potential biomarkers of acute myocardial infarction based on weighted gene co-expression network analysis.

Biomed Eng Online 2019 Jan 25;18(1). Epub 2019 Jan 25.

Shenzhen Yuqiu Biological Big Data Research Institute, Shenzhen, 518033, China.

Background: Acute myocardial infarction (AMI) is the common cause of mortality in developed countries. The feasibility of whole-genome gene expression analysis to identify outcome-related genes and dysregulated pathways remains unknown. Molecular marker such as BNP, CRP and other serum inflammatory markers have got the notice at this point. Read More

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http://dx.doi.org/10.1186/s12938-019-0625-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347746PMC
January 2019

Two-stage CNNs for computerized BI-RADS categorization in breast ultrasound images.

Biomed Eng Online 2019 Jan 24;18(1). Epub 2019 Jan 24.

Department of Biomedical Engineering, College of Materials Science and Engineering, Sichuan University, Chengdu, 610065, China.

Background: Quantizing the Breast Imaging Reporting and Data System (BI-RADS) criteria into different categories with the single ultrasound modality has always been a challenge. To achieve this, we proposed a two-stage grading system to automatically evaluate breast tumors from ultrasound images into five categories based on convolutional neural networks (CNNs).

Methods: This new developed automatic grading system was consisted of two stages, including the tumor identification and the tumor grading. Read More

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http://dx.doi.org/10.1186/s12938-019-0626-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346503PMC
January 2019

Plane wave imaging combined with eigenspace-based minimum variance beamforming using a ring array in ultrasound computed tomography.

Biomed Eng Online 2019 Jan 23;18(1). Epub 2019 Jan 23.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Background: Ultrasound computed tomography (USCT) is usually realized with a ring array. It can provide better imaging performance and more tissue information by emitting and receiving the ultrasound signal in different directions simultaneously. However, USCT imaging is usually applied with the synthetic aperture (SA) emission method, which leads to a long scanning time with a large number of elements on the ring array. Read More

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http://dx.doi.org/10.1186/s12938-019-0629-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343295PMC
January 2019
2 Reads

Detection of pulmonary ground-glass opacity based on deep learning computer artificial intelligence.

Biomed Eng Online 2019 Jan 22;18(1). Epub 2019 Jan 22.

Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.

Background: A deep learning computer artificial intelligence system is helpful for early identification of ground glass opacities (GGOs).

Methods: Images from the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI) database were used in AlexNet and GoogLeNet to detect pulmonary nodules, and 221 GGO images provided by Xinhua Hospital were used in ResNet50 for detecting GGOs. We used computed tomography image radial reorganization to create the input image of the three-dimensional features, and used the extracted features for deep learning, network training, testing, and analysis. Read More

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http://dx.doi.org/10.1186/s12938-019-0627-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343356PMC
January 2019

Hippocampal subfields segmentation in brain MR images using generative adversarial networks.

Biomed Eng Online 2019 Jan 21;18(1). Epub 2019 Jan 21.

Beijing Institute of Technology, Institute of Signal and Image Processing, School of Information and Electronics, Haidian District, Beijing, 100081, China.

Background: Segmenting the hippocampal subfields accurately from brain magnetic resonance (MR) images is a challenging task in medical image analysis. Due to the small structural size and the morphological complexity of the hippocampal subfields, the traditional segmentation methods are hard to obtain the ideal segmentation result.

Methods: In this paper, we proposed a hippocampal subfields segmentation method using generative adversarial networks. Read More

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http://dx.doi.org/10.1186/s12938-019-0623-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341719PMC
January 2019

Biomechanical analysis of different dynamic sitting techniques: an exploratory study.

Biomed Eng Online 2019 Jan 3;18(1). Epub 2019 Jan 3.

Graduate Institute of Mechatronic System Engineering, National University of Tainan, No. 33, Sec. 2, Shu-Lin St., West Central Dist., Tainan, 70005, Taiwan.

Prolonged static sitting in wheelchairs increases the risk of pressure ulcers. This exploratory study proposed three dynamic sitting techniques in order to reduce the risk of developing pressure ulcer during wheelchair sitting, namely lumbar prominent dynamic sitting, femur upward dynamic sitting, and lumbar prominent with femur upward dynamic sitting. The purpose of this study was to analyze the biomechanical effects of these three techniques on interface pressure. Read More

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http://dx.doi.org/10.1186/s12938-018-0621-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318992PMC
January 2019
1 Read

Myoelectric control algorithm for robot-assisted therapy: a hardware-in-the-loop simulation study.

Biomed Eng Online 2019 Jan 3;18(1). Epub 2019 Jan 3.

Grupo de Automática y Diseño A+D, Cir. 1 #73-76, B22, Medellín, 050031, Colombia.

Background: A direct blow to the knee is one way to injure the anterior cruciate ligament (ACL), e.g., during a football or traffic accident. Read More

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http://dx.doi.org/10.1186/s12938-018-0622-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318920PMC
January 2019
2 Reads

Segmentation of lung parenchyma in CT images using CNN trained with the clustering algorithm generated dataset.

Biomed Eng Online 2019 Jan 3;18(1). Epub 2019 Jan 3.

Sino-Dutch Biomedical and Information Engineering School, Northeastern University, No. 195 Chuangxin Avenue, Hunnan District, Shenyang, 110169, China.

Background: Lung segmentation constitutes a critical procedure for any clinical-decision supporting system aimed to improve the early diagnosis and treatment of lung diseases. Abnormal lungs mainly include lung parenchyma with commonalities on CT images across subjects, diseases and CT scanners, and lung lesions presenting various appearances. Segmentation of lung parenchyma can help locate and analyze the neighboring lesions, but is not well studied in the framework of machine learning. Read More

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http://dx.doi.org/10.1186/s12938-018-0619-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317251PMC
January 2019
7 Reads

A compact pulsatile simulator based on cam-follower mechanism for generating radial pulse waveforms.

Biomed Eng Online 2019 Jan 3;18(1). Epub 2019 Jan 3.

Future Medicine Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseongdaero, Yuseong-gu, Deajeon, 34054, Republic of Korea.

Background: There exists a growing need for a cost-effective, reliable, and portable pulsation simulator that can generate a wide variety of pulses depending on age and cardiovascular disease. For constructing compact pulsation simulator, this study proposes to use a pneumatic actuator based on cam-follower mechanism controlled by a DC motor. The simulator is intended to generate pulse waveforms for a range of pulse pressures and heart beats that are realistic to human blood pulsations. Read More

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http://dx.doi.org/10.1186/s12938-018-0620-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317228PMC
January 2019
1 Read

In vivo long-term investigation of tumor bearing mKate2 by an in-house fluorescence molecular imaging system.

Biomed Eng Online 2018 Dec 29;17(1):187. Epub 2018 Dec 29.

Department of Biomedical Engineering, College of Engineering, Peking University, No. 5 Yiheyuan Road, Beijing, 100871, China.

Background: Optical imaging is one of the most common, low-cost imaging tools used for investigating the tumor biological behavior in vivo. This study explores the feasibility and sensitivity of a near infrared fluorescent protein mKate2 for a long-term non-invasive tumor imaging in BALB/c nude mice, by using a low-power optical imaging system.

Methods: In this study, breast cancer cell line MDA-MB-435s expressing mKate2 and MDA-MB-231 expressing a dual reporter gene firefly luciferase (fLuc)-GFP were used as cell models. Read More

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http://dx.doi.org/10.1186/s12938-018-0615-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310933PMC
December 2018
3 Reads
1.427 Impact Factor

Optimal combination of electrodes and conductive gels for brain electrical impedance tomography.

Biomed Eng Online 2018 Dec 20;17(1):186. Epub 2018 Dec 20.

Department of Biomedical Engineering, Fourth Military Medical University, Xi'an, China.

Background: Electrical impedance tomography (EIT) is an emerging imaging technology that has been used to monitor brain injury and detect acute stroke. The time and frequency properties of electrode-skin contact impedance are important for brain EIT because brain EIT measurement is performed over a long period when used to monitor brain injury, and is carried out across a wide range of frequencies when used to detect stroke. To our knowledge, no study has simultaneously investigated the time and frequency properties of both electrode and conductive gel for brain EIT. Read More

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http://dx.doi.org/10.1186/s12938-018-0617-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302411PMC
December 2018
6 Reads

A knowledge discovery methodology from EEG data for cyclic alternating pattern detection.

Biomed Eng Online 2018 Dec 18;17(1):185. Epub 2018 Dec 18.

CISUC-Centro de Informática e Sistemas da Universidade de Coimbra, Departamento de Engenharia Informática, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3030-290, Coimbra, Portugal.

Background: Detection and quantification of cyclic alternating patterns (CAP) components has the potential to serve as a disease bio-marker. Few methods exist to discriminate all the different CAP components, they do not present appropriate sensitivities, and often they are evaluated based on accuracy (AC) that is not an appropriate measure for imbalanced datasets.

Methods: We describe a knowledge discovery methodology in data (KDD) aiming the development of automatic CAP scoring approaches. Read More

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http://dx.doi.org/10.1186/s12938-018-0616-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299667PMC
December 2018
6 Reads

A refined method of quantifying deceleration capacity index for heart rate variability analysis.

Biomed Eng Online 2018 Dec 18;17(1):184. Epub 2018 Dec 18.

Department of Biomedical Engineering, Chinese PLA General Hospital, Room_105, South Ward Building, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.

Background: Phase-rectified signal averaging (PRSA) was often applied to assess the cardiac vagal modulation. Despite its broad use, this method suffers from the confounding effects of anomalous variants of sinus rhythm. This study aimed to improve the original PRSA method in deceleration capacity (DC) quantification. Read More

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http://dx.doi.org/10.1186/s12938-018-0618-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299532PMC
December 2018
6 Reads

Review of cognitive behavioural therapy mobile apps using a reference architecture embedded in the patient-provider relationship.

Biomed Eng Online 2018 Dec 17;17(1):183. Epub 2018 Dec 17.

Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada.

Background: Mobile health apps (mHealth apps) are increasing in popularity and utility for the management of many chronic diseases. Although the current reimbursement structure for mHealth apps is lagging behind the rapidly improving functionality, more clinicians will begin to recommend these apps as they prove their clinical worth. Payors such as the government or private insurance companies will start to reimburse for the use of these technologies, especially if they add value to patients by providing timely support, a more streamlined patient experience, and greater patient convenience. Read More

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http://dx.doi.org/10.1186/s12938-018-0611-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296144PMC
December 2018
1 Read

Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study.

Biomed Eng Online 2018 Dec 5;17(1):182. Epub 2018 Dec 5.

Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Myocardial deformation measured by strain is used to detect electro-mechanical abnormalities in cardiac tissue. Estimation of myocardial properties from regional strain patterns when multiple pathologies are present is therefore a promising application of computer modelling. However, if different tissue properties lead to indistinguishable strain patterns ('degeneracy'), the applicability of any such method will be limited. Read More

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http://dx.doi.org/10.1186/s12938-018-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280493PMC
December 2018
2 Reads

Adaptive filtering of physiological noises in fNIRS data.

Biomed Eng Online 2018 Dec 4;17(1):180. Epub 2018 Dec 4.

School of Mechanical Engineering, Pusan National University, Busan, 46241, Republic of Korea.

The study presents a recursive least-squares estimation method with an exponential forgetting factor for noise removal in functional near-infrared spectroscopy data and extraction of hemodynamic responses (HRs) from the measured data. The HR is modeled as a linear regression form in which the expected HR, the first and second derivatives of the expected HR, a short-separation measurement data, three physiological noises, and the baseline drift are included as components in the regression vector. The proposed method is applied to left-motor-cortex experiments on the right thumb and little finger movements in five healthy male participants. Read More

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http://dx.doi.org/10.1186/s12938-018-0613-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278088PMC
December 2018
1 Read

Imbalanced biomedical data classification using self-adaptive multilayer ELM combined with dynamic GAN.

Biomed Eng Online 2018 Dec 4;17(1):181. Epub 2018 Dec 4.

School of Computer Science and Technology, Medical Imaging Engineering Laboratory, Changchun University of Science and Technology, No.7089, Weixing Road, Changchun, China.

Background: Imbalanced data classification is an inevitable problem in medical intelligent diagnosis. Most of real-world biomedical datasets are usually along with limited samples and high-dimensional feature. This seriously affects the classification performance of the model and causes erroneous guidance for the diagnosis of diseases. Read More

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http://dx.doi.org/10.1186/s12938-018-0604-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280414PMC
December 2018
2 Reads

Computational analysis of the hemodynamic characteristics under interaction influence of β-blocker and LVAD.

Biomed Eng Online 2018 Dec 3;17(1):178. Epub 2018 Dec 3.

Peking University Third Hospital, Peking University Health Science Center, 49 North Garden Rd, Haidian District, Beijing, 100191, China.

Background: Hemodynamic characteristics of the interaction influence among support level and model of LVAD, and coupling β-blocker has not been reported.

Methods: In this study, the effect of support level and model of LVAD on cardiovascular hemodynamic characteristics is investigated. In addition, the effect of β-blocker on unloading with LVAD is analyzed to elucidate the mechanism of LVAD coupling β-blocker. Read More

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http://dx.doi.org/10.1186/s12938-018-0602-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276231PMC
December 2018
1 Read

Evaluation of texture features at staging liver fibrosis based on phase contrast X-ray imaging.

Biomed Eng Online 2018 Dec 3;17(1):179. Epub 2018 Dec 3.

Department of Medical Physics, School of Foundational Education, Peking University Health Science Center, Beijing, 100191, China.

Background: The purpose of this study is to explore the potential of phase contrast imaging to detect fibrotic progress in its early stage; to investigate the feasibility of texture features for quantified diagnosis of liver fibrosis; and to evaluate the performance of back propagation (BP) neural net classifier for characterization and classification of liver fibrosis.

Methods: Fibrous mouse liver samples were imaged by X-ray phase contrast imaging, nine texture measures based on gray-level co-occurrence matrix were calculated and the feasibility of texture features in the characterization and discrimination of liver fibrosis at early stages was investigated. Furthermore, 36 or 18 features were applied to the input of BP classifier; the classification performance was evaluated using receiver operating characteristic curve. Read More

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http://dx.doi.org/10.1186/s12938-018-0612-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276226PMC
December 2018
8 Reads

Effect of hip joint angle at seat-off on hip joint contact force during sit-to-stand movement: a computer simulation study.

Biomed Eng Online 2018 Nov 29;17(1):177. Epub 2018 Nov 29.

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata City, Niigata, 950-3198, Japan.

Background: Sit-to-stand movements are a necessary part of daily life, and excessive mechanical stress on the articular cartilage has been reported to encourage the progression of osteoarthritis. Although a change in hip joint angle at seat-off may affect hip joint contact force during a sit-to-stand movement, the effect is unclear. This study aimed to examine the effect of the hip joint angle at seat-off on the hip joint contact force during a sit-to-stand movement by using a computer simulation. Read More

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http://dx.doi.org/10.1186/s12938-018-0610-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267796PMC
November 2018
2 Reads

High spatial resolution identification of hematoma in inhomogeneous head phantom using broadband fNIR system.

Biomed Eng Online 2018 Nov 27;17(1):176. Epub 2018 Nov 27.

Dept. of ECE, Drexel University, Philadelphia, PA, 19104, USA.

This paper presents a novel method for early detection of hematomas using highly sensitive optical fNIR imaging methods based on broadband photon migration. The NIR experimental measurements of inhomogeneous multi-layer phantoms representing human head are compared to 3D numerical modeling over broadband frequencies of 30-1000 MHz. A finite element method (FEM) simulation of the head phantom are compared to measurements of insertion loss and phase using custom-designed broadband free space optical transmitter (Tx) and receiver (Rx) modules that are developed for photon migration at wavelengths of 670 nm, 795 nm, 850 nm, though results of 670 nm are discussed here. Read More

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http://dx.doi.org/10.1186/s12938-018-0605-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260698PMC
November 2018
1 Read

Metal artifact reduction on cervical CT images by deep residual learning.

Biomed Eng Online 2018 Nov 27;17(1):175. Epub 2018 Nov 27.

School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Background: Cervical cancer is the fifth most common cancer among women, which is the third leading cause of cancer death in women worldwide. Brachytherapy is the most effective treatment for cervical cancer. For brachytherapy, computed tomography (CT) imaging is necessary since it conveys tissue density information which can be used for dose planning. Read More

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http://dx.doi.org/10.1186/s12938-018-0609-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260559PMC
November 2018
16 Reads

Pedobarographic analysis of body weight distribution on the lower limbs and balance after ankle arthrodesis with Ilizarov fixation and internal fixation.

Biomed Eng Online 2018 Nov 26;17(1):174. Epub 2018 Nov 26.

Department of Physiotherapy and Occupational Therapy in Motor Disorders and Dysfunctions, University of Physical Education, Al. IJ Paderewskiego 35, Wroclaw, Poland.

Background: A number of various techniques were proposed to stabilized ankle arthrodesis, among them external and internal fixation. Appropriate balance and adequate distribution of lower limb loads determine normal biomechanics of the locomotor system. We hypothesized that various techniques used to stabilize ankle arthrodesis may exert different effects on (1) balance and (2) distribution of lower limb loads. Read More

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http://dx.doi.org/10.1186/s12938-018-0608-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258158PMC
November 2018
9 Reads

Development of a dental handpiece angle correction device.

Biomed Eng Online 2018 Nov 26;17(1):173. Epub 2018 Nov 26.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 110-768, South Korea.

Background: Preparation of a uniform angle of walls is essential for making an ideal convergence angle in fixed prosthodontics. We developed a de novo detachable angle-correction apparatus for dental handpiece drills that could help the ideal tooth preparation.

Methods: We utilized a gyro sensor to measure the angular velocities to calculate the slope of an object by integrating the values, acceleration sensor to calculate the slope of an object by measuring the acceleration relative to gravity, and Kalman filter algorithm. Read More

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http://dx.doi.org/10.1186/s12938-018-0606-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258456PMC
November 2018
1 Read

Tensile testing of the mechanical behavior of the human periodontal ligament.

Biomed Eng Online 2018 Nov 23;17(1):172. Epub 2018 Nov 23.

Institute of General Mechanics, RWTH-Aachen University, Aachen, Germany.

Background: The periodontal ligament (PDL) plays a key role in alveolar bone remodeling and resorption during tooth movements. The prediction of tooth mobility under functional dental loads requires a deep understanding of the mechanical behavior of the PDL, which is a critical issue in dental biomechanics. This study was aimed to examine the mechanical behavior of the PDL of the maxillary central and lateral incisors from human. Read More

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http://dx.doi.org/10.1186/s12938-018-0607-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251174PMC
November 2018
12 Reads

Salient networks: a novel application to study Alzheimer disease.

Biomed Eng Online 2018 Nov 20;17(Suppl 1):162. Epub 2018 Nov 20.

Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Via Orabona 4, 70123, Bari, Italy.

Background: Extracting fundamental information from data, thus underlining hidden structures or removing noisy information, is one of the most important aims in different scientific fields especially in biological and medical sciences. In this article, we propose an innovative complex network application able to identify salient links for detecting the effect of Alzheimer's disease on brain connectivity. We first build a network model of brain connectivity from structural Magnetic Resonance Imaging (MRI) data, then we study salient networks retrieved from the original ones. Read More

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http://dx.doi.org/10.1186/s12938-018-0566-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245497PMC
November 2018
8 Reads

Blood pressure waveform contour analysis for assessing peripheral resistance changes in sepsis.

Biomed Eng Online 2018 Nov 20;17(1):171. Epub 2018 Nov 20.

Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.

Background: This paper proposes a methodology for helping bridge the gap between the complex waveform information frequently available in an intensive care unit and the simple, lumped values favoured for rapid clinical diagnosis and management. This methodology employs a simple waveform contour analysis approach to compare aortic, femoral and central venous pressure waveforms on a beat-by-beat basis and extract lumped metrics pertaining to the pressure drop and pressure-pulse amplitude attenuation as blood passes through the various sections of systemic circulation.

Results: Validation encompasses a comparison between novel metrics and well-known, analogous clinical metrics such as mean arterial and venous pressures, across an animal model of induced sepsis. Read More

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http://dx.doi.org/10.1186/s12938-018-0603-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245924PMC
November 2018
7 Reads

Machine learning approaches for predicting high cost high need patient expenditures in health care.

Biomed Eng Online 2018 Nov 20;17(Suppl 1):131. Epub 2018 Nov 20.

Department of Computer & Information Science & Engineering, University of Florida, Gainesville, FL, USA.

Background: This paper studies the temporal consistency of health care expenditures in a large state Medicaid program. Predictive machine learning models were used to forecast the expenditures, especially for the high-cost, high-need (HCHN) patients.

Results: We systematically tests temporal correlation of patient-level health care expenditures in both the short and long terms. Read More

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http://dx.doi.org/10.1186/s12938-018-0568-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245495PMC
November 2018
2 Reads

Comprehensive study of instable regions in Pseudomonas aeruginosa and Mycobacterium tuberculosis.

Biomed Eng Online 2018 Nov 20;17(Suppl 1):133. Epub 2018 Nov 20.

Department of Computer Science, City University of Hong Kong, 83 Tat Chee Ave., Hong Kong, People's Republic of China.

Background: Pseudomonas aeruginosa is a common bacterium which is recognized for its association with hospital-acquired infections and its advanced antibiotic resistance mechanisms. Tuberculosis, one of the major causes of mortality, is initiated by the deposition of Mycobacterium tuberculosis. Accessory sequences shared by a subset of strains of a species play an important role in a species' evolution, antibiotic resistance and infectious potential. Read More

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http://dx.doi.org/10.1186/s12938-018-0563-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245595PMC
November 2018
11 Reads

Machine learning in critical care: state-of-the-art and a sepsis case study.

Biomed Eng Online 2018 Nov 20;17(Suppl 1):135. Epub 2018 Nov 20.

Critical Care Deparment, Vall d'Hebron University Hospital. Shock, Organ Dysfunction and Resuscitation (SODIR) Research Group, Vall d' Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, 08035, Barcelona, Spain.

Background: Like other scientific fields, such as cosmology, high-energy physics, or even the life sciences, medicine and healthcare face the challenge of an extremely quick transformation into data-driven sciences. This challenge entails the daunting task of extracting usable knowledge from these data using algorithmic methods. In the medical context this may for instance realized through the design of medical decision support systems for diagnosis, prognosis and patient management. Read More

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http://dx.doi.org/10.1186/s12938-018-0569-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245501PMC
November 2018
2 Reads

Study and characterization of morphogeometric parameters to assist diagnosis of keratoconus.

Biomed Eng Online 2018 Nov 20;17(Suppl 1):161. Epub 2018 Nov 20.

Division of Ophthalmology, Universidad Miguel Hernández, Alicante, Spain.

Background: In case of significant imperfections on the cornea, data acquisition is difficult and a significant level of missing data could require the interpolation of important areas of the cornea, resulting in a very ambiguous model. The development of methods to define in vivo customised geometric properties of the cornea based only on real raw data is extremely useful to diagnose and assess the progression of diseases directly related to the corneal architecture. The present work tries to improve the prognostic of corneal ectasia creating a 3D customised model of the cornea and analysing different geometric variables from this model to determine which variables or combination of them could be defined as an indicator of susceptibility to develop keratoconus. Read More

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http://dx.doi.org/10.1186/s12938-018-0564-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245489PMC
November 2018
9 Reads

Modeling hind-limb kinematics using a bio-inspired algorithm with a local search.

Biomed Eng Online 2018 Nov 20;17(Suppl 1):134. Epub 2018 Nov 20.

Departamento de Ciencias Computacionales, Universidad de Guadalajara, Av.Revolución 1500, Guadalajara, Jalisco, México.

Background: Laboratory rats play a critical role in research because they provide a biological model that can be used for evaluating the affectation of diseases and injuries, and for the evaluation of the effectiveness of new drugs and treatments. The analysis of locomotion in laboratory rats facilitates the understanding of motor defects in many diseases, as well as the damage and recovery after peripheral and central nervous system injuries. However, locomotion analysis of rats remains a great challenge due to the necessity of labor intensive manual annotations of video data required to obtain quantitative measurements of the kinematics of the rodent extremities. Read More

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http://dx.doi.org/10.1186/s12938-018-0565-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245690PMC
November 2018
7 Reads

Human activity monitoring system based on wearable sEMG and accelerometer wireless sensor nodes.

Biomed Eng Online 2018 Nov 20;17(Suppl 1):132. Epub 2018 Nov 20.

DII-Dipartimento di Ingegneria dell'Informazione, Università Politecnica delle Marche, Via Brecce Bianche 12, 60131, Ancona, Italy.

Background: The human activity monitoring technology is one of the most important technologies for ambient assisted living, surveillance-based security, sport and fitness activities, healthcare of elderly people. The activity monitoring is performed in two steps: the acquisition of body signals and the classification of activities being performed. This paper presents a low-cost wearable wireless system specifically designed to acquire surface electromyography (sEMG) and accelerometer signals for monitoring the human activity when performing sport and fitness activities, as well as in healthcare applications. Read More

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http://dx.doi.org/10.1186/s12938-018-0567-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245594PMC
November 2018
1 Read

New remote centre of motion mechanism for robot-assisted minimally invasive surgery.

Biomed Eng Online 2018 Nov 20;17(1):170. Epub 2018 Nov 20.

Harbin Institute of Technology, Nan Gang District, Harbin, China.

Background: Robot-assisted minimally invasive surgery (RMIS) is promising for improving surgical accuracy and dexterity. As the end effector of the robotic arm, the remote centre of motion mechanism is one of the requisite terms for guaranteeing patient safety. The existing remote centre of motion mechanisms are complex and large in volume, as well as high assembly requirement and unsatisfactory precise. Read More

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http://dx.doi.org/10.1186/s12938-018-0601-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245885PMC
November 2018
1 Read

Objective and automatic classification of Parkinson disease with Leap Motion controller.

Biomed Eng Online 2018 Nov 12;17(1):168. Epub 2018 Nov 12.

BioRobotics Institute, Scuola Superiore Sant'Anna, Pontedera, Italy.

Background: The main objective of this paper is to develop and test the ability of the Leap Motion controller (LMC) to assess the motor dysfunction in patients with Parkinson disease (PwPD) based on the MDS-UPDRSIII exercises. Four exercises (thumb forefinger tapping, hand opening/closing, pronation/supination, postural tremor) were used to evaluate the characteristics described in MDS-UPDRSIII. Clinical ratings according to the MDS/UPDRS-section III items were used as target. Read More

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http://dx.doi.org/10.1186/s12938-018-0600-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233603PMC
November 2018
14 Reads

Biomedical engineer's guide to the clinical aspects of intensive care mechanical ventilation.

Biomed Eng Online 2018 Nov 12;17(1):169. Epub 2018 Nov 12.

Centre for Bioengineering, University of Canterbury, Christchurch, New Zealand.

Background: Mechanical ventilation is an essential therapy to support critically ill respiratory failure patients. Current standards of care consist of generalised approaches, such as the use of positive end expiratory pressure to inspired oxygen fraction (PEEP-FiO) tables, which fail to account for the inter- and intra-patient variability between and within patients. The benefits of higher or lower tidal volume, PEEP, and other settings are highly debated and no consensus has been reached. Read More

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http://dx.doi.org/10.1186/s12938-018-0599-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233601PMC
November 2018
14 Reads

Correction to: Semivariogram and Semimadogram functions as descriptors for AMD diagnosis on SD-OCT topographic maps using Support Vector Machine.

Biomed Eng Online 2018 11 8;17(1):167. Epub 2018 Nov 8.

Pontifical Catholic University of Rio de Janeiro PUC-Rio, R. São Vicente, 225 Gávea, Rio de Janeiro, RJ, 22453-900, Brazil.

After publication, it was highlighted that the original publication [1] contained a spelling mistake in the first name of Marcelo Gattas. This was incorrectly captured as Marelo Gattass in the original article which has since been updated. Read More

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http://dx.doi.org/10.1186/s12938-018-0598-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225639PMC
November 2018
1 Read

Automated pipette failure monitoring using image processing for point-of-care testing devices.

Biomed Eng Online 2018 Nov 6;17(Suppl 2):144. Epub 2018 Nov 6.

Department of Convergence Software, Hallym University, Chuncheon, South Korea.

Background: The accuracy and precision of liquid handling can be altered by several causes including wearing or failure of parts, and human error. The last cause is crucial since point-of-care testing (POCT) devices can be used by non-experienced users or patients themselves. Therefore it is important to improve the method of informing the users of POCT device malfunctions due to damage of parts or human error. Read More

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http://dx.doi.org/10.1186/s12938-018-0578-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219047PMC
November 2018
9 Reads

A study of polymerase chain reaction device control via cloud using Firebase Cloud Messaging protocol.

Biomed Eng Online 2018 Nov 6;17(Suppl 2):153. Epub 2018 Nov 6.

Department of Convergence Software, Hallym University, 1, Hallymdaehak-gil, Chuncheon, Republic of Korea.

Background: In this paper, we propose a system for data monitoring and control of polymerase chain reaction (PCR) externally. PCR is a technique for amplifying a desired DNA molecule by repeatedly synthesizing a specific part of DNA sequence. Currently, commercially available systems are standalone systems or operate PCR devices through a computer in the vicinity of devices for control purposes. Read More

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http://dx.doi.org/10.1186/s12938-018-0585-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219053PMC
November 2018
6 Reads

Evaluation-independent system for DNA section amplification.

Biomed Eng Online 2018 Nov 6;17(Suppl 2):150. Epub 2018 Nov 6.

Department of Convergence Software, Hallym University, Chuncheon, South Korea.

Background: In general, the image analysis of nucleic acid for detecting DNA is dependent on the gel documentation system. These experiments may deal with harmful staining agents and are time consuming. To address these issues, real-time polymerase chain reaction (PCR) devices have been developed. Read More

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http://dx.doi.org/10.1186/s12938-018-0580-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219044PMC
November 2018
7 Reads

Performance evaluation of optimal real-time polymerase chain reaction achieved with reduced voltage.

Biomed Eng Online 2018 Nov 6;17(Suppl 2):156. Epub 2018 Nov 6.

Dept. of Convergence Software, Hallym University, Chuncheon, South Korea.

Background: Polymerase chain reaction (PCR) is used in nucleic acid tests of infectious diseases in point-of-care testing. Previous studies have demonstrated real-time PCR that uses a micro-PCR chip made of packing tape, double-sided tape, and a plastic cover with polycarbonate or polypropylene on a black matte printed circuit board substrate. Despite the success of DNA amplification and fluorescence detection using an early version of the micro-PCR chip, reaching the target temperature was fairly slow and, as a result, the total running time was getting longer. Read More

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http://dx.doi.org/10.1186/s12938-018-0579-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218989PMC
November 2018
8 Reads

Permanent magnet actuation for magnetic bead-based DNA extraction.

Biomed Eng Online 2018 Nov 6;17(Suppl 2):143. Epub 2018 Nov 6.

Department of Convergence Software, Hallym University, Chuncheon, South Korea.

Background: Recently, automatic molecular diagnostic devices to extract DNA have been extensively developed using magnetic beads. While various methods can be applied to the control of the beads, the efficiency of the control when incorporated in automatic devices has not been studied. This paper proposes a compact magnet actuation method for the control of magnetic beads for DNA extraction, and compares the efficiency to the already available magnetic bead-based DNA extraction device. Read More

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https://biomedical-engineering-online.biomedcentral.com/arti
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http://dx.doi.org/10.1186/s12938-018-0572-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219032PMC
November 2018
10 Reads