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    1292 results match your criteria BioMedical Engineering OnLine [Journal]

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    Building a resistance to ignition testing device for sunglasses and analysing data: a continuing study for sunglasses standards.
    Biomed Eng Online 2017 Sep 21;16(1):114. Epub 2017 Sep 21.
    Electrical Engineering Department, Engineering School of São Carlos, University of São Paulo, Av. Trabalhador Sãocarlense 400, São Carlos, SP, 13566-590, Brazil.
    Background: Sunglasses popularity skyrocketed since its advent. The ongoing trend led to the creation of standards to protect consumers from injuries and secondary hazards due to spectacles use. In Brazil, the corresponding standard is NBR ISO 12312-1:2015 and since there is no mandatory testing, evaluating sunglasses performance provides an insight into compliance with the standard. Read More

    Area asymmetry of heart rate variability signal.
    Biomed Eng Online 2017 Sep 21;16(1):112. Epub 2017 Sep 21.
    School of Control Science and Engineering, Shandong University, Jinan, 250061, China.
    Background: Heart rate fluctuates beat-by-beat asymmetrically which is known as heart rate asymmetry (HRA). It is challenging to assess HRA robustly based on short-term heartbeat interval series.

    Method: An area index (AI) was developed that combines the distance and phase angle information of points in the Poincaré plot. Read More

    Parameters sensitivity assessment and heat source localization using infrared imaging techniques.
    Biomed Eng Online 2017 Sep 21;16(1):113. Epub 2017 Sep 21.
    Department of Electrical and Computer Engineering, Ryerson University, 350 Victoria St, Toronto, ON, M5B 2K3, Canada.
    Background: At present, infrared (IR) imaging is used both as a non-invasive and a non-ionizing technology. Using an IR camera, it is possible to measure body surface temperature in order to detect tumors and malignant cells. Tumors have a high amount of vasculature and an enhanced metabolism rate, which may result in an increase in body surface temperature by several degrees above its normal level. Read More

    Automatic sleep staging using ear-EEG.
    Biomed Eng Online 2017 Sep 19;16(1):111. Epub 2017 Sep 19.
    Department of Engineering, Aarhus University, Finlandsgade 22, 8200, Aarhus N, Denmark.
    Background: Sleep and sleep quality assessment by means of sleep stage analysis is important for both scientific and clinical applications. Unfortunately, the presently preferred method, polysomnography (PSG), requires considerable expert assistance and significantly affects the sleep of the person under observation. A reliable, accurate and mobile alternative to the PSG would make sleep information much more readily available in a wide range of medical circumstances. Read More

    SinusCor: an advanced tool for heart rate variability analysis.
    Biomed Eng Online 2017 Sep 18;16(1):110. Epub 2017 Sep 18.
    Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Cidade Universitária, Rio de Janeiro, Brazil.
    Background: Heart rate variability (HRV) is a widespread non-invasive technique to assess cardiac autonomic function. Time and frequency domain analyses have been used in HRV studies, and their interpretations are linked with both clinical prognostic and diagnostic information. Statistical and geometrical parameters, Fast Fourier Transform and Autoregressive based periodograms are commonly used approaches for the assessment of stationary RR intervals (RRi) signals. Read More

    Implementation and validation of the extended Hill-type muscle model with robust routing capabilities in LS-DYNA for active human body models.
    Biomed Eng Online 2017 Sep 2;16(1):109. Epub 2017 Sep 2.
    Biomechanics and Biorobotics, Stuttgart Research Centre for Simulation Sciences (SRC SimTech), University of Stuttgart, Allmandring 28, 70569, Stuttgart, Germany.
    Background: In the state of the art finite element AHBMs for car crash analysis in the LS-DYNA software material named *MAT_MUSCLE (*MAT_156) is used for active muscles modeling. It has three elements in parallel configuration, which has several major drawbacks: restraint approximation of the physical reality, complicated parameterization and absence of the integrated activation dynamics. This study presents implementation of the extended four element Hill-type muscle model with serial damping and eccentric force-velocity relation including [Formula: see text] dependent activation dynamics and internal method for physiological muscle routing. Read More

    Evaluation of the effect of different sitting assistive devices in reclining wheelchair on interface pressure.
    Biomed Eng Online 2017 Aug 29;16(1):108. Epub 2017 Aug 29.
    Applied Biomechanics Laboratory, Graduate Institute of Mechatronic System Engineering, National University of Tainan, No. 33, Sec. 2, Shu-Lin St., West Central Dist., Tainan, 70005, Taiwan.
    Background: Reclining wheelchair users often add one or more sitting assistive devices to their wheelchairs, but the effect of these additional sitting assistive devices on the risk of pressure ulcers has rarely been investigated. This study examined the four modes of reclining wheelchair without and with different sitting assistive devices, namely the back reclined mode, the lumbar support with back reclined mode, the femur upward with back reclined mode, and the lumbar support with femur upward with back reclined mode, in terms of their effects on human-wheelchair interface pressure.

    Methods: This study recruited 16 healthy participants to undergo the aforementioned four modes in random order and have their human-wheelchair interface pressure measured. Read More

    Noise-assisted multivariate empirical mode decomposition for multichannel EMG signals.
    Biomed Eng Online 2017 Aug 23;16(1):107. Epub 2017 Aug 23.
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, No. 4, Section 2 of North Jianshe Road, Chengdu, 610054, China.
    Background: Ensemble Empirical Mode Decomposition (EEMD) has been popularised for single-channel Electromyography (EMG) signal processing as it can effectively extract the temporal information of the EMG time series. However, few papers examine the temporal and spatial characteristics across multiple muscle groups in relation to multichannel EMG signals.

    Experiment: The experimental data was obtained from the Center for Machine Learning and Intelligent Systems, University of California Irvine (UCI). Read More

    Evaluation of cervical posture improvement of children with cerebral palsy after physical therapy based on head movements and serious games.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):74. Epub 2017 Aug 18.
    Neural and Cognitive Engineering Group, Centre for Automation and Robotics (CAR) CSIC-UPM, Ctra. Campo Real Km 0.2, 28500, Arganda del Rey, Spain.
    Background: This paper presents the preliminary results of a novel rehabilitation therapy for cervical and trunk control of children with cerebral palsy (CP) based on serious videogames and physical exercise.

    Materials: The therapy is based on the use of the ENLAZA Interface, a head mouse based on inertial technology that will be used to control a set of serious videogames with movements of the head.

    Methods: Ten users with CP participated in the study. Read More

    A protocol for CABS-dock protein-peptide docking driven by side-chain contact information.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):73. Epub 2017 Aug 18.
    Faculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
    Background: The characterization of protein-peptide interactions is a challenge for computational molecular docking. Protein-peptide docking tools face at least two major difficulties: (1) efficient sampling of large-scale conformational changes induced by binding and (2) selection of the best models from a large set of predicted structures. In this paper, we merge an efficient sampling technique with external information about side-chain contacts to sample and select the best possible models. Read More

    Identification of informative features for predicting proinflammatory potentials of engine exhausts.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):66. Epub 2017 Aug 18.
    School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Background: The immunotoxicity of engine exhausts is of high concern to human health due to the increasing prevalence of immune-related diseases. However, the evaluation of immunotoxicity of engine exhausts is currently based on expensive and time-consuming experiments. It is desirable to develop efficient methods for immunotoxicity assessment. Read More

    Automated identification of reference genes based on RNA-seq data.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):65. Epub 2017 Aug 18.
    Departamento de Biología Molecular y Bioquímica, Universidad de Málaga, Malaga, Spain.
    Background: Gene expression analyses demand appropriate reference genes (RGs) for normalization, in order to obtain reliable assessments. Ideally, RG expression levels should remain constant in all cells, tissues or experimental conditions under study. Housekeeping genes traditionally fulfilled this requirement, but they have been reported to be less invariant than expected; therefore, RGs should be tested and validated for every particular situation. Read More

    Modeling EphB4-EphrinB2 protein-protein interaction using flexible docking of a short linear motif.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):71. Epub 2017 Aug 18.
    Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
    Background: Many protein-protein interactions are mediated by a short linear motif. Usually, amino acid sequences of those motifs are known or can be predicted. It is much harder to experimentally characterize or predict their structure in the bound form. Read More

    Feature ranking and rank aggregation for automatic sleep stage classification: a comparative study.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):78. Epub 2017 Aug 18.
    Computational Intelligence Group of CTS/UNINOVA, Caparica, Portugal.
    Background: Nowadays, sleep quality is one of the most important measures of healthy life, especially considering the huge number of sleep-related disorders. Identifying sleep stages using polysomnographic (PSG) signals is the traditional way of assessing sleep quality. However, the manual process of sleep stage classification is time-consuming, subjective and costly. Read More

    Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):72. Epub 2017 Aug 18.
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
    Background: A key challenge in the realm of human disease research is next generation sequencing (NGS) interpretation, whereby identified filtered variant-harboring genes are associated with a patient's disease phenotypes. This necessitates bioinformatics tools linked to comprehensive knowledgebases. The GeneCards suite databases, which include GeneCards (human genes), MalaCards (human diseases) and PathCards (human pathways) together with additional tools, are presented with the focus on MalaCards utility for NGS interpretation as well as for large scale bioinformatic analyses. Read More

    Transcranial direct current stimulation as a motor neurorehabilitation tool: an empirical review.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):76. Epub 2017 Aug 18.
    University of Almería, Almería, Spain.
    The present review collects the most relevant empirical evidence available in the literature until date regarding the effects of transcranial direct current stimulation (tDCS) on the human motor function. tDCS in a non-invasive neurostimulation technique that delivers a weak current through the brain scalp altering the cortical excitability on the target brain area. The electrical current modulates the resting membrane potential of a variety of neuronal population (as pyramidal and gabaergic neurons); raising or dropping the firing rate up or down, depending on the nature of the electrode and the applied intensity. Read More

    Influence of parameter perturbations on the reachability of therapeutic target in systems with switchings.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):77. Epub 2017 Aug 18.
    Silesian University of Technology, Akademicka 16, Gliwice, Poland.
    Background: Examination of physiological processes and the influences of the drugs on them can be efficiently supported by mathematical modeling. One of the biggest problems is related to the exact fitting of the parameters of a model. Conditions inside the organism change dynamically, so the rates of processes are very difficult to estimate. Read More

    Using random forests for assistance in the curation of G-protein coupled receptor databases.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):75. Epub 2017 Aug 18.
    Department of Computer Science, Universitat Politècnica de Catalunya, C. Jordi Girona, 1-3, 08034, Barcelona, Spain.
    Background: Biology is experiencing a gradual but fast transformation from a laboratory-centred science towards a data-centred one. As such, it requires robust data engineering and the use of quantitative data analysis methods as part of database curation. This paper focuses on G protein-coupled receptors, a large and heterogeneous super-family of cell membrane proteins of interest to biology in general. Read More

    Methodological factors affecting joint moments estimation in clinical gait analysis: a systematic review.
    Biomed Eng Online 2017 Aug 18;16(1):106. Epub 2017 Aug 18.
    Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza de Bosis 15, 00135, Rome, Italy.
    Quantitative gait analysis can provide a description of joint kinematics and dynamics, and it is recognized as a clinically useful tool for functional assessment, diagnosis and intervention planning. Clinically interpretable parameters are estimated from quantitative measures (i.e. Read More

    Effect of different inner core diameters on structural strength of cannulated pedicle screws under various lumbar spine movements.
    Biomed Eng Online 2017 Aug 15;16(1):105. Epub 2017 Aug 15.
    Department of Biomedical Engineering, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan.
    Background: Currently, cannulated pedicle screws have been widely used in minimal invasive or navigation techniques. However, the stress distribution and the strength of different core diameters of cannulated screw are not clear. This study aimed to investigate the mechanical strength of cannulated screws with different inner core diameter under various lumbar spine movements using finite element analysis. Read More

    16-Channel biphasic current-mode programmable charge balanced neural stimulation.
    Biomed Eng Online 2017 Aug 14;16(1):104. Epub 2017 Aug 14.
    Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27703, USA.
    Background: Neural stimulation is an important method used to activate or inhibit action potentials of the neuronal anatomical targets found in the brain, central nerve and peripheral nerve. The neural stimulator system produces biphasic pulses that deliver balanced charge into tissue from single or multichannel electrodes. The timing and amplitude of these biphasic pulses are precisely controlled by the neural stimulator software or imbedded algorithms. Read More

    Physiological artifacts in scalp EEG and ear-EEG.
    Biomed Eng Online 2017 Aug 11;16(1):103. Epub 2017 Aug 11.
    Department of Engineering, Aarhus University, Finlandsgade 22, 8200, Aarhus N, Denmark.
    Background: A problem inherent to recording EEG is the interference arising from noise and artifacts. While in a laboratory environment, artifacts and interference can, to a large extent, be avoided or controlled, in real-life scenarios this is a challenge. Ear-EEG is a concept where EEG is acquired from electrodes in the ear. Read More

    Remote monitoring of cardiorespiratory signals from a hovering unmanned aerial vehicle.
    Biomed Eng Online 2017 Aug 8;16(1):101. Epub 2017 Aug 8.
    School of Engineering, University of South Australia, Mawson Lakes, SA, 5095, Australia.
    Background: Remote physiological measurement might be very useful for biomedical diagnostics and monitoring. This study presents an efficient method for remotely measuring heart rate and respiratory rate from video captured by a hovering unmanned aerial vehicle (UVA). The proposed method estimates heart rate and respiratory rate based on the acquired signals obtained from video-photoplethysmography that are synchronous with cardiorespiratory activity. Read More

    Reference-free determination of tissue absorption coefficient by modulation transfer function characterization in spatial frequency domain.
    Biomed Eng Online 2017 Aug 8;16(1):100. Epub 2017 Aug 8.
    College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China.
    Background: Spatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters and therapeutic responses during photodynamic therapy of skin diseases. The conventional SFD measurement requires a reference measurement within the same experimental scenario as that for a test one to calibrate mismatch between the real measurements and the model predictions. Due to the individual physical and geometrical differences among different tissues, organs and patients, an ideal reference measurement might be unavailable in clinical trials. Read More

    Efficacy and safety of a new elastic tourniquet cuff in total knee arthroplasty: a prospective randomized controlled study.
    Biomed Eng Online 2017 Aug 8;16(1):102. Epub 2017 Aug 8.
    Department of Orthopedic Surgery, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.
    Background: The effects of cuff shape, timing of tourniquet application, and automated systems using limb occlusion pressure (LOP) have been reported to minimize the appropriate tourniquet pressure. However, studies on the raw material of the cuff itself to reduce the complications related to the tourniquet have been very rarely reported. The purpose of this study is to report the efficacy and safety of a tourniquet system with a new elastic cuff in which pressure is set with LOP in total knee arthroplasty (TKA). Read More

    Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna.
    Biomed Eng Online 2017 Aug 8;16(1):99. Epub 2017 Aug 8.
    Institute of Medical Equipment, Academy of Military Medical Sciences, Tianjin, China.
    Background: Fatigue damage of the long bones is prevalent in running athletes and military recruits due to vigorous mid- and long-term physical activity. The current study attempted to know the features of bony athletic fatigue damage and to explore the mechanism of fatigue damage repair through bone targeted remodeling process.

    Methods: Right ulnae of the Wistar rats were fatigue loaded on an INSTRON 5865 to construct the athletic fatigue damage model, and several time points (i. Read More

    Damping ratio analysis of tooth stability under various simulated degrees of vertical alveolar bone loss and different root types.
    Biomed Eng Online 2017 Aug 3;16(1):97. Epub 2017 Aug 3.
    School of Dentistry, Taipei Medical University, 250, Wu-Hsing Street, Taipei, Taiwan.
    Background: The purpose of this study was to evaluate the feasibility of using damping ratio (DR) analysis combined with resonance frequency (RF) and periotest (PTV) analyses to provide additional information about natural tooth stability under various simulated degrees of alveolar vertical bone loss and various root types.

    Methods: Three experimental tooth models, including upper central incisor, upper first premolar, and upper first molar were fabricated using Ti6Al4V alloy. In the tooth models, the periodontal ligament and alveolar bone were simulated using a soft lining material and gypsum, respectively. Read More

    Design and implementation of a BSN-based system for plantar health evaluation with exercise load quantification.
    Biomed Eng Online 2017 Aug 3;16(1):98. Epub 2017 Aug 3.
    School of Optoelectronics, Beijing Institute of Technology, Beijing, China.
    Background: Plantar pressure measurement has become increasingly useful in the evaluation of plantar health conditions thanks to the recent progression in sensing technology. Due to the large volume and high energy consumption of monitoring devices, traditional systems for plantar pressure measurement are only focused on static or short-term dynamic monitoring. It makes them inappropriate for early detections of plantar symptoms usually presented in long-term activities. Read More

    In vivo and in vitro performance of a China-made hemodialysis machine: a multi-center prospective controlled study.
    Biomed Eng Online 2017 Aug 2;16(1):96. Epub 2017 Aug 2.
    Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Nephrology, National Clinical Research Center for Chronic Kidney Diseases, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.
    Objective: To evaluate the in vivo and in vitro performance of a China-made dialysis machine (SWS-4000).

    Methods: This was a multi-center prospective controlled study consisting of both long-term in vitro evaluations and cross-over in vivo tests in 132 patients. The China-made SWS-4000 dialysis machine was compared with a German-made dialysis machine (Fresenius 4008) with regard to Kt/V values, URR values, and dialysis-related adverse reactions in patients on maintenance hemodialysis, as well as the ultrafiltration rate, the concentration of electrolytes in the proportioned dialysate, the rate of heparin injection, the flow rate of the blood pump, and the rate of malfunction. Read More

    Non-iterative geometric approach for inverse kinematics of redundant lead-module in a radiosurgical snake-like robot.
    Biomed Eng Online 2017 Aug 1;16(1):93. Epub 2017 Aug 1.
    Research Centre for Medical Robotics and Minimally Invasive Surgical Devices, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
    Background: Snake-like robot is an emerging form of serial-link manipulator with the morphologic design of biological snakes. The redundant robot can be used to assist medical experts in accessing internal organs with minimal or no invasion. Several snake-like robotic designs have been proposed for minimal invasive surgery, however, the few that were developed are yet to be fully explored for clinical procedures. Read More

    Video-tactile pneumatic sensor for soft tissue elastic modulus estimation.
    Biomed Eng Online 2017 Aug 1;16(1):94. Epub 2017 Aug 1.
    Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan.
    Background: A new sensor for estimating elasticity of soft tissues such as a liver was developed for minimally invasive surgery application.

    Methods: By measuring deformation and adjusting internal pressure of the pneumatic sensor head, the sensor can be used to do palpation (indentation) of tissues with wide range of stiffness. A video camera installed within the sensor shell is used to register the radius of the contact area. Read More

    Computational and experimental assessment of influences of hemodynamic shear stress on carotid plaque.
    Biomed Eng Online 2017 Jul 29;16(1):92. Epub 2017 Jul 29.
    Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Ave., Nanshan District, Shenzhen, 518055, People's Republic of China.
    Background: Studies have identified hemodynamic shear stress as an important determinant of endothelial function and atherosclerosis. In this study, we assess the influences of hemodynamic shear stress on carotid plaques.

    Methods: Carotid stenosis phantoms with three severity (30, 50, 70%) were made from 10% polyvinyl alcohol (PVA) cryogel. Read More

    The effects of semantic congruency: a research of audiovisual P300-speller.
    Biomed Eng Online 2017 Jul 25;16(1):91. Epub 2017 Jul 25.
    Department of Biomedical Engineering, Tianjin University, Tianjin, China.
    Background: Over the past few decades, there have been many studies of aspects of brain-computer interface (BCI). Of particular interests are event-related potential (ERP)-based BCI spellers that aim at helping mental typewriting. Nowadays, audiovisual unimodal stimuli based BCI systems have attracted much attention from researchers, and most of the existing studies of audiovisual BCIs were based on semantic incongruent stimuli paradigm. Read More

    Effect of manufacturing and experimental conditions on the mechanical and surface properties of silicone elastomer scaffolds used in endothelial mechanobiological studies.
    Biomed Eng Online 2017 Jul 14;16(1):90. Epub 2017 Jul 14.
    Département de génie mécanique, Université de Sherbrooke, Sherbrooke, QC, J1K 2R1, Canada.
    Background: Mechanobiological studies allow the characterization of cell response to mechanical stresses. Cells need to be supported by a material with properties similar to the physiological environment. Silicone elastomers have been used to produce various in vitro scaffolds of different geometries for endothelial cell studies given its relevant mechanical, optical and surface properties. Read More

    Classification of caesarean section and normal vaginal deliveries using foetal heart rate signals and advanced machine learning algorithms.
    Biomed Eng Online 2017 Jul 6;16(1):89. Epub 2017 Jul 6.
    Concordia Institute for Information Systems Engineering, Concorida University, 1455 de Maisonneuve Blvd West, EV7.632, Montreal, QC, HJ3G 2W1, Canada.
    Background: Visual inspection of cardiotocography traces by obstetricians and midwives is the gold standard for monitoring the wellbeing of the foetus during antenatal care. However, inter- and intra-observer variability is high with only a 30% positive predictive value for the classification of pathological outcomes. This has a significant negative impact on the perinatal foetus and often results in cardio-pulmonary arrest, brain and vital organ damage, cerebral palsy, hearing, visual and cognitive defects and in severe cases, death. Read More

    Investigation of implantable signal transmission characteristics based on visible data of the human leg.
    Biomed Eng Online 2017 Jul 4;16(1):88. Epub 2017 Jul 4.
    State Key Laboratory of Analog and Mixed Signal VLSI, University of Macau, Macau, 999078, China.
    Background: Signal transmission characteristics between implanted medical devices and external equipment has been a common key issue, as has the problem of supplying energy to the devices. It can be used to enable signal transmission from implanted devices that the human body's conductive properties. Using signal transmission by galvanic coupling is one of the most effective signal transmission methods. Read More

    An ultrasound transient elastography system with coded excitation.
    Biomed Eng Online 2017 Jun 28;16(1):87. Epub 2017 Jun 28.
    National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518060, China.
    Background: Ultrasound transient elastography technology has found its place in elastography because it is safe and easy to operate. However, it's application in deep tissue is limited. The aim of this study is to design an ultrasound transient elastography system with coded excitation to obtain greater detection depth. Read More

    Reconstruction of fluorescence molecular tomography with a cosinoidal level set method.
    Biomed Eng Online 2017 Jun 27;16(1):86. Epub 2017 Jun 27.
    Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education & School of Life Science and Technology, Xidian University, Xi'an, 710071, Shaanxi, China.
    Background: Implicit shape-based reconstruction method in fluorescence molecular tomography (FMT) is capable of achieving higher image clarity than image-based reconstruction method. However, the implicit shape method suffers from a low convergence speed and performs unstably due to the utilization of gradient-based optimization methods. Moreover, the implicit shape method requires priori information about the number of targets. Read More

    Lead field theory provides a powerful tool for designing microelectrode array impedance measurements for biological cell detection and observation.
    Biomed Eng Online 2017 Jun 26;16(1):85. Epub 2017 Jun 26.
    Computational Biophysics and Imaging Group, BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Lääkärinkatu 1, 33520, Tampere, Finland.
    Background: Our aim is to introduce a method to enhance the design process of microelectrode array (MEA) based electric bioimpedance measurement systems for improved detection and viability assessment of living cells and tissues. We propose the application of electromagnetic lead field theory and reciprocity for MEA design and measurement result interpretation. Further, we simulated impedance spectroscopy (IS) with two- and four-electrode setups and a biological cell to illustrate the tool in the assessment of the capabilities of given MEA electrode constellations for detecting cells on or in the vicinity of the microelectrodes. Read More

    Anatomic comparison of veins of Labbé between autopsy, digital subtraction angiography and computed tomographic venography.
    Biomed Eng Online 2017 Jun 26;16(1):84. Epub 2017 Jun 26.
    Department of Cardiology, Guangzhou General Hospital of Guangzhou Military Region, PLA, Guangzhou, 510010, China.
    Objective: The drainage portion of the vein of Labbé varies, and it is difficult to predict whether the operation is likely to damage this vein. The aim of this study was to correlate the microanatomy of the vein of Labbé with digital subtraction angiography (DSA) and computed tomographic venography (CTV), in order to provide a basis for the preservation of the vein of Labbé during a supratentorial surgical approach.

    Methods: A total of 30 human cadavers (60 sides) and 61 living patients (110 sides) were examined in this study. Read More

    A vessel length-based method to compute coronary fractional flow reserve from optical coherence tomography images.
    Biomed Eng Online 2017 Jun 26;16(1):83. Epub 2017 Jun 26.
    Department of Mechanical and Biomedical Engineering, Kangwon National University, Kangwondaehak-gil, Chuncheon-si, Kangwon-do, 200-701, Republic of Korea.
    Background: Hemodynamic simulation for quantifying fractional flow reserve (FFR) is often performed in a patient-specific geometry of coronary arteries reconstructed from the images from various imaging modalities. Because optical coherence tomography (OCT) images can provide more precise vascular lumen geometry, regardless of stenotic severity, hemodynamic simulation based on OCT images may be effective. The aim of this study is to perform OCT-FFR simulations by coupling a 3D CFD model from geometrically correct OCT images with a LPM based on vessel lengths extracted from CAG data with clinical validations for the present method. Read More

    Development of stereo endoscope system with its innovative master interface for continuous surgical operation.
    Biomed Eng Online 2017 Jun 24;16(1):81. Epub 2017 Jun 24.
    Institute of Medical and Biological Engineering, Seoul National University, Seoul, 08826, South Korea.
    Background: Although robotic laparoscopic surgery has various benefits when compared with conventional open surgery and minimally invasive surgery, it also has issues to overcome and one of the issues is the discontinuous surgical flow that occurs whenever control is swapped between the endoscope system and the operating robot arm system. This can lead to problems such as collision between surgical instruments, injury to patients, and increased operation time. To achieve continuous surgical operation, a wireless controllable stereo endoscope system is proposed which enables the simultaneous control of the operating robot arm system and the endoscope system. Read More

    A clinical utility assessment of the automatic measurement method of the quality of Meibomian glands.
    Biomed Eng Online 2017 Jun 24;16(1):82. Epub 2017 Jun 24.
    Department of Community Pharmacy, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Katowice, Poland.
    Background: Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics and is the leading cause of evaporative dry eye. Today, diagnostics of MGD is not fully automatic yet and is based on a qualitative assessment made by an ophthalmologist. Therefore, an automatic analysis method was developed to assess MGD quantiatively. Read More

    Multi-purpose ECG telemetry system.
    Biomed Eng Online 2017 Jun 19;16(1):80. Epub 2017 Jun 19.
    Faculty of Electronic Engineering, University of Nis, Aleksandra Medvedeva 14, 18000, Nis, Serbia.
    Background: The Electrocardiogram ECG is one of the most important non-invasive tools for cardiac diseases diagnosis. Taking advantage of the developed telecommunication infrastructure, several approaches that address the development of telemetry cardiac devices were introduced recently. Telemetry ECG devices allow easy and fast ECG monitoring of patients with suspected cardiac issues. Read More

    Estimation of basic reproduction number of the Middle East respiratory syndrome coronavirus (MERS-CoV) during the outbreak in South Korea, 2015.
    Biomed Eng Online 2017 Jun 13;16(1):79. Epub 2017 Jun 13.
    School of Electrical Engineering, Kookmin University, 77 Jeongneung-ro, Seongbuk-gu, 136-702, Seoul, Korea.
    Background: In South Korea, an outbreak of Middle East respiratory syndrome (MERS) occurred in 2015. It was the second largest MERS outbreak. As a result of the outbreak in South Korea, 186 infections were reported, and 36 patients died. Read More

    A composite visualization method for electrophysiology-morphous merging of human heart.
    Biomed Eng Online 2017 Jun 8;16(1):70. Epub 2017 Jun 8.
    School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
    Background: Electrophysiological behavior is of great importance for analyzing the cardiac functional mechanism under cardiac physiological and pathological condition. Due to the complexity of cardiac structure and biophysiological function, visualization of a cardiac electrophysiological model compositively is still a challenge. The lack of either modality of the whole organ structure or cardiac electrophysiological behaviors makes analysis of the intricate mechanisms of cardiac dynamic function a difficult task. Read More

    Thyroid nodule recognition in computed tomography using first order statistics.
    Biomed Eng Online 2017 Jun 2;16(1):67. Epub 2017 Jun 2.
    Radiology Department, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
    Background: Computed tomography (CT) is one of the popular tools for early detection of thyroid nodule. The pixel intensity of thyroid in CT image is very important information to distinguish nodule from normal thyroid tissue. The pixel intensity in normal thyroid tissues is homogeneous and smooth. Read More

    Machine learning techniques for diabetic macular edema (DME) classification on SD-OCT images.
    Biomed Eng Online 2017 Jun 7;16(1):68. Epub 2017 Jun 7.
    LE2I, CNRS, Arts et Métiers, Université Bourgogne Franche-Comté, 12 rue de la Fonderie, Le Creusot, France.
    Background: Spectral domain optical coherence tomography (OCT) (SD-OCT) is most widely imaging equipment used in ophthalmology to detect diabetic macular edema (DME). Indeed, it offers an accurate visualization of the morphology of the retina as well as the retina layers.

    Methods: The dataset used in this study has been acquired by the Singapore Eye Research Institute (SERI), using CIRRUS TM (Carl Zeiss Meditec, Inc. Read More

    Effects of amiodarone on short QT syndrome variant 3 in human ventricles: a simulation study.
    Biomed Eng Online 2017 Jun 7;16(1):69. Epub 2017 Jun 7.
    School of Computer Science and Technology, Harbin Institute of Technology (HIT), Harbin, 150001, China.
    Background: Short QT syndrome (SQTS) is a newly identified clinical disorder associated with atrial and/or ventricular arrhythmias and increased risk of sudden cardiac death (SCD). The SQTS variant 3 is linked to D172N mutation to the KCNJ2 gene that causes a gain-of-function to the inward rectifier potassium channel current (I K1), which shortens the ventricular action potential duration (APD) and effective refractory period (ERP). Pro-arrhythmogenic effects of SQTS have been characterized, but less is known about the possible pharmacological treatment of SQTS. Read More

    Test-retest reliability of mandibular morphology measurements on cone-beam computed tomography-synthesized cephalograms with random head positioning errors.
    Biomed Eng Online 2017 May 30;16(1):62. Epub 2017 May 30.
    Department of Dentistry, School of Dentistry, National Taiwan University Hospital, Taipei, Taiwan, ROC.
    Background: Cephalometric radiography has been used for orthodontic and surgical treatment planning and assessment, and for quantifying mandibular growth. However, it remains unclear how head positioning errors and the level of examiner experience affect the reliability of such morphometric measurements. The current study aimed to bridge the gap by determining the intra-, inter-rater, and inter-session reliability of measurements of mandibular morphology with random head positioning errors as measured by a junior and a senior dentist. Read More

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