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    1309 results match your criteria BioMedical Engineering OnLine [Journal]

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    A customized fixation plate with novel structure designed by topological optimization for mandibular angle fracture based on finite element analysis.
    Biomed Eng Online 2017 Nov 15;16(1):131. Epub 2017 Nov 15.
    Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
    Background: The purpose of this study was to design a customized fixation plate for mandibular angle fracture using topological optimization based on the biomechanical properties of the two conventional fixation systems, and compare the results of stress, strain and displacement distributions calculated by finite element analysis (FEA).

    Methods: A three-dimensional (3D) virtual mandible was reconstructed from CT images with a mimic angle fracture and a 1 mm gap between two bone segments, and then a FEA model, including volume mesh with inhomogeneous bone material properties, three loading conditions and constraints (muscles and condyles), was created to design a customized plate using topological optimization method, then the shape of the plate was referenced from the stress concentrated area on an initial part created from thickened bone surface for optimal calculation, and then the plate was formulated as "V" pattern according to dimensions of standard mini-plate finally. To compare the biomechanical behavior of the "V" plate and other conventional mini-plates for angle fracture fixation, two conventional fixation systems were used: type A, one standard mini-plate, and type B, two standard mini-plates, and the stress, strain and displacement distributions within the three fixation systems were compared and discussed. Read More

    A medium invasiveness multi-level patient's specific template for pedicle screw placement in the scoliosis surgery.
    Biomed Eng Online 2017 Nov 14;16(1):130. Epub 2017 Nov 14.
    Pediatric Neurorehabilitation Research Center, Ergonomics Department, University of Social Welfare and Rehabilitation Sciences (USWR), Tehran, Iran.
    Background: Several methods including free-hand technique, fluoroscopic guidance, image-guided navigation, computer-assisted surgery system, robotic platform and patient's specific templates are being used for pedicle screw placement. These methods have screw misplacements and are not always easy to be applied. Furthermore, it is necessary to expose completely a large portions of the spine in order to access fit entirely around the vertebrae. Read More

    NeoAnalysis: a Python-based toolbox for quick electrophysiological data processing and analysis.
    Biomed Eng Online 2017 Nov 13;16(1):129. Epub 2017 Nov 13.
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.
    Background: In a typical electrophysiological experiment, especially one that includes studying animal behavior, the data collected normally contain spikes, local field potentials, behavioral responses and other associated data. In order to obtain informative results, the data must be analyzed simultaneously with the experimental settings. However, most open-source toolboxes currently available for data analysis were developed to handle only a portion of the data and did not take into account the sorting of experimental conditions. Read More

    Portable wireless neurofeedback system of EEG alpha rhythm enhances memory.
    Biomed Eng Online 2017 Nov 13;16(1):128. Epub 2017 Nov 13.
    Department of Psychology, National Cheng Kung University, Tainan, Taiwan.
    Background: Effect of neurofeedback training (NFT) on enhancement of cognitive function or amelioration of clinical symptoms is inconclusive. The trainability of brain rhythm using a neurofeedback system is uncertainty because various experimental designs are used in previous studies. The current study aimed to develop a portable wireless NFT system for alpha rhythm and to validate effect of the NFT system on memory with a sham-controlled group. Read More

    Hemodynamics analysis of the serial stenotic coronary arteries.
    Biomed Eng Online 2017 Nov 9;16(1):127. Epub 2017 Nov 9.
    Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Ave., Xili University Town, Nanshan, Shenzhen, 518055, Guangdong, China.
    Coronary arterial stenoses, particularly serial stenoses in a single branch, are responsible for complex hemodynamic properties of the coronary arterial trees, and the uncertain prognosis of invasive intervention. Critical information of the blood flow redistribution in the stenotic arterial segments is required for the adequate treatment planning. Therefore, in this study, an image based non-invasive functional assessment is performed to investigate the hemodynamic significances of serial stenoses. Read More

    Empirical study of seven data mining algorithms on different characteristics of datasets for biomedical classification applications.
    Biomed Eng Online 2017 Nov 2;16(1):125. Epub 2017 Nov 2.
    Department of Biomedical Engineering, School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China.
    Background: Various kinds of data mining algorithms are continuously raised with the development of related disciplines. The applicable scopes and their performances of these algorithms are different. Hence, finding a suitable algorithm for a dataset is becoming an important emphasis for biomedical researchers to solve practical problems promptly. Read More

    Prediction of high airway pressure using a non-linear autoregressive model of pulmonary mechanics.
    Biomed Eng Online 2017 Nov 2;16(1):126. Epub 2017 Nov 2.
    Department of Mechanical Engineering, University of Canterbury, Private bag 4800, Christchurch, 8140, New Zealand.
    Background: For mechanically ventilated patients with acute respiratory distress syndrome (ARDS), suboptimal PEEP levels can cause ventilator induced lung injury (VILI). In particular, high PEEP and high peak inspiratory pressures (PIP) can cause over distension of alveoli that is associated with VILI. However, PEEP must also be sufficient to maintain recruitment in ARDS lungs. Read More

    Global Patch Matching (GPM) for freehand 3D ultrasound reconstruction.
    Biomed Eng Online 2017 Oct 30;16(1):124. Epub 2017 Oct 30.
    Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Electronics, Beijing Institute of Technology, Beijing, 100081, China.
    Background: 3D ultrasound volume reconstruction from B-model ultrasound slices can provide more clearly and intuitive structure of tissue and lesion for the clinician.

    Methods: This paper proposes a novel Global Path Matching method for the 3D reconstruction of freehand ultrasound images. The proposed method composes of two main steps: bin-filling scheme and hole-filling strategy. Read More

    Near field effect on elasticity measurement for cartilage-bone structure using Lamb wave method.
    Biomed Eng Online 2017 Oct 30;16(1):123. Epub 2017 Oct 30.
    Orthopaedic Institute, Department of Orthopaedics, the First Affiliated Hospital, Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.
    Background: Cartilage elasticity changes with cartilage degeneration. Hence, cartilage elasticity detection might be an alternative to traditional imaging methods for the early diagnosis of osteoarthritis. Based on the wave propagation measurement, Shear wave elastography (SWE) become an emerging non-invasive elasticity detection method. Read More

    Automatic non-proliferative diabetic retinopathy screening system based on color fundus image.
    Biomed Eng Online 2017 Oct 26;16(1):122. Epub 2017 Oct 26.
    Tianjin Medical University Metabolic Diseases Hospital, Tianjin, 300070, China.
    Background: Non-proliferative diabetic retinopathy is the early stage of diabetic retinopathy. Automatic detection of non-proliferative diabetic retinopathy is significant for clinical diagnosis, early screening and course progression of patients.

    Methods: This paper introduces the design and implementation of an automatic system for screening non-proliferative diabetic retinopathy based on color fundus images. Read More

    Paroxysmal atrial fibrillation recognition based on multi-scale wavelet α-entropy.
    Biomed Eng Online 2017 Oct 23;16(1):121. Epub 2017 Oct 23.
    Department of Biomedical Engineering, Beijing Institute of Technology, Beijing, 100081, China.
    Background: This study proposed an effective method based on the wavelet multi-scale α-entropy features of heart rate variability (HRV) for the recognition of paroxysmal atrial fibrillation (PAF). This new algorithm combines wavelet decomposition and non-linear analysis methods. The PAF signal, the signal distant from PAF, and the normal sinus signals can be identified and distinguished by extracting the characteristic parameters from HRV signals and analyzing their quantification indexes. Read More

    STAMPS: development and verification of swallowing kinematic analysis software.
    Biomed Eng Online 2017 Oct 17;16(1):120. Epub 2017 Oct 17.
    Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
    Background: Swallowing impairment is a common complication in various geriatric and neurodegenerative diseases. Swallowing kinematic analysis is essential to quantitatively evaluate the swallowing motion of the oropharyngeal structures. This study aims to develop a novel swallowing kinematic analysis software, called spatio-temporal analyzer for motion and physiologic study (STAMPS), and verify its validity and reliability. Read More

    Solar UV exposure among outdoor workers in Denmark measured with personal UV-B dosimeters: technical and practical feasibility.
    Biomed Eng Online 2017 Oct 10;16(1):119. Epub 2017 Oct 10.
    The Danish Meteorological Institute, Copenhagen, Denmark.
    Background: Exposure to solar ultraviolet radiation is a well-known cause of skin cancer. This is problematic for outdoor workers. In Denmark alone, occupational skin cancer poses a significant health and safety risk for around 400,000 outdoor workers. Read More

    Low-power transcutaneous current stimulator for wearable applications.
    Biomed Eng Online 2017 Oct 3;16(1):118. Epub 2017 Oct 3.
    The MARCS Institute for Brain, Behaviour and Development, Western Sydney University, Bullecourt Avenue, Milperra, Sydney, Australia.
    Background: Peripheral neuropathic desensitization associated with aging, diabetes, alcoholism and HIV/AIDS, affects tens of millions of people worldwide, and there is little or no treatment available to improve sensory function. Recent studies that apply imperceptible continuous vibration or electrical stimulation have shown promise in improving sensitivity in both diseased and healthy participants. This class of interventions only has an effect during application, necessitating the design of a wearable device for everyday use. Read More

    Diabetic foot ulcer mobile detection system using smart phone thermal camera: a feasibility study.
    Biomed Eng Online 2017 Oct 3;16(1):117. Epub 2017 Oct 3.
    Electrical and Computer Engineering Deparment, Abu Dhabi University, 59911, Abu Dhabi, United Arab Emirates.
    Background: Nowadays, the whole world is being concerned with a major health problem, which is diabetes. A very common symptom of diabetes is the diabetic foot ulcer (DFU). The early detection of such foot complications can protect diabetic patients from any dangerous stages that develop later and may require foot amputation. Read More

    Study of the variations of fall induced hip fracture risk between right and left femurs using CT-based FEA.
    Biomed Eng Online 2017 Oct 3;16(1):116. Epub 2017 Oct 3.
    Department of Mechanical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.
    Background: Hip fracture of elderly people-suffering from osteoporosis-is a severe public health concern, which can be reduced by providing a prior assessment of hip fracture risk. Image-based finite element analysis (FEA) has been considered an effective computational tool to assess the hip fracture risk. Considering the femoral neck region is the weakest, fracture risk indicators (FRI) are evaluated for both single-legged stance and sideways fall configurations and are compared between left and right femurs of each subject. Read More

    Biosignals learning and synthesis using deep neural networks.
    Biomed Eng Online 2017 Sep 25;16(1):115. Epub 2017 Sep 25.
    LIBPhys (Laboratory for Instrumentation, Biomedical Engineering and Radiation Physics), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516, Caparica, Portugal.
    Background: Modeling physiological signals is a complex task both for understanding and synthesize biomedical signals. We propose a deep neural network model that learns and synthesizes biosignals, validated by the morphological equivalence of the original ones. This research could lead the creation of novel algorithms for signal reconstruction in heavily noisy data and source detection in biomedical engineering field. Read More

    Building a resistance to ignition testing device for sunglasses and analysing data: a continuing study for sunglasses standards.
    Biomed Eng Online 2017 Sep 21;16(1):114. Epub 2017 Sep 21.
    Electrical Engineering Department, Engineering School of São Carlos, University of São Paulo, Av. Trabalhador Sãocarlense 400, São Carlos, SP, 13566-590, Brazil.
    Background: Sunglasses popularity skyrocketed since its advent. The ongoing trend led to the creation of standards to protect consumers from injuries and secondary hazards due to spectacles use. In Brazil, the corresponding standard is NBR ISO 12312-1:2015 and since there is no mandatory testing, evaluating sunglasses performance provides an insight into compliance with the standard. Read More

    Area asymmetry of heart rate variability signal.
    Biomed Eng Online 2017 Sep 21;16(1):112. Epub 2017 Sep 21.
    School of Control Science and Engineering, Shandong University, Jinan, 250061, China.
    Background: Heart rate fluctuates beat-by-beat asymmetrically which is known as heart rate asymmetry (HRA). It is challenging to assess HRA robustly based on short-term heartbeat interval series.

    Method: An area index (AI) was developed that combines the distance and phase angle information of points in the Poincaré plot. Read More

    Parameters sensitivity assessment and heat source localization using infrared imaging techniques.
    Biomed Eng Online 2017 Sep 21;16(1):113. Epub 2017 Sep 21.
    Department of Electrical and Computer Engineering, Ryerson University, 350 Victoria St, Toronto, ON, M5B 2K3, Canada.
    Background: At present, infrared (IR) imaging is used both as a non-invasive and a non-ionizing technology. Using an IR camera, it is possible to measure body surface temperature in order to detect tumors and malignant cells. Tumors have a high amount of vasculature and an enhanced metabolism rate, which may result in an increase in body surface temperature by several degrees above its normal level. Read More

    Automatic sleep staging using ear-EEG.
    Biomed Eng Online 2017 Sep 19;16(1):111. Epub 2017 Sep 19.
    Department of Engineering, Aarhus University, Finlandsgade 22, 8200, Aarhus N, Denmark.
    Background: Sleep and sleep quality assessment by means of sleep stage analysis is important for both scientific and clinical applications. Unfortunately, the presently preferred method, polysomnography (PSG), requires considerable expert assistance and significantly affects the sleep of the person under observation. A reliable, accurate and mobile alternative to the PSG would make sleep information much more readily available in a wide range of medical circumstances. Read More

    SinusCor: an advanced tool for heart rate variability analysis.
    Biomed Eng Online 2017 Sep 18;16(1):110. Epub 2017 Sep 18.
    Pulmonary Engineering Laboratory, Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Cidade Universitária, Rio de Janeiro, Brazil.
    Background: Heart rate variability (HRV) is a widespread non-invasive technique to assess cardiac autonomic function. Time and frequency domain analyses have been used in HRV studies, and their interpretations are linked with both clinical prognostic and diagnostic information. Statistical and geometrical parameters, Fast Fourier Transform and Autoregressive based periodograms are commonly used approaches for the assessment of stationary RR intervals (RRi) signals. Read More

    Implementation and validation of the extended Hill-type muscle model with robust routing capabilities in LS-DYNA for active human body models.
    Biomed Eng Online 2017 Sep 2;16(1):109. Epub 2017 Sep 2.
    Biomechanics and Biorobotics, Stuttgart Research Centre for Simulation Sciences (SRC SimTech), University of Stuttgart, Allmandring 28, 70569, Stuttgart, Germany.
    Background: In the state of the art finite element AHBMs for car crash analysis in the LS-DYNA software material named *MAT_MUSCLE (*MAT_156) is used for active muscles modeling. It has three elements in parallel configuration, which has several major drawbacks: restraint approximation of the physical reality, complicated parameterization and absence of the integrated activation dynamics. This study presents implementation of the extended four element Hill-type muscle model with serial damping and eccentric force-velocity relation including [Formula: see text] dependent activation dynamics and internal method for physiological muscle routing. Read More

    Evaluation of the effect of different sitting assistive devices in reclining wheelchair on interface pressure.
    Biomed Eng Online 2017 Aug 29;16(1):108. Epub 2017 Aug 29.
    Applied Biomechanics Laboratory, Graduate Institute of Mechatronic System Engineering, National University of Tainan, No. 33, Sec. 2, Shu-Lin St., West Central Dist., Tainan, 70005, Taiwan.
    Background: Reclining wheelchair users often add one or more sitting assistive devices to their wheelchairs, but the effect of these additional sitting assistive devices on the risk of pressure ulcers has rarely been investigated. This study examined the four modes of reclining wheelchair without and with different sitting assistive devices, namely the back reclined mode, the lumbar support with back reclined mode, the femur upward with back reclined mode, and the lumbar support with femur upward with back reclined mode, in terms of their effects on human-wheelchair interface pressure.

    Methods: This study recruited 16 healthy participants to undergo the aforementioned four modes in random order and have their human-wheelchair interface pressure measured. Read More

    Noise-assisted multivariate empirical mode decomposition for multichannel EMG signals.
    Biomed Eng Online 2017 Aug 23;16(1):107. Epub 2017 Aug 23.
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, No. 4, Section 2 of North Jianshe Road, Chengdu, 610054, China.
    Background: Ensemble Empirical Mode Decomposition (EEMD) has been popularised for single-channel Electromyography (EMG) signal processing as it can effectively extract the temporal information of the EMG time series. However, few papers examine the temporal and spatial characteristics across multiple muscle groups in relation to multichannel EMG signals.

    Experiment: The experimental data was obtained from the Center for Machine Learning and Intelligent Systems, University of California Irvine (UCI). Read More

    Evaluation of cervical posture improvement of children with cerebral palsy after physical therapy based on head movements and serious games.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):74. Epub 2017 Aug 18.
    Neural and Cognitive Engineering Group, Centre for Automation and Robotics (CAR) CSIC-UPM, Ctra. Campo Real Km 0.2, 28500, Arganda del Rey, Spain.
    Background: This paper presents the preliminary results of a novel rehabilitation therapy for cervical and trunk control of children with cerebral palsy (CP) based on serious videogames and physical exercise.

    Materials: The therapy is based on the use of the ENLAZA Interface, a head mouse based on inertial technology that will be used to control a set of serious videogames with movements of the head.

    Methods: Ten users with CP participated in the study. Read More

    A protocol for CABS-dock protein-peptide docking driven by side-chain contact information.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):73. Epub 2017 Aug 18.
    Faculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
    Background: The characterization of protein-peptide interactions is a challenge for computational molecular docking. Protein-peptide docking tools face at least two major difficulties: (1) efficient sampling of large-scale conformational changes induced by binding and (2) selection of the best models from a large set of predicted structures. In this paper, we merge an efficient sampling technique with external information about side-chain contacts to sample and select the best possible models. Read More

    Identification of informative features for predicting proinflammatory potentials of engine exhausts.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):66. Epub 2017 Aug 18.
    School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Background: The immunotoxicity of engine exhausts is of high concern to human health due to the increasing prevalence of immune-related diseases. However, the evaluation of immunotoxicity of engine exhausts is currently based on expensive and time-consuming experiments. It is desirable to develop efficient methods for immunotoxicity assessment. Read More

    Automated identification of reference genes based on RNA-seq data.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):65. Epub 2017 Aug 18.
    Departamento de Biología Molecular y Bioquímica, Universidad de Málaga, Malaga, Spain.
    Background: Gene expression analyses demand appropriate reference genes (RGs) for normalization, in order to obtain reliable assessments. Ideally, RG expression levels should remain constant in all cells, tissues or experimental conditions under study. Housekeeping genes traditionally fulfilled this requirement, but they have been reported to be less invariant than expected; therefore, RGs should be tested and validated for every particular situation. Read More

    Modeling EphB4-EphrinB2 protein-protein interaction using flexible docking of a short linear motif.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):71. Epub 2017 Aug 18.
    Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland.
    Background: Many protein-protein interactions are mediated by a short linear motif. Usually, amino acid sequences of those motifs are known or can be predicted. It is much harder to experimentally characterize or predict their structure in the bound form. Read More

    Feature ranking and rank aggregation for automatic sleep stage classification: a comparative study.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):78. Epub 2017 Aug 18.
    Computational Intelligence Group of CTS/UNINOVA, Caparica, Portugal.
    Background: Nowadays, sleep quality is one of the most important measures of healthy life, especially considering the huge number of sleep-related disorders. Identifying sleep stages using polysomnographic (PSG) signals is the traditional way of assessing sleep quality. However, the manual process of sleep stage classification is time-consuming, subjective and costly. Read More

    Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):72. Epub 2017 Aug 18.
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
    Background: A key challenge in the realm of human disease research is next generation sequencing (NGS) interpretation, whereby identified filtered variant-harboring genes are associated with a patient's disease phenotypes. This necessitates bioinformatics tools linked to comprehensive knowledgebases. The GeneCards suite databases, which include GeneCards (human genes), MalaCards (human diseases) and PathCards (human pathways) together with additional tools, are presented with the focus on MalaCards utility for NGS interpretation as well as for large scale bioinformatic analyses. Read More

    Transcranial direct current stimulation as a motor neurorehabilitation tool: an empirical review.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):76. Epub 2017 Aug 18.
    University of Almería, Almería, Spain.
    The present review collects the most relevant empirical evidence available in the literature until date regarding the effects of transcranial direct current stimulation (tDCS) on the human motor function. tDCS in a non-invasive neurostimulation technique that delivers a weak current through the brain scalp altering the cortical excitability on the target brain area. The electrical current modulates the resting membrane potential of a variety of neuronal population (as pyramidal and gabaergic neurons); raising or dropping the firing rate up or down, depending on the nature of the electrode and the applied intensity. Read More

    Influence of parameter perturbations on the reachability of therapeutic target in systems with switchings.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):77. Epub 2017 Aug 18.
    Silesian University of Technology, Akademicka 16, Gliwice, Poland.
    Background: Examination of physiological processes and the influences of the drugs on them can be efficiently supported by mathematical modeling. One of the biggest problems is related to the exact fitting of the parameters of a model. Conditions inside the organism change dynamically, so the rates of processes are very difficult to estimate. Read More

    Using random forests for assistance in the curation of G-protein coupled receptor databases.
    Biomed Eng Online 2017 Aug 18;16(Suppl 1):75. Epub 2017 Aug 18.
    Department of Computer Science, Universitat Politècnica de Catalunya, C. Jordi Girona, 1-3, 08034, Barcelona, Spain.
    Background: Biology is experiencing a gradual but fast transformation from a laboratory-centred science towards a data-centred one. As such, it requires robust data engineering and the use of quantitative data analysis methods as part of database curation. This paper focuses on G protein-coupled receptors, a large and heterogeneous super-family of cell membrane proteins of interest to biology in general. Read More

    Methodological factors affecting joint moments estimation in clinical gait analysis: a systematic review.
    Biomed Eng Online 2017 Aug 18;16(1):106. Epub 2017 Aug 18.
    Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza de Bosis 15, 00135, Rome, Italy.
    Quantitative gait analysis can provide a description of joint kinematics and dynamics, and it is recognized as a clinically useful tool for functional assessment, diagnosis and intervention planning. Clinically interpretable parameters are estimated from quantitative measures (i.e. Read More

    Effect of different inner core diameters on structural strength of cannulated pedicle screws under various lumbar spine movements.
    Biomed Eng Online 2017 Aug 15;16(1):105. Epub 2017 Aug 15.
    Department of Biomedical Engineering, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan.
    Background: Currently, cannulated pedicle screws have been widely used in minimal invasive or navigation techniques. However, the stress distribution and the strength of different core diameters of cannulated screw are not clear. This study aimed to investigate the mechanical strength of cannulated screws with different inner core diameter under various lumbar spine movements using finite element analysis. Read More

    16-Channel biphasic current-mode programmable charge balanced neural stimulation.
    Biomed Eng Online 2017 Aug 14;16(1):104. Epub 2017 Aug 14.
    Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27703, USA.
    Background: Neural stimulation is an important method used to activate or inhibit action potentials of the neuronal anatomical targets found in the brain, central nerve and peripheral nerve. The neural stimulator system produces biphasic pulses that deliver balanced charge into tissue from single or multichannel electrodes. The timing and amplitude of these biphasic pulses are precisely controlled by the neural stimulator software or imbedded algorithms. Read More

    Physiological artifacts in scalp EEG and ear-EEG.
    Biomed Eng Online 2017 Aug 11;16(1):103. Epub 2017 Aug 11.
    Department of Engineering, Aarhus University, Finlandsgade 22, 8200, Aarhus N, Denmark.
    Background: A problem inherent to recording EEG is the interference arising from noise and artifacts. While in a laboratory environment, artifacts and interference can, to a large extent, be avoided or controlled, in real-life scenarios this is a challenge. Ear-EEG is a concept where EEG is acquired from electrodes in the ear. Read More

    Remote monitoring of cardiorespiratory signals from a hovering unmanned aerial vehicle.
    Biomed Eng Online 2017 Aug 8;16(1):101. Epub 2017 Aug 8.
    School of Engineering, University of South Australia, Mawson Lakes, SA, 5095, Australia.
    Background: Remote physiological measurement might be very useful for biomedical diagnostics and monitoring. This study presents an efficient method for remotely measuring heart rate and respiratory rate from video captured by a hovering unmanned aerial vehicle (UVA). The proposed method estimates heart rate and respiratory rate based on the acquired signals obtained from video-photoplethysmography that are synchronous with cardiorespiratory activity. Read More

    Reference-free determination of tissue absorption coefficient by modulation transfer function characterization in spatial frequency domain.
    Biomed Eng Online 2017 Aug 8;16(1):100. Epub 2017 Aug 8.
    College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China.
    Background: Spatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters and therapeutic responses during photodynamic therapy of skin diseases. The conventional SFD measurement requires a reference measurement within the same experimental scenario as that for a test one to calibrate mismatch between the real measurements and the model predictions. Due to the individual physical and geometrical differences among different tissues, organs and patients, an ideal reference measurement might be unavailable in clinical trials. Read More

    Efficacy and safety of a new elastic tourniquet cuff in total knee arthroplasty: a prospective randomized controlled study.
    Biomed Eng Online 2017 Aug 8;16(1):102. Epub 2017 Aug 8.
    Department of Orthopedic Surgery, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, South Korea.
    Background: The effects of cuff shape, timing of tourniquet application, and automated systems using limb occlusion pressure (LOP) have been reported to minimize the appropriate tourniquet pressure. However, studies on the raw material of the cuff itself to reduce the complications related to the tourniquet have been very rarely reported. The purpose of this study is to report the efficacy and safety of a tourniquet system with a new elastic cuff in which pressure is set with LOP in total knee arthroplasty (TKA). Read More

    Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna.
    Biomed Eng Online 2017 Aug 8;16(1):99. Epub 2017 Aug 8.
    Institute of Medical Equipment, Academy of Military Medical Sciences, Tianjin, China.
    Background: Fatigue damage of the long bones is prevalent in running athletes and military recruits due to vigorous mid- and long-term physical activity. The current study attempted to know the features of bony athletic fatigue damage and to explore the mechanism of fatigue damage repair through bone targeted remodeling process.

    Methods: Right ulnae of the Wistar rats were fatigue loaded on an INSTRON 5865 to construct the athletic fatigue damage model, and several time points (i. Read More

    Damping ratio analysis of tooth stability under various simulated degrees of vertical alveolar bone loss and different root types.
    Biomed Eng Online 2017 Aug 3;16(1):97. Epub 2017 Aug 3.
    School of Dentistry, Taipei Medical University, 250, Wu-Hsing Street, Taipei, Taiwan.
    Background: The purpose of this study was to evaluate the feasibility of using damping ratio (DR) analysis combined with resonance frequency (RF) and periotest (PTV) analyses to provide additional information about natural tooth stability under various simulated degrees of alveolar vertical bone loss and various root types.

    Methods: Three experimental tooth models, including upper central incisor, upper first premolar, and upper first molar were fabricated using Ti6Al4V alloy. In the tooth models, the periodontal ligament and alveolar bone were simulated using a soft lining material and gypsum, respectively. Read More

    Design and implementation of a BSN-based system for plantar health evaluation with exercise load quantification.
    Biomed Eng Online 2017 Aug 3;16(1):98. Epub 2017 Aug 3.
    School of Optoelectronics, Beijing Institute of Technology, Beijing, China.
    Background: Plantar pressure measurement has become increasingly useful in the evaluation of plantar health conditions thanks to the recent progression in sensing technology. Due to the large volume and high energy consumption of monitoring devices, traditional systems for plantar pressure measurement are only focused on static or short-term dynamic monitoring. It makes them inappropriate for early detections of plantar symptoms usually presented in long-term activities. Read More

    In vivo and in vitro performance of a China-made hemodialysis machine: a multi-center prospective controlled study.
    Biomed Eng Online 2017 Aug 2;16(1):96. Epub 2017 Aug 2.
    Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Nephrology, National Clinical Research Center for Chronic Kidney Diseases, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.
    Objective: To evaluate the in vivo and in vitro performance of a China-made dialysis machine (SWS-4000).

    Methods: This was a multi-center prospective controlled study consisting of both long-term in vitro evaluations and cross-over in vivo tests in 132 patients. The China-made SWS-4000 dialysis machine was compared with a German-made dialysis machine (Fresenius 4008) with regard to Kt/V values, URR values, and dialysis-related adverse reactions in patients on maintenance hemodialysis, as well as the ultrafiltration rate, the concentration of electrolytes in the proportioned dialysate, the rate of heparin injection, the flow rate of the blood pump, and the rate of malfunction. Read More

    Non-iterative geometric approach for inverse kinematics of redundant lead-module in a radiosurgical snake-like robot.
    Biomed Eng Online 2017 Aug 1;16(1):93. Epub 2017 Aug 1.
    Research Centre for Medical Robotics and Minimally Invasive Surgical Devices, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
    Background: Snake-like robot is an emerging form of serial-link manipulator with the morphologic design of biological snakes. The redundant robot can be used to assist medical experts in accessing internal organs with minimal or no invasion. Several snake-like robotic designs have been proposed for minimal invasive surgery, however, the few that were developed are yet to be fully explored for clinical procedures. Read More

    Video-tactile pneumatic sensor for soft tissue elastic modulus estimation.
    Biomed Eng Online 2017 Aug 1;16(1):94. Epub 2017 Aug 1.
    Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan.
    Background: A new sensor for estimating elasticity of soft tissues such as a liver was developed for minimally invasive surgery application.

    Methods: By measuring deformation and adjusting internal pressure of the pneumatic sensor head, the sensor can be used to do palpation (indentation) of tissues with wide range of stiffness. A video camera installed within the sensor shell is used to register the radius of the contact area. Read More

    Computational and experimental assessment of influences of hemodynamic shear stress on carotid plaque.
    Biomed Eng Online 2017 Jul 29;16(1):92. Epub 2017 Jul 29.
    Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Ave., Nanshan District, Shenzhen, 518055, People's Republic of China.
    Background: Studies have identified hemodynamic shear stress as an important determinant of endothelial function and atherosclerosis. In this study, we assess the influences of hemodynamic shear stress on carotid plaques.

    Methods: Carotid stenosis phantoms with three severity (30, 50, 70%) were made from 10% polyvinyl alcohol (PVA) cryogel. Read More

    The effects of semantic congruency: a research of audiovisual P300-speller.
    Biomed Eng Online 2017 Jul 25;16(1):91. Epub 2017 Jul 25.
    Department of Biomedical Engineering, Tianjin University, Tianjin, China.
    Background: Over the past few decades, there have been many studies of aspects of brain-computer interface (BCI). Of particular interests are event-related potential (ERP)-based BCI spellers that aim at helping mental typewriting. Nowadays, audiovisual unimodal stimuli based BCI systems have attracted much attention from researchers, and most of the existing studies of audiovisual BCIs were based on semantic incongruent stimuli paradigm. Read More

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