17,963 results match your criteria BioMed research international[Journal]


The Mechanism of Zinc Sulfate in Improving Fertility in Obese Rats Analyzed by Sperm Proteomic Analysis.

Biomed Res Int 2020 4;2020:9876363. Epub 2020 May 4.

NHC Key Laboratory of Family Planning and Healthy, Hebei Key Laboratory of Reproductive Medicine, Hebei Research Institute for Family Planning Science and Technology, Shijiazhuang 050071, China.

This study investigates the mechanism underlying the improving effect of zinc on fertility in obese rats using proteomics. The effects of three different doses of ZnSO on spermatogenesis and hormone levels were studied. Testicular spermatogenesis was observed by HE staining. Read More

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http://dx.doi.org/10.1155/2020/9876363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222545PMC

Abnormal Levels of Liver Enzymes and Hepatotoxicity in HIV-Positive, TB, and HIV/TB-Coinfected Patients on Treatment in Fako Division, Southwest Region of Cameroon.

Biomed Res Int 2020 12;2020:9631731. Epub 2020 May 12.

Infectious Disease Laboratory, Faculty of Health Sciences, University of Buea, P.O. Box 63, Buea, Cameroon.

Hepatotoxicity is historically the 3 most common reason for drug withdrawal and toxicity-related discontinuation of treatment. This study was aimed at determining the incidence and the onset of hepatotoxicity and at evaluating the relationship of some risk factors for hepatotoxicity among Human Immunodeficiency Virus- (HIV-) positive, tuberculosis (TB), and HIV/TB patients on treatment. This was a prospective follow-up study involving 125 participants from the HIV/AIDS and TB treatment centres in three hospitals in Fako Division of Cameroon. Read More

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http://dx.doi.org/10.1155/2020/9631731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243024PMC

LncRNA HOTAIR Contributes to Sorafenib Resistance through Suppressing miR-217 in Hepatic Carcinoma.

Biomed Res Int 2020 9;2020:9515071. Epub 2020 May 9.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.

Background: Sorafenib is a multi-target kinase inhibitor that has been approved as a unique target drug for the treatment of advanced hepatocellular carcinoma (HCC). However, due to the frequent occurrence of drug resistance, its treatment efficacy is often limited. The aim of this study was to explore the function of HOX transcript antisense intergenic RNA (HOTAIR) for the treatment of HCC with sorafenib, and its underlying mechanism. Read More

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http://dx.doi.org/10.1155/2020/9515071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232684PMC

Effects of Cardiac Sympathetic Neurodegeneration and PPAR Activation on Rhesus Macaque Whole Blood miRNA and mRNA Expression Profiles.

Biomed Res Int 2020 2;2020:9426204. Epub 2020 May 2.

Preclinical Parkinson's Research Program, Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, 53706 WI, USA.

Degeneration of sympathetic innervation of the heart occurs in numerous diseases, including diabetes, idiopathic REM sleep disorder, and Parkinson's disease (PD). In PD, cardiac sympathetic denervation occurs in 80-90% of patients and can begin before the onset of motor symptoms. Today, there are no disease-modifying therapies for cardiac sympathetic neurodegeneration, and biomarkers are limited to radioimaging techniques. Read More

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http://dx.doi.org/10.1155/2020/9426204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212295PMC

Clinical and Genetic Analyses of 38 Chinese Patients with Peutz-Jeghers Syndrome.

Biomed Res Int 2020 11;2020:9159315. Epub 2020 May 11.

Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Background: Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disease caused by a germline mutation in the gene. It is characterized by mucocutaneous pigmentation, gastrointestinal hamartomatous polyps, and cancer predisposition.

Aims: We aimed to summarize the main clinical and genetic features of Chinese PJS patients and assessed the genotype-phenotype correlations. Read More

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http://dx.doi.org/10.1155/2020/9159315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240661PMC

Effects of Statins on Lipid Profile of Kidney Transplant Recipients: A Meta-Analysis of Randomized Controlled Trials.

Biomed Res Int 2020 2;2020:9094543. Epub 2020 May 2.

Department of Nephrology, The First Hospital of Jilin University, Changchun 130000, China.

Objective: To assess the benefits of statins on lipid profile in kidney transplant recipients via a meta-analysis.

Methods: We systematically identified peer-reviewed clinical trials, review articles, and treatment guidelines from PubMed, Embase, the Cochrane Library, Wanfang, Chinese National Knowledge Infrastructure (CNKI), SinoMed (CBM), and Chongqing VIP databases from inception to April 2019. In the analysis, only randomized controlled clinical trials performed in human were included. Read More

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http://dx.doi.org/10.1155/2020/9094543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212277PMC

Challenges in Cancer Biomarker Discovery Exemplified by the Identification of Diagnostic MicroRNAs in Prostate Tissues.

Biomed Res Int 2020 5;2020:9086829. Epub 2020 May 5.

Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Identification and clinical translation of routinely tested biomarkers require a complex and multistep workflow. Here, we described a confirmatory process estimating the utility of previously identified candidate tissue miRNAs for diagnosis of prostate cancer (PCa). RNA was isolated from formalin-fixed paraffin-embedded (FFPE) prostate tissue surgically resected from 44 patients with PCa and 24 patients with benign prostate hyperplasia (BPH). Read More

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http://dx.doi.org/10.1155/2020/9086829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225851PMC

Differentiation of Pelvic Osteosarcoma and Ewing Sarcoma Using Radiomic Analysis Based on T2-Weighted Images and Contrast-Enhanced T1-Weighted Images.

Biomed Res Int 2020 11;2020:9078603. Epub 2020 May 11.

Department of Radiology, Peking University People's Hospital, Beijing, China 100044.

Objective: To determine if osteosarcoma (OS) and Ewing sarcoma (EWS) of the pelvis based on MRI can be differentiated using radiomic analysis.

Materials And Methods: In this study, 3.0 T magnetic resonance (MR) data of 66 patients (40 males and 26 females, mean age 27. Read More

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http://dx.doi.org/10.1155/2020/9078603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240794PMC

Long Noncoding RNA Serve as a Potential Predictive Biomarker for Breast Cancer: A Meta-Analysis.

Biomed Res Int 2020 10;2020:9045786. Epub 2020 May 10.

College of Traditional Chinese Medicine of Jinan University, Guangzhou, China.

Purpose: The detection of long noncoding RNA (lncRNA) is a novel method for breast cancer diagnosis. The purpose of this meta-analysis was to evaluate the clinical significance of lncRNAs in identification of human breast cancer.

Methods: Electronic databases, including PubMed (176), EMBASE (167), Cochrane Library (4), Web of Science (273), CNKI (41), VIP (18), and wanfang (21), were searched for relevant original articles. Read More

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http://dx.doi.org/10.1155/2020/9045786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238389PMC

Two Time Point Analysis of the Change in Risk and Aging Factors for Major Cancers: A 10-Year Longitudinal Study in China.

Authors:
Liu Hui

Biomed Res Int 2020 6;2020:9043012. Epub 2020 May 6.

Department of Clinical Immunology, Dalian Medical University, Dalian 116044, China.

Objective: To quantify the change in risk and aging factors with a two time point analysis for major cancers to assess supportive strategies.

Methods: The 2004 and 2015 mortality statistics in China were accessed. The standardized mortality rates of the two periods were used to calculate the ratio of change (RC) value to assess the risk of death associated with time (social development with time) for cancers. Read More

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http://dx.doi.org/10.1155/2020/9043012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229547PMC

Short-Term Results Suggest That Sleeved Stomach without Resection Is as Effective as Sleeve Gastrectomy in Improving Glucose Control in Type 2 Diabetes Mellitus Sprague-Dawley Rat Model.

Biomed Res Int 2020 1;2020:9024923. Epub 2020 May 1.

Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Jiangsu 221002, China.

Background: Although sleeve gastrectomy results in good weight loss and metabolic improvements, it is an irreversible procedure. Therefore, we attempted to assess the possibility of creating a sleeved stomach without resection. . Read More

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http://dx.doi.org/10.1155/2020/9024923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212312PMC

Patient Characteristics Related to Blood Loss in High Tibial Osteotomy in Novel Multiple Linear Regression Analysis.

Biomed Res Int 2020 1;2020:8965925. Epub 2020 May 1.

Department of Tianjin Hospital, Tianjin, China.

The purpose of the study was to identify patient characteristics related to blood loss following high tibial osteotomy (HTO). We evaluated 48 patients undergoing HTO from August 2018 to August 2019. The data of 48 patients were collected, including gender, age, height, weight, body mass index (BMI), smoking, alcohol consumption, hypertension, diabetes, history of aspirin, and pre-postoperative hematocrit (Hct). Read More

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http://dx.doi.org/10.1155/2020/8965925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212310PMC

Suppression of Autophagy via Lentiviral shRNA Targeting Atg5 Improves Lupus-Like Syndrome.

Biomed Res Int 2020 1;2020:8959726. Epub 2020 May 1.

Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei 112, Taiwan.

In both mouse models and clinical patients with lupus, autophagy levels were significantly elevated and correlated with disease activity. Furthermore, autophagy can promote the survival of B and T cells, plasma cell differentiation, and antibody production. These results suggest that autophagy may promote the progression of lupus by regulating the survival of autoreactive immune cells. Read More

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http://dx.doi.org/10.1155/2020/8959726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212279PMC

Biological Evaluation of Newly Synthesized Biaryl Guanidine Derivatives to Arrest -Secretase Enzymatic Activity Involved in Alzheimer's Disease.

Biomed Res Int 2020 11;2020:8934289. Epub 2020 May 11.

Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan.

Proteases BACE1 (-secretases) enzymes have been recognized as a promising target associated with Alzheimer's disease (AD). This study was carried out on the principles of molecular docking, chemical synthesis, and enzymatic inhibition of BACE1 enzymes via biaryl guanidine-based ligands. Based on virtual screening, thirteen different compounds were synthesized and subsequently evaluated via and studies. Read More

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http://dx.doi.org/10.1155/2020/8934289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238388PMC

Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis.

Biomed Res Int 2020 3;2020:8797284. Epub 2020 May 3.

Department of Biological Sciences, Faculty of Science, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.

Inflammatory diseases are a real public health problem worldwide. Many synthetic drugs used in the treatment of inflammatory diseases such as steroidal anti-inflammatory drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressive drugs have harmful side effects. However, there are natural products like propolis, which is traditionally used in the treatment of pain. Read More

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http://dx.doi.org/10.1155/2020/8797284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222486PMC

Corrigendum to "The Motoric Types of Delirium and Estimated Blood Loss during Perioperative Period in Orthopedic Elderly Patients".

Biomed Res Int 2020 9;2020:8753817. Epub 2020 May 9.

Department of Orthopaedic Surgery, Hallym University Sacred Heart Hospital College of Medicine, Hallym University, Anyang-si, Republic of Korea.

[This corrects the article DOI: 10.1155/2018/9812041.]. Read More

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http://dx.doi.org/10.1155/2020/8753817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243023PMC

Complete Chloroplast Genomes of 14 Mangroves: Phylogenetic and Comparative Genomic Analyses.

Biomed Res Int 2020 5;2020:8731857. Epub 2020 May 5.

BGI-Qingdao, BGI-Shenzhen, Qingdao 266555, China.

Mangroves are a group of plant species that occupy the coastal intertidal zone and are major components of this ecologically important ecosystem. Mangroves belong to about twenty diverse families. Here, we sequenced and assembled chloroplast genomes of 14 mangrove species from eight families spanning five rosid orders and one asterid order: Fabales (), Lamiales (), Malpighiales (, , , , and ), Malvales (, , and ), Myrtales (, , and ), and Sapindales (). Read More

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http://dx.doi.org/10.1155/2020/8731857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225854PMC

Integrated Bioinformatics Analysis of the Clinical Value and Biological Function of ATAD2 in Hepatocellular Carcinoma.

Biomed Res Int 2020 5;2020:8657468. Epub 2020 May 5.

Department of Gastric Surgery, Cancer Hospital of China Medical University/Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China.

ATPase family AAA domain-containing protein 2 (ATAD2), a chromatin regulator and an oncogenic transcription cofactor, is frequently overexpressed in many cancers, particularly in hepatocellular carcinoma (HCC). By integrating open-access online mRNA datasets and our institutional tissue data on HCC, the clinical role and functions of ATAD2 were analyzed by bioinformatic algorithms. We systematically examined ATAD2 expression in HCC based on a large sample population, integrating data from our institution and the GEO, Oncomine, and TCGA datasets. Read More

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http://dx.doi.org/10.1155/2020/8657468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225861PMC

. Extracts Protect H9c2 Cardiomyocytes against HO-Induced Apoptosis and Oxidative Stress.

Biomed Res Int 2020 2;2020:8379358. Epub 2020 May 2.

School of Public Health, Baotou Medical College, Baotou 014060, China.

Materials And Methods: The petroleum ether (petrol), dichloromethane (CHCl), ethyl acetate (EtOAc), and n-butyl alcohol (n-BuOH) fractions were isolated from alcohol extracts of . . Total phenolic and flavonoid contents and antioxidant activities of different fractions were evaluated. Read More

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http://dx.doi.org/10.1155/2020/8379358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222556PMC

Identification and Verification of Core Genes in Colorectal Cancer.

Biomed Res Int 2020 8;2020:8082697. Epub 2020 May 8.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.

Colorectal cancer, a malignant neoplasm that occurs in the colorectal mucosa, is one of the most common types of gastrointestinal cancer. Colorectal cancer has been studied extensively, but the molecular mechanisms of this malignancy have not been characterized. This study identified and verified core genes associated with colorectal cancer using integrated bioinformatics analysis. Read More

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http://dx.doi.org/10.1155/2020/8082697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232680PMC

Analysis of Lumbar Sagittal Curvature in Spinal Decompression and Fusion for Lumbar Spinal Stenosis Patients under Roussouly Classification.

Biomed Res Int 2020 1;2020:8078641. Epub 2020 May 1.

Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

To evaluate the clinical significance of spinal decompression and fusion for lumbar spinal stenosis in old patients under Roussouly classification, 160 old patients (>60 year old) with lumbar spinal stenosis underwent spinal decompression, and fusion were retrospectively studied. According to Roussouly classification, patients were divided into 4 groups, in which Roussouly types I, II, and IV were the nonstandard group and Roussouly type III was the standard group. Visual analog scale (waist, leg) and Oswestry disability index (ODI) scores were recorded before operation and at the final follow-up. Read More

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http://dx.doi.org/10.1155/2020/8078641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222496PMC

Procalcitonin Identifies Bacterial Coinfections in Vietnamese Children with Severe Respiratory Syncytial Virus Pneumonia.

Biomed Res Int 2020 9;2020:7915158. Epub 2020 May 9.

Faculty of Health Sciences, Thang Long University, Hanoi, Vietnam.

This study assessed the diagnostic value of interleukin- (IL-) 6, high-sensitivity C-reactive protein (hs-CRP), and procalcitonin (PCT) in differentiating severe pneumonia caused by respiratory syncytial virus (RSV) alone and RSV with bacterial coinfections among Vietnamese children under 5 years old. A cross-sectional study on 70 children with severe RSV pneumonia was conducted. IL-6, hs-CRP, and PCT tests were performed. Read More

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http://dx.doi.org/10.1155/2020/7915158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232683PMC

A New Computer-Aided Diagnosis System with Modified Genetic Feature Selection for BI-RADS Classification of Breast Masses in Mammograms.

Biomed Res Int 2020 11;2020:7695207. Epub 2020 May 11.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Mammography remains the most prevalent imaging tool for early breast cancer screening. The language used to describe abnormalities in mammographic reports is based on the Breast Imaging Reporting and Data System (BI-RADS). Assigning a correct BI-RADS category to each examined mammogram is a strenuous and challenging task for even experts. Read More

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http://dx.doi.org/10.1155/2020/7695207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238352PMC

The Effect of Different Treatment Regimens and Multiple Risk Factors on Adverse Pregnancy Outcomes among Syphilis-Seropositive Women in Guangzhou: A Retrospective Cohort Study.

Biomed Res Int 2020 1;2020:7626274. Epub 2020 May 1.

Department of Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: To eliminate mother-to-child transmission of syphilis, the Chinese government recommends a treatment regimen that slightly differs from the World Health Organization- (WHO-) recommended treatment. However, little is known about their difference in efficacy. This study is aimed at comparing the effect of China-recommended and WHO-recommend treatment regimens on adverse pregnancy outcomes (APOs) and at examining associated risk factors of APOs among syphilis-seropositive women. Read More

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http://dx.doi.org/10.1155/2020/7626274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222490PMC

A Static Magnetic Field Inhibits the Migration and Telomerase Function of Mouse Breast Cancer Cells.

Biomed Res Int 2020 11;2020:7472618. Epub 2020 May 11.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.

Static magnetic field (SMF) has a potential as a cancer therapeutic modality due to its specific inhibitory effects on the proliferation of multiple cancer cells. However, the underlying mechanism remains unclear, and just a few studies have examined the effects of SMF on metastasis, an important concern in cancer treatment. In this study, we evaluated the effects of moderate SMF (~150 mT) on the proliferation and migration of 4T1 breast cancer cells. Read More

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http://dx.doi.org/10.1155/2020/7472618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240788PMC

The Safety and Feasibility of Enhanced Recovery after Surgery in Patients Undergoing Pancreaticoduodenectomy: An Updated Meta-Analysis.

Biomed Res Int 2020 8;2020:7401276. Epub 2020 May 8.

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003 Zhejiang Province, China.

Background: Enhanced recovery after surgery (ERAS) is a multimodal, multidisciplinary, evidence-based approach to care for surgical patients and aims at optimizing the perioperative management and outcomes. The ERAS approach was first implemented in colorectal surgery patients; however, the reported applications in pancreatoduodenectomy patients are limited. In recent years, studies on ERAS for patients undergoing pancreaticoduodenectomy have been published. Read More

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http://dx.doi.org/10.1155/2020/7401276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232716PMC

Whole-Body Vibration for Individuals with Reconstructed Anterior Cruciate Ligament: A Systematic Review.

Biomed Res Int 2020 1;2020:7362069. Epub 2020 May 1.

Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: ACL ruptures are a prevalent condition, affecting daily living activities, associated with high financial burden.

Objective: To assess the effect of whole-body vibration (WBV) in the rehabilitation of patients with reconstructed anterior cruciate ligament. . Read More

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http://dx.doi.org/10.1155/2020/7362069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212274PMC

Gene Coexpression Network and Module Analysis across 52 Human Tissues.

Biomed Res Int 2020 2;2020:6782046. Epub 2020 May 2.

Academician Workstation, Changsha Medical University, Changsha 410219, China.

Gene coexpression analysis is widely used to infer gene modules associated with diseases and other clinical traits. However, a systematic view and comparison of gene coexpression networks and modules across a cohort of tissues are more or less ignored. In this study, we first construct gene coexpression networks and modules of 52 GTEx tissues and cell lines. Read More

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http://dx.doi.org/10.1155/2020/6782046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232734PMC

Urethral Diverticulum following Polypropylene Mesh Midurethral Slings: A Literature Review.

Biomed Res Int 2020 11;2020:6761581. Epub 2020 May 11.

Department of Obstetrics & Gynecology, West Virginia University School of Medicine, Morgantown, WV 26506, USA.

Aims: It is currently unknown whether an association exists between polypropylene mesh and urethral diverticulum formation following placement of polypropylene midurethral slings (MUS) for the treatment of stress urinary incontinence (SUI). We aimed to examine the literature associating MUS with the occurrence of urethral diverticula.

Methods: Multiple online research databases, including PubMed, Google Scholar, EBSCOhost, and the Cochrane Library, were searched, from January 2019 to February 2019, for evidence related to the occurrence of urethral diverticula following polypropylene MUS procedures. Read More

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http://dx.doi.org/10.1155/2020/6761581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240659PMC

Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways.

Biomed Res Int 2020 13;2020:6726759. Epub 2020 May 13.

Laboratory of Gastrointestinal Onco-Pathology, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.

The AT-hook transcription factor, AKNA, is a nuclear protein that affects a few physiological and pathological processes including cancer. Here, we investigated the role of in gastric cancer (GC). By using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, was found deregulated in both GC cell lines and 32 paired GC tissues. Read More

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http://dx.doi.org/10.1155/2020/6726759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243015PMC

Neuromuscular, Perceptual, and Temporal Determinants of Movement Patterns in Wheelchair Fencing: Preliminary Study.

Biomed Res Int 2020 4;2020:6584832. Epub 2020 May 4.

Faculty of Physical Education and Physiotherapy, Opole University of Technology, 45-758 Opole, Prószkowska 76, Poland.

The objective of the present study was to determine the structure of the movement pattern performed during a wheelchair fencing lunge that is executed in response to visual and sensory stimuli. In addition, a comparison was made between fencers in the categories A and B of disability. In addition, the analysis involved the correlation between the duration of the sensorimotor response and the value of the bioelectric signal recorded in selected muscles. Read More

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http://dx.doi.org/10.1155/2020/6584832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222494PMC

Extensively Drug-Resistant (XDR) Typhoid: Evolution, Prevention, and Its Management.

Biomed Res Int 2020 2;2020:6432580. Epub 2020 May 2.

Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan.

Typhoid fever is the result of a human host-restricted serotype typhi infection that causes enteric fever. Around 21 million people contract typhoid annually, with Pakistan's inhabitants at most risk amongst Asian countries where typhoid remains prevalent. Decades of indiscriminate antibiotic usage has driven the evolution of multidrug-resistant strains and more recently, extensively drug-resistant (XDR) strains of serotype typhi. Read More

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http://dx.doi.org/10.1155/2020/6432580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212280PMC

A Revised Surgical Strategy for the Distal Tibiofibular Interosseous Osteochondroma.

Biomed Res Int 2020 7;2020:6371456. Epub 2020 May 7.

Department of Orthopedic, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang 443002, China.

Osteochondroma is one of the most common benign bone tumor; however, the surgical treatment still remains a challenge for those that occur at the distal tibiofibular interosseous location. Previously, the transfibular approach has been successfully described, but the potential damage of the syndesmosis would give rise to the instability of the ankle joint and thus may result in the unfavorable long-term outcome. Here, a revised strategy which can protect the syndesmotic complex is introduced. Read More

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http://dx.doi.org/10.1155/2020/6371456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231068PMC

Uncuffed Endotracheal Tube Experience in Pediatric Patients with Laparotomy and Laparoscopic Surgeries.

Biomed Res Int 2020 9;2020:6325293. Epub 2020 May 9.

Department of Anesthesiology and Reanimation, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.

Aim: The aim of this study is to compare endotracheal tube leak, tube selection, mechanical ventilation, and side effects in the use of uncuffed tubes in both laparoscopic and laparotomy surgeries in pediatric patients. . Patients who underwent laparotomy (LT group) or laparoscopic (LS group) surgery between 1 and 60 months. Read More

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http://dx.doi.org/10.1155/2020/6325293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232717PMC

A Centralized Outbreak of Varicella among Children Attending Preschool in Suzhou, China.

Biomed Res Int 2020 2;2020:6183936. Epub 2020 May 2.

Suzhou National New and Hi-tech Industrial Development Zone Center for Disease Control and Prevention, Suzhou, Jiangsu 215011, China.

Background: Varicella vaccine is available for voluntary purchase with a single dose currently recommended for children aged ≥12 months. An epidemiological study was undertaken in order to determine the characteristics of the outbreak, assess vaccine effectiveness, and examine risk factors for vaccine failure.

Methods: A varicella case was defined as a generalized papulovesicular rash (without other apparent causes) in a child without prior varicella attending the kindergarten during February 22 to April 7 of 2016. Read More

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http://dx.doi.org/10.1155/2020/6183936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222484PMC

The Feasibility of All-Blastocyst-Culture and Single Blastocyst Transfer Strategy in Elderly Women: A Retrospective Analysis.

Biomed Res Int 2020 13;2020:5634147. Epub 2020 May 13.

Reproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

Objective: To investigate the feasibility and clinical outcome of the all-blastocyst-culture and single blastocyst transfer strategy in women aged ≥35 years.

Methods: A retrospective analysis of patients aged ≥35 years undergoing IVF/ICSI was performed from January 2017 to April 2019 in the reproductive center of the Second Affiliated Hospital of Wenzhou Medical University. A total of 155 cases treated with ovarian hyperstimulation by prolonged protocol and implemented single (84 cases) or double (71 cases) blastocyst transfer were collected. Read More

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http://dx.doi.org/10.1155/2020/5634147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243003PMC

Immunologic and Clinical Failure of Antiretroviral Therapy in People Living with Human Immunodeficiency Virus within Two Years of Treatment.

Biomed Res Int 2020 3;2020:5474103. Epub 2020 May 3.

School of Pharmacy, College of Health Sciences, Mekelle University, Ethiopia.

Background: Early initiation of highly active antiretroviral therapy (HAART) decreases human immunodeficiency virus- (HIV-) related complications, restores patients' immunity, decreases viral load, and substantially improves quality of life. However, antiretroviral treatment failure considerably impedes the merits of HAART.

Objective: This study is aimed at determining the prevalence of immunologic and clinical antiretroviral treatment failure. Read More

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http://dx.doi.org/10.1155/2020/5474103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222595PMC

The Optimal Regimen for the Treatment of Temporomandibular Joint Injury Using Low-Intensity Pulsed Ultrasound in Rats with Chronic Sleep Deprivation.

Biomed Res Int 2020 1;2020:5468173. Epub 2020 May 1.

Department of Dental Implant Center, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China.

Low-intensity pulsed ultrasound (LIPUS) is an emerging physical therapy for the treatment of early temporomandibular joint injury and has a good effect on promoting cartilage and subchondral bone tissue repair. However, the best LIPUS intensity and treatment duration remain unclear. This study is aimed at observing the preventive and therapeutic effects of different modes of LIPUS and at identifying the optimal LIPUS treatment regimen for temporomandibular joint injury. Read More

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http://dx.doi.org/10.1155/2020/5468173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212287PMC

Quantitative Assessment of Motor Function for Patients with a Stroke by an End-Effector Upper Limb Rehabilitation Robot.

Biomed Res Int 2020 8;2020:5425741. Epub 2020 Apr 8.

Division of Intelligent and Biomechanical System, State Key Laboratory of Tribology, Tsinghua University, Haidian, Beijing, China.

With the popularization of rehabilitation robots, it is necessary to develop quantitative motor function assessment methods for patients with a stroke. To make the assessment equipment easier to use in clinics and combine the assessment methods with the rehabilitation training process, this paper proposes an anthropomorphic rehabilitation robot based on the basic movement patterns of the upper limb, point-to-point reaching and circle drawing movement. This paper analyzes patients' movement characteristics in aspects of movement range, movement accuracy, and movement smoothness and the output force characteristics by involving 8 patients. Read More

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http://dx.doi.org/10.1155/2020/5425741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224306PMC

Identification and Validation of Prognostically Relevant Gene Signature in Melanoma.

Biomed Res Int 2020 8;2020:5323614. Epub 2020 May 8.

Department of Dermatology, The First Hospital of China Medical University, 110001 Shenyang, China.

Background: Currently, effective genetic markers are limited to predict the clinical outcome of melanoma. High-throughput multiomics sequencing data have provided a valuable approach for the identification of genes associated with cancer prognosis.

Method: The multidimensional data of melanoma patients, including clinical, genomic, and transcriptomic data, were obtained from The Cancer Genome Atlas (TCGA). Read More

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http://dx.doi.org/10.1155/2020/5323614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238332PMC

The Prevalence of Dental Caries in Primary Dentition in 3- to 5-Year-Old Preschool Children in Northern China.

Biomed Res Int 2020 10;2020:5315236. Epub 2020 May 10.

Department of Preventive Dentistry, School and Hospital of Stomatology, China Medical University, Shenyang, China 110002.

Objectives: To investigate the prevalence and factors promoting caries in primary dentition of 3-5-year-old children in Northeast China.

Materials And Methods: Data of 1,229 children aged 3 to 5 years were randomly selected. The caries prevalence and other indicators were assessed, and the results analyzed by SPSS. Read More

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http://dx.doi.org/10.1155/2020/5315236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238319PMC

Gene-Gene Interaction Analysis for the Survival Phenotype Based on the Kaplan-Meier Median Estimate.

Biomed Res Int 2020 9;2020:5282345. Epub 2020 May 9.

Department of Mathematics and Statistics, Sejong University, Seoul, Republic of Korea.

In this study, we propose a simple and computationally efficient method based on the multifactor dimensional reduction algorithm to identify gene-gene interactions associated with the survival phenotype. The proposed method, referred to as KM-MDR, uses the Kaplan-Meier median survival time as a classifier. The KM-MDR method classifies multilocus genotypes into a binary attribute for high- or low-risk groups using median survival time and replaces balanced accuracy with log-rank test statistics as a score to determine the best model. Read More

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http://dx.doi.org/10.1155/2020/5282345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232685PMC

Lanthanum Chloride Causes Neurotoxicity in Rats by Upregulating miR-124 Expression and Targeting PIK3CA to Regulate the PI3K/Akt Signaling Pathway.

Biomed Res Int 2020 5;2020:5205142. Epub 2020 May 5.

Institute of Molecular Medicine, Medical School, Eastern Liaoning University, Dandong Liaoning 118003, China.

Background: Lanthanum (La) exposure can cause central nervous system (CNS) damage and dysfunction in children, seriously affecting intellectual development. miR-124 plays an important role in the development of the nervous system. We exposed rats to a La environment then observed the rats' learning and memory damage and neurotoxicity and the relationship with miR-124. Read More

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http://dx.doi.org/10.1155/2020/5205142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222569PMC

JMJD1A Represses the Development of Cardiomyocyte Hypertrophy by Regulating the Expression of .

Biomed Res Int 2020 12;2020:5081323. Epub 2020 May 12.

Department of Anesthesiology, First Affiliated Hospital of Jiamusi University, Heilongjiang Province, China.

The histone demethylase JMJD family is involved in various physiological and pathological functions. However, the roles of JMJD1A in the cardiovascular system remain unknown. Here, we studied the function of JMJD1A in cardiac hypertrophy. Read More

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http://dx.doi.org/10.1155/2020/5081323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243027PMC

Malnutrition-Related Factors Increased the Risk of Anastomotic Leak for Rectal Cancer Patients Undergoing Surgery.

Authors:
Hao Xu Fanmin Kong

Biomed Res Int 2020 30;2020:5059670. Epub 2020 Apr 30.

Department of Gastrointestinal Surgery, The First Hospital of China Medical University, Shenyang, China.

Objective: To study the possible risk factors and related prediction indexes of anastomotic leakage (AL) in patients with rectal cancer during the perioperative period and to provide effective indexes for predicting whether AL will occur in postoperative patients with rectal cancer and whether early nutritional support is needed.

Background: AL after rectal cancer surgery is a common and serious complication. Many of the risk factors for AL have been confirmed. Read More

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http://dx.doi.org/10.1155/2020/5059670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212272PMC

The Efficacy and Safety of PD-1/PD-L1 Inhibitors in Combination with Conventional Therapies for Advanced Solid Tumors: A Meta-Analysis.

Biomed Res Int 2020 6;2020:5059079. Epub 2020 May 6.

Department of Gastric Surgery, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Objectives: To evaluate the efficacy of immuno-oncology combinational therapy (IOCT) versus monotherapy with programmed cell death 1 (PD-1) or PD-ligand 1 (PD-L1) inhibitors or conventional therapies, i.e., non-IOCT, in patients with advanced solid tumors. Read More

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http://dx.doi.org/10.1155/2020/5059079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225910PMC

Histopathology of Cutaneous Leishmaniasis Caused by in Sri Lanka.

Biomed Res Int 2020 2;2020:4926819. Epub 2020 May 2.

Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka.

Cutaneous leishmaniasis (CL) is a neglected tropical disease that is gaining importance in Sri Lanka and internationally. The clinical presentation, pathology, and method of parasite elimination in CL vary according to the species. is the causative organism for leishmaniasis in Sri Lanka. Read More

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http://dx.doi.org/10.1155/2020/4926819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222607PMC

Heme Oxygenase-1 Suppresses Wnt Signaling Pathway in Nonalcoholic Steatohepatitis-Related Liver Fibrosis.

Biomed Res Int 2020 1;2020:4910601. Epub 2020 May 1.

Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, China.

Methods: Mice were fed with a methionine-choline-deficient (MCD) diet for 8 weeks to induce steatohepatitis-related liver fibrosis and were treated with HO-1 inducer Hemin and inhibitor ZnPP. Mouse sera were collected for the biochemical analysis, and livers were obtained for further histological observation and gene expression analysis. HSC-T6 cells were cultured for the study and were administrated with Hemin and si-HO-1 to induce or inhibit the expression of HO-1. Read More

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http://dx.doi.org/10.1155/2020/4910601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212281PMC

Evaluation of Zhenwu Decoction Effects on CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS.

Biomed Res Int 2020 12;2020:4816209. Epub 2020 May 12.

Institute of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.

This thesis is aimed at shedding light on the effects of the Zhenwu decoction (ZWD) on the activities and mRNA expressions of seven CYP450 isoenzymes. In the first step, we determined the main chemical compounds of ZWD by high-performance liquid chromatography (HPLC). Next, 48 male (SD) rats were randomly divided into the normal saline (NS) group and the ZWD low- (2. Read More

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http://dx.doi.org/10.1155/2020/4816209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240782PMC