15,674 results match your criteria BioMed research international[Journal]


Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan Women.

Biomed Res Int 2019 12;2019:6235680. Epub 2019 Mar 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting women of reproductive age. Its aetiology, though yet unclear, is presumed to have an oligogenic basis interacting with environmental factors. Kisspeptins are peptide products of Kiss1 gene that control the hypothalamic pituitary (HPG) axis by acting via G protein-coupled receptor known as GPR54. Read More

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https://www.hindawi.com/journals/bmri/2019/6235680/
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http://dx.doi.org/10.1155/2019/6235680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434290PMC
March 2019
1 Read

Potential Regulatory Effects of miR-182-3p in Osteosarcoma via Targeting EBF2.

Biomed Res Int 2019 12;2019:4897905. Epub 2019 Mar 12.

Department of Orthopedics, the Second Hospital of Jilin University, Ziqiang Street 218, Changchun, Jilin 130041, China.

Osteosarcoma (OS) is one of the most common primary malignant bone tumors in adolescents with a high mortality rate. MicroRNA (miRNA) is a kind of noncoding RNAs and has been proved to participate in many physiological processes. Many miRNAs have been reported to act as function regulators in OS. Read More

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http://dx.doi.org/10.1155/2019/4897905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434304PMC

Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells.

Biomed Res Int 2019 12;2019:3851718. Epub 2019 Mar 12.

Division of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430070, China.

We examined whether and how uric acid induces epithelial to mesenchymal transition (EMT) in renal tubular cells, along with the mechanism by which telmisartan acts on uric acid-induced renal injury. Rat renal proximal tubular epithelial cells (NRK-52E) were exposed to various concentrations of uric acid in the presence or absence of telmisartan. Treatment with uric acid increased the expression of -SMA, decreased the expression of E-cadherin, and promoted EMT in NRK-52E cells. Read More

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http://dx.doi.org/10.1155/2019/3851718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434300PMC

Chemical and Bioactivity Evaluation of and Polyphenolic-Rich Extracts.

Biomed Res Int 2019 12;2019:3692605. Epub 2019 Mar 12.

National Institute for Research-Development of Biological Sciences, Bucharest 6, 060031, Romania.

This study evaluated the biological activities of and extracts enriched in polyphenols obtained by nanofiltration. The HPLC-MS analysis showed that contains mainly flavonoids, especially rutin, while in extracts show the high concentration of the phenolic acids, principally the chlorogenic acid and sinapic acid. Herein, there is the first report of ursolic acid, genistin, and isorhamnetin in and polyphenolic-rich extract showed high scavenging activity (IC=0. Read More

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https://www.hindawi.com/journals/bmri/2019/3692605/
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http://dx.doi.org/10.1155/2019/3692605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434295PMC
March 2019
1 Read

Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis.

Biomed Res Int 2019 12;2019:1434538. Epub 2019 Mar 12.

Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Osteoarthritis (OA) is a chronic degenerative joint disease, where chondrocyte apoptosis is responsible for cartilage degeneration. Bax is a well-known proapoptotic protein of the Bcl-2 family, involved in a large number of physiological and pathological processes. However, the regulation mechanisms of Bax underlying chondrocyte apoptosis in OA remain unknown. Read More

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https://www.hindawi.com/journals/bmri/2019/1434538/
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http://dx.doi.org/10.1155/2019/1434538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434297PMC
March 2019
1 Read

Bone Marrow Derived Mesenchymal Stromal Cells Ameliorate Ischemia/Reperfusion Injury-Induced Acute Kidney Injury in Rats via Secreting Tumor Necrosis Factor-Inducible Gene 6 Protein.

Biomed Res Int 2019 11;2019:9845709. Epub 2019 Mar 11.

Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.

Aims: To investigate whether bone marrow derived mesenchymal stromal cells (BMSC) have ameliorated ischemia/reperfusion injury-induced acute kidney injury (IRI-AKI) via tumor necrosis factor-inducible gene 6 protein (TSG-6) and how TSG-6 exerted this effect.

Methods: We used lentiviral vectors of short hairpin RNA (shRNA) targeting TSG-6 gene to silence TSG-6 in BMSC. And TSG-6-silenced BMSC were administrated into IRI-AKI rats. Read More

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https://www.hindawi.com/journals/bmri/2019/9845709/
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http://dx.doi.org/10.1155/2019/9845709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432703PMC
March 2019
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Low Expression of hsa_circ_0018069 in Human Bladder Cancer and Its Clinical Significance.

Biomed Res Int 2019 10;2019:9681863. Epub 2019 Mar 10.

Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.

Abnormal expression of noncoding RNA molecules such as circRNA plays an important role in the development of malignant tumors. circRNAs are stable in structure and can be useful as ideal tumor markers. Advanced bladder cancer has poor treatment options and prognosis. Read More

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http://dx.doi.org/10.1155/2019/9681863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431508PMC

Corrigendum to "Old and New NICE Guidelines for the Evaluation of New Onset Stable Chest Pain: A Real World Perspective".

Biomed Res Int 2019 7;2019:9637490. Epub 2019 Mar 7.

Cardiovascular and Thoracic Department of Careggi Hospital, Florence, Italy.

[This corrects the article DOI: 10.1155/2018/3762305.]. Read More

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http://dx.doi.org/10.1155/2019/9637490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431469PMC

Association between Gamma-Glutamyl Transferase and Coronary Atherosclerotic Plaque Vulnerability: An Optical Coherence Tomography Study.

Biomed Res Int 2019 4;2019:9602783. Epub 2019 Mar 4.

Department of Coronary Heart Disease, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.

Background: Gamma-glutamyl transferase (GGT) has been detected in coronary plaques. However, the association between serum GGT levels and coronary atherosclerotic plaque vulnerability in patients with coronary artery disease (CAD) as detected by optical coherence tomography (OCT) has not been investigated.

Methods: We performed a retrospective study of consecutively enrolled CAD patients undergoing preintervention OCT examination during coronary angiography. Read More

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http://dx.doi.org/10.1155/2019/9602783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432723PMC

Corrigendum to "Potential of Gene and Cell Therapy for Inner Ear Hair Cells".

Biomed Res Int 2019 7;2019:9601260. Epub 2019 Mar 7.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.

[This corrects the article DOI: 10.1155/2018/8137614.]. Read More

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http://dx.doi.org/10.1155/2019/9601260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431518PMC

Correlation between Testicular Hemodynamic and Semen Quality Indices in Clinical Varicocele Patients in Pakistan.

Biomed Res Int 2019 7;2019:7934328. Epub 2019 Mar 7.

Department of Physiology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Varicocele, a vascular event, is associated with infertility due to testicular damage that causes abnormal spermatogenesis in males. The goal of this study is to ascertain the diagnostic significance of scrotal color Doppler ultrasonography (CDUS) by measuring peak systolic value (PSV) and resistive index (RI) of the arteries supplying blood to the testis and their association with semen quality attributes. Sixty prospective patients (age: 20-50 years) undergoing microsurgical varicocelectomy at a teaching hospital were included in the study. Read More

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http://dx.doi.org/10.1155/2019/7934328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431503PMC

SNP Typing Using Multiplex Real-Time PCR Assay for Species Identification of Forensically Important Blowflies and Fleshflies Collected in South Korea (Diptera: Calliphoridae and Sarcophagidae).

Biomed Res Int 2019 11;2019:6762517. Epub 2019 Mar 11.

Department of Legal Medicine, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

Medicolegal entomology-a subfield of forensic entomology-is mainly used in medicolegal investigations to estimate the postmortem interval (PMI). The minimum PMI of a corpse invaded by necrophagous immature insects can be estimated because the PMI is near to or earlier than the oviposition time of the larvae that hatched and fed on the corpse. As the growth speeds of larvae differ depending on temperature and species, species-specific growth data are used to estimate the minimum PMI. Read More

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http://dx.doi.org/10.1155/2019/6762517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432722PMC

Reversing Effect of Insulin on Local Anesthetics-Induced Sciatic Nerve Block in Rats.

Biomed Res Int 2019 11;2019:4252349. Epub 2019 Mar 11.

Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.

Background: Local anesthetics are used in various purposes from topical and infiltration anesthesia to peripheral nerve or central neural blockade. Even though local anesthetics are relatively safe, they can have some toxic and adverse effects. Prolonged sensory and motor block is another example of an unwanted complication. Read More

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http://dx.doi.org/10.1155/2019/4252349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432733PMC

Extensive Use of 3D Nonfluoroscopic Mapping Systems for Reducing Radiation Exposure during Catheter Ablation Procedures: An Analysis of 10 Years of Activity.

Biomed Res Int 2019 10;2019:4217076. Epub 2019 Mar 10.

Department of Cardiology, S. Chiara Hospital, Trento, Italy.

Purpose: 3D nonfluoroscopic mapping systems (NMSs) are generally used in the catheter ablation (CA) of complex ventricular and atrial arrhythmias. The aim of this study was to evaluate the efficacy, safety, and long-term effect of the extended, routine use of NMSs for CA.

Methods: Our study involved 1028 patients who underwent CA procedures from 2007 to 2016. Read More

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http://dx.doi.org/10.1155/2019/4217076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431475PMC

Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation.

Biomed Res Int 2019 11;2019:3102414. Epub 2019 Mar 11.

Department of Nursing, Chung Hwa University of Medical Technology, Tainan 71703, Taiwan.

Etifoxine, an 18 kDa translocator protein (TSPO) agonist for the treatment of anxiety disorders in clinic, may be able to cause acute liver injury or cytolytic hepatitis. TSPO has been demonstrated to participate in inflammatory responses in infective diseases as well as to modulate glucose and lipid homeostasis. Hepatitis C virus (HCV) infection disrupts glucose and lipid homoeostasis, leading to insulin resistance (IR). Read More

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https://www.hindawi.com/journals/bmri/2019/3102414/
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http://dx.doi.org/10.1155/2019/3102414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432734PMC
March 2019
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Efficacy of a Methanolic Extract of Leaf in Alleviating Hyperglycemia, Hyperlipidemia, and Oxidative Stress of Diabetic Rats.

Biomed Res Int 2019 7;2019:2835152. Epub 2019 Mar 7.

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Traditionally, in many countries, various parts of the () tree have been used in the treatment of many clinical ailments including diarrhea and dysentery. The phytochemical screening has indicated that the leaf extract of contains flavonoids, saponins, mucilage, steroids, and alkaloids. Thus, this paper aims to evaluate the hyperglycaemic and hypolipidaemic effects of methanolic extract of leaves (200 mg/kg and 400 mg/kg) in diabetic rats. Read More

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http://dx.doi.org/10.1155/2019/2835152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431509PMC

Quantitative Proteomic Analysis of Human Seminal Plasma from Normozoospermic and Asthenozoospermic Individuals.

Biomed Res Int 2019 10;2019:2735038. Epub 2019 Mar 10.

Central Laboratory, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214000, China.

Seminal plasma is a complex mixture of secretions from various glands in the male genital tract. Compared to sperm cells, it contains important proteins that are both directly and indirectly associated with sperm motility. Here, we constructed quantitative proteomes of human seminal plasma from three normozoospermic and asthenozoospermic individuals. Read More

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http://dx.doi.org/10.1155/2019/2735038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431472PMC

Value of 3D Preoperative Planning for Primary Total Hip Arthroplasty Based on Biplanar Weightbearing Radiographs.

Biomed Res Int 2019 10;2019:1932191. Epub 2019 Mar 10.

Service de Chirurgie Orthopédique, Traumatologique et Arthroscopique, Hôpital Central, CHRU Nancy, Av de Lattre de Tassigny, 54000 Nancy, France.

Two-dimensional (2D) planning on standard radiographs for total hip arthroplasty may not be sufficiently accurate to predict implant sizing or restore leg length and femoral offset, whereas 3D planning avoids magnification and projection errors. Furthermore, weightbearing measures are not available with computed tomography (CT) and leg length and offset are rarely checked postoperatively using any imaging modality. Navigation can usually achieve a surgical plan precisely, but the choice of that plan remains key, which is best guided by preoperative planning. Read More

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http://dx.doi.org/10.1155/2019/1932191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431504PMC

Combined Activation of Guanylate Cyclase and Cyclic AMP in Lung Fibroblasts as a Novel Therapeutic Concept for Lung Fibrosis.

Biomed Res Int 2019 7;2019:1345402. Epub 2019 Mar 7.

Pulmonary Cell Research, Department of Biomedicine and Pneumology, Department of Internal Medicine, University Hospital and University of Basel, Switzerland.

Remodelling of the peripheral lung tissue and fibrotic foci are the main pathologies of idiopathic pulmonary fibrosis (IPF), a disease that is difficult to treat. TGF- activation of peripheral lung fibroblasts is indicated as the major cause of tissue remodelling in IPF and is resulting in fibroblast hyperplasia and deposition of extracellular matrix. Soluble guanylate cyclase (sGC) stimulators combined with cyclic AMP (cAMP) activators have been reported to reduce proliferation and matrix deposition in other conditions than IPF. Read More

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https://www.hindawi.com/journals/bmri/2019/1345402/
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http://dx.doi.org/10.1155/2019/1345402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431482PMC
March 2019
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The Diagnostic Value of Quantitative CT Analysis of Ground-Glass Volume Percentage in Differentiating Epidermal Growth Factor Receptor Mutation and Subtypes in Lung Adenocarcinoma.

Biomed Res Int 2019 6;2019:9643836. Epub 2019 Mar 6.

Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Objective: To retrospectively investigate computed tomographic (CT) quantitative analysis of ground-glass opacity (GGO) volume percentage and morphologic features of resected lung adenocarcinomas according to epidermal growth factor receptor () mutation status and subtypes.

Methods: Amplification refractory mutation system was used to detect mutations in the EGFR gene. Distribution of demographics and GGO volume percentage were performed according to EGFR mutation status and subtypes. Read More

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http://dx.doi.org/10.1155/2019/9643836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431394PMC

Acceptance and Use of Innovative Assistive Technologies among People with Cognitive Impairment and Their Caregivers: A Systematic Review.

Biomed Res Int 2019 6;2019:9196729. Epub 2019 Mar 6.

Department of Health Sciences, Faculty of Medicine, Lund University, Lund 221 00, Sweden.

Cognitive impairments (CI), associated with the consequences of Alzheimer's disease and other dementias, are increasingly prevalent among older adults, leading to deterioration in self-care, mobility, and interpersonal relationships among them. Innovative Assistive Technologies (IAT) such as electronic reminders and surveillance systems are considered as increasingly important tools to facilitate independence among this population and their caregivers. The aim of this study is to synthesise knowledge on facilitators and barriers related to acceptance of and use of IAT among people with CI and their caregivers. Read More

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http://dx.doi.org/10.1155/2019/9196729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431399PMC

Comparison of the Intestinal Microbial Community in Ducks Reared Differently through High-Throughput Sequencing.

Biomed Res Int 2019 10;2019:9015054. Epub 2019 Mar 10.

University College of Veterinary & Animal Sciences, The Islamia University of Bahawalpur, 63100, Pakistan.

Birds are an important source of fecal contamination in environment. Many of diseases are spread through water contamination caused by poultry droppings. A study was conducted to compare the intestinal microbial structure of Shaoxing ducks with and without water. Read More

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http://dx.doi.org/10.1155/2019/9015054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431443PMC

Relevance of Topographic Parameters on the Adhesion and Proliferation of Human Gingival Fibroblasts and Oral Bacterial Strains.

Biomed Res Int 2019 10;2019:8456342. Epub 2019 Feb 10.

Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Avda de Elvas s/n, 06006 Badajoz, Spain.

Dental implantology allows replacement of failing teeth providing the patient with a general improvement of health. Unfortunately not all reconstructions succeed, as a consequence of the development of infections of bacterial origin on the implant surface. Surface topography is known to modulate a differential response to bacterial and mammalian cells but topographical measurements are often limited to vertical parameters. Read More

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http://dx.doi.org/10.1155/2019/8456342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431371PMC
February 2019

The Differential Expression of miRNAs and a Preliminary Study on the Mechanism of miR-194-3p in Keloids.

Biomed Res Int 2019 7;2019:8214923. Epub 2019 Mar 7.

Department of Plastic and Reconstructive Surgery, The General Hospital of North Theater, PLA, Shenyang, China.

The aim of this study was to detect abnormally expressed microRNA (miRNA) in keloids and to study their functions. The differential expression of miRNAs in keloids and normal tissue was detected by gene microarray. MiRNA expression was verified by real-time PCR. Read More

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http://dx.doi.org/10.1155/2019/8214923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431430PMC
March 2019
1 Read

Ruxolitinib for Therapy of Graft-versus-Host Disease.

Biomed Res Int 2019 6;2019:8163780. Epub 2019 Mar 6.

University Medicine Greifswald, Internal Medicine C, Hematology and Oncology, Stem Cell Transplantation and Palliative Care, Ferdinand-Sauerbruch-Strasse, 17475 Greifswald, Germany.

Objective: Steroid-resistant graft-versus-host disease (GvHD) is a major challenge after allogeneic stem cell transplantation and associated with significant morbidity and mortality. There is no therapeutic standard defined beyond calcineurin inhibitors (CNI) and steroids. Furthermore, some patients may have contraindications against CNI or high-dose steroids. Read More

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http://dx.doi.org/10.1155/2019/8163780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431395PMC

Outcomes of Myomectomy at the Time of Cesarean Section among Pregnant Women with Uterine Fibroids: A Retrospective Cohort Study.

Biomed Res Int 2019 10;2019:7576934. Epub 2019 Mar 10.

Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Objective: A retrospective study was performed to evaluate the safety and feasibility of cesarean myomectomy among pregnant women with uterine fibroids (UFs).

Methods: Upon data collection, the pregnant women with UF underwent cesarean section in the 39 hospital divided into two groups: cesarean myomectomy group, receiving cesarean section and myomectomy; cesarean group, receiving cesarean section only. Information about the type, location, and number of UFs was collected from the medical records or the prenatal ultrasound examinations. Read More

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https://www.hindawi.com/journals/bmri/2019/7576934/
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http://dx.doi.org/10.1155/2019/7576934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431434PMC
March 2019
4 Reads

Does Pharmacological Treatment Reduce the Incidence of Lower Urinary Tract Symptoms (LUTS) after Transobturator Sling?

Biomed Res Int 2019 6;2019:7271289. Epub 2019 Mar 6.

2 Department of Gynecology, Medical University of Lublin, Lublin, Poland.

Aim: Lower urinary tract symptoms (LUTS) frequently affect patients immediately after midurethral sling (MUS) placement. The objective of the study was to assess if solifenacin or mirabegron decreases incidence of LUTS in women who underwent transobturator MUS.

Methods: A prospective randomized trial was conducted on patients undergoing ambulatory transobturator midurethral sling due to stress urinary incontinence (SUI). Read More

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http://dx.doi.org/10.1155/2019/7271289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431360PMC

Genetic Modification for Wheat Improvement: From Transgenesis to Genome Editing.

Biomed Res Int 2019 10;2019:6216304. Epub 2019 Mar 10.

College of Science and Engineering, Biological Sciences, Flinders University, Bedford Park, SA, Australia.

To feed the growing human population, global wheat yields should increase to approximately 5 tonnes per ha from the current 3.3 tonnes by 2050. To reach this goal, existing breeding practices must be complemented with new techniques built upon recent gains from wheat genome sequencing, and the accumulated knowledge of genetic determinants underlying the agricultural traits responsible for crop yield and quality. Read More

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http://dx.doi.org/10.1155/2019/6216304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431451PMC

Wheelchair Tilt-in-Space and Recline Functions: Influence on Sitting Interface Pressure and Ischial Blood Flow in an Elderly Population.

Biomed Res Int 2019 6;2019:4027976. Epub 2019 Mar 6.

ETH Zurich, Institute for Biomechanics, 8093 Zurich, Switzerland.

Pressure ulcers (PUs) result from localised injury to the skin and underlying tissue and usually occur over a bony prominence as a result of pressure, often in combination with shear forces. Both pressure magnitude and duration are thought to be key risk factors in the occurrence of PUs, thus exposing wheelchair-bound subjects to high risk of PU development. As a result, wheelchairs that incorporate tilt-in-space and recline functions are routinely prescribed to redistribute pressure away from their ischial tuberosities. Read More

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https://www.hindawi.com/journals/bmri/2019/4027976/
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http://dx.doi.org/10.1155/2019/4027976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431370PMC
March 2019
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Microarray Based Functional Analysis of Myricetin and Proteomic Study on Its Anti-Inflammatory Property.

Biomed Res Int 2019 7;2019:3746326. Epub 2019 Mar 7.

Core Research Program 1515, Key Laboratory for Food Science and Biotechnology of Hunan Province, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.

Myricetin has been reported as a promising chemopreventive compound with multiple biofunctions. To evaluate its influence on gene expressions in genome-wide set and further investigate its anti-inflammatory property, the present study performed Gene Ontology and Ingenuity Pathway Analysis (IPA) to describe the basic gene expression characteristics by myricetin treatment in HepG2 cells, confirmed its multi-biofunction by real-time fluorescent quantitative PCR (RT-qPCR), and further verified its anti-inflammatory property by Western blotting and bio-plex-based cytokines assay. The IPA data showed that 337 gene expressions (48% of the top molecules) are disturbed over 2-fold, and the most possible biofunctions of myricetin are the effect on "cardiovascular disease, metabolic disease, and lipid metabolism," via regulation of 28 molecules with statistic score of 46. Read More

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http://dx.doi.org/10.1155/2019/3746326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431437PMC

A Rat Model of Radiation Vasculitis for the Study of Mesenchymal Stem Cell-Based Therapy.

Biomed Res Int 2019 6;2019:3727635. Epub 2019 Mar 6.

Department of Vascular Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Radiation vasculitis is one of the most common detrimental effects of radiotherapy for malignant tumors. This is developed at the vasculature of adjacent organs. Animal experiments have showed that transplantation of mesenchymal stem cells (MSCs) restores vascular function after irradiation. Read More

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http://dx.doi.org/10.1155/2019/3727635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431386PMC

SLC9A3 Affects Vas Deferens Development and Associates with Taiwanese Congenital Bilateral Absence of the Vas Deferens.

Biomed Res Int 2019 10;2019:3562719. Epub 2019 Mar 10.

Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.

Background: The pathophysiology of Taiwanese congenital bilateral absence of the vas deferens (CBAVD) is different from that in Caucasians. In particular, major cystic fibrosis transmembrane conductance regulator (CFTR) mutations and cystic fibrosis are absent in the former. Instead, deficiency in solute carrier family 9 sodium/hydrogen exchanger isoform 3 (SLC9A3) may play a role by generating obstructive azoospermia and degraded epithelial structure in the reproductive tract. Read More

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http://dx.doi.org/10.1155/2019/3562719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431446PMC
March 2019
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Population Pharmacokinetics of Clozapine and Norclozapine and Switchability Assessment between Brands in Uruguayan Patients with Schizophrenia.

Biomed Res Int 2019 6;2019:3163502. Epub 2019 Mar 6.

C Pediatrics Clinics, Pereira Rossell Hospital, Bulevar Gral. Artigas 1550, 11600 Montevideo, Faculty of Medicine, Universidad de la República, Uruguay.

Clozapine (CZP) is an atypical antipsychotic agent commonly used in the treatment of schizophrenia. It is metabolized primarily by CYP1A2 enzyme, yielding a pharmacologically active metabolite, norclozapine (NCZP). Significant intra- and interindividual pharmacokinetic (PK) variability for CZP and NCZP has been observed in routine therapeutic drug monitoring. Read More

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http://dx.doi.org/10.1155/2019/3163502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431368PMC

Prevents Increase of Hippocampal Tumor Necrosis Factor-α Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress.

Biomed Res Int 2019 6;2019:2649281. Epub 2019 Mar 6.

Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.

ameliorates memory impairment and induces expression of hippocampal brain-derived neurotropic factor (BDNF) in chronically stressed rats. The relationship between the anti-inflammatory effect of on hippocampal BDNF and the involvement of sirtuin-1, a BDNF expression regulator, in neuroprotective mechanisms of warrants an investigation. We investigated the effect of ethanolic extracts (CA) on TNF-, IL-10, and SIRT1 levels and whether these predicted BDNF expression in rat hippocampus after chronic stress. Read More

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http://dx.doi.org/10.1155/2019/2649281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431365PMC

The Effect of Tanreqing Injection on the Pharmacokinetics of Sirolimus in Rats.

Biomed Res Int 2019 10;2019:1854323. Epub 2019 Mar 10.

Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

To evaluate the effect of Tanreqing injection on the pharmacokinetics of sirolimus in rats, a high performance liquid chromatography tandem mass spectrometry method was developed for sirolimus assay in whole blood. Calibration curve of sirolimus was acquired over a concentration ranging from 2.5 to 100 ng/mL with r= 0. Read More

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http://dx.doi.org/10.1155/2019/1854323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431440PMC
March 2019
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Rosmarinic Acid Enriched Fraction from Leaves Strongly Protects Indomethacin-Induced Gastric Ulcer in Rats.

Biomed Res Int 2019 4;2019:9514703. Epub 2019 Mar 4.

Division of Biochemistry, School of Medical Sciences, University of Phayao, 56000 Phayao, Thailand.

Gastric ulcers are a common problem in upper gastrointestinal tract (GI) disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most aggressive factors leading to inducing gastric ulcers. Natural products with lower toxicity and safety are currently sought as a potential source to minimize the effect of the gastric ulcers. Read More

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http://dx.doi.org/10.1155/2019/9514703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425344PMC

Positive Correlation between Activated CypA/CD147 Signaling and MMP-9 Expression in Mice Inflammatory Periapical Lesion.

Biomed Res Int 2019 5;2019:8528719. Epub 2019 Mar 5.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine Ministry of Education, Wuhan University, Wuhan 430000, China.

Aim: Cyclophilin A (CypA)/CD147 signaling plays critical roles in the regulation of inflammation and bone metabolism. This study aimed to investigate the participation of CypA/CD147 in mice periapical lesions progression and its relationship with bone resorption.

Methodology: Periapical lesions were induced by pulp exposure in the first lower molars of 40 C57BL/6J mice. Read More

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https://www.hindawi.com/journals/bmri/2019/8528719/
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http://dx.doi.org/10.1155/2019/8528719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425416PMC
March 2019
1 Read

Prevalence and Predictors of Obesity and Overweight among Adults Visiting Primary Care Settings in the Southwestern Region, Saudi Arabia.

Biomed Res Int 2019 5;2019:8073057. Epub 2019 Mar 5.

Department of Family and Community Medicine, College of Medicine, Najran University, Najran, Saudi Arabia.

Introduction: Obesity is becoming the most common health problem of the 21st century, as it will contribute significantly to the high prevalence of cardiovascular disease in developing countries. The main objective of our study was to estimate the prevalence of obesity and overweight among adults attending primary health care settings, southwestern region of the Kingdom of Saudi Arabia.

Methods: The studied population was composed of adults visiting primary health care centres in the southwestern region of Saudi Arabia. Read More

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http://dx.doi.org/10.1155/2019/8073057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425323PMC

Highly Soluble Drugs Directly Granulated by Water Dispersions of Insoluble Eudragit® Polymers as a Part of Hypromellose K100M Matrix Systems.

Biomed Res Int 2019 5;2019:8043415. Epub 2019 Mar 5.

Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.

The aim of the present study was to investigate the suitability of insoluble Eudragit® water dispersions (NE, NM, RL, and RS) for direct high-shear granulation of very soluble levetiracetam in order to decrease its from HPMC K100M matrices. The process characteristics, ss-NMR analysis, dissolution behavior, drug release mechanism and kinetics, texture profile analysis of the gel layer, and PCA analysis were explored. An application of water dispersions directly on levetiracetam was feasible only in a multistep process. Read More

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http://dx.doi.org/10.1155/2019/8043415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425467PMC

The Attributable Direct Medical Cost of Healthcare Associated Infection Caused by Multidrug Resistance Organisms in 68 Hospitals of China.

Biomed Res Int 2019 5;2019:7634528. Epub 2019 Mar 5.

Peking University First Hospital, Beijing 100034, China.

Healthcare associated infection (HAI) is known to increase the economic burden of patients while the medical cost due to MDRO HAI is even higher. Three hundred eighty-one multidrug resistance organisms (MDROs) healthcare associated infection (HAI) case-patients and three hundred eighty-one matched control-patients were identified between January and December in 2015. The average total hospitalization medical cost of the case group was $6127. Read More

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http://dx.doi.org/10.1155/2019/7634528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425381PMC

Interleukin-1 Beta Gene Polymorphism rs16944 May Associate with Increased Susceptibility to Extremity Chronic Osteomyelitis in Chinese Han Population.

Biomed Res Int 2019 4;2019:7483537. Epub 2019 Mar 4.

Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Background: Previous studies had indicated that interleukin-1 beta (IL-1) gene single nucleotide polymorphisms (SNPs) associate with different inflammatory diseases. However, potential links between these polymorphisms and susceptibility to extremity chronic osteomyelitis (COM) remain unclear. This study aimed to investigate relationships between IL-1 gene polymorphisms (rs16944, rs1143627, rs1143634, and rs2853550) and risks of developing extremity COM in Chinese Han population. Read More

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http://dx.doi.org/10.1155/2019/7483537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425336PMC

Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis.

Biomed Res Int 2019 4;2019:7272045. Epub 2019 Mar 4.

Department of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.

Background: Some studies have reported that renal dysfunction is associated with poor prognosis in cirrhotic patients. Serum cystatin C (CysC) is an accurate biomarker for early renal dysfunction. This study aimed to assess the prognostic value of serum CysC levels in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi). Read More

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http://dx.doi.org/10.1155/2019/7272045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425319PMC

Juvenile Ovine Ex Vivo Larynges: Phonatory, Histologic, and Micro CT Based Anatomic Analyses.

Biomed Res Int 2019 4;2019:6932047. Epub 2019 Mar 4.

Division of Phoniatrics, ENT University Hospital Graz, Medical University Graz, Auenbruggerplatz 26, Graz 8036, Austria.

It is well known that the phonatory process changes during the life span. However, detailed investigations on potential factors concerned are rare. To deal with this issue, we performed extended biomechanical, macro anatomical, and histological analyses of the contributing laryngeal structures in ex vivo juvenile sheep models. Read More

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http://dx.doi.org/10.1155/2019/6932047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425324PMC

A Modified Anteromedial Approach for Exposure of Coronoid Fractures: An Anatomical Cadaver Study.

Biomed Res Int 2019 4;2019:6872948. Epub 2019 Mar 4.

Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.

The previous anterior approach to the elbow provides a limited exposure of the coronoid process. The aim of this study was to identify the optimal exposure interval for coronoid fractures from the anterior aspect of elbow. We exposed the coronoid process on twelve fresh-frozen cadaveric elbows from the anteromedial aspect of the elbow. Read More

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https://www.hindawi.com/journals/bmri/2019/6872948/
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http://dx.doi.org/10.1155/2019/6872948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425352PMC
March 2019
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Minocycline Protects against Rotenone-Induced Neurotoxicity Correlating with Upregulation of Nurr1 in a Parkinson's Disease Rat Model.

Biomed Res Int 2019 5;2019:6843265. Epub 2019 Mar 5.

Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China.

The aim of this study was to investigate the effect of minocycline in rats with rotenone-induced Parkinson's disease (PD). The open field test was performed to determine the motor ability of the rats. Double immunofluorescence staining was used to detect the expression of tyrosine hydroxylase (TH) and Nurr1 in the substantia nigra (SN) of rats. Read More

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http://dx.doi.org/10.1155/2019/6843265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425343PMC

Effects of Different Thickness Combinations of Core and Veneer Ceramics on Optical Properties of CAD-CAM Glass-Ceramics.

Biomed Res Int 2019 4;2019:5856482. Epub 2019 Mar 4.

Department of Dental Laboratory Science and Engineering, College of Health Science, Korea University, Seoul, Republic of Korea.

The goal of this study was to evaluate the effects of different core and veneer thicknesses on the translucency (T%), average light transmittance (T), translucency parameter (TP), contrast ratio (CR), and spectral reflectance (R) of glass-ceramics using a computer-aided design/computer-aided manufacturing (CAD-CAM) process. In all, 42 specimens (11mm × 11mm) were prepared and divided into six groups ( = 7 for each group). Core materials (IPS e. Read More

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https://www.hindawi.com/journals/bmri/2019/5856482/
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http://dx.doi.org/10.1155/2019/5856482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425410PMC
March 2019
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Long Noncoding RNA ASB16-AS1 Promotes Proliferation, Migration, and Invasion in Glioma Cells.

Biomed Res Int 2019 4;2019:5437531. Epub 2019 Mar 4.

Department of Neurosurgery, Shenzhen Hospital, Southern Medical University, 1333 Xinhu Road, Shenzhen 518100, Guangdong, China.

Glioma is a lethal, malignant intracranial tumor that becomes progressively common. It has been shown that long noncoding RNAs (lncRNAs) serve important roles in numerous diseases such as gliomas. lncRNAs can regulate the expression of targeted genes through various mechanisms. Read More

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http://dx.doi.org/10.1155/2019/5437531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425370PMC

Diagnosis of Parapneumonia Pleural Effusion with Serum and Pleural Fluid Cell-Free DNA.

Biomed Res Int 2019 4;2019:5028512. Epub 2019 Mar 4.

Department of Biological Science, National Sun Yat-Sen University, Kaohsiung, Taiwan.

Objective: As cell-free DNA levels in the pleural fluid and serum of parapneumonic pleural effusion (PPE) patients have not been thoroughly explored, we evaluated their diagnostic potential.

Methods: Twenty-two PPE and 16 non-PPE patients were evaluated. Serum and pleural fluids were collected, and cell-free DNA was quantified. Read More

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https://www.hindawi.com/journals/bmri/2019/5028512/
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http://dx.doi.org/10.1155/2019/5028512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425321PMC
March 2019
2 Reads

Rapid Enkephalin Delivery Using Exosomes to Promote Neurons Recovery in Ischemic Stroke by Inhibiting Neuronal p53/Caspase-3.

Biomed Res Int 2019 4;2019:4273290. Epub 2019 Mar 4.

The Department of Rehabilitation, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China.

No pharmacological treatment is currently available to protect brain from neuronal damage after ischemic stroke. Recent studies found that enkephalin may play an important role in neuron regeneration. We assembled a homogeneous size vesicle constituted by transferrin, exosomes, and enkephalin. Read More

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https://www.hindawi.com/journals/bmri/2019/4273290/
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http://dx.doi.org/10.1155/2019/4273290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425296PMC
March 2019
2 Reads