261 results match your criteria BioImpacts : BI[Journal]


In vitro study of the anticancer activity of various doxorubicin-containing dispersions.

Bioimpacts 2019 14;9(1):57-63. Epub 2018 Oct 14.

Technical University Ilmenau, Institute of Chemistry and Biotechnology, Weimarer Str., 25, 98693 Ilmenau, Germany.

The aim of this research was to study the impact of various doxorubicin (Dox)-containing nanofluids, e.g. singlewalled carbon nanotube (SWCNT)+Dox, graphene oxide (GO)+Dox and DextranPNIPAM (copolymer)+Dox mixtures on HeLa cells (human transformed cervix epithelial cells, as a model for cancer cells) depending on their concentration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2019.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378100PMC
October 2018
1 Read

design of a triple-negative breast cancer vaccine by targeting cancer testis antigens.

Bioimpacts 2019 2;9(1):45-56. Epub 2018 Jul 2.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Triple-negative breast cancer (TNBC) is an important subtype of breast cancer, which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to the recent studies, TNBC may be a cancer testis antigen (CTA)-positive tumor, indicating that the CTA-based cancer vaccine can be a treatment option for the patients bearing such tumors. Of these antigens (Ags), the MAGE-A family and NY-ESO-1 as the most immunogenic CTAs are the potentially relevant targets for the development of an immunotherapeutic way of the breast cancer treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2019.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378095PMC

Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin.

Bioimpacts 2019 7;9(1):37-43. Epub 2018 Oct 7.

Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Rajpura-140401, Patiala, Punjab, India.

Skin can be used as a site for local and systemic drug administration. Diffusion of drugs through the skin has led to the development of different transdermal drug delivery systems. Curcumin is a wound healing and anti-inflammatory agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2019.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378101PMC
October 2018

and evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent.

Bioimpacts 2019 2;9(1):25-36. Epub 2018 Oct 2.

INSERM, UMR_S1148, Laboratory for Vascular Translational Sciences, Hôpital Bichat.

The major complications of stent implantation are restenosis and late stent thrombosis. PBMA polymers are used for stent coating because of their mechanical properties. We previously synthesized and characterized Dextrangraft-polybutylmethacrylate copolymer (Dex-PBMA) as a potential stent coating. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2019.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378099PMC
October 2018
1 Read

Highly efficient novel recombinant L-asparaginase with no glutaminase activity from a new halo-thermotolerant strain.

Bioimpacts 2019 13;9(1):15-23. Epub 2018 Sep 13.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The bacterial enzyme has gained more attention in therapeutic application because of the higher substrate specificity and longer half-life. L-asparaginase is an important enzyme with known antineoplastic effect against acute lymphoblastic leukemia (ALL). Novel L-asparaginase genes were identified from a locally isolated halo-thermotolerant strain and the recombinant enzymes were overexpressed in modified strains, Origami B and BL21. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2019.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378094PMC
September 2018
1 Read

Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent.

Bioimpacts 2019 18;9(1):5-13. Epub 2018 Jul 18.

Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.

In recent years, more attention was dedicated to developing new methods for designing of drug delivery systems. The aim of present work is to improve the efficiency of the antibacterial drug delivery process, and to realize and to control accurately the release. First, graphene oxide (GO) was prepared according to the modified Hummers method then the GO was modified with carboxymethylcellulose (CMC) and Zn-based metal-organic framework (MOF-5) through the solvothermal technique. Read More

View Article

Download full-text PDF

Source
https://bi.tbzmed.ac.ir/Abstract/bi-17635
Publisher Site
http://dx.doi.org/10.15171/bi.2019.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378098PMC
July 2018
5 Reads

Indoleamine 2, 3-dioxygenase inhibitors in immunochemotherapy of breast cancer: challenges and opportunities.

Bioimpacts 2019 21;9(1):1-3. Epub 2018 Oct 21.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Trafficking of macromolecular immunotherapy agent into the tumor microenvironment (TME) is a challenging issue. In the TME, cancer cells exploit indoleamine 2, 3-dioxygenase (IDO), as a cytosolic enzyme that catalyzes the L-tryptophan (Trp) through the kynurenine (Kyn) pathway, which could negatively regulate the activity of T cells. Thus, Trp/Kyn pathway, can be targeted with novel treatment modalities such as IDO1 inhibitor to benefit patients with aggressive solid tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2019.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378097PMC
October 2018

Retraction Note: Inhibition of hTERT Gene Expression by SilibininLoaded PLGA-PEG-Fe₃O₄ in T47D Breast Cancer Cell Line.

Bioimpacts 2018 16;8(4):321. Epub 2018 Sep 16.

Faculty of Advanced Medical Sciences, Department of Medical Biotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.

[This retracts the article DOI: 10.5681/bi.2013. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-19682
Publisher Site
http://dx.doi.org/10.15171/bi.2018.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209827PMC
September 2018
18 Reads

Recent advances in improving oral drug bioavailability by cocrystals.

Bioimpacts 2018 31;8(4):305-320. Epub 2018 May 31.

Biotechnology Research Center, and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy. Improving oral absorption of drugs with low water solubility and/or low intestinal membrane permeability is an active field of research. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-17553
Publisher Site
http://dx.doi.org/10.15171/bi.2018.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209825PMC
May 2018
16 Reads

An fMRI investigation of the neural correlates underlying the autonomous sensory meridian response (ASMR).

Bioimpacts 2018 23;8(4):295-304. Epub 2018 Sep 23.

Center for Cognitive Neuroscience, Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.

: The "autonomous sensory meridian response" (ASMR) is a neologism used to describe an internal sensation of deep relaxation and pleasant head tingling which is often stimulated by gentle sounds, light touch, and personal attention. : An fMRI-based methodology was employed to examine the brain activation of subjects prescreened for ASMR-receptivity (n=10) as they watched ASMR videos and identified specific moments of relaxation and tingling. : Subjects who experienced ASMR showed significant activation in regions associated with both reward (NAcc) and emotional arousal (dACC and Insula/IFG). Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-17613
Publisher Site
http://dx.doi.org/10.15171/bi.2018.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209833PMC
September 2018
8 Reads

Comparative in vitro/theoretical studies on the anti-angiogenic activity of date pollen hydro-alcoholic extract: Highlighting the important roles of its hot polyphenols.

Bioimpacts 2018 14;8(4):281-294. Epub 2018 Jun 14.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Date palm pollen (DPP) is the male reproductive soft powder from date flowers widely used as the valuable dietary supplement to fortify the size of testis and ovarian to increase the power of sex. This part of date palm significantly exhibited anti-diabetic, anti-inflammation and protective effects against male and female infertility. Though the anticancer activity of date fruits was previously reported, the DPP anti-angiogenic effects were not reported, and as the first study, its inhibitory effects were examined in the current study. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-17576
Publisher Site
http://dx.doi.org/10.15171/bi.2018.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209826PMC
June 2018
23 Reads

Numerical study on the impulsive growth of a gaseous plug inside a cylindrical vein with compliant coating.

Bioimpacts 2018 18;8(4):271-279. Epub 2017 Sep 18.

School of Mechanical Engineering, University of Tabriz, Tabriz, Iran.

: Employing of gaseous plugs inside a vein for preventing of blood flow to the damaged or cancerous tissues has been known as a gas embolism in the medicine. In this research, a numerical investigation has been carried out on the delivery of the liquid drug DDFP, encapsulated in the microlipidcoated spheres (MLCSs), to target the human vein for construction of the gaseous plug inside the veins. : The encapsulated liquid drug DDFP were delivered to the vein by injection of an emulsion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209829PMC
September 2017

Nafion-coated cadmium pentacyanonitrosylferrate-modified glassy carbon electrode for detection of dopamine in biological samples.

Bioimpacts 2018 30;8(4):263-270. Epub 2017 Aug 30.

Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

: Dopamine is one of the key neurotransmitters (NTs) in nature, which plays a crucial role in the mammalian central nervous system (CNS). Its selective determination in the biological fluids is an essential need in the field of biomedicine studies. : In this work, an amperometric sensor was developed using Nafion-coated cadmium pentacyanonitrosylferrate (CdPCNF) modified glassy carbon (GC) electrode (Nafion|CdPCNF|GC electrode) as an electrocatalyst to detect dopamine (DA) in human serum samples. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/BI_233_20141026135911
Publisher Site
http://dx.doi.org/10.15171/bi.2018.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209831PMC
August 2017
21 Reads

Characterization and partial purification of an antibacterial agent from halophilic actinomycetes . strain rsk4.

Bioimpacts 2018 1;8(4):253-261. Epub 2018 May 1.

Department of Microbiology, Shree M. & N. Virani Science College, Kalawad Road, Rajkot 360005, Gujarat, India.

: The inevitable rise of antibiotic-resistant bacteria is a global health problem. These pathogens erode the utility of available antibiotics. is one of the major causes of community-acquired infections. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-17572
Publisher Site
http://dx.doi.org/10.15171/bi.2018.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209832PMC
May 2018
12 Reads

Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma.

Bioimpacts 2018 18;8(4):241-252. Epub 2018 Apr 18.

Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz 71345, Iran.

Sorafenib (SFB) is an FDA-approved chemotherapeutic agent with a high partition coefficient (log P = 4.34) for monotherapy of hepatocellular carcinoma (HCC). The oral bioavailability is low and variable, so it was aimed to study the application of the polymeric nanoassembly of cholesterol conjugates of branched polyethyleneimine (PEI) for micellar solubilization of SFB and to investigate the impact of the polymer PEGylation on the physicochemical and cellular characteristics of the lipopolymeric dispersions. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-17546
Publisher Site
http://dx.doi.org/10.15171/bi.2018.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209830PMC
April 2018
11 Reads

Microfluidic paper-based analytical devices (µPADs) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases.

Bioimpacts 2018 2;8(4):237-240. Epub 2018 Jul 2.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Through the development of analytical techniques, microscaled devices have displayed attractive advantages, including ultrasensitive detection and analysis, cost-effectiveness, portability, process integrity, multi-process functionality, and in-situ analysis. In the last decade, a new generation of analytical devices has emerged based on the cellulose materials - so-called microfluidic paper-based analytical devices (µPADs) - a field that will change the face of the diagnosis of different diseases and sensing of a wide range of biological/chemical/biochemical phenomena. The main aim of the current editorial is to highlight the importance of the µPADs in the research and development of diagnostic devices and pharmaceuticals. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-17630
Publisher Site
http://dx.doi.org/10.15171/bi.2018.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209828PMC
July 2018
3 Reads

Breast cancer vaccination comes to age: impacts of bioinformatics.

Bioimpacts 2018 18;8(3):223-235. Epub 2018 Apr 18.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Breast cancer, as one of the major causes of cancer death among women, is the central focus of this study. The recent advances in the development and application of computational tools and bioinformatics in the field of immunotherapy of malignancies such as breast cancer have emerged the new dominion of immunoinformatics, and therefore, next generation of immunomedicines . Having reviewed the most recent works on the applications of computational tools, we provide comprehensive insights into the breast cancer incidence and its leading causes as well as immunotherapy approaches and the future trends. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128970PMC
April 2018
41 Reads

A cancer vaccine with dendritic cells differentiated with GM-CSF and IFNα and pulsed with a squaric acid treated cell lysate improves T cell priming and tumor growth control in a mouse model.

Bioimpacts 2018 10;8(3):211-221. Epub 2018 Jun 10.

Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, USA.

Ovarian cancer is one of the most lethal gynecologic cancers. Relapses after remission are common, hence novel strategies are urgently needed. Our group has previously developed a vaccination approach based on dendritic cells pulsed with HOCl-oxidized tumor lysates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128972PMC
June 2018
6 Reads

In silico identification of albendazole as a quorum sensing inhibitor and its in vitro verification using CviR and LasB receptors based assay systems.

Bioimpacts 2018 23;8(3):201-209. Epub 2018 Mar 23.

Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences (SIHAS), Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS), Allahabad, Uttar-Pradesh-211007, India.

Quorum sensing inhibition (QSI) is one of the vital tools to overcome emerging virulence of pathogenic bacteria which aims at curbing bacterial resistance. Targeting QS (quorum sensing) as chemotherapy is less likely to generate resistance among pathogens as it targets only the adaptation and not the survival mechanism of the pathogen. Several QS inhibitors were developed in the recent past but none of them managed to have clinical application due to known toxic effects for human consumption. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128976PMC
March 2018
15 Reads

Numerical investigation of the blood flow through the middle cerebral artery.

Bioimpacts 2018 10;8(3):195-200. Epub 2018 May 10.

Department of Mechanical Engineering, Faculty of Mechanical Engineering, University of Tabriz, Tabriz, Iran.

The middle cerebral artery (MCA) is one of the three major paired arteries that supply the blood to the cerebrum. In the present study, the three-dimensional (3D) blood flow in the left MCA was numerically simulated by using the medical imaging. The arterial geometry was obtained by applying the CT angiography of the MCA of a 75-year-old man. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128971PMC
May 2018
2 Reads

Gallic acid and curcumin induce cytotoxicity and apoptosis in human breast cancer cell MDA-MB-231.

Bioimpacts 2018 5;8(3):185-194. Epub 2018 Mar 5.

Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.

Gallic acid (GA) and curcumin (Cur) are natural phenolic compounds that their anti-tumor effects on many types of cancers have been proved. In the current study, the effect of the combination of these agents on MDA-MB-231 breast cancer cells was investigated. Inhibition of cell proliferation (MTT assay), light microscopy, fluorescence microscopy, cell cycle analysis, nitrite detection, ROS levels, measurement of the mitochondrial membrane potential, GSH level, Annexin V assay, RT-PCR and Western blotting methods were applied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128975PMC
March 2018
10 Reads

Altered levels of immune-regulatory microRNAs in plasma samples of patients with lupus nephritis.

Bioimpacts 2018 14;8(3):177-183. Epub 2018 Apr 14.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Lupus nephritis (LN) is a major cause of mortality and morbidity in the patients with lupus, a chronic autoimmune disease. The role of genetic and epigenetic factors is emphasized in the pathogenesis of LN. The aim of the present study was to evaluate the levels of immune-regulatory microRNAs (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128973PMC
April 2018
1 Read

Expression, purification and DNA-binding properties of zinc finger domains of DOF proteins from .

Bioimpacts 2018 28;8(3):167-176. Epub 2018 Jan 28.

School of Life and Environmental Sciences, The University of Sydney, NSW 2006, Australia.

DOF proteins are a family of plant-specific transcription factors with a conserved zinc finger (ZF) DNA-binding domain. Although several studies have demonstrated their specific DNA binding, quantitative affinity data is not available for the binding of DOF domains to their binding sites. ZF domains of DOF2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128974PMC
January 2018
2 Reads

Risk association, linkage disequilibrium and haplotype analyses of rs4246445, rs2229425, rs2228305 and rs2229422 polymorphisms in overweight and obesity.

Bioimpacts 2018 29;8(3):159-165. Epub 2017 Dec 29.

Biotechnology Programme, Faculty of Science and Natural Resources, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia.

Obesity is commonly linked up with several life-threatening diseases. This study aims to investigate the association of fatty acid synthase () rs4246445, rs2229425, rs2228305, and rs2229422 single nucleotide polymorphisms (SNPs) with the risk of overweight and obesity in the Malaysian population. Blood samples were collected from 1030 individuals who were grouped into normal, overweight, and obese categories. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128978PMC
December 2017

Enzyme replacement therapies: what is the best option?

Bioimpacts 2018 7;8(3):153-157. Epub 2018 Jul 7.

Department of Neurology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvanian 19107, USA.

Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the infused enzyme and development of resistance to enzymes persist. These issues may limit the desired therapeutic outcomes of a majority of the lysosomal storage diseases (LSDs). Furthermore, the biodistribution of the recombinant enzymes into the target cells within the central nervous system (CNS), bone, cartilage, cornea, and heart still remain unresolved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128977PMC
July 2018
4 Reads

An update of the recombinant protein expression systems of Cyanovirin-N and challenges of preclinical development.

Bioimpacts 2018 16;8(2):139-151. Epub 2017 Nov 16.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Human immunodeficiency virus (HIV) is a debilitating challenge and concern worldwide. Accessibility to highly active antiretroviral drugs is little or none for developing countries. Production of cost-effective microbicides to prevent the infection with HIV is a requirement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026528PMC
November 2017
16 Reads

Reprogramming of mouse fibroblasts into neural lineage cells using biomaterials.

Bioimpacts 2018 10;8(2):129-138. Epub 2018 Jan 10.

Laboratory of Biomedical and Biophysical Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, Japan.

Induced neural stem cells (iNSCs) have the ability of differentiation into neurons, astrocytes and oligodendrocytes. iNSCs are very useful in terms of research and treatment. The present study offers an idea that biomaterials could be one of the tools that could modulate reprogramming process in the fibroblasts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026523PMC
January 2018
16 Reads

Mucin-1 aptamer-armed superparamagnetic iron oxide nanoparticles for targeted delivery of doxorubicin to breast cancer cells.

Bioimpacts 2018 5;8(2):117-127. Epub 2018 May 5.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Superparamagnetic iron oxide nanoparticles (SPIONs) can be functionalized with various agents (e.g., targeting and therapeutic agents) and used for targeted imaging/therapy of cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026525PMC
May 2018
5 Reads

The assessment of metabolite alteration induced by -OH functionalized multi-walled carbon nanotubes in mice using NMR-based metabonomics.

Bioimpacts 2018 6;8(2):107-116. Epub 2017 Dec 6.

Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.

There is a fundamental need to characterize multiwalled carbon nanotubes (MWCNTs) toxicity to guarantee their safe application. Functionalized MWCNTs have recently attracted special interest in order to enhance biocompatibility. The aim of the current work was to study the underlying toxicity mechanism of the -OH-functionalized MWCNTs (MWCNTs-OH), using the powerful NMR-based metabonomics technique. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026527PMC
December 2017
5 Reads

Drug nanocarrier agents based on starch-g-amino acids.

Bioimpacts 2018 28;8(2):99-106. Epub 2017 Nov 28.

Laboratory of Dendrimers and Biopolymers, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.

In the recent decades, starch has been modified using different methods for the various forms of applications. Some new starch derivatives were prepared through a simple and convenient method in the grafting of amino acids: L-alanine, L-leucine and L-phenyl alanine to starch. First, the amine groups of amino acids were protected using phthalic anhydride then the acidic side of amino acids were activated with chlorination using thionyl chloride, and the resultant acid chlorides were reacted with starch in aqueous media at room temperature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026521PMC
November 2017
1 Read

Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases.

Bioimpacts 2018 14;8(2):91-98. Epub 2017 Jan 14.

INRA, UR1268 Biopolymères Interactions Assemblages, Rue de la Géraudière, Nantes, 44316, France.

Starch-based materials were designed using a special extrusion die in order to obtain a tube-shaped device for application to salivary duct treatment in the field of endoscopy, i.e., sialendoscopy . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026526PMC
January 2017

Biosynthesis of TiO and ZnO nanoparticles by IBRC-M 10214 in different conditions of medium.

Bioimpacts 2018 27;8(2):81-89. Epub 2017 Dec 27.

Microbiology Laboratory, Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran.

In the recent years, green synthesis is a novel method without some disadvantages of physical and chemical methods. In this approach, bacteria, archaebacteria, fungi, and plants may be applied without utilizing toxic and expensive materials for metal nanoparticles (MNPs) preparation. In this study, we used Taguchi method to obtain optimum conditions in titanium dioxide and zinc oxide nanoparticle (NPs) biosynthesis by IBRC-M 10214. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-17439
Publisher Site
http://dx.doi.org/10.15171/bi.2018.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026522PMC
December 2017
11 Reads

Made-on-demand, complex and personalized 3D-printed drug products.

Bioimpacts 2018 10;8(2):77-79. Epub 2018 Mar 10.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Layer-by-layer fabrication of three dimensional (3D) objects from digital models is called 3D printing. This technology established just about three decades ago at the confluence of materials science, chemistry, robotics, and optics researches to ease the fabrication of UV-cured resin prototypes. The 3D technology was rapidly considered as a standard instrument in the aerospace, automotive, and consumer goods production factories. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026524PMC
March 2018
2 Reads

Combating atherosclerosis with targeted nanomedicines: recent advances and future prospective.

Bioimpacts 2018 25;8(1):59-75. Epub 2018 Feb 25.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Cardiovascular diseases (CVDs) is recognized as the leading cause of mortality worldwide. The increasing prevalence of such disease demands novel therapeutic and diagnostic approaches to overcome associated clinical/social issues. Recent advances in nanotechnology and biological sciences have provided intriguing insights to employ targeted Nanomachines to the desired location as imaging, diagnosis, and therapeutic modalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915710PMC
February 2018
1 Read

Chemiluminescence based immunoassay for the detection of heroin and its metabolites.

Bioimpacts 2018 30;8(1):53-58. Epub 2017 Oct 30.

Amity Institute of Biotechnology, Amity University, Sector-125, Noida-201313, India.

Continuous use of opiates causes drug-related illnesses, which poses an alarming situation to develop sensitive detection platform. In this study, a highly sensitive and reliable chemiluminescence immunoassay (CI) has been developed for the detection of heroin and its major metabolites in spiked urine samples. To develop robust immunoassay, monoacetyl morphine-bovine serum albumin (MAM-BSA) conjugate was synthesized and characterized thoroughly by physicochemical techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915709PMC
October 2017
8 Reads

A novel B- and helper T-cell epitopes-based prophylactic vaccine against .

Bioimpacts 2018 20;8(1):39-52. Epub 2017 Dec 20.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

In this study, we targeted the worm stage of to design a novel multi-epitope B- and helper T-cell based vaccine construct for immunization of dogs against this multi-host parasite. The vaccine was designed based on the local Eg14-3-3 antigen (Ag). DNA samples were extracted from the protoscoleces of the infected sheep's liver, and then subjected to the polymerase chain reaction (PCR) with 14-3-3 specific forward and reverse primers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915707PMC
December 2017
2 Reads

Spectrophotometric analysis of thrombolytic activity: SATA assay.

Bioimpacts 2018 1;8(1):31-38. Epub 2017 Nov 1.

Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.

Measurement of thrombolytic activity is crucial for research and development of novel thrombolytics. It is a key factor in the assessment of the effectiveness of conventionally used thrombolytic therapies in the clinic. Previous methods used for the assessment of thrombolytic activity are often associated with some drawbacks such as being costly, time-consuming, complex with low accuracy. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-17473
Publisher Site
http://dx.doi.org/10.15171/bi.2018.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915706PMC
November 2017
7 Reads

Haw. protects liver against paracetamol toxicity and inhibits CYP2E1.

Bioimpacts 2018 30;8(1):23-30. Epub 2017 Oct 30.

Nizam Institute of Pharmacy, Nalgonda, India.

Paracetamol is a potent hepatotoxin and may cause severe acute hepatocellular injury. The present study was intended to assess the hepatoprotective potential of Haw. (Asclepiadaceae) ( ) against paracetamol-induced hepatotoxicity and experimental models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915705PMC
October 2017
3 Reads

Development of a new sequential block finding strategy for detection of conserved sequences in riboswitches.

Bioimpacts 2018 30;8(1):13-22. Epub 2017 Aug 30.

Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Some non-coding RNAs have an important role in the regulation of gene expression and consequently cellular function. Riboswitches are examples of these regulatory RNAs. Riboswitches are classified into various families according to sequential and structural similarities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915704PMC
August 2017
5 Reads

The role of PRP and adipose tissue-derived keratinocytes on burn wound healing in diabetic rats.

Bioimpacts 2018 18;8(1):5-12. Epub 2017 Nov 18.

Department of Medical Biochemistry, Faculty of Medicine, Ege University, Izmir, 35100, Turkey.

Diabetic burn wounds and ulcers are significant complications of diabetic patients. The aim of this study is to investigate the use of platelet rich-plasma (PRP) and/or keratinocyte-like cells (KLCs) in diabetic thermal wound rat model and to evaluate EGF, FGF-2, TGF-β1, COL1α2, MCP-1 and VEGF-α as wound healing markers at gene expression level. In this study, we used adipose tissue as the source of mesenchymal stem cells (MSCs) and differentiated MSCs into KLCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915708PMC
November 2017
1 Read

Bacterial NanoCellulose: what future?

Bioimpacts 2018 15;8(1):1-3. Epub 2017 Dec 15.

Centre of Biological Engineering, University of Minho, Campus de Gualtar 4710-057 Braga, Portugal.

Acetic acid bacteria (AAB) have been used in various fermentation processes. Of several ABB, the bacterial nanocellulose (BNC) producers, notably , appears as an interesting species, in large part because of their ability in the secretion of cellulose as nano/microfibrils. In fact, BNC is characterized by a native nanofibrillar structure, which may outperform the currently used celluloses in the food industry as a promising novel hydrocolloid additive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2018.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915703PMC
December 2017
5 Reads

Stimuli-responsive chitosan-based nanocarriers for cancer therapy.

Bioimpacts 2017 15;7(4):269-277. Epub 2017 Nov 15.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Stimuli-responsive nanocarriers offer unique advantages over the traditional drug delivery systems (DDSs) in terms of targeted drug delivery and on-demand release of cargo drug molecules. Of these, chitosan (CS)-based DDSs offer several advantages such as high compatibility with biological settings. In this study, we surveyed the literature in terms of the stimuli-responsive nanocarriers and discussed the most recent advancements in terms of CS-based nanosystems and their applications in cancer therapy and diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2017.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801539PMC
November 2017
4 Reads

The study of association between reduced folate carrier 1 () polymorphism and non-syndromic cleft lip/palate in Iranian population.

Bioimpacts 2017 28;7(4):263-268. Epub 2017 Nov 28.

Genetic Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Cleft lip/palate is one of the most common congenital defects and is supposed to have multifactorial etiology, including a complex interaction between genetics and environment. Reduced folate carrier 1 () gene takes part in folate transportation within the cells. In this study, the association of A80G polymorphism in the gene with the non-syndromic cleft lip/palate (nsCL/P) was investigated in Iranian infants for the first time. Read More

View Article

Download full-text PDF

Source
http://bi.tbzmed.ac.ir/Abstract/bi-17510
Publisher Site
http://dx.doi.org/10.15171/bi.2017.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801538PMC
November 2017
12 Reads

Association of glutathione S-transferase polymorphisms with the severity of mustard lung.

Bioimpacts 2017 30;7(4):255-261. Epub 2017 Aug 30.

Immunoregulation Research Center, Shahed University, Tehran, Iran.

Glutathione S-transferase (GST) is one of the major detoxifiers in alveoli. Polymorphism in GST genes can influence the ability of individuals to suppress oxidative stress and inflammation. The present study was aimed to explore the hypothesis that the genetic polymorphisms of GST , and are associated with the severity of the mustard lung in the sulfur mustard-exposed individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2017.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801537PMC
August 2017
2 Reads

Efficient and stable transformation of by 3 strains of .

Bioimpacts 2017 18;7(4):247-254. Epub 2017 Sep 18.

Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran.

Several platforms including mammalian, plant and insect cells as well as bacteria, yeasts, and microalgae are available for the production of recombinant proteins. Low efficiency of delivery systems, extracellular and intracellular degradation of foreign genes during transformation, difficulties in targeting and importing into the nucleus, and finally problems in integration into nuclear genome are the most bottlenecks of classical plasmids for producing recombinant proteins. Owing to high growth rate, no common pathogen with humans, being utilized as humans' food, and capability to perform N-glycosylation, microalgae are proposed as an ideal system for such biotechnological approaches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2017.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801536PMC
September 2017
4 Reads

Spectroscopic, thermodynamic and molecular docking studies of bovine serum albumin interaction with ascorbyl palmitate food additive.

Bioimpacts 2017 30;7(4):241-246. Epub 2017 Aug 30.

Nutrition Research Center, Department of Food Science and Technology, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

Ascorbyl palmitate (AP) is an example of natural secondary food antioxidant, which has been used for oxidative rancidity prevention in food industry. In this study, the interaction of AP with bovine serum albumin (BSA) was investigated. The mechanism of BSA interaction with AP was investigated using spectroscopic methods (UV-Vis, fluorescence). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2017.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801535PMC
August 2017
6 Reads

Development and evaluation of exemestane-loaded lyotropic liquid crystalline gel formulations.

Bioimpacts 2017 3;7(4):227-239. Epub 2017 Sep 3.

PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan BE 1410, Brunei Darussalam.

The use of liquid crystalline (LC) gel formulations for drug delivery has considerably improved the current delivery methods in terms of bioavailability and efficacy. The purpose of this study was to develop and evaluate LC gel formulations to deliver the anti-cancer drug exemestane through transdermal route. Two LC gel formulations were prepared by phase separation coacervation method using glyceryl monooleate (GMO), Tween 80 and Pluronic® F127 (F127). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2017.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801534PMC
September 2017
10 Reads

Effect of hydroxychloroquine on oxidative/nitrosative status and angiogenesis in endothelial cells under high glucose condition.

Bioimpacts 2017 23;7(4):219-226. Epub 2017 Aug 23.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Under the diabetic condition, sustained production of oxidative/nitrosative stress results in irreversible vascular injuries. A great number of diabetic pathologies, such as inefficient or aberrant neo-angiogenesis emerge following chronic hyperglycemic condition. Lack of enough data exists regarding hydroxychloroquine (HCQ) contribution on angiogenesis during diabetes mellitus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2017.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801533PMC
August 2017
3 Reads

Study-based registers of randomized controlled trials: Starting a systematic review with data extraction or meta-analysis.

Bioimpacts 2017 17;7(4):209-217. Epub 2017 Sep 17.

Cochrane Schizophrenia Group, the Institute of Mental Health, a partnership between the University of Nottingham and Nottinghamshire Healthcare NHS Trust, Nottingham, United Kingdom.

Despite years of use of study-based registers for storing reports of randomized controlled trials (RCTs), the methodology used in developing such registers/databases has not been documented. Such registers are integral to the process of scientific reviewing. We document and discuss methodological aspects of the development and use of study-based registers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15171/bi.2017.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801532PMC
September 2017
2 Reads