299 results match your criteria BioImpacts : BI[Journal]


Proteomic profiling of by high-resolution mass spectrometry.

Bioimpacts 2020 26;10(2):123-135. Epub 2020 Mar 26.

Institute of Bioinformatics, International Technology Park, Bangalore-560066, Karnataka, India.

an opportunistic human pathogen, is reported as an important cause of nosocomial infection and outbreaks. Although the genome of (ATCC 13880) was completely sequenced by 2014, there are no studies on the proteomic profile of the organism. The objective of the present study is to analyze the protein profile of (ATCC 13880) using a high resolution mass spectrometry (MS). Read More

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http://dx.doi.org/10.34172/bi.2020.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186543PMC

Placenta mesenchymal stem cells differentiation toward neuronal-like cells on nanofibrous scaffold.

Bioimpacts 2020 26;10(2):117-122. Epub 2020 Mar 26.

Department of Obstetrics and Gynecology, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.

Transplantation of stem cells with a nanofibrous scaffold is a promising approach for spinal cord injury therapy. The aim of this work was to differentiate neural-like cells from placenta-derived mesenchymal stem cells (PDMSCs) using suitable induction reagents in three (3D) and two dimensional (2D) culture systems. After isolation and characterization of PDMSCs, the cells were cultivated on poly-L-lactide acid (PLLA)/poly caprolactone (PCL) nanofibrous scaffold and treated with a neuronal medium for 7 days. Read More

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http://dx.doi.org/10.34172/bi.2020.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186541PMC

Conditions for combining gene therapy with bone marrow transplantation in murine Krabbe disease.

Bioimpacts 2020 24;10(2):105-115. Epub 2020 Mar 24.

Department of Neurology, Sidney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Krabbe disease (KD) is an autosomal recessive lysosomal disorder caused by mutations in the galactocerebrosidase (GALC) gene. This results in defective myelination in the peripheral and central nervous systems due to low GALC activity. Treatment at this time is limited to hematopoietic stem cell transplantation (HSCT) in pre-symptomatic individuals. Read More

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http://dx.doi.org/10.34172/bi.2020.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186542PMC

Identification and ranking of important bio-elements in drug-drug interaction by Market Basket Analysis.

Bioimpacts 2020 2;10(2):97-104. Epub 2019 Nov 2.

Department of Health Care Management, Tehran University of Medical Sciences, Tehran, Iran.

Drug-drug interactions (DDIs) are the main causes of the adverse drug reactions and the nature of the functional and molecular complexity of drugs behavior in the human body make DDIs hard to prevent and threat. With the aid of new technologies derived from mathematical and computational science, the DDI problems can be addressed with a minimum cost and effort. The Market Basket Analysis (MBA) is known as a powerful method for the identification of co-occurrence of matters for the discovery of patterns and the frequency of the elements involved. Read More

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http://dx.doi.org/10.34172/bi.2020.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186546PMC
November 2019

Poly(ethylene glycol)-poly(ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibinin.

Bioimpacts 2020 2;10(2):87-95. Epub 2019 Nov 2.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Silibinin is a naturally occurring compound with known positive impacts on prevention and treatment of many types of in general and cancer in particular. Silibinin is poorly water soluble which results in its insufficient bioavailability and lack of therapeutic efficacy in cancer. Here, we proposed to examine the potential of micelles composed of poly(ethylene glycol) (PEG) as the hydrophilic block and poly(ε-caprolactone) (PCL), poly(α-benzylcarboxylate-ε-caprolactone) (PBCL), or poly(lactide)-(PBCL) (PLA-PBCL) as hydrophobic blocks for enhancing the water solubility of silibinin and its targeted delivery to tumor. Read More

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http://dx.doi.org/10.34172/bi.2020.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186544PMC
November 2019

Freeze-dried multiscale porous nanofibrous three dimensional scaffolds for bone regenerations.

Bioimpacts 2020 8;10(2):73-85. Epub 2020 Feb 8.

Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Simulating hydrophobic-hydrophilic composite face with hierarchical porous and fibrous architectures of bone extracellular matrix (ECM) is a key aspect in bone tissue engineering. This study focused on the fabrication of new three-dimensional (3D) scaffolds containing polytetrafluoroethylene (PTFE), and polyvinyl alcohol (PVA), with and without graphene oxide (GO) nanoparticles using the chemical cross-linking and freeze-drying methods for bone tissue application. The effects of GO on physicochemical features and osteoinduction properties of the scaffolds were evaluated through an in vitro study. Read More

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http://dx.doi.org/10.34172/bi.2020.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186540PMC
February 2020

induces apoptosis in gastric cancer cells via modulation of signaling pathways in .

Bioimpacts 2020 28;10(2):65-72. Epub 2019 Jun 28.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Gastric cancer is considered the second prevalent cause of death around the world. This type of cancer is generally induced by which could colonize within the gastric mucosa of the infected cases. To date, triple antibiotic therapy has routinely been utilized for controlling the induced infection. Read More

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http://dx.doi.org/10.34172/bi.2020.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186545PMC

The absence of legal remedies following academic bullying.

Bioimpacts 2020 28;10(2):63-64. Epub 2019 Nov 28.

School of Business, Wake Forest University, NC, USA.

Currently, victims of discrimination and sexual harassment have institutional reporting systems and legal remedies which support them in finding justice for these crimes. However, victims of academic bullying, who suffer similar repercussions, have no legal or institutional remedies. Because academic bullying is not a crime, targets often suffer in silence because there is no recourse. Read More

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http://dx.doi.org/10.34172/bi.2020.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186547PMC
November 2019

Role of the Kölliker-Fuse nucleus in cardiovascular responses to hypoxia and baroreceptor activation in anesthetized rats.

Bioimpacts 2020 2;10(1):55-61. Epub 2019 Nov 2.

Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Parabrachial Kölliker-Fuse (KF) complex, located in dorsolateral part of the pons, is involved in the respiratory control, however, its role in the baroreflex and chemoreflex responses has not been established yet. This study was performed to test the contribution of the KF to chemoreflex and baroreflex and the effect of microinjection of a reversible synaptic blocker (Cocl) into the KF in urethane anesthetized rats. Activation of chemoreflex was induced by systemic hypoxia caused by N2 breathing for 30 seconds "hypoxic- hypoxia methods" and baroreflex was evoked by intravenous injection (i. Read More

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http://dx.doi.org/10.15171/bi.2020.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977589PMC
November 2019

Propagation of limbal stem cells on polycaprolactone and polycaprolactone/gelatin fibrous scaffolds and transplantation in animal model.

Bioimpacts 2020 12;10(1):45-54. Epub 2019 Sep 12.

National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.

This study was conducted to compare the effect of nanofibrous polycaprolactone (PCL) and PCL/gelatin (PCL/Gel) on limbal epithelial stem cell (LESC) and its efficiency for transplantation in animal model. PCL and PCL/Gel with a mass ratio of 70:30 and 50:50 was fabricated by electrospinning method. Human LESCs were cultured on PCL and PCL/Gel scaffolds and the effect of each scaffold on LESC proliferation, attachment and corneal epithelial regeneration in an animal model was evaluated, considering ease of use of scaffold and final transparency of the cornea. Read More

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http://dx.doi.org/10.15171/bi.2020.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977591PMC
September 2019

Comparative impact of platelet rich plasma and transforming growth factor-β on chondrogenic differentiation of human adipose derived stem cells.

Bioimpacts 2020 2;10(1):37-43. Epub 2019 Nov 2.

Stem Cell Technology Research Center, Tehran, Iran.

Transforming growth factor-beta (TGF-β) is known as standard chondrogenic differentiation agent, even though it comes with undesirable side effects such as early hypertrophic maturation, mineralization, and secretion of inflammatory/angiogenic factors. On the other hand, platelet-rich plasma (PRP) is found to have a chondrogenic impact on mesenchymal stem cell proliferation and differentiation, with no considerable side effects. Therefore, we compared chondrogenic impact of TGF-β and PRP on adipose-derived stem cells (ADSCs), to see if PRP could be introduced as an alternative to TGF-β. Read More

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http://dx.doi.org/10.15171/bi.2020.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977594PMC
November 2019

PEGylated gold nanoparticles-ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells.

Bioimpacts 2020 25;10(1):27-36. Epub 2019 Jul 25.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, 51656-65811, Iran.

Currently, drug-induced reactive oxygen species (ROS) mediating apoptosis pathway have extensively been investigated in designing effective strategies for colorectal cancer (CRC) chemotherapy. Bovine pancreatic ribonuclease A (RNase A) represents a new class of cytotoxic and non-mutagenic enzymes, and has gained more attention as a potential anticancer modality; however, the cytosolic ribonuclease inhibitors (RIs) restrict the clinical application of this enzyme. Nowadays, nanotechnology-based diagnostic and therapeutic systems have provided potential solutions for cancer treatments. Read More

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http://dx.doi.org/10.15171/bi.2020.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977588PMC

Kinetic and thermodynamic study of beta-Boswellic acid interaction with Tau protein investigated by surface plasmon resonance and molecular modeling methods.

Bioimpacts 2020 22;10(1):17-25. Epub 2019 May 22.

Pharmacy Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.

Beta-Boswellic acid (BBA) is a pentacyclic terpene which has been obtained from frankincense and its beneficial effects on neurodegenerative disorders such as Alzheimer's disease (AD) have been addressed. In the present study, thermodynamic and kinetic aspects of BBA interaction with Tau protein as one of the important proteins involved in AD in the absence and presence of glucose has been investigated using surface plasmon resonance (SPR) method. Tau protein was immobilized onto the carboxy methyl dextran chip and its binding interactions with BBA were studied at physiological pH at various temperatures. Read More

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http://dx.doi.org/10.15171/bi.2020.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977593PMC

Incorporating ifosfamide into salvia oil-based nanoemulsion diminishes its nephrotoxicity in mice inoculated with tumor.

Bioimpacts 2020 22;10(1):9-16. Epub 2019 May 22.

Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Nephrotoxicity is one of the major side effects of the chemotherapeutic drug, ifosfamide (IFO). In this study, IFO was solubilized in nanoemulsion (NE) containing salvia (SAL) essential oil to investigate its adverse side effects in mice. One hundred female Swiss albino mice (n = 20/group) were split into five groups. Read More

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http://dx.doi.org/10.15171/bi.2020.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977592PMC

The urgent need for modification of scientific ranking indexes to facilitate scientific progress and diminish academic bullying.

Bioimpacts 2020 25;10(1):5-7. Epub 2019 Sep 25.

School of Business, Wake Forest University, NC, USA.

Academic bullying occurs when senior scientists direct abusive behavior such as verbal insults, public shaming, isolation, and threatening toward vulnerable junior colleagues such as postdocs, graduate students and lab members. We believe that one root cause of bullying behavior is the pressure felt by scientists to compete for rankings designed to measure their scientific worth. These ratings, such as the h-index, have several unintended consequences, one of which we believe is academic bullying. Read More

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http://dx.doi.org/10.15171/bi.2019.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977587PMC
September 2019

Therapeutic impacts of enzyme-responsive smart nanobiosystems.

Bioimpacts 2020 25;10(1):1-4. Epub 2019 Nov 25.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

An important arena of the sophisticated nanosystems (NSs) is the combination of the responsive features of NSs with the biocatalytic properties of enzymes. The development of such smart drug delivery systems (DDSs) has seminal effectiveness in targeting, imaging, and monitoring of cancer. These NSs can exhibit site-specific delivery of the toxic cargo in response to the endogenous/exogenous stimuli. Read More

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http://dx.doi.org/10.15171/bi.2020.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977590PMC
November 2019

Scarcity of lab positions in high-ranked institutions creates a breeding ground for bullies.

Bioimpacts 2019 23;9(4):251. Epub 2019 Oct 23.

School of Business, Wake Forest University, NC, USA.

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http://dx.doi.org/10.15171/bi.2019.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879711PMC
October 2019

In silico, in vitro: antioxidant and antihepatotoxic activity of gnetol from Brongn.

Bioimpacts 2019 22;9(4):239-249. Epub 2019 May 22.

Department of Biotechnology, Kuvempu University, Jnanasahyadri, Shankaraghatta, Shimoga, Karnataka -57745, India.

is a notable medicinal plant used to cure various ailments. The stem part of the plant is used traditionally to treat jaundice and other disorders. The present work is to investigate the hepatoprotective and antioxidant activity of ethanol extract of stem of (GUE) and its isolated compound gnetol. Read More

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http://dx.doi.org/10.15171/bi.2019.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879709PMC

Water-soluble pristine C fullerene attenuates acetaminophen-induced liver injury.

Bioimpacts 2019 22;9(4):227-237. Epub 2019 May 22.

Technical University of Ilmenau, Institute of Chemistry and Biotechnology, 25 Weimarer Str., 98693 Ilmenau, Germany.

Oxidative stress has been suggested as the main trigger and pathological mechanism of toxic liver injury. Effects of powerful free radical scavenger С fullerene on rat liver injury and liver cells (HepG2 line) were aimed to be discovered. Acute liver injury (ALI) was simulated by single acetaminophen (APAP, 1000 mg/kg) administration, on a chronic CLI, by 4 weekly APAP administrations. Read More

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http://dx.doi.org/10.15171/bi.2019.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879707PMC

Association of MS4A6A, CD33, and TREM2 gene polymorphisms with the late-onset Alzheimer's disease.

Bioimpacts 2019 22;9(4):219-225. Epub 2019 May 22.

Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.

Alzheimer's disease (AD), which is a progressive neurodegenerative disorder, causes structural and functional brain disruption. MS4A6A, TREM2, and CD33 gene polymorphisms loci have been found to be associated with the pathobiology of late-onset AD (LOAD). In the present study, we tested the hypothesis of association of LOAD with rs983392, rs75932628, and rs3865444 polymorphisms in MS4A6A, TREM2, CD33 genes, respectively. Read More

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http://dx.doi.org/10.15171/bi.2019.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879710PMC

Mode of photoexcited C fullerene involvement in potentiating cisplatin toxicity against drug-resistant L1210 cells.

Bioimpacts 2019 22;9(4):211-217. Epub 2019 May 22.

Technical University Ilmenau, Institute of Chemistry and Biotechnology, Weimarer Str., 25, 98693 Ilmenau, Germany.

C fullerene has received great attention as a candidate for biomedical applications. Due to unique structure and properties, C fullerene nanoparticles are supposed to be useful in drug delivery, photodynamic therapy (PDT) of cancer, and reversion of tumor cells' multidrug resistance. The aim of this study was to elucidate the possible molecular mechanisms involved in photoexcited C fullerene-dependent enhancement of cisplatin toxicity against leukemic cells resistant to cisplatin. Read More

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http://dx.doi.org/10.15171/bi.2019.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879712PMC

Design, synthesis and evaluation of biological activities of some novel anti-TB agents with bio-reducible functional group.

Bioimpacts 2019 22;9(4):199-209. Epub 2019 May 22.

Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.

With regard to the anti-mycobacterial activity of 2-pyrazinoic acid esters (POEs), recent studies have shown that both pyrazine core and alkyl part of POE interact with the fatty acid synthase type (I) (FAS (I)) precluding a complex formation between NADPH and FAS (I). Considering this interaction at the reductase site of FAS (I) responsible for reduction of β-ketoacyl-CoA to β-hydroxyacyl-CoA, we hypothesized that POE containing a bioreducible center in its alkyl part might show an increased anti-tubercular activity due to the involvement of FAS (I) in extra bio-reduction reaction. Thus, we synthesized novel POEs, confirmed their structures by spectral data, and subsequently evaluated their anti-mycobacterial activity against (Mtb) (H37Rv) strain at 10 μg/mL concentration. Read More

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http://dx.doi.org/10.15171/bi.2019.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879708PMC

Renewed interests in carbonic anhydrase IX in relevance to breast cancer treatment.

Bioimpacts 2019 27;9(4):195-197. Epub 2019 Aug 27.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

The highly proliferating cancerous cells can form permissive accommodating milieu - the so-called tumor microenvironment (TME). During the initiation of solid tumors, hypoxia plays a key role in glycolysis, which can trigger the anomalous overexpression of several enzymes and transporters involved in the metabolism of glucose. Of these, carbonic anhydrases (CAs), especially CAIX, together with other molecular machinery involved in the production/trafficking of acidic byproducts, play key roles in the regulation of intracellular and extracellular pH. Read More

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http://dx.doi.org/10.15171/bi.2019.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879713PMC

Manifestation of hemispheric laterality in chewing side preference and handedness.

Bioimpacts 2019 15;9(3):189-193. Epub 2019 Apr 15.

Self-awareness Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Humans manifest a behavioral inclination towards more utility of one side of the body, in relation with the dominant hemisphere of the brain. The current investigation assessed handedness together with chewing preference which have not been evaluated in various food textures before. Nineteen young and healthy volunteers chewed hard (walnut) and soft (cake) foods, during surface electromyography recording from masseter muscles. Read More

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http://dx.doi.org/10.15171/bi.2019.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726748PMC

Electrosprayed polymeric nanobeads and nanofibers of modafinil: preparation, characterization, and drug release studies.

Bioimpacts 2019 15;9(3):179-188. Epub 2019 Apr 15.

Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Modafinil (MDF) is used orally for the treatment of attention-deficit/hyperactivity disorder and narcolepsy. It holds low solubility and high permeability; therefore, improving its dissolution properties by preparing nanoformulations can be a promising approach to enhance its oral absorption. Our aims were to prepare and characterize MDF-Eudragit® RS100 (MDF-ERS) nanoparticles by electrospray technique. Read More

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http://dx.doi.org/10.15171/bi.2019.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726752PMC
April 2019
3 Reads

The effects of natural nano-sized clinoptilolite and supplementation on serum bone markers in diabetic rats.

Bioimpacts 2019 15;9(3):173-178. Epub 2019 Apr 15.

Student Research Committee, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Many studies confirm that diabetes mellitus is associated with higher risks of bone fracture. The beneficial effects of (NS) and clinoptilolite in preventing/reducing some diabetes-related disorders have been shown. This study was conducted to examine the effects of separate and concurrent supplementation of natural nano-sized clinoptilolite (NCLN) and NS on serum bone markers in rats with type 2 diabetes. Read More

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http://dx.doi.org/10.15171/bi.2019.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726750PMC
April 2019
2 Reads

A short-term plastic adherence incubation of the stromal vascular fraction leads to a predictable GMP-compliant cell-product.

Bioimpacts 2019 25;9(3):161-172. Epub 2019 Mar 25.

OXACELL® AG, Potsdam, Germany.

Mesenchymal stromal/stem cells (MSCs) derived from fat tissue are an encouraging tool for regenerative medicine. They share properties similar to the bone marrow-derived MSCs, but the amount of MSCs per gram of fat tissue is 500x higher. The fat tissue can easily be digested by collagenase, releasing a heterogeneous cell fraction called stromal vascular fraction (SVF) which contains a variable amount of stromal/stem cells. Read More

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http://dx.doi.org/10.15171/bi.2019.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726751PMC

Functional expression and impact of testis-specific gene antigen 10 in breast cancer: a combined in vitro and in silico analysis.

Bioimpacts 2019 8;9(3):145-159. Epub 2019 Mar 8.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Testis-specific gene antigen 10 () is a less-known gene, which is involved in the vague biological paths of different cancers. Here, we investigated the expression using different concentrations of glucose under hypoxia and also its interaction with the hypoxia-inducible factor 1 (HIF-1). The breast cancer MDA-MB-231 and MCF-7 cells were cultured with different concentrations of glucose (5. Read More

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http://dx.doi.org/10.15171/bi.2019.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726749PMC
March 2019
1 Read

A multi-method and structure-based in silico vaccine designing against through investigating enolase protein.

Bioimpacts 2019 8;9(3):131-144. Epub 2019 Mar 8.

Department of Pathobiology, Veterinary College, University of Tabriz, Tabriz, Iran.

Hydatid disease is a ubiquitous parasitic zoonotic disease, which causes different medical, economic and serious public health problems in some parts of the world. The causal organism is a multi-stage parasite named whose life cycle is dependent on two types of mammalian hosts viz definitive and intermediate hosts. In this study, enolase, as a key functional enzyme in the metabolism of (EgEnolase), was targeted through a comprehensive modeling analysis and designing a host-specific multi-epitope vaccine. Read More

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http://dx.doi.org/10.15171/bi.2019.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726745PMC
March 2019
2 Reads

Academic bullies leave no trace.

Authors:
Morteza Mahmoudi

Bioimpacts 2019 26;9(3):129-130. Epub 2019 May 26.

Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Bullying in academic science is a growing concern. It may vary in severity from insults, snubs, or invasions of privacy to violations of intellectual property and unfair crediting of authors. In extreme cases it may even include coercing lab workers to sign away rights to authorship or even intellectual property. Read More

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http://dx.doi.org/10.15171/bi.2019.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726746PMC
May 2019
1 Read

Recent advances in targeted therapy of colorectal cancer: impacts of monoclonal antibodies nanoconjugates.

Bioimpacts 2019 8;9(3):123-127. Epub 2019 Mar 8.

Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Despite rapid advances in diagnostic and treatment approaches, the overall survival rate of cancer has not been improved. Colorectal cancer (CRC) is recognized as the third leading cause of neoplasm-related deaths worldwide, in large part due to its considerable metastasis and drug resistance. For developing new anticancer strategies, rapid progression of multimodal nanomedicines and nanoconjugates has provided promising treatment modalities for effective therapy of cancer. Read More

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http://dx.doi.org/10.15171/bi.2019.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726747PMC

Spectroscopic overview of quercetin and its Cu(II) complex interaction with serum albumins.

Bioimpacts 2019 25;9(2):115-121. Epub 2019 Mar 25.

Department of Chemistry, Presidency University, 86/1 College Street, Kolkata 700073, India.

Flavonoids are widely used as dietary supplements, and thus, play a significant role in the research field. In recent time, the interaction of flavonoid-metal complexes with serum albumin (SA) has widely been studied since the complexation poses a significant impact on biological activities. Additionally, the binding nature of flavonoids with SA gets modified in the presence of metal ions. Read More

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http://dx.doi.org/10.15171/bi.2019.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637219PMC

Determination of valproic acid and 3-heptanone in plasma using air-assisted liquid-liquid microextraction with the assistance of vortex: Application in the real samples.

Bioimpacts 2019 8;9(2):105-113. Epub 2019 Mar 8.

Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Valproic acid (VPA) is an antiepileptic drug used to treat epilepsy and bipolar disorder. Adverse effects of VPA were studied in many reports, however, a dose-response relationship between VPA and its metabolites in epilepsy patients are extremely limited. In this paper, a high efficient method was developed for the preconcentration and determination of VPA and its main metabolite in plasma. Read More

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http://dx.doi.org/10.15171/bi.2019.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637214PMC
March 2019
2 Reads

Numerical investigation of hemodynamic performance of a stent in the main branch of a coronary artery bifurcation.

Bioimpacts 2019 8;9(2):97-103. Epub 2019 Mar 8.

Department of Mechanical Engineering, University of Tabriz, Tabriz, Iran.

The effect of a bare-metal stent on the hemodynamics in the main branch of a coronary artery bifurcation with a particular type of stenosis was numerically investigated by the computational fluid dynamics (CFD). Three-dimensional idealized geometry of bifurcation was constructed in Catia modelling commercial software package. The Newtonian blood flow was assumed to be incompressible and laminar. Read More

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http://dx.doi.org/10.15171/bi.2019.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637217PMC

Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an prediction.

Bioimpacts 2019 8;9(2):89-95. Epub 2019 Mar 8.

Department of Pathology, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Focal segmental glomerulosclerosis (FSGS), the most common primary glomerular disease, is a diverse clinical entity that occurs after podocyte injury. Although numerous studies have suggested molecular pathways responsible for the development of FSGS, many still remain unknown about its pathogenic mechanisms. Two important pathways were predicted as candidates for the pathogenesis of FSGS in our previous analysis, whom we aim to confirm experimentally in the present study. Read More

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http://dx.doi.org/10.15171/bi.2019.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637215PMC

Therapeutic potency of substituted chromones as Alzheimer's drug: Elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation.

Bioimpacts 2019 8;9(2):79-88. Epub 2019 Mar 8.

Centre for Advanced Studies in Chemistry, North-Eastern Hill University, Shillong - 793 022, India.

Documentation on the potency of chromones as acetylcholinesterase (AChE) antagonists has paved the way for the design and usage of new chromone analogues as inhibitors of AChE modelled on the hypothesis based on cholinergic pathway of Alzheimer's disease (AD). Here, 2 minimally substituted chromones, namely 3-cyanochromone (CyC) and 7-amino-3- methylchromone (AMC), were checked for their AChE inhibition efficacies and plasma protein modulation. Colorimetric enzymatic assay as well as fluorescence measurements were performed for obtaining the experimental results, which were further corroborated by molecular docking and simulation studies. Read More

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http://dx.doi.org/10.15171/bi.2019.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637216PMC

SPR signals enhancement by gold nanorods for cell surface marker detection.

Bioimpacts 2019 20;9(2):71-78. Epub 2018 Oct 20.

Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.

The detection of micrometer-sized particles like cells is limited by surface plasmon resonance (SPR) biosensors because of having a depth of evanescent wave <500 nm. In this study, for the first time, we exhibited the use of streptavidin-functionalized gold nanorods (GNRs) as intensification labels for detection of cell surface markers in SPR-based biosensors. The GNRs (ʎ max: 735 nm) were modified with streptavidin using EDC/NHS coupling method and human umbilical vein endothelial cells (HUVECs) were selected as the cell model for detecting VE-cadherin on cell surface using real-time SPR device in the 785 nm wavelength of the laser source. Read More

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http://dx.doi.org/10.15171/bi.2019.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637213PMC
October 2018

Aptamedicine: a new treatment modality in personalized cancer therapy.

Bioimpacts 2019 30;9(2):67-70. Epub 2018 Nov 30.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Aptamers ( Aps ) are short single-strand nucleic acids exhibiting unique 3D structure which facilitate their targeting potential against various cancer molecular markers ( CMMs ). Such features of Aps not only make them as suitable homing agents in targeted drug delivery systems (DDSs) but also candidate them as macromolecules that inhibit the interaction of the target ligand with other proteins. On the other hand, the conjugation of Aps with another therapeutic molecule such as antisense oligonucleotides (ASOs), siRNAs/miRNAs, Aps , toxins, chemotherapeutic agents, DNAzymes/Ribozymes provides hopeful strategy to eradicate the malignancies and overcome the off-target unwanted side effects. Read More

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http://dx.doi.org/10.15171/bi.2019.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637218PMC
November 2018
1 Read

In vitro study of the anticancer activity of various doxorubicin-containing dispersions.

Bioimpacts 2019 14;9(1):57-63. Epub 2018 Oct 14.

Technical University Ilmenau, Institute of Chemistry and Biotechnology, Weimarer Str., 25, 98693 Ilmenau, Germany.

The aim of this research was to study the impact of various doxorubicin (Dox)-containing nanofluids, e.g. singlewalled carbon nanotube (SWCNT)+Dox, graphene oxide (GO)+Dox and DextranPNIPAM (copolymer)+Dox mixtures on HeLa cells (human transformed cervix epithelial cells, as a model for cancer cells) depending on their concentration. Read More

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http://dx.doi.org/10.15171/bi.2019.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378100PMC
October 2018
3 Reads

design of a triple-negative breast cancer vaccine by targeting cancer testis antigens.

Bioimpacts 2019 2;9(1):45-56. Epub 2018 Jul 2.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Triple-negative breast cancer (TNBC) is an important subtype of breast cancer, which occurs in the absence of estrogen, progesterone and HER-2 receptors. According to the recent studies, TNBC may be a cancer testis antigen (CTA)-positive tumor, indicating that the CTA-based cancer vaccine can be a treatment option for the patients bearing such tumors. Of these antigens (Ags), the MAGE-A family and NY-ESO-1 as the most immunogenic CTAs are the potentially relevant targets for the development of an immunotherapeutic way of the breast cancer treatment. Read More

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http://dx.doi.org/10.15171/bi.2019.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378095PMC
July 2018
1 Read

Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin.

Bioimpacts 2019 7;9(1):37-43. Epub 2018 Oct 7.

Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Rajpura-140401, Patiala, Punjab, India.

Skin can be used as a site for local and systemic drug administration. Diffusion of drugs through the skin has led to the development of different transdermal drug delivery systems. Curcumin is a wound healing and anti-inflammatory agent. Read More

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http://dx.doi.org/10.15171/bi.2019.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378101PMC
October 2018
1 Read

and evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent.

Bioimpacts 2019 2;9(1):25-36. Epub 2018 Oct 2.

INSERM, UMR_S1148, Laboratory for Vascular Translational Sciences, Hôpital Bichat.

The major complications of stent implantation are restenosis and late stent thrombosis. PBMA polymers are used for stent coating because of their mechanical properties. We previously synthesized and characterized Dextrangraft-polybutylmethacrylate copolymer (Dex-PBMA) as a potential stent coating. Read More

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http://dx.doi.org/10.15171/bi.2019.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378099PMC
October 2018
4 Reads

Highly efficient novel recombinant L-asparaginase with no glutaminase activity from a new halo-thermotolerant strain.

Bioimpacts 2019 13;9(1):15-23. Epub 2018 Sep 13.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The bacterial enzyme has gained more attention in therapeutic application because of the higher substrate specificity and longer half-life. L-asparaginase is an important enzyme with known antineoplastic effect against acute lymphoblastic leukemia (ALL). Novel L-asparaginase genes were identified from a locally isolated halo-thermotolerant strain and the recombinant enzymes were overexpressed in modified strains, Origami B and BL21. Read More

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http://dx.doi.org/10.15171/bi.2019.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378094PMC
September 2018
2 Reads

Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent.

Bioimpacts 2019 18;9(1):5-13. Epub 2018 Jul 18.

Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.

In recent years, more attention was dedicated to developing new methods for designing of drug delivery systems. The aim of present work is to improve the efficiency of the antibacterial drug delivery process, and to realize and to control accurately the release. First, graphene oxide (GO) was prepared according to the modified Hummers method then the GO was modified with carboxymethylcellulose (CMC) and Zn-based metal-organic framework (MOF-5) through the solvothermal technique. Read More

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https://bi.tbzmed.ac.ir/Abstract/bi-17635
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http://dx.doi.org/10.15171/bi.2019.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378098PMC
July 2018
6 Reads

Indoleamine 2, 3-dioxygenase inhibitors in immunochemotherapy of breast cancer: challenges and opportunities.

Bioimpacts 2019 21;9(1):1-3. Epub 2018 Oct 21.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Trafficking of macromolecular immunotherapy agent into the tumor microenvironment (TME) is a challenging issue. In the TME, cancer cells exploit indoleamine 2, 3-dioxygenase (IDO), as a cytosolic enzyme that catalyzes the L-tryptophan (Trp) through the kynurenine (Kyn) pathway, which could negatively regulate the activity of T cells. Thus, Trp/Kyn pathway, can be targeted with novel treatment modalities such as IDO1 inhibitor to benefit patients with aggressive solid tumors. Read More

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http://dx.doi.org/10.15171/bi.2019.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378097PMC
October 2018
1 Read

Retraction Note: Inhibition of hTERT Gene Expression by SilibininLoaded PLGA-PEG-Fe₃O₄ in T47D Breast Cancer Cell Line.

Bioimpacts 2018 16;8(4):321. Epub 2018 Sep 16.

Faculty of Advanced Medical Sciences, Department of Medical Biotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.

[This retracts the article DOI: 10.5681/bi.2013. Read More

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http://bi.tbzmed.ac.ir/Abstract/bi-19682
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http://dx.doi.org/10.15171/bi.2018.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209827PMC
September 2018
18 Reads

Recent advances in improving oral drug bioavailability by cocrystals.

Bioimpacts 2018 31;8(4):305-320. Epub 2018 May 31.

Biotechnology Research Center, and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy. Improving oral absorption of drugs with low water solubility and/or low intestinal membrane permeability is an active field of research. Read More

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http://bi.tbzmed.ac.ir/Abstract/bi-17553
Publisher Site
http://dx.doi.org/10.15171/bi.2018.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209825PMC
May 2018
28 Reads

An fMRI investigation of the neural correlates underlying the autonomous sensory meridian response (ASMR).

Bioimpacts 2018 23;8(4):295-304. Epub 2018 Sep 23.

Center for Cognitive Neuroscience, Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.

: The "autonomous sensory meridian response" (ASMR) is a neologism used to describe an internal sensation of deep relaxation and pleasant head tingling which is often stimulated by gentle sounds, light touch, and personal attention. : An fMRI-based methodology was employed to examine the brain activation of subjects prescreened for ASMR-receptivity (n=10) as they watched ASMR videos and identified specific moments of relaxation and tingling. : Subjects who experienced ASMR showed significant activation in regions associated with both reward (NAcc) and emotional arousal (dACC and Insula/IFG). Read More

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http://bi.tbzmed.ac.ir/Abstract/bi-17613
Publisher Site
http://dx.doi.org/10.15171/bi.2018.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209833PMC
September 2018
10 Reads

Comparative in vitro/theoretical studies on the anti-angiogenic activity of date pollen hydro-alcoholic extract: Highlighting the important roles of its hot polyphenols.

Bioimpacts 2018 14;8(4):281-294. Epub 2018 Jun 14.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Date palm pollen (DPP) is the male reproductive soft powder from date flowers widely used as the valuable dietary supplement to fortify the size of testis and ovarian to increase the power of sex. This part of date palm significantly exhibited anti-diabetic, anti-inflammation and protective effects against male and female infertility. Though the anticancer activity of date fruits was previously reported, the DPP anti-angiogenic effects were not reported, and as the first study, its inhibitory effects were examined in the current study. Read More

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http://bi.tbzmed.ac.ir/Abstract/bi-17576
Publisher Site
http://dx.doi.org/10.15171/bi.2018.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209826PMC
June 2018
43 Reads