1,900 results match your criteria Bio-medical materials and engineering[Journal]


The role of osteoclasts in osteoinduction triggered by calcium phosphate biomaterials in mice.

Biomed Mater Eng 2019 Apr 11. Epub 2019 Apr 11.

Medical School, Chengdu University, Chengdu, China.

Objective: Bone remodeling is mediated by the interaction between osteoblasts and osteoclasts, so does osteoinduction triggered by calcium phosphate (CaP) biomaterials. This study aims to investigate the role and function of osteoclasts in ectopic bone formation induced by CaP biomaterials.

Methods: Four kinds of mice, two outbred mouse strains (KM and ICR) and two inbred mouse strains (C57BL/6 and BALB/c), were chosen for the experiments. Read More

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http://dx.doi.org/10.3233/BME-191052DOI Listing
April 2019
2 Reads

Effect of sodium hypochlorite and chlorhexidine irrigating solutions and their inactivating agents on the push-out bond strength of mineral trioxide aggregate.

Biomed Mater Eng 2019 Apr 11. Epub 2019 Apr 11.

Department of Endodontics, Faculty of Dentistry, Ondokuz Mayıs University, Samsun, Turkey.

The objective of this study was to evaluate the effect of sodium hypochlorite and chlorhexidine solutions and their inactivating agents on the push-out bond strength of mineral trioxide aggregate (MTA). One hundred fifty root slices were prepared and their root canal spaces were enlarged using diamond burs. MTA was prepared and compacted to root canal spaces. Read More

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http://dx.doi.org/10.3233/BME-191051DOI Listing

Three-dimensional modeling of a Marfan syndrome with elastic and hyperelastic materials assumptions using fluid-structure interaction.

Biomed Mater Eng 2019 Apr 10. Epub 2019 Apr 10.

School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran.

Background: Marfan Syndrome (MFS) is a genetic disorder of the connective tissue. It most prominently influences the skeletal, cardiovascular, and ocular systems, but all fibrous connective tissue throughout the body can be affected as well.

Objective: This study aims to investigate a realistic three-dimensional model of an aorta of a specific patient suffering from MFS by considering elastic and hyperelastic materials for the tissue using fluid-structure interaction (FSI). Read More

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http://dx.doi.org/10.3233/BME-191049DOI Listing

Frequency and chaotic analysis of pulsatile motion of blood vessel wall related to aneurysm.

Biomed Mater Eng 2019 ;30(2):243-253

Division of Cardiovascular Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.

Background/objective: In this research, using our proposed method, clinical measurements on the pulsatile velocity of blood vessel wall were conducted for cases with aneurysm. Furthermore, detailed analyses of frequency and attracter of trajectories of velocity of blood vessel wall were conducted. On the basis of these analyses, we tried to conduct unified clarification of the change and disturbance of frequency and wave form of pulsatile velocity of blood vessel wall caused by blood vessel diseases such as aneurysm. Read More

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http://dx.doi.org/10.3233/BME-191048DOI Listing
January 2019
1 Read

A novel diagnostic system for Doppler ultrasound of the peripheral arteries to detect the presence of thoracic aortic aneurysm.

Biomed Mater Eng 2019 ;30(2):231-241

Division of Cardiovascular Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.

Objective: We aimed to develop a novel ultrasound system and examine its feasibility for noninvasively detecting thoracic aortic aneurysm (TAA) in clinical settings.

Methods: We developed a novel ultrasound system consisting of a modified console and data analysis algorithm. The exploratory study included 100 patients hospitalized for elective cardiovascular surgery. Read More

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http://dx.doi.org/10.3233/BME-191047DOI Listing
January 2019
8 Reads

Ultrasound elastographic assessment of the stiffness of the anteromedial knee joint capsule at varying knee angles.

Biomed Mater Eng 2019 ;30(2):219-230

Graduate School of Health Sciences, Niigata University, Niigata, Japan.

Background: In vivo evaluation of the elastic properties of the knee joint capsule has not been adequately performed.

Objectives: To establish a methodology to assess the stiffness of the normal knee joint capsule over a range of knee flexion angles using ultrasound elastography.

Methods: Ultrasound elastography with an acoustic coupler was used to assess the stiffness of the anteromedial capsule of the knee joints of 10 male (mean age 22. Read More

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http://dx.doi.org/10.3233/BME-191046DOI Listing
January 2019
13 Reads

Component effects of bioactive glass on corrosion resistance and in vitro biological properties of apatite-matrix coatings.

Biomed Mater Eng 2019 ;30(2):207-218

Institute of Oral Science, Chung Shan Medical University, Taichung City 402, Taiwan.

Background: Surface modification of metallic implants is critical for improving the clinical performance of the dental and orthopedic devices. Bioactive glasses exhibit different levels of cellular function and physicochemical behavior; however, there have been few previous studies on the effect of constituents of the bioactive glasses on the in vitro osteogenic activity and corrosion resistance of apatite-based coatings.

Objective: The objective of this work was to investigate the effect of SiO2, CaO, Na2O, and P2O5 on plasma-sprayed apatite coatings on Ti alloy substrates for tailoring the properties of implants making them suitable for clinical applications. Read More

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http://dx.doi.org/10.3233/BME-191045DOI Listing
January 2019

Combination of freeze-thaw with detergents: A promising approach to the decellularization of porcine carotid arteries.

Biomed Mater Eng 2019 ;30(2):191-205

Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China.

Background: A tissue engineering technique based on use of the extracellular matrix (ECM) as a scaffold shows great potential for preparing small-caliber vascular grafts. Decellularization protocols are still not standardized for bioengineering. The effects of freeze-thaw cycles used for decellularization are unknown. Read More

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http://dx.doi.org/10.3233/BME-191044DOI Listing
January 2019
6 Reads
0.847 Impact Factor

Experimental analysis of the quality of an implant embedded in the bone based on its mechanical parameters.

Authors:
Marcin Zaczyk

Biomed Mater Eng 2019 ;30(2):183-190

Division of Design of Precision Devices, Institute of Micromechanics and Photonics, Faculty of Mechatronics, Warsaw University of Technology, Warsaw, Poland.

Background/objective: We present a description of an experiment in which the parameters describing the quality of the mandrel embedding an implant into a bone were determined. A method was developed that allows, from outside a living organism, the strength of the mandrel of the implant in the bone tissue to be determined. Using the proposed technique, we investigated how the mechanical properties of the bone affect the quality of the implant mandrel embedding in the bone tissue. Read More

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http://dx.doi.org/10.3233/BME-191043DOI Listing
January 2019
5 Reads

Biomechanical effect with respect to the sagittal positioning of the femoral component in unicompartmental knee arthroplasty.

Biomed Mater Eng 2019 ;30(2):171-182

Department of Mechanical Engineering, Yonsei University, Seoul, Republic of Korea.

Background: Component malalignment in unicompartmental knee arthroplasty (UKA) has been related to the concentration in tibiofemoral joint of contact stress and to poor post-operative outcomes. Few studies investigated a biomechanical effect of femur component position in sagittal plane. The purpose of this study was to evaluate the biomechanical effect of the femoral components on the sagittal alignment under flexion and extension conditions using computational simulations. Read More

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http://dx.doi.org/10.3233/BME-191042DOI Listing
January 2019
2 Reads

Biomechanical analysis of a changed posterior condylar offset under deep knee bend loading in cruciate-retaining total knee arthroplasty.

Biomed Mater Eng 2019 ;30(2):157-169

Department of Orthopaedic Surgery, Joint Reconstruction Center, Yonsei Sarang Hospital, Seoul, Republic of Korea.

Background: The conservation of the joint anatomy is an important factor in total knee arthroplasty (TKA). The restoration of the femoral posterior condylar offset (PCO) has been well known to influence the clinical outcome after TKA.

Objective: The purpose of this study was to determine the mechanism of PCO in finite element models with conservation of subject anatomy and different PCO of ±1, ±2, ±3 mm in posterior direction using posterior cruciate ligament-retaining TKA. Read More

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http://dx.doi.org/10.3233/BME-191041DOI Listing
January 2019
1 Read

Effect of ageing and endodontic treatment on the thermal stability of human dentin.

Biomed Mater Eng 2019 ;30(2):145-156

Department of Operative Dentistry and Endodontics, Medical University - Plovdiv, Plovdiv, Bulgaria.

Background: Human dentin is a highly calcified tissue of mesenchymal origin with a heterogeneous structure. Its morphology is constantly remodelled throughout the life span of the tooth, as well as under the influence of external stimuli.

Objective: The aim of the present study was to obtain information about the thermal changes in the crown and root dentin specimens of vital and devitalized teeth. Read More

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http://dx.doi.org/10.3233/BME-191040DOI Listing
January 2019

Biomechanical effects of posterior tibial slope on unicompartmental knee arthroplasty using finite element analysis.

Biomed Mater Eng 2019 ;30(2):133-144

Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: The effects of the posterior slope of the tibial prosthesis on unicompartmental knee arthroplasty have not been fully evaluated and controversies still exist.

Objective: This study evaluates the effects of the posterior slope of the tibia on contact stresses in polyethylene inserts and articular cartilage using finite element analysis.

Methods: We generated a computational model followed by the development of a posterior tibial slope (PTS) from -1° to 15° cases with increments of 2° PTS models. Read More

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http://dx.doi.org/10.3233/BME-191039DOI Listing
January 2019
4 Reads

Development of decellularized meniscus extracellular matrix and gelatin/chitosan scaffolds for meniscus tissue engineering.

Biomed Mater Eng 2019 ;30(2):125-132

State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China.

Background: Meniscus tissue engineering has provided a great potential treatment for meniscal injuries. However, few scaffolds in meniscus tissue engineering have matched the mechanical properties of native meniscus.

Objective: In this study, we developed a composite scaffold using decellularized meniscus extracellular matrix (DMECM) and gelatin/chitosan (G/C) to explore a preferable ratio to enhance the elastic modulus and cytotoxicity properties of scaffolds. Read More

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http://dx.doi.org/10.3233/BME-191038DOI Listing
January 2019
4 Reads

Polyamidoamine dendrimer-PEG hydrogel and its mechanical property on differentiation of mesenchymal stem cells.

Biomed Mater Eng 2019 ;30(1):111-123

Department of Physical Sciences, Charleston Southern University, Charleston, South Carolina, USA.

Background: Biocompatible hydrogel systems with tunable mechanical properties have been reported to influence the behavior and differentiation of mesenchymal stem cells (MSCs).

Objective: To develop a functionalized hydrogel system with well-defined chemical structures and tunable mechanical property for regulation of stem cell differentiation.

Methods: An in situ-forming hydrogel system is developed by crosslinking vinyl sulfone functionalized polyamidoamine (PAMAM) dendrimer and multi-armed thiolated polyethylene glycol (PEG) through a thiol-ene Michael addition in aqueous conditions. Read More

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http://dx.doi.org/10.3233/BME-181037DOI Listing
January 2019
3 Reads
0.847 Impact Factor

Evaluation of in vitro bioactivity and in vitro biocompatibility of Polycaprolactone/Hyaluronic acid/Multiwalled Carbon Nanotubes/Extract from Mimosa tenuiflora composites.

Biomed Mater Eng 2019 ;30(1):97-109

Instituto de Arquitectura, Diseño y Arte, Universidad Autónoma de Cd. Juárez, Av. Del Charro 450 Norte. Col. Universidad, Cd. Juárez, Chihuahua, México.

Background: The development of biomaterial scaffolds and implementation of tissue engineering techniques are necessary. Therefore, Polycaprolactone/Sodium Hyaluronate/Multiwalled Carbon Nanotubes/Extract of Mimosa tenuiflora composites have been produced by a thermally-induced phase separation method.

Objective: The objective of this research was to evaluate the in vitro bioactivity and in vitro biocompatibility of the composites. Read More

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http://dx.doi.org/10.3233/BME-181036DOI Listing
January 2019
9 Reads

The topography and proliferative activity of cells immunoreactive to various growth factors in rat femoral bone tissues after experimental fracture and implantation of titanium implants with bioactive biodegradable coatings.

Biomed Mater Eng 2019 ;30(1):85-95

Department of Histology, Cytology and Embryology, Pacific State Medical University, Vladivostok, Russia.

Background: Biodegradable implant coatings promote proliferation and expression of BMP-2, VEGF, and TGF-β2 genes and enhance BMP-2, VEGF, and TGF-β2 regulatory effects at different stages of reparative osteogenesis.

Objective: To study the topography and ratio of PCNA-, VEGF-, BMP-2-, and TGF-β2-immunoreactive cells in rat femoral bone after closed fracture and implantation of titanium implants with biodegradable calcium phosphate and hydroxyapatite coatings.

Methods: Standard titanium implant screws and similar implants with bioactive coatings were used. Read More

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http://dx.doi.org/10.3233/BME-181035DOI Listing
January 2019

Simultaneous quantitative analysis of indomethacin and benzoic acid in gel using ultra-violet-visible spectrophotometry and chemometrics.

Biomed Mater Eng 2019 ;30(1):73-84

Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Shinmachi, Nishi-Tokyo, Japan.

Background: In order to manufacture pharmaceutical products, real-time monitoring in the manufacturing process is necessary, but large equipment cost is required to achieve it.

Objective: The aim of this research is to use ultra-violet-visible spectroscopy along with chemometrics procedure to simultaneously carry out quantitative analysis of indomethacin (IMC) and benzoic acid (BA) in the gel during pharmaceutical manufacturing process.

Methods: The gel preparations contained 0. Read More

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http://dx.doi.org/10.3233/BME-181034DOI Listing
January 2019

Availability of ultrasound screening for asymptomatic elbow injuries in judo athletes.

Biomed Mater Eng 2019 ;30(1):49-59

Department of Orthopedic Surgery, Kawakita General Hospital, 1-7-3 Asagaya-kita, Suginami, Tokyo, Japan.

Objective: We conducted ultrasonography (US) examination for asymptomatic elbow injuries in judo athletes to confirm availability of US screening for elbow.

Materials And Methods: One hundred and thirty-two black belts in judo (85 males and 47 females; mean age, 20.0 ± 1. Read More

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http://dx.doi.org/10.3233/BME-181032DOI Listing
January 2019
1 Read

Hemocompatibility assay of a micro-catheter using hydrophilic coating biomaterials.

Biomed Mater Eng 2019 ;30(1):1-9

Shandong Quality Inspection Center for Medical Devices, Jinan, China.

For medical devices directly or indirectly contacted with blood, hemocompatibility assay is of great importance during the biological evaluation. In ISO 10993-4:2017 - Biological evaluation of medical devices part 4, a selection of tests for interactions with blood is given with the rationale for selection of tests based on their intended use specified, however, the specific testing protocols may vary significantly when performing the hemocompatibility assays. In recent years, medical catheters have been widely used in clinical practice. Read More

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http://dx.doi.org/10.3233/BME-181028DOI Listing
January 2019

Recellularization potential of small diameter vascular grafts derived from human umbilical artery.

Biomed Mater Eng 2019 ;30(1):61-71

Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Athens, Greece.

Background: The primary therapeutic strategy in cardiovascular disease is the coronary artery bypass surgery, which in- volves the use of small diameter vascular grafts (<6 mm). Human umbilical arteries could be used as a source for the development of these grafts.

Objective: The aim of this study was the decellularization of human umbilical arteries and the evaluation of their re- cellularization potential. Read More

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http://dx.doi.org/10.3233/BME-181033DOI Listing
January 2019

A feasibility study of a multimodal stimulation bioreactor for the conditioning of stem cell seeded cardiac patches via electrical impulses and pulsatile perfusion.

Biomed Mater Eng 2019 ;30(1):37-48

Department of Cardiac Surgery, Laboratory for Tissue Engineering, Grosshadern Medical Centre, Ludwig Maximilian University, Munich, Germany.

Background/objective: Ischemic heart disease is a major cause of mortality worldwide. Myocardial tissue engineering aims to create transplantable units of myocardium for the treatment of myocardial necrosis caused by ischemic heart disease - bioreactors are used to condition these bioartificial tissues before application.

Methods: Our group developed a multimodal bioreactor consisting of a linear drive motor for pulsatile flow generation (500 ml/min) and an external pacemaker for electrical stimulation (10 mA, 3 V at 60 Hz) using LinMot-Talk Software to synchronize these modes of stimulation. Read More

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http://dx.doi.org/10.3233/BME-181031DOI Listing
January 2019
1 Read

Evaluation of the degradation, biocompatibility and osteogenesis behavior of lithium-doped calcium polyphosphate for bone tissue engineering.

Biomed Mater Eng 2019 ;30(1):23-36

Department of Orthopaedics Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu, P.R. China.

Background: Calcium polyphosphate (CPP) is a commonly used biomaterial in bone tissue engineering, but CPP is insufficient in osteoinduction. This study aimed to fabricate lithium doped CPP (LiCPP) scaffolds and assess their characterization, degradation, biocompatibility and osteogenesis behavior for bone tissue engineering.

Methods: The novel scaffold was characterized by XRD, FTIR and SEM. Read More

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http://dx.doi.org/10.3233/BME-181030DOI Listing
January 2019
1 Read

Preparation, physicochemical characterization and pharmacokinetics of paeoniflorin-phospholipid complex.

Biomed Mater Eng 2019 ;30(1):11-22

Anhui Medical College, Hefei, Anhui, China.

In order to enhance lipophilicity and oral bioavailability of paeoniflorin (PF), this study developed paeoniflorin-phospholipid complex (PF-PLC) by solvent-evaporation method. The optimum preparation technology of PF-PLC was screened by the combination of single factor and orthogonal experiment. The physicochemical properties of PF-PLC were evaluated via differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and oil-water partition coefficient study (lgP). Read More

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http://dx.doi.org/10.3233/BME-181029DOI Listing
January 2019
2 Reads

Aligned polyvinylpyrrolidone nanofibers with advanced electrospinning for biomedical applications.

Biomed Mater Eng 2018 ;29(5):685-697

Deparment of Control and Automation Engineering, Istanbul Technical University, 34467 Istanbul, Turkey.

Background: Electrospinning is a highly effective method in order to generate nano-scaled fibers. In conventional electrospinning technique, geometry of nanofibers are mostly random due to the chaotic behavior of polymer jet.

Objective: Purpose of this study is to produce aligned nanofibers from PVP polymers with advanced electrospinning technique in order to be used in a potential novel sensor applications, tissue regeneration and engineering. Read More

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http://dx.doi.org/10.3233/BME-181017DOI Listing
February 2019
1 Read

Scaffolds of bioactive glass-ceramic (Biosilicate®) and bone healing: A biological evaluation in an experimental model of tibial bone defect in rats.

Biomed Mater Eng 2018 ;29(5):665-683

Department of Bioscience, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.

This study aimed to investigate the in vivo tissue response of the Biosilicate® scaffolds in a model of tibial bone defect. Sixty male Wistar rats were distributed into bone defect control group (CG) and Biosilicate® scaffold group (BG).  Animals were euthanized 15, 30 and 45 days post-surgery. Read More

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http://dx.doi.org/10.3233/BME-181016DOI Listing
February 2019
19 Reads

Preservation of femoral and tibial coronal alignment to improve biomechanical effects of medial unicompartment knee arthroplasty: Computational study.

Biomed Mater Eng 2018 ;29(5):651-664

Department of Orthopaedic Surgery, Joint Reconstruction Center, Yonsei Sarang Hospital, 10 Hyoryeong-ro, Seocho-gu, Seoul, 06698, Republic of Korea.

Background: Medial unicompartmental knee arthroplasty (UKA) could be concerned with wear of the cartilage or the wear in the polyethylene (PE) insert. Mechanical alignment determines the biomechanical effect in the long term. However, previous computational studies all found that femoral and tibial components alignment in the UKA were rare, and the results varied. Read More

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http://dx.doi.org/10.3233/BME-181015DOI Listing
February 2019
19 Reads

Loss of anisotropic properties in abdominal aorta aneurysm obtained from the xenograft rat model.

Biomed Mater Eng 2018 Oct;29(5):641-650

Bioengineering, Tissue and Neuroplasticity (BIOTN), Faculté de Médecine, Université Paris-Est Créteil, Créteil, France.

Background: Cellular treatments using mesenchymal stem cells (MSCs) cultured in 3D conditions constitute a solution to the classical surgery in treating abdominal aortic aneurysm (AAA). The recurrent question is: how this type of biotherapy changes the mechanical behavior of artery?

Methods: Experiments measurements based on xenograft rat model showed that the proposed cellular treatment leads to a decreasing radius and length of the AAA during its growth. An inverse finite element method was used to investigate the mechanical hyperelastic behavior of the AAA in the untreated case compared to the treated one. Read More

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http://dx.doi.org/10.3233/BME-181014DOI Listing
October 2018
3 Reads

An evaluation of the contact forces on the fingers when squeezing a spherical rehabilitation ball.

Biomed Mater Eng 2018 ;29(5):629-639

National Institute for Occupational Safety and Health, Morgantown, WV, USA.

The rehabilitation squeeze ball is a popular device to help strengthen the hand, fingers and forearm muscles. The distributions of the contact pressure in the interface between the therapy ball and hand/fingers can affect the joint moment of each of the individual fingers, thereby affecting rehabilitation effects. In the current study, we evaluated the contact force distributions on the fingers when gripping a spherical object. Read More

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http://dx.doi.org/10.3233/BME-181013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388416PMC
February 2019

Static and dynamic analyses of fracture fixation bone-plate systems for different plate materials and dimensions.

Biomed Mater Eng 2018 ;29(5):611-628

Department of Mechanical Engineering, Faculty of Engineering, Firat University, Elazig, Turkey.

Background: Various techniques have been developed in the treatment of fractures. One of these techniques is the internal fixation, which has an important place in practice.

Objective: In this study, fractured tibia bone has been treated with implants as numerically to investigate the stress behavior and the effect of plate material, shape and dimensions under pressure load. Read More

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http://dx.doi.org/10.3233/BME-181012DOI Listing
February 2019
1 Read

Effect of orientation and age on the crack propagation in cortical bone.

Biomed Mater Eng 2018 ;29(5):601-610

Department of Mechanical Engineering, FET, IIUI, H-10, Islamabad, Pakistan.

The crack propagation behavior near the initial crack were studied under the compact tension (CT) fracture toughness experiments test on bovine hip bone joint specimens. The bone specimens were prepared according to ASTM E-399 for plain fracture toughness tests. The specimens were cut from the hip joint both in the longitudinal and transverse direction to the collagen fiber orientation in the bone. Read More

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http://dx.doi.org/10.3233/BME-181011DOI Listing
February 2019
4 Reads

Novel smart clothing with dry electrode biosensor for real-time automatic diagnosis of cardiovascular diseases.

Biomed Mater Eng 2018 ;29(5):587-599

Department of Biomedical Engineering, School of Medicine, Keimyung University, Daegu, South Korea.

The incidence of heart disease increases with age. The typical method of monitoring arrhythmia is to use a body patch type sensor with a wet electrode. Even though this sensor is easy to use, it has several disadvantages such as problems caused by wet electrodes in tissues when they are monitored for long periods. Read More

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http://dx.doi.org/10.3233/BME-181010DOI Listing
February 2019

Biomaterials as cell carriers for augmentation of adipose tissue-derived stromal cell transplantation.

Biomed Mater Eng 2018 ;29(5):567-585

Department of Biochemistry and Applied Sciences, University of Miyazaki, Miyazaki 889-2162, Japan.

Adipose tissue-derived stromal cells (ADSCs) contain lineage-committed progenitor cells that have the ability to differentiate into various cell types that may be useful for autologous cell transplantation to correct defects of skin, adipose, cartilage, bone, tendon, and blood vessels. The multipotent characteristics of ADSCs, as well as their abundance in the human body, make them an attractive potential resource for wound repair and applications to tissue engineering. ADSC transplantation has been used in combination with biomaterials, including cell sheets, hydrogel, and three-dimensional (3D) scaffolds based on chitosan, fibrin, atelocollagen, and decellularized porcine dermis, etc. Read More

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http://dx.doi.org/10.3233/BME-181009DOI Listing
February 2019
12 Reads

Improving the performance of empirical mode decomposition via Tsallis entropy: Application to Alzheimer EEG analysis.

Biomed Mater Eng 2018 ;29(5):551-566

Department of Computer Engineering and Mathematics, University Rovira i Virgili, Tarragona, 43007, Spain.

Alzheimer is a degenerative disorder that attacks neurons, resulting in loss of memory, thinking, language skills, and behavioral changes. Computer-aided detection methods can uncover crucial information recorded by electroencephalograms. A systematic literature search presents the wavelet transform as a frequently used technique in Alzheimer's detection. Read More

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http://dx.doi.org/10.3233/BME-181008DOI Listing
February 2019
10 Reads

Regional pulse wave velocity and stress in aneurysmal arch-shaped aorta.

Biomed Mater Eng 2018 ;29(4):527-549

Department of Mechanical Engineering, Faculty of Engineering, Chiang Mai University, Chiang Mai, Thailand.

The pulse wave velocity (PWV) has been shown to be associated with the properties of blood vessel and a cardiovascular risk factor such as aneurysm. The global PWV estimation is applied in conventional clinical diagnosis. However, the geometry of blood vessel changes along the wave traveling path and the global PWV estimation may not always detect regional wall changes resulting from cardiovascular diseases. Read More

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http://dx.doi.org/10.3233/BME-181007DOI Listing
January 2018

Influence of different implant-abutment connections on stress distribution in single tilted implants and peripheral bone: A three-dimensional finite element analysis.

Biomed Mater Eng 2018 ;29(4):513-526

Department of Prosthodontics, Faculty of Dentistry, Ondokuz Mayıs University, Samsun, Turkey.

Background: The load transfer between the implant-bone interface depends on various factors, including loading type; material properties of the implant and prosthesis; and implant geometry, length, diameter, and shape.

Objective: The purpose of this study was to evaluate stress distribution in single tilted bone-level implants with different connections and peripheral bone under vertical and oblique loads using three-dimensional (3D) finite element analysis (FEA).METHOS. Read More

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http://dx.doi.org/10.3233/BME-181006DOI Listing
January 2018
8 Reads

Dynamic response and material sensitivity analysis of pelvic complex numerical model under side impact.

Biomed Mater Eng 2018 ;29(4):499-512

First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.

Background: The surrogate design and clinical diagnostic suggest that the pelvic dynamic response should be the basis of bone fracture mechanism study under side impact. Pelvic response indicators are the impact force, compression (C), viscous criterion (VC), bone stress, and bone strain. However, no evaluation of these indicators has been conducted. Read More

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http://dx.doi.org/10.3233/BME-181005DOI Listing
January 2018
15 Reads

Biomechanical evaluation of four surgical scenarios of lumbar fusion with hyperlordotic interbody cage: A finite element study.

Biomed Mater Eng 2018 ;29(4):485-497

Department of Mechanical Engineering, Tsinghua University, Beijing, China.

Background: Lumbar spinal fusion in the interbody space is augmented with interbody fusion cages to provide structural support while arthrodesis occurs. Subsidence is a serious complication of interbody fusion. However, the biomechanical influence of anterior longitudinal ligament (ALL) and pedicle screws on subsidence has not been fully understood. Read More

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http://dx.doi.org/10.3233/BME-181004DOI Listing
January 2018
1 Read

A finite element analysis for monitoring the healing progression of fixator-bone system under three loading conditions.

Biomed Mater Eng 2018 ;29(4):473-483

National Research Center for Rehabilitation Technical Aids, Beijing, China.

Background: Unilateral external fixators are widely used in orthopedics to stabilize fractured bones and in the treatment of limb deformities. The main value for evaluation of mechanical stability of the external fixator is fixator stiffness. The fixator stiffness is an important factor as it will influence the biomechanical environment to which fixator and regenerating tissues are exposed. Read More

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http://dx.doi.org/10.3233/BME-181003DOI Listing
January 2018
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Review of core-multishell nanostructured models for nano-biomedical and nano-biopharmaceutical application.

Biomed Mater Eng 2018 ;29(4):451-471

Department of Physics, Faculty of Sciences, University of Novi Sad, Vojvodina, Serbia.

The main advantage of a theoretical approach is essential knowledge of the mechanisms that allow us to comprehend the experimental conditions that we have to fulfill to be able to get the desired results. Based on our research in ultrathin crystal structures performed so far, superlattices, Q-wires and Q-dots, we will consider the materials that can act as carriers for medicines and tagged substances. For this purpose we established a shell-model of ultrathin crystals and investigated their fundamental characteristics. Read More

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http://dx.doi.org/10.3233/BME-181002DOI Listing
January 2018
3 Reads

Evaluation of swelling processes of various natural polymer matrix tablets by X-ray computed tomography and controlled drug release.

Biomed Mater Eng 2018 ;29(4):439-450

Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Tokyo, Japan.

Background: The swelling properties and the drug-release sustainability of pre-gelatinized starches (𝛼-starch) tablets depend on the polymer characteristics.

Objectbs: In order to clarify the drug release form, the natural polymers (NPs) were investigated. The relationship between drug release and swelling of natural polymers (NPs), the swelling processes of various starch polymers, were investigated using a drug-release test (DRT) and X-ray computed tomography (XCT). Read More

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http://dx.doi.org/10.3233/BME-181001DOI Listing
January 2018
14 Reads

Magnesium doping on TiN coatings affects mesenchymal stem cell differentiation and proliferation positively in a dose-dependent manner.

Biomed Mater Eng 2018 ;29(4):427-438

Genetics and Bioengineering Department, Yeditepe University, Istanbul, Turkey.

Background: In vitro evaluation of cell-surface interactions for hard tissue implants have mostly been done using osteoblasts. However, when an implant is placed in the body, mesenchymal stem cells (MSCs) play a major role in new bone formation. Therefore, using MSCs in cell-surface investigations may provide more reliable information on the prediction of in vivo behavior of implants. Read More

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http://dx.doi.org/10.3233/BME-181000DOI Listing
January 2018
2 Reads

Mechanical properties of cancellous tissue in compression test and nanoindentation.

Biomed Mater Eng 2018 ;29(4):415-426

Institute of Precision Mechanics, Warsaw, Poland.

The goal of the study was to determine material constants of cancellous tissue in a compression test taking into account stress-strain characteristics. The nineteen test samples were resected from a femoral head of a patient qualified for a hip replacement surgery. During the compression tests, load-displacement curves were evaluated and stress-strain characteristics (𝜎-𝜀) of the cancellous bone tissue were calculated. Read More

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http://dx.doi.org/10.3233/BME-180999DOI Listing
January 2018

Patient-specific design for articular surface conformity to preserve normal knee mechanics in posterior stabilized total knee arthroplasty.

Biomed Mater Eng 2018 ;29(4):401-414

Department of Mechanical Engineering, Yonsei University, Seoul, Republic of Korea.

Background: Contemporary total knee arthroplasty (TKA) provides remarkable clinical benefits. However, the normal function of the knee is not fully restored. Recent improvements in imaging and manufacturing have utilized the development of customized design to fit the unique shape of individual patients. Read More

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http://dx.doi.org/10.3233/BME-180998DOI Listing
January 2018
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Repeatability of small bowel transit time in capsule endoscopy in healthy subjects.

Biomed Mater Eng 2018 ;29(6):839-848

Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.

Background: There are no reports to prove the repeatability of gastric transit time (GTT) and small bowel transit time (SBTT) in capsule endoscopy (CE).

Objective: To clarify the repeatability and factors that affect GTT/SBTT in CE.

Methods: We analyzed the data of 150 healthy subjects from our previous randomized controlled trial that compared small intestinal injuries between two 14-day treatment groups: 1) celecoxib and 2) loxoprofen + lansoprazole. Read More

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http://dx.doi.org/10.3233/BME-181027DOI Listing
March 2019
8 Reads

Fluid-structure interaction simulation of ureter with vesicoureteral reflux and primary obstructed megaureter.

Biomed Mater Eng 2018 ;29(6):821-837

School of Industrial and Information Engineering, Polytechnic University of Milan, Milan, Italy.

Two common abnormalities in ureters include primary refluxing megaureter (PRM) and primary obstructed megaureter (POM). The aim of this study was to represent the numerical simulation of the urine flow at the end of the ureter with vesicoureteral reflux (VUR) and POM during peristalsis. Methodologically, the peristalsis in the ureter wall was created using Gaussian distribution. Read More

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http://dx.doi.org/10.3233/BME-181026DOI Listing
March 2019
14 Reads
0.850 Impact Factor

Nonthermal control of Escherichia coli growth using extremely low frequency electromagnetic (ELF-EM) waves.

Biomed Mater Eng 2018 ;29(6):809-820

Plant Pathology Department, Faculty of Agriculture, Cairo University, Egypt.

Background: Escherichia coli (E. coli) bacteria normally live in the intestines of people and animals. Most E. Read More

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http://dx.doi.org/10.3233/BME-181025DOI Listing

Tissue repair in neonatal and paediatric surgery: Analysis of infection in surgical implantation of synthetic resorbable biomaterials.

Biomed Mater Eng 2018 ;29(6):799-808

Department of Pediatric Surgery, Chelsea Children's Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, Imperial College London, UK.

Background: There has been increased interest in the use of biomaterials that resorb completely leaving only the patient's native tissue. Synthetic materials are advantageous for tissue repair because they are highly customisable. The infection rate of using resorbable natural materials in paediatric surgery has recently been outlined, but there has not yet been a review of the use of synthetic resorbable materials in paediatric surgery. Read More

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http://dx.doi.org/10.3233/BME-181024DOI Listing

Raman spectroscopic and fractal analysis of blood samples of dengue fever patients.

Biomed Mater Eng 2018 ;29(6):787-797

Department of Optoelectronics and Department of Nanoscience and Nanotechnology, University of Kerala, Trivandrum 695581, Kerala, India.

Background: The limitations of the existing techniques for the early detection of dengue fever necessitate the development of a powerful optical technique.

Objective: The present work is a study of Raman spectral modifications of blood on dengue infection and thereby to develop a spectroscopic method for its early detection. The images of the samples are subjected to fractal analysis to find the variation of fractal dimensions on dengue infection. Read More

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http://dx.doi.org/10.3233/BME-181023DOI Listing

Dopant-dependent tailoring of physicochemical and biological properties of calcium silicate bone cements.

Biomed Mater Eng 2018 ;29(6):773-785

Institute of Oral Science, Chung Shan Medical University, Taichung City 402, Taiwan.

Background: To enhance calcium silicate cements (CSCs) towards a specific clinical application of endodontics and vertebroplasty, the addition of oxide dopants (Bi2O3, SrO, ZnO, ZrO2) as radiopacifiers allows for tailoring of material properties.

Objective: Effects of oxide dopants on the in vitro physicochemical properties and osetogenic activity of CSCs were investigated.

Methods: The setting time, compressive strength, radiopacity, and osteogenic ability of the cements were evaluated. Read More

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http://dx.doi.org/10.3233/BME-181022DOI Listing
March 2019
2 Reads