44,086 results match your criteria Bilirubin Impaired Conjugation


Correlation and prognostic accuracy between noninvasive liver fibrosismarkers and portal pressure in cirrhosis: Role of ALBI score.

PLoS One 2018 12;13(12):e0208903. Epub 2018 Dec 12.

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: The role of noninvasive liver fibrosis markers which were developed to evaluate the severity of chronic liver disease remains unclear in cirrhosis.

Aims: To evaluate the correlation between noninvasive markers and hemodynamic parameters and their prognostic performance in cirrhotic patients.

Methods: A total of 242 cirrhotic patients undergoing hemodynamic study were analyzed. Read More

View Article
December 2018

Detection molecular of Rangelia vitalii in dogs from Parana State, Southern Brazil.

Rev Bras Parasitol Vet 2018 Dec 10. Epub 2018 Dec 10.

Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Paraná - UFPR, Curitiba, PR, Brasil.

Rangelia vitalii infects erythrocytes, leukocytes and endothelial cells of dogs. The present study aimed to report the molecular detection confirmed by sequencing of R. vitalii in the state of Paraná, as well as describe the clinical, hematological and biochemical alterations of the infected dogs. Read More

View Article
December 2018

Percutaneous transhepatic cholangial drainage combined with percutaneous endoscopic jejunostomy for maintaining nutrition state in patients with advanced ampullary neoplasms.

J Cancer Res Ther 2018 Dec;14(Supplement):S1158-S1162

Department of General Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, China.

Purpose: To investigate the role of percutaneous transhepatic cholangial drainage (PTCD) combined with percutaneous endoscopic jejunostomy (PEJ) in maintaining the nutrition state in patients with advanced ampullary neoplasms.

Materials And Methods: Sixty patients who suffered from advanced ampullary neoplasms and could not tolerate internal drainage operation or biliary stent placement were enrolled. After PTCD, PEJ was implemented, and then the enteral nutrient solution + bile were instilled through PEJ tube for enteral nutrition support. Read More

View Article
December 2018

Acute triflumuron exposure induces oxidative stress responses in liver and kidney of Balb/C mice.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

Triflumuron (TFM) is one of the most widely used insecticides over the world. It is a benzoylphenyl urea that belongs to the class of insect growth regulators. This insecticide acts by inhibiting insect's chitin synthesis and by consequences, making insect more susceptible to pathogens and malformations. Read More

View Article
December 2018

The potential protective effect of two actinomycete extracts against carbon tetrachloride-induced hepatotoxicity in rats.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

The aim of this study was to investigate the potential protective effect of two extracts derived from two soil actinomycete strains, designated S19 and G30, against CCl4-induced hepatotoxicity in male rats. Sixty-four male rats were divided into four groups of 16 rats per group. The first group was a control group given corn oil and the nutritive medium which is composed of a mixture of the two used media. Read More

View Article
December 2018

Placental Circulation Intact Trial (PCI-T)-Resuscitation With the Placental Circulation Intact vs. Cord Milking for Very Preterm Infants: A Feasibility Study.

Front Pediatr 2018 27;6:364. Epub 2018 Nov 27.

Department of Neuroscience, Psychology, Drug Research and Child Health, Careggi University Hospital of Florence, Florence, Italy.

Preterm newborns receiving briefly delayed cord clamping or cord milking at birth have better neonatal outcomes. However, the time frame in which both these procedures are performed (< 60 s of life) is too short to explore the possible beneficial effects on early infant postnatal adaptation and outcomes of a prolonged transfusion strategy associated with neonatal respiration. We have designed a randomized, multicenter, controlled two-phase study: phase 1 to assess the feasibility of carrying out the protocol in a large randomized trial, and phase 2 to assess the efficacy of bedside assistance with intact placental circulation for 3 min in comparison to cord milking to improve outcome in the neonatal period; we present here the feasibility and safety phase of the study. Read More

View Article
November 2018

Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats.

Stem Cells Int 2018 14;2018:7159465. Epub 2018 Nov 14.

Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Recent studies have described beneficial effects of an infusion of mesenchymal stem cells (MSCs) derived from Wharton's jelly tissue, for the treatment of acute liver failure (ALF). However, data on the therapeutic potential of culture-expanded MSCs are lacking. We examined the therapeutic potential of passage five (P5) and ten (P10) human umbilical cord- (hUC-) MSCs via their transplantation into Sprague-Dawley (SD) rats with D-galactosamine (D-GalN) and LPS-induced acute liver failure (ALF). Read More

View Article
November 2018

Clinical factors predicting drug-induced liver injury due to flucloxacillin.

Drug Healthc Patient Saf 2018 21;10:95-101. Epub 2018 Nov 21.

Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden,

Objectives: Drug-induced liver injury (DILI) is a serious adverse reaction due to flucloxacillin. The pathogenesis is not fully understood. Female sex, age over 60 years, and a longer treatment duration have been suggested to be predisposing factors. Read More

View Article
November 2018

Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles.

Int J Nanomedicine 2018 23;13:7931-7938. Epub 2018 Nov 23.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Objective: The objective of this study was to verify and confirm the oxidative-mediated hepatotoxicity, inflammatory liver damage, and oxidative stress induced by intraperitoneal administration of gold nanoparticles (GNPs) in vivo; characterize the effect of different natural antioxidants on these hazardous changes; and finally choose the most powerful antioxidant among these different natural antioxidants.

Methods: Ten-nanometer GNPs were dissolved in aqueous solution of 0.01% concentration. Read More

View Article
November 2018

Safety and Efficacy of Low-Dose Single-Agent Capecitabine in Inoperable Gallbladder Cancer with Jaundice Post-Single-System Single-Catheter External Biliary Drainage: a Pilot Study from a Highly Endemic Area.

Indian J Surg Oncol 2018 Dec 31;9(4):530-537. Epub 2018 Jul 31.

1Department of General Surgery, King George's Medical University, Lucknow, UP India.

Gallbladder cancer (CaGB) in the subcontinent belongs to low socioeconomic status, and at the time of diagnosis, a large number is unresectable or inoperable so the palliative treatment remains the only option. In the present study, attempt was made to see the effect and safety profile of single-agent oral capecitabine in inoperable CaGB in presence of low levels of jaundice post-single-catheter transhepatic external biliary drainage. In  = 35 of inoperable jaundiced CaGB, post-biliary drainage capecitabine in low dose was started when their total bilirubin levels fell to 10 mg% or below. Read More

View Article
December 2018

Therapeutic effect of hepatocyte growth factor-overexpressing bone marrow-derived mesenchymal stem cells on CCl-induced hepatocirrhosis.

Cell Death Dis 2018 Dec 11;9(12):1186. Epub 2018 Dec 11.

Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.

Hepatocirrhosis is one of the most severe complications of chronic hepatic disease in terms of medical intervention, and the available therapies are limited and not very successful. In this study, bone marrow-derived mesenchymal stem cells (BM-MSCs) from host rats were transduced with an adenoviral vector labelled with green fluorescent protein (EGFP) to overexpress hepatocyte growth factor (HGF). The therapeutic effect of these modified stem cells (HGF-BM-MSC group) transplanted intravenously into hepatocirrhosis model rats treated with CCl was evaluated using serological, biochemical and histological approaches. Read More

View Article
December 2018

Heme oxygenase-1 induction by hemin prevents oxidative stress-induced acute cholestasis in the rat.

Clin Sci (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Instituto de Fisiología Experimental (IFISE-CONICET) y Area Bioquímica Clínica, Facultad de Ciencias Bioquímicas y Farmacéuticas, UNR, Suipacha 570, Rosario, S2002LRL, Argentina

We previously demonstrated in and models that physiological concentrations of unconjugated bilirubin prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous bilirubin (BR) levels. This was achieved through the administration of hemin, an inducer of HO-1, the rate-limiting step in BR generation. Read More

View Article
December 2018

Bloodstream infections during post-cardiotomy extracorporeal membrane oxygenation: Incidence, risk factors, and outcomes.

Int J Artif Organs 2018 Dec 11:391398818817325. Epub 2018 Dec 11.

2 ECMO Team, IRCCS Policlinico San Donato, Milan, Italy.

Introduction:: Veno-arterial extracorporeal membrane oxygenation after heart surgery is a relatively common procedure. It is easily applicable but associated with a number of complications, including bloodstream infections. The aim of this study is to determine the current rate and the risk factors related to bloodstream infections acquired during post-cardiotomy veno-arterial extracorporeal membrane oxygenation. Read More

View Article
December 2018

Laboratory validation and field usability assessment of a point-of-care test for serum bilirubin levels in neonates in a tropical setting.

Wellcome Open Res 2018 23;3:110. Epub 2018 Nov 23.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, 63110, Thailand.

Screening and monitoring serum bilirubin (SBR) in neonates is crucial to prevent neonatal hyperbilirubinemia (NH)-associated morbidity and mortality worldwide. A lack of resources is often a barrier for measuring SBR in developing countries. Reliable, cost-effective, easy to use point-of-care (POC) SBR tests are needed. Read More

View Article
November 2018

Predictive Value of Age-Bilirubin-International Normalized Ratio-Creatinine Score in Short-Term Survival of Acute-on-Chronic Hepatitis B Liver Failure.

Cell Physiol Biochem 2018 11;51(5):2484-2495. Epub 2018 Dec 11.

Department of Hepatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, China.

Background/aims: The age-bilirubin-international normalized ratio-creatinine (ABIC) score, which is a predictive model commonly used for alcoholic hepatitis, has not yet been studied in acute-on-chronic hepatitis B liver failure (HBV-ACLF). We aimed to investigate the predictive value of the ABIC score in patients with HBV-ACLF.

Methods: This retrospective study involved 398 patients diagnosed with HBV-ACLF, who were divided into a training cohort of 305 patients and a validation cohort of 93 patients. Read More

View Article
December 2018

Validation of the albumin-indocyanine green evaluation model in patients with resected hepatocellular carcinoma and comparison with the albumin-bilirubin score.

J Hepatobiliary Pancreat Sci 2018 Dec 8. Epub 2018 Dec 8.

Department of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy.

Background: The albumin-indocyanine green evaluation (ALICE) model based on serum albumin and indocyanine retention rate, has been shown to be an effective method for predicting postoperative outcomes in hepatocellular carcinoma patients. Aim of the study was to validate the ALICE model in a large Western cohort of patients by comparing the Albumin-Bilirubin (ALBI) score and Child-Turcotte-Pugh (CTP) score.

Methods: A total of 400 patients who underwent hepatic resection from 01/2005 to 06/2016 at 3 centers were enrolled. Read More

View Article
December 2018

Population Pharmacokinetic Analysis of Decitabine in Pediatric Patients With Acute Myeloid Leukemia.

J Clin Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Established Products, Janssen Research & Development, Titusville, NJ, USA.

Dacogen, the formulated product of the pharmaceutically active agent decitabine (5 aza-2'-deoxycytidine), is approved for treatment of myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML). The current analysis was performed to characterize the pharmacokinetics of decitabine in pediatric patients with AML and evaluate their consistency with the PK in adult patients. A population pharmacokinetic model was developed by pooling decitabine concentration-time data from 5 adult (AML and MDS) and 2 pediatric (AML) studies. Read More

View Article
December 2018

Physiological changes after colorectal surgery suggest anastomotic leakage is an early event: a retrospective cohort study.

Colorectal Dis 2018 Dec 11. Epub 2018 Dec 11.

St Mark's Hospital, Watford Road, Harrow, Middlesex, HA1 3UJ.

Introduction: Anastomotic leakage (AL) is often identified 7-10 days after colorectal surgery. However, in retrospect, patients may have abnormalities evident much earlier. This study aims to identify the clinical time-point when AL occurs. Read More

View Article
December 2018

Regional Cerebral Oximetry as an Indicator of Acute Brain Injury in Adults Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation-A Prospective Pilot Study.

Front Neurol 2018 23;9:993. Epub 2018 Nov 23.

Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, United States.

Regional cerebral oxygen saturation (rScO2) measured by near-infrared spectroscopy (NIRS) can be used to monitor brain oxygenation in extracorporeal membrane oxygenation (ECMO). ECMO patients that develop acute brain injuries (ABIs) are observed to have worse outcomes. We evaluated the association between rScO2 and ABI in venoarterial (VA) ECMO patients. Read More

View Article
November 2018

Comparison of extracorporeal cellular therapy (ELAD) vs standard of care in a randomized controlled clinical trial in treating Chinese subjects with acute-on-chronic liver failure.

Hepat Med 2018 16;10:139-152. Epub 2018 Nov 16.

Department of Surgery, University of Chicago, Chicago, IL, USA.

Background: Preliminary evidence of safety and efficacy of an extracorporeal cellular therapy (ELAD) has been demonstrated in subjects with acute forms of liver failure. This study compared ELAD with standard of care in Chinese subjects with acute-on-chronic liver failure (ACLF), predominantly secondary to chronic viral hepatitis.

Subjects And Methods: Subjects meeting eligibility criteria were randomized to either the ELAD group or the control group. Read More

View Article
November 2018

[Comparative analysis of side-by-side antegrade stenting and Y-biliary stenting for malignant biliary stricture].

Khirurgiia (Mosk) 2018 (11):20-23

Botkin Municipal Clinical Hospital, Moscow, Russia.

In the time period from 2009 to 2017 in Botkin Hospital (Moscow) bilateral biliary stenting was performed in 43 patients with malignant common hepatic duct stricture. Patients were divided into 2 statistically homogeneous groups: 'side-by-side' stenting in 28 patients and percutaneous 'Y'-biliary stent placement in 15 patients. The causes of malignant obstruction were as follows: in the 1 group 13 (46. Read More

View Article
January 2018
1 Read

[Malignant obstructive jaundice management via external biliary drainage followed by bile examination].

Khirurgiia (Mosk) 2018 (10):44-50

South Ural State Medical University of Healthcare Ministry of the Russian Federation, Chelyabinsk, Russia.

Aim: To determine optimal terms of biliary decompression and bile reinfusion into gastrointestinal tract in patients with malignant obstructive jaundice.

Material And Methods: 179 medical records of patients with obstructive jaundice were analyzed to identify risk factors of postoperative complications. Prospective research included bile examination in 34 patients with malignant obstructive jaundice. Read More

View Article
January 2018

G3 sports supplement in short triathlon: improvements in training, performance, recovery and oxidative stress.

Minerva Med 2018 Dec;109(6):451-456

CH-PE University, Irvine 3 Labs, Chieti, Italy.

Background: This registry study evaluated the effects of G3 Sports supplement drink (G3) on performance and endurance in triathlon in amateur athletes in a period of 2 weeks of training. G3 is composed of a proprietary fruit juice blend high in carotenoid compounds as well as 100 mg of standardized French oak (Quercus robur) wood extract, Robuvit®, per 50 mL bottle. The antioxidant and anti-inflammatory actions of the compounds in G3 may improve training efficiency (decreasing post-triathlon muscular pain, cramps and improve recovery time) and decrease post-training plasma free radicals (PFR). Read More

View Article
December 2018

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.

Drug Metab Pharmacokinet 2018 Sep 20. Epub 2018 Sep 20.

Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. Electronic address:

This study aimed to elucidate the impact of OATP1B1 genotype (*1b/*1b, *1b/*15, and *15/*15) on plasma concentrations of endogenous OATP1B1 substrates. Healthy volunteers with OATP1B1 *1b/*1b (n = 10), *1b/*15 (n = 7), or *15/*15 (n = 2) received oral administration of a cocktail of statins (atorvastatin, pitavastatin, rosuvastatin, and fluvastatin). Mean area under the plasma concentration of atorvastatin, pitavastatin, and rosuvastatin in OATP1B1 *15/*15 were 2. Read More

View Article
September 2018

Effect of Hyperbilirubinemia on Hepatic Hypertrophy after Portal Vein Embolization and Liver Failure after Heatectomy in Primary Biliary Malignancy.

J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Kyungpook National University School of Medicine, Daegu, Korea.

Purpose: To retrospectively investigate the impact of hyperbilirubinemia on future liver remnant (FLR) volume after percutaneous transhepatic portal vein embolization (PVE) and incidence of post-hepatectomy liver failure in primary biliary malignancy.

Materials And Methods: Eighty-seven patients (62 men, overall mean age 66.9 y) who underwent PVE, using Gelfoam and coils before major hepatectomy between January 2004 and June 2016, were included in this study and divided into a hyperbilirubinemia (serum total bilirubin level at PVE 5. Read More

View Article
December 2018

Clinical characteristics and prognosis of HCC occurrence after antiviral therapy for HCV patients between sustained and non-sustained responders.

J Formos Med Assoc 2018 Dec 4. Epub 2018 Dec 4.

Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background: Hepatitis C virus (HCV)-infected patients who achieved sustained virologic response (SVR) may still develop hepatocellular carcinoma (HCC). The characteristic of HCC and the prognosis between SVR and non-SVR patients were not well known.

Methods: Among 1884 HCV-infected patients who were treated with pegylated IFN plus ribavirin therapies, 122 patients developed HCC during follow-up were enrolled in this study. Read More

View Article
December 2018
1 Read

Developing a Novel Ambulatory Total Parenteral Nutrition-Dependent Short Bowel Syndrome Animal Model.

J Surg Res 2019 Feb 27;234:13-19. Epub 2018 Sep 27.

Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri. Electronic address:

Background: Short bowel syndrome (SBS) results from extensive bowel resection. Patients with SBS require total parenteral nutrition (TPN) for survival. Understanding mechanisms contributing to TPN-associated liver injury and gut atrophy are critical in developing SBS therapies. Read More

View Article
February 2019

Vasoplegia after implantation of a continuous flow left ventricular assist device: incidence, outcomes and predictors.

BMC Anesthesiol 2018 Dec 8;18(1):185. Epub 2018 Dec 8.

Anaesthesiologist, Section of Anaesthesia, Pain Medicine and Intensive Care, Imperial College, London, UK.

Background: Vasoplegia after routine cardiac surgery is associated with severe postoperative complications and increased mortality. It is also prevalent in patients undergoing implantation of pulsatile flow left ventricular assist devices (LVAD). However, less is known regarding vasoplegia after implantation of newer generations of continuous flow LVADs (cfLVAD). Read More

View Article
December 2018

D-T7 Peptide Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Antiangiogenesis and Chemotherapy of Glioma.

ACS Appl Mater Interfaces 2018 Dec 10. Epub 2018 Dec 10.

The blood brain tumor barrier (BTB) and blood-brain barrier (BBB) have always been the major barriers in the treatment of glioma. In this report, we proposed D-T7 peptide modified nanoparticles actively targeted glioma by overcoming the BBB and BTB to improve the anti-glioma efficacy. Glioma targeting experiment showed that the penetration effect of D-T7 peptide modified nanoparticles was 7. Read More

View Article
December 2018

Outcomes Analysis of Children Diagnosed With Hemophagocytic Lymphohistiocytosis in the PICU.

Pediatr Crit Care Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Critical Care, Children's National Health System, Washington, DC.

Objectives: Describe a single center experience of hemophagocytic lymphohistiocytosis in a PICU over a 10-year period, to identify clinical features that may be associated with worse outcomes, including mortality, hospital and ICU length of stay, and functional and cognitive impairments on discharge.

Design: Retrospective electronic medical record review, 2007-2017.

Setting: PICU located in a large urban academic quaternary care children's hospital. Read More

View Article
December 2018
1 Read

Effect of metoclopramide administration to mothers on neonatal bilirubin and maternal prolactin: a randomized, controlled, clinical trial.

World J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

Department of Midwifery, Students Research Committee, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Jaundice is a common neonatal problem. This study was conducted to determine the effect of metoclopramide on neonatal bilirubin and maternal prolactin (primary outcomes) and milk volume (secondary outcome).

Methods: This triple-blind, randomized, controlled, clinical trial was conducted on 112 mothers. Read More

View Article
December 2018

High unbound bilirubin for age: a neurotoxin with major effects on the developing brain.

Pediatr Res 2018 Dec 5. Epub 2018 Dec 5.

Keck School of Medicine of University of Southern California, Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center, Los Angeles, CA, USA.

Neonatal hyperbilirubinemia is one of the most frequent diagnoses made in neonates. A high level of unconjugated bilirubin that is unbound to albumin is neurotoxic when the level exceeds age-specific thresholds or at lower levels in neonates with neurotoxic risk factors. Lower range of unbound bilirubin results in apoptosis, while moderate-to-high levels result in neuronal necrosis. Read More

View Article
December 2018
1 Read

Demographic and facility volume related outcomes in radiofrequency ablation for early-stage hepatocellular carcinoma.

HPB (Oxford) 2018 Dec 3. Epub 2018 Dec 3.

University of California, Irvine School of Medicine, Department of Radiological Sciences, 101 The City Drive South, Orange, CA 92868, USA.

Background: To evaluate outcomes related to disparities in facility volume and patient demographics in patients with early-stage hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA).

Methods: This is a retrospective study of patients with stage I/II HCC treated with RFA in the National Cancer Database. Independent contributors to overall survival were determined with Cox regression analysis. Read More

View Article
December 2018

Five-year native liver survival analysis in biliary atresia from a single large Chinese center: The death/liver transplantation hazard change and the importance of rapid early clearance of jaundice.

J Pediatr Surg 2018 Oct 30. Epub 2018 Oct 30.

General Surgery Department of Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, 56# Nanlishi Road, Beijing, China. Electronic address:

Purpose: This study aimed to analyze the change of death/liver transplantation hazard and biochemical indexes over time after Kasai procedure (KP) based on a retrospective biliary atresia (BA) cohort, and to evaluate the predictive value of early jaundice clearance rate to 5-year native liver survival (NLS).

Methods: A retrospective cohort with follow-up results of 139 BA patients from January 2009 to December 2012 was established, and the pre- and postoperative data were collected. NLS rates were estimated with Kaplan-Meier curves, and any differences between groups were tested by log-rank test. Read More

View Article
October 2018

Increased plasma levels of the lipoperoxyl radical-derived vitamin E metabolite α-tocopheryl quinone are an early indicator of lipotoxicity in fatty liver subjects.

Free Radic Biol Med 2018 Nov 30;131:115-125. Epub 2018 Nov 30.

Department of Pharmaceutical Science, University of Perugia, Perugia, Italy. Electronic address:

Lipid peroxidation is one of the earliest pathogenic events of non-alcoholic fatty liver disease (NAFLD). In this context, an increased oxidation of the lipoperoxyl radical scavenger α-tocopherol (α-TOH) should occur already in the subclinical phases of the disease to compensate for the increase oxidation of the lipid excess of liver and possibly of other tissues. However, this assumption remains unsupported by direct analytical evidence. Read More

View Article
November 2018

Human AHR functions in vascular tissue: Pro- and anti-inflammatory responses of AHR agonists in atherosclerosis.

Authors:
Karl Walter Bock

Biochem Pharmacol 2018 Dec 1;159:116-120. Epub 2018 Dec 1.

Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Wilhelmstrasse 56, D-72074 Tübingen, Germany. Electronic address:

Despite decades of intense research physiologic aryl hydrocarbon receptor (AHR) functions have not been elucidated. Challenges include marked species differences and dependence on cell type and cellular context. A previous commentary on human AHR functions in skin and intestine has been extended to vascular tissue. Read More

View Article
December 2018

Acute liver failure in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots.

J Vet Emerg Crit Care (San Antonio) 2018 Dec 2. Epub 2018 Dec 2.

University Veterinary Teaching Hospital, Sydney, Australia.

Objective: To describe the management and resolution of acute liver failure (ALF) in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots.

Case Summaries: A 2-year-old male entire Bullmastiff and a 5-year-old female neutered German Shepherd dog were presented for acute-onset lethargy and vomiting after chewing on tree roots of a cheese tree. Both dogs developed clinical abnormalities consistent with ALF, including hepatic encephalopathy, marked increase in alanine aminotransferase activity and bilirubin concentration, and prolonged coagulation times. Read More

View Article
December 2018
1 Read

Optimization of heart allocation: The transplant risk score.

Am J Transplant 2018 Dec 2. Epub 2018 Dec 2.

Agence de la Biomédecine Direction Prélèvement Greffe Organes-Tissus, Saint-Denis La Plaine, France.

The new French heart allocation system is designed to minimize waitlist mortality and extend the donor pool without a detrimental effect on post-transplant survival. This study was designed to construct a 1-year post-transplant graft-loss risk score incorporating recipient and donor characteristics. The study included all adult first single-organ recipients transplanted between 2010 and 2014 (N=1776). Read More

View Article
December 2018
1 Read

Hepatoprotective activity of praecoxin A isolated from Melaleuca ericifolia against carbon tetrachloride-induced hepatotoxicity in mice. Impact on oxidative stress, inflammation, and apoptosis.

Phytother Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

The hepatoprotective activity of praecoxin A, an ellagitannin from Melaleuca ericifolia, was determined against CCl -induced toxicity in mice. Praecoxin A was administered (25, 50, and 100 mg/kg) for 5 days followed by CCl . Praecoxin A markedly ameliorated the CCl -induced increase in AST (by 19, 52, and 56%), ALP (22, 45, and 48%), ALT (11, 47, and 54%), total bilirubin (14, 27, and 28%), and MDA (26, 44, and 51%) at the tested doses, respectively, as compared with CCl group. Read More

View Article
December 2018
3 Reads

[Preliminary report on prospective, multicenter, open research of selective surgery after expandable stent combined with neoadjuvant chemotherapy in the treatment of obstructive left hemicolon cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1233-1239

Department of General Surgery, The Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China.

Objective: To evaluate the safety and feasibility of neoadjuvant chemotherapy prior elective surgery following self-expanding metallic stents (SEMS) for complete obstructive left hemicolon cancer.

Methods: This prospective, multicenter, open-labelled trial was approved by the Ethics Committee of Beijing Chaoyang Hospital, Capital Medical University(2016-ke-161-1) and registered in Clinicaltrials.gov (NCT02972541). Read More

View Article
November 2018
2 Reads

Study of Percutaneous Stent Placement with Iodine-125 Seed Strand for Malignant Biliary Obstruction.

Cardiovasc Intervent Radiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Gulou District, Nanjing, 210029, China.

Purpose: To evaluate the effectiveness and safety of simultaneous placement of a self-expandable metallic stents (SEMS) and iodine-125 seed strand in the management of malignant obstructive jaundice (MOJ).

Materials And Methods: This study included 132 patients with MOJ treated from November 2015 to October 2017. Forty-five patients underwent insertion of SEMS with iodine-125 seed strands (Seeds group); the remaining 87 patients underwent SEMS placement alone (Control group). Read More

View Article
November 2018

Using the Albumin-Bilirubin (ALBI) grade as a prognostic marker for radioembolization of hepatocellular carcinoma.

J Gastrointest Oncol 2018 Oct;9(5):840-846

Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA.

Background: The Child-Pugh (CP) class is a commonly used scoring system to measure liver function in patients with hepatocellular carcinoma (HCC). We correlate the Albumin-Bilirubin (ALBI) grading system and CP to overall survival in our HCC patients receiving radioembolization.

Methods: We retrospectively evaluated patients who received radioembolization for HCC between the years 2009-2014. Read More

View Article
October 2018

Delayed bilhemia complicating percutaneous transhepatic biliary drainage: Successful treatment with primary coil embolization.

Radiol Case Rep 2019 Feb 27;14(2):269-272. Epub 2018 Nov 27.

Department of Diagnostic and Interventional Radiology, Istanbul Training and Research Hospital, Istanbul, 34098, Turkey.

Bilhemia is very rare and serious complication of percutaneous transhepatic biliary drainage (PBD). Bile leakage occurs into the bloodstream through a fistula between the biliary tree and the hepatic venous system. We report a case of a 45-year-old woman with bilhemia complicated by PBD. Read More

View Article
February 2019
1 Read

Blueberry extract attenuates γ-radiation-induced hepatocyte damage by modulating oxidative stress and suppressing NF-κB in male rats.

Saudi J Biol Sci 2018 Nov 4;25(7):1272-1277. Epub 2018 Jul 4.

Biochemistry Department, Science Faculty in Alsolimania, King Abdulaziz University, Saudi Arabia.

Radiation exposure is known to produce many harmful effects in biological systems, and these effects are often mediated by oxygen free radicals. Because blueberries are rich in antioxidant compounds such as anthocyanins and phenolic acids, we divided forty adult rats into four treatment groups of 10 (G1-4) as follows: G1 rats were used as a control, G2 rats were irradiated with 8 Gy at 2 Gy/week at a dose rate of 0.5 Gy/min, G3 rats were administered blueberry extract (200 mg/kg) and G4 rats were administered blueberry extract during the same irradiation period. Read More

View Article
November 2018
1 Read

Modifications to Expose Porta Hepatis for Laparoscopic Portoenterostomy Easier in Biliary Atresia.

J Surg Res 2019 Jan 10;233:368-375. Epub 2018 Sep 10.

Department of General surgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, China.

Background: Laparoscopic Kasai portoenterostomy (LKPE) is generally regarded to have a poorer outcome for surgical treatment of uncorrectable biliary atresia. We herein described our initial experience of some modifications to make LKPE easier in the treatment of type III biliary atresia (BA).

Methods: During the period July 2012-October 2016, a total of 25 infants with type III BA were treated with a modified LKPE technique. Read More

View Article
January 2019
2 Reads

Laparoscopic Cholecystectomy is Safe Both Day and Night.

J Surg Res 2019 Jan 24;233:163-166. Epub 2018 Aug 24.

Division of Burns, Department of Surgery, Trauma and Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: It is reported that performing laparoscopic cholecystectomy (LC) at night leads to increased rates of complications and conversion to open. We hypothesize that it is safe to perform LC at night in appropriately selected patients.

Materials And Methods: We performed a retrospective review of nonelective LC in adults at our institution performed between April 2007 and February 2015. Read More

View Article
January 2019
1 Read

Biliary atresia: 20-40-year follow-up with native liver in an Italian centre.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatric Surgery, "Spedali Civili" Children's Hospital, 25123, Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, 25123, Brescia, Italy.

Introduction: Biliary atresia (BA) represents the leading indication for liver transplantation in childhood. Only few studies reported the outcome of patients who survived more than 20 years on their native liver, and up to date there are no Italian data available. We reported our 40-year single centre experience with long-term follow-up of BA patients. Read More

View Article
November 2018
2 Reads