71,738 results match your criteria Biliary Disease


Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis.

Viral Immunol 2021 May 13. Epub 2021 May 13.

Department of Ophthalmology and Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a marked tropism for the biliary tract; it damages the bile ducts and hepatocytes and can lead to liver decompensation, cirrhosis, and sepsis. The pathogenesis of liver damage and its association with damage to the lung, heart, and brain and to the other protean manifestations of COVID-19 disease are not fully understood. In particular, tissue damage from thinning and leaky blood vessels appears to result from an inflammatory response to the virus rather than the virus itself. Read More

View Article and Full-Text PDF

Outcomes of Pediatric Liver Transplantation in Japan: A Report from the Registry of the Japanese Liver Transplantation Society (JLTS).

Transplantation 2021 Jan 19. Epub 2021 Jan 19.

1. Transplantation Center, National Center for Child Health and Development, Tokyo, Japan 2. Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan 3. Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan 4. Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan 5. Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan 6. Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan 7. Department of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan 8. Department of Hepato-Pancreatic-Biliary and Breast Surgery, Ehime University Graduate School of Medicine, Ehime, Japan 9. Department for the Promotion of Regional Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan 10. Shiga Medical University, Shiga, Japan 11. Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Background: The Japanese Liver Transplantation Society (JLTS), a cooperative research consortium, was established in 1980 in order to characterize and follow trends in patient characteristics and graft survival among all liver transplant patients in Japan. This study analyzed factors that may affect the current outcomes of pediatric patients who undergo LT by evaluating one of the largest pediatric LT cohorts in the world.

Methods: Between November 1989 and December 2018, 3347 pediatric patients underwent LT in Japan. Read More

View Article and Full-Text PDF
January 2021

An Assessment of Combination of the Camrelizumab With Chemotherapy in Metastatic Biliary Tract Cancers.

Cancer Control 2021 Jan-Dec;28:10732748211017165

Department of Oncology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.

Background: Monoclonal antibodies that target the PD-1 receptor are emerging as promising therapeutic candidates for the treatment of biliary tract cancers (BTCs). The purpose of the current study was to assess the combination of the camrelizumab with chemotherapy as a first-line treatment for metastatic BTCs.

Methods: We conducted a prospective single-arm pilot study of PD-1 antibody (camrelizumab 3 mg/kg d1, Q2 W or Q3 W) combined with different chemotherapy regimens as first-line treatment for BTCs. Read More

View Article and Full-Text PDF

Invited Commentary: Optimization of the Management of Elderly Patients with Acute Complicated Calculous Biliary Disease is Feasible.

Authors:
T Codjia L Schwarz

World J Surg 2021 May 12. Epub 2021 May 12.

Department of Digestive Surgery, Rouen University Hospital, 1 rue de Germont, 76031, Rouen cedex, France.

View Article and Full-Text PDF

Laparoscopic Cholecystectomy for Gallbladder Dysfunction and Polyps: Incidence and Follow up.

JSLS 2021 Apr-Jun;25(2)

University Hospital Hairmyres, Lanarkshire, Scotland, UK.

Aim: This study aims to evaluate the incidence, indications, management, and long term follow up of cholecystectomy in patients with no gallstones, other than acalculous acute cholecystitis.

Methods: Prospectively collected data of 5675 patients undergoing laparoscopic cholecystectomy (LC) over 28 years was extracted and analyzed. Patients with biliary symptoms, no stones on ultrasound scans and abnormal hepatobiliary iminodiacetic acid scans, and those with confirmed gallbladder polyps (GBP) were included. Read More

View Article and Full-Text PDF

Validating a novel algorithm to identify patients with autoimmune hepatitis in an administrative database.

Pharmacoepidemiol Drug Saf 2021 May 12. Epub 2021 May 12.

Department of Medicine, Division of Digestive Health and Liver Disease, University of Miami Miller School of Medicine, Miami, FL.

Purpose: Population-level studies on the treatment practices and comparative effectiveness of therapies in autoimmune hepatitis (AIH) are lacking due to the absence of validated methods to identify patients with AIH in large databases, such as administrative claims or electronic health records. This study ascertained the performance of International Classification of Diseases (ICD) codes for AIH, and developed and validated a novel algorithm that reliably identifies patients with AIH in health administrative data and claims.

Methods: This was a cross-sectional study of patients with ≥1 inpatient or ≥2 outpatient ICD codes for AIH between 2008-2019 at a single health system. Read More

View Article and Full-Text PDF

Cholangiocyte Organoids as a Cell Source for Biliary Repair.

Transpl Int 2021 May 11. Epub 2021 May 11.

Department of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Preoccupied with the astounding regenerative capabilities and metabolic importance of hepatocytes in the liver, the role of the resident "plumbers" of the liver, the cholangiocytes, can be overlooked in comparison. Cholangiocytes form the ductal network which makes up the biliary tree and transports bile from the liver to the gallbladder for secretion into the intestine during digestion. Chronic accumulation of bile in the liver is cytotoxic, causing fibrosis and eventually leads to cirrhosis and liver failure. Read More

View Article and Full-Text PDF

MicroRNA-34a Promotes EMT and Liver Fibrosis in Primary Biliary Cholangitis by Regulating TGF-1/smad Pathway.

J Immunol Res 2021 23;2021:6890423. Epub 2021 Apr 23.

Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background And Aims: Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease. We found microRNA-34a (miR-34a), as the downstream gene of p53, was overexpressed in some of fibrogenic diseases. In this study, we sought to explore whether miR-34a plays a role in the fibrosis of PBC. Read More

View Article and Full-Text PDF

What Can Be Done to Solve the Unmet Clinical Need of Hepatocellular Carcinoma Patients following Lenvatinib Failure?

Liver Cancer 2021 Apr 25;10(2):115-125. Epub 2021 Feb 25.

Hepato-biliary Center, Matsuyama Red Cross Hospital, Matsuyama, Japan.

Background/aim: An effective postprogression treatment of lenvatinib (LEN) against unresectable hepatocellular carcinoma (u-HCC) has not been established. We aimed to elucidate the clinical role of continuing LEN beyond progression of disease (PD).

Methods: From March 2018 to October 2020, 99 u-HCC patients, in whom PD was confirmed (male:female = 78:21, median age 72 years, Child-Pugh A = 99, Barcelona Clinic Liver Cancer stage A:B:C = 2:43:54, LEN as first-line = 55), were enrolled (stopped LEN at PD [A group], = 26; continued LEN beyond PD [B group], = 73). Read More

View Article and Full-Text PDF

Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP).

Gut 2021 May 11. Epub 2021 May 11.

Division of Gastroenterology and Hepatology, National University Hospital, Singapore

Objective: To investigate the incidence of gastric cancer (GC) attributed to gastric intestinal metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for targeted endoscopic surveillance in regions with low-intermediate incidence of GC.

Methods: A prospective, longitudinal and multicentre study was carried out in Singapore. The study participants comprised 2980 patients undergoing screening gastroscopy with standardised gastric mucosal sampling, from January 2004 and December 2010, with scheduled surveillance endoscopies at year 3 and 5. Read More

View Article and Full-Text PDF

Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study.

HPB (Oxford) 2021 Apr 28. Epub 2021 Apr 28.

Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Background: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA.

Methods: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000-2020). Read More

View Article and Full-Text PDF

Analysis of Pediatric Surgery Using the National Healthcare Insurance Service Database in Korea: How Many Pediatric Surgeons Do We Need in Korea?

J Korean Med Sci 2021 May 10;36(18):e116. Epub 2021 May 10.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: In the past, general surgeons (GSs) without a pediatric surgical subspecialty often performed surgery on children and, even now, GSs are performing many pediatric surgeries. We aimed to investigate the involvement of pediatric surgeons (PSs) and GSs in pediatric surgery, compare the outcomes of surgery in the neonatal intensive care unit (NICU), and estimate the appropriate PS workforce in Korea.

Methods: We used surgical data from the National Health Insurance Service database that was collected from patients under the age of 19 years in hospitals nationwide from January 2002 to December 2017. Read More

View Article and Full-Text PDF

Practical approach for the diagnosis of biliary atresia on imaging, part 2: magnetic resonance cholecystopancreatography, hepatobiliary scintigraphy, percutaneous cholecysto-cholangiography, endoscopic retrograde cholangiopancreatography, percutaneous liver biopsy, risk scores and decisional flowchart.

Pediatr Radiol 2021 May 11. Epub 2021 May 11.

APHM, Equipe d'Accueil 3279 - IFR 125, Service d'Imagerie Pédiatrique et Prénatale, Hôpital Timone Enfants, Aix Marseille Univ, Marseille, France.

We aim to present a practical approach to imaging in suspected biliary atresia, an inflammatory cholangiopathy of infancy resulting in progressive fibrosis and obliteration of extrahepatic and intrahepatic bile ducts. Left untreated or with failure of the Kasai procedure, biliary atresia progresses to biliary cirrhosis, end-stage liver failure and death within the first years of life. Differentiating biliary atresia from other nonsurgical causes of neonatal cholestasis is difficult as there is no single method for diagnosing biliary atresia and clinical, laboratory and imaging features of this disease overlap with those of other causes of neonatal cholestasis. Read More

View Article and Full-Text PDF

Automated Intact Glycopeptide Enrichment Method Facilitating Highly Reproducible Analysis of Serum Site-Specific N-Glycoproteome.

Anal Chem 2021 May 11. Epub 2021 May 11.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, China.

Bottom-up proteomics has been increasingly applied in clinical research to study the disease pathophysiology and to discover disease biomarkers. However, glycoproteomic analysis always requires tedious experimental steps for intact glycopeptide enrichment, which has been the technique bottleneck for large-scale analysis of clinical samples. Herein, we developed an automated glycopeptide enrichment method for the analysis of serum site-specific N-glycoproteome. Read More

View Article and Full-Text PDF

Laparoscopic partial liver resection for hepatocellular carcinoma arising from Fontan-associated liver disease: a case report.

Surg Case Rep 2021 May 10;7(1):115. Epub 2021 May 10.

Department of Hepato-Biliary-Pancreatic and Breast Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

Background: The Fontan procedure (FP) is a palliative surgery for functional single ventricle. The Fontan circulation maintains pulmonary circulation by a high central venous pressure, leading to chronic congestive liver. The number of patients diagnosed with hepatocellular carcinoma (HCC) arising from liver fibrosis and cirrhosis after FP is increasing. Read More

View Article and Full-Text PDF

Biliary Tree Cysts and Surgical Treatment: Outcomes in a Multicentric Study.

J Laparoendosc Adv Surg Tech A 2021 May 7. Epub 2021 May 7.

Division of Hepato-biliary-pancreatic Surgery, Department of Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain.

Biliary tree cysts (BTCs) represent an either localized or multifocal abnormal dilatation of the biliary tree, which entails an increased risk of acute cholangitis and cholangiocarcinoma (2.5%-16%). Its incidence in Western countries is ∼1/100. Read More

View Article and Full-Text PDF

Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2 Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction.

Front Med (Lausanne) 2021 22;8:603374. Epub 2021 Apr 22.

Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.

The recent coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2. COVID-19 was first reported in China (December 2019) and is now prevalent across the globe. Entry of severe acute respiratory syndrome coronavirus 2 into mammalian cells requires the binding of viral Spike (S) proteins to the angiotensin-converting enzyme 2 receptor. Read More

View Article and Full-Text PDF

Acute Pancreatitis in Children: The Clinical Profile at a Tertiary Hospital.

Cureus 2021 May 6;13(5):e14871. Epub 2021 May 6.

Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, BHR.

Objectives The clinical course and progression of acute pancreatitis are poorly understood to date, necessitating more studies of clinical profiles during the disease. Moreover, understanding the etiologies and clinical presentations of acute pancreatitis (AP) in children can contribute to early diagnosis and, hence, earlier interventions. Therefore, this article aims to study the clinical profiles of children with acute pancreatitis (AP) in relation to complications and other variables. Read More

View Article and Full-Text PDF

Safety of perioperative hyperthermic intraperitoneal chemotherapy with gemcitabine in patients with resected pancreatic adenocarcinoma: a pilot study of the clinical trial EudraCT 2016-004298-41.

J Gastrointest Oncol 2021 Apr;12(Suppl 1):S80-S90

Department of Surgery, University General Hospital, Ciudad Real, Faculty of Medicine, Ciudad Real, University of Castilla-La Mancha, Castilla La Mancha, Spain.

Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) with gemcitabine, after cytoreductive surgery, may reduce the tumor progression of pancreatic cancer through the reduction of the neoplastic volume and the subpopulation of residual pancreatic cancer stem cells, improving the survival of patients with pancreatic cancer and decreasing the recurrence of the disease.

Methods: A pilot study is performed with the first ten patients in the experimental group. A randomized study (phase II-III clinical trial) that requires a population of 42 patients, with 21 patients in each group. Read More

View Article and Full-Text PDF

Targeted therapies for gallbladder cancer: an overview of agents in preclinical and clinical development.

Expert Opin Investig Drugs 2021 May 8. Epub 2021 May 8.

Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases,IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Introduction: Gallbladder Cancer (gc) Is A Rare Malignancy With A Dismal Prognosis. If It Is Diagnosed Early Enough, It Can Be Cured By Surgical Removal. Unfortunately, Only A Small Gc Patient Population Can Be Amenable To Surgery, Though, With A High Relapse Rate. Read More

View Article and Full-Text PDF

Incidence of Hepatocellular Carcinoma in Patients with Non-alcoholic Fatty Liver Disease: A Systematic Review, Meta-analysis, and Meta-regression.

Clin Gastroenterol Hepatol 2021 May 6. Epub 2021 May 6.

Division of Abdominal and Transplantation Surgery, Department of Surgery, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; Hepato-pancreato-biliary Centre, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. Electronic address:

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) may be a risk factor for hepatocellular carcinoma (HCC), but the extent of this association still needs to be addressed. Pooled-incidence rates of HCC across the disease spectrum of NAFLD have never been estimated by meta-analysis.

Methods: In this systematic review, we searched Web of Science, Embase, Pubmed, and the Cochrane library from January 1, 1950 through July 30, 2020. Read More

View Article and Full-Text PDF

Clinical utility of methionyl-tRNA synthetase 1 immunostaining in cytologic brushings of indeterminate biliary strictures: a multicenter prospective study.

Gastrointest Endosc 2021 May 6. Epub 2021 May 6.

Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine. Electronic address:

Background And Aims: Endobiliary brushings are routinely used in the diagnosis, treatment, and prognostication of biliary strictures. However, standard Papanicolaou (Pap) staining has a low sensitivity in this setting, and the accuracy of brush cytology has not been established for indeterminate strictures. We therefore evaluated the diagnostic merit of methionyl-tRNA synthetase 1 (MARS1) immunofluorescence (IF) staining in such cytologic specimens. Read More

View Article and Full-Text PDF

Indication of Liver Transplantation in the Treatment of Newly Categorized Acute-on-Chronic Liver Failure In Japan.

Transplant Proc 2021 May 5. Epub 2021 May 5.

Department of Surgery, Division of Hepato-Biliary and Pancreatic Surgery, Graduate School of Medicine, Kobe University, Kobe City, Hyogo, Japan.

Aim: This study aims to validate Japanese diagnostic criteria for acute-on-chronic liver failure (ACLF) and confirm the feasibility of performing transplantation.

Methods: We included 60 patients with acute liver injury. Demographic and clinical features were retrospectively collected, and the primary outcome was compared among 4 types: acute liver failure (ALF) with hepatic coma (n = 23), ALF without hepatic coma (n = 12), acute liver injury (n = 20), and ACLF (n = 5). Read More

View Article and Full-Text PDF

Fasting gallbladder volume is increased in patients with Parkinson's disease.

Parkinsonism Relat Disord 2021 Apr 30;87:56-60. Epub 2021 Apr 30.

Department of Nuclear Medicine and PET, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, J220, 8200, Aarhus N, Denmark.

Introduction: Autonomic denervation in patients with Parkinson's disease (PD) and isolated REM-sleep behavior disorder (iRBD) could impede gallbladder function leading to increased fasting gallbladder volume (fGBV) and higher risk of gallstones. We aimed to determine fGBV in patients with PD, iRBD, and healthy controls (HCs).

Methods: We included 189 subjects; 100 patients with PD, 21 with iRBD, and 68 HCs. Read More

View Article and Full-Text PDF

Clinical manifestations, diagnosis, and treatment outcome of CNS aspergillosis: A systematic review of 235 cases.

Infect Dis Now 2021 May 5. Epub 2021 May 5.

Department of Radiology, Institute of Liver and Biliary Sciences, New Delhi, India.

Aspergillus is a ubiquitous ascomycete that can cause a variety of clinical presentations depending on immune status. Central nervous system aspergillosis is a fatal disease with non-specific clinical features. The aim of this systematic review was to evaluate the epidemiology, clinical features, diagnosis and therapeutic interventions in CNS aspergillosis patients. Read More

View Article and Full-Text PDF

Degradable magnesium implants inhibit gallbladder cancer.

Acta Biomater 2021 May 5. Epub 2021 May 5.

State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Suzhou Origin Medical Technology Co. Ltd., Suzhou, Jiangsu 215513, China. Electronic address:

Gallbladder cancer can be difficult to detect in its early stages and is prone to metastasize, causing bile duct obstruction, which is usually treated by stent implantation in clinic. However, the commonly used biliary stents are non-degradable, which not only prone to secondary blockage, but also need to be removed by secondary surgery. Biodegradable magnesium (Mg) is expected to one of the promising candidates for degradable biliary stents due to its excellent physicochemical property and biocompatibility. Read More

View Article and Full-Text PDF

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.

Cell Stem Cell 2021 May;28(5):816-832

Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address:

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. Read More

View Article and Full-Text PDF

Hepatocellular carcinoma with biliary and neuroendocrine differentiation: A case report.

World J Clin Oncol 2021 Apr;12(4):262-271

Department of Pathology and Laboratory Medicine, Medstar Georgetown University Hospital, Washington, DC 20007, United States.

Background: Liver tumors with dual differentiations [combined hepatocellular carcinoma (HCC) and cholangiocarcinoma] are common. However, liver tumors that exhibit hepatocellular, biliary, and neuroendocrine differentiation are exceedingly rare, with only three previous case reports in the literature.

Case Summary: A 65-year-old female with a previous history of hepatitis C and a distant history of low grade, well-differentiated rectal neuroendocrine tumor was found to have two liver lesions in segment 4 and segment 7 on imaging. Read More

View Article and Full-Text PDF

A rare case of gallstone ileus-the unanswered question.

Authors:
Chi Fai Tsang

J Surg Case Rep 2021 Apr 29;2021(4):rjab164. Epub 2021 Apr 29.

Department of General Surgery, Prince of Wales Hospital and Community Health Services, Sydney, New South Wales 2002, Australia.

Gallstone ileus is caused by an impaction of one or more gallstones within the gastrointestinal tract leading to mechanical intestinal obstruction. It is a rare complication of cholelithiasis and found in 2-3% of all cases associated with recurrent episodes of cholecystitis. This case study demonstrates an atypical presentation of gallstone ileus. Read More

View Article and Full-Text PDF

Elderly patients (≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients (< 80 years): Propensity score-matched analysis.

World J Hepatol 2021 Apr;13(4):456-471

Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore.

Background: Acute cholangitis (AC) is a disease spectrum with varying extent of severity. Age ≥ 75 years forms part of the criteria for moderate (Grade II) severity in both the Tokyo Guidelines (TG13 and TG18). Aging is associated with reduced physiological reserves, frailty, and sarcopenia. Read More

View Article and Full-Text PDF