65,903 results match your criteria Biliary Disease


How to treat Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

SS is a chronic, autoimmune disease of unknown aetiology for which there is no known curative treatment. Although dryness of the eyes and mouth are the classically described features, patients often experience drying of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia. There is an association with other autoimmune diseases, especially thyroid disease, coeliac disease and primary biliary cholangitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/key363DOI Listing
February 2019

[Establishment and one-year evaluation of an internal medicine consultation in a maternity].

Sante Publique 2018 September October;30(5):671-677

Objective: In the obstetric medicine movement and in response to requests for appointments in internal medicine by obstetricians and midwives, we created an internal medicine consultation within the maternity ward of our General Hospital, and provide feedback after 1 year.

Methods: This retrospective descriptive study took place at the Robert Ballanger Intercommunal Hospital Center in Aulnay-sous-Bois in Seine-Saint-Denis (France) between 3rd March 2016 and 9th March 2017, the first year of the internal medicine consultation, one afternoon every 15 days, in the maternity level 2b.

Results: Out of 121 appointments, 93 consultations were conducted for 63 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3917/spub.186.0671DOI Listing
February 2019

Critical Care Aspects of Gallstone Disease.

J Crit Care Med (Targu Mures) 2019 Jan 4;5(1):6-18. Epub 2019 Feb 4.

Department of Medicine, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, "Albert Einstein" College of Medicine, Bronx, NY 10461, USA.

Approximately twenty per cent of adults have gallstones making it one of the most prevalent gastrointestinal diseases in Western countries. About twenty per cent of gallstone patients requires medical, endoscopic, or surgical therapies such as cholecystectomy due to the onset of gallstone-related symptoms or gallstone-related complications. Thus, patients with symptomatic, uncomplicated or complicated gallstones, regardless of the type of stones, represent one of the largest patient categories admitted to European hospitals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/jccm-2019-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369569PMC
January 2019

Wilson's Disease: Clinical Practice Guidelines of the Indian National Association for Study of the Liver, the Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition, and the Movement Disorders Society of India.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):74-98. Epub 2018 Sep 3.

Department of Pediatrics and Pediatric Liver GI and Nutrition Center and Mowat Labs, King's College Hospital, London, UK.

Clinical practice guidelines for Wilson's disease (WD) have been published by the American Association for the Study of Liver Diseases and European Association for the Study of the Liver in 2008 and 2012, respectively. Their focus was on the hepatic aspects of the disease. Recently, a position paper on pediatric WD was published by the European Society of Pediatric Gastroenterology Hepatology and Nutrition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jceh.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363961PMC
September 2018

Results of Sofosbuvir Plus Ribavirin in Patients With Hepatitis C Related Decompensated Cirrhosis.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):4-12. Epub 2018 Mar 6.

Institute of Liver, Gastroenterology, & Panceatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.

Background: Sofosbuvir (SOF), a direct acting antiviral, has revolutionized the treatment of chronic Hepatitis C Virus (HCV) infection. However, data is scarce about efficacy of SOF plus Ribavarin (RBV) in Indian patients with decompensated cirrhosis. We evaluated the efficacy of SOF plus RBV in decompensated cirrhosis, and compared the outcome with compensated cirrhosis and non-cirrhotics. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09736883183004
Publisher Site
http://dx.doi.org/10.1016/j.jceh.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363947PMC
March 2018
2 Reads

The Pediatric Surgical Team: a Model for Increased Surgeon Index Case Exposure.

J Pediatr Surg 2019 Jan 21. Epub 2019 Jan 21.

Kapi'olani Medical Center for Children, 1319 Punahou St., Honolulu, HI, USA 96826.

Background/purpose: High surgical volume for both surgeons and hospital systems has been linked to improved outcomes for many surgical problems, yet case volumes per pediatric surgeon are diminishing nationally in complex pediatric surgery. We therefore sought to review our experience in a geographically isolated setting where a surgical team approach has been used to improve per-surgeon exposure to index pediatric surgical cases.

Methods: As a surgical group, we incorporated a surgical team approach to complex pediatric surgical cases in 2010. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2018.12.018DOI Listing
January 2019

Going Round in Circles with a Multisystemic Disease: A Unique Case of Parasitic Aortitis.

Eur J Case Rep Intern Med 2017 17;4(6):000601. Epub 2017 May 17.

Autoimmune Diseases Unit, Hospital Beatriz Ângelo, Loures, Portugal.

Aortitis results from aortic inflammation, frequent causes being infections and rheumatological disorders. The authors report the case of a 33-year-old black male with recent arterial hypertension, who presented with recurrent abdominal pain, jaundice, anorexia, weight loss and diarrhoea. Laboratory work-up was compatible with inflammatory anaemia and obstructive jaundice, while abdominal imaging revealed a dilated biliary tract, no visible gallstones, cephalic pancreatic globosity and aortic thickening. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2017_000601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346790PMC

Intralobar Pulmonary Sequestration and Increased Serum CA 19-9.

Eur J Case Rep Intern Med 2017 20;4(4):000583. Epub 2017 Feb 20.

Department of Internal Medicine, Gemelli Hospital, Catholic University, Rome, Italy.

Intralobar pulmonary sequestration is an uncommon congenital lung anomaly which consists of a mass of normal lung tissue not connected to the normal tracheobronchial tree and supplied by an anomalous systemic artery. Carbohydrate antigen 19-9 (CA 19-9) is widely accepted as a tumour marker for biliary, pancreatic and gastrointestinal cancer. However, CA 19-9 may also be increased in patients with benign disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2017_000583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346763PMC
February 2017

Comparison between a rotatable sphincterotome and a conventional sphincterotome for selective bile duct cannulation.

Endoscopy 2019 Feb 13. Epub 2019 Feb 13.

Division of Gastroenterology and Hepatology, Digestive Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.

Background:  Selective biliary cannulation (SBC) is the first challenge of endoscopic retrograde cholangiopancreatography (ERCP), especially for trainees, and a rotatable sphincterotome may be useful to guide the directional axis of the scope and SBC.

Methods:  We performed a prospective randomized single-center trial, enrolling 200 patients with a native papilla who required therapeutic biliary ERCP. Patients were randomly assigned to the rotatable sphincterotome group (n = 100) or the conventional sphincterotome group (n = 100). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0835-5900DOI Listing
February 2019
1 Read

Quantification of the impact of interventional radiology in the management of acute pancreatitis.

Ir J Med Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Tallaght University Hospital, Dublin 24, Ireland.

Objectives: Interventional radiology plays a central role in the management of complicated acute pancreatitis, contributing to image-guided drainages, treating haemorrhagic complications and maintaining the patency of the biliary tree. In addition, many of these patients require long-term venous access for antibiotics or parenteral feeding. The aim of this study was to evaluate the role and level of involvement of the interventional radiology in this sub-group of patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11845-019-01970-4DOI Listing
February 2019

A case of successfully resected metachronous gastric and gallbladder metastases from pancreatic body cancer.

Surg Case Rep 2019 Feb 13;5(1):21. Epub 2019 Feb 13.

Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.

Background: Pancreatic ductal adenocarcinoma (PDAC) readily metastasizes to the lymph nodes, liver, lung, and peritoneum; however, gastric and gallbladder metastases are rare. We report a case of metachronous gastric and gallbladder metastases from PDAC.

Case Presentation: The patient is a 71-year-old man who underwent distal pancreatectomy for PDAC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-019-0581-1DOI Listing
February 2019

Assessment of Anastomotic Biliary Complications in Adult Patients Undergoing High-Acuity Liver Transplant.

JAMA Surg 2019 Feb 13. Epub 2019 Feb 13.

Dumont-UCLA (University of California, Los Angeles) Transplant and Liver Cancer Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, UCLA.

Importance: Anastomotic biliary complications (ABCs) constitute the most common technical complications in liver transplant (LT). Given the ever-increasing acuity of LT, identification of factors contributing to ABCs is essential to minimize morbidity and optimize outcomes. A detailed analysis in a patient population undergoing high-acuity LT is lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamasurg.2018.5527DOI Listing
February 2019

[Diagnosis of Biliary Hamartomatosis in Kidney Transplant Recipient affected by ADPKD].

G Ital Nefrol 2019 Feb;36(1)

UO Nefrologia e Dialisi, Policlinico Germaneto, Catanzaro.

Biliary hamartomas (BH) are rare benign lesions of the liver characterized by a dilation of a variable number of small biliary ducts, usually surrounded by abundant fibrotic tissue. These malformations are due to an aberrant remodelling of the ductal plate, that is the embryonic structure generating the normal biliary tree. BH are usually asymptomatic, but in rare cases they can be associated with jaundice, heartburn and fever. Read More

View Article

Download full-text PDF

Source
February 2019

Ultrasound findings in paediatric cholestasis: how to image the patient and what to look for.

J Ultrasound 2019 Feb 12. Epub 2019 Feb 12.

Department of Radiology, "Federico II" University Hospital, Naples, Italy.

Paediatric biliary tract and gallbladder diseases include a variety of entities with a wide range of clinical presentations. Cholestasis represents an impaired secretion of bilirubin by hepatocytes, manifesting with high blood levels of conjugated bilirubin and jaundice. Various causes may be involved, which can be recognised analysing blood tests and hepatobiliary imaging, while sometimes liver biopsy or surgery may be necessary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40477-019-00362-9DOI Listing
February 2019

Kras-driven heterotopic tumor development from hepatobiliary organoids.

Carcinogenesis 2019 Feb 7. Epub 2019 Feb 7.

Central Animal Division, National Cancer Center Research Institute, Tokyo, Japan.

Cancers arising from the biliary tract are refractory to conventional therapies, requiring the development of novel therapeutics. However, only a limited number of genetically engineered mouse models have been created, partly due to time-consuming work required. Besides, liver-specific gene manipulation mostly resulted in concurrent development of hepatocellular carcinoma, another type of liver cancer, and gall bladder-restricted gene targeting is still not feasible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgz024DOI Listing
February 2019
1 Read

Correlation of early ROTEM parameters with conventional coagulation tests in patients with chronic liver disease undergoing liver transplant.

Indian J Anaesth 2019 Jan;63(1):21-25

Center for Liver and Biliary Sciences, Max Super Speciality Hospital, New Delhi, India.

Background And Aims: Viscoelastic tests such as rotational thromboelastometry (ROTEM) provide a quick and holistic assessment of coagulation status to guide transfusion during liver transplant (LT). Conventional coagulation tests (CCTs) measure single parameters in isolation, and also the results are delayed hampering management of patients during surgery. We evaluated the correlation of early ROTEM-derived parameters with CCTs and also assessed the ability of ROTEM-derived parameters to predict thrombocytopaenia and hypofibrinogenaemia during LT in patients with end-stage liver disease (ESLD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ija.IJA_334_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341893PMC
January 2019

A Phase I, Multicenter, Dose-Escalation Study of the Oral Selective FGFR inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations.

Clin Cancer Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Medicine, Memorial Sloan Kettering Cancer Center.

Purpose: To investigate tolerability, efficacy, and pharmacokinetics/-dynamics (PK/PD) of Debio 1347, a selective fibroblast growth factor receptor (FGFR) Inhibitor.

Experimental Design: This was a first-in-human, multicenter, open-label study in patients with advanced solid tumors harboring FGFR1-3 gene alterations. Eligible patients received oral Debio 1347 at escalating doses once daily until disease progression or intolerable toxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-18-1959DOI Listing
February 2019

Bone Health in Patients With Liver Diseases.

J Clin Densitom 2019 Jan 18. Epub 2019 Jan 18.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA. Electronic address:

Osteoporosis is the most common bone disease in chronic liver disease (CLD) resulting in frequent fractures and leading to significant morbidity in this population. In addition to patients with cirrhosis and chronic cholestasis, patients with CLD from other etiologies may be affected in the absence of cirrhosis. The mechanism of osteoporosis in CLD varies according to etiology, but in cirrhosis and cholestatic liver disease it is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocd.2019.01.004DOI Listing
January 2019
1 Read

Targeted Therapies in Cholangiocarcinoma: Emerging Evidence from Clinical Trials.

Medicina (Kaunas) 2019 Feb 8;55(2). Epub 2019 Feb 8.

Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy.

Cholangiocarcinoma (CCA) is a highly-aggressive malignancy arising from the biliary tree, characterized by a steady increase in incidence globally and a high mortality rate. Most CCAs are diagnosed in the advanced and metastatic phases of the disease, due to the paucity of signs and symptoms in the early stages. This fact, along with the poor results of the local and systemic therapies currently employed, is responsible for the poor outcome of CCA patients and strongly supports the need for novel therapeutic agents and strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina55020042DOI Listing
February 2019
1 Read

Chronic Pancreatitis Is Characterized by Distinct Complication Clusters That Associate With Etiological Risk Factors.

Am J Gastroenterol 2019 Feb 5. Epub 2019 Feb 5.

Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.

Objectives: Chronic pancreatitis (CP) is characterized by several disease-related complications and multiple etiological risk factors. Past studies of associations between complications and risk factors have mostly been limited to single complications or highly focused on single etiologies. Using an objective data-driven approach (cluster analysis), we characterized complication clusters and their associations with etiological risk factors in a large cohort of patients with CP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14309/ajg.0000000000000147DOI Listing
February 2019
1 Read
10.755 Impact Factor

International clinical guidelines for the management of phosphomannomutase 2-congenital disorders of glycosylation: Diagnosis, treatment and follow up.

J Inherit Metab Dis 2019 Jan;42(1):5-28

Department of Clinical Genomics, Mayo Clinic, Rochester, New York.

Phosphomannomutase 2 (PMM2-CDG) is the most common congenital disorder of N-glycosylation and is caused by a deficient PMM2 activity. The clinical presentation and the onset of PMM2-CDG vary among affected individuals ranging from a severe antenatal presentation with multisystem involvement to mild adulthood presentation limited to minor neurological involvement. Management of affected patients requires a multidisciplinary approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jimd.12024DOI Listing
January 2019
1 Read

Outcomes following percutaneous treatment of biliary stones.

HPB (Oxford) 2019 Feb 6. Epub 2019 Feb 6.

Radiology Unit, Department of Diagnostic and Preventive Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy.

Background: The percutaneous approach (PA) for management of biliary stones (BS) with or without an underlying biliary stenosis is an option for patients in whom an endoscopic approach (EA) is not possible. The aim of this study was to evaluate the efficacy of a PA in patients with BS unsuitable for an EA.

Methods: A retrospective review of a database was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hpb.2018.12.007DOI Listing
February 2019

Impact of a Multidisciplinary Team on Alcohol Recidivism and Survival After Liver Transplant for Alcoholic Disease.

Transplant Proc 2019 Jan - Feb;51(1):187-189. Epub 2018 Jun 30.

Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Background: Alcohol use disorders have a prevalence of 10% among the population of the United States and Europe and are one of the most frequent causes of liver cirrhosis in the Western world. Currently, alcohol-related liver cirrhosis represents one of the most frequent indications to liver transplant (LT), both as independent cause or associated with hepatitis C virus or hepatitis B virus infections. Starting from 2014, a multidisciplinary team involving surgeons, gastroenterologists, clinical toxicologists, psychiatrists, and psychologists was developed within the Modena Liver Transplant Center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2018.02.212DOI Listing
June 2018
1 Read

An improved and easy protocol for primary epithelial cell culture from atretic tissue in biliary atresia.

Tissue Cell 2019 Feb 4;56:83-89. Epub 2019 Jan 4.

Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education & Research, Chandigarh, India. Electronic address:

Biliary atresia (BA) is a lethal disease of infancy with obscure etiology. Insight into the pathogenesis of this disorder is limited by lack of availability of adequate epithelial tissue. Primary culture of human biliary epithelium may help to provide material for diagnostic and research purposes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tice.2019.01.001DOI Listing
February 2019

Atrial Fibrillation After Gastrointestinal Surgery: Incidence and Associated Risk Factors.

J Surg Res 2019 Feb 5;238:23-28. Epub 2019 Feb 5.

Clinical Research Fellow, Department of General Surgery, Sheffield Teaching Hospitals, Sheffield, UK. Electronic address:

Background: Atrial fibrillation (AF) is a common dysrhythmia that can occur after major physiological stress including surgery (postoperative AF). There are few data on postoperative AF after abdominal surgery. We set out to define the incidence of de novo postoperative AF after abdominal surgery and associated risk factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2019.01.017DOI Listing
February 2019
2 Reads

Primary biliary cholangitis patients exhibit MRI changes in structure and function of interoceptive brain regions.

PLoS One 2019 8;14(2):e0211906. Epub 2019 Feb 8.

Seaman Family MR Research Centre, University of Calgary, Calgary, Alberta, Canada.

Background: Many patients with primary biliary cholangitis (PBC) experience non-hepatic symptoms that are possibly linked to altered interoception, the sense of the body's internal state. We used magnetic resonance imaging (MRI) to determine if PBC patients exhibit structural and functional changes of the thalamus and insula, brain regions that process signals related to interoception.

Methods: Fifteen PBC patients with mild disease and 17 controls underwent 3 Tesla T1-weighted MRI, resting-state functional MRI, and quantitative susceptibility mapping (QSM), to measure thalamic and insular volume, neuronal activity and iron deposition, respectively. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211906PLOS
February 2019
2 Reads

In vivo H MRS of human gallbladder bile in understanding the pathophysiology of primary sclerosing cholangitis (PSC): Immune-mediated disease versus bile acid-induced injury.

NMR Biomed 2019 Feb 8:e4065. Epub 2019 Feb 8.

University of Manitoba, Winnipeg, Manitoba, Canada.

Primary sclerosing cholangitis (PSC) has been considered to be either an "autoimmune disease" or a "bile acid-induced injury." In vitro MRS studies on PSC patients have limitations due to the contamination of bile with contrast agent (commonly administered during endoscopic retrograde cholangiopancreatography) and/or the use of patient cohorts with other diseases as controls. The objective of this study was to quantify biliary metabolites using in vivo H MRS and gain insight into the pathogenesis of PSC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/nbm.4065DOI Listing
February 2019
1 Read

Hospital readmissions among older people with intellectual disability in comparison with the general population.

J Intellect Disabil Res 2019 Feb 8. Epub 2019 Feb 8.

Department of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden.

Background: Older people with intellectual disability have high multimorbidity and poor physical and mental health compared with the general population. Consequently, they have a greater need for health care. Hospital readmissions may be an indicator of the quality of health care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jir.12601DOI Listing
February 2019
2 Reads

ABCB4 / MDR3 in health and disease - at the crossroads of biochemistry and medicine.

Biol Chem 2018 Dec 1. Epub 2018 Dec 1.

Institute of Biochemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, D-40225 Düsseldorf, Germany.

Several ABC transporters of the human liver are responsible for the secretion of bile salts, lipids and cholesterol. Their interplay protects the biliary tree from the harsh detergent activity of bile salts. Among these transporters, ABCB4 is essential for the translocation of phosphatidylcholine lipids from the inner to the outer leaflet of the canalicular membrane of hepatocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/hsz-2018-0441DOI Listing
December 2018
1 Read

How to deal with severe acute pancreatitis in the critically ill.

Curr Opin Crit Care 2019 Feb 5. Epub 2019 Feb 5.

Purpose Of Review: To review recent literature on the management of patients with severe acute pancreatitis (SAP) admitted to an ICU.

Recent Findings: SAP is a devastating disease associated with a high morbidity and mortality. Recent evidence advocates adequate risk assessment and severity prediction (including intra-abdominal pressure monitoring), tailored fluid administration favoring balanced crystalloids, withholding prophylactic antibiotic therapy, and early detection and treatment of extra-pancreatic and fungal infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCC.0000000000000596DOI Listing
February 2019
2 Reads

Immunotherapeutic advances in gastrointestinal malignancies.

NPJ Precis Oncol 2019 5;3. Epub 2019 Feb 5.

1Montefiore Medical Center, 1695 Eastchester Road Bronx, New York, 10461 USA.

Cancer is an important global issue with increasing incidence and mortality, placing a substantial burden on the healthcare system. Colorectal cancer is the third most common cancer diagnosed among men and women in US. It is estimated that in 2018 there will be 319,160 new diagnosis and 160,820 deaths related to cancer of the digestive system including both genders in the United States alone. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41698-018-0076-8
Publisher Site
http://dx.doi.org/10.1038/s41698-018-0076-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363766PMC
February 2019
1 Read

Assessment of clinical outcome of cholecystectomy according to age in preparation for the "Silver Tsunami".

Am J Surg 2019 Jan 25. Epub 2019 Jan 25.

Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.

Background: Recent rapid increases in the aging population have created an impending "Silver Tsunami" in advanced countries. The overall prevalence of gallstone disease and its related complications will soon increase, and there will be a larger demand for gallbladder surgery.

Methods: We examined the outcomes of cholecystectomy according to age among patients with cholelithiasis to determine how a patient's age influences the outcome of cholecystectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjsurg.2019.01.021DOI Listing
January 2019
1 Read

Primary Sclerosing Cholangitis: A Concise Review of Diagnosis and Management.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Section of Gastroenterology, Evans Department of Medicine, Boston University School of Medicine, Suite 7717, 85 E Concord St, Boston, MA, 02118, USA.

Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterized by progressive idiopathic stricturing of the biliary system, typically leading to cirrhosis, end-stage liver disease, and colonic or hepatobiliary malignancy. Its presentation is often that of asymptomatic alkaline phosphatase elevation. When symptoms are present, they typically include fatigue, pruritus, or jaundice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-019-05484-yDOI Listing
February 2019
1 Read

[The effectiveness of the application of medicinal mineral water from the 'Omonkhona' source in the patients presenting with the diseases of the hepatobiliary system].

Authors:
Z R Zunnunov

Vopr Kurortol Fizioter Lech Fiz Kult 2019 ;96(1):22-29

Tashkent Institute of Enhancing the Qualifications of Doctors, Tashkent, Uzbekistan.

Background: Investigations into the medicinal properties of 'Omonkhona' mineral water used for the treatment of hepatobiliary pathology make up the entirely new field of balneological research in Uzbekistan.

Aim: The objective of the present study was to identify the hepatoprotective and choleretic components of the 'Omonkhona' mineral water and elucidate their action in the patients presenting with the diseases of the hepatobiliary system.

Material And Methods: A total of 77 patients suffering from the diseases of the hepatobiliary system were available for the examination including 38 patients with chronic hepatitis (CH), 17 with chronic cholecystitis (CC), and 22 patients with liver cirrhosis (Cr). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/kurort20199601122DOI Listing
January 2019
1 Read

Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 knockout mice via let-7 microRNA.

Hepatology 2019 Feb 5. Epub 2019 Feb 5.

Research, Central Texas Veterans Health Care System, Temple, TX, USA.

Cholangiopathies are diseases that affect cholangiocytes, the cells lining the biliary tract. Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly influence the surrounding liver tissue by secretion of signaling molecules. One way in which cells can interact is through secretion of extracellular vesicles (EVs), which are small membrane-bound vesicles, containing proteins, miRNAs and cytokines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.30542DOI Listing
February 2019
1 Read

PROMININ-1 promotes biliary fibrosis associated with biliary atresia.

Hepatology 2019 Feb 5. Epub 2019 Feb 5.

Children's Hospital Los Angeles, Surgery, Los Angeles, CA, USA.

Background: In patients with biliary atresia (BA), the extent of intrahepatic biliary fibrosis negatively correlates with successful surgical bypass of the congenital cholangiopathy as well as subsequent transplant-free survival. We recently linked the expansion of a population of Prominin-1 (Prom1)-expressing hepatic progenitor cells to biliary fibrogenesis. Herein, we hypothesized that Prom1-expressing progenitor cells play a role in BA-associated fibrosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.30550DOI Listing
February 2019
1 Read

TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function.

Gut 2019 Feb 5. Epub 2019 Feb 5.

U1174, INSERM, Orsay, France.

Objective: We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA overload through the regulation of biliary epithelium permeability.

Design: Experiments were performed under basal and TGR5 agonist treatment. In vitro transepithelial electric resistance (TER) and FITC-dextran diffusion were measured in different cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2018-316975DOI Listing
February 2019
1 Read

Mechanisms of Action of Probiotics.

Adv Nutr 2019 Jan;10(suppl_1):S49-S66

Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Armilla, Granada, Spain.

Probiotics are living microorganisms that confer health benefits to the host when administered in adequate amounts; however, dead bacteria and their components can also exhibit probiotic properties. Bifidobacterium and strains of lactic acid bacteria are the most widely used bacteria that exhibit probiotic properties and are included in many functional foods and dietary supplements. Probiotics have been shown to prevent and ameliorate the course of digestive disorders such as acute, nosocomial, and antibiotic-associated diarrhea; allergic disorders such as atopic dermatitis (eczema) and allergic rhinitis in infants; and Clostridium difficile-associated diarrhea and some inflammatory bowel disorders in adults. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/advances/article/10/suppl_1/S49/530
Publisher Site
http://dx.doi.org/10.1093/advances/nmy063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363529PMC
January 2019
1 Read

TCRβ Repertoire of Memory T cell Reveals Potential Role for E.coli in the Pathogenesis of Primary Biliary Cholangitis.

Liver Int 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China.

Background: Primary biliary cholangitis (PBC) is an organ-specific, T cell mediated autoimmune disease which is characterized by the breakdown of self-tolerance to the highly conserved pyruvate dehydrogenase complex, especially the pyruvate dehydrogenase E2 complex (PDC-E2). However, the molecular mechanism of breakdown of self-tolerance is still unclear.

Methods: A combination of multiplex-PCR and immune repertoire sequencing (IR-seq) was used for a standardized analysis of memory T cell receptor (TCR) β-chain repertoire of PBC patient and healthy volunteers. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.14066
Publisher Site
http://dx.doi.org/10.1111/liv.14066DOI Listing
February 2019
2 Reads

Tandem Orthotopic Living Donor Liver Transplantation Followed by Same Donor Haploidentical Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency: Tandem Liver and Bone Marrow Transplant in DOCK8 Deficiency.

Transplantation 2019 Jan 30. Epub 2019 Jan 30.

Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: An 11-year old girl with DOCK8 deficiency was proposed for potentially curative hematopoietic stem cell transplantation (HSCT), the donor being her haploidentical mother. However, end-stage liver disease, caused by chronic Cryptosporidium infection required liver transplantation before HSCT.

Methods: Consequently, a staged approach of a sequential liver transplant followed by a HSCT was planned, with her mother as the donor for both liver and HSCT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000002649DOI Listing
January 2019
2 Reads

Rare case report of acalculous cholecystitis: Gallbladder torsion resulting in rupture.

SAGE Open Med Case Rep 2019 11;7:2050313X18823385. Epub 2019 Jan 11.

Department of Surgery, Wollongong Hospital, Wollongong, NSW, Australia.

Acalculous cholecystitis caused by gallbladder torsion is a rare condition. Only 500 cases have been reported since the first diagnosed case in 1898. We present the case of a 89-year-old woman with sudden onset of severe epigastric pain, radiating across her right costal margin, associated with nausea. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/2050313X18823385
Publisher Site
http://dx.doi.org/10.1177/2050313X18823385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349984PMC
January 2019
2 Reads

Technical Feasibility and Clinical Effectiveness of Transjugular Intrahepatic Portosystemic Shunt Creation in Pediatric and Adolescent Patients.

J Vasc Interv Radiol 2019 Feb;30(2):178-186.e5

Division of Interventional Radiology, Department of Radiology, University of Washington, Seattle, Washington; Seattle Children's Hospital, Seattle, Washington.

Purpose: To examine the technical feasibility and clinical efficacy of transjugular intrahepatic portosystemic shunt (TIPS) creation in children and adolescents.

Materials And Methods: Retrospective review was performed of 59 patients (mean age 12.6 y [range, 1. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10510443183158
Publisher Site
http://dx.doi.org/10.1016/j.jvir.2018.10.003DOI Listing
February 2019
2 Reads
2.149 Impact Factor

How Would You Treat This Patient With Gallstone Pancreatitis?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

Ann Intern Med 2019 Feb;170(3):175-181

Beth Israel Deaconess Medical Center, Boston, Massachusetts (A.T., S.D.F., T.K., H.L.).

Acute pancreatitis, a common cause of hospitalization in the United States, is often the result of biliary tract disease. In 2016, the American Gastroenterological Association released a guideline that addresses the practical considerations in managing acute pancreatitis within the first 72 hours after the patient presents. The guideline specifically recommends goal-directed hydration therapy, early enteral feeding, judicious use of endoscopic retrograde cholangiopancreatography (ERCP), and gallbladder surgery during the index admission for patients with mild pancreatitis. Read More

View Article

Download full-text PDF

Source
http://annals.org/article.aspx?doi=10.7326/M18-3536
Publisher Site
http://dx.doi.org/10.7326/M18-3536DOI Listing
February 2019
3 Reads

Biliary hyperkinesia, a new diagnosis or misunderstood pathophysiology of dyskinesia: A case report.

Int J Surg Case Rep 2019 Jan 19;55:80-83. Epub 2019 Jan 19.

Beaumont Health Farmington Hills, General Surgery Department, 28050 Grand River Avenue, Farmington Hills, MI 48336, USA. Electronic address:

Introduction: Biliary colic, characterized by intermittent right upper quadrant abdominal pain is a common complaint in the United States population. Patients whose pain is undiagnosed by ultrasound generally undergo hepatobiliary iminodiacetic acid scan with cholecystokinin stimulation (HIDA-CCK) to assess function of the gallbladder and biliary tree. Traditionally, two outcomes are possible based on a measured ejection fraction of the gallbladder: either dyskinesia or normal function is diagnosed. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22102612193002
Publisher Site
http://dx.doi.org/10.1016/j.ijscr.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360460PMC
January 2019
10 Reads

Second Line Chemotherapy in Biliary Tract Cancer: Outcome and Prognostic Factors.

Liver Int 2019 Feb 4. Epub 2019 Feb 4.

Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany.

Background & Aims: The prognosis of biliary tract cancer (BTC) is poor. Standard treatment for advanced BTC is a chemotherapy (CT) with gemcitabine and cisplatin. Phase-III evidence for a second line (2L) CT is lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/liv.14063DOI Listing
February 2019
1 Read

Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy.

Pancreatology 2019 Jan 25. Epub 2019 Jan 25.

Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Norway. Electronic address:

Background: The clinical relevance of the classification of ampullary adenocarcinoma (AC) into pancreatobiliary (PB) or intestinal (Int) subtypes has not been resolved.

Methods: Clinicopathological factors, survival, and localization and treatment of recurrence were investigated for patients with AC and duodenal adenocarcinoma (DC) treated by pancreatoduodenectomy from 2000 to 2015.

Results: A total of 109 AC (45 PB, 64 Int) and 71 DC (all Int) were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pan.2019.01.019DOI Listing
January 2019

Surgical aspects of liver transplantation and domino liver transplantation in maple syrup urine disease: analysis of 15 donor / recipient pairs.

Liver Transpl 2019 Feb 3. Epub 2019 Feb 3.

Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Liver transplantation (LT) has been shown to be a feasible treatment in patients with severe forms of maple syrup urine disease (MSUD). Due to a sufficient extrahepatic enzyme activity in non-MSUD individuals, the organ of MSUD patients can be used as domino graft. We performed a retrospective data collection of all LTs for MSUD carried out at the University Medical Center Hamburg-Eppendorf (2016-2018). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/lt.25423
Publisher Site
http://dx.doi.org/10.1002/lt.25423DOI Listing
February 2019
3 Reads
4.241 Impact Factor