66,373 results match your criteria Biliary Disease


Hospitalization Burden of Biliary Strictures and Cholangitis After Pancreaticoduodenectomy.

J Surg Res 2019 Apr 21;241:95-102. Epub 2019 Apr 21.

Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: Postsurgical biliary disease in Roux-en-y and cholecystectomies has been investigated, but less literature exists regarding biliary complications after Whipple procedure (pancreaticoduodenectomy [PD]). Moreover, the hospital burden incurred after this complication has not been previously examined. The aim of this study is to assess the trends in hospitalization for biliary strictures and cholangitis after PD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193017
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http://dx.doi.org/10.1016/j.jss.2019.03.057DOI Listing
April 2019
4 Reads

Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.

Methods Mol Biol 2019 ;1981:363-372

Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.

Cholangiopathies, including primary sclerosing cholangitis, are a group of heterogeneous diseases characterized by inflammation and fibrosis of the intrahepatic and extrahepatic bile duct epithelium. Studies, especially of primary sclerosing cholangitis, have been hampered by the difficulty in accessing the cholangiocyte, instability of in vitro culture systems, and reliance on (limited) samples from end-stage disease. Here we describe a novel method of culturing biliary cells from bile of primary sclerosing cholangitis patients undergoing endoscopic retrograde cholangiopancreatography for clinical indications. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_24DOI Listing
January 2019

A Rotavirus-Induced Mouse Model to Study Biliary Atresia and Neonatal Cholestasis.

Methods Mol Biol 2019 ;1981:259-271

Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Centre, Cincinnati, OH, USA.

Biliary atresia is a devastating neonatal cholangiopathy that affects both extra- and intrahepatic bile ducts progressing to fibrosis and end-stage liver disease by 2 years of age. Despite re-establishment of biliary drainage following a Kasai portoenterostomy (surgical procedure), many infants develop fibrosis requiring liver transplant. In the murine model of biliary atresia, rhesus rotavirus infection of newborn pups results in a cholangiopathy paralleling human biliary atresia and is used to study mechanistic aspects of the disease. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_17DOI Listing
January 2019

3,5-Diethoxycarbonyl-1,4-Dihydrocollidine Diet: A Rodent Model in Cholestasis Research.

Methods Mol Biol 2019 ;1981:249-257

Liver Unit, Hospital Clínic de Barcelona, Institut D'Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain.

Liver cholestasis is characterized by impairment in bile flow. Among cholestatic diseases, primary biliary cholangitis and primary sclerosing cholangitis represent relevant causes of chronic liver disease, associated to significant morbidity and mortality. To better understand and to address therapeutic strategies to cholangiopathies is essential to develop an in vivo model which recapitulates the pathological features of the disease. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_16DOI Listing
January 2019
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Common Bile Duct Ligation as Model for Secondary Biliary Cirrhosis.

Methods Mol Biol 2019 ;1981:237-247

Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.

Cholestatic liver disease covers a range of biliary disorders marked by an impaired bile duct flow. Various conditions can result in bile obstruction including choledocholithiasis, surgical trauma, and autoimmune disorders. Cholestatic liver disease can be mild but generally progresses to more severe conditions with increased hepatobiliary injury, cholangitis, and ultimately liver fibrosis and cirrhosis. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_15DOI Listing
January 2019

Mouse Models for Diseases in the Cholangiocyte Lineage.

Methods Mol Biol 2019 ;1981:203-236

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.

Cholangiopathies are an important group of liver diseases affecting the biliary system, and the purpose of this review is to describe how diseases in the biliary system can be studied in mouse models. A particular focus is placed on mouse models for Alagille syndrome, a cholangiopathy with a strong genetic link to dysfunctional Notch signaling. Recently, a number of different genetic mouse models based on various manipulations of the Notch signaling pathway have been generated to study Alagille syndrome, and we discuss the resulting phenotypes, and possible causes for the phenotypic heterogeneity among the various models. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_14DOI Listing
January 2019

Proteomics in Primary Biliary Cholangitis.

Methods Mol Biol 2019 ;1981:163-173

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.

Primary biliary cholangitis is a chronic cholestatic liver disease characterized by the presence of serum antimitochondrial antibodies and immune-mediated destruction of the small and medium-sized intrahepatic bile ducts. However, the pathophysiology of primary biliary cholangitis has not yet been completely elucidated. In recent years, proteomics has been comprehensively applied in many research fields, including the pathogenesis, prognosis, and diagnosis of disease. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_11DOI Listing
January 2019

Non-malignant Helicobacter pylori-Associated Diseases.

Adv Exp Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.

Helicobacter pylori infection of the human stomach is associated with chronic gastritis, peptic ulcer disease or gastric carcinoma, and thus a high burden for the public health systems worldwide. Fortunately, only a small subfraction of up to 15-20% of infected individuals will develop serious complications. Unfortunately, it is not always known upfront, who will be affected by serious diesease outcome. Read More

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http://dx.doi.org/10.1007/5584_2019_362DOI Listing

CholedochoClip: A Case of Obstructive Jaundice 14 Years after Cholecystectomy.

Case Rep Gastrointest Med 2019 19;2019:8038469. Epub 2019 Mar 19.

Department of Internal Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA.

Gallstone disease is a common gastrointestinal pathology that may result in surgical intervention. While cholecystectomy has relatively minimal risks, surgical clip migration is a rare complication that can cause severe morbidity and mortality. This report describes a rare phenomenon of a biliary stone forming onto a migrated surgical clip 14 years after cholecystectomy causing an obstructive jaundice. Read More

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http://dx.doi.org/10.1155/2019/8038469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444230PMC

Successful percutaneous treatment of biliary stenosis after living donor liver transplantation in a child.

Radiol Case Rep 2019 Jul 15;14(7):800-804. Epub 2019 Apr 15.

Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, PO Box 30.001, Groningen, 9700 RB, The Netherlands.

We report the case of a 16-year-old boy with primary clerosing holangitis associated with inflammatory bowel disease who was initially treated and controlled pharmacologically. He underwent living donor liver transplantation (LDLT) after he developed progressive biliary tract abnormalities and portal hypertension accompanied by recurrent bile duct infections. Two months following LDLT, the hepaticojejunostomy anastomosis became occluded and it was treated surgically. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468169PMC

Biliary tract cancers: current knowledge, clinical candidates and future challenges.

Cancer Manag Res 2019 29;11:2623-2642. Epub 2019 Mar 29.

Faculty of Biomedicine and Health Sciences, Division of Cancer Sciences, University of Manchester, Manchester M13 9NT, UK,

Biliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic sequencing, new data have emerged regarding the molecular makeup of this disease. To add to the complexity, various subtypes also harbor a varied genetic composition. Read More

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http://dx.doi.org/10.2147/CMAR.S157092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446989PMC

Leukocyte mitochondrial DNA copy number as a potential biomarker indicating poor outcome in biliary atresia and its association with oxidative DNA damage and telomere length.

Mitochondrion 2019 Apr 20. Epub 2019 Apr 20.

Department of Biochemistry, Osteoarthritis and Musculoskeleton Research Unit, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok, Thailand. Electronic address:

Biliary atresia (BA) is a chronic obstructive liver disease, leading to advanced liver failure. Mitochondria dysfunction-mediated aberrant telomere length has been implicated in various pathological processes including cholestasis. Herein, we aimed to investigate associations between mitochondrial DNA (mtDNA) copy number, oxidative DNA damage, telomere length, and disease severity in BA patients. Read More

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http://dx.doi.org/10.1016/j.mito.2019.04.006DOI Listing

The gut-liver axis in PSC: Are pathobionts the missing link?

Hepatology 2019 Apr 23. Epub 2019 Apr 23.

Division of Gastroenterology and Hepatology and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.

Primary sclerosing cholangitis (PSC) is characterized by progressive fibrosis around intra- and extrahepatic bile ducts that can progress to cirrhosis and liver failure. There are no regulatory drugs approved for PSC and liver transplantation is the only effective therapy(1). While the concentric accumulation of periductular fibrosis suggests the biliary epithelial cell (cholangiocyte) plays an integral role in disease initiation and/or progression, multiple factors from the gut like microbes and their molecular products, endogenous metabolites like bile acids, and primed immune cells have been hypothesized to play a significant role in the hepatobiliary injury and adverse clinical sequelae in PSC. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30673
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http://dx.doi.org/10.1002/hep.30673DOI Listing
April 2019
1 Read

The Evaluation of the Eighth Edition of the AJCC/UICC Staging System for Intrahepatic Cholangiocarcinoma: a Proposal of a Modified New Staging System.

J Gastrointest Surg 2019 Apr 22. Epub 2019 Apr 22.

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, 1007, Shimo-Nagakubo, Sunto-Nagaizumi, Shizuoka, 4118777, Japan.

Background: The objective was to clarify the prognostic impact of the 8th edition of American Joint Committee on Cancer (AJCC)/International Union Against Cancer (UICC) of intrahepatic cholangiocarcinoma (ICC).

Methods: A total of 103 ICC patients who underwent hepatectomy between 2002 and 2016 were enrolled. The survival impact of AJCC/UICC 8th edition was examined. Read More

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http://dx.doi.org/10.1007/s11605-019-04185-1DOI Listing

Assessment of the difficulties in laparoscopic cholecystectomy among patients at Baghdad province.

Ann Med Surg (Lond) 2019 May 27;41:16-19. Epub 2019 Mar 27.

Department of Surgery, University of Baghdad/College of Medicine, Baghdad, Iraq.

Background: Laparoscopic surgery for gallbladder cholecystectomy has become the typical procedure for symptomatic gallbladder stone diseases treatment as a type of minimal invasiveness surgery associated with less pain and early recovery as there is minimal trauma of access without shrinking the exposure of operative field. The current study aimed to assess factors associated with difficult LC.

Methodology: A cross sectional study was conducted at medical city complex (Baghdad Teaching Hospital) from October 2015 to October 2016, in which all patients that were admitted for LC were examined preoperatively, underwent LC and followed postoperatively to study factors associated with difficult LC. Read More

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http://dx.doi.org/10.1016/j.amsu.2019.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460222PMC

Demystifying the Use of Self Expandable Interwoven Nitinol Stents in Femoropopliteal Peripheral Arterial Disease.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

The Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK,. Electronic address:

Femoropopliteal atherosclerosis affects a significant percentage of the world population leading to intermittent claudication and critical limb ischemia. The femoropopliteal segment has a unique set of biomechanical challenges that must be considered and overcome for treatment. The use of stents is a reality and a necessity in peripheral interventions. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.01.014DOI Listing

[An unusual cause of jaundice].

Pan Afr Med J 2018 2;31:72. Epub 2018 Oct 2.

Service d'Hépato-Gastroentérologie de l'Hôpital Aritide Le Dantec, Dakar, Sénégal.

Hepatic impairment is common during hyperthyroidism. It is most often asymptomatic. Hyperthyroidism revealed by jaundice has been rarely described in the literature. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.72.16967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457717PMC
October 2018

Outside the liver box: The gut microbiota as pivotal modulator of liver diseases.

Biochim Biophys Acta Mol Basis Dis 2019 May 6;1865(5):912-919. Epub 2018 Jul 6.

Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, S-413 45 Gothenburg, Sweden. Electronic address:

The gut microbiota affects host physiology and has evolved as an important contributor to health and disease. Gut and liver are closely connected and communicate via the portal vein and the biliary system so the liver is constantly exposed to gut-derived bacterial products and metabolites. The intestinal barrier is important for maintaining physical and functional separation between microbes in the gut and the interior of the host and disruption of the barrier function can lead to bacterial translocation and increased leakage of bacterial metabolites. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.07.004DOI Listing

Drugs and hepatic transporters: A review.

Pharmacol Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091 Zürich, Switzerland.

The liver is the primary organ for the metabolic degradation of xenobiotics. Transmembrane transport proteins from the ABC and the SLC families mediate the uptake of endogenous compounds and xenobiotics into the hepatocyte as well as their elimination from the cells. Multiple processes are involved. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618193003
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http://dx.doi.org/10.1016/j.phrs.2019.04.018DOI Listing
April 2019
4 Reads

Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis.

Gut 2019 Apr 19. Epub 2019 Apr 19.

Centre de Recherche Saint-Antoine (CRSA), Sorbonne Université, INSERM, Paris, France.

Objective: Patients with primary sclerosing cholangitis (PSC) were previously shown to display a bacterial gut dysbiosis but fungal microbiota has never been examined in these patients. The aim of this study was to assess the fungal gut microbiota in patients with PSC.

Design: We analysed the faecal microbiota of patients with PSC and concomitant IBD (n=27), patients with PSC and no IBD (n=22), patients with IBD and no PSC (n=33) and healthy subjects (n=30). Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317791DOI Listing

Optimal dilation time for combined small endoscopic sphincterotomy and balloon dilation for common bile duct stones: a multicentre, single-blinded, randomised controlled trial.

Lancet Gastroenterol Hepatol 2019 Apr 16. Epub 2019 Apr 16.

Fifth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China; Hepatopancreatobiliary Surgery Institute of Gansu Province, Clinical Medical College Cancer Center of Lanzhou University, Lanzhou, China; Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province, Lanzhou, China. Electronic address:

Background: Endoscopic sphincterotomy is the established treatment for common bile duct stones. Balloon dilation offers an alternative. Prolonged dilation (300 s) with a 10 mm diameter balloon decreases the occurrence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Read More

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http://dx.doi.org/10.1016/S2468-1253(19)30075-5DOI Listing

Early experience of combination therapy of transarterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma measuring 3-7 cm.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):47-52

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Background Of The Article: Hepatocellular carcinoma (HCC) is one of the most common human malignancies worldwide. Radiofrequency ablation (RFA) is considered curative option in selected patients; efficacy is severely limited by lesion size and lesions bordering a large vessel. On the other hand, transarterial chemoembolization (TACE) is not limited by lesion size and arterial occlusion of the tumor feeding vessels leads to increase the volume of the ablative zone. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_352_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467046PMC

Safety and outcomes of pre-operative portal vein embolization using N-butyl cyanoacrylate (Glue) in hepatobiliary malignancies: A single center retrospective analysis.

Indian J Radiol Imaging 2019 Jan-Mar;29(1):40-46

Department of Liver Transplantation and Hepato Pancreatico Biliary Surgery, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, India.

Aims And Objectives: To evaluate the outcome of preoperative portal vein embolization (PVE) using N-butyl cyanoacrylate (NBCA) for change in future liver remnant (FLR) volume, biochemical changes, and procedure-related complications. The factors affecting FLR hypertrophy and the rate of resection was also evaluated for this cohort.

Materials And Methods: From 2012 to 2017, PVE utilizing NBCA mixed with lipiodol (1:4) was performed using percutaneous approach in 28 patients with hepatobiliary malignancies with low FLR. Read More

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http://www.ijri.org/text.asp?2019/29/1/40/255238
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http://dx.doi.org/10.4103/ijri.IJRI_454_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467029PMC
April 2019
2 Reads

Hemorrhagic Cholecystitis: A Case of Expedited Diagnosis by Point-of-Care Ultrasound in the Emergency Department.

J Emerg Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Emergency Medicine, Huntington Hospital, Huntington, New York.

Background: Hemorrhagic cholecystitis is a rare complication of acute cholecystitis and is a potentially fatal diagnosis. It may be difficult to detect because the symptoms are similar to more common diagnoses. Point-of-care ultrasound is a useful imaging technique in the emergency setting and is readily available to allow for immediate interpretation and application of the results to guide medical decision making. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.03.010DOI Listing
April 2019
1 Read

Gemcitabine, Cisplatin, and nab-Paclitaxel for the Treatment of Advanced Biliary Tract Cancers: A Phase 2 Clinical Trial.

JAMA Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Medical Oncology, Mayo Clinic, Phoenix, Arizona.

Importance: Administration of gemcitabine-cisplatin, the current standard therapy for advanced biliary tract cancers, results in median progression-free survival and overall survival of 8.0 and 11.7 months, respectively. Read More

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http://dx.doi.org/10.1001/jamaoncol.2019.0270DOI Listing
April 2019
1 Read

Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Klinikum rechts der Isar, The Technical University of Munich, Munich, Germany.

Hepatocellular carcinoma (HCC) is a fatal disease with increasing morbidity and poor prognosis due to surgical recurrence and metastasis. Moreover, the molecular mechanism of HCC progression remains unclear. Although the role of p120-catenin (p120ctn) in liver cancer is well studied, the effects of secreted p120ctn transported by exosomes are less understood. Read More

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http://dx.doi.org/10.1002/mc.23022DOI Listing

Man with epigastric pain and persistently elevated serum lipase.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Queensland Diabetes and Endocrine Centre, Mater Misericordiae Brisbane Ltd, South Brisbane, Queensland, Australia.

Serum lipase and amylase are commonly requested in individuals presenting with abdominal pain for investigation of acute pancreatitis. Pancreatic hyperenzymaemia is not specific for acute pancreatitis, occurring in many other pancreatic and non-pancreatic conditions. Where persistent elevation of serum lipase and amylase occurs in the absence of a diagnosed cause or evidence of laboratory assay interference, ongoing radiological assessment for pancreatic disease is required for 24 months before a diagnosis of benign pancreatic hyperenzymaemia can be made. Read More

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http://dx.doi.org/10.1136/bcr-2019-229208DOI Listing
April 2019
1 Read

Biliary dilatation in a 67-year-old woman: seeing is believing.

Gut 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, China.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-318200
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http://dx.doi.org/10.1136/gutjnl-2018-318200DOI Listing
April 2019
2 Reads

IgG4 Sclerosing Cholangitis - an Inflammation Imitating Tumour of the Pancreas and Biliary Tract.

Klin Onkol 2019 ;32(2):143-151

Background: Immunoglobulin (Ig) G4 associated sclerosing cholangitis is a rare inflammatory disease of the biliary tract. Although it is a very progressive condition, it responds to steroid therapy. IgG4 associated sclerosing cholangitis can mimic pancreatic carcinoma, cholangiocarcinoma, and primary sclerosing cholangitis; therefore, it is very important to obtain a differential diagnosis. Read More

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https://www.linkos.cz/english-summary/klinicka-onkologie-jou
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http://dx.doi.org/10.14735/amko2019143DOI Listing
January 2019
2 Reads

The gut and the Inflammatory Bowel Diseases inside-out: the extra-intestinal manifestations.

Minerva Gastroenterol Dietol 2019 Apr 16. Epub 2019 Apr 16.

The Medical Center Practice Office, Turin, Italy.

An increasing deal of attention is being conveyed on the extra-intestinal manifestations of inflammatory bowel diseases (IBD). We compiled the present review in an attempt to upgrade the accuracy of the classification of such polymorphic entities. We focused on three patterns. Read More

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http://dx.doi.org/10.23736/S1121-421X.19.02577-7DOI Listing
April 2019
1 Read

Long noncoding RNA HOXA-AS2 regulates the expression of SCN3A by sponging miR-106a in breast cancer.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Shanghai Research Center of Biliary Tract Disease, Shanghai, China.

Breast cancer is the most commonly diagnosed cancer that affects women worldwide. This study aimed to investigate the competing endogenous RNAs (ceRNAs) mechanism in breast cancer. Microarray data were downloaded from the University of California Santa Cruz (UCSC) Xena database. Read More

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http://dx.doi.org/10.1002/jcb.28706DOI Listing

Notch Inhibition Promotes Differentiation of Liver Progenitor Cells into Hepatocytes via Repression in Zebrafish.

Stem Cells Int 2019 12;2019:8451282. Epub 2019 Mar 12.

Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, USA.

Liver regeneration after most forms of injury is mediated through the proliferation of hepatocytes. However, when hepatocyte proliferation is impaired, such as during chronic liver disease, liver progenitor cells (LPCs) arising from the biliary epithelial cell (BEC) compartment can give rise to hepatocytes to mediate hepatic repair. Promotion of LPC-to-hepatocyte differentiation in patients with chronic liver disease could serve as a potentially new therapeutic option, but first requires the identification of the molecular mechanisms driving this process. Read More

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http://dx.doi.org/10.1155/2019/8451282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434270PMC

Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets.

Expert Opin Ther Targets 2019 Apr 16:1-12. Epub 2019 Apr 16.

a Indiana Center for Liver Research, Division of Gastroenterology & Hepatology, Department of Medicine , Indiana University School of Medicine , Indianapolis , IN , USA.

Introduction: The common predominant clinical features of cholangiopathies such as primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and biliary atresia (BA) are biliary damage/senescence and liver fibrosis. Curative therapies are lacking, and liver transplantation is the only option. An understanding of the mechanisms and pathogenesis is needed to develop novel therapies. Read More

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http://dx.doi.org/10.1080/14728222.2019.1608950DOI Listing
April 2019
5 Reads

[Protective effects and action mechanism of extract from Tibetan medicine Yajima(Chrysosplenium nudicaule) on mice with intrahepatic cholestasis induced by ANIT].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(5):1058-1063

Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China.

Chrysosplenium nudicaule,Tibetan name " Yajima",is recorded as an effective medicine for the treatment of liver and gallbladder diseases by Tibetan Pharmacopoeia published in the past dynasties,but its traditional efficacy has not yet been investigated by means of modern pharmacological research methods. In this paper,the protective effect of extract of C. nudicaule(ECN) on liver injury in mice was observed by using the mice model of intrahepatic cholestasis(IC) induced by α-naphthyl isothiocyanate(ANIT) and the possible mechanism by which ECN work as the therapeutic agent was discussed. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181101.001DOI Listing

Robotic choledochoduodenostomy for benign distal common bile duct stricture: how we do it.

J Robot Surg 2019 Apr 15. Epub 2019 Apr 15.

Digestive Health Institute, Florida Hospital Tampa, Tampa, USA.

Benign bile duct stricture poses a significant challenge for gastroenterologists and general surgeons due to the inherent nature of the disease, difficulty in sustaining long-term solutions and fear of pitfalls in performing biliary tract operations. Operative management with an open biliary bypass is mainly reserved for patients who have failed multiple attempts of endoscopic and percutaneous treatments. However, recent advances in minimally invasive technology, notably in the form of the robotics, have provided a new approach to tackling biliary disease. Read More

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http://link.springer.com/10.1007/s11701-019-00957-8
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http://dx.doi.org/10.1007/s11701-019-00957-8DOI Listing
April 2019
1 Read

A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer.

Surg Endosc 2019 Apr 15. Epub 2019 Apr 15.

Department of Hepato-Biliary and Pancreatic Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Background: The laparoscopic approach to liver resection has experienced exponential growth in recent years. However, evidence-based guidelines are needed for its safe future progression. The main aim of our study was to perform a systematic review and meta-analysis comparing the short- and long-term outcomes of laparoscopic and open liver resections for colorectal liver metastases (CRLM). Read More

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http://dx.doi.org/10.1007/s00464-019-06774-2DOI Listing
April 2019
1 Read

RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury.

Cell Death Differ 2019 Apr 15. Epub 2019 Apr 15.

Institute for Genetics, University of Cologne, D-50674, Cologne, Germany.

Hepatocyte apoptosis is intrinsically linked to chronic liver disease and hepatocarcinogenesis. Conversely, necroptosis of hepatocytes and other liver cell types and its relevance for liver disease is debated. Using liver parenchymal cell (LPC)-specific TGF-beta-activated kinase 1 (TAK1)-deficient (TAK1) mice, which exhibit spontaneous hepatocellular and biliary damage, hepatitis, and early hepatocarcinogenesis, we have investigated the contribution of apoptosis and necroptosis in hepatocyte and cholangiocyte death and their impact on liver disease progression. Read More

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http://www.nature.com/articles/s41418-019-0330-9
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http://dx.doi.org/10.1038/s41418-019-0330-9DOI Listing
April 2019
2 Reads

Preoperative and postoperative risk factors in laparoscopic cholecystectomy converted to open surgery.

Adv Clin Exp Med 2019 Apr 13. Epub 2019 Apr 13.

General Surgery Department, Atatürk Research and Education Hospital, Ankara, Turkey.

Background: Laparoscopic cholecystectomy (LC) is nowadays the gold standard in the surgical treatment of cholelithiasis and gallbladder diseases. But sometimes it may be inevitable to convert it to open surgery to safely end the procedure.

Objectives: In this study, we aimed to investigate the risk factors for conversion to open surgery from LC. Read More

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http://dx.doi.org/10.17219/acem/81519DOI Listing
April 2019
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Iatrogenic bile duct Injury with a retained T-tube in common bile duct for 10 years: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15127

Department of Pancreatic Surgery.

Rationale: Bile duct injury (BDI), a major complication of cholecystectomy, usually needs hepaticojejunostomy or primary repair over T-tube in severe cases. There were few cases about retained fragments of T-tube. Whereas, intact T-tube retained in common bile duct (CBD) for years after BDI was very rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000015127DOI Listing

An investigation into the sensitivity of endoscopic ultrasound in the diagnosis of malignant bile duct in patients with idiopathic acute pancreatitis.

J Family Med Prim Care 2019 Feb;8(2):733-737

Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.

Introduction And Objective: Acute pancreatitis (AP) is an inflammatory process of the pancreas characterized by abdominal pain and increased pancreatic enzymes. This disease is diagnosed clinically. Endoscopic ultrasound (EUS), which is a technique with high sensitivity and specificity, is used to diagnose biliary disease. Read More

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http://www.jfmpc.com/text.asp?2019/8/2/733/253065
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http://dx.doi.org/10.4103/jfmpc.jfmpc_463_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436311PMC
February 2019
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Right anatomical hepatectomy: pioneers, evolution, and the future.

Surg Today 2019 Apr 13. Epub 2019 Apr 13.

Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

To identify the pioneers of right anatomical hepatectomy (RAH), and clarify the development of associated operative procedures, concepts, and the future, we reviewed the "hidden" literature published in Eastern and Western countries since the 1940s. We searched the English and non-English literature on RAH through web search engines, text books and documents, and also referred to experts' comments. Non-English literature, other than in Japanese, was translated. Read More

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http://dx.doi.org/10.1007/s00595-019-01809-6DOI Listing

Ursodeoxycholic Acid Therapy and Liver Transplant-free Survival in Patients with Primary Biliary Cholangitis.

J Hepatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:

Background And Aims: The clinical efficacy of ursodeoxycholic acid (UDCA) in primary biliary cholangitis (PBC) remains subject to debate as definitive randomized controlled trials are lacking. We aimed to determine whether UDCA prolongs transplantation (LT) free survival in PBC.

Methods: This international cohort study included patients from the Global PBC Study Group database, originating from 8 countries in Europe and North America. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.04.001DOI Listing
April 2019
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Biliary atresia: a scientometric analysis of the global research architecture and scientific developments.

J Hepatobiliary Pancreat Sci 2019 Apr 12. Epub 2019 Apr 12.

Department of Pediatric Surgery, King's College Hospital, London, United Kingdom.

Biliary atresia (BA) is a rare cholangiopathy of largely unknown etiology and unpredictable outcome. There has been an increasing number of BA-related publications, which may challenge researchers to determine their actual scientific value. This study aimed to evaluate the global research activity and developments relating to BA using a combination of scientometric methodologies and visualization tools. Read More

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http://dx.doi.org/10.1002/jhbp.628DOI Listing
April 2019
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Radiological findings and surgical outcomes of pulmonary metastases originating from biliary tract carcinoma.

Gen Thorac Cardiovasc Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Purpose: Metastasis to the lungs arising from biliary tract carcinoma (BTC) is extremely rare, and the patient characteristics and prognosis are not well known. We aimed to identify the imaging findings of pulmonary metastases originating from BTC and the eligible indications for surgical treatment.

Methods: Fifteen patients who underwent pulmonary resection for metastases originating from BTC were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s11748-019-01122-6DOI Listing
April 2019
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Biliary-derived hepatocytes in chronic liver injury: Bringing new troops to the battlefield?

J Hepatol 2019 Apr 10. Epub 2019 Apr 10.

MRC Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, Edinburgh, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193018
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http://dx.doi.org/10.1016/j.jhep.2019.03.015DOI Listing
April 2019
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Combination versus mono-therapy as salvage treatment for advanced biliary tract cancer: A comprehensive meta-analysis of published data.

Crit Rev Oncol Hematol 2019 Jan 4. Epub 2019 Jan 4.

Department of Oncology, The Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing First Hospital, Nanjing, Jiangsu Province, 210006, China. Electronic address:

Aim: Gemcitabine-based chemotherapy regimens remain the standard first-line treatment for advanced biliary tract cancers (BTCs) patients with no second-line treatments established yet. The preset meta-analysis aims to comprehensively evaluate the role of second-line treatment for advanced BTCs in terms of response, overall survival and toxicities.

Materials And Methods: Eligible studies were identified using Medline, Pubmed, and meeting abstracts. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2019.01.001DOI Listing
January 2019

ASGE guideline on the role of endoscopy in the evaluation and management of choledocholithiasis.

Gastrointest Endosc 2019 Apr 9. Epub 2019 Apr 9.

Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA. Electronic address:

Each year choledocholithiasis results in biliary obstruction, cholangitis, and pancreatitis in a significant number of patients. The primary treatment, ERCP, is minimally invasive but associated with adverse events in 6% to 15%. This American Society for Gastrointestinal Endoscopy (ASGE) Standard of Practice (SOP) Guideline provides evidence-based recommendations for the endoscopic evaluation and treatment of choledocholithiasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165107183316
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http://dx.doi.org/10.1016/j.gie.2018.10.001DOI Listing
April 2019
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Effect of Liver Disease Etiology on ROTEM Profiles in Patients Undergoing Liver Transplantation.

Transplant Proc 2019 Apr 9;51(3):783-789. Epub 2019 Jan 9.

Department of Anaesthetics, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK.

Background: Coagulation abnormalities in liver transplant patients are complex and may be related to the underlying liver disease. We evaluated the effects of disease etiology on whole-blood rotational thromboelastometry (ROTEM; Pentapharm GmbH, Munich, Germany) profile and association with thrombotic complications following liver transplantation.

Methods: Analysis of perioperative data from patients undergoing liver transplantation between January 1, 2012 and December 31, 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183131
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http://dx.doi.org/10.1016/j.transproceed.2018.12.030DOI Listing
April 2019
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Ischemic Cholangiopathy: Insight From an Explant Liver Allograft Affected by Severe Post-transplant Hypoxemia Due to Hepatopulmonary Syndrome: A Case Report.

Transplant Proc 2019 Apr 9;51(3):1002-1005. Epub 2019 Jan 9.

Institute of Liver Disease and Transplantation, Gleneagles Global Health City, Chennai, India.

Increased biliary complications in hepatopulmonary syndrome (HPS) have been hypothesized due to post-transplant hypoxemia. Supporting this hypothesis, we report histopathological findings from an explant liver allograft where the recipient suffered severe and prolonged post-operative hypoxemia. A 4-year-old child underwent liver transplantation (LT) for decompensated chronic liver disease complicated by severe HPS. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.11.009DOI Listing

Percutaneous management of malignant biliary disease.

J Surg Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, Illinois.

Percutaneous biliary interventions have established their role in the management of benign and malignant biliary disease. There are limited data comparing procedures performed by gastroenterologists and interventional radiologists in managing malignant biliary obstruction. Endoscopic procedures performed by gastroenterologists are not completely benign with reported complications ranging from 2% to 15%. Read More

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http://dx.doi.org/10.1002/jso.25471DOI Listing
April 2019
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