75,020 results match your criteria Biliary Disease


The role of T-tubes and abdominal drains on short-term outcomes in liver transplantation - A systematic review of the literature and expert panel recommendations.

Clin Transplant 2022 May 21:e14719. Epub 2022 May 21.

Transplantation Center, Department of Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: This systematic review and expert panel recommendation aims to answer the question regarding the routine use of T-tubes or abdominal drains to better manage complications and thereby improve outcomes after liver transplantation.

Methods: Systematic review following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel to assess the potential risks and benefits of T-tubes and intra-abdominal drainage in liver transplantation (CRD42021243036).

Results: Of the 2996 screened records, 33 studies were included in the systematic review, of which 29 (6 RCT) assessed the use of T-tubes and 4 regarding surgical drains. Read More

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[The role of polymorphic variants rs11546155 and rs6119534 of the gene and risk factors in the development of acute pancreatitis].

Vopr Pitan 2022 14;91(2):43-50. Epub 2022 Mar 14.

Kursk State Medical University of the Ministry of Healthcfre of the Russian Federation, 305041, Kursk, Russian Federation.

Glutathione is an antioxidant with powerful restorative and detoxifying properties, a progressive decrease in its reserves in erythrocytes and pancreas observed in pancreatic necrosis indicates a lack of functioning of the system for maintaining the level of glutathione in cells and the use of its endogenous reserve. The study of the role of glutathione metabolism enzyme genes in the risk of acute pancreatitis in this regard is especially relevant. of the study was to evaluate the joint contribution of the rs11546155 and rs6119534 polymorphic loci of the GGT7 gene and some risk factors to the development of acute pancreatitis (AP). Read More

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Prevalence and clinical features of patients with autoimmune pancreatitis and inflammatory bowel disease: A systematic review and meta-analysis.

J Gastroenterol Hepatol 2022 May 20. Epub 2022 May 20.

Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Background And Aim: Autoimmune pancreatitis (AIP) and inflammatory bowel disease (IBD) are categorized into immune-mediated inflammatory disorders (IMIDs). While AIP is a pancreato-biliary IMID with an increased incidence and prevalence among patients with IBD, its features are still unclear. This systematic review and meta-analysis aims to assess the prevalence and clinical characteristics of AIP-IBD patients. Read More

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Meckel's diverticulum causing acute intestinal obstruction: A case report and comprehensive review of the literature.

Ann Med Surg (Lond) 2022 Jun 7;78:103734. Epub 2022 May 7.

Division of Gastroenterology and Liver Disease, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.

Introduction: Meckel's diverticulum is a congenital anomaly that is often detected incidentally. When it presents symptomatically, it causes painless gastrointestinal bleeding. Nevertheless, in rare instances, it can cause acute intestinal obstruction, often obscuring the true clinical picture. Read More

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Diagnostic criteria for acute-on-chronic liver failure and related disease conditions in Japan.

Hepatol Res 2022 May;52(5):417-421

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

The Intractable Hepato-Biliary Disease Study Group of Japan, sponsored by the Ministry of Health, Labor and Wealth, proposed in 2018 that patients with cirrhosis and a Child-Pugh score of 5-9 should be diagnosed as having acute-on-chronic liver failure (ACLF) when a deterioration of liver function ("serum bilirubin level of 5.0 mg/dl or more" and "prothrombin time value of 40% or less of the standardized values and/or international normalization rates of 1.5 or more") caused by severe liver damage develops within 28 days after an acute insult, including alcohol abuse, bacterial infection, gastrointestinal bleeding, and the exacerbation of underlying liver diseases. Read More

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Multiple biochemical indices and metabolomics of Clonorchis sinensis provide a novel interpretation of biomarkers.

Parasit Vectors 2022 May 19;15(1):172. Epub 2022 May 19.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130012, Jilin Province, China.

Background: Clonorchiasis, an infectious disease caused by the liver fluke Clonorchis sinensis, may lead to the development of liver and gallbladder diseases, and even cholangiocarcinoma (CCA). However, the pathogenesis, host-pathogen interaction, and diagnostic markers for clonorchiasis remain unclear.

Methods: Eighteen rabbits were randomly divided into control group (n = 9) and C. Read More

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Safety and efficacy of holmium-166 radioembolization in hepatocellular carcinoma - the HEPAR Primary study.

J Nucl Med 2022 May 19. Epub 2022 May 19.

University Medical Center Utrecht, Netherlands.

Hepatocellular carcinoma (HCC) is the sixth most common cancer and second in cancer-related deaths. Radioembolization using holmium-166 (Ho)-microspheres is new in the HCC treatment landscape. Safety and efficacy of Ho-radioembolization was first determined in the HEPAR and HEPAR II studies, however excluding patients with HCC. Read More

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F-Fluorodihydroxyphenylalanine PET/CT at the Forefront for Initial and/or Pre-surgical Evaluation of Small Intestine Neuroendocrine Tumors.

J Nucl Med 2022 May 19. Epub 2022 May 19.

Nuclear Medicine and Molecular Imaging, Institut de Cancérologie Strasbourg Europe (ICANS), France.

To compare the respective value of Ga-DOTATOC and F-DOPA PET/CT for initial staging or pre-surgical work-up of patients with small intestine neuroendocrine tumors (SiNET). This is a retrospective, multicenter, non-interventional investigation involving 53 non-operated SiNET patients who underwent both Ga-DOTATOC and F-DOPA PET/CT within a 6-months interval without therapeutic intervention or change between the two PET/CT studies. Detection rate (DR %) was calculated according to per-region and per-lesion analyses. Read More

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Social media communities for patients and families affected by congenital pediatric surgical conditions.

Pediatr Surg Int 2022 May 19. Epub 2022 May 19.

International Center for Colorectal and Urogenital Care, Division of Pediatric Surgery, Anschutz Medical Campus, Children's Hospital Colorado, 13213 E 16th Ave, Box 323, Aurora, CO, 80045, USA.

Background: Social media has become a means to allow individuals affected by rare diseases to connect with others. This study aimed to characterize the use of three popular social media platforms by individuals affected by common pediatric surgery index conditions.

Methods: A systematic search of Instagram, Facebook, and Twitter was performed using standardized terms for the following pediatric surgical conditions: anorectal malformation, biliary atresia, bronchopulmonary sequestration, congenital diaphragmatic hernia (CDH), congenital pulmonary airway malformation, duodenal atresia, esophageal atresia/tracheoesophageal fistula (EA/TEF), gastroschisis, Hirschsprung disease (HD), and omphalocele. Read More

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Design and Development of a Disposable Superfine Catheter for Visual Examination of Bile Ducts and Related Animal Experiments.

Front Surg 2022 2;9:877040. Epub 2022 May 2.

Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.

Objective: To design and develop a disposable superfine catheter system for visual examination of bile and pancreatic ducts and predict its clinical application value.

Methods: The superfine triple-lumen catheter and miniature photography technology were used to design and produce a disposable superfine catheter for visual examination of bile and pancreatic ducts, and animal experiments were conducted to compare said catheter and SpyGlass™.

Results: The designed and developed disposable superfine catheter for visual examination of bile ducts with a diameter of 2. Read More

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Is the tumor-stroma ratio a prognostic factor in gallbladder cancer?

Rev Assoc Med Bras (1992) 2022 May;68(5):664-669

University of Health Sciences Turkey, Haydarpasa Numune Training and Research Hospital, Department of General Surgery - Istanbul, Turkey.

Objective: This study aimed to examine the prognostic effect of the tumor-stroma ratio, which has been shown to have prognostic value in various cancers, in patients with gallbladder cancer who have undergone curative resection.

Methods: The records of gallbladder cancer patients who underwent surgical treatment in our clinic between December 2005 and March 2021 were analyzed retrospectively. The hematoxylin and eosin-stained sections representing the tumors were evaluated under light microscopy to determine tumor-stroma ratio, and based on the results, <50% was defined as the stroma-rich and ≥50% as the stroma-poor groups. Read More

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Osteosarcopenia in autoimmune cholestatic liver diseases: Causes, management, and challenges.

World J Gastroenterol 2022 Apr;28(14):1430-1443

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele 20090, Milan, Italy.

Primary biliary cholangitis and primary sclerosing cholangitis (PSC) are the most common cholestatic liver diseases (CLD) in adults and are both characterized by an immune pathogenesis. While primary biliary cholangitis is a model autoimmune disease, with over 90% of patients presenting very specific autoantibodies against mitochondrial antigens, PSC is considered an immune mediated disease. Osteoporosis is the most common bone disease in CLD, resulting in frequent fractures and leading to significant morbidity. Read More

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Pediatric liver transplantation outcomes from a single center in Thailand.

World J Hepatol 2022 Mar;14(3):583-591

Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.

Background: Liver transplantation (LT) has become an acceptable curative method for children with several liver diseases, especially irreversible acute liver failure and chronic liver diseases. King Chulalongkorn Memorial Hospital is one of Thailand's largest liver transplant centers and is responsible for many pediatric cases.

Aim: To report the experience with pediatric LT and evaluate outcomes of living-related deceased-donor grafts. Read More

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Small duct primary sclerosing cholangitis: A discrete variant or a bridge to large duct disease, a practical review.

World J Hepatol 2022 Mar;14(3):495-503

Department of Gastroenterology and Hepatology, The University of Texas Medical Branch, Galveston, TX 77555, United States.

The natural history, associations with inflammatory bowel disease (IBD), and long-term outcomes of large duct primary sclerosing cholangitis (ldPSC) have been well documented. Small duct primary sclerosing cholangitis (sdPSC) is a much less common and relatively more benign variant. The natural history of sdPSC has been difficult to characterize given the limited number of studies in the literature especially with regards to the subset of patients who progress to large duct involvement. Read More

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Novel approaches in search for biomarkers of cholangiocarcinoma.

World J Gastroenterol 2022 Apr;28(15):1508-1525

Department of Histology, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania.

Cholangiocarcinoma (CCA) arises from the ductular epithelium of the biliary tree, either within the liver (intrahepatic CCA) or more commonly from the extrahepatic bile ducts (extrahepatic CCA). This disease has a poor prognosis and a growing worldwide prevalence. The poor outcomes of CCA are partially explained by the fact that a final diagnosis is challenging, especially the differential diagnosis between hepatocellular carcinoma and intrahepatic CCA, or distal CCA and pancreatic head adenocarcinoma. Read More

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Evaluating the accuracy of American Society for Gastrointestinal Endoscopy guidelines in patients with acute gallstone pancreatitis with choledocholithiasis.

World J Gastroenterol 2022 Apr;28(16):1692-1704

Division of Gastroenterology & Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.

Background: Acute gallstone pancreatitis (AGP) is the most common cause of acute pancreatitis (AP) in the United States. Patients with AGP may also present with choledocholithiasis. In 2010, the American Society for Gastrointestinal Endoscopy (ASGE) suggested a management algorithm based on probability for choledocholithiasis, recommending additional imaging for patients at intermediate risk and endoscopic retrograde cholangiopancreatography (ERCP) for patients at high risk of choledocholithiasis. Read More

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Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis.

Cell Death Discov 2022 May 17;8(1):265. Epub 2022 May 17.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Gallbladder cancer is the most common biliary tract malignant tumor with highly metastatic characters and poor prognosis. However, the underlying mechanism remains unclear. Stathmin1 is ubiquitous phosphoprotein, regulating microtubule stabilization. Read More

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IgG4-Related Pancreato-Biliary Disease in the Disguise of Malignancy.

Am Surg 2022 May 16:31348221102610. Epub 2022 May 16.

Deptartment of Surgical Gastroenterology, 442339All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

The Immunoglobulin G4-related disease (IgG4-RD) is a multisystem inflammatory condition. Pancreaticobiliary manifestations often present as mass lesions that mimic malignancies. The diagnosis is confirmed by histopathological examination, that shows lymphoplasmacytic infiltration, storiform fibrosis, obliterative phlebitis, and positive immunohistochemistry for IgG4. Read More

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Anicteric Gallbladder Rupture with Elevated Bile Acids in Abdominal Effusion in a Dog with Cholecystitis.

J Am Anim Hosp Assoc 2022 May;58(3):146-151

From Dick White Referrals, Cambridgeshire, United Kingdom.

Anicteric gallbladder rupture has been rarely described in veterinary medicine, and, generally, it has been related to gallbladder wall necrosis secondary to gallbladder mucocele. A 5 yr old, male, neutered Labrador retriever presented for acute onset anorexia, lethargy, and vomiting. Cholecystitis was diagnosed based on the ultrasonographic findings and bactibilia, and, consequently, medical treatment was established. Read More

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Core outcome set for symptomatic uncomplicated gallstone disease.

Br J Surg 2022 May;109(6):539-544

Health Services Research Unit, University of Aberdeen Institute of Applied Health Sciences, Aberdeen, UK.

Background: Heterogeneity of outcomes is a problem for assessing intervention effectiveness when considering treatments for uncomplicated symptomatic gallstone disease. The value to all stakeholders of outcomes that have been measured and reported to date is also unclear. The aim of this study was to develop a core outcome set for symptomatic uncomplicated gallstone disease. Read More

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Analysis of Targeted Post-operative Nursing Outcome in 1246 Patients with Percutaneous Transhepatic Biliary Drainage.

Front Surg 2022 27;9:908909. Epub 2022 Apr 27.

Department of Interventional Vascular Surgery, Hunan Provincial People's Hospital (The first-affiliated hospital of Hunan normal university), Changsha, China.

Jaundice is a detection index in many disease conditions commonly characterized by yellowish staining of the skin and mucous membranes. This work studies the postoperative care outcome in 1,246 patients (669 males and 577 females) with obstructive jaundice who underwent percutaneous transhepatic biliary drainage (PTBD). These patients were admitted to the interventional vascular surgery department of our hospital from February 2017 to February 2022. Read More

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A New SteatoScore in the Evaluation of Non-Alcoholic Liver Disease in Oncologic Patients.

Front Oncol 2022 27;12:873524. Epub 2022 Apr 27.

Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy.

Purpose: The aims of this study were to evaluate the reproducibility of a new multi-parametric steatoscore (new SteatoScore) in oncologic patients with non-alcoholic fatty liver disease (NAFLD) and to compare it with computed tomography (CT).

Materials And Methods: Fifty-one (31 men, 20 women) oncologic patients, with a mean age and weight of 63.9 years and 78. Read More

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Pharmacokinetics, distribution, and excretion of sodium oligomannate, a recently approved anti-Alzheimer's disease drug in China.

J Pharm Anal 2022 Feb 5;12(1):145-155. Epub 2021 Jun 5.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215021, China.

The National Medical Products Administration has authorized sodium oligomannate for treating mild-to-moderate Alzheimer's disease. In this study, an LC-MS/MS method was developed and validated to quantitate sodium oligomannate in different biomatrices. The plasma pharmacokinetics, tissue distribution, and excretion of sodium oligomannate in Sprague-Dawley rats and beagle dogs were systematically investigated. Read More

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February 2022

TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases.

Front Mol Biosci 2022 28;9:895814. Epub 2022 Apr 28.

Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China.

Transient receptor potential (TRP) channels are polymodal channels capable of sensing environmental stimuli, which are widely expressed on the plasma membrane of cells and play an essential role in the physiological or pathological processes of cells as sensors. TRPs often form functional homo- or heterotetramers that act as cation channels to flow Na and Ca, change membrane potential and [Ca] (cytosolic [Ca]), and change protein expression levels, channel attributes, and regulatory factors. Under normal circumstances, various TRP channels respond to intracellular and extracellular stimuli such as temperature, pH, osmotic pressure, chemicals, cytokines, and cell damage and depletion of Ca reserves. Read More

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Robotic Diagnosis and Management of Acute Cholecystocolonic Fistula.

Cureus 2022 Apr 13;14(4):e24101. Epub 2022 Apr 13.

Trauma and Acute Care Surgery, Methodist Health System, Dallas, USA.

Cholecystocolonic fistula (CCF) is a rare complication of biliary tract disease. Increased use of imaging has aided in diagnosing these fistulae preoperatively and has established laparoscopy as a safe alternative to laparotomy. Here, we present a 79-year-old male who presented to the emergency room with abdominal pain and was diagnosed with choledocholithiasis. Read More

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Variants Disrupting CD40L Transmembrane Domain and Atypical X-Linked Hyper-IgM Syndrome: A Case Report With Leishmaniasis and Review of the Literature.

Front Immunol 2022 28;13:840767. Epub 2022 Apr 28.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

X-linked hyper-IgM (XHIGM) syndrome is caused by mutations of the CD40LG gene, encoding the CD40L protein. The clinical presentation is characterized by early-onset infections, with profound hypogammaglobulinemia and often elevated IgM, susceptibility to opportunistic infections, such as pneumonia, biliary tract disease due to , and malignancy. We report a 41-year-old male presenting with recurrent leishmaniasis, hypogammaglobulinemia, and myopathy. Read More

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The NOD Mouse Beyond Autoimmune Diabetes.

Front Immunol 2022 29;13:874769. Epub 2022 Apr 29.

Immunology-Oncology Division, Maisonneuve-Rosemont Hospital Research Center, Montreal, QC, Canada.

Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the pathophysiology of this disease shares many similarities with human type 1 diabetes. Since its generation in 1980, the NOD mouse, derived from the Cataract Shinogi strain, has represented the gold standard of spontaneous disease models, allowing to investigate autoimmune diabetes disease progression and susceptibility traits, as well as to test a wide array of potential treatments and therapies. Beyond autoimmune diabetes, NOD mice also exhibit polyautoimmunity, presenting with a low incidence of autoimmune thyroiditis and Sjögren's syndrome. Read More

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Asymptomatic gangrenous cholecystitis diagnosed using contrast-enhanced ultrasonography in a patient with pancreatic cancer.

Radiol Case Rep 2022 Jul 5;17(7):2309-2314. Epub 2022 May 5.

Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, Okayama, Japan.

A 72-year-old female without abdominal symptoms visited our hospital for routine follow-up while undergoing pancreatic cancer treatment (using TS-1). Her vital signs were normal, and her abdomen was soft and non-tender. Blood test revealed elevated C-reactive protein levels with normal white blood cell count. Read More

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Our Pediatric Liver and Kidney Transplant Activities in 2021.

Exp Clin Transplant 2022 May;20(Suppl 3):85-88

From the Baskent University, Department of General Surgery, Division of Transplantation, Ankara, Turkey.

Objectives: In children with end-stage renal disease, chronic liver failure, or acute liver failure, liver transplant and kidney transplant are the most effective modalities for better clinical outcomes compared with other therapies. However, children are particularly susceptible to surgical complications, so pediatric solid-organ transplants should be reserved for centers with substantial experience and multidisciplinary expertise. Here, we assessed liver and kidney transplants performed at our center in 2021. Read More

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