752 results match your criteria Biliary Atresia Imaging


Minimally invasive assessment of hepatic function in children with indocyanine green elimination: a validation study.

Scand J Gastroenterol 2019 Mar 29:1-7. Epub 2019 Mar 29.

e Department of Clinical Physiology, Nuclear Medicine and PET , Copenhagen University Hospital, Rigshospitalet , Copenhagen Ø , Denmark.

Objectives: Pediatric liver disease (PLD) covers a variety of etiologies and severities, from mild temporary illness to diseases with fatal outcomes. There is a demand for minimally invasive and reliable measures for assessment of the severity of PLD. Indocyanine green (ICG) elimination kinetics to estimate hepatic function has been used in adults for decades, however, due to invasiveness, the use in PLD is still limited. Read More

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http://dx.doi.org/10.1080/00365521.2019.1591497DOI Listing
March 2019
1 Read

Noninvasive Evaluation of Liver Fibrosis and Portal Hypertension After Successful Portoenterostomy for Biliary Atresia.

Hepatol Commun 2019 Mar 9;3(3):382-391. Epub 2019 Jan 9.

Pediatric Liver and Gut Research Group and Section of Pediatric Surgery Children's Hospital, Helsinki University Hospital Helsinki Finland.

We investigated noninvasive follow-up markers for histologic liver fibrosis and portal hypertension (PH) in patients with biliary atresia after successful portoenterostomy (PE). Among children with bilirubin <20 µmol/L after PE (n = 39), Metavir fibrosis stage was evaluated at PE and in follow-up protocol liver biopsies (n = 83). PH was defined as endoscopically confirmed esophageal varices or thrombocytopenia associated with splenomegaly. Read More

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http://dx.doi.org/10.1002/hep4.1306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396371PMC
March 2019
1 Read

Magnetic resonance imaging of fibropolycystic liver disease: the spectrum of ductal plate malformations.

Abdom Radiol (NY) 2019 Mar 9. Epub 2019 Mar 9.

Radiology Unit, Department of Diagnostic and Therapeutic Services, IRCCS ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Via Tricomi 5, 90127, Palermo, Italy.

Fibropolycystic liver diseases, also known as ductal plate malformations, are a group of associated congenital disorders resulting from abnormal development of the biliary ductal system. These disorders include congenital hepatic fibrosis, biliary hamartomas, polycystic liver disease, choledochal cysts and Caroli disease. Recently, it has been thought to include biliary atresia in this group of diseases, because ductal plate malformations could be implicated in the pathogenesis of this disease. Read More

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http://dx.doi.org/10.1007/s00261-019-01966-9DOI Listing
March 2019
2 Reads

A case report of a challenging diagnosis of biliary atresia in a patient receiving total parenteral nutrition.

BMC Pediatr 2019 Mar 8;19(1):72. Epub 2019 Mar 8.

Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Background: Total parenteral nutrition (TPN) and biliary atresia (BA) are common causes of cholestasis in infancy. The diagnosis of BA is time sensitive due to an inverse correlation between age at intervention (hepatic portoenterostomy - HPE) and survival without liver transplantation. Clinical, laboratory, and histologic features of BA and parenteral nutrition associated cholestasis (PNAC) are similar, creating a diagnostic dilemma for cholestatic infants on parenteral nutrition. Read More

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http://dx.doi.org/10.1186/s12887-019-1446-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407171PMC
March 2019
1 Read

Abernethy Malformation Type 2 and Biliary Atresia Coexistence: A Rare Cause of Infantile Liver Transplant.

Euroasian J Hepatogastroenterol 2018 Jul-Dec;8(2):163-166. Epub 2019 Feb 1.

Department of Neonatology, Dr. BehCet Uz Pediatric Diseases and Surgery Education Research Hospital, Izmir, Turkey.

Introduction: Abernethy malformation is a very rare condition in which mesenteric venous blood is drained into systemic circulation by an extra hepatic portosystemic shunt. Here we present a case of a female in infantile period who is a liver transplant candidate with biliary atresia and ventricular septal defect (VSD) accompanying Abernethy malformation type 2.

Case Report: The patient who underwent Kasai operation at postnatal day 35 was identified as a liver transplant candidate in the postnatal month 6 due to growth retardation in the infantile period, insufficient weight gain and liver failure (portal hypertension and massive gastrointestinal bleeding). Read More

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http://dx.doi.org/10.5005/jp-journals-10018-1283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395480PMC
February 2019
1 Read

Neonatal Jaundice.

Indian J Pediatr 2019 Feb 21. Epub 2019 Feb 21.

Department of Radio-Diagnosis, All India Institute of Medical Sciences, New Delhi, India.

Hyperbilirubinemia is a common occurrence in neonates; it may be physiological or pathological. Conjugated hyperbilirubinemia may result from medical or surgical causes, and can result in irreversible liver damage if untreated. The aim of imaging is the timely diagnosis of surgical conditions like biliary atresia and choledochal cysts. Read More

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http://link.springer.com/10.1007/s12098-019-02856-0
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http://dx.doi.org/10.1007/s12098-019-02856-0DOI Listing
February 2019
4 Reads

Ultrasound findings in paediatric cholestasis: how to image the patient and what to look for.

J Ultrasound 2019 Feb 12. Epub 2019 Feb 12.

Department of Radiology, "Federico II" University Hospital, Naples, Italy.

Paediatric biliary tract and gallbladder diseases include a variety of entities with a wide range of clinical presentations. Cholestasis represents an impaired secretion of bilirubin by hepatocytes, manifesting with high blood levels of conjugated bilirubin and jaundice. Various causes may be involved, which can be recognised analysing blood tests and hepatobiliary imaging, while sometimes liver biopsy or surgery may be necessary. Read More

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http://dx.doi.org/10.1007/s40477-019-00362-9DOI Listing
February 2019
5 Reads

Design and validation of a noninvasive diagnostic criteria for biliary atresia in infants based on the STROBE compliant.

Medicine (Baltimore) 2019 Feb;98(6):e13837

Department of Infection, The Second Affiliated Hospital of Xi'an Jiaotong University.

It is difficult for clinicians to distinguish biliary atresia (BA) from other causes of neonatal cholestasis (NC) at an early stage. The aim of this study was to design and validate noninvasive diagnostic criterion for early diagnosis of BA in infants.In this retrospective cohort study, a total of 482 medical records of patients with NC were recruited to design diagnostic criteria. Read More

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http://dx.doi.org/10.1097/MD.0000000000013837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380858PMC
February 2019
1 Read

Technical Feasibility and Clinical Effectiveness of Transjugular Intrahepatic Portosystemic Shunt Creation in Pediatric and Adolescent Patients.

J Vasc Interv Radiol 2019 02;30(2):178-186.e5

Division of Interventional Radiology, Department of Radiology, University of Washington, Seattle, Washington; Seattle Children's Hospital, Seattle, Washington.

Purpose: To examine the technical feasibility and clinical efficacy of transjugular intrahepatic portosystemic shunt (TIPS) creation in children and adolescents.

Materials And Methods: Retrospective review was performed of 59 patients (mean age 12.6 y [range, 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10510443183158
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http://dx.doi.org/10.1016/j.jvir.2018.10.003DOI Listing
February 2019
4 Reads
2.149 Impact Factor

Predicting gastroesophageal varices through spleen magnetic resonance elastography in pediatric liver fibrosis.

World J Gastroenterol 2019 Jan;25(3):367-377

Department of Radiology, Severance Hospital, Severance Pediatric Liver Disease Research Group, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 03722, South Korea.

Background: A recent retrospective study confirmed that hepatic stiffness and splenic stiffness measured with magnetic resonance elastography (MRE) are strongly associated with the presence of esophageal varices. In addition, strong correlations have been reported between splenic stiffness values measured with MRE and hepatic venous pressure gradients in animal models. However, most studies have been conducted on adult populations, and previous pediatric MRE studies have only demonstrated the feasibility of MRE in pediatric populations, while the actual clinical application of spleen MRE has been limited. Read More

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https://www.wjgnet.com/1007-9327/full/v25/i3/367.htm
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http://dx.doi.org/10.3748/wjg.v25.i3.367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343098PMC
January 2019
10 Reads

Biliary Atresia-associated Cholangitis: The Central Role and Effective Management of Bile Lakes.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):488-494

Section of Pediatric Surgery, Pediatric Liver and Gut Research Group and Pediatric Research Center, Children's Hospital, Helsinki University Hospital.

Objectives: Cholangitis and bile lakes are incompletely understood complications after portoenterostomy (PE). We investigated relationships between recurrent cholangitis, bile lakes, and clinical outcomes as well as surgical management of bile lakes.

Methods: In this retrospective observational single institution study medical records and imaging studies of all patients who had undergone PE for biliary atresia during 1987 to 2016 (N = 61) were reviewed. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002243DOI Listing
April 2019
2 Reads

Outcome of biliary atresia among Saudi children: A tertiary care center experience.

Saudi J Gastroenterol 2018 Nov 27. Epub 2018 Nov 27.

Division of Pediatric Gastroenterology, Department of Pediatric Sub-Specialities, The Children's Specialized Hospital, King Fahad Medical City; College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.

Background/aims: Data from Western countries indicate that biliary atresia (BA) is the leading cause of end-stage liver disease in children and the most common indication for liver transplantation (LT) in the pediatric population. There is no data on the epidemiology and outcome of BA in Saudi Arabia. The main objective of our study was to understand the clinical and epidemiological characteristics and outcome of BA in the Saudi population. Read More

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http://dx.doi.org/10.4103/sjg.SJG_306_18DOI Listing
November 2018
19 Reads

The Triangular Sign, a Useful Diagnostic Marker for Biliary Atresia: A Case Series of Three Irish Infants

Ir Med J 2018 Jun 7;111(6):776. Epub 2018 Jun 7.

Department of Neonatology, The Rotunda Hospital, Dublin

Background The triangular cord (TC) sign is the appearance of a triangular shaped echogenic density visualised immediately cranial to the portal vein bifurcation on ultrasonographic examination. Several studies have reported that this ultrasonographic sign is a reliable and helpful marker in identifying Biliary Atresia (BA). Aims To report the identification of the TC sign in three infants with BA in the Rotunda Hospital, Dublin. Read More

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June 2018
2 Reads

A quantitative image analysis using MRI for diagnosis of biliary atresia.

Clin Imaging 2019 Jan - Feb;53:186-190. Epub 2018 Oct 12.

Mackay Junior College of Medicine, Nursing, and Management, Taipei City 11260, Taiwan, ROC; Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan, ROC; Department of Radiology, MacKay Memorial Hospital, Taipei City 10449, Taiwan, ROC. Electronic address:

Purpose: Biliary atresia is a life-threatening disease that needs early diagnosis and management. Recently, MRI images have been used for the diagnosis of biliary atresia with improved accuracy of diagnosis when other imaging modalities such as ultrasonography are equivocal. This study aimed to evaluate the juxta-hilar extrahepatic biliary tree using MRI images to determine a quantitative value for diagnosing biliary atresia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08997071183026
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http://dx.doi.org/10.1016/j.clinimag.2018.10.001DOI Listing
March 2019
18 Reads

Living donor liver transplantation and situs inversus totalis: cutting the Gordian knot.

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Institute of Liver Disease & Transplantation, Gleneagles Global Health City Chennai, Chennai, Tamil Nadu, India.

Liver transplantation for biliary atresia splenic malformation syndrome associated with situs inversus totalis is a challenging task due to the complexity of associated malformations and the technical proficiency required to overcome them. We present the case of a 6-month-old infant who underwent liver transplantation for biliary atresia. A reduced left lateral segment liver graft from a live donor (his mother) was implanted. Read More

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http://dx.doi.org/10.1136/bcr-2018-226222DOI Listing
October 2018
3 Reads

Experimentally induced biliary atresia by means of rotavirus-infection is directly linked to severe damage of the microvasculature in the extrahepatic bile duct.

Anat Rec (Hoboken) 2018 Oct 12. Epub 2018 Oct 12.

Department of Pediatric Surgery, Medizinische Hochschule Hannover, Hannover, Germany.

Aim: Vascular damage has been reported to contribute to atresia formation in several diseases including biliary atresia. This study focused on the extrahepatic biliary plexus in experimental biliary atresia.

Methods: Newborn BALB/cAnNCrl-pups were infected with rhesus rotavirus within 24 hours after birth to induce experimental biliary atresia. Read More

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http://doi.wiley.com/10.1002/ar.23974
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http://dx.doi.org/10.1002/ar.23974DOI Listing
October 2018
7 Reads

Using Tc-DTPA galactosyl human serum albumin liver scintigraphy as a prognostic indicator in jaundice-free patients with biliary atresia.

J Pediatr Surg 2018 Dec 7;53(12):2412-2415. Epub 2018 Sep 7.

Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: We evaluated the clinical significance of follow-up data, including Tc-DTPA galactosyl human serum albumin (Tc-GSA) liver scintigraphy data, as prognostic indicators for jaundice-free patients with biliary atresia (BA).

Methods: Of 87 patients who underwent Kasai portoenterostomy (KP) between 1991 and 2012, 45 jaundice-free patients aged 1-2 years underwent Tc-GSA scintigraphy and were classified into 2 groups: those who survived with a native liver (Group A, n = 34) and those who required liver transplantation (LTx) (Group B, n = 11). We compared Tc-GSA scintigraphy data (HH15, LHL15, and HH15/LHL15 [H/L15]) and liver function test (LFT) results between the groups. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.08.032DOI Listing
December 2018
3 Reads

Successful percutaneous transhepatic recanalization of a completely obstructed hepatico-jejunal anastomosis in a child with liver transplantation: Unusual employment of the transseptal puncture system.

Pediatr Transplant 2018 12 23;22(8):e13293. Epub 2018 Sep 23.

Department of Imaging, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Stenosis of the HJ is a common complication of pediatric split LT with high morbidity and possible evolution to secondary biliary cirrhosis and re-transplantation if not treated. Because the endoscopy is generally infeasible in the Roux-en-Y, percutaneous interventional radiology management is usually the safest and most effective approach to avoid surgical revision of a stenotic bilio-enteric anastomosis. We present the case of a child with acute onset of cholestasis 7 months after left lateral segment partial LT due to occlusion of the HJ. Read More

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http://dx.doi.org/10.1111/petr.13293DOI Listing
December 2018
1 Read

The Double Trouble: A Case of Duplicated Extrahepatic Bile Duct with Choledochal Cyst.

Indian J Pediatr 2019 Feb 12;86(2):186-188. Epub 2018 Sep 12.

Department of Radiodiagnosis, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Biliary tract shows a large number of anatomic variations and duplication of the bile duct is an extremely rare anomaly. It has been reported to be associated with other congenital conditions like Abnormal Pancreato Biliary Junction (APBJ), biliary atresia and choledochal cyst and may lead to complications like cholangitis, choledocholithiasis and malignancy. The clinical presentation may be with one of the above complications and the condition usually reveals itself only on imaging investigations, as a surprise to the radiologist and the surgeon. Read More

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http://dx.doi.org/10.1007/s12098-018-2790-1DOI Listing
February 2019
7 Reads

Ultrasound Elastography Applications in Pediatrics.

Ultrasound Q 2018 Dec;34(4):199-205

Children's Mercy Hospital, Kansas City, MO.

Ultrasound is one of the most important imaging modalities in pediatric imaging because of its accessibility, portability, lack of ionizing radiation, and ability to generally perform examinations without need for sedation. Ultrasound elastography can measure the stiffness of various tissues. This review article aims to discuss how ultrasound elastography has performed in evaluating multiple pathologies in the pediatric population. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000379DOI Listing
December 2018
11 Reads

Clinical Features and Genetic Analysis of Pediatric Patients with Alagille Syndrome Presenting Initially with Liver Function Abnormalities.

Curr Med Sci 2018 Apr 30;38(2):304-309. Epub 2018 Apr 30.

Department of Pediatrics, Huazhong University of Science and Technology, Wuhan, 430030, China.

Alagille syndrome (AGS) is a multisystem disorder and caused by mutations in JAG1 or NOTCH2 gene. The diagnosis of AGS is hampered by its highly variable clinical manifestations. We performed a retrospective analysis on 16 children diagnosed as having AGS in recent five years in our hospital. Read More

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http://dx.doi.org/10.1007/s11596-018-1879-0DOI Listing
April 2018
2 Reads

Clinical Assessment of Differential Diagnostic Methods in Infants with Cholestasis due to Biliary Atresia or Non-Biliary Atresia.

Curr Med Sci 2018 Feb 15;38(1):137-143. Epub 2018 Mar 15.

Department of Pediatrics, Wuhan, 430030, China.

The different methods in differentiating biliary atresia (BA) from non-BA-related cholestasis were evaluated in order to provide a practical basis for a rapid, early and accurate differential diagnosis of the diseases. 396 infants with cholestatic jaundice were studied prospectively during the period of May 2007 to June 2011. The liver function in all subjects was tested. Read More

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http://dx.doi.org/10.1007/s11596-018-1857-6DOI Listing
February 2018
6 Reads

A Novel Case of Biliary Atresia in a Premature Neonate With 1p36 Deletion Syndrome.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618790613. Epub 2018 Jul 24.

University of Nevada, Las Vegas, NV, USA.

We describe the case of a premature male neonate diagnosed with biliary atresia who was found to have chromosome 1p36 deletion syndrome. Our patient was born prematurely, at a gestational age of 28 weeks. Pregnancy was complicated by advanced maternal age, gestational hypertension, and intrauterine growth restriction. Read More

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http://dx.doi.org/10.1177/2324709618790613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058419PMC
July 2018
3 Reads

Prevalence and characteristics of hepatopulmonary syndrome in children with cirrhosis in southern Brazil.

Eur J Gastroenterol Hepatol 2019 01;31(1):10-15

Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil.

Background: Hepatopulmonary syndrome (HPS) is defined as a triad characterized by arterial deoxygenation, intrapulmonary vascular dilatations (IPVDs), and liver disorder. The aims of this study were to assess the prevalence of HPS in children with cirrhosis, the clinical characteristics of patients with HPS, and the tests used for the diagnosis of IPVD.

Patients And Methods: This was a prospective, cross-sectional study of 40 children with cirrhosis (median age: 44 months). Read More

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http://dx.doi.org/10.1097/MEG.0000000000001207DOI Listing
January 2019
5 Reads

Rebound thymic hyperplasia after liver transplantation for a child with biliary atresia; a case report.

Pediatr Transplant 2018 Jul 24:e13251. Epub 2018 Jul 24.

Department of Surgery, Liver Transplantation Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

The thymus gland possesses the ability to regrow in children leading to a newly developed anterior mediastinal mass. This condition may represent a rebound phenomenon during recovery from a stressful event such as post-chemotherapy and hence was described as RTH. RTH after LT has not been well documented. Read More

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http://dx.doi.org/10.1111/petr.13251DOI Listing
July 2018
6 Reads

Cystic biliary atresia: A distinct clinical entity that may mimic choledochal cyst.

Radiol Case Rep 2018 Apr 9;13(2):415-418. Epub 2018 Feb 9.

Department of Pediatrics, Duke University Medical Center, DUMC 102375, Hanes House Rm 370, Durham, NC 27710, USA.

Cystic biliary atresia (CBA) is a relatively uncommon but clinically significant variant of biliary atresia. The presence of a cyst in the hepatic hilum on imaging in an infant with cholestasis supports the diagnosis of CBA, but can also be seen in patients with a choledochal cyst-the main differential diagnosis in patients with CBA. The reported case outlines the clinical presentation and imaging findings in a patient with surgically confirmed and treated CBA and emphasizes the importance of distinguishing CBA from choledochal cyst at diagnostic imaging given the disparate timing and type of surgical treatment necessary for successful management of these distinct entities. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000060PMC
April 2018
8 Reads

Congenital portosystemic shunts: diagnosis and treatment.

Abdom Radiol (NY) 2018 Aug;43(8):2023-2036

Pediatric Surgery Department, Hôpital Bicêtre, Hôpitaux Universitaire Paris-Sud, Assistance Publique Hôpitaux de Paris, Le Kremlin-Bicêtre, France.

Congenital portosystemic shunts (CPSS) are rare vascular malformations that create an abnormal connection between portal and systemic veins resulting in complete or partial diversion of the portal flow away from the liver to the systemic venous system. Different anatomic types exist and several classifications have been proposed. They can be associated with other malformations especially cardiac and heterotaxia. Read More

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http://link.springer.com/10.1007/s00261-018-1619-8
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http://dx.doi.org/10.1007/s00261-018-1619-8DOI Listing
August 2018
28 Reads

Interconversion of elasticity measurements between two-dimensional shear wave elastography and transient elastography.

Med Ultrason 2018 May;20(2):127-133

Department of Radiology and Research Institute of Radiological Science, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.

Aims: To enable comparison and interconversion of elasticity measurements between two-dimensional (2D) shear wave elastography (SWE) and transient elastography (TE).

Materials And Methods: Elasticities of three phantoms were measured by 2D SWE (supersonic shear imaging) using four probes and TE using two probes. We performed regression analyses to evaluate correlation between the measurements and phantom elasticities, and make converting equations. Read More

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http://dx.doi.org/10.11152/mu-1307DOI Listing
May 2018
3 Reads

Resistance index of hepatic artery can predict anastomotic biliary complications after liver transplantation in children.

J Formos Med Assoc 2019 Jan 16;118(1 Pt 2):209-214. Epub 2018 Apr 16.

Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: Biliary complications remain a major morbidity after liver transplantation in children. Inadequate arterial supply to the bile duct after transplantation plays an important role in developing anastomotic biliary complications. We aimed to elucidate the relationship between the resistance index (RI) of hepatic artery and the anastomotic biliary complications after liver transplantation in children. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.03.014DOI Listing
January 2019
19 Reads

Risk Estimation for Biliary Atresia in Patients with Neonatal Cholestasis: Development and Validation of a Risk Score.

Radiology 2018 Jul 10;288(1):262-269. Epub 2018 Apr 10.

From the Department of Radiology and Research Institute of Radiology (J.R.K., H.M.Y., A.Y.J., J.S.L., Y.A.C.), Department of Nuclear Medicine (J.S.K.), Department of Pediatric Surgery (J.M.N., D.Y.K.), and Department of Pediatrics (S.H.O., K.M.K.), Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea; and Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnam-do, South Korea (J.Y.H.).

Purpose To develop and validate a scoring system based on clinical and imaging features to predict the risk for biliary atresia in patients with neonatal cholestasis. Materials and Methods Patients with neonatal cholestasis who underwent both ultrasonography (US) and hepatobiliary scintigraphy (n = 480) were retrospectively identified from two tertiary referral hospitals from January 2000 to February 2017. Patients from one hospital were classified as the derivation cohort (n = 371), and those from the other hospital were classified as the validation cohort (n = 109). Read More

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http://dx.doi.org/10.1148/radiol.2018172390DOI Listing
July 2018
28 Reads

Roux-en-Y enterolith leading to obstruction and ischemic necrosis after pediatric orthotopic liver transplantation.

Pediatr Transplant 2018 05 1;22(3):e13160. Epub 2018 Apr 1.

Department of Surgery, Division of Liver Transplant and HPB Surgery, Rutgers University, Newark, NJ, USA.

Biliary complications are a common cause of morbidity after liver transplantation, with biliary stone formation being a known occurrence generally upstream of a stricture. A 12-year-old boy, who underwent an orthotopic liver transplantation at 11 months of age for biliary atresia, presented acutely with fever and abdominal pain. Cross-sectional imaging revealed Roux-en-Y limb dilatation and thickening. Read More

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http://dx.doi.org/10.1111/petr.13160DOI Listing
May 2018
11 Reads

Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy.

Hepatology 2018 08 24;68(2):616-624. Epub 2018 May 24.

Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.

We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty-eight cholestatic infants (9-87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE was performed during the cholestasis workup, and 15 subjects were diagnosed as BA. Read More

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http://doi.wiley.com/10.1002/hep.29856
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http://dx.doi.org/10.1002/hep.29856DOI Listing
August 2018
15 Reads

MRI-based decision tree model for diagnosis of biliary atresia.

Eur Radiol 2018 Aug 23;28(8):3422-3431. Epub 2018 Feb 23.

Department of Radiology and Research Institute of Radiological Science, Severance Children's Hospital, Yonsei University College of Medicine, 50-1Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.

Objectives: To evaluate MRI findings and to generate a decision tree model for diagnosis of biliary atresia (BA) in infants with jaundice.

Methods: We retrospectively reviewed features of MRI and ultrasonography (US) performed in infants with jaundice between January 2009 and June 2016 under approval of the institutional review board, including the maximum diameter of periportal signal change on MRI (MR triangular cord thickness, MR-TCT) or US (US-TCT), visibility of common bile duct (CBD) and abnormality of gallbladder (GB). Hepatic subcapsular flow was reviewed on Doppler US. Read More

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http://dx.doi.org/10.1007/s00330-018-5327-0DOI Listing
August 2018
5 Reads

Pediatric Living Donor Liver Transplantation Using a Monosegment Procured by Pure 3D Laparoscopic Left Lateral Sectionectomy and In situ Reduction.

J Gastrointest Surg 2018 Jun 12;22(6):1135-1136. Epub 2018 Feb 12.

Department of Surgery, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

Background: Improvements in laparoscopic imaging systems and instruments have increased the performance of pure laparoscopic living donor hepatectomy. This operation is no longer limited to left lateral sectionectomy but is used for left hepatectomy and right hepatectomy.1-5 This report describes a donor who underwent pure laparoscopic left lateral sectionectomy and in situ reduction using 3D laparoscopy and indocyanine green (ICG) near-infrared fluorescence cholangiography to obtain a monosegment. Read More

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http://dx.doi.org/10.1007/s11605-018-3705-1DOI Listing
June 2018
29 Reads
2.800 Impact Factor

[A clinical analysis of children with invasive pulmonary fungal infections after biliary atresia surgery].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Feb;20(2):121-124

Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Objective: To investigate the clinical features of invasive pulmonary fungal infections (IPFIs) after biliary atresia (BA) surgery and related risk factors.

Methods: A retrospective analysis was performed for the clinical data of 49 children with IPFIs after BA surgery, including clinical features, lung imaging findings, and pathogenic features. The risk factors for IPFIs after BA surgery were also analyzed. Read More

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February 2018
2 Reads

Clinical and pathological features of patients with biliary atresia who survived for more than 5 years with native liver.

Pediatr Surg Int 2018 Apr 9;34(4):381-386. Epub 2018 Feb 9.

Surgical Department, Children's Hospital of Fudan University, Shanghai, 201102, China.

Purpose: The objective of this study was to determine the predictive index for prognosis in patients with biliary atresia (BA).

Methods: A total of 71 patients were divided into two groups. Group A included 39 postoperative BA patients who survived for more than 5 years with normal liver function and did not present cirrhosis, and group B included 32 patients who died from liver failure within 1 year after surgery. Read More

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http://dx.doi.org/10.1007/s00383-018-4231-7DOI Listing
April 2018
13 Reads

Laparoscopic cholangiogram in biliary atresia: a refinement in the gallbladder hitch technique.

Pediatr Surg Int 2018 Apr 9;34(4):395-398. Epub 2018 Feb 9.

Christian Medical College and Hospital, Vellore, India.

Introduction: The study describes a refinement in the gallbladder hitch stitch and assesses the value of the laparoscopic cholangiogram in children with suspected biliary atresia.

Methods: Twenty children with neonatal jaundice and no drainage as shown on the HIDA scan underwent a diagnostic laparoscopy through an umbilical 5 mm port. A 3 mm laparoscopic needle holder inserted through a 3. Read More

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http://dx.doi.org/10.1007/s00383-018-4236-2DOI Listing
April 2018
10 Reads
1.060 Impact Factor

Early differential diagnosis methods of biliary atresia: a meta-analysis.

Pediatr Surg Int 2018 Apr 3;34(4):363-380. Epub 2018 Feb 3.

Department of Pediatric Surgery, Tianjin Children's Hospital, Tianjin, 300134, China.

Purpose: To evaluate the accuracy of early differential diagnosis methods of biliary atresia in patients with infantile cholestasis.

Methods: We searched PubMed, EMBASE and the Web of Science databases for articles evaluated the early differential diagnosis methods of biliary atresia. The methodological quality of each study was assessed with version 2 of the Quality Assessment of Diagnostic Accuracy Studies tool. Read More

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http://dx.doi.org/10.1007/s00383-018-4229-1DOI Listing
April 2018
8 Reads

hepatocellular carcinoma after pediatric living donor liver transplantation.

World J Hepatol 2017 Dec;9(36):1361-1366

Division of Digestive Diseases and Transplant and Immunology, Department of Medicine and Surgery, Yale University School of Medicine, New Haven, CT 06510, United States.

malignancies carry an incidence ranging between 3%-26% after transplant and account for the second highest cause of post-transplant mortality behind cardiovascular disease. While the majority of malignancies after transplant usually consist of skin cancers, there has been an increasing rate of solid tumor cancers over the last 15 years. Although, recurrence of hepatocellular carcinoma (HCC) is well understood among patients transplanted for HCC, there are increasing reports of HCC in those transplanted for a non-HCC indication. Read More

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http://dx.doi.org/10.4254/wjh.v9.i36.1361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756726PMC
December 2017
7 Reads

Sarcopenia in Children With End-Stage Liver Disease.

J Pediatr Gastroenterol Nutr 2018 02;66(2):222-226

Division of Gastroenterology, Hepatology and Nutrition.

Background: Sarcopenia, reflected by decreased psoas muscle surface area (PMSA), has been identified as a novel and independent predictor of wait-list mortality and outcomes in adult liver transplantation (LT). We hypothesized that children with end-stage liver disease (ESLD) would have smaller PMSA than healthy controls.

Methods: Computer tomography images of children (ages 0 to 18 years) listed for LT in 2015 and a control group comprised 2:1 age- and gender-matched healthy pediatric trauma victims were reviewed. Read More

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http://dx.doi.org/10.1097/MPG.0000000000001792DOI Listing
February 2018
2 Reads

DYSTROPHIC CALCIFICATION OF MAXILLARY SINUS IN PEDIATRIC PATIENTS WITH LIVER TRANSPLANTATION AND PIGMENTATION OF DENTAL ORGAN.

Rev Paul Pediatr 2018 Jan-Mar;36(1). Epub 2017 Nov 17.

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Objective: To report a case of severe dystrophic calcification in maxillary sinus of a child with liver transplantation and dental organs pigmented by hyperbilirubinemia.

Case Description: female patient, 12 years old, with liver transplantation performed at the age of 7 due to extrahepatic biliary atresia (EHBA). The patient was receiving the immunosuppressant tacrolimus (2 mg daily). Read More

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http://dx.doi.org/10.1590/1984-0462/;2018;36;1;00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849376PMC
October 2018
14 Reads

The value of percutaneous transhepatic treatment of biliary strictures following pediatric liver transplantation.

Radiol Bras 2017 Sep-Oct;50(5):308-313

PhD, Professor, Department of Diagnostic Imaging, Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil.

Objective: To evaluate the percutaneous transhepatic approach to the treatment of biliary strictures in pediatric patients undergoing liver transplantation.

Materials And Methods: This was a retrospective study of data obtained from the medical records, laboratory reports, and imaging examination reports of pediatric liver transplant recipients who underwent percutaneous transhepatic cholangiography, because of clinical suspicion of biliary strictures, between 1st September 2012 and 31 May 2015. Data were collected for 12 patients, 7 of whom were found to have biliary strictures. Read More

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http://dx.doi.org/10.1590/0100-3984.2016.0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656071PMC
November 2017
4 Reads

Early US findings of biliary atresia in infants younger than 30 days.

Eur Radiol 2018 Apr 23;28(4):1771-1777. Epub 2017 Oct 23.

Department of Radiology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, Republic of Korea, 06351.

Purpose: To investigate and compare ultrasound (US) findings for the diagnosis of biliary atresia (BA) in infants younger than 30 days with those of infants older than 30 days.

Materials And Methods: From 2000 to 2015, we reviewed hepatobiliary US images in 12 BA infants younger than 30 days (younger BA group) and 62 BA infants older than 30 days (older BA group) before Kasai procedure. Eight (67%) of younger BA group underwent follow-up US examinations before Kasai procedure. Read More

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http://dx.doi.org/10.1007/s00330-017-5092-5DOI Listing
April 2018
11 Reads

A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy.

Clin Pediatr Endocrinol 2017 28;26(4):251-257. Epub 2017 Sep 28.

Department of Pediatrics, School of Medicine, Shimane University, Shimane, Japan.

Congenital combined pituitary hormone deficiency (CPHD) may present with cholestasis in the neonate or during early infancy. However, its precise mechanism is unknown. A 3-mo-old boy presented with cryptorchidism and hypoplastic scrotum after birth. Read More

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https://www.jstage.jst.go.jp/article/cpe/26/4/26_2017-0014/_
Publisher Site
http://dx.doi.org/10.1297/cpe.26.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627226PMC
September 2017
18 Reads

Percutaneous US-guided Cholecystocholangiography with Microbubbles for Assessment of Infants with US Findings Equivocal for Biliary Atresia and Gallbladder Longer than 1.5 cm: A Pilot Study.

Radiology 2018 03 4;286(3):1033-1039. Epub 2017 Oct 4.

From the Department of Medical Ultrasonics, Institute for Diagnostic and Interventional Ultrasound (L.Y.Z., S.L.C., Y.H., X.Y.X.), Department of Pediatric Surgery (H.D.C.), and Department of Anesthesiology (Y.X.Q.), the First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Rd 2, Guangzhou 510080, P.R. China; and Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou, P.R. China (W.Z.).

Purpose To evaluate the feasibility of ultrasonographically (US) guided percutaneous cholecystocholangiography (PCC) for early exclusion of biliary atresia (BA) in infants suspected of having BA with equivocal US findings or indeterminate type of BA and a gallbladder longer than 1.5 cm at US. Materials and Methods This study was approved by the ethics committee; written informed parental consent was obtained. Read More

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http://dx.doi.org/10.1148/radiol.2017170173DOI Listing
March 2018
12 Reads

50 Years Ago in The Journal of Pediatrics: Diagnosis of Biliary Atresia: Relative Accuracy of Percutaneous Liver Biopsy, Open Liver Biopsy, and Operative Cholangiography.

Authors:
Akihiro Asai

J Pediatr 2017 10;189:188

Division of Gastroenterology, Hepatology, and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.jpeds.2017.04.040DOI Listing
October 2017
1 Read

Usefulness of Tc-DTPA galactosyl human serum albumin liver scintigraphy for evaluating hepatic functional reserve after Kasai procedure.

J Pediatr Surg 2017 Dec 5;52(12):1925-1929. Epub 2017 Sep 5.

Department of Pediatric Surgery, Chiba Children's Hospital, Chiba, Japan.

Background/purpose: We investigated whether Tc-DTPA galactosyl human serum albumin (GSA) liver scintigraphy could help evaluate post-Kasai procedure hepatic functional reserve in order to inform therapeutic strategies, including liver transplantation.

Methods: GSA scintigraphy was performed post-Kasai procedure. Patients were classified as having favorable (native liver survival) or poor (liver transplantation or death) prognoses. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.08.058DOI Listing
December 2017
6 Reads

Liver and systemic hemodynamics in children with cirrhosis: Impact on the surgical management in pediatric living donor liver transplantation.

Liver Transpl 2017 11;23(11):1440-1450

Pediatric Surgery and Transplantation Unit.

Cirrhosis in adults is associated with modifications of systemic and liver hemodynamics, whereas little is known about the pediatric population. The aim of this work was to investigate whether alterations of hepatic and systemic hemodynamics were correlated with cirrhosis severity in children. The impact of hemodynamic findings on surgical management in pediatric living donor liver transplantation (LT) was evaluated. Read More

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http://doi.wiley.com/10.1002/lt.24850
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http://dx.doi.org/10.1002/lt.24850DOI Listing
November 2017
34 Reads

Utility of hepatobiliary scintigraphy in diagnosing or excluding biliary atresia in premature neonates and full-term infants with conjugated hyperbilirubinemia who received parenteral nutrition.

J Matern Fetal Neonatal Med 2018 12 31;31(24):3249-3254. Epub 2017 Aug 31.

e Division of Neonatology , Children's Hospital Los Angeles, Keck School of Medicine of University of Southern California , Los Angeles , CA , USA.

Purpose: Hepatobiliary scintigraphy (HBS) is used to aid in the diagnosis of Biliary Atresia in full-term infants with conjugated hyperbilirubinemia. There is little information on the utility of the HBS in premature infants with conjugated hyperbilirubinemia and infants with parenteral nutrition associated cholestasis (PNAC). The purpose of this study is to assess the utility of HBS in differentiating Biliary Atresia and PNAC in premature neonates and full-term infants who received parenteral nutrition (PN). Read More

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http://dx.doi.org/10.1080/14767058.2017.1368479DOI Listing
December 2018
13 Reads