97,976 results match your criteria Biliary Atresia Imaging


circZMYM2 Competed Endogenously with miR-335-5p to Regulate JMJD2C in Pancreatic Cancer.

Cell Physiol Biochem 2018 7;51(5):2224-2236. Epub 2018 Dec 7.

Departments of Urology, the Third Affiliated Hospital of SooChow University, Changzhou,

Background/aims: We aimed to study the involvement of circZMYM2 (hsa_circ_0099999) in pancreatic cancer (PC) cell proliferation, apoptosis and invasion and to figured out the underlying mechanism of circZMYM2 regulating miR-335-5p and JMJD2C.

Methods: CircRNA differential expressions in twenty PC samples and paired normal tissue samples were analyzed using Arraystar Human CircRNA microarray V1. CircZMYM2 expression level was determined via qRT-PCR. Read More

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December 2018

Portal vein embolization DOES not AFFECT the long-term survival and risk of cancer recurrence among colorectal liver metastases patients: A prospective cohort study.

Int J Surg 2018 Dec 8. Epub 2018 Dec 8.

Service de chirurgie hépatobiliaire et pancréatique et de transplantation, Département de chirurgie, Centre Hospitalier de l'Université de Montréal, Site St-Luc, Montréal, QC, Canada.

Background: Previous studies comparing the survival outcomes of liver resections with and without preoperative portal vein embolization (PVE) for colorectal liver metastases (CLM) have linked PVE to higher rate of tumor progression, lower overall survival (OS) and lower disease-free survival (DFS). The lack of adjusted models to compare these outcomes is a limitation of these studies since patients requiring PVE may differ significantly from the ones receiving upfront surgery.

Materials And Methods: Prospective cohort study of 128 patients undergoing CLM resection. Read More

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December 2018

Adjuvant Therapy for Biliary Tract Cancers.

J Oncol Pract 2018 Dec;14(12):701-708

South East Cancer Center, University Hospital Waterford, Waterford, Ireland; and Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

Biliary tract cancers, including gallbladder cancer, intrahepatic, perihilar, and distal cholangiocarcinomas, although anatomically contiguous, represent a heterogeneous group of cancers with extensive biologic and genetic diversity. With early disease, surgical resection is the preferred option for all subtypes; however, relapse rates remain high, and survival outcomes are poor. Data to guide the use of adjuvant therapy have been limited to retrospective series, population-based studies, and meta-analyses, all with their associated limitations. Read More

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December 2018

Adjuvant Therapy for Biliary Tract Cancers: Desperately Seeking Data.

J Oncol Pract 2018 Dec;14(12):719-720

Center for Innovations in Quality, Effectiveness, and Safety at the Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX.

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December 2018

Adjuvant Therapy for Biliary Tract Cancers: New Evidence to Resolve Old Questions.

J Oncol Pract 2018 Dec;14(12):723-724

The Ohio State University Wexner Medical Center, Columbus, OH.

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December 2018

Validation of the albumin-indocyanine green evaluation model in patients with resected hepatocellular carcinoma and comparison with the albumin-bilirubin score.

J Hepatobiliary Pancreat Sci 2018 Dec 8. Epub 2018 Dec 8.

Department of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy.

Background: The albumin-indocyanine green evaluation (ALICE) model based on serum albumin and indocyanine retention rate, has been shown to be an effective method for predicting postoperative outcomes in hepatocellular carcinoma patients. Aim of the study was to validate the ALICE model in a large Western cohort of patients by comparing the Albumin-Bilirubin (ALBI) score and Child-Turcotte-Pugh (CTP) score.

Methods: A total of 400 patients who underwent hepatic resection from 01/2005 to 06/2016 at 3 centers were enrolled. Read More

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December 2018

Mouse Model for Cholangiocarcinoma from Peribiliary Glands.

Methods Mol Biol 2019 ;1905:237-245

Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.

A good mouse model is mandatory for elucidating carcinogenic mechanisms and identifying the cellular origin of cancer. Although the lack of an appropriate mouse model has hampered investigation of extrahepatic cholangiocarcinoma (ECC), we recently established a novel mouse model of biliary injury-related ECC by ductal cell-specific activation of Kras and deletion of transforming growth factor (TGF) β receptor type 2 and E-cadherin. Using this mouse model, we identified that peribiliary glands, which are considered a biliary epithelial stem cell niche, are potential cellular origins of ECC. Read More

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January 2019

Analysis for Remodeling of Hepatic Tissue Structures in 3D During Regeneration.

Authors:
Kota Kaneko

Methods Mol Biol 2019 ;1905:187-198

Department of Pathology, School of Medicine, University of California, San Diego, CA, USA.

It has been demonstrated that the liver remarkably alter its tissue structures during regeneration, and various types of liver stem or progenitor cells locating in specific areas in the liver tissue contribute to regeneration. Therefore, it is important to analyze the dynamic rearrangement of the liver tissue structures in 3D for better understanding the process and mechanism of liver regeneration. Here we describe a macroscopic analysis method to visualize the whole 3D structure of the vasculatures and the biliary tree, which are dynamically remodeled during regeneration, and a microscopic analysis method to visualize detailed structures at the cellular level, which can compensate what cannot be detected in the macroscopic analysis. Read More

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January 2019

Generation of Hepatic Organoids with Biliary Structures.

Methods Mol Biol 2019 ;1905:175-185

Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.

Incorporation of bile drainage system into engineered liver tissue is an important issue to advance liver regenerative medicine. Our group reported that three-dimensional (3D) coculture of fetal liver cells (FLCs) and adult rat biliary epithelial cells (BECs) allows reconstruction of hepatic spheroids that possess bile ductular structures. In this chapter, we describe the detailed protocol to isolate FLCs and BECs and to generate the spheroids with bile drainage system using these two types of primary cells. Read More

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January 2019

Chemically Induced Liver Progenitors (CLiPs): A Novel Cell Source for Hepatocytes and Biliary Epithelial Cells.

Methods Mol Biol 2019 ;1905:117-130

Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.

Bipotent liver progenitor cells (LPCs) are promising cell sources for cell transplantation therapy in hepatic disorders as well as biliary dysfunctions. Using a cocktail of small molecules, we recently reported a novel approach to generate bipotent LPCs, named chemically induced liver progenitors (CLiPs), from adult rat hepatocytes. In this chapter, we describe a detailed protocol for the induction of rat CLiPs. Read More

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January 2019

Chemical Screening Using a Zebrafish Model for Liver Progenitor Cell-Driven Liver Regeneration.

Methods Mol Biol 2019 ;1905:83-90

Department of Developmental Biology, McGowan Institute for Regenerative Medicine, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.

Following massive hepatocyte ablation in zebrafish, biliary epithelial cells can extensively give rise to hepatocytes through liver progenitor cells (LPCs). The zebrafish liver injury model is an important system to elucidate the molecular mechanisms underlying LPC-driven liver regeneration. Here, we describe a chemical screening method using the zebrafish model for identifying small molecules that can modulate LPC-driven liver regeneration. Read More

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January 2019

Genetic Lineage Tracing of Biliary Epithelial Cells.

Methods Mol Biol 2019 ;1905:45-57

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Lineage tracing of liver cells is a powerful tool to understand liver embryonic development, healthy liver cell homeostasis, tissue repair, and regeneration. Lineage tracing of biliary epithelial cells (BECs) in the adult liver has been used to assess the contribution of the biliary epithelium to liver injury, regeneration, and disease. These studies have shown the contribution of BECs to the expansion of ductular reaction (DR) and liver progenitor cells (LPCs) and eventually the generation of new hepatocytes. Read More

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January 2019

The impact of empiric endoscopic biliary sphincterotomy on future gallstone-related complications in patients with non-severe acute biliary pancreatitis whose cholecystectomy was deferred or not performed.

Surg Endosc 2018 Dec 7. Epub 2018 Dec 7.

Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: Early cholecystectomy (EC) is recommended in patients with acute biliary pancreatitis (ABP). In real-life practice, cholecystectomy is frequently deferred due to various reasons and delayed cholecystectomy (DC) is performed instead. Endoscopic sphincterotomy (ES) is an alternative to prevent recurrent pancreatitis, however other gallstone-related complications (GCs) may still develop. Read More

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December 2018

A Comparative Study of Single and Dual Perfusion During End-ischemic Subnormothermic Liver Machine Preservation.

Transplant Direct 2018 Nov 23;4(11):e400. Epub 2018 Oct 23.

Division of Organ Transplantation, Department of Surgery, UMass Memorial Medical Center, University of Massachusetts, Worcester, MA.

Background: It remains controversial if arterial perfusion in addition to portal vein perfusion during machine preservation improves liver graft quality. Comparative studies using both techniques are lacking. We studied the impact of using single or dual machine perfusion of donation after circulatory death rat livers. Read More

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November 2018

A Rare Case of Pylephlebitis as a Complication of Cholecystocolonic Fistula.

Case Rep Surg 2018 4;2018:3931674. Epub 2018 Nov 4.

Department of Surgery, Chugoku Rosai Hospital, 1-5-1 Hirotagaya, Kure, Hiroshima 737-0193, Japan.

Pylephlebitis is defined as a septic thrombophlebitis of the portal vein and its tributaries that is associated with multiple suppurative abdominal infections. We report a case of pylephlebitis associated with a cholecystocolonic fistula (CCF). A 41-year-old man presented with upper abdominal pain and anorexia for 1 month. Read More

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November 2018

[Comparative analysis of side-by-side antegrade stenting and Y-biliary stenting for malignant biliary stricture].

Khirurgiia (Mosk) 2018 (11):20-23

Botkin Municipal Clinical Hospital, Moscow, Russia.

In the time period from 2009 to 2017 in Botkin Hospital (Moscow) bilateral biliary stenting was performed in 43 patients with malignant common hepatic duct stricture. Patients were divided into 2 statistically homogeneous groups: 'side-by-side' stenting in 28 patients and percutaneous 'Y'-biliary stent placement in 15 patients. The causes of malignant obstruction were as follows: in the 1 group 13 (46. Read More

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January 2018

[Malignant obstructive jaundice management via external biliary drainage followed by bile examination].

Khirurgiia (Mosk) 2018 (10):44-50

South Ural State Medical University of Healthcare Ministry of the Russian Federation, Chelyabinsk, Russia.

Aim: To determine optimal terms of biliary decompression and bile reinfusion into gastrointestinal tract in patients with malignant obstructive jaundice.

Material And Methods: 179 medical records of patients with obstructive jaundice were analyzed to identify risk factors of postoperative complications. Prospective research included bile examination in 34 patients with malignant obstructive jaundice. Read More

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January 2018

[Predictors of outcomes in surgery for hilar cholangiocarcinoma].

Khirurgiia (Mosk) 2018 (10):5-11

Vishnevsky National Medical Research Center of Surgery of Healthcare Ministry of Russia, Moscow, Russia.

Aim: To determine significant predictors of long-term outcomes of surgery for portal cholangiocarcinoma.

Material And Methods: Analysis included 49 out of 84 patients who were operated at the Vishnevsky Institute of Surgery in 2003-2016. Morphological examination (2011-2016) revealed great percentage of following positive variables: micro- (42. Read More

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January 2018

Percutaneous Treatment of Biliary Strictures After Pediatric Liver Transplantation.

Ann Transplant 2018 Dec 11;23:845-851. Epub 2018 Dec 11.

Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.

BACKGROUND Biliary strictures (BS) are frequent after pediatric liver transplantation (LTx) and in spite of ongoing progress, they remain a significant cause of morbidity. In children, the majority of reconstruction is hepatico-jejunal anastomosis (HJA). The aim of this study was to analyze our experience in percutaneous transhepatic treatment of BS. Read More

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December 2018

EUS-guided antegrade metal stenting with hepaticoenterostomy using a dedicated plastic stent with a review of the literature (with video).

Endosc Ultrasound 2018 Nov-Dec;7(6):404-412

Third Department of Surgery, Tokyo Medical University, Tokyo, Japan.

Background And Objectives: Recently, a novel EUS-guided biliary drainage (EUS-BD) technique consisting of EUS-guided antegrade stenting and EUS-guided hepaticoenterostomy (EUS-AS+HES) using two conventional metal stents (MS) has been reported to decrease adverse events and maintain longer stent patency for malignant biliary obstruction (MBO). However, only a few limited reports have evaluated this technique. Finally, dedicated plastic stents (PSs) have been developed to perform EUS-HES safely. Read More

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December 2018

A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells.

Cell Signal 2018 Dec 7. Epub 2018 Dec 7.

Department of Otolaryngology, Emory University, Atlanta, GA, USA. Electronic address:

During craniofacial development, cranial neural crest (CNC) cells migrate into the developing face and form bone through intramembranous ossification. Loss of JAGGED1 (JAG1) signaling in the CNC cells is associated with maxillary hypoplasia or maxillary bone deficiency (MBD) in mice and recapitulates the MBD seen in humans with Alagille syndrome. JAGGED1, a membrane-bound NOTCH ligand, is required for normal craniofacial development, and Jagged1 mutations in humans are known to cause Alagille Syndrome, which is associated with cardiac, biliary, and bone phenotypes and these children experience increased bony fractures. Read More

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December 2018

Health-related quality of life in pre-adolescent liver transplant recipients with biliary atresia: A cross-sectional study.

Clin Res Hepatol Gastroenterol 2018 Dec 6. Epub 2018 Dec 6.

Transplant and regenerative medicine centre, division of pediatric gastroenterology, hepatology and nutrition, the hospital for sick children, university of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: Pediatric recipients of liver transplantation (LT) often report lower Health-Related Quality of Life (HRQOL) than healthy controls when assessed on generic HRQOL measurement tools. The recent addition of the Pediatric Liver Transplant Quality of Life (PeLTQL), a novel disease-specific HRQOL instrument for pediatric LT recipients, into the clinical armamentarium of tools now routinely available to clinical care teams, provides the unique opportunity to identify disease-related challenges in children who have undergone this life-saving intervention. This study assesses HRQOL in pre-adolescent aged patients with a primary diagnosis of biliary atresia (BA) who underwent LT as an infant, using both generic and disease-specific HRQOL instruments validated for children. Read More

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December 2018

Effect of critical care complications on perioperative mortality and hospital length of stay after hepatectomy: A multicenter analysis of 21,443 patients.

Am J Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgery - Transplant Division, University of Kentucky, College of Medicine, Lexington, KY, 40536, USA. Electronic address:

Objective: To determine predictors of critical care complications (CCC) in patients undergoing hepatectomy.

Methods: All hepatectomy patients in NSQIP from 2012 to 2016 were analyzed. CCC included prolonged ventilation (>48 h), sepsis/septic shock, renal failure/insufficiency, cardiac arrest/AMI and pulmonary embolism. Read More

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November 2018

NFKB1 and MANBA confer disease-susceptibility to primary biliary cholangitis via independent putative primary functional variants.

Cell Mol Gastroenterol Hepatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Human Genetics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.

Background & Aims: Primary biliary cholangitis (PBC) is a chronic and cholestatic liver disease that eventually leads to liver cirrhosis and hepatic failure. We recently identified several susceptibility genes included the nuclear factor kappa B subunit 1 (NFKB1) and mannosidase beta (MANBA) for PBC in the Japanese population by genome-wide association study (GWAS). However, the primary functional variants in the NFKB1/MANBA region and the molecular mechanism for conferring disease susceptibility to PBC have not yet been clarified. Read More

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December 2018

Effect of Hyperbilirubinemia on Hepatic Hypertrophy after Portal Vein Embolization and Liver Failure after Heatectomy in Primary Biliary Malignancy.

J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Kyungpook National University School of Medicine, Daegu, Korea.

Purpose: To retrospectively investigate the impact of hyperbilirubinemia on future liver remnant (FLR) volume after percutaneous transhepatic portal vein embolization (PVE) and incidence of post-hepatectomy liver failure in primary biliary malignancy.

Materials And Methods: Eighty-seven patients (62 men, overall mean age 66.9 y) who underwent PVE, using Gelfoam and coils before major hepatectomy between January 2004 and June 2016, were included in this study and divided into a hyperbilirubinemia (serum total bilirubin level at PVE 5. Read More

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December 2018

Management of asymptomatic, well-differentiated PNETs: results of the Delphi consensus process of the Americas Hepato-Pancreato-Biliary Association.

HPB (Oxford) 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, USA.

Background: Variation in the management of PNETs exist due to the limited high-level evidence to guide clinical practice. The aim of this work is to generate consensus guidelines with a Delphi process for managing PNETs.

Methods: A panel of experts reviewed the surgical literature and scored a set of clinical case statements using a web-based survey to identify areas of agreement and disagreement. Read More

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December 2018

Comparison of Laparoscopic and Open Approach in Treating Gallbladder Cancer.

J Surg Res 2019 Feb 16;234:269-276. Epub 2018 Oct 16.

Changzhou First People's Hospital, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China. Electronic address:

Background: Preliminary study on the feasibility and efficacy of laparoscopic cholecystectomy and radical cholecystectomy in stage Tis-T3 gallbladder cancer (GBC).

Methods: Retrospective analysis of the clinical data of 102 patients with GBC from August 2008 to August 2017 in the Department of Hepatopancreatobiliary Surgery at the Third Affiliated Hospital of Soochow University. The clinical and pathological data of laparoscopic surgery and open surgery were compared. Read More

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February 2019
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A 44-Year-Old Woman With Sudden Breathlessness, Tightness in Chest, and Hypotension After Extubation in the Early Postoperative Period After Liver Transplantation.

Chest 2018 Dec;154(6):e177-e180

Critical Care Medicine Department, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubiran, Mexico City, Mexico. Electronic address:

Case Presentation: A 44-year-old woman with Child-Pugh class C cirrhosis due to primary biliary cirrhosis and mild portopulmonary syndrome received a liver transplant. Her basal catheterization showed a mean pulmonary arterial pressure (mPAP) of 28 mm Hg, pulmonary artery occlusion pressure (PAOP) of 8 mm Hg, pulmonary vascular resistance (PVR) of 307 dynes.s. Read More

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December 2018

Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer.

Cancer Imaging 2018 Dec 10;18(1):49. Epub 2018 Dec 10.

Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang Province, China.

Background: Pancreatic adenocarcinoma is often diagnosed at an advanced stage when adjacent vascular invasion is present. Accurate evaluation of presence of vascular invasion can help guide therapy. The aim of this study was to construct a nomogram for preoperative prediction of peripancreatic vein invasion in patients with pancreatic head cancer. Read More

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December 2018

Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern may be Characterized by ARID1A Genetic Alterations.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa.

Cholangiolocellular carcinoma (CLC) is a unique subtype of primary liver carcinoma, which sometimes coexists with hepatocellular carcinoma (HCC), cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma (cHCC-CCA). "Ductal plate malformation" (DPM)-pattern of primary liver carcinoma, which resembles biliary lesions in Caroli disease and von Meyenburg complex, is sometimes associated with CLC. We examined genetic alterations of hTERT promoter (hTERT), IDH1 or 2 (IDH1/2), KRAS, ARID1A, PBRM1, ARID2, BAP1, p53 and their association with histologic features such as proportion of CLC and DPM-pattern in 77 patients with primary liver carcinoma diagnosed as cHCC-CCA or CLC. Read More

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December 2018
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Index Admission Emergency Laparoscopic Cholecystectomy and Common Bile Duct Exploration: Results From a Specialist Center in the United Kingdom.

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery, Royal Derby Hospital, Uttoxeter Road, Derby, UK.

Background: The incidence of common bile duct (CBD) stones is between 10% to 18% in people undergoing cholecystectomy for gallstones. Laparoscopic exploration of the CBD is now becoming routine practice in the elective setting, however its safety and efficacy in emergencies is poorly understood.

Methods: We analyzed our results for index emergency admission laparoscopic cholecystectomy within a specialist center in the United Kingdom. Read More

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December 2018

Accuracy of Right Upper Quadrant Ultrasound in Estimating Gallbladder Wall Thickness.

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Departments of Surgery.

Objective: Ultrasound (US) evaluation of biliary pathology can be influenced by a variety of factors. This study examines the effect of patient specific factors on the accuracy of sonographic evaluation of gallbladder wall thickness (GBW).

Methods: We performed a retrospective review of all patients who underwent cholecystectomy at a single institution from November 2012 to October 2015. Read More

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December 2018
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Proteomic Landscape of Cholangiocarcinomas Reveals 3 Different Subgroups According to their Localization and the Aspect of Non-Tumor Liver.

Proteomics Clin Appl 2018 Dec 6:e1800128. Epub 2018 Dec 6.

UMR 1149 INSERM - Paris Diderot University, Inflammation Research Center, Paris, France.

Purpose: Cholangiocarcinomas (CC), tumors derived from epithelial biliary cells, define a heterogeneous entity based upon their anatomic localization (intra- versus extrahepatic) and, for those developing in the liver, depending on the aspect of non-tumor liver (normal versus cirrhosis). The aim of the study was to characterize the molecular heterogeneity of the different types of CC by a global proteomic approach.

Experimental Design: Thirty-three tumor samples from 17 intrahepatic CC (iCC) including 9 and 8 developed on normal (iCC ) and cirrhotic liver (iCC ), respectively; 5 hilar CC (CC ), 5 CC developed in the pancreatic portion of the bile duct (CC ) and 6 hepatocellular carcinoma (HCC), were submitted to label-free quantitative proteomic analysis. Read More

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December 2018

Growth of children with biliary atresia living with native livers: impact of corticoid therapy after portoenterostomy.

Eur J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

Pediatric Liver and Gut Research Group, Children's Hospital, Helsinki University Hospital, Helsinki, Finland.

We addressed growth of biliary atresia (BA) patients living with native livers between ages 0-6 and effects of post-surgical corticosteroid treatment on growth. Growth charts of 28 BA patients born in Finland between 1987 and 2017 were retrospectively evaluated. Dosage and length of corticosteroid treatment and hydrocortisone substitution were reviewed. Read More

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December 2018

A case of duodenal hemorrhage due to arteriovenous malformation around a serous cystic neoplasm.

Surg Case Rep 2018 Dec 5;4(1):140. Epub 2018 Dec 5.

Department of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, 1007, Shimo-Nagakubo, Sunto-Nagaizumi, Shizuoka, 4118777, Japan.

Background: No reports have so far described arteriovenous malformation (AVM) in the pancreas caused by a tumor. We herein report a case of pancreatoduodenectomy for a patient who developed duodenal hemorrhage due to AVM developed around serous cystic neoplasm (SCN) of the pancreas.

Case Presentation: A 79-year-old man was referred to our hospital because of anemia (Hb 7. Read More

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December 2018
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CT imaging comparison between intraductal papillary neoplasms of the bile duct and papillary cholangiocarcinomas.

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.

Objectives: To identify imaging features that assist in discriminating intraductal papillary neoplasms of the bile duct (IPNBs) from papillary cholangiocarcinomas (PCCs).

Methods: This study was approved by the institutional review board. Using the recently proposed histological diagnostic criteria for biliary papillary neoplasms, IPNBs and PCCs were selected from 537 biliary neoplasms consecutively resected in a 12. Read More

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December 2018
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Overexpression of RALY promotes migration and predicts poor prognosis in hepatocellular carcinoma.

Cancer Manag Res 2018 9;10:5559-5572. Epub 2018 Nov 9.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong, China,

Introduction: RALY plays a critical role in promoting invasiveness and is associated with poor prognosis in different types of cancers. However, the prognostic value of RALY and its precise role in hepatocellular carcinoma (HCC) remain unknown.

Materials And Methods: We detected the expression of RALY in 127 clinical HCC tissue samples and seven HCC cell lines by immunohistochemical staining and Western blotting. Read More

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November 2018

Five-year native liver survival analysis in biliary atresia from a single large Chinese center: The death/liver transplantation hazard change and the importance of rapid early clearance of jaundice.

J Pediatr Surg 2018 Oct 30. Epub 2018 Oct 30.

General Surgery Department of Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, 56# Nanlishi Road, Beijing, China. Electronic address:

Purpose: This study aimed to analyze the change of death/liver transplantation hazard and biochemical indexes over time after Kasai procedure (KP) based on a retrospective biliary atresia (BA) cohort, and to evaluate the predictive value of early jaundice clearance rate to 5-year native liver survival (NLS).

Methods: A retrospective cohort with follow-up results of 139 BA patients from January 2009 to December 2012 was established, and the pre- and postoperative data were collected. NLS rates were estimated with Kaplan-Meier curves, and any differences between groups were tested by log-rank test. Read More

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October 2018

Comparison of efficacy and safety of transpancreatic septotomy, needle-knife fistulotomy or both based on biliary cannulation unintentional pancreatic access and papillary morphology.

Hepatobiliary Pancreat Dis Int 2018 Nov 24. Epub 2018 Nov 24.

Digestive Endoscopy Center, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: Precut sphincterotomy has been widely performed to facilitate selective biliary access when standard cannulation attempts failed during endoscopic retrograde cholangiopancreatography (ERCP). However, scarce data are available on different precut techniques for difficult biliary cannulation. This study aimed to evaluate the efficacy and safety of transpancreatic septotomy (TPS), needle-knife fistulotomy (NKF) or both based on the presence of unintentional pancreatic access and papillary morphology. Read More

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November 2018
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Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

School of Medicine and Surgery, University of Milan-Bicocca, Via Cadore 48, 20900 Monza, Italy.

The cholangipathies are a class of liver diseases that specifically affects the biliary tree. These pathologies may have different etiologies (genetic, autoimmune, viral, or toxic) but all of them are characterized by a stark inflammatory infiltrate, increasing overtime, accompanied by an excess of periportal fibrosis. The cellular types that mount the regenerative/reparative hepatic response to the damage belong to different lineages, including cholagiocytes, mesenchymal and inflammatory cells, which dynamically interact with each other, exchanging different signals acting in autocrine and paracrine fashion. Read More

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December 2018
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Role of Image-Enhanced Endoscopy in Pancreatobiliary Diseases.

Clin Endosc 2018 Nov 30;51(6):541-546. Epub 2018 Nov 30.

Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.

Recent advances in cholangiopancreatoscopy technology permit image-enhanced endoscopy (IEE) for pancreatobiliary diseases. There are limitations in endoscopy performance and in the study of the clinical role of IEE in bile duct or pancreatic duct diseases. However, currently available IEEs during cholangiopancreatoscopy including traditional dye-aided chromoendoscopy, autofluorescence imaging, narrow-band imaging, and i-Scan have been evaluated and reported previously. Read More

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November 2018
2 Reads

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

PLoS Genet 2018 Dec 3;14(12):e1007833. Epub 2018 Dec 3.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, but at least three additional independent HLA haplotypes contribute to susceptibility. We used dense single nucleotide polymorphism (SNP) data in 2861 PBC cases and 8514 controls to impute classical HLA alleles and amino acid polymorphisms using state of the art methodologies. Read More

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December 2018

Augmented Reality to Improve Surgical Simulation. Lessons Learned Towards the Design of a Hybrid Laparoscopic Simulator for Cholecystectomy.

IEEE Trans Biomed Eng 2018 Nov 28. Epub 2018 Nov 28.

Hybrid surgical simulators based on Augmented Reality (AR) solutions benefit from the advantages of both the box trainers and the Virtual Reality simulators. This paper reports on the results of a long development stage of a hybrid simulator for laparoscopic cholecystectomy that integrates real and the virtual components. We first outline the specifications of the AR simulator and then we explain the strategy adopted for implementing it based on a careful selection of its simulated anatomical components, and characterized by a real-time tracking of both a target anatomy and of the laparoscope. Read More

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November 2018
1 Read