795 results match your criteria Biliary Atresia Imaging


Novel approach for the diagnosis of occult cytomegalovirus cholangitis after pediatric liver transplantation: A case report.

World J Clin Cases 2020 Jun;8(12):2597-2602

Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Background: Cytomegalovirus (CMV) infection is a common infection in liver transplant recipients, which is related to chronic rejection and biliary complications. It is often diagnosed based on serum CMV-DNA or CMV pp65. To our knowledge, this is the first report of the successful treatment of occult CMV cholangitis in a pediatric liver transplantation (LT) recipient. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322438PMC

Periportal thickening on magnetic resonance imaging for hepatic fibrosis in infantile cholestasis.

World J Gastroenterol 2020 Jun;26(21):2821-2830

Department of Radiology, Severance Hospital, Severance Pediatric Liver Disease Research Group, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 03722, South Korea.

Background: Untreated neonatal cholestasis can progress to liver cirrhosis and end stage liver disease in infancy due to prolonged hepatocyte and biliary tree injury and may require liver transplantation. Therefore, non-invasive evaluation of hepatic fibrosis is important in infants with cholestasis.

Aim: To investigate the usefulness of periportal thickening (PT) measured on liver magnetic resonance imaging (MRI) for the assessment of hepatic fibrosis in infants with cholestasis including biliary atresia (BA). Read More

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http://dx.doi.org/10.3748/wjg.v26.i21.2821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284183PMC

Urgent cholecystectomy in patient with left-sided gallbladder Case report and review of the literature.

Ann Ital Chir 2020 May 25;9. Epub 2020 May 25.

Introduction: Sinistroposition of the gallbladder, or true left-sided gallbladder (LSG) without situs viscerum inversus, is a rare congenital anatomical variant where the gallbladder is located to the left of round/falciform ligament. It can be associated with anomalies of the biliary tree, portal system and hepatic vascularization. The surgical management of a LSG could be challenging even for an experienced operator, being usually an incidental intraoperative finding. Read More

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Torsion of an Accessory Spleen in a Child With Biliary Atresia Splenic Malformation Syndrome.

Front Pediatr 2020 4;8:220. Epub 2020 May 4.

Department of Gastroenterology and Hepatology, Children's Mercy Hospitals and Clinics, Kansas City, MO, United States.

Torsion of an accessory spleen is an exceedingly rare cause of abdominal pain in pediatric patients. The diagnosis is frequently challenging as presentation is variable and diagnostic imaging can be aspecific. The current case describes an unusual presentation of a torted accessory spleen in a 5-year-old girl with biliary atresia splenic malformation syndrome who initially presented with non-specific abdominal symptoms and fever. Read More

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http://dx.doi.org/10.3389/fped.2020.00220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212802PMC

Validating the BAVENO VI criteria to identify low risk biliary atresia patients without endoscopy for esophageal varix.

Clin Res Hepatol Gastroenterol 2020 May 13. Epub 2020 May 13.

Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Severance Pediatric Liver Disease Research Group, Seoul, Republic of Korea. Electronic address:

Background And Aims: Portoenterostomy is the initial surgical treatment for biliary atresia (BA); however, no curative therapy exists for BA. Varix bleeding is a major complication of end-stage liver disease and must be determined in patients with BA, necessitating routine surveillance using esophagogastroduodenoscopy (EGD). We attempted to validate criteria to identify BA patients requiring EGD. Read More

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http://dx.doi.org/10.1016/j.clinre.2020.04.007DOI Listing

Embolization of congenital portosystemic shunt presenting after pediatric liver transplantation: Case report and literature review.

Pediatr Transplant 2020 May 14:e13713. Epub 2020 May 14.

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

This case report describes a 13-year 10-month-old girl who underwent a deceased-donor split LT for primary diagnosis of biliary atresia at the age of 12 months, who presented with a lower GI bleed. Ultrasound and CT revealed a venous vascular anomaly involving the cecum and ascending colon, with communication of the SMV and pelvic veins consistent with a CEPS. Associated varices were noted in the pelvis along the uterus and urinary bladder. Read More

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http://dx.doi.org/10.1111/petr.13713DOI Listing

Three-color risk stratification for improving the diagnostic accuracy for biliary atresia.

Eur Radiol 2020 Jul 11;30(7):3852-3861. Epub 2020 Mar 11.

Department of Neonatology, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.

Objectives: It is challenging to early differentiate biliary atresia from other causes of cholestasis. We aimed to develop an algorithm with risk stratification to distinguish biliary atresia from infantile cholestasis.

Methods: In this study, we enrolled infants with cholestasis into 2 subgroups from January 2010 to April 2019. Read More

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http://dx.doi.org/10.1007/s00330-020-06751-7DOI Listing

Fetal Hepatomegaly: Causes and Associations.

Radiographics 2020 Mar-Apr;40(2):589-604

From the Department of Diagnostic Radiology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, L-340, Portland, OR 97239.

Fetal hepatomegaly is associated with significant fetal morbidity and mortality. However, hepatomegaly might be overlooked when numerous other fetal anomalies are present, or it might not be noticed when it is an isolated entity. As the largest solid organ in the abdomen, the liver can be seen well with US or MRI, and the normal imaging characteristics are well described. Read More

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http://dx.doi.org/10.1148/rg.2020190114DOI Listing

Hepatic subcapsular or capsular flow in biliary atresia: is it useful imaging feature after the Kasai operation?

Eur Radiol 2020 Jun 11;30(6):3161-3167. Epub 2020 Feb 11.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, South Korea.

Objectives: To evaluate the implications of hepatic subcapsular and capsular flows using ultrasonography (US) in children after Kasai operation.

Methods: Children who underwent liver US including color Doppler US and microvascular imaging (MVI) from May 2017 to October 2017 were retrospectively included. Children who underwent the Kasai operation for biliary atresia were included in the Kasai group and children with normal liver were included in the control group. Read More

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http://dx.doi.org/10.1007/s00330-020-06656-5DOI Listing
June 2020
4.014 Impact Factor

A novel timesaving and semiquantitative method for radionuclide hepatobiliary scintigraphy for suspected biliary atresia.

Ann Palliat Med 2020 Jan;9(1):63-69

Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Background: To optimize the performance of the hepatobiliary scintigraphy (HS) for suspected biliary atresia (BA) using a timesaving and semiquantitative method without a loss in diagnostic accuracy.

Methods: A retrospective analysis of 185 patients with persistent jaundice who underwent surgery were included. According to the surgical evaluation and pathological diagnosis, patients were divided into a BA group (99 cases) and an infant hepatitis syndrome (IHS) group (86 cases). Read More

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http://dx.doi.org/10.21037/apm.2019.12.07DOI Listing
January 2020

Assessing Liver Hemodynamics in Children With Cholestatic Cirrhosis by Use of Dual-Energy Spectral CT.

AJR Am J Roentgenol 2020 03 22;214(3):665-670. Epub 2020 Jan 22.

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, 95 Yong'an Rd, Xicheng District, Beijing, China, 100050.

The purpose of this study was to evaluate the value of dual-energy CT (DECT) in assessing liver hemodynamics in children with cholestatic cirrhosis. The cases of 60 children with cholestatic cirrhosis (study group) and 15 children with inherited metabolic diseases but normal liver function (control group) were retrospectively evaluated. Enhanced CT scans were obtained in spectral imaging mode. Read More

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http://dx.doi.org/10.2214/AJR.19.22035DOI Listing

Clinical utility of mono-exponential model diffusion weighted imaging using two b-values compared to the bi- or stretched exponential model for the diagnosis of biliary atresia in infant liver MRI.

PLoS One 2019 18;14(12):e0226627. Epub 2019 Dec 18.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.

Purpose: To investigate the clinical utility of mono-exponential model diffusion weighted imaging (DWI) using two b-values compared to the bi- or stretched exponential model to differentiate biliary atresia (BA) from non-BA in pediatric liver magnetic resonance imaging (MRI).

Methods: Patients who underwent liver MRI with DWI for suspected BA from November 2017 to September 2018 were retrospectively included and divided into BA and non-BA groups. Laboratory results including γ-glutamyl transferase (γGT) were compared between the two groups using the Mann-Whitney U test and Fisher's exact test. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226627PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920030PMC

Left atrial isomerism associated with aneurysmal enlargement of right atrial appendage: A case report with literature review.

Indian J Radiol Imaging 2019 Jul-Sep;29(3):318-323. Epub 2019 Oct 30.

Department of Ultrasound, Meera Hospital, Shiv Marg, Bani Park, Jaipur, Rajasthan, India.

We present a prenatally diagnosed case of heterotaxy syndrome (HS) in which left atrial isomerism (LAI) was associated with an aneurysmal enlargement of the right atrial appendage (RAA). Although LAI is usually associated with complex cardiac and extracardiac anomalies, the association of LAI and right atrial appendage aneurysm (RAAA) is exceptional. Congenital RAAA itself is an idiopathic, very rare cardiac anomaly characterized by the enlargement of the appendage in the absence of any other cardiac or extra-cardiac defect. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_341_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857260PMC
October 2019

False-negative Hepatobiliary Scintigraphy for Biliary Atresia.

Nucl Med Mol Imaging 2019 Oct 21;53(5):356-360. Epub 2019 Aug 21.

1Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

We present the case of a patient with biliary and duodenal atresia who showed false-negative hepatobiliary scintigraphy results. The patient was born at 37 weeks and 2 days of gestation. Her mother had undergone amnioreduction after detection of a double-bubble ultrasound sign in the fetal abdomen. Read More

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http://dx.doi.org/10.1007/s13139-019-00606-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821929PMC
October 2019

Expanding the phenotype in Adams-Oliver syndrome correlating with the genotype.

Am J Med Genet A 2020 01 25;182(1):29-37. Epub 2019 Oct 25.

AP-HP, Service de Génétique Clinique, Necker-Enfants malades University Hospital, Paris, France.

Rationale: Adams-Oliver syndrome (AOS) is a genetic disorder characterized by the association of aplasia cutis congenita (ACC), terminal transverse limb defect (TTLD), congenital cardiac malformation (CCM), and minor features, such as cutaneous, neurological, and hepatic abnormalities (HAs). The aim of the study is to emphasize phenotype-genotype correlations in AOS.

Methods: We studied 29 AOS patients. Read More

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http://dx.doi.org/10.1002/ajmg.a.61364DOI Listing
January 2020

Living Donor Liver Transplantation in Biliary Atresia Children with Pulmonary Hypertension.

Int J Med Sci 2019 14;16(9):1215-1220. Epub 2019 Aug 14.

Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China.

Objective: Though living donor liver transplantation (LDLT) is commonly performed for pediatric patients with biliary atresia (BA), pulmonary hypertension (PH) is seldom encountered or reported previously. The aim of this study is mainly to identify the prevalence of PH in pediatric patients undergoing liver transplantation and assess whether PH significantly augment the operative risk and evaluate the outcomes in this series of patients.

Design: Retrospectively cohort study. Read More

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http://dx.doi.org/10.7150/ijms.34073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775259PMC

The outcome of real-time evaluation of biliary flow using near-infrared fluorescence cholangiography with Indocyanine green in biliary atresia surgery.

J Pediatr Surg 2019 Dec 2;54(12):2574-2578. Epub 2019 Sep 2.

Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Indocyanine green (ICG) fluorescence imaging is a promising tool for intraoperative decision-making. The aim of this study was to evaluate the utility of near-infrared fluorescence cholangiography (NIR-FCG) with ICG in primary surgery for biliary atresia (BA).

Methods: We performed NIR-FCG with ICG in 10 BA patients and observed the fluorescence of their hilar micro-bile ducts and hilar exudate in order to assess the appropriate level at which to dissect the hilar fibrous corn. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.08.029DOI Listing
December 2019
1 Read

Tc-99m PMT scintigraphy in the diagnosis of pediatric biliary atresia.

Jpn J Radiol 2019 Dec 30;37(12):841-849. Epub 2019 Sep 30.

Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Purpose: Hepatobiliary scintigraphy plays an important role in the differentiation of biliary atresia (BA) and non-BA. The usefulness of Tc-iminodiacetic acid (IDA) derivatives in BA diagnosis is reported in several papers. In contrast, there are no comprehensive data on differentiating BA from non-BA using Tc-N-pyridoxyl-5-methyl-tryptophan (PMT). Read More

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http://dx.doi.org/10.1007/s11604-019-00882-8DOI Listing
December 2019

Intrahepatic cystic lesions in children with biliary atresia after Kasai procedure.

J Pediatr Surg 2019 Dec 30;54(12):2565-2569. Epub 2019 Aug 30.

Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai Key Laboratory of Birth Defect, Shanghai, China. Electronic address:

Background: Intrahepatic cystic lesion (ICL) is a common complication for biliary atresia post-Kasai portoenterostomy. The purpose of this study was to review the cases in our hospital and assess the correlation between characteristics of ICL and clinical outcomes.

Methods: We retrospectively analyzed 787 cases of biliary atresia from 2012 to 2016. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.08.027DOI Listing
December 2019
1 Read

Needle liver biopsy has potential for delaying Kasai portoenterostomy and Is obsolete for diagnosing biliary atresia in the laparoscopic era.

J Pediatr Surg 2019 Dec 30;54(12):2570-2573. Epub 2019 Aug 30.

Department of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Aim: Early diagnosis is essential for the successful management of biliary atresia (BA). We assessed the efficacy of our diagnostic strategies for BA in the laparoscopic era.

Methods: A retrospective review of the medical records of 132 infants presenting with suspected BA between 1998 and 2018 was performed to assess the efficacy of "basic" tests (blood biochemistry, abdominal ultrasound, and Tc-99m N-pyrydoxyl-5-methyltriptophane liver scintigraphy) and the value of laparoscopic assessment of the porta hepatis and/or cholangiography for choosing between Kasai portoenterostomy (PE) or cholangiodrainage (CD) for treatment. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.08.028DOI Listing
December 2019
1 Read

Balloon-Occluded Retrograde Transvenous Obliteration for Fundal Gastric Variceal Bleeding in a Small Child.

J Vasc Interv Radiol 2019 Oct 27;30(10):1624-1625. Epub 2019 Aug 27.

Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan.

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http://dx.doi.org/10.1016/j.jvir.2019.06.022DOI Listing
October 2019

Congenital or acquired? Obstructive jaundice in reoperated duodenal atresia.

BMJ Case Rep 2019 Aug 28;12(8). Epub 2019 Aug 28.

Paediatric Surgery, KK Women's and Children's Hospital, Singapore.

A 55-day-old boy was transferred to our unit with intestinal obstruction and obstructive jaundice after two neonatal operations for duodenal atresia and intestinal malrotation. Abdominal ultrasound showed dilated intrahepatic and extrahepatic ducts with cut-off at the distal common bile duct (CBD). He underwent emergency laparotomy for adhesive intestinal obstruction with a contained abscess from mid-jejunal perforation. Read More

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http://dx.doi.org/10.1136/bcr-2019-231021DOI Listing
August 2019
3 Reads

Quantitative Imaging in Pediatric Hepatobiliary Disease.

Korean J Radiol 2019 09;20(9):1342-1357

Department of Radiology, Severance Hospital, Severance Pediatric Liver Disease Research Group, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.

Pediatric hepatobiliary imaging is important for evaluation of not only congenital or structural disease but also metabolic or diffuse parenchymal disease and tumors. A variety of ultrasonography and magnetic resonance imaging (MRI) techniques can be used for these assessments. In ultrasonography, conventional ultrasound imaging as well as vascular imaging, elastography, and contrast-enhanced ultrasonography can be used, while in MRI, fat quantification, T2/T2* mapping, diffusion-weighted imaging, magnetic resonance elastography, and dynamic contrast-enhanced MRI can be performed. Read More

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http://dx.doi.org/10.3348/kjr.2019.0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715564PMC
September 2019
2 Reads

Tubercular hemoptysis in a young liver transplanted patient: Case report.

Medicine (Baltimore) 2019 Aug;98(33):e16761

Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II.

Rationale: Liver transplanted patients have excellent survival rates, but infectious complications are a major cause of morbidity and mortality. Diagnosis and treatment of tuberculosis (TB) in liver recipients are very challenging. Specific recommendations for anti-TB treatment in liver transplanted patients are lacking. Read More

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http://Insights.ovid.com/crossref?an=00005792-201908160-0002
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http://dx.doi.org/10.1097/MD.0000000000016761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831413PMC
August 2019
4 Reads

Quantitative Contrast-Enhanced Ultrasound by Sonazoid in the Early Diagnosis of Biliary Atresia: An Experimental Study of Rats With Bile Duct Ligation.

Ultrasound Med Biol 2019 10 22;45(10):2767-2776. Epub 2019 Jul 22.

Department of Medical Ultrasonics, Institute for Diagnostic and Interventional Ultrasound, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P.R. China. Electronic address:

We aimed to investigate the feasibility of quantitative Sonazoid contrast-enhanced ultrasound (CEUS) in the diagnosis of biliary atresia (BA) at an early disease stage. First, liver tissue from 10 patients with BA and 10 patients with infantile hepatitis syndrome (IHS) was immunostained with cluster of differentiation 68 (CD68) to compare Kupffer cell counts. Then, quantitative Sonazoid CEUS was performed to evaluate the hyperplasia of the artery branches during the artery phase and changes in Kupffer cell counts during the Kupffer phase in a rat model of BA (common bile duct ligation). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03015629193067
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http://dx.doi.org/10.1016/j.ultrasmedbio.2019.06.409DOI Listing
October 2019
3 Reads

Biliary Atresia as a Disease Starting In Utero: Implications for Treatment, Diagnosis, and Pathogenesis.

J Pediatr Gastroenterol Nutr 2019 10;69(4):396-403

Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.

Biliary atresia (BA) is the most common reason for pediatric liver transplant. BA's varied presentation, natural history, and treatment with the Kasai portoenterostomy have been well described; however, when BA starts relative to birth has not been clearly defined. In this review, we discuss laboratory, imaging, and clinical data which suggest that most if not all forms of BA may start before birth. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942669PMC
October 2019
3 Reads

Enlarged hepatic hilar lymph node: an additional ultrasonographic feature that may be helpful in the diagnosis of biliary atresia.

Eur Radiol 2019 Dec 11;29(12):6699-6707. Epub 2019 Jul 11.

Department of Medical Ultrasonics, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, No. 18 Daoshan Road, Gulou District, Fuzhou City, 350001, Fujian Province, People's Republic of China.

Objectives: To prospectively assess whether the detection of hepatic hilar lymph nodes (LNs) contributes to the diagnosis of biliary atresia (BA).

Methods: A total of 80 jaundiced infants were enrolled in this study and had abdominal ultrasound (US). The hepatic hilar LNs, the gallbladder classification, and the triangular cord (TC) thickness of all infants were evaluated. Read More

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http://dx.doi.org/10.1007/s00330-019-06339-wDOI Listing
December 2019
2 Reads

Does Supersonic Shear Wave Elastography Help Differentiate Biliary Atresia from Other Causes of Cholestatic Hepatitis in Infants Less than 90 Days Old? Compared with Grey-Scale US.

Biomed Res Int 2019 2;2019:9036362. Epub 2019 Jun 2.

Department of Ultrasound, Hunan Children's Hospital, Changsha, Hunan Province 410007, China.

Purpose: To investigate the diagnostic performance of shear wave elastography (SWE) for measuring liver stiffness to identify and differentiate biliary atresia (BA) from cholestatic hepatitis in infants younger than 90 days.

Methods: A total of 138 infants younger than 90 days with cholestatic hepatitis were examined by SWE. The infants were subclassified into BA and nonbiliary atresia (non-BA) groups. Read More

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http://dx.doi.org/10.1155/2019/9036362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582890PMC
January 2020
6 Reads

Prospective Assessment of Ultrasound Shear Wave Elastography for Discriminating Biliary Atresia from other Causes of Neonatal Cholestasis.

J Pediatr 2019 09 26;212:60-65.e3. Epub 2019 Jun 26.

Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH.

Objective: To prospectively assess the diagnostic performance of ultrasound shear wave elastography (SWE) and hepatobiliary laboratory biomarkers for discriminating biliary atresia from other causes of neonatal cholestasis.

Study Design: Forty-one patients <3 months of age with neonatal cholestasis (direct bilirubin >2 mg/dL) and possible biliary atresia were prospectively enrolled. Both 2-dimensional (2D) and point ultrasound SWE were performed prior to knowing the final diagnosis. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.05.048DOI Listing
September 2019
2 Reads

Serum vitamin D level is inversely associated with liver fibrosis in post Kasai's portoenterostomy biliary atresia patients living with native liver.

PLoS One 2019 26;14(6):e0218896. Epub 2019 Jun 26.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, MacKay Children's Hospital, Taipei, Taiwan.

Objective: This study aims to investigate the association of serum vitamin D (VD) levels with the severity of liver fibrosis (LF) in post Kasai's portoenterostomy biliary atresia (PKBA) patients living with their native liver.

Methods: In this cross-sectional study, carried out in a tertiary Children's Hospital in Taipei, Taiwan, PKBA patients living with their native liver were enrolled. Liver biochemistry data, serum 25-hydroxyvitamin D (25-OHVD), acoustic radiation force impulse (ARFI), and scores of Pediatric Quality of Life questionnaire (PedsQL) were collected. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218896PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594627PMC
February 2020
1 Read

The role of imaging in determining prognosis for primary sclerosing cholangitis: A systematic review.

Saudi J Gastroenterol 2019 May-Jun;25(3):152-158

Department of Medicine, University of Rochester, Rochester, New York, USA.

Background/aims: Primary sclerosing cholangitis (PSC) is a chronic, progressive, fibrotic bile duct disease. Resultant complications include infection, progressive liver disease and cancer. While diagnosis relies extensively on imaging, the role of imaging in determining prognosis is unclear. Read More

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http://dx.doi.org/10.4103/sjg.SJG_478_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526736PMC
April 2020
7 Reads

Triangular Cord Sign on Ultrasonography Does Not Indicate Disease Progression of Biliary Atresia.

Indian J Pediatr 2019 07 26;86(7):656-657. Epub 2019 Apr 26.

Department of Pediatric Surgery, Kobe Children's Hospital, 1-6-7, Minatojima-Minami-machi, Chuo-ku, Hyogo, 650-0047, Japan.

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http://dx.doi.org/10.1007/s12098-019-02967-8DOI Listing

Minimally invasive assessment of hepatic function in children with indocyanine green elimination: a validation study.

Scand J Gastroenterol 2019 Apr 29;54(4):485-491. Epub 2019 Mar 29.

e Department of Clinical Physiology, Nuclear Medicine and PET , Copenhagen University Hospital, Rigshospitalet , Copenhagen Ø , Denmark.

Pediatric liver disease (PLD) covers a variety of etiologies and severities, from mild temporary illness to diseases with fatal outcomes. There is a demand for minimally invasive and reliable measures for assessment of the severity of PLD. Indocyanine green (ICG) elimination kinetics to estimate hepatic function has been used in adults for decades, however, due to invasiveness, the use in PLD is still limited. Read More

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http://dx.doi.org/10.1080/00365521.2019.1591497DOI Listing
April 2019
7 Reads

Noninvasive Evaluation of Liver Fibrosis and Portal Hypertension After Successful Portoenterostomy for Biliary Atresia.

Hepatol Commun 2019 Mar 9;3(3):382-391. Epub 2019 Jan 9.

Pediatric Liver and Gut Research Group and Section of Pediatric Surgery Children's Hospital, Helsinki University Hospital Helsinki Finland.

We investigated noninvasive follow-up markers for histologic liver fibrosis and portal hypertension (PH) in patients with biliary atresia after successful portoenterostomy (PE). Among children with bilirubin <20 µmol/L after PE (n = 39), Metavir fibrosis stage was evaluated at PE and in follow-up protocol liver biopsies (n = 83). PH was defined as endoscopically confirmed esophageal varices or thrombocytopenia associated with splenomegaly. Read More

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http://dx.doi.org/10.1002/hep4.1306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396371PMC
March 2019
6 Reads

Magnetic resonance imaging of fibropolycystic liver disease: the spectrum of ductal plate malformations.

Abdom Radiol (NY) 2019 06;44(6):2156-2171

Radiology Unit, Department of Diagnostic and Therapeutic Services, IRCCS ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Via Tricomi 5, 90127, Palermo, Italy.

Fibropolycystic liver diseases, also known as ductal plate malformations, are a group of associated congenital disorders resulting from abnormal development of the biliary ductal system. These disorders include congenital hepatic fibrosis, biliary hamartomas, polycystic liver disease, choledochal cysts and Caroli disease. Recently, it has been thought to include biliary atresia in this group of diseases, because ductal plate malformations could be implicated in the pathogenesis of this disease. Read More

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http://dx.doi.org/10.1007/s00261-019-01966-9DOI Listing
June 2019
13 Reads

A case report of a challenging diagnosis of biliary atresia in a patient receiving total parenteral nutrition.

BMC Pediatr 2019 03 8;19(1):72. Epub 2019 Mar 8.

Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Background: Total parenteral nutrition (TPN) and biliary atresia (BA) are common causes of cholestasis in infancy. The diagnosis of BA is time sensitive due to an inverse correlation between age at intervention (hepatic portoenterostomy - HPE) and survival without liver transplantation. Clinical, laboratory, and histologic features of BA and parenteral nutrition associated cholestasis (PNAC) are similar, creating a diagnostic dilemma for cholestatic infants on parenteral nutrition. Read More

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http://dx.doi.org/10.1186/s12887-019-1446-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407171PMC
March 2019
3 Reads

Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.

Pediatr Transplant 2019 05 6;23(3):e13384. Epub 2019 Mar 6.

Division of Infectious Disease, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.

In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left lateral segment liver transplant for biliary atresia at age 11 months. Read More

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http://dx.doi.org/10.1111/petr.13384DOI Listing
May 2019
7 Reads

Abernethy Malformation Type 2 and Biliary Atresia Coexistence: A Rare Cause of Infantile Liver Transplant.

Euroasian J Hepatogastroenterol 2018 Jul-Dec;8(2):163-166. Epub 2019 Feb 1.

Department of Neonatology, Dr. BehCet Uz Pediatric Diseases and Surgery Education Research Hospital, Izmir, Turkey.

Introduction: Abernethy malformation is a very rare condition in which mesenteric venous blood is drained into systemic circulation by an extra hepatic portosystemic shunt. Here we present a case of a female in infantile period who is a liver transplant candidate with biliary atresia and ventricular septal defect (VSD) accompanying Abernethy malformation type 2.

Case Report: The patient who underwent Kasai operation at postnatal day 35 was identified as a liver transplant candidate in the postnatal month 6 due to growth retardation in the infantile period, insufficient weight gain and liver failure (portal hypertension and massive gastrointestinal bleeding). Read More

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http://dx.doi.org/10.5005/jp-journals-10018-1283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395480PMC
February 2019
13 Reads

Outcome of non-visualization of fetal gallbladder on second-trimester ultrasound: cohort study and systematic review of literature.

Ultrasound Obstet Gynecol 2019 Nov;54(5):582-588

Maternité, Hôpital Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Université Paris Descartes, Paris, France.

Objectives: To investigate the ultrasound characteristics and outcome of fetuses with non-visualization of the fetal gallbladder (NVFGB) followed in our tertiary university hospital, and to provide a comprehensive review of the literature on prenatal findings and outcome of NVFGB.

Methods: NVFGB was defined as non-visualization of the gallbladder on two targeted ultrasound examinations performed within a 1-week period. First, we reviewed the medical records of NVFGB cases managed in our center over a 9-year period. Read More

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http://dx.doi.org/10.1002/uog.20252DOI Listing
November 2019
2 Reads

Neonatal Jaundice.

Indian J Pediatr 2019 09 21;86(9):830-841. Epub 2019 Feb 21.

Department of Radio-Diagnosis, All India Institute of Medical Sciences, New Delhi, India.

Hyperbilirubinemia is a common occurrence in neonates; it may be physiological or pathological. Conjugated hyperbilirubinemia may result from medical or surgical causes, and can result in irreversible liver damage if untreated. The aim of imaging is the timely diagnosis of surgical conditions like biliary atresia and choledochal cysts. Read More

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http://link.springer.com/10.1007/s12098-019-02856-0
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http://dx.doi.org/10.1007/s12098-019-02856-0DOI Listing
September 2019
15 Reads

Is "gallbladder length-to-width ratio" useful in diagnosing biliary atresia?

J Pediatr Surg 2019 Sep 23;54(9):1946-1952. Epub 2019 Jan 23.

Pediatric Surgery Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Thailand.

Background: The accurate assessment of gallbladder shape and wall abnormalities by ultrasound (US) in diagnosing biliary atresia (BA) remains a subjective determination. The objective of this study was to examine the reliability of gallbladder length-to-width ratio (LTWR) by US measurement for diagnosis of BA.

Methods: One hundred infants with conjugated hyperbilirubinemia and unknown cause of jaundice who underwent transabdominal US from February 2009 to February 2017 were enrolled. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.008DOI Listing
September 2019
4 Reads

Ultrasound findings in paediatric cholestasis: how to image the patient and what to look for.

J Ultrasound 2020 Mar 12;23(1):1-12. Epub 2019 Feb 12.

Department of Radiology, "Federico II" University Hospital, Naples, Italy.

Paediatric biliary tract and gallbladder diseases include a variety of entities with a wide range of clinical presentations. Cholestasis represents an impaired secretion of bilirubin by hepatocytes, manifesting with high blood levels of conjugated bilirubin and jaundice. Various causes may be involved, which can be recognised analysing blood tests and hepatobiliary imaging, while sometimes liver biopsy or surgery may be necessary. Read More

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http://dx.doi.org/10.1007/s40477-019-00362-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010886PMC
March 2020
22 Reads

Design and validation of a noninvasive diagnostic criteria for biliary atresia in infants based on the STROBE compliant.

Medicine (Baltimore) 2019 Feb;98(6):e13837

Department of Infection, The Second Affiliated Hospital of Xi'an Jiaotong University.

It is difficult for clinicians to distinguish biliary atresia (BA) from other causes of neonatal cholestasis (NC) at an early stage. The aim of this study was to design and validate noninvasive diagnostic criterion for early diagnosis of BA in infants.In this retrospective cohort study, a total of 482 medical records of patients with NC were recruited to design diagnostic criteria. Read More

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http://dx.doi.org/10.1097/MD.0000000000013837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380858PMC
February 2019
16 Reads

Prenatal sonographic diagnosis of biliary tract malformations.

J Clin Ultrasound 2019 Jun 6;47(5):292-297. Epub 2019 Feb 6.

Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Congenital anomalies of the biliary tract include a variety of pathologic conditions, such as biliary atresia, choledochal cysts, gallbladder agenesis, congenital cholelithiasis, and gallbladder duplication. Although most of these malformations are rare and benign conditions, they may occasionally represent a major threat to extrauterine life. Visualization of a normal-sized gallbladder should be a mandatory component of the second-trimester anomaly ultrasound scan. Read More

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http://dx.doi.org/10.1002/jcu.22705DOI Listing
June 2019
7 Reads

Technical Feasibility and Clinical Effectiveness of Transjugular Intrahepatic Portosystemic Shunt Creation in Pediatric and Adolescent Patients.

J Vasc Interv Radiol 2019 02;30(2):178-186.e5

Division of Interventional Radiology, Department of Radiology, University of Washington, Seattle, Washington; Seattle Children's Hospital, Seattle, Washington.

Purpose: To examine the technical feasibility and clinical efficacy of transjugular intrahepatic portosystemic shunt (TIPS) creation in children and adolescents.

Materials And Methods: Retrospective review was performed of 59 patients (mean age 12.6 y [range, 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10510443183158
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http://dx.doi.org/10.1016/j.jvir.2018.10.003DOI Listing
February 2019
15 Reads
2.149 Impact Factor

Predicting gastroesophageal varices through spleen magnetic resonance elastography in pediatric liver fibrosis.

World J Gastroenterol 2019 Jan;25(3):367-377

Department of Radiology, Severance Hospital, Severance Pediatric Liver Disease Research Group, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 03722, South Korea.

Background: A recent retrospective study confirmed that hepatic stiffness and splenic stiffness measured with magnetic resonance elastography (MRE) are strongly associated with the presence of esophageal varices. In addition, strong correlations have been reported between splenic stiffness values measured with MRE and hepatic venous pressure gradients in animal models. However, most studies have been conducted on adult populations, and previous pediatric MRE studies have only demonstrated the feasibility of MRE in pediatric populations, while the actual clinical application of spleen MRE has been limited. Read More

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https://www.wjgnet.com/1007-9327/full/v25/i3/367.htm
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http://dx.doi.org/10.3748/wjg.v25.i3.367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343098PMC
January 2019
25 Reads

Ultrasound Evaluation of Biliary Atresia Based on Gallbladder Classification: Is 4 Hours of Fasting Necessary?

J Ultrasound Med 2019 Sep 25;38(9):2447-2455. Epub 2019 Jan 25.

Department of Medical Ultrasonics, Institute for Diagnostic and Interventional Ultrasound, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Objectives: The aim of this study was to evaluate the influence of fasting time on the ultrasound identification and exclusion of biliary atresia in jaundiced infants through the use of the gallbladder classification scheme and to test the value of the gallbladder classification scheme in the diagnosis of biliary atresia in inexperienced individuals.

Methods: A total of 188 jaundiced infants were enrolled in this study. All patients received detailed abdominal sonograms. Read More

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http://dx.doi.org/10.1002/jum.14943DOI Listing
September 2019
1 Read
1.532 Impact Factor

Biliary Atresia-associated Cholangitis: The Central Role and Effective Management of Bile Lakes.

J Pediatr Gastroenterol Nutr 2019 04;68(4):488-494

Section of Pediatric Surgery, Pediatric Liver and Gut Research Group and Pediatric Research Center, Children's Hospital, Helsinki University Hospital.

Objectives: Cholangitis and bile lakes are incompletely understood complications after portoenterostomy (PE). We investigated relationships between recurrent cholangitis, bile lakes, and clinical outcomes as well as surgical management of bile lakes.

Methods: In this retrospective observational single institution study medical records and imaging studies of all patients who had undergone PE for biliary atresia during 1987 to 2016 (N = 61) were reviewed. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002243DOI Listing
April 2019
5 Reads