905 results match your criteria Biliary Atresia Imaging

Exploratory application of indocyanine green quantification in biliary atresia Observational study.

Photodiagnosis Photodyn Ther 2022 Jun 9:102960. Epub 2022 Jun 9.

Department of Neonatal Surgery, Neonatal Center, Beijing Children Hospital, Capital Medical University, Beijing 100045, China. Electronic address:

Background: Indocyanine green (ICG) is known to facilitate real-time imaging of the bile outflow during the Kasai procedure. This study explored more possibilities for applying ICG quantification in biliary atresia (BA).

Methods: We enrolled nine BA patients in this study. Read More

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Ultrasound elastography in the diagnosis of biliary atresia in pediatric surgery: a systematic review and meta-analysis of diagnostic test.

Transl Pediatr 2022 May;11(5):748-756

Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: Biliary atresia (BA) is one of the most fatal hepatobiliary diseases in infants and young children, and is easy to cause obstructive jaundice in infants and children, and liver transplantation in children. BA and infantile hepatitis syndrome are the main causes of cholestatic jaundice. The early clinical manifestations are extremely similar, and timely identification is difficult. Read More

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Imaging in Pediatric Obstructive Jaundice.

Indian J Pediatr 2022 Jun 2. Epub 2022 Jun 2.

Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Cholestatic jaundice characterized by elevated conjugated bilirubin can be due to multitude of factors in neonates and childhood. Extrahepatic biliary atresia (EHBA), choledochal cyst, neonatal hepatitis, cytomegalovirus (CMV), and biliary plug are some of the common causes in neonate and early infancy. Causes in late infancy and childhood comprises viral hepatitis, choledochal cyst, cholelithiasis, worm infestation, and biliary compression secondary to extrinsic causes (node, collection, tumor). Read More

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Comparison of Two Kinds of Two-Dimensional Shear Wave Elastography Techniques in the Evaluation of Jaundiced Infants Suspected of Biliary Atresia.

Diagnostics (Basel) 2022 Apr 27;12(5). Epub 2022 Apr 27.

Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou 510080, China.

Purpose: To compare the reliability and performance of Supersonic shear wave elastography (S-SWE) and Toshiba shear wave elastography (T-SWE) in the diagnosis of biliary atresia (BA) and assessment of liver fibrosis among jaundiced infants suspected of BA.

Material And Methods: A total of 35 patients with suspected BA who underwent both S-SWE and T-SWE examinations were prospectively included. Diagnostic performances of S-SWE and T-SWE in identifying BA were evaluated. Read More

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Vascular Complications in Pediatric Liver Transplants and Their Management.

Exp Clin Transplant 2022 05;20(Suppl 3):72-75

From the Department of General Surgery, Division of Transplantation, Baskent University Faculty of Medicine, Ankara, Turkey.

Objectives: The blood supply of the liver occurs through the hepatic artery and portal vein. Outflow of blood circulation in the liver is via the hepatic veins. Any disruption in this blood circulation results in deterioration of liver functions. Read More

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Long-term follow-up of biliary atresia using liver transient elastography.

Pediatr Surg Int 2022 Jul 6;38(7):1013-1018. Epub 2022 May 6.

Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China.

Objective: Liver transient elastography (TE) using FibroScan® has gained popularity as a non-invasive technique to assess hepatic fibrosis by measuring liver stiffness. This study focused on biliary atresia patients post Kasai operation for more than 10 years to prospectively correlate the hepatic fibrosis score to the biochemical changes of liver fibrosis and clinical development of portal hypertensive complications.

Methods: TE was performed in 37 patients who had biliary atresia post Kasai operation done at median age of 60 days. Read More

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Non-visualisation of fetal gallbladder in a Chinese cohort.

Hong Kong Med J 2022 04 20;28(2):116-123. Epub 2022 Apr 20.

Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

Introduction: Non-visualisation of fetal gallbladder (NVFGB) is associated with chromosomal abnormalities, biliary atresia, cystic fibrosis, and gallbladder agenesis in Caucasian fetuses. We investigated the outcomes of fetuses with NVFGB in a Chinese cohort.

Methods: This retrospective analysis included cases of NVFGB among Chinese pregnant women at five public fetal medicine clinics in Hong Kong from 2012 to 2019. Read More

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Features of Nodules in Explants of Children Undergoing Liver Transplantation for Biliary Atresia.

J Clin Med 2022 Mar 13;11(6). Epub 2022 Mar 13.

Swiss Pediatric Liver Center, Geneva University Hospitals, 1205 Geneva, Switzerland.

(1) Background: In patients with biliary atresia (BA) liver nodules can be identified either by pre-transplant imaging or on the explant. This study aimed to (i) analyze the histopathology of liver nodules, and (ii) to correlate histopathology with pretransplant radiological features. (2) Methods: Retrospective analysis of liver nodules in explants of BA patients transplanted in our center (2000-2021). Read More

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Percutaneous ultrasound-guided cholecystocholangiography with microbubbles combined with liver biopsy for the assessment of suspected biliary atresia.

Pediatr Radiol 2022 05 2;52(6):1075-1085. Epub 2022 Mar 2.

Department of Medical Ultrasonics, First Affiliated Hospital, Institute for Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, 58 Zhongshan Road 2, Guangzhou, 510080, People's Republic of China.

Background: Percutaneous ultrasound (US)-guided cholecystocholangiography is effective in diagnosing biliary atresia for infants with a gallbladder >1.5 cm in length on US. However, whether it is still effective for other types of gallbladders needs further clarification. Read More

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Cystic biliary atresia in a neonate with antenatally detected abdominal cyst.

BMJ Case Rep 2022 Feb 28;15(2). Epub 2022 Feb 28.

Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman

Cystic biliary atresia (BA) is a rare but an important type of BA. An antenatally detected cystic lesion at the porta hepatis raises the suspicion of cystic BA. It is very important to differentiate this from choledochal cyst in infants with cholestasis and cystic lesions. Read More

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February 2022

Cholangitis Definition and Treatment after Kasai Hepatoportoenterostomy for Biliary Atresia: A Delphi Process and International Expert Panel.

J Clin Med 2022 Jan 19;11(3). Epub 2022 Jan 19.

Division of Child's and Adolescent's Surgery, Swiss Pediatric Liver Center, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

(1) Background: Acute cholangitis during the first year after Kasai hepatoportoenterostomy (HPE) has a negative impact on patient and native liver survival. There are no consistent guidelines for the definition, treatment, and prophylaxis of cholangitis after HPE. The aim of this study was to develop definition, treatment, and prophylaxis guidelines to allow for expeditious management and for standardization in reporting. Read More

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January 2022

Long-Term Outcome After Tacrolimus-Related Neurotoxicity in Pediatric Living Donor Liver Transplantation.

Transplant Proc 2022 Mar 21;54(2):468-471. Epub 2022 Jan 21.

Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

Background: Tacrolimus-related neurotoxicity is a serious complication. Posterior reversible encephalopathy syndrome, which is severe neurotoxicity after pediatric living donor liver transplantation (LDLT), is a medication-induced complication related to calcineurin inhibitors. The purpose of this study was to evaluate the long-term outcome of tacrolimus-related neurotoxicity after pediatric LDLT. Read More

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Features of Cirrhotic Cardiomyopathy Early in the Lives of Infants With Biliary Atresia Correlate With Outcomes Following Kasai Portoenterostomy.

Hepatol Commun 2022 Jun 21;6(6):1413-1424. Epub 2022 Jan 21.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA, USA.

Cirrhotic cardiomyopathy (CCM), detected during two-dimensional echocardiography (2DE), is prevalent in patients with biliary atresia (BA) awaiting transplant. Whether CCM occurs early in the lives of infants with BA is unknown. The aim of this study was to explore the incidence and consequence of CCM in patients with BA, focusing on the earliest ages when 2DE was performed. Read More

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Ultrasound for the Diagnosis of Biliary Atresia: From Conventional Ultrasound to Artificial Intelligence.

Diagnostics (Basel) 2021 Dec 27;12(1). Epub 2021 Dec 27.

Department of Medical Ultrasonics, Institute for Diagnostic and Interventional Ultrasound, The First Affiliated Hospital, Sun Yat-sen University, No 58, Zhongshan Er Road, Guangzhou 510080, China.

Biliary atresia is an aggressive liver disease of infancy and can cause death without timely surgical intervention. Early diagnosis of biliary atresia is critical to the recovery of bile drainage and long-term transplant-free survival. Ultrasound is recommended as the initial imaging strategy for the diagnosis of biliary atresia. Read More

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December 2021

Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients.

J Laparoendosc Adv Surg Tech A 2022 Mar 17;32(3):320-324. Epub 2022 Jan 17.

Department of General Surgery, Atatürk University Research Hospital, Erzurum, Turkey.

Endoscopic retrograde cholangiopancreatography (ERCP) is an advanced endoscopic technique used in the diagnosis and treatment of pancreaticobiliary system. ERCP is used less frequently in children than in adults due to the rarity of pancreaticobiliary diseases and technical difficulties. However, ERCP is a safe, effective diagnosis and treatment tool for children. Read More

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Imaging diagnosis of a giant choledochal cyst in an infant.

Radiol Case Rep 2022 Feb 4;17(2):404-411. Epub 2021 Dec 4.

Department of Pathology, School of Medical Sciences and Research, Sharda Hospital, Sharda University, Greater Noida, 201306 UP, India.

The usual etiologies of giant abdominal cystic masses in infants are mesenteric cyst, enteric duplication cyst, ovarian cyst in females, cystic lymphangioma, however, the presentation of a choledochal cyst in a gigantic form, is unusual. The primary modality for diagnosis of this entity is ultrasound, followed by MRI. The characteristic ultrasound features of a choledochal cyst are a well-defined cystic lesion which may be found to replace any segment of the biliary tree and is distinctly separate from the gallbladder. Read More

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February 2022

Latest diagnostic performance of different ultrasonic features for biliary atresia.

Acta Radiol 2021 Dec 2:2841851211055820. Epub 2021 Dec 2.

Department of Medical Ultrasonics, 159390Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, PR China.

Background: Early diagnosis of biliary atresia (BA) is an important clinical challenge.

Purpose: To summarize the latest diagnostic performance of different ultrasonic (US) features for BA.

Material And Methods: MeSH terms "biliary atresia" and "ultrasonography" and related hyponyms were used to search PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials. Read More

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December 2021

Diagnosis of liver cirrhosis with two-dimensional shear wave elastography in biliary atresia before Kasai portoenterostomy.

Pediatr Surg Int 2022 Feb 30;38(2):209-215. Epub 2021 Nov 30.

Department of General Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Xicheng District, Beijing, 100045, People's Republic of China.

Purpose: To evaluate the application value of two-dimensional shear wave elastography (2D-SWE) for non-invasive diagnosis of liver cirrhosis (LC) in patients with biliary atresia (BA) before Kasai portoenterostomy (KP), and the cutoff value of liver stiffness measurement (LSM) for diagnosing LC.

Methods: The clinical data of 51 patients with BA who were diagnosed via surgery and pathological results from May 2017 to December 2018 in the department of general surgery, Beijing Children's Hospital, Capital Medical University, were retrospectively analyzed. The liver tissue specimens obtained during KP were evaluated according to the METAVIR criteria. Read More

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February 2022

Machine Learning Evaluation of Biliary Atresia Patients to Predict Long-Term Outcome after the Kasai Procedure.

Bioengineering (Basel) 2021 Oct 22;8(11). Epub 2021 Oct 22.

Department of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.

Kasai portoenterostomy (KP) represents the first-line treatment for biliary atresia (BA). The purpose was to compare the accuracy of quantitative parameters extracted from laboratory tests, US imaging, and MR imaging studies using machine learning (ML) algorithms to predict the long-term medical outcome in native liver survivor BA patients after KP. Twenty-four patients were evaluated according to clinical and laboratory data at initial evaluation (median follow-up = 9. Read More

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October 2021

An Unusual Cause of Cholestasis in an Infant: Biliary Atresia Type IIB.

Indian J Radiol Imaging 2021 Jul 6;31(3):689-692. Epub 2021 Oct 6.

Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Biliary atresia (BA) is a progressive destructive cholangiopathy of unknown etiology that presents in early infancy. It has a worldwide frequency of 1:8,000-1:15,000 and is common in Asia than in the west. Based on the level at which the lumen of the extrahepatic duct is obliterated, BA is classified into three types. Read More

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Liver Transplantation for Biliary Atresia in Adulthood: Single-Centre Surgical Experience.

J Clin Med 2021 Oct 26;10(21). Epub 2021 Oct 26.

Liver Transplant Surgery, Institute of Liver Studies, King's College Hospital, London WC2R 2LS, UK.

Background: Biliary atresia (BA) is the most common indicator for liver transplant (LT) in children, however, approximately 22% will reach adulthood with their native liver, and of these, half will require transplantation later in life. The aim of this study was to analyse the surgical challenges and outcomes of patients with BA undergoing LT in adulthood.

Methods: Patients with BA requiring LT at the age of 16 or older in our unit between 1989 and 2020 were included. Read More

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October 2021

Novel technique for recanalization of severe hepaticojejunal obstruction using a transseptal needle in a pediatric liver transplant recipient.

Pediatr Transplant 2022 Mar 11;26(2):e14160. Epub 2021 Oct 11.

Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Endoscopic and PTB interventions are common nonsurgical interventions for biliary anastomotic strictures that occur after liver transplantation. When these nonsurgical interventions fail, surgical re-anastomosis is considered; however, this is quite invasive and can cause additional injury that may lead to graft loss. We report a case in which conventional nonsurgical interventions failed, but a new method that involve the use of a transseptal needle-a device to create a transseptal left-heart access during cardiac catheter interventions-was successfully used in recanalization of the hepaticojejunal anastomotic obstruction. Read More

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Hemodynamic analysis of hepatic arteries for the early evaluation of hepatic fibrosis in biliary atresia.

Comput Methods Programs Biomed 2021 Nov 20;211:106400. Epub 2021 Sep 20.

Department of Medical Imaging, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai 200127, China. Electronic address:

Background And Objective: Hepatic fibrosis is the prominent characteristic of biliary atresia (BA), may even progress continually after Kasai procedure (KP). BA, as a devastating pediatric hepatic disease, mainly leads to newborn cholestasis, even liver cirrhosis, eventually hepatic failure. Earlier diagnosis of hepatic fibrosis, which used to be detected by liver biopsy commonly, is consistent with better outcomes of KP. Read More

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November 2021

The triangular cord ratio and the presence of a cystic lesion in the triangular cord. Suggested new ultrasound findings in the early diagnosis of Biliary Atresia.

Pediatr Surg Int 2021 Dec 15;37(12):1693-1697. Epub 2021 Sep 15.

Department of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.

Background: In biliary atresia (BA), the ultrasonic triangular cord (TC) sign is positive at ≥ 3 mm, but sometimes there is BA even if it is ≤ 3 mm. For improving the ultrasonographic diagnosis, we have established a new evaluation, adding the ratio of the anterior/posterior thickness (TC ratio) in the hyperechoic area and the presence of a cystic lesion in the triangular cord (TCC).

Methods: We examined 24 cases of suspected BA who demonstrated acholic stools from 2006 to 2020. Read More

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December 2021

Comparison between cystic biliary atresia and choledochal cyst: a clinical controlled study.

Pediatr Surg Int 2022 Jan 15;38(1):109-114. Epub 2021 Sep 15.

Department of General Surgery, Capital Institute of Pediatrics, Beijing, China.

Purpose: It is difficult to distinguish cystic biliary atresia (CBA) from choledochal cyst (CC) before intraoperative cholangiography in neonates or young infants because of the similar ultrasonographic patterns and clinical manifestations. This study is to investigate the difference of clinical parameters between CBA and CC.

Methods: 96 patients with cyst at hepatic hilum whose ages were less than 120 days during the period from Jan'2013 to Nov'2015 were retrospectively studied, they were divided into CBA group and CC group by intraoperative cholangiography, there were 29 cases of CBA and 67 cases of CC. Read More

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January 2022

The postoperative choledochoscopy in the management of the residual hepatolithiasis involving the caudate lobe: A retrospective study.

Medicine (Baltimore) 2021 Sep;100(35):e26996

Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China.

Abstract: To reveal the role of the postoperative choledochoscopy in treating the residual calculi in the caudate lobe (CL) of the liver.We recruited 66 patients with T-tube/percutaneous transhepatic cholangioscopy tract who still had residual gallstones in the CL at least 6 weeks after the operation. Imaging examinations determined the gallstones' locations in the patients, and all of them underwent the postoperative choledochoscopic examination through the T-tube/percutaneous transhepatic cholangioscopy tract for therapeutic intervention. Read More

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September 2021

Complete Absence of the Extrahepatic Biliary Tree in a Newborn With Pigmented Stools.

Pediatrics 2021 07 18;148(1). Epub 2021 Jun 18.

Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics

"Yellow stools in neonatal cholestasis exclude biliary atresia." This conventional wisdom led to the development of the infant stool color card, which alerts parents to seek medical referral when pale stools are observed, a strategy that has been shown to improve survival in infants with biliary atresia (BA). Here, we present a case of a newborn with significant direct hyperbilirubinemia (direct bilirubin level of up to 9. Read More

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Recent advances in the use of ultrasound and related techniques in diagnosing and predicting outcomes in biliary atresia.

Curr Opin Pediatr 2021 10;33(5):515-520

Section of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, Baylor College of Medicine.

Purpose Of Review: Biliary atresia (BA) is the leading cause of chronic liver disease and the most common indication for pediatric liver transplantation. The use of ultrasound (US) and related techniques continues to evolve to help diagnose BA as well as potentially to help predict outcomes after treatment with the Kasai portoenterostomy (KP).

Recent Findings: There are no US findings that are definitive for BA; however, signs which are consistent with BA include gallbladder abnormalities, the triangular cord sign, presence of hepatic subcapsular flow, and hilar lymphadenopathy. Read More

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October 2021

Accuracy of hepatobiliary scintigraphy and added value of SPECT/CT versus planar imaging for diagnosing biliary atresia.

Hell J Nucl Med 2021 May-Aug;24(2):108-113. Epub 2021 Aug 6.

Department of Nuclear Medicine, Aalborg University Hospital, Hobrovej 18-22, DK-9000 Aalborg, Aalborg, Denmark.

Objective: Hepatobiliary scintigraphy (HBS) is an important tool in diagnosing biliary atresia in infants. There is limited evidence on the use of single photon emission computed tomography/computed tomography (SPECT/CT) as an additional imaging method to planar imaging. We evaluated the value of SPECT/CT in unclear cases of planar HBS. Read More

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January 2022

Neonatal diagnosis of biliary atresia: a practical review and update.

Pediatr Radiol 2022 Apr 31;52(4):685-692. Epub 2021 Jul 31.

Department of Radiology, Cleveland Clinic, 9500 Euclid Ave., Mail Code L10, Cleveland, OH, 44193, USA.

Biliary atresia is challenging to diagnose because many of the clinical and imaging features of this condition overlap with those of other causes of cholestasis in newborns. When jaundice persists beyond 2 weeks of age, the neonate should be evaluated for cholestasis, and biliary atresia - the most common cause of neonatal cholestasis - should be considered. It is critical to diagnose biliary atresia early because failure to treat can result in hepatic fibrosis and death in less than 1 year. Read More

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