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Ann Surg Oncol 2020 Jul 10. Epub 2020 Jul 10.

Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.

Background: To date, postoperative prognostic factors for intraductal papillary neoplasm of the bile duct (IPNB) have not been well-established. This study aimed to examine the histopathologic features and postoperative prognosis of the two IPNB subclassifications, as well as factors affecting prognosis, based on the authors' experience at a single institution.

Methods: The study enrolled 83 patients who underwent surgical resection for pathologically diagnosed IPNB at the authors' institution. Read More

Cancer Cytopathol 2020 Jul 10. Epub 2020 Jul 10.

Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal.

In diagnostic cytology, the known site-specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exact nature of the specimen received, the staining method(s) used, and the use of additional laboratory techniques including molecular profiling; furthermore, they often differ to some extent from institution to institution, between differing cytologists within the same institution, and over time. A brief literature review for a selected group of routine diagnostic cytology specimens shows a published ROM for a confirmed malignant diagnosis as follows: bile duct brushings, ~99% (range, 97%-100%); breast fine needle aspiration, 98. Read More

Clin Nurs Res 2020 Jul 10:1054773820940873. Epub 2020 Jul 10.

Linköping University, Linköping, Sweden.

The study aimed to explore the experiences of participation among the next of kin of patients who had surgery for upper abdominal tumours. This study had a qualitative research design and data were analysed by thematic analysis. Eleven qualitative interviews were conducted with next of kin to patients who had surgery for liver, bile duct or pancreatic malignancy. Read More

Int J Surg 2020 Jun 30. Epub 2020 Jun 30.

Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

A dilemma of graft selection between right or left livers occurs during the planning of living-donor liver transplantation (LDLT) as well as splitting a whole liver graft into full right/full left grafts in deceased-donor liver transplantation. The right liver's relation to the whole liver could be considered as the trunk of a tree; it has a larger volume, the main axis of bile ducts, and the inferior vena cava mainly belongs to the right liver. Therefore, it was considered as the standard graft in LDLTs. Read More

Sci Rep 2020 Jul 2;10(1):10858. Epub 2020 Jul 2.

Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, 8200, Aarhus N, Denmark.

Normal liver tissue is highly vulnerable towards irradiation, which remains a challenge in radiotherapy of hepatic tumours. Here, we examined the effects of radiation-induced liver injury on two specific liver functions and hepatocellular regeneration in a minipig model. Five Göttingen minipigs were exposed to whole-liver stereotactic body radiation therapy (SBRT) in one fraction (14 Gy) and examined 4-5 weeks after; five pigs were used as controls. Read More

Sci Rep 2020 Jul 2;10(1):10883. Epub 2020 Jul 2.

Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei City, 10002, Taiwan.

Irreversible electroporation (IRE) is a non-thermal ablation modality that has been shown to be safe and effective in its application to tumors that are close to risky areas. This study aims to assess the safety and efficacy of IRE for unresectable hilar cholangiocarcinoma. Nine patients from two medical centers in Asia received IRE treatment between June 2015 and July 2017. Read More

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):512-515

Department of Gastroenterology and Pancreatic Surgery, Zhejiang Province People's Hospital, Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, China.

To summarize the characteristics and difficulties of minimal invasive surgery for adolescent with pancreatic head tumor. The data of adolescent younger than 28 years old with pancreatic head tumor treated at Department of Gastroenterology and Pancreatic Surgery, Zhejiang Province People's Hospital from January 2014 to December 2019 were analyzed retrospectively. Fifteen cases were enrolled, included 5 males and 10 females. Read More

Gastroenterology 2020 Jun 26. Epub 2020 Jun 26.

Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Surg Case Rep 2020 Jun 26;6(1):150. Epub 2020 Jun 26.

Department of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.

Background: Gastroenteric neuroendocrine carcinomas (NECs) account for 6.2% of gastroenteric neuroendocrine tumors (NETs), and only 1% or less of gastroenteric NETs occur in the ampulla of Vater (AoV). Clinical features of NEC of the AoV remain obscure. Read More

Tech Vasc Interv Radiol 2020 Jun 25;23(2):100675. Epub 2020 May 25.

Department of Radiology and Nuclear Medicine at the Amsterdam University Medical Center, Vrije Universiteit-Cancer Center Amsterdam in Amsterdam, The Netherlands.

Several minimally invasive image guided tumor ablation techniques have been added to the treatment spectrum for locally advanced pancreatic cancer (LAPC). Irreversible electroporation (IRE) might have a significant additive value in the management of this difficult-to-treat disease. As opposed to thermal ablative techniques, IRE induces cell death by the delivery of high-voltage electrical pulses. Read More

Medicine (Baltimore) 2020 Jun;99(26):e20854

Department of Pathology, Third Central Hospital of Tianjin, Tianjin Third Central Hospital affiliated to Nankai University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases.

Introduction: Although primary hepatic neuroendocrine carcinomas, whose prognostic mechanisms remain unclear, are rare, coexistence of neuroendocrine carcinomas and other tumors is rarer. In this report, we describe a unique case of coexistence between primary hepatic neuroendocrine carcinoma and a distal cholangiocarcinoma in the pancreas.

Patient Concerns: A 64-year-old woman with a history of diabetes, but none of hepatitis, was admitted to hospital because of intermittent epigastric distension and pain discomfort for more than 1 month aggravated 1 day. Read More

Front Oncol 2020 2;10:728. Epub 2020 Jun 2.

Center for Gastroenterology, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.

Pancreatobiliary tumors frequently contain multiple malignant and precancerous lesions; however, the origin of the driver mutations and the mechanisms that underlie the generation of distinct clones within an organ field remain unclear. Herein, we describe a 76-year-old male suffering from moderately differentiated adenocarcinomas of the pancreas that primarily involved the distal bile duct and multiple "dispersing" invasive lesions in the pancreatic head. The patient underwent pylorus-preserving pancreaticoduodenectomy with superior mesenteric vein resection, and targeted sequencing of 18 genes associated with pancreatic tumorigenesis and immunohistochemical analysis of RNF43 and ARID1A were performed on each tumor compartment, including the invasive and non-invasive areas. Read More

Ecancermedicalscience 2020 22;14:1048. Epub 2020 May 22.

Clinica AMO, Assistência Multidisciplinar em Oncologia, Salvador, BA 41950-640, Brazil.

Purpose: As of 2020, the world is facing the great challenge of the COVID-19 (Coronavirus disease 2019) pandemic, caused by the SARS-CoV-2 virus. While the overall mortality is low, the virus is highly virulent and may infect millions of people worldwide. This will consequently burden health systems, particularly by those individuals considered to be at high risk of severe complications from COVID-19. Read More

Surg Oncol 2020 Jun 17;33:270-275. Epub 2020 Feb 17.

Centre of Abdominal Surgery, A.V. Vishnevsky National Medical Research Center of Surgery, Moscow, Russian Federation. Electronic address:

Background: Long-term outcomes depend heavily on the possibility of performing radical resection.

Purpose: To evaluate long-term results in perihilar cholangiocarcinoma (PHC) patients from the perspective of a new understanding of radical resection.

Methods: Consecutive PHC patients who underwent surgical resection at A. Read More

Z Gastroenterol 2020 Jun 16;58(6):583-589. Epub 2020 Jun 16.

Recently published genomic data revealed substantial differences of gallbladder and extrahepatic as well as intrahepatic cholangiocarcinoma. However, these data have no influence on the choice of systemic therapy to date. This review shall provide a concise overview of epidemiology and pathogenesis of gallbladder carcinoma as well as the differences in the mutational profile in comparison to cholangiocarcinoma. Read More

Scand J Gastroenterol 2020 Jun 16:1-7. Epub 2020 Jun 16.

Department of Clinical Sciences Lund, Surgery, Lund University and Skåne University Hospital, Lund, Sweden.

Distal cholangiocarcinoma (dCCA) is a malignancy with a dismal prognosis. One of the hallmarks is the presence of a rich desmoplastic stroma believed to contribute to tumor progression and treatment resistance. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein implicated in tumor-stroma interaction with prognostic correlation across several malignancies. Read More

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620934680

Augusta University Medical Center, Medical College of Georgia, Augusta, GA, USA.

Choledochoduodenal fistula (CDF) is an abnormal communication between the common bile duct and the duodenum. It accounts for about 5% to 25% of the total biliary fistulas and is usually due to a perforated duodenal ulcer, choledocholithiasis, and complications secondary to tuberculosis or could be iatrogenic. Primary intrabilliary tumors usually cause obstructive jaundice and rarely biliary metastasis arising from other organs like colon, breast, and lungs can cause obstructive jaundice. Read More

Nucl Med Commun 2020 07;41(7):714

Department of Gastroenterology, Hitit University Erol Olcok Traning and Research Hospital, Corum, Turkey.

Int J Clin Exp Pathol 2020 1;13(5):1073-1080. Epub 2020 May 1.

Department of Pathology, Shizuoka General Hospital No. 4-27-1, Kita-Ando, Aoi-ku, Shizuoka 420-8527, Japan.

Herein reported is the unique case of a small hepatocellular carcinoma (HCC) with several foci of a minor (10% in area) component of "malignant ductular reactions". The patient was 51-year-old man who was a drinker. HBV/HCV were negative. Read More

J Hepatobiliary Pancreat Sci 2020 Jun 7. Epub 2020 Jun 7.

Department of Internal Medicine, Izumo-city General Medical Center, Izumo, Japan.

A 90-year-old female who previously underwent a cholecystectomy for a gallbladder stone was admitted to our hospital with jaundice. Magnetic resonance cholangiopancreatography (MRCP) revealed left and right bile ducts parallel with the duodenal papilla, and joined distally to form a single short common bile duct with no pancreaticobiliary maljunction (Figure 1). The remnant cystic duct diverged from the right hepatic duct without a common hepatic duct. Read More

Semin Radiat Oncol 2020 Jul;30(3):242-252

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI. Electronic address:

Definitive reirradiation using a stereotactic technique is an effective local treatment option for both recurrent liver metastases and recurrent primary liver cancers. The tolerance of the liver, bile ducts, and surrounding gastrointestinal luminal organs must be respected to ensure safe retreatment. The risks associated with retreatment to these organs must be carefully balanced with the probability of clinical benefit. Read More

Khirurgiia (Mosk) 2020 (5):5-11

Vishnevsky National Medical Research Center of Surgery, Moscow, Russia.

Objective: To evaluate the long-term outcomes of surgical treatment of intrahepatic cholangiocarcinoma depending tumor dimensions, vascular invasion, lymph node metastases, cellular differentiation and quality of resection.

Material And Methods: There were 46 patients with intrahepatic cholangiocellular cancer. Extended hemihepatectomy was made in 14 patients (30. Read More

Zentralbl Chir 2020 Jun 4. Epub 2020 Jun 4.

Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum Erlangen, Deutschland.

A steady improvement in modern imaging as well as increasing age in society have led to an increasing number of cystic pancreatic tumours being detected. Pancreatic cysts are a clinically challenging entity because they span a broad biological spectrum and their differentiation is often difficult, especially in small tumours. Therefore, they require a differentiated indication for indication of surgery. Read More

Acta Radiol 2020 Jun 3:284185120928929. Epub 2020 Jun 3.

Department of General, Visceral and Vascular Surgery, Charité - Universitätsmedizin Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Background: Vascular cooling effects are a well-known source for tumor recurrence in thermal in situ ablation techniques for hepatic malignancies. Microwave ablation (MWA) is an ablation technique to be considered in the treatment of malignant liver tumors. The impact of vascular cooling in MWA is still controversial. Read More

Anticancer Res 2020 Jun;40(6):3417-3421

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, UOC Radioterapia Oncologica, Rome, Italy.

Background/aim: To evaluate the outcome of patients with unresectable extrahepatic cholangiocarcinoma (CC) treated with external-beam radiotherapy (EBRT) and concurrent chemotherapy (CT) with or without intraluminal brachytherapy (ILBT) boost or with definitive ILBT.

Patients And Methods: A pooled analysis of patients with non-metastatic unresectable CC was performed. They were treated in three different institution with EBRT plus CT with or without an ILBT boost. Read More

Zhonghua Zhong Liu Za Zhi 2020 May;42(5):426-431

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

Biological behavior, pathological characteristics and prognostic factors of 355 cases with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) were analyzed in this retrospective study. In our study, 355 patients pathologically diagnosed as GEP-NENs were identified from April 2006 to November 2017 in the Fourth Hospital of Hebei Medical University. The biological behavior, pathological characteristics and prognosis were analyzed retrospectively. Read More

Medicine (Baltimore) 2020 May;99(21):e20237

Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu Province.

Objectives: To compare the clinical outcomes of endoscopic biliary drainage (EBD) with those of percutaneous transhepatic biliary drainage (PTBD) in patients with resectable hilar cholangiocarcinoma (HCCA) and evaluate the effect of EBD and PTBD on tumor prognosis.

Materials And Methods: PubMed, EMBASE, and Cochrane Library databases were searched for articles about the comparison between PTBD and EBD. Data were analyzed by Revman 5. Read More

Medicine (Baltimore) 2020 May;99(21):e19432

Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Self-expandable metallic stent (SEMS) placement is widely used for relieving symptoms in malignant gastric outlet obstruction (MGOO). This study aimed to evaluate the efficacy and safety of multiple gastroduodenal stent placement using the stent-in-stent technique and to identify factors predictive of stent patency.We retrospectively analyzed data from 170 patients with GOO receiving SEMS using the stent-in-stent technique between July 2006 and July 2018. Read More

J Pathol 2020 Jun 1:e5474. Epub 2020 Jun 1.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Advances in tissue clearing and microscopy make it possible to study human diseases in three dimensions (3D). High-grade tumor budding is known to be associated with poor prognosis in various cancers; however, little is known about the 3D architecture of TB. Using tissue clearing, we analyzed the 3D structure of tumor budding and E-cadherin expression in 31 extrahepatic cholangiocarcinomas. Read More

Virchows Arch 2020 Jul 24;477(1):33-45. Epub 2020 May 24.

Service d'Anatomie et Cytologie Pathologiques, AP-HP, Hôpital Saint Antoine, 75012, Paris, France.

Biliary tract carcinomas are divided into intrahepatic, perihilar, distal extrahepatic cholangiocarcinomas, and gallbladder adenocarcinomas. Therapies targeting ROS1, ALK, MET, and HER2 alterations are currently evaluated in clinical trials. We assessed ROS1 and ALK translocations/amplifications as well as MET and HER2 amplifications for each tumor subtype by fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) in 73 intrahepatic, 40 perihilar bile duct, 36 distal extrahepatic cholangiocarcinomas, and 45 gallbladder adenocarcinomas (n = 194). Read More

Clin Imaging 2020 May 3;66:10-17. Epub 2020 May 3.

Abdominal and Cross-Sectional Interventional Radiology, Michigan Medicine, United States of America. Electronic address:

Purpose: Intraductal papillary neoplasm of the bile duct (IPNB) is a precursor to invasive carcinoma and is a distinct pathologic diagnosis. The purpose of this study was to evaluate imaging features of IPNB on cross-sectional imaging studies with histopathologic correlation.

Materials And Methods: In this IRB approved, HIPAA compliant retrospective observational analysis of 23 pathology proven IPNB tumors 22 imaging studies were reviewed, 14 CT and 8 MRI scans. Read More

Sci Rep 2020 May 18;10(1):8179. Epub 2020 May 18.

Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.

Intraductal oncocytic papillary neoplasm (IOPN) is a rare intraductal tumor of the pancreatobiliary system. Currently, little is known about its distinct characteristics, unlike intraductal papillary mucinous neoplasms (IPMN) and intraductal papillary neoplasms of the bile duct (IPNB). The present study compared 22 IOPNs (18 pancreatic and 4 biliary) with those of 61 IPMNs/8 IPNBs. Read More

Lancet Oncol 2020 06 13;21(6):738-739. Epub 2020 May 13.

Medical Oncology Department, Centre Léon Bérard, 69008 Lyon, France. Electronic address:

Surg Case Rep 2020 May 15;6(1):103. Epub 2020 May 15.

Department of Surgery, Matsuyama Red Cross Hospital, 1 Bunkyo-cho, Matsuyama City, Ehime, 790-8524, Japan.

Background: Intraductal papillary neoplasm of the bile duct (IPNB) is characterized by an intraluminal, growing papillary tumor covered by neoplastic biliary epithelial cells with a fine fibrovascular core. IPNB was introduced as a precancerous and early neoplastic lesion in the 2010 World Health Organization classification of tumors of the digestive system. IPNB eventually invades the bile duct wall and progresses to invasive cholangiocarcinoma. Read More

Indian J Surg 2020 May 12:1-7. Epub 2020 May 12.

3Department of Pathology, Atatürk Research and Education Hospital, İzmir Katip Celebi University, İzmir, Turkey.

Hepaticojejunostomy is a challenging and complex procedure to be done with confidence in conditions that contain a large number of segmental bile ducts. Portoenterostomy can be defined as the joining of multiple bile ducts into a single cavity using segmenter bile duct ends, stents, and surrounding connective tissues. During surgery, in cases with advanced stage biliary tract tumors that cannot be performed hepatectomy, after aggressive dissections to provide a negative surgical margin, a large number of segmental bile ducts can be revealed and needs to ensure the continuity of bile flow. Read More

Surg Clin North Am 2020 Jun 16;100(3):535-549. Epub 2020 Apr 16.

Providence Sacred Heart Medical Center, 101 West 8th Avenue, Suite 7050, Spokane, WA 99204, USA.

The incidence of liver cancers has continued to increase over the past few decades and mortality related to liver cancer has increased by more than 2% annually since 2007. This article reviews the essential workup and treatment options necessary for general surgeons as they treat patients with primary liver cancers. Read More

Zhonghua Wai Ke Za Zhi 2020 May;58(5):375-382

First Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangdong Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou 510282, China.

To evaluate the efficacy of three-dimensional(3D) visualization technology in the precision diagnosis and treatment for primary liver cancer. A total of 1 665 patients with primary liver cancer who admitted to seven medical centers in China between January 2009 to January 2019, diagnosed and treated by 3D visualization protocol were analyzed, and their clinical data were retrospectively reviewed. There were 1 255 males(75. Read More

Int J Mol Sci 2020 May 7;21(9). Epub 2020 May 7.

First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi 400-8510, Japan.

We aimed to evaluate a newly developed peroral cholangioscopy (POCS) classification system by comparing classified lesions with histological and genetic findings. We analyzed 30 biopsied specimens from 11 patients with biliary tract cancer (BTC) who underwent POCS. An original classification of POCS findings was made based on the biliary surface's form (F factor, 4 grades) and vessel structure (V-factor, 3 grades). Read More

Am Surg 2020 Apr;86(4):389-390

Abdom Radiol (NY) 2020 May 6. Epub 2020 May 6.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.

This essay aimed to illustrate the various hepatic nodules that may exhibit arterial phase hyperenhancement and washout on computed tomography/magnetic resonance imaging (CT/MRI). Hepatic nodules with arterial phase hyperenhancement and washout on CT/MRI include hepatocellular carcinoma, focal nodular hyperplasia-like nodules, serum amyloid A-positive hepatocellular neoplasms, intrahepatic cholangiocarcinoma, intrahepatic bile duct adenoma, hepatoblastoma, hepatocellular adenoma, hepatic epithelioid angiomyolipoma, and metastasis including neuroendocrine and gastrointestinal stromal tumors. Understanding the imaging findings is important to ensure correct diagnosis. Read More

J Hepatobiliary Pancreat Sci 2020 May 1. Epub 2020 May 1.

Department of Diagnostic Pathology, Yonsei University Medical Center, Seoul, Korea.

Background And Aims: Intraductal papillary neoplasms of bile duct (IPNBs) remain a challenging entity to manage.

Methods: The pathologic spectrum of 34 gastric subtype of IPNB (gIPNB) cases was examined in consideration of the type 1 and 2 subclassification proposed by Japan-Korea consensus and compared with gastric subtype of pancreatic intraductal papillary mucinous neoplasm (gIPMN) (44 cases).

Results: Type 1 gIPNBs (17 cases) showed regular papillary foveola with variable tubular pyloric glands. Read More

Khirurgiia (Mosk) 2020 (4):24-29

Syzganov National Research Centre of Surgery, Almaty, Republic of Kazakhstan.

Objective: Retrospective analysis of patients with periampullary tumors undergoing pancreatoduodenectomy.

Material And Methods: A retrospective review included 48 patients with resectable periampullary tumors. Patients were divided into two groups according to the localization of cancer. Read More

Pathol Int 2020 Apr 29. Epub 2020 Apr 29.

Institute of Liver Studies, King's College Hospital, London, UK.

Most primary liver cancers diagnosed in allograft livers are recurrent tumors of the native liver origin, while donor-derived primary liver cancers are markedly less common. A 21-year-old woman who had liver transplantation for post-Kasai biliary atresia was recently referred for post-transplant biliary stricture. Her transplantation was performed at the age of 6 years using the whole liver graft from a 10-year-old donor and choledocho-jejunostomy. Read More

HPB (Oxford) 2020 Apr 26. Epub 2020 Apr 26.

Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

Background: This meta-analysis was performed by analyzing randomized controlled trials (RCTs) to assess the potential prognostic value of adjuvant chemotherapy (ACT) for patients with resected biliary tract cancers (BTCs).

Methods: PubMed, EMBASE, and the Cochrane Library were searched for relevant articles published. Only RCTs affected by tumors of gallbladder, intrahepatic, perihilar, and distal bile ducts were considered. Read More

Eur Radiol 2020 Apr 28. Epub 2020 Apr 28.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objectives: To identify CT features distinguishing neuroendocrine carcinomas (NECs) of pancreas from well-differentiated neuroendocrine tumors (NETs) according to the World Health Organization 2017 and 2019 classification systems.

Methods: This retrospective study included 69 patients with pathologically confirmed pancreatic neuroendocrine neoplasms who underwent dynamic CT (17, 17, 18, and 17 patients for well-differentiated grade 1, 2, 3 NET and NEC, respectively). CT was used to perform qualitative analysis (component, homogeneity, calcification, peripancreatic infiltration, main pancreatic ductal dilatation, bile duct dilatation, intraductal extension, and vascular invasion) and quantitative analysis (interface between tumor and parenchyma [delta], arterial enhancement ratio [AER], portal enhancement ratio [PER], and dynamic enhancement pattern). Read More

BMJ Case Rep 2020 Apr 27;13(4). Epub 2020 Apr 27.

Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Mixed adenocarcinoma with neuroendocrine tumour of pancreas has been reported infrequently and consists of both epithelial and neuroendocrine component. We encountered an 81-year-old male patient who presented with clinical features of painful progressive jaundice for 1 month. Contrast-enhanced CT abdomen reported a mass in the pancreatic head with dilated common bile duct and pancreatic duct. Read More

HPB (Oxford) 2020 Apr 24. Epub 2020 Apr 24.

Department of Surgery, Radboudumc, P.O. Box 9101, Internal Code 618, 6500 HB, Nijmegen, the Netherlands. Electronic address:

Background: It is controversial whether patients with gallbladder cancer (GBC) presenting with jaundice benefit from resection. This study re-evaluates the impact of jaundice on resectability and survival.

Methods: Data was collected on surgically explored GBC patients in all Dutch academic hospitals from 2000 to 2018. Read More

HPB (Oxford) 2020 Apr 23. Epub 2020 Apr 23.

Department of Pathology, Koç University Hospital, Istanbul, Turkey; Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey. Electronic address:

Background: The cause of most pancreatic and periampullary cancers (PAC) is unknown. Recently, anatomic variations such as pancreatobiliary maljunction have been recognized as risk factors, similar to Barrett-related gastro-esophageal cancers.

Methods: Pre-operative MRI from 860 pancreatic/biliary resections, including 322 PACs, were evaluated for low-union (cystic duct joining the common hepatic duct inside of the pancreas or within 5 mm of the pancreatic border) RESULTS: Low-union, seen <10% of the population, was present in 44% of PACs (73% distal bile duct/cholangiocarcinoma, 42% pancreatic head, and 34% ampullary). Read More

PLoS One 2020 24;15(4):e0221545. Epub 2020 Apr 24.

Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America.

Cancer affects millions of individuals worldwide. One shortcoming of traditional cancer classification systems is that, even for tumors affecting a single organ, there is significant molecular heterogeneity. Precise molecular classification of tumors could be beneficial in personalizing patients' therapy and predicting prognosis. Read More

J Ultrason 2020 31;20(80):e43-e54. Epub 2020 Mar 31.

Department Allgemeine Innere Medizin, Kliniken Hirlsanden Bern Beau Site , Salem und Permanence , Switzerland ; Ultrasound Department, First Affiliated Hospital of Zhengzhou University , China.

Imaging has a very important role in evaluating abdominal pathology. A good knowledge of indications is of crucial importance in the management of the patient with abdominal pathology. Ultrasound, which on its own can lead to an accurate diagnosis, plays a pivotal role in the management of abdominal pathology. Read More