Search Our Scientific Publications & Authors

Gut Liver 2019 Apr 24. Epub 2019 Apr 24.

Department of Gastroenterology, Iida Municipal Hospital, Iida, Japan.

As ultrasound (US) is simple and less invasive than other imaging modalities, this technique is widely used for mass screening. However, visualizing the entire pancreas due to complicated anatomy, obesity and overlying gas can be difficult. US plays a key role in the diagnosis of pancreatic carcinoma (PC), of which tumors smaller than 10 mm (TS1a) and pancreatic carcinoma in situ (PCIS) are expected to have good prognosis. Read More

Gut Liver 2019 Apr 15. Epub 2019 Apr 15.

Department of Hepatobiliary Pancreatic Surgery, Shizuoka Cancer Center, Sunto, Japan.

Intraductal papillary neoplasms of the bile duct (IPNBs) are known to show various pathologic features and biological behaviors. Recently, two categories of IPNBs have been proposed based on their histologic similarities to pancreatic intraductal papillary mucinous neoplasms (IPMNs): type 1 IPNBs, which share many features with IPMNs; and type 2 IPNBs, which are variably different from IPMNs. The four IPNB subtypes were re-evaluated with respect to these two categories. Read More

Gut Liver 2019 Apr 17. Epub 2019 Apr 17.

Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background/aims: : Metallic stents designed to relieve malignant biliary obstruction are susceptible to occlusive tumor ingrowth or overgrowth. In a previous report, we described metallic stents covered with paclitaxel-incorporated membrane (MSCPM-I, II) to prevent occlusion from tumor ingrowth via antitumor effect. This new generation paclitaxeleluting biliary stent is further endowed with sodium caprate (MSCPM-III) for enhanced drug delivery. Read More

Proc (Bayl Univ Med Cent) 2019 Jan 7;32(1):124-125. Epub 2019 Jan 7.

Department of Pathology, Baylor University Medical CenterDallasTexas.

Intraductal papillary neoplasm of the bile duct is characterized by intraductal papillary growth with fibrovascular cores that can grow anywhere along the biliary tree. Most cases have high-grade intraepithelial neoplasia or an associated invasive carcinoma. These tumors can spread superficially along the biliary tree and be multifocal, and preoperative biopsy cannot always reflect the maximum degree of atypia. Read More

Anticancer Res 2019 Apr;39(4):2155-2161

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background/aim: The impact of adjuvant chemotherapy (AC) for extrahepatic cholangiocarcinoma (ECC) remains unclear. This study evaluated the efficacy and limitations of AC.

Patients And Methods: Between 2006 and 2016, 106 patients with stage II-IV ECC who underwent curative resection with biliary tract reconstruction were retrospectively analyzed. Read More

Anticancer Res 2019 Apr;39(4):2139-2144

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.

We report a 64-year-old woman with a 9-cm liver tumor in the left lateral section. The patient had neither hepatitis B or C virus infection, nor cirrhosis. Carbohydrate antigen 19-9 (CA 19-9) level was 1,889 U/ml. Read More

Anticancer Res 2019 Apr;39(4):2121-2127

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

Background: The classification of intrahepatic cholangiocarcinomas (ICCs) has been reported in several studies, however, it remains controversial.

Materials And Methods: Between January 2003 and December 2015, 94 patients underwent hepatectomy for ICC. The ICCs of 63 of these patients were classified as predominantly small bile duct type or bile ductular type ICC and were included in this analysis. Read More

Am J Cancer Res 2019 1;9(3):546-561. Epub 2019 Mar 1.

Department of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University Nanjing 210008, Jiangsu, China.

Sphingosine kinase 2 (SPHK2) is a key factor within sphingolipid metabolism, responsible for the conversion of pro-apoptotic sphingosine to the pro-survival sphingosine-1-phosphate. We have previously shown that ABC294640, a first-in-class SPHK2 inhibitor, inhibits growth of cholangiocarcinoma cells. In a Phase I study of ABC294640 in tumors, the best response was achieved in a cholangiocarcinoma patient. Read More

Am Surg 2019 Mar;85(3):e148-e150

Orphanet J Rare Dis 2019 Apr 3;14(1):77. Epub 2019 Apr 3.

Norwegian Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway.

Background: Porphyria cutanea tarda (PCT) is a skin disorder originating from a deficit of the liver enzyme uroporphyrinogen decarboxylase. PCT may be a risk factor for hepatocellular carcinoma (HCC) and other cancers, but the evidence is unclear. We aimed to investigate cancer and premature mortality risk in persons with PCT. Read More

BJR Case Rep 2018 Dec 21;4(4):20180024. Epub 2018 May 21.

Department of Radiology, Tokyo Medical University Hospital, Tokyo, Japan.

Portal vein thrombosis (PVT) after hepatobiliary surgery is rare but can cause lethal and severe complications. If early diagnosis and recanalization can be achieved, the PVT is expected to be eliminated. A 70-year-old male was diagnosed as having hepatocellular carcinoma occupying the right lobe of the liver. Read More

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):288-292

Ultrasonography Room, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.

To investigate the effects of preoperative percutaneous transhepatic biliary drainage on surgical treatment of type Ⅲ and Ⅳ hilar cholangiocarcinoma. Clinical data of 72 patients with hilar cholangiocarcinoma of the Bismuth-Corlette type Ⅲ and Ⅳ treated at Department of General Surgery,First Affiliated Hospital of Bengbu Medical College from January 2010 to December 2017 were analyzed retrospectively.Patients were divided into two groups based on whether PTBD was performed:a drained group and an undrained group. Read More

Zhonghua Wai Ke Za Zhi 2019 Apr;57(4):247-252

Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

Intrahepatic cholangiocarcinoma(ICC) is the second common primary liver cancer originated from epithelium of the sub-branches of intrahepatic bile ducts with extremely poor prognosis and lack of effective treatment.The prognosis of ICC is mostly affected by the origin,the type and the size of the tumor as well as the intrahepatic metastasis(satellite lesion) and lymph node metastasis etc.Surgical resection remains the first choice of treatment to patients with ICC. Read More

Eur J Radiol 2019 Apr 19;113:182-187. Epub 2019 Feb 19.

Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

We noted the limitations of applying conventional macroscopic patterns to classify the imaging features of cholangiocarcinoma (CCA). Therefore, we hereby propose a dichotomous imaging classification of "parenchymal" and "ductal" types, based on recent developments in the histopathologic concepts of CCA. This new imaging classification of CCA is simple and easy to apply, and can be useful to describe underlying carcinogenesis and correlate clinicopathologic characteristics with imaging patterns of CCA. Read More

World J Gastroenterol 2019 Mar;25(11):1387-1397

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.

Background: Endoscopic papillectomy (EP) for benign ampullary neoplasms could be a less-invasive alternative to pancreatoduodenectomy (PD). There are some problems and limitations with EP. The post-EP resection margins of ampullary tumors are often positive or uncertain because of the burning effect of EP. Read More

Hepatol Res 2019 Mar 25. Epub 2019 Mar 25.

Internal Medicine, Fukui-ken Saiseikai Hospital, 7-1, Funabashi, Wadanaka-cho, Fukui, 918-8503, Japan.

Aim: To retrospectively evaluate the outcomes of conventional transarterial chemoembolization (cTACE) for hepatocellular carcinoma (HCC) ≥10 cm.

Methods: Twenty-five patients with naïve HCCs ≥10 cm (mean maximum tumor diameter, 130 ± 27.6 mm; single [n = 12], 2-9 [n = 6], and ≥10 [n = 7]) without extrahepatic spread treated with cTACE were eligible. Read More

Ann Surg Oncol 2019 Mar 18. Epub 2019 Mar 18.

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: In patients with liver lesions with ductal extension, the corresponding Glissonean pedicle should be divided at its origin to achieve a negative ductal margin; however, during laparoscopic hepatectomy, it is difficult to precisely transect the liver and divide the Glissonean pedicle as planned.

Methods: We present a video of a laparoscopic left lateral sectionectomy using the extrahepatic Glissonean approach for a lesion with ductal extension.

Results: A 76-year-old woman presented with a cystic neoplasm in the liver segment 3 bile duct (B3). Read More

Adv Cancer Res 2019 6;142:107-143. Epub 2019 Mar 6.

3R Biosystems, Long Beach, CA, United States.

Recent clinical studies document the power of immunotherapy in treating subsets of patients with advanced cancers. In this context and with multiple cancer immunotherapeutics already evaluated in the clinic and a large number in various stages of clinical trials, it is imperative to comprehensively examine genomics data to better comprehend the role of immunity in different cancers in predicting response to therapy and in directing appropriate therapies. The approach we chose is to scrutinize the pathways and epigenetic factors predicted to drive immune infiltration in different cancer types using publicly available TCGA transcriptional and methylation datasets, along with accompanying clinico-pathological data. Read More

Diagn Cytopathol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Wonju Severance Christian Hospital, Yonsei University, Wonju, South Korea.

The biological behavior of neuroendocrine tumors (NETs) is heterogeneous and differs from that of cholangiocarcinoma, which is the most common malignant tumor of the biliary tree. However, the preoperative diagnosis of NET in the biliary tree is extremely difficult and to our knowledge, diagnosis by brush cytology has not previously been reported. Herein, we first reported a case of biliary NET preoperatively diagnosed by brush cytology in a 33-year-old female patient. Read More

Liver Int 2019 Mar 18. Epub 2019 Mar 18.

Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome "Foro Italico", Rome, Italy.

Cholangiocarcinoma constitutes a heterogeneous group of malignancies that can emerge at any point of the biliary tree. Cholangiocarcinoma is classified into intrahepatic, perihilar and distal based on its anatomical location. Histologically, conventional perihilar/distal cholangiocarcinomas are mucin-producing adenocarcinomas or papillary tumors; intrahepatic cholangiocarcinomas are more heterogeneous and can be sub-classified according to the level or size of the displayed bile duct. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14729

Department of Liver Surgery & Liver Transplantation Center, West China Hospital of Sichuan University, Chendu, Sichuan.

Rationale: Available literature states that the common reasons for non-traumatic spontaneous liver rupture are hepatocellular carcinoma, macronodular cirrhosis, hemangioma, and other tumors; gallbladder perforation is not cited as a cause.

Patient Concerns: The patient presented with sudden-onset right upper quadrant pain with tarry stool for 3 days after eating with dysphoria and increasing thirst; gradually, hemorrhagic shock developed. He had no history of trauma, no background of chronic hepatitis, and no cirrhosis. Read More

Presse Med 2019 Mar 14;48(3 Pt 2):e125-e145. Epub 2019 Mar 14.

Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy; "Vita-Salute" University, San Raffaele Scientific Institute, Milan, Italy. Electronic address:

The correct diagnosis of a patient presenting with a solid pancreatic mass requires a careful diagnostic work-up, since many differential diagnoses are possible that completely alter the following treatments. In our chapter, we have discussed the clinical approach to the problem in a sort of diagnostic flow-chart. Firstly, we analysed the different potential presentations of a solid pancreatic mass, which can be both asymptomatic or symptomatic, and the differential diagnosis based on the symptoms of presentation. Read More

Rev Environ Health 2018 Dec 20. Epub 2018 Dec 20.

Graduate Institute of Bioresources, National Pingtung University of Science and Technology, Pingtung 912, Taiwan, Phone: +886-8-7703202.

Indoor air quality (IAQ) standards and guidelines for volatile organic compounds (VOCs) have been stipulated by various national and international agencies. The main purpose of this paper is to establish an overview of indoor VOCs regarding their impacts on human health. Herein, 13 VOCs were designated as indoor air pollutants (IAPs) in the IAQ standards and guidelines. Read More

J Gastroenterol Hepatol 2019 Mar 12. Epub 2019 Mar 12.

Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University School of Medicine, Korea.

Background And Aims: Catheter-based endobiliary radiofrequency ablation (RFA) is an endoscopic local treatment for patients with malignant biliary stricture (MBS). However, excessive heating of the bile duct by the current RFA system can induce serious complications. Recently, a new RFA system with automatic temperature control was developed. Read More

Rev Environ Health 2019 Mar;34(1):81-89

Graduate Institute of Bioresources, National Pingtung University of Science and Technology, Pingtung 912, Taiwan, Phone: +886-8-7703202.

Indoor air quality (IAQ) standards and guidelines for volatile organic compounds (VOCs) have been stipulated by various national and international agencies. The main purpose of this paper is to establish an overview of indoor VOCs regarding their impacts on human health. Herein, 13 VOCs were designated as indoor air pollutants (IAPs) in the IAQ standards and guidelines. Read More

Genome Res 2019 04 7;29(4):521-531. Epub 2019 Mar 7.

Molecular Mechanisms and Biomarkers Group, International Agency for Research on Cancer, Lyon 69008, France.

Humans are frequently exposed to acrylamide, a probable human carcinogen found in commonplace sources such as most heated starchy foods or tobacco smoke. Prior evidence has shown that acrylamide causes cancer in rodents, yet epidemiological studies conducted to date are limited and, thus far, have yielded inconclusive data on association of human cancers with acrylamide exposure. In this study, we experimentally identify a novel and unique mutational signature imprinted by acrylamide through the effects of its reactive metabolite glycidamide. Read More

Surg Clin North Am 2019 Apr;99(2):387-401

General Surgery, University of Alabama at Birmingham, 1808 7th Avenue South D202 Boshell Building Birmingham, Alabama 35233, USA; Division of Transplantation, University of Alabama at Birmingham, 701 19th Street South 722 Lyons Harrison Birmingham, Alabama 35233. Electronic address:

Orthotopic liver transplantation (OLT) has many roles in biliary disease. OLT provides excellent results for patients with unresectable hilar cholangiocarcinoma. OLT prolongs survival in primary biliary cirrhosis not responsive to therapy and improves quality of life. Read More

Surg Clin North Am 2019 Apr 10;99(2):357-367. Epub 2019 Feb 10.

Department of Surgery, University of Alabama at Birmingham, 1808 7th Avenue South, BDB 607 Birmingham, AL 35233-3411, USA. Electronic address:

Compared with other periampullary tumors, cancers of the ampulla of Vater are rare. These tumors tend to present earlier than their pancreatic and distal bile duct brethren. In addition to the hypothesis that they are also less biologically aggressive, ampullary cancers tend to have better survival than other types of periampullary cancers. Read More

Surg Clin North Am 2019 Apr 10;99(2):315-335. Epub 2019 Feb 10.

Division of Transplant Surgery, Massachusetts General Hospital, 55 Fruit Street, White 511, Boston, MA 02114, USA.

Cholangiocarcinoma is a rare malignancy and accounts for 2% of all malignancies. Incidence is on the increase in the Western world. Cholangiocarcinoma arises from the malignant growth of the epithelial lining of the bile ducts and can be found all along the biliary tree. Read More

Surg Clin North Am 2019 Apr 10;99(2):301-314. Epub 2019 Feb 10.

Section of General, Thoracic and Vascular Surgery, Virginia Mason Medical Center, 1100 Ninth Avenue, Seattle, WA 98101, USA. Electronic address:

Although the most common presentation of biliary disorder in North America is secondary to gallstone disease, an awareness of benign biliary cystic neoplasms is important because of the risk of malignant transformation. The incidence of premalignant cystic neoplasms of the bile duct is not well characterized and they often are detected incidentally for suspicion of other abdominal disorders. This article describes the 4 most common premalignant biliary cystic neoplasms: biliary mucinous cystic neoplasms, intraductal papillary mucinous neoplasms of the bile duct, intraductal tubular papillary neoplasms of the bile duct, and choledochal cysts. Read More

Sci Rep 2019 Mar 6;9(1):3649. Epub 2019 Mar 6.

Institute of Oncology Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.

The first clinical studies on the use of electrochemotherapy to treat liver tumours that were not amenable to surgery or thermal ablation techniques have recently been published. However, there is still a lack of data on the effects of electrochemotherapy on normal liver tissue. Therefore, we designed a translational animal model study to test whether electrochemotherapy with bleomycin causes clinically significant damage to normal liver tissue, with emphasis on large blood vessels and bile ducts. Read More

J Cancer Res Clin Oncol 2019 Apr 1;145(4):967-999. Epub 2019 Mar 1.

Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Objective: The abnormal expression of the key enzymes in glycolytic pathways, including glucose transporter-1, glucose transporter-3, hexokinase-II, lactate dehydrogenase 5, pyruvate kinase M2, glucose-6-phosphate dehydrogenase, transketolase-like protein 1 and pyruvate dehydrogenase kinase-1 was reported to be associated with poor prognosis of various cancers. However, the association remains controversial. The objective of this study was to investigate the prognostic significance of glycolysis-related proteins. Read More

Gene 2019 May 27;698:50-60. Epub 2019 Feb 27.

Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, China; Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Jiangsu Province, China; NHC Key Laboratory of Living Donor Liver Transplantation (Nanjing Medical University), Nanjing, Jiangsu Province, China. Electronic address:

Aim: We analysed multiple microarray datasets in the Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) DataSets for messenger RNAs (mRNAs) whose expression is apparently increased in human cholangiocarcinoma (CCA) samples, compared with that in the adjacent normal biliary epithelial tissue. The results revealed that the expression of tripartite motif-containing 59 (TRIM59) was significantly increased in the CCA tissue samples. TRIM59 is a member of the tripartite motif (TRIM) protein family, which contains a highly conserved N-terminal-an interesting new gene (RING) domain regulating transcriptional factors and tumorigenesis. Read More

Radiologe 2019 Apr;59(4):315-327

Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Clinical/methodical Issue: Bile duct diseases can be found in all age groups and show an increased prevalence in northern Europe. Pathologies range from benign diseases to malignant tumors with very poor survival.

Standard Radiological Methods: Magnetic resonance imaging (MRI) and computed tomography (CT) are the radiological methods of choice for a detailed evaluation of the bile duct system in addition to sonography. Read More

Am Surg 2019 Feb;85(2):e74-e76

Epigenet Insights 2019 19;12:2516865719828348. Epub 2019 Feb 19.

Translational Research, Cancer Institute, AdventHealth, Orlando, FL, USA.

External pancreatic duct stents inserted after resection of pancreatic head tumors provide unique access to pancreatic juice analysis of genetic and metabolic components that may be associated with peri-ampullary tumor progression. For this pilot study, portal venous blood and pancreatic juice samples were collected from 17 patients who underwent pancreaticoduodenectomy for peri-ampullary tumors. Portal vein circulating tumor cells (CTC) were isolated by high-speed fluorescence-activated cell sorting (FACS) and analyzed by quantitative reverse transcription polymerase chain reaction (RT-PCR) for exon 12 mutant gene expression (). Read More

World J Surg Oncol 2019 Feb 27;17(1):43. Epub 2019 Feb 27.

Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.

Background: The purpose of this study was to explore trends in incidence, incidence-based (IB) mortality, and survival for combined hepatocellular-cholangiocarcinoma (cHCC-CC) utilizing a population-based database to attract people's attention to this disease.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database was utilized to investigate the incidence and IB mortality for cHCC-CC from 2000 to 2014. Trends in age-adjusted incidence and IB mortality were characterized by the Joinpoint Regression program. Read More

Medicine (Baltimore) 2019 Feb;98(8):e14585

Department of General Surgery.

Sarcomatous carcinoma in biliary system, including sarcomatous intrahepatic cholangiocarcinoma (SIC) and sarcomatous choledochal carcinoma (SCC), is extremely rare and malignant.This retrospective study included 5 patients with SIC and 4 patients with SCC. Their basic characteristics, preoperative lab tests, preoperative imaging features, perioperative status, and follow-up information have been collected and analyzed. Read More

Medicine (Baltimore) 2019 Feb;98(8):e14556

Department of Medical Oncology, Acibadem University School of Medicine, Istanbul, Turkey.

Extrahepatic cholangiocarcinoma (ECC) is an aggressive malignancy causing a lot of fatalities and comorbidities. Endoscopic biliary stenting (EBS) is mostly needed for ECC. In this study, we aimed to investigate the prognostic factors for the overall survival (OS) and the factors predicting the patients eligible for chemotherapy after EBS in ECC. Read More

Front Oncol 2019 5;9:38. Epub 2019 Feb 5.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Biliary neuroendocrine neoplasms (NENs) represent <1% of all NENs. The aim of this retrospective study is to present the clinical characteristics, management and prognosis profiles of 28 biliary NEN patients from a large tertiary center, and identify factors related to prognosis. Nine tumors originated from the gallbladder, two from the extrahepatic bile duct and 17 from the ampulla of Vater. Read More

Radiol Bras 2019 Jan-Feb;52(1):41-42

Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Most tumors of the biliary tract are too small to have specific imaging characteristics or for percutaneous puncture to provide sufficient material for diagnosis. Percutaneous transhepatic biliary drainage, in addition to being a well-established technique in the treatment of obstructive jaundice, provides adequate access for sampling obstructive lesions. In cases of biliary lesions, percutaneous transhepatic biopsy of the biliary tract has proven to be a useful diagnostic technique, with a reported accuracy of over 90% at some referral centers. Read More

Dig Endosc 2019 Feb 25. Epub 2019 Feb 25.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background And Aim: An antireflux metal stent (ARMS) for nonresectable distal malignant biliary obstruction may prevent recurrent biliary obstruction (RBO) due to the duodenobiliary reflux and prolong time to RBO (TRBO). The superiority of the ARMS over conventional covered self-expandable metal stents (SEMSs) has not been fully examined.

Methods: We conducted a multicenter randomized controlled trial to examine whether TRBO of an ARMS with a funnel-shaped valve was longer than that of a covered SEMS in SEMS-naïve patients. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Feb;22(2):180-188

Department of General Surgery, Southwest Hospital, Military Medical University, Chongqing 400038, China.

Objective: To explore the feasibility and safety of robotic surgical system for radical gastrectomy after liver transplantation.

Methods: A 65-year-old male patient with gastric cancer after liver transplantation underwent radical distal subtotal gastrectomy using Da Vinci surgical system at the General Surgery Department of Southwest Hospital Affiliated to the Army Military Medical University on October 23,2018. The placement of Trocars was arranged using five-hole method. Read More

World J Gastroenterol 2019 Feb;25(6):659-671

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA 91342, United States.

Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra- and/or extrahepatic biliary ducts. While its features and disease course can be variable, most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly, PSC is associated with a significantly increased risk of malignancy compared to the general population, mainly cholangiocarcinoma, gallbladder carcinoma, hepatocellular carcinoma, and colorectal cancer, with nearly 50% of deaths in patients with PSC being due to cancer. Read More

Prague Med Rep 2018;119(4):165-169

Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Ampulla of Vater metastases from renal cell carcinoma are rare. The time between detection of the primary tumour and its metastasis may extend to years. Management should be aggressive, since the prognosis of renal cell carcinoma is unpredictable and curative surgery of metastases may extend patient survival and even lead to definite cure. Read More

Pediatr Surg Int 2019 May 16;35(5):551-557. Epub 2019 Feb 16.

Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Technology for detecting liver tumors and identifying the bile ducts using indocyanine green (ICG) has recently been developed. However, the usefulness and limitations of ICG navigation surgery for hepatoblastoma (HB) have not been fully clarified. We herein report our experiences with surgical navigation using ICG for in HB patients. Read More

World J Gastroenterol 2019 Feb;25(5):608-621

Department of Internal Medicine, Dong-A University College of Medicine, Busan 49201, South Korea.

Background: Intrahepatic sarcomatoid chonalgiocarcinoma (s-CCC) is an extremely rare disease, accounting for less than 1% of hepatobiliary system malignancies, and its pathophysiology is not well known. On the hypothesis that its clinical, serologic, or radiologic diagnosis are not fully understood and its prognosis is poor, we investigated the distinguishing features of s-CCC compared with those of intrahepatic bile duct adenocarcinoma [cholangiocellular carcinoma (CCC)] in patients from a single center.

Aim: To analyze the clinical, serologic, imaging, and histopathologic characteristics of intrahepatic s-CCC patients diagnosed in a single center. Read More

Int J Surg Case Rep 2019 5;55:187-191. Epub 2019 Feb 5.

Department of General, Visceral, Thoracic and Transplantation Surgery, Department of Pathology, Clinics for Diagnostic and Interventional Radiology, Katharinenhospital Klinikum Stuttgart, Germany.

Background: Intraductal tubular papillary neoplasm (ITPN) displays a very rare subtype of epithelial neoplasms of the pancreas. ITPN is characterized by intraductal tubulopapillary growth and cellular dysplasia. In contrast to intraductal papillary neoplasm (IPMN) no overt epithelial mucin production is observed. Read More

Pathol Int 2019 Feb 6;69(2):86-93. Epub 2019 Feb 6.

Department of Pathology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, Japan, 329-0498.

Bile duct cancer is known to contain numerous fibroblasts, and reported to recruit cancer- associated fibroblasts by secreting platelet-derived growth factor-D (PDGF-D) which needs serine proteases, such as matriptase, to behave as a ligand. However, their expression pattern, and prognostic value have not been clarified. In this study, we investigated the clinicopathological significance of PDGF-D and matriptase expression in patients with extrahepatic bile duct cancer. Read More

Eur J Radiol Open 2019 22;6:62-67. Epub 2019 Jan 22.

Division of Surgery, Department of Clinical Sciences, Karolinska Inst itutet at Danderyd Hospital, 182 88 Stockholm, Sweden.

Introduction: Thermal ablation of liver tumours is an established technique used in selected patients with relatively small tumours that can be ablated with margin. Thermal ablation methods are not advisable near larger bile ducts that are sensitive to thermal injury causing strictures and severe morbidity. Irreversible electroporation (IRE) has the possibility to treat these tumours without harming the bile tree. Read More